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Esteban G. Burchard, MD, MPH

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentBioengineering
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-514-9677
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyM.P.H. Epidemiology2006Public Health
    University of California, San FranciscoPulmonary and Critical Care Medicine2001Medicine
    Brigham and Women's HospitalInternal Medicine Residency1998Medicine
    Harvard University School of Public HealthCertificate, Clinical Effectiveness1997School of Public Health
    Stanford University School of MedicineM.D.1995Medicine
    San Francisco State UniversityB.S. Cellular and Molecular Biology1990Biology
    Collapse Awards and Honors
    2015Precision Medicine Initiative, Advisory Committee to the Director
    2015National Academy of Sciences, Engineering and Medicine, Committee on Incorporating 21st Century Scie
    2014UCSF Medal
    2013Harry Wm. and Diana V. Hind Distinguished Professorship in Pharmaceutical Sciences II
    2013Guest Speaker, Smithsonian Institution National Museum of Natural History (NMNH), Washington D.C.
    2012American Museum of Natural History (AMNH) Documentary featuring our research. New York City
    2011Athletic Hall of Fame, San Francisco State University
    2010Guest Speaker, NPR’s Science Friday, hosted by Ira Flatow
    2009American Society of Clinical Investigation (ASCI), inducted member
    2009Guest Speaker, Tavis Smiley Show
    2008NIH Study Section Member, Genetics of Health and Disease (GHD)
    2005  - 2010RWJ Amos Medical Faculty Development Award
    San Francisco State University1988  - 1989National Collegiate Athletic Association (NCAA) Div. II Academic All-American, Wrestling
    1987California State Espoir Freestyle Wrestling Finalist, 2nd place finish

    Collapse Overview 
    Collapse Overview
    Asthma is the most common chronic disease among children. In the U.S., childhood asthma prevalence is highest among Puerto Ricans (18.4%), followed by Blacks (14.6%), Whites (8.2%) and Mexicans (4.8%). These disparities extend to asthma mortality, which is four-fold higher in Puerto Ricans and African Americans compared to Mexican Americans. There are marked differences in drug response to asthma therapies between racial and ethnic groups, which contribute to health disparities in asthma morbidity and mortality. Albuterol, a short-acting ß2-agonist, is the most commonly prescribed asthma medication in the world. We and others have demonstrated that Puerto Rican and African American children with asthma were significantly less responsive to albuterol than European American children. In addition, long-acting ß2-agonist (LABA) usage has been associated with increased mortality among African American subjects. These findings suggest that poor response to asthma therapies contributes to health disparities in asthma morbidity and mortality. Racial/ethnic differences in drug response are partially explained by genetic differences. We study the interplay between genes and the environment to determine the root causes of asthma health disparities in children and adolescents to identify and develop targeted interventions to improve asthma outcomes.

    I work in collaboration with a multi-disciplinary team of investigators from several Universities, which includes scientists with expertise in epidemiology, biostatistics, medicine, molecular and cell biology and genomics. Using tools from these disciplines, we perform comprehensive research (genetic, social and environmental) designed to untangle why populations differ in health and disease. We have leveraged the rich ancestry of racially mixed (admixed) populations to untangle complex gene-environment interactions for health and disease. We have developed specific expertise in population-based genetic studies in admixed populations. Most importantly, we are working to ensure that modern advances in research will benefit all populations.


    Collapse Research 
    Collapse Research Activities and Funding
    Center for Multi- and Trans-ethnic Mapping of Mendelian and Complex Diseases
    NIH U01HG009080May 2, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Genes, air pollution, and asthma severity in minority children
    NIH R01MD010443Apr 22, 2016 - Dec 31, 2020
    Role: Principal Investigator
    Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse Children
    NIH R21ES024844Dec 1, 2014 - Nov 30, 2017
    Role: Principal Investigator
    UCSF Career Development Program in Omics of Lung Diseases
    NIH/NHLBI K12HL119997Sep 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Pharmacogenomics of Bronchodilator Response in Minority Children with Asthma
    NIH R01HL117004Aug 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Addressing disparities in chronic disease with a teen and young adult focus
    NIH/NIMHD P60MD006902Aug 27, 2012 - Feb 28, 2017
    Role: Co-Investigator
    Gene-environments and Admixture in Latino Asthmatics (GALA 2)
    NIH R01ES015794Sep 1, 2008 - May 31, 2014
    Role: Principal Investigator
    IL-13 and IL-17 dynamics in the asthmatic airway
    NIH/NIAID U19AI077439Apr 1, 2008 - Mar 31, 2018
    Role: Co-Investigator
    Whole Genome Analyses for Asthma in Latino Populations
    NIH R01HL088133Mar 1, 2008 - Feb 28, 2014
    Role: Principal Investigator
    Case-control Association Studies and Genetic Confounding
    NIH R01HL078885Aug 15, 2005 - Jul 31, 2010
    Role: Principal Investigator
    Genetics of Asthma In Latino Americans
    NIH K23HL004464Jul 5, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Pharmacogenomics of Membrane Transporters
    NIH U19GM061390Apr 1, 2000 - Jun 30, 2015
    Role: Co-Investigator
    Clinical Pharmacology, Drug Action and Pharmacogenetics
    NIH/NIGMS T32GM007546Jul 1, 1977 - Jun 30, 2020
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Park DS, Eskin I, Kang EY, Gamazon ER, Eng C, Gignoux CR, Galanter JM, Burchard E, Ye CJ, Aschard H, Eskin E, Halperin E, Zaitlen N. An ancestry-based approach for detecting interactions. Genet Epidemiol. 2017 Nov 08. PMID: 29114909.
      View in: PubMed
    2. McGarry ME, Neuhaus JM, Nielson DW, Burchard E, Ly NP. Pulmonary function disparities exist and persist in Hispanic patients with cystic fibrosis: A longitudinal analysis. Pediatr Pulmonol. 2017 Oct 30. PMID: 29082671.
      View in: PubMed
    3. Hiatt RA, Handley MA, Ling PM, Burchard E, Thakur N, Bibbins-Domingo K. Origins of Cancer Disparities in Young Adults: Logic Models to Guide Research. Am J Prev Med. 2017 Sep; 53(3S1):S95-S102. PMID: 28818252.
      View in: PubMed
    4. Yue JK, Robinson CK, Burke JF, Winkler EA, Deng H, Cnossen MC, Lingsma HF, Ferguson AR, McAllister TW, Rosand J, Burchard E, Sorani MD, Sharma S, Nielson JL, Satris GG, Talbott JF, Tarapore PE, Korley FK, Wang KKW, Yuh EL, Mukherjee P, Diaz-Arrastia R, Valadka AB, Okonkwo DO, Manley GT. Apolipoprotein E epsilon 4 (APOE-e4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury. Brain Behav. 2017 Sep; 7(9):e00791. PMID: 28948085.
      View in: PubMed
    5. Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard E, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, Punturieri A, Freemer MM, Wise RA. American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report. Am J Respir Crit Care Med. 2017 Aug 01; 196(3):375-381. PMID: 28636425.
      View in: PubMed
    6. Sherenian MG, Cho SH, Levin A, Min JY, Oh SS, Hu D, Galanter J, Sen S, Huntsman S, Eng C, Rodriguez-Santana JR, Serebrisky D, Avila PC, Kalhan R, Smith LJ, Borrell LN, Seibold MA, Keoki Williams L, Burchard E, Kumar R. PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort. Clin Exp Allergy. 2017 Sep; 47(9):1150-1158. PMID: 28543872.
      View in: PubMed
    7. Farzan N, Vijverberg SJ, Andiappan AK, Arianto L, Berce V, Blanca-López N, Bisgaard H, Bønnelykke K, Burchard E, Campo P, Canino G, Carleton B, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Daley D, Den Dekker HT, Dijk FN, Duijts L, Flores C, Forno E, Hawcutt DB, Hernandez-Pacheco N, de Jongste JC, Kabesch M, Koppelman GH, Manolopoulos VG, Melén E, Mukhopadhyay S, Nilsson S, Palmer CN, Pino-Yanes M, Pirmohamed M, Potocnik U, Raaijmakers JA, Repnik K, Schieck M, Sio YY, Smyth RL, Szalai C, Tantisira KG, Turner S, van der Schee MP, Verhamme KM, Maitland-van der Zee AH. Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. Pharmacogenomics. 2017 07; 18(10):931-943. PMID: 28639505.
      View in: PubMed
    8. Carlson S, Borrell LN, Eng C, Nguyen M, Thyne S, LeNoir MA, Burke-Harris N, Burchard E, Thakur N. Self-reported racial/ethnic discrimination and bronchodilator response in African American youth with asthma. PLoS One. 2017; 12(6):e0179091. PMID: 28609485.
      View in: PubMed
    9. Yan Q, Brehm J, Pino-Yanes M, Forno E, Lin J, Oh SS, Acosta-Perez E, Laurie CC, Cloutier MM, Raby BA, Stilp AM, Sofer T, Hu D, Huntsman S, Eng CS, Conomos MP, Rastogi D, Rice K, Canino G, Chen W, Barr RG, Burchard E, Celedón JC. A meta-analysis of genome-wide association studies of asthma in Puerto Ricans. Eur Respir J. 2017 May; 49(5). PMID: 28461288.
      View in: PubMed
    10. Hernandez-Pacheco N, Flores C, Alonso S, Eng C, Mak AC, Hunstman S, Hu D, White MJ, Oh SS, Meade K, Farber HJ, Avila PC, Serebrisky D, Thyne SM, Brigino-Buenaventura E, Rodriguez-Cintron W, Sen S, Kumar R, Lenoir M, Rodriguez-Santana JR, Burchard E, Pino-Yanes M. Identification of a novel locus associated with skin colour in African-admixed populations. Sci Rep. 2017 Mar 16; 7:44548. PMID: 28300201.
      View in: PubMed
    11. Rahmani E, Zaitlen N, Baran Y, Eng C, Hu D, Galanter J, Oh S, Burchard E, Eskin E, Zou J, Halperin E. Correcting for cell-type heterogeneity in DNA methylation: a comprehensive evaluation. Nat Methods. 2017 Feb 28; 14(3):218-219. PMID: 28245214.
      View in: PubMed
    12. Marques CR, Costa GN, da Silva TM, Oliveira P, Cruz AA, Alcantara-Neves NM, Fiaccone RL, Horta BL, Hartwig FP, Burchard E, Pino-Yanes M, Rodrigues LC, Lima-Costa MF, Pereira AC, Gouveia MH, Sant Anna HP, Tarazona-Santos E, Lima Barreto M, Figueiredo CA. Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children. Eur J Hum Genet. 2017 Apr; 25(4):439-445. PMID: 28120837.
      View in: PubMed
    13. Wesolowska-Andersen A, Everman JL, Davidson R, Rios C, Herrin R, Eng C, Janssen WJ, Liu AH, Oh SS, Kumar R, Fingerlin TE, Rodriguez-Santana J, Burchard E, Seibold MA. Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome. Genome Biol. 2017 Jan 19; 18(1):12. PMID: 28103897.
      View in: PubMed
    14. Chen W, Wang T, Pino-Yanes M, Forno E, Liang L, Yan Q, Hu D, Weeks DE, Baccarelli A, Acosta-Perez E, Eng C, Han YY, Boutaoui N, Laprise C, Davies GA, Hopkin JM, Moffatt MF, Cookson WO, Canino G, Burchard E, Celedón JC. An epigenome-wide association study of total serum IgE in Hispanic children. J Allergy Clin Immunol. 2017 Aug; 140(2):571-577. PMID: 28069425.
      View in: PubMed
    15. Galanter JM, Gignoux CR, Oh SS, Torgerson D, Pino-Yanes M, Thakur N, Eng C, Hu D, Huntsman S, Farber HJ, Avila PC, Brigino-Buenaventura E, LeNoir MA, Meade K, Serebrisky D, Rodríguez-Cintrón W, Kumar R, Rodríguez-Santana JR, Seibold MA, Borrell LN, Burchard E, Zaitlen N. Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures. Elife. 2017 01 03; 6. PMID: 28044981.
      View in: PubMed
    16. Rahmani E, Shenhav L, Schweiger R, Yousefi P, Huen K, Eskenazi B, Eng C, Huntsman S, Hu D, Galanter J, Oh SS, Waldenberger M, Strauch K, Grallert H, Meitinger T, Gieger C, Holland N, Burchard E, Zaitlen N, Halperin E. Genome-wide methylation data mirror ancestry information. Epigenetics Chromatin. 2017; 10:1. PMID: 28149326.
      View in: PubMed
    17. Oh S, Du R, Zeiger AM, Mcgarry ME, Hu D, Thakur N, Pino-Yanes M, Galanter JM, Farber HJ, Eng C, Nishimura KK, Huntsman S, Meade K, Avila P, Serebrisky D, Bibbins-Domingo K, Lenoir MA, Ford JG, Brigino-Buenaventura E, Rodriguez-Cintron W, Thyne SM, Sen S, Rodriguez-Santana JR, Williams K, Kumar R, Burchard E. Breastfeeding associated with higher lung function in African American youths with asthma. J Asthma. 2016 Dec 08; 1-10. PMID: 27929698.
      View in: PubMed
    18. Thakur N, Barcelo NE, Borrell LN, Singh S, Eng C, Davis A, Meade K, LeNoir MA, Avila PC, Farber HJ, Serebrisky D, Brigino-Buenaventura E, Rodriguez-Cintron W, Thyne S, Rodriguez-Santana JR, Sen S, Bibbins-Domingo K, Burchard E. Perceived Discrimination Associated With Asthma and Related Outcomes in Minority Youth: The GALA II and SAGE II Studies. Chest. 2017 Apr; 151(4):804-812. PMID: 27916618.
      View in: PubMed
    19. Rid A, Johansson MA, Leung G, Valantine H, Burchard E, Oh SS, Zimmerman C. Towards Equity in Health: Researchers Take Stock. PLoS Med. 2016 Nov; 13(11):e1002186. PMID: 27898673.
      View in: PubMed
    20. Zaitlen N, Huntsman S, Hu D, Spear M, Eng C, Oh SS, White MJ, Mak A, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Bibbins-Domingo K, Burchard E, Halperin E. The Effects of Migration and Assortative Mating on Admixture Linkage Disequilibrium. Genetics. 2017 Jan; 205(1):375-383. PMID: 27879348.
      View in: PubMed
    21. Yue JK, Winkler EA, Rick JW, Burke JF, McAllister TW, Oh SS, Burchard E, Hu D, Rosand J, Temkin NR, Korley FK, Sorani MD, Ferguson AR, Lingsma HF, Sharma S, Robinson CK, Yuh EL, Tarapore PE, Wang KK, Puccio AM, Mukherjee P, Diaz-Arrastia R, Gordon WA, Valadka AB, Okonkwo DO, Manley GT. DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury. Neurogenetics. 2017 Jan; 18(1):29-38. PMID: 27826691.
      View in: PubMed
    22. Winkler EA, Yue JK, Ferguson AR, Temkin NR, Stein MB, Barber J, Yuh EL, Sharma S, Satris GG, McAllister TW, Rosand J, Sorani MD, Lingsma HF, Tarapore PE, Burchard E, Hu D, Eng C, Wang KK, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley GT. COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury. J Clin Neurosci. 2017 Jan; 35:109-116. PMID: 27769642.
      View in: PubMed
    23. Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Oliveira R, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard E, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J, Barnes KC. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nat Commun. 2016 Oct 11; 7:12522. PMID: 27725671.
      View in: PubMed
    24. Cho SH, Min JY, Kim DY, Oh SS, Torgerson DR, Pino-Yanes M, Hu D, Sen S, Huntsman S, Eng C, Farber HJ, Rodriguez-Cintron W, Rodriguez-Santana JR, Serebrisky D, Thyne SM, Borrell LN, Williams LK, DuPont W, Seibold MA, Burchard E, Avila PC, Kumar R. Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function. PLoS One. 2016; 11(8):e0157848. PMID: 27556405; PMCID: PMC4996454.
    25. Cajigal S, Wells KE, Peterson EL, Ahmedani BK, Yang JJ, Kumar R, Burchard E, Williams LK. Predictive Properties of the Asthma Control Test and Its Component Questions for Severe Asthma Exacerbations. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):121-127.e2. PMID: 27544712.
      View in: PubMed
    26. Abid Z, Oh SS, Hu D, Sen S, Huntsman S, Eng C, Farber HJ, Rodriguez-Cintron W, Rodriguez-Santana JR, Serebrisky D, Avila PC, Thyne SM, Kim KA, Borrell LN, Williams LK, Seibold MA, Burchard E, Kumar R. Maternal age and asthma in Latino populations. Clin Exp Allergy. 2016 Nov; 46(11):1398-1406. PMID: 27238356.
      View in: PubMed
    27. Hernandez-Pacheco N, Flores C, Oh SS, Burchard E, Pino-Yanes M. What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression. Curr Allergy Asthma Rep. 2016 Jul; 16(8):53. PMID: 27393700.
      View in: PubMed
    28. Roberts JD, Hu D, Heckbert SR, Alonso A, Dewland TA, Vittinghoff E, Liu Y, Psaty BM, Olgin JE, Magnani JW, Huntsman S, Burchard E, Arking DE, Bibbins-Domingo K, Harris TB, Perez MV, Ziv E, Marcus GM. Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals. JAMA Cardiol. 2016 Jul 01; 1(4):442-50. PMID: 27438321.
      View in: PubMed
    29. Nishimura KK, Iwanaga K, Oh SS, Pino-Yanes M, Eng C, Keswani A, Roth LA, Nguyen EA, Thyne SM, Farber HJ, Serebrisky D, Meade K, LeNoir MA, Rodriguez-Cintron W, Borrell LN, Bibbins-Domingo K, Lurmann F, Sen S, Rodriguez-Santana JR, Brigino-Buenaventura E, Avila PC, Balmes JR, Kumar R, Burchard E, et al. Early-life ozone exposure associated with asthma without sensitization in Latino children. J Allergy Clin Immunol. 2016 Dec; 138(6):1703-1706.e1. PMID: 27423496.
      View in: PubMed
    30. Neophytou AM, White MJ, Oh SS, Thakur N, Galanter JM, Nishimura KK, Pino-Yanes M, Torgerson DG, Gignoux CR, Eng C, Nguyen EA, Hu D, Mak AC, Kumar R, Seibold MA, Davis A, Farber HJ, Meade K, Avila PC, Serebrisky D, Lenoir MA, Brigino-Buenaventura E, Rodriguez-Cintron W, Bibbins-Domingo K, Thyne SM, Williams LK, Sen S, Gilliland FD, Gauderman WJ, Rodriguez-Santana JR, Lurmann F, Balmes JR, Eisen EA, Burchard E. Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies. Am J Respir Crit Care Med. 2016 Jun 01; 193(11):1271-80. PMID: 26734713; PMCID: PMC4910900 [Available on 06/01/17].
    31. White MJ, Risse-Adams O, Goddard P, Contreras MG, Adams J, Hu D, Eng C, Oh SS, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Bibbins-Domingo K, Pino-Yanes M, Burchard E. Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study. Immunogenetics. 2016 Jul; 68(6-7):391-400. PMID: 27142222; PMCID: PMC4927336 [Available on 07/01/17].
    32. Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard E, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science. 2016 Apr 01; 352(6281):99-103. PMID: 27034374; PMCID: PMC4935984.
    33. Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ, Küpers LK, Oh SS, Hoyo C, Gruzieva O, Söderhäll C, Salas LA, Baïz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA, Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D, Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U, Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J, Gonzalez JR, Peters MJ, Håberg SE, Xu Z, van Meurs JB, Gaunt TR, Kerkhof M, Corpeleijn E, Feinberg AP, Eng C, Baccarelli AA, Benjamin Neelon SE, Bradman A, Merid SK, Bergström A, Herceg Z, Hernandez-Vargas H, Brunekreef B, Pinart M, Heude B, Ewart S, Yao J, Lemonnier N, Franco OH, Wu MC, Hofman A, McArdle W, Van der Vlies P, Falahi F, Gillman MW, Barcellos LF, Kumar A, Wickman M, Guerra S, Charles MA, Holloway J, Auffray C, Tiemeier HW, Smith GD, Postma D, Hivert MF, Eskenazi B, Vrijheid M, Arshad H, Antó JM, Dehghan A, Karmaus W, Annesi-Maesano I, Sunyer J, Ghantous A, Pershagen G, Holland N, Murphy SK, DeMeo DL, Burchard E, Ladd-Acosta C, Snieder H, Nystad W, Koppelman GH, Relton CL, Jaddoe VW, Wilcox A, Melén E, London SJ. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 07; 98(4):680-96. PMID: 27040690; PMCID: PMC4833289 [Available on 10/07/16].
    34. Rahmani E, Zaitlen N, Baran Y, Eng C, Hu D, Galanter J, Oh S, Burchard E, Eskin E, Zou J, Halperin E. Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies. Nat Methods. 2016 May; 13(5):443-5. PMID: 27018579.
      View in: PubMed
    35. Wells KE, Cajigal S, Peterson EL, Ahmedani BK, Kumar R, Lanfear DE, Burchard E, Williams LK. Assessing differences in inhaled corticosteroid response by self-reported race-ethnicity and genetic ancestry among asthmatic subjects. J Allergy Clin Immunol. 2016 May; 137(5):1364-1369.e2. PMID: 27016472.
      View in: PubMed
    36. Dewland TA, Bibbins-Domingo K, Lin F, Vittinghoff E, Foster E, Ogunyankin KO, Lima JA, Jacobs DR, Hu D, Burchard E, Marcus GM. Racial Differences in Left Atrial Size: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) Study. PLoS One. 2016; 11(3):e0151559. PMID: 26985672; PMCID: PMC4795666.
    37. Oh SS, White MJ, Gignoux CR, Burchard E. Making Precision Medicine Socially Precise. Take a Deep Breath. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):348-50. PMID: 26871667; PMCID: PMC4803087 [Available on 02/15/17].
    38. Turner S, Francis B, Vijverberg S, Pino-Yanes M, Maitland-van der Zee AH, Basu K, Bignell L, Mukhopadhyay S, Tavendale R, Palmer C, Hawcutt D, Pirmohamed M, Burchard E, Lipworth B. Childhood asthma exacerbations and the Arg16 ß2-receptor polymorphism: A meta-analysis stratified by treatment. J Allergy Clin Immunol. 2016 Jul; 138(1):107-113.e5. PMID: 26774659; PMCID: PMC4931969 [Available on 07/01/17].
    39. Oh SS, Galanter J, Thakur N, Pino-Yanes M, Barcelo NE, White MJ, de Bruin DM, Greenblatt RM, Bibbins-Domingo K, Wu AH, Borrell LN, Gunter C, Powe NR, Burchard E. Diversity in Clinical and Biomedical Research: A Promise Yet to Be Fulfilled. PLoS Med. 2015 Dec; 12(12):e1001918. PMID: 26671224; PMCID: PMC4679830.
    40. Costa GN, Dudbridge F, Fiaccone RL, da Silva TM, Conceição JS, Strina A, Figueiredo CA, Magalhães WC, Rodrigues MR, Gouveia MH, Kehdy FS, Horimoto AR, Horta B, Burchard E, Pino-Yanes M, Del Rio Navarro B, Romieu I, Hancock DB, London S, Lima-Costa MF, Pereira AC, Tarazona E, Rodrigues LC, Barreto ML. A genome-wide association study of asthma symptoms in Latin American children. BMC Genet. 2015 Dec 03; 16:141. PMID: 26635092; PMCID: PMC4669662.
    41. Padhukasahasram B, Reddy CK, Levin AM, Burchard E, Williams LK. Powerful Tests for Multi-Marker Association Analysis Using Ensemble Learning. PLoS One. 2015; 10(11):e0143489. PMID: 26619286; PMCID: PMC4664402.
    42. Winkler EA, Yue JK, McAllister TW, Temkin NR, Oh SS, Burchard E, Hu D, Ferguson AR, Lingsma HF, Burke JF, Sorani MD, Rosand J, Yuh EL, Barber J, Tarapore PE, Gardner RC, Sharma S, Satris GG, Eng C, Puccio AM, Wang KK, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT. COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury. Neurogenetics. 2016 Jan; 17(1):31-41. PMID: 26576546; PMCID: PMC4988810 [Available on 01/01/17].
    43. Santos C, Phillips C, Fondevila M, Daniel R, van Oorschot RA, Burchard E, Schanfield MS, Souto L, Uacyisrael J, Via M, Carracedo Á, Lareu MV. Pacifiplex: an ancestry-informative SNP panel centred on Australia and the Pacific region. Forensic Sci Int Genet. 2016 Jan; 20:71-80. PMID: 26517174.
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    147. Williams LK, Oliver J, Peterson EL, Bobbitt KR, McCabe MJ, Smolarek D, Havstad SL, Wegienka G, Burchard E, Ownby DR, Johnson CC. Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3+ and Foxp3- CD4+ lymphocyte numbers and total serum IgE levels in early childhood. Ann Allergy Asthma Immunol. 2008 Feb; 100(2):128-36. PMID: 18320914; PMCID: PMC2646830.
    148. Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard E, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther. 2008; 83(2):273-80.
    149. Salari K, Burchard E. Latino populations: a unique opportunity for epidemiological research of asthma. Paediatr Perinat Epidemiol. 2007 Nov; 21 Suppl 3:15-22. PMID: 17935571.
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    150. Naqvi M, Thyne S, Choudhry S, Tsai HJ, Navarro D, Castro RA, Nazario S, Rodriguez-Santana JR, Casal J, Torres A, Chapela R, Watson HG, Meade K, LeNoir M, Avila PC, Rodriguez-Cintron W, Burchard E. Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma. J Asthma. 2007 Oct; 44(8):639-48. PMID: 17943575.
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    151. Paschou P, Ziv E, Burchard E, Choudhry S, Rodriguez-Cintron W, Mahoney MW, Drineas P. PCA-correlated SNPs for structure identification in worldwide human populations. PLoS Genet. 2007 Sep; 3(9):1672-86. PMID: 17892327; PMCID: PMC1988848.
    152. Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard E, Giacomini KM. Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenet Genomics. 2007 Sep; 17(9):773-82. PMID: 17700366.
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    153. Tang H, Choudhry S, Mei R, Morgan M, Rodriguez-Cintron W, Burchard E, Risch NJ. Recent genetic selection in the ancestral admixture of Puerto Ricans. Am J Hum Genet. 2007 Sep; 81(3):626-33. PMID: 17701908; PMCID: PMC1950843.
    154. Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard E, Giacomini KM. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther. 2008 Mar; 83(3):416-21. PMID: 17609685.
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    155. Choudhry S, Seibold MA, Borrell LN, Tang H, Serebrisky D, Chapela R, Rodriguez-Santana JR, Avila PC, Ziv E, Rodriguez-Cintron W, Risch NJ, Burchard E. Dissecting complex diseases in complex populations: asthma in latino americans. Proc Am Thorac Soc. 2007 Jul; 4(3):226-33. PMID: 17607004; PMCID: PMC2647623.
    156. Naqvi M, Choudhry S, Tsai HJ, Thyne S, Navarro D, Nazario S, Rodriguez-Santana JR, Casal J, Torres A, Chapela R, Watson HG, Meade K, Rodriguez-Cintron W, Lenoir M, Avila PC, Burchard E. Association between IgE levels and asthma severity among African American, Mexican, and Puerto Rican patients with asthma. J Allergy Clin Immunol. 2007 Jul; 120(1):137-43. PMID: 17498790.
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    157. Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard E, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest. 2007 May; 117(5):1422-31. PMID: 17476361; PMCID: PMC1857259.
    158. Demeo DL, Sandhaus RA, Barker AF, Brantly ML, Eden E, McElvaney NG, Rennard S, Burchard E, Stocks JM, Stoller JK, Strange C, Turino GM, Campbell EJ, Silverman EK. Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. Thorax. 2007 Sep; 62(9):806-13. PMID: 17389752; PMCID: PMC2117297.
    159. Battle NC, Choudhry S, Tsai HJ, Eng C, Kumar G, Beckman KB, Naqvi M, Meade K, Watson HG, Lenoir M, Burchard E. Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma. Am J Respir Crit Care Med. 2007 May 01; 175(9):881-7. PMID: 17303794; PMCID: PMC1899298.
    160. Peralta CA, Ziv E, Katz R, Reiner A, Burchard E, Fried L, Kwok PY, Psaty B, Shlipak M. African ancestry, socioeconomic status, and kidney function in elderly African Americans: a genetic admixture analysis. J Am Soc Nephrol. 2006 Dec; 17(12):3491-6. PMID: 17082243.
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    161. Ziv E, John EM, Choudhry S, Kho J, Lorizio W, Perez-Stable EJ, Burchard E. Genetic ancestry and risk factors for breast cancer among Latinas in the San Francisco Bay Area. Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1878-85. PMID: 17035394; PMCID: PMC5033763.
    162. Tsai YJ, Choudhry S, Kho J, Beckman K, Tsai HJ, Navarro D, Matallana H, Castro RA, Lilly CM, Nazario S, Rodriguez-Santana JR, Casal J, Torres A, Salas J, Chapela R, Watson HG, Meade K, Avila PC, Rodriguez-Cintron W, LeNoir M, Burchard E. The PTGDR gene is not associated with asthma in 3 ethnically diverse populations. J Allergy Clin Immunol. 2006 Dec; 118(6):1242-8. PMID: 17157653.
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    163. Choudhry S, Burchard E, Borrell LN, Tang H, Gomez I, Naqvi M, Nazario S, Torres A, Casal J, Martinez-Cruzado JC, Ziv E, Avila PC, Rodriguez-Cintron W, Risch NJ. Ancestry-environment interactions and asthma risk among Puerto Ricans. Am J Respir Crit Care Med. 2006 Nov 15; 174(10):1088-93. PMID: 16973984; PMCID: PMC2648109.
    164. Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard E, Packman S, Giacomini KM. Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Mol Pharmacol. 2006 Nov; 70(5):1602-11. PMID: 16931768.
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    165. Slavotinek AM, Moshrefi A, Davis R, Leeth E, Schaeffer GB, Burchard E, Shaw GM, James B, Ptacek L, Pennacchio LA. Array comparative genomic hybridization in patients with congenital diaphragmatic hernia: mapping of four CDH-critical regions and sequencing of candidate genes at 15q26.1-15q26.2. Eur J Hum Genet. 2006 Sep; 14(9):999-1008. PMID: 16736036.
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    166. Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard E, Giacomini KM. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug; 318(2):521-9. PMID: 16702441.
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    167. Tsai HJ, Shaikh N, Kho JY, Battle N, Naqvi M, Navarro D, Matallana H, Lilly CM, Eng CS, Kumar G, Thyne S, Watson HG, Meade K, LeNoir M, Choudhry S, Burchard E. Beta 2-adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics. Hum Genet. 2006 Jun; 119(5):547-57. PMID: 16596417.
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    168. Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard E, Herskowitz I, Kroetz DL, Giacomini KM. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):5-6. PMID: 16507879.
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    169. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard E, Herskowitz I, Kroetz DL, Giacomini KM. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Pharmacol Rev. 2006 Mar; 58(1):3-4. PMID: 16507878.
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    170. Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard E, Giacomini KM. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F905-12. PMID: 16291576.
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    171. Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard D, Shriver MD, Rodriguez-Cintron W, Risch N, Ziv E, Burchard E. Population stratification confounds genetic association studies among Latinos. Hum Genet. 2006 Jan; 118(5):652-64. PMID: 16283388.
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    172. Tsai HJ, Kho JY, Shaikh N, Choudhry S, Naqvi M, Navarro D, Matallana H, Castro R, Lilly CM, Watson HG, Meade K, Lenoir M, Thyne S, Ziv E, Burchard E. Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations. Hum Genet. 2006 Jan; 118(5):626-39. PMID: 16273390; PMCID: PMC3478103.
    173. Tsai HJ, Choudhry S, Naqvi M, Rodriguez-Cintron W, Burchard E, Ziv E. Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populations. Hum Genet. 2005 Dec; 118(3-4):424-33. PMID: 16208514.
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    174. Pawlikowska L, Tran MN, Achrol AS, Ha C, Burchard E, Choudhry S, Zaroff J, Lawton MT, Castro R, McCulloch CE, Marchuk D, Kwok PY, Young WL. Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations. Stroke. 2005 Oct; 36(10):2278-80. PMID: 16179574.
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    175. Salari K, Choudhry S, Tang H, Naqvi M, Lind D, Avila PC, Coyle NE, Ung N, Nazario S, Casal J, Torres-Palacios A, Clark S, Phong A, Gomez I, Matallana H, Pérez-Stable EJ, Shriver MD, Kwok PY, Sheppard D, Rodriguez-Cintron W, Risch NJ, Burchard E, Ziv E. Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol. 2005 Jul; 29(1):76-86. PMID: 15918156.
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    176. Choudhry S, Avila PC, Nazario S, Ung N, Kho J, Rodriguez-Santana JR, Casal J, Tsai HJ, Torres A, Ziv E, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Castro RA, Selman M, Weiss ST, Ford JG, Drazen JM, Rodriguez-Cintron W, Chapela R, Silverman EK, Burchard E. CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma. Am J Respir Crit Care Med. 2005 Jul 15; 172(2):173-82. PMID: 15879416.
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    177. Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard E, Ferrin TE, Huang CC, Leabman MK, Giacomini KM. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005 Apr; 15(4):201-9. PMID: 15864112.
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    178. Reiner AP, Ziv E, Lind DL, Nievergelt CM, Schork NJ, Cummings SR, Phong A, Burchard E, Harris TB, Psaty BM, Kwok PY. Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study. Am J Hum Genet. 2005 Mar; 76(3):463-77. PMID: 15660291; PMCID: PMC1196398.
    179. Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard E, Giacomini KM. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005; 5(3):157-65. PMID: 15738947.
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    180. Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, Lilly C, Matallana H, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Drazen JM, Rodriguez-Cintron W, Silverman EK, Burchard E. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):563-70. PMID: 15557128.
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    181. Burchard E, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004 Feb 01; 169(3):386-92. PMID: 14617512.
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    182. Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, Chapela R, Ford JG, Rodriguez-Cintron W, Silverman EK, Sheppard D, Kwok PY, González Burchard E. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1312-6. PMID: 12958057.
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    183. Ziv E, Burchard E. Human population structure and genetic association studies. Pharmacogenomics. 2003 Jul; 4(4):431-41. PMID: 12831322.
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    184. Burchard E, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003 Mar 20; 348(12):1170-5. PMID: 12646676.
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    185. Risch N, Burchard E, Ziv E, Tang H. Categorization of humans in biomedical research: genes, race and disease. Genome Biol. 2002 Jul 01; 3(7):comment2007. PMID: 12184798; PMCID: PMC139378.
    186. Burchard E, Silverman EK, Rosenwasser LJ, Borish L, Yandava C, Pillari A, Weiss ST, Hasday J, Lilly CM, Ford JG, Drazen JM. Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma. Am J Respir Crit Care Med. 1999 Sep; 160(3):919-22. PMID: 10471619.
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    187. Wu CJ, Kurbegov D, Lattin B, Burchard E, Finkle C, Valantine H, Billingham ME, Starnes VA, Clayberger C. Cytokine gene expression in human cardiac allograft recipients. Transpl Immunol. 1994 Sep; 2(3):199-207. PMID: 8000848.
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    188. Whitehead BF, Stoehr C, Wu CJ, Patterson G, Burchard E, Theodore J, Clayberger C, Starnes VA. Cytokine gene expression in human lung transplant recipients. Transplantation. 1993 Oct; 56(4):956-61. PMID: 7692639.
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