An Cheng • UCSF Profiles

An Cheng, PhD

Title(s)	Postdoctoral Scholar, Ophthalmology
School	School of Medicine
Address	1550 Fourth Street, #445 San Francisco CA 94158
ORCID	0000-0002-7816-203X
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Biography

Education and Training

Tohoku University, Sendai, Japan	Ph.D.	03/2022	Neuropharmacology
China Pharmaceutical University, Nanjing, China	B.S.	06/2016	Pharmaceutical Science

Awards and Honors

Tohoku University	2022		Tohoku University President’s Award
Tohoku University	2021		Tohoku University Professor Fujino Incentive Award
The Uehara Memorial Foundation	2020 -	2021	The Uehara Memorial Foundation Fellowship

Overview

As a Postdoctoral Scholar in the Ophthalmology department at UCSF, my research interests revolve around neurodegeneration and aging. Through my authored research publications, I have contributed to the understanding of fatty acid-binding proteins (FABPs) and their involvement in neurodegenerative diseases such as Parkinson's disease. My work includes exploring novel therapeutic approaches and inhibitors to protect against memory loss and mitochondrial damage induced by neurodegenerative processes. I am honored to have received prestigious awards and fellowships, including the Tohoku University President's Award and The Uehara Memorial Foundation Fellowship. I hold a Ph.D. in Neuropharmacology from Tohoku University, Sendai, Japan, and a B.S. in Pharmaceutical Science from China Pharmaceutical University, Nanjing, China.

Interests

Aging, Neurodegeneration

Websites

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	Personal Homepage

ORNG Applications

Featured Publications

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment. Expert Opin Ther Targets. 2023 Jul-Dec; 27(11):1031-1034. Cheng A, Cai B, Fukunaga K, Sasaki T, Lakkaraju A. PMID: 37902421.

View in: PubMed Mentions: Fields:
The Therapeutics
Translation:Humans
Editorial: Myelin in white mater function and related diseases. Front Mol Neurosci. 2023; 16:1284273. Tian Z, Cheng A. PMID: 37771557; PMCID: PMC10523341.

View in: PubMed Mentions:
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model. Acta Pharmacol Sin. 2024 Jan; 45(1):66-75. Cheng A, Jia W, Finkelstein DI, Stefanova N, Wang H, Sasaki T, Kawahata I, Fukunaga K. PMID: 37605049; PMCID: PMC10770047.

View in: PubMed Mentions: 2 Fields:
Pha Pharmacology
Translation:Animals Cells
Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation. Brain. 2023 08 01; 146(8):3172-3180. Cheng A, Kawahata I, Wang Y, Jia W, Wang H, Sekimori T, Chen Y, Suzuki H, Takeda A, Stefanova N, Finkelstein DI, Ma W, Chen M, Sasaki T, Fukunaga K. PMID: 37082980.

View in: PubMed Mentions: 3 Fields:
Bra Brain Neu Neurology
Translation:Animals Cells
Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor. Int J Mol Sci. 2023 Apr 02; 24(7). Jia W, Kawahata I, Cheng A, Sasaki T, Sasaoka T, Fukunaga K. PMID: 37047614; PMCID: PMC10095245.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals Cells
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice. J Pharmacol Sci. 2023 May; 152(1):30-38. Wang H, Fukunaga K, Cheng A, Wang Y, Arimura N, Yoshino H, Sasaki T, Kawahata I. PMID: 37059489.

View in: PubMed Mentions: 2 Fields:
Pha Pharmacology
Translation:Animals Cells
α-Synuclein decoy peptide protects mice against α-synuclein-induced memory loss. CNS Neurosci Ther. 2023 06; 29(6):1547-1560. Guo Q, Kawahata I, Jia W, Wang H, Cheng A, Yabuki Y, Shioda N, Fukunaga K. PMID: 36786129; PMCID: PMC10173724.

View in: PubMed Mentions: 4 Fields:
Neu Neurology The Therapeutics
Translation:Animals Cells
Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons. Redox Biol. 2023 02; 59:102547. Guo Q, Kawahata I, Cheng A, Wang H, Jia W, Yoshino H, Fukunaga K. PMID: 36481733; PMCID: PMC9727700.

View in: PubMed Mentions: 5 Fields:
Cel Cell Biology Met Metabolism
Translation:Humans Animals Cells
Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets. Int J Mol Sci. 2022 Aug 25; 23(17). Guo Q, Kawahata I, Cheng A, Jia W, Wang H, Fukunaga K. PMID: 36077044; PMCID: PMC9455833.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals
[Role of fatty acid-binding protein 7 and novel therapeutic approach in synucleinopathies]. Nihon Yakurigaku Zasshi. 2022; 157(6):396-400. Cheng A, Fukunaga K. PMID: 36328545.

View in: PubMed Mentions: Fields:
Pha Pharmacology
Translation:Humans
A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models. EBioMedicine. 2021 Oct; 72:103582. Cheng A, Jia W, Kawahata I, Fukunaga K. PMID: 34624687; PMCID: PMC8502714.

View in: PubMed Mentions: 17 Fields:
Gen Genetics Med Medicine (General)
Translation:Humans Animals Cells
Hydroxyl-Directed Ruthenium-Catalyzed peri-Selective C-H Acylmethylation and Annulation of Naphthols with Sulfoxonium Ylides. Org Lett. 2021 Aug 20; 23(16):6200-6205. Ma W, Tan Y, Wang Y, Li Z, Li Z, Gu L, Mei R, Cheng A. PMID: 34339192.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy. Biomedicines. 2021 May 17; 9(5). Cheng A, Jia W, Kawahata I, Fukunaga K. PMID: 34067791; PMCID: PMC8156290.

View in: PubMed Mentions: 2
Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress. Acta Pharmacol Sin. 2022 Mar; 43(3):552-562. Cheng A, Wang YF, Shinoda Y, Kawahata I, Yamamoto T, Jia WB, Yamamoto H, Mizobata T, Kawata Y, Fukunaga K. PMID: 33935286; PMCID: PMC8888578.

View in: PubMed Mentions: 10 Fields:
Pha Pharmacology
Translation:Humans Animals Cells
The Role of CaMKII and ERK Signaling in Addiction. Int J Mol Sci. 2021 Mar 20; 22(6). Jia W, Kawahata I, Cheng A, Fukunaga K. PMID: 33804804; PMCID: PMC8004038.

View in: PubMed Mentions: 6 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans Animals Cells
Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/β-Catenin Signaling. Pharm Res. 2021 Mar; 38(3):479-490. Umaru BA, Kagawa Y, Shil SK, Arakawa N, Pan Y, Miyazaki H, Kobayashi S, Yang S, Cheng A, Wang Y, Shinoda Y, Kiniwa Y, Okuyama R, Fukunaga K, Owada Y. PMID: 33646504.

View in: PubMed Mentions: 8 Fields:
Pha Pharmacology
Translation:Humans Cells
Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress. Biomedicines. 2021 Jan 22; 9(2). Wang Y, Shinoda Y, Cheng A, Kawahata I, Fukunaga K. PMID: 33499263; PMCID: PMC7911662.

View in: PubMed Mentions: 7
Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice. Int J Mol Sci. 2021 Jan 13; 22(2). Yuan D, Cheng A, Kawahata I, Izumi H, Xu J, Fukunaga K. PMID: 33451040; PMCID: PMC7828528.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals Cells
Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice. Mol Neurobiol. 2021 May; 58(5):2030-2045. Jia W, Wilar G, Kawahata I, Cheng A, Fukunaga K. PMID: 33411237.

View in: PubMed Mentions: 7 Fields:
Mol Molecular Biology Neu Neurology
Translation:Animals Cells
Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes. Biomedicines. 2020 Dec 20; 8(12). Cheng A, Kawahata I, Fukunaga K. PMID: 33419250; PMCID: PMC7766880.

View in: PubMed Mentions: 10
Inhibition of MPTP-induced α-synuclein oligomerization by fatty acid-binding protein 3 ligand in MPTP-treated mice. Neuropharmacology. 2019 05 15; 150:164-174. Matsuo K, Cheng A, Yabuki Y, Takahata I, Miyachi H, Fukunaga K. PMID: 30930168.

View in: PubMed Mentions: 18 Fields:
Neu Neurology Pha Pharmacology
Translation:Animals Cells
Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization. Brain Res. 2019 03 15; 1707:190-197. Cheng A, Shinoda Y, Yamamoto T, Miyachi H, Fukunaga K. PMID: 30496735.

View in: PubMed Mentions: 24 Fields:
Bra Brain
Translation:Animals Cells