Jonah Chan, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-476-8557
ORCID ORCID Icon0000-0002-2176-1242 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of Illinois Urbana-ChampaignBSBiochemistry
    University of Illinois Urbana-ChampaignPhDNeuroscience
    Stanford UniversityPostdocNeurobiology
    Collapse Awards and Honors
    The McKnight Foundation2020McKnight Memory and Cognitive Disorders Award
    NIH/NINDS2019Landis Award for Outstanding Mentorship
    National MS Society2013Barancik Prize for Innovation in MS Research
    UCSF2010Debbie and Andy Rachleff Distinguished Professor of Neurology
    National MS Society2009Harry Weaver Neuroscience Award
    Baxter Foundation2006 The Donald E. and Delia B. Baxter Foundation Scholar
    National MS Society2004NMSS Career Transition Award
    NIH/NINDS2002NIH F32 Postdoctoral Fellowship
    Stanford University2000NIH Neurobiology Postdoctoral Training Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Jonah R. Chan received his BS in Biochemistry and PhD in Neuroscience at the University of Illinois at Urbana-Champaign. He completed a postdoctoral fellowship in the Department of Neurobiology at Stanford University with Dr. Eric Shooter. Jonah is currently the Debbie and Andy Rachleff Distinguished Professor of Neurology. He is a member of the Neuroscience Graduate Program, Vice Chief in the Division of Neuroimmunology and Glial Biology and Co-Director of the Innovation Program for Remyelination and Repair at UCSF.

    The Chan laboratory has a long-standing interest in fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Myelination is one of the most exquisite examples of cell-cell interaction found in nature and functions to maximize the efficiency and velocity of action potentials transmitted throughout the nervous system. While much has been learned about the global determinants that generate myelin-forming cells during development, the Chan laboratory is particularly interested in understanding how local environmental cues control the spatiotemporal regulation of differentiation and myelination, including both molecular and biophysical interactions. Identification of an environment that is conducive for myelination could have important implications for efforts aimed at promoting repair and remyelination in the nervous system.

    Current Laboratory Members:

    Trung Huynh, BS
    Lab Manager
    Trung.Huynh@ucsf.edu

    Sarah Raissi, PhD
    Postdoctoral Fellow
    sarah.raissi@ucsf.edu

    Wendy Xin, PhD
    Postdoctoral Fellow
    Wen.xin@ucsf.edu

    Monique Lillis, BS
    Graduate Student
    monique.lillis@ucsf.edu

    Albert Zhang, PhD
    Postdoctoral Fellow
    albert.zhang@ucsf.edu

    Sonia Nocera, PhD
    Postdoctoral Fellow
    sonia.nocera@ucsf.edu

    Sandy Chu, BA
    Research Assistant
    sandy.chu@ucsf.edu

    Lahin Lalani, BS
    Graduate Student
    lahin.lalani@ucsf.edu

    Collapse Research 
    Collapse Research Activities and Funding
    Cell-type, circuit and network mechanisms of adult oligodendrogenesis in memory storage and retrieval
    NIH R01MH125515Jul 2, 2021 - Apr 30, 2026
    Role: Co-Principal Investigator
    Neuropeptides as axonal determinants for oligodendrocyte differentiation and myelination
    NIH R01NS115746Dec 1, 2020 - Nov 30, 2025
    Role: Principal Investigator
    Functional Screening of GPCR Small Molecule Libraries for Remyelination Therapies
    NIH R01NS095889Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Somatodendritic Inhibition of Oligodendrocyte Myelination
    NIH R01NS097428Jun 1, 2016 - Feb 28, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2022 Jun 16. Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, Chan JR, Green AJ. PMID: 35710320.
      View in: PubMed   Mentions:    Fields:    
    2. Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy. Brain. 2022 Jun 09. Cordano C, Sin JH, Timmons G, Yiu HH, Stebbins K, Guglielmetti C, Cruz-Herranz A, Xin W, Lorrain D, Chan JR, Green AJ. PMID: 35678509.
      View in: PubMed   Mentions:    Fields:    
    3. A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial. Mult Scler Relat Disord. 2022 May; 61:103747. Bove R, Anderson A, Rowles W, Rankin KA, Hills NK, Carleton M, Cooper J, Cree BAC, Gelfand JM, Graves JS, Henry RG, Krysko KM, Rush G, Zamvil SS, Joffe H, Chan JR, Green AJ. PMID: 35397292.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    4. Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin. Neuron. 2021 11 17; 109(22):3619-3632.e5. Osso LA, Rankin KA, Chan JR. PMID: 34536353; PMCID: PMC8602781.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells. J Neurosci. 2021 10 20; 41(42):8710-8724. Follis RM, Tep C, Genaro-Mattos TC, Kim ML, Ryu JC, Morrison VE, Chan JR, Porter N, Carter BD, Yoon SO. PMID: 34507952; PMCID: PMC8528492.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Clinical Applications of Myelin Plasticity for Remyelinating Therapies in Multiple Sclerosis. Ann Neurol. 2021 10; 90(4):558-567. Pan S, Chan JR. PMID: 34402546; PMCID: PMC8555870.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation. Neuron. 2021 10 06; 109(19):3104-3118.e6. Niu J, Yu G, Wang X, Xia W, Wang Y, Hoi KK, Mei F, Xiao L, Chan JR, Fancy SPJ. PMID: 34390652; PMCID: PMC8547708.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease. Neuron. 2021 07 21; 109(14):2292-2307.e5. Chen JF, Liu K, Hu B, Li RR, Xin W, Chen H, Wang F, Chen L, Li RX, Ren SY, Xiao L, Chan JR, Mei F. PMID: 34102111; PMCID: PMC8298291.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    9. Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment. Elife. 2021 03 23; 10. Chen Y, Kunjamma RB, Weiner M, Chan JR, Popko B. PMID: 33752802; PMCID: PMC7987340.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells. Elife. 2021 03 10; 10. Chang KJ, Agrawal I, Vainshtein A, Ho WY, Xin W, Tucker-Kellogg G, Susuki K, Peles E, Ling SC, Chan JR. PMID: 33689679; PMCID: PMC7946431.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination. Neuron. 2021 04 21; 109(8):1258-1273. Pease-Raissi SE, Chan JR. PMID: 33621477; PMCID: PMC8068592.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Myelin plasticity: sculpting circuits in learning and memory. Nat Rev Neurosci. 2020 12; 21(12):682-694. Xin W, Chan JR. PMID: 33046886; PMCID: PMC8018611.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    13. Preservation of a remote fear memory requires new myelin formation. Nat Neurosci. 2020 04; 23(4):487-499. Pan S, Mayoral SR, Choi HS, Chan JR, Kheirbek MA. PMID: 32042175; PMCID: PMC7213814.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    14. Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory. Nat Neurosci. 2020 04; 23(4):481-486. Wang F, Ren SY, Chen JF, Liu K, Li RX, Li ZF, Hu B, Niu JQ, Xiao L, Chan JR, Mei F. PMID: 32042174; PMCID: PMC7306053.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    15. That Wasn't a Complement-Too Much C3 in Demyelinating Disease. Immunity. 2020 01 14; 52(1):11-13. Xin W, Chan JR. PMID: 31951547; PMCID: PMC8057118.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7. Nat Commun. 2019 07 05; 10(1):2976. Harty BL, Coelho F, Pease-Raissi SE, Mogha A, Ackerman SD, Herbert AL, Gereau RW, Golden JP, Lyons DA, Chan JR, Monk KR. PMID: 31278268; PMCID: PMC6611888.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. A surprising role for myelin in Williams syndrome. Nat Neurosci. 2019 05; 22(5):681-683. Osso LA, Chan JR. PMID: 31011225.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Nat Neurosci. 2019 05; 22(5):709-718. Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ. PMID: 30988524; PMCID: PMC6486410.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    19. Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors. J Neurosci. 2019 03 20; 39(12):2184-2194. Rankin KA, Mei F, Kim K, Shen YA, Mayoral SR, Desponts C, Lorrain DS, Green AJ, Baranzini SE, Chan JR, Bove R. PMID: 30696729; PMCID: PMC6433770.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber. Cell Rep. 2018 10 16; 25(3):544-550.e3. Mayoral SR, Etxeberria A, Shen YA, Chan JR. PMID: 30332636; PMCID: PMC6258034.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    21. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia. Neuron. 2018 08 22; 99(4):689-701.e5. Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ, Xiao L, Chan JR, Mei F. PMID: 30078577; PMCID: PMC6170028.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    22. The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner. Glia. 2018 09; 66(9):1947-1959. Jiang M, Rao R, Wang J, Wang J, Xu L, Wu LM, Chan JR, Wang H, Lu QR. PMID: 29722913; PMCID: PMC6185760.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand. Curr Biol. 2018 04 23; 28(8):1296-1305.e5. Almeida RG, Pan S, Cole KLH, Williamson JM, Early JJ, Czopka T, Klingseisen A, Chan JR, Lyons DA. PMID: 29628374; PMCID: PMC5912901.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    24. Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury. Brain. 2018 01 01; 141(1):85-98. Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ. PMID: 29244098; PMCID: PMC6394402.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    25. Micro(glial)-managing executive function: white matter inflammation drives catatonia. J Clin Invest. 2018 02 01; 128(2):564-566. Pease-Raissi SE, Chan JR. PMID: 29252213; PMCID: PMC5785255.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. Regulation and dysregulation of axon infrastructure by myelinating glia. J Cell Biol. 2017 12 04; 216(12):3903-3916. Pan S, Chan JR. PMID: 29114067; PMCID: PMC5716274.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    27. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804; PMCID: PMC5851281.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    28. Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial. Lancet. 2017 Dec 02; 390(10111):2481-2489. Green AJ, Gelfand JM, Cree BA, Bevan C, Boscardin WJ, Mei F, Inman J, Arnow S, Devereux M, Abounasr A, Nobuta H, Zhu A, Friessen M, Gerona R, von Büdingen HC, Henry RG, Hauser SL, Chan JR. PMID: 29029896.
      View in: PubMed   Mentions: 127     Fields:    Translation:Humans
    29. Mechanical plasticity during oligodendrocyte differentiation and myelination. Glia. 2018 01; 66(1):5-14. Domingues HS, Cruz A, Chan JR, Relvas JB, Rubinstein B, Pinto IM. PMID: 28940651; PMCID: PMC5743057.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    30. Architecting the myelin landscape. Curr Opin Neurobiol. 2017 12; 47:1-7. Osso LA, Chan JR. PMID: 28709021; PMCID: PMC5732869.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    31. Regulatory T cells promote myelin regeneration in the central nervous system. Nat Neurosci. 2017 May; 20(5):674-680. Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC. PMID: 28288125; PMCID: PMC5409501.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    32. Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. Elife. 2016 Sep 27; 5. Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. PMID: 27671734; PMCID: PMC5039026.
      View in: PubMed   Mentions: 93     Fields:    
    33. Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Neuron. 2016 Aug 17; 91(4):824-836. Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E, Chan JR. PMID: 27499083; PMCID: PMC4990461.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    34. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. PMID: 27466337; PMCID: PMC4961778.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    35. Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity. J Neurosci. 2016 06 29; 36(26):6937-48. Etxeberria A, Hokanson KC, Dao DQ, Mayoral SR, Mei F, Redmond SA, Ullian EM, Chan JR. PMID: 27358452; PMCID: PMC4926240.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    36. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. 2016 07 06; 91(1):41-55. Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ. PMID: 27321923; PMCID: PMC4938715.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    37. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat Neurosci. 2016 08; 19(8):1060-72. Wu LM, Wang J, Conidi A, Zhao C, Wang H, Ford Z, Zhang L, Zweier C, Ayee BG, Maurel P, Zwijsen A, Chan JR, Jankowski MP, Huylebroeck D, Lu QR. PMID: 27294509; PMCID: PMC4961522.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    38. The environment rules: spatiotemporal regulation of oligodendrocyte differentiation. Curr Opin Neurobiol. 2016 08; 39:47-52. Mayoral SR, Chan JR. PMID: 27128881; PMCID: PMC4987220.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    39. Remodeling myelination: implications for mechanisms of neural plasticity. Nat Neurosci. 2016 Feb; 19(2):190-7. Chang KJ, Redmond SA, Chan JR. PMID: 26814588; PMCID: PMC4792270.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    40. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016 Jan 22; 351(6271):379-84. Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP. PMID: 26798014; PMCID: PMC5472053.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    41. Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. J Neurosci. 2016 Jan 20; 36(3):806-13. Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, Casaccia P. PMID: 26791211; PMCID: PMC4719016.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    42. Astrocytes Underlie Neuroinflammatory Memory Impairment. Cell. 2015 Dec 17; 163(7):1574-6. Osso LA, Chan JR. PMID: 26687350; PMCID: PMC4786168.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    43. Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor. Biotechnol J. 2016 Mar; 11(3):425-36. Burns ML, Malott TM, Metcalf KJ, Puguh A, Chan JR, Shusta EV. PMID: 26580314.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    44. The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry. J Cell Biol. 2015 Sep 14; 210(6):891-8. von Büdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan JR. PMID: 26347141; PMCID: PMC4576870.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    45. Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent. Nat Commun. 2014 Sep 26; 5:4991. Shen YA, Chen Y, Dao DQ, Mayoral SR, Wu L, Meijer D, Ullian EM, Chan JR, Lu QR. PMID: 25255972; PMCID: PMC4334370.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    46. Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae. Appl Environ Microbiol. 2014 Sep; 80(18):5732-42. Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan JR, Shusta EV. PMID: 25015885; PMCID: PMC4178591.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    47. Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat Med. 2014 Aug; 20(8):954-960. Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJM, Green A, Hauser SL, Chan JR. PMID: 24997607; PMCID: PMC4830134.
      View in: PubMed   Mentions: 194     Fields:    Translation:AnimalsCells
    48. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. PMID: 24776795; PMCID: PMC4057936.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    49. Multiple sclerosis: Prospects and promise. Ann Neurol. 2013 Sep; 74(3):317-27. Hauser SL, Chan JR, Oksenberg JR. PMID: 23955638.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    50. Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes. J Neurosci. 2013 May 08; 33(19):8454-62. Mei F, Wang H, Liu S, Niu J, Wang L, He Y, Etxeberria A, Chan JR, Xiao L. PMID: 23658182; PMCID: PMC3865513.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    51. A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers. Nat Protoc. 2013 Apr; 8(4):771-82. Lee S, Chong SY, Tuck SJ, Corey JM, Chan JR. PMID: 23589937; PMCID: PMC5190508.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    52. Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration. Neurosci Bull. 2013 Apr; 29(2):177-88. Mei F, Christin Chong SY, Chan JR. PMID: 23516141; PMCID: PMC5190510.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    53. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013 Jan 17; 152(1-2):248-61. Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR. PMID: 23332759; PMCID: PMC3553550.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    54. Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development. Sci Signal. 2012 Sep 25; 5(243):ra69. Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan JR, Tsujimoto G, Tanoue A. PMID: 23012656.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    55. A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods. 2012 Sep; 9(9):917-22. Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR. PMID: 22796663; PMCID: PMC3433633.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    56. Neuroscience. Revitalizing remyelination--the answer is circulating. Science. 2012 Apr 13; 336(6078):161-2. Redmond SA, Chan JR. PMID: 22499927.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    57. Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1299-304. Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR. PMID: 22160722; PMCID: PMC3268264.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    58. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012 Jan 06; 287(2):1600-8. Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. PMID: 22128191; PMCID: PMC3256919.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    59. Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination. J Neurosci. 2011 Feb 23; 31(8):3032-43. Lewallen KA, Shen YA, De la Torre AR, Ng BK, Meijer D, Chan JR. PMID: 21414924; PMCID: PMC3758556.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    60. Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011; 34:21-43. Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH. PMID: 21692657.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    61. Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis. Nat Protoc. 2010 Aug; 5(8):1396-405. Kim YE, Chen J, Langen R, Chan JR. PMID: 20671723; PMCID: PMC4340478.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    62. Tapping into the glial reservoir: cells committed to remaining uncommitted. J Cell Biol. 2010 Feb 08; 188(3):305-12. Chong SY, Chan JR. PMID: 20142420; PMCID: PMC2819683.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    63. Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration. Nat Methods. 2010 Jan; 7(1):67-73. Kim YE, Chen J, Chan JR, Langen R. PMID: 19966809; PMCID: PMC2846705.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    64. A collaboration conducive to conduction: matching axonal density to oligodendroglial number (Commentary on Kawai et al.). Eur J Neurosci. 2009 Dec 03; 30(11):2029. Hahn AT, Chan JR. PMID: 20128841.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    65. Modulating myelination: knowing when to say Wnt. Genes Dev. 2009 Jul 01; 23(13):1487-93. Rosenberg SS, Chan JR. PMID: 19571178; PMCID: PMC4419287.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    66. The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14662-7. Rosenberg SS, Kelland EE, Tokar E, De la Torre AR, Chan JR. PMID: 18787118; PMCID: PMC2567234.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    67. ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol. 2008 Apr 21; 181(2):351-65. Yamauchi J, Miyamoto Y, Chan JR, Tanoue A. PMID: 18426980; PMCID: PMC2315680.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    68. Receiving mixed signals: uncoupling oligodendrocyte differentiation and myelination. Cell Mol Life Sci. 2007 Dec; 64(23):3059-68. Rosenberg SS, Powell BL, Chan JR. PMID: 17876524.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    69. Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. J Cell Sci. 2007 Dec 15; 120(Pt 24):4355-66. Miyamoto Y, Yamauchi J, Chan JR, Okada A, Tomooka Y, Hisanaga S, Tanoue A. PMID: 18042622.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    70. Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination. J Neurosci. 2007 Jul 11; 27(28):7597-603. Ng BK, Chen L, Mandemakers W, Cosgaya JM, Chan JR. PMID: 17626221; PMCID: PMC6672611.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    71. Myelination: all about Rac 'n' roll. J Cell Biol. 2007 Jun 18; 177(6):953-5. Chan JR. PMID: 17576794; PMCID: PMC2064356.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    72. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J Neurosci. 2007 Jan 03; 27(1):220-5. Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu M, Miller RH, Chan JR, Mi S. PMID: 17202489; PMCID: PMC6672289.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    73. The polarity protein Par-3 directly interacts with p75NTR to regulate myelination. Science. 2006 Nov 03; 314(5800):832-6. Chan JR, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M. PMID: 17082460.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    74. The quest for remyelination: a new role for neurotrophins and their receptors. Brain Pathol. 2006 Oct; 16(4):288-94. Rosenberg SS, Ng BK, Chan JR. PMID: 17107598; PMCID: PMC8095791.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    75. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14889-94. Yamauchi J, Miyamoto Y, Tanoue A, Shooter EM, Chan JR. PMID: 16203995; PMCID: PMC1253593.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    76. The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5198-203. Yamauchi J, Chan JR, Miyamoto Y, Tsujimoto G, Shooter EM. PMID: 15758069; PMCID: PMC556009.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    77. Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking. Mol Cell Neurosci. 2005 Mar; 28(3):571-87. Saxena S, Howe CL, Cosgaya JM, Steiner P, Hirling H, Chan JR, Weis J, Krüttgen A. PMID: 15737746.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    78. NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron. 2004 Jul 22; 43(2):183-91. Chan JR, Watkins TA, Cosgaya JM, Zhang C, Chen L, Reichardt LF, Shooter EM, Barres BA. PMID: 15260955; PMCID: PMC2758239.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    79. Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8774-9. Yamauchi J, Chan JR, Shooter EM. PMID: 15161978; PMCID: PMC423271.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    80. Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 are sorted to dense-core vesicles and released via the regulated pathway in primary rat cortical neurons. J Neurosci Res. 2004 Mar 15; 75(6):825-34. Wu YJ, Krüttgen A, Möller JC, Shine D, Chan JR, Shooter EM, Cosgaya JM. PMID: 14994343.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    81. Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture. Mol Cell Neurosci. 2004 Feb; 25(2):241-51. Ullian EM, Harris BT, Wu A, Chan JR, Barres BA. PMID: 15019941.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    82. Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14421-6. Yamauchi J, Chan JR, Shooter EM. PMID: 14614136; PMCID: PMC283607.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    83. The neurotrophin receptor p75NTR as a positive modulator of myelination. Science. 2002 Nov 08; 298(5596):1245-8. Cosgaya JM, Chan JR, Shooter EM. PMID: 12424382.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    84. Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14661-8. Chan JR, Cosgaya JM, Wu YJ, Shooter EM. PMID: 11717413; PMCID: PMC64738.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    85. Progesterone synthesized by Schwann cells during myelin formation regulates neuronal gene expression. Mol Biol Cell. 2000 Jul; 11(7):2283-95. Chan JR, Rodriguez-Waitkus PM, Ng BK, Liang P, Glaser M. PMID: 10888668; PMCID: PMC14919.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    86. Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10459-64. Chan JR, Phillips LJ, Glaser M. PMID: 9724725; PMCID: PMC27916.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    87. Measurement of the rate of myelination using a fluorescent analogue of ceramide. J Neurosci Res. 1997 Aug 15; 49(4):497-507. Bilderback TR, Chan JR, Harvey JJ, Glaser M. PMID: 9285525.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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