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Jonah Chan, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-514-9818
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    Collapse Biography 
    Collapse Education and Training
    University of Illinois Urbana-ChampaignBSBiochemistry
    University of Illinois Urbana-ChampaignPhDNeuroscience
    Stanford UniversityPostdocNeurobiology
    Collapse Awards and Honors
    NMSS2013Barancik Prize
    UCSF2010Debbie and Andy Rachleff Professor of Neurology
    NMSS2009Harry Weaver Neuroscience Award
    Baxter Foundation2006Baxter Foundation Scholar
    NMSS2004Career Transition Award
    NIH2002NRSA Postdoctoral Fellowship
    University of Illinois1994Honors Graduate, Department of Biochemistry
    University of Illinois1994Sidebottom Award for Outstanding Honors Thesis
    Monsanto1993Monsanto Biotechnology Research Award

    Collapse Overview 
    Collapse Overview
    Dr. Jonah R. Chan received his BS in Biochemistry and PhD in Neuroscience at the University of Illinois at Urbana-Champaign. He completed a postdoctoral fellowship in the Department of Neurobiology at Stanford University with Dr. Eric Shooter. Jonah is currently the Debbie and Andy Rachleff Distinguished Professor of Neurology. He is a member of the Neuroscience Graduate Program and the MS Research Center at UCSF.

    The Chan laboratory has a long-standing interest in fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Myelination is one of the most exquisite examples of cell-cell interaction found in nature and functions to maximize the efficiency and velocity of action potentials transmitted throughout the nervous system. While much has been learned about the global determinants that generate myelin-forming cells during development, the Chan laboratory is particularly interested in understanding how local environmental cues control the spatiotemporal regulation of differentiation and myelination, including both molecular and biophysical interactions. Identification of an environment that is conducive for myelination could have important implications for efforts aimed at promoting repair and remyelination in the nervous system.

    Current Laboratory Members:

    Trung Huynh, BS
    Lab Manager
    Trung.Huynh@ucsf.edu

    Sonia Mayoral, PhD
    Postdoctoral Fellow
    sonia.mayoral@ucsf.edu

    Kae-Jiun Chang, PhD
    Postdoctoral Fellow
    kae-jiun.chang@ucsf.edu

    Lindsay Osso, BS
    Graduate Student
    lindsay.osso@ucsf.edu

    Simon Pan, BS
    MSTP Graduate Student
    simon.pan.808@gmail.com

    Kelsey Rankin, BS
    Assistant Specialist
    kelseyrankin11@gmail.com

    Sarah Raissi, PhD
    Postdoctoral Fellow
    sarah.raissi@ucsf.edu


    Collapse Research 
    Collapse Research Activities and Funding
    Functional Screening of GPCR Small Molecule Libraries for Remyelination Therapies
    NIH/NINDS R01NS095889Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Somatodendritic Inhibition of Oligodendrocyte Myelination
    NIH/NINDS R01NS097428Jun 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    The establishment of Schwann cell polarity and the initiation of myelination
    NIH/NINDS R01NS062796Jul 15, 2008 - Apr 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pan S, Chan J. Regulation and dysregulation of axon infrastructure by myelinating glia. J Cell Biol. 2017 Nov 07. PMID: 29114067.
      View in: PubMed
    2. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan J, Akassoglou K. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Oct 19. PMID: 29103804.
      View in: PubMed
    3. Green AJ, Gelfand JM, Cree BA, Bevan C, Boscardin WJ, Mei F, Inman J, Arnow S, Devereux M, Abounasr A, Nobuta H, Zhu A, Friessen M, Gerona R, von Büdingen HC, Henry RG, Hauser SL, Chan J. Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial. Lancet. 2017 Oct 10. PMID: 29029896.
      View in: PubMed
    4. Domingues HS, Cruz A, Chan J, Relvas JB, Rubinstein B, Pinto IM. Mechanical plasticity during oligodendrocyte differentiation and myelination. Glia. 2017 Sep 21. PMID: 28940651.
      View in: PubMed
    5. Osso LA, Chan J. Architecting the myelin landscape. Curr Opin Neurobiol. 2017 Jul 11; 47:1-7. PMID: 28709021.
      View in: PubMed
    6. Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan J, Franklin RJ, Fitzgerald DC. Regulatory T cells promote myelin regeneration in the central nervous system. Nat Neurosci. 2017 May; 20(5):674-680. PMID: 28288125.
      View in: PubMed
    7. Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan J, et al. Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. Elife. 2016 Sep 27; 5. PMID: 27671734.
      View in: PubMed
    8. Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E, Chan J, et al. Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Neuron. 2016 Aug 17; 91(4):824-836. PMID: 27499083; PMCID: PMC4990461 [Available on 08/17/17].
    9. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan J. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 Jul 27; 36(30):7925-35. PMID: 27466337; PMCID: PMC4961778 [Available on 01/27/17].
    10. Etxeberria A, Hokanson KC, Dao DQ, Mayoral SR, Mei F, Redmond SA, Ullian EM, Chan J. Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity. J Neurosci. 2016 Jun 29; 36(26):6937-48. PMID: 27358452; PMCID: PMC4926240 [Available on 12/29/16].
    11. Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan J, Huang EJ, et al. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. 2016 Jul 06; 91(1):41-55. PMID: 27321923; PMCID: PMC4938715 [Available on 07/06/17].
    12. Wu LM, Wang J, Conidi A, Zhao C, Wang H, Ford Z, Zhang L, Zweier C, Ayee BG, Maurel P, Zwijsen A, Chan J, Jankowski MP, Huylebroeck D, Lu QR, et al. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat Neurosci. 2016 Aug; 19(8):1060-72. PMID: 27294509; PMCID: PMC4961522 [Available on 12/13/16].
    13. Mayoral SR, Chan J. The environment rules: spatiotemporal regulation of oligodendrocyte differentiation. Curr Opin Neurobiol. 2016 Aug; 39:47-52. PMID: 27128881; PMCID: PMC4987220 [Available on 08/01/17].
    14. Chang KJ, Redmond SA, Chan J. Remodeling myelination: implications for mechanisms of neural plasticity. Nat Neurosci. 2016 Feb; 19(2):190-7. PMID: 26814588; PMCID: PMC4792270.
    15. Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan J, Daneman R, Fancy SP. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016 Jan 22; 351(6271):379-84. PMID: 26798014.
      View in: PubMed
    16. Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan J, Casaccia P. Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. J Neurosci. 2016 Jan 20; 36(3):806-13. PMID: 26791211; PMCID: PMC4719016.
    17. Osso LA, Chan J. Astrocytes Underlie Neuroinflammatory Memory Impairment. Cell. 2015 Dec 17; 163(7):1574-6. PMID: 26687350; PMCID: PMC4786168.
    18. Burns ML, Malott TM, Metcalf KJ, Puguh A, Chan J, Shusta EV. Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor. Biotechnol J. 2016 Mar; 11(3):425-36. PMID: 26580314.
      View in: PubMed
    19. von Büdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan J. The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry. J Cell Biol. 2015 Sep 14; 210(6):891-8. PMID: 26347141; PMCID: PMC4576870.
    20. Shen YA, Chen Y, Dao DQ, Mayoral SR, Wu L, Meijer D, Ullian EM, Chan J, Lu QR. Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent. Nat Commun. 2014 Sep 26; 5:4991. PMID: 25255972; PMCID: PMC4334370.
    21. Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan J, Shusta EV. Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae. Appl Environ Microbiol. 2014 Sep; 80(18):5732-42. PMID: 25015885; PMCID: PMC4178591.
    22. Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan J, Shusta EV. Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan JR, Shusta EV. Directed Evolution of Brain-Derived Neurotrophic Factor for Improved Folding and Expression in Saccharomyces cerevisiae. Appl Environ Microbiol. 2014 Sep 15; 80(18):5732-42. PMID: 25015885.
      View in: PubMed
    23. Mei F, Fancy SP, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJ, Green A, Hauser SL, Chan J. Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat Med. 2014 Aug; 20(8):954-960. PMID: 24997607; PMCID: PMC4830134.
    24. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan J, Baranzini SE, Ullian EM, Rowitch DH. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. PMID: 24776795; PMCID: PMC4057936.
    25. Hauser SL, Chan J, Oksenberg JR. Multiple sclerosis: Prospects and promise. Ann Neurol. 2013 Sep; 74(3):317-27. PMID: 23955638.
      View in: PubMed
    26. Mei F, Wang H, Liu S, Niu J, Wang L, He Y, Etxeberria A, Chan J, Xiao L. Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes. J Neurosci. 2013 May 08; 33(19):8454-62. PMID: 23658182; PMCID: PMC3865513.
    27. Lee S, Chong SY, Tuck SJ, Corey JM, Chan J. A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers. Nat Protoc. 2013 Apr; 8(4):771-82. PMID: 23589937.
      View in: PubMed
    28. Mei F, Christin Chong SY, Chan J. Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration. Neurosci Bull. 2013 Apr; 29(2):177-88. PMID: 23516141.
      View in: PubMed
    29. Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan J, Wu J, Lu QR. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013 Jan 17; 152(1-2):248-61. PMID: 23332759; PMCID: PMC3553550.
    30. Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan J, Tsujimoto G, Tanoue A. Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development. Sci Signal. 2012 Sep 25; 5(243):ra69. PMID: 23012656.
      View in: PubMed
    31. Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan J. A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods. 2012 Sep; 9(9):917-22. PMID: 22796663; PMCID: PMC3433633.
    32. Redmond SA, Chan J. Neuroscience. Revitalizing remyelination--the answer is circulating. Science. 2012 Apr 13; 336(6078):161-2. PMID: 22499927.
      View in: PubMed
    33. Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan J. Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1299-304. PMID: 22160722; PMCID: PMC3268264.
    34. Tep C, Kim ML, Opincariu LI, Limpert AS, Chan J, Appel B, Carter BD, Yoon SO. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012 Jan 06; 287(2):1600-8. PMID: 22128191; PMCID: PMC3256919.
    35. Lewallen KA, Shen YA, De la Torre AR, Ng BK, Meijer D, Chan J. Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination. J Neurosci. 2011 Feb 23; 31(8):3032-43. PMID: 21414924; PMCID: PMC3758556.
    36. Fancy SP, Chan J, Baranzini SE, Franklin RJ, Rowitch DH. Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011; 34:21-43. PMID: 21692657.
      View in: PubMed
    37. Kim YE, Chen J, Langen R, Chan J. Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis. Nat Protoc. 2010 Aug; 5(8):1396-405. PMID: 20671723; PMCID: PMC4340478.
    38. Chong SY, Chan J. Tapping into the glial reservoir: cells committed to remaining uncommitted. J Cell Biol. 2010 Feb 08; 188(3):305-12. PMID: 20142420; PMCID: PMC2819683.
    39. Kim YE, Chen J, Chan J, Langen R. Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration. Nat Methods. 2010 Jan; 7(1):67-73. PMID: 19966809; PMCID: PMC2846705.
    40. Hahn AT, Chan J. A collaboration conducive to conduction: matching axonal density to oligodendroglial number (Commentary on Kawai et al.). Eur J Neurosci. 2009 Dec 03; 30(11):2029. PMID: 20128841.
      View in: PubMed
    41. Rosenberg SS, Chan J. Modulating myelination: knowing when to say Wnt. Genes Dev. 2009 Jul 01; 23(13):1487-93. PMID: 19571178; PMCID: PMC4419287.
    42. Rosenberg SS, Kelland EE, Tokar E, De la Torre AR, Chan J. The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14662-7. PMID: 18787118; PMCID: PMC2567234.
    43. Yamauchi J, Miyamoto Y, Chan J, Tanoue A. ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol. 2008 Apr 21; 181(2):351-65. PMID: 18426980; PMCID: PMC2315680.
    44. Rosenberg SS, Powell BL, Chan J. Receiving mixed signals: uncoupling oligodendrocyte differentiation and myelination. Cell Mol Life Sci. 2007 Dec; 64(23):3059-68. PMID: 17876524.
      View in: PubMed
    45. Miyamoto Y, Yamauchi J, Chan J, Okada A, Tomooka Y, Hisanaga S, Tanoue A. Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. J Cell Sci. 2007 Dec 15; 120(Pt 24):4355-66. PMID: 18042622.
      View in: PubMed
    46. Ng BK, Chen L, Mandemakers W, Cosgaya JM, Chan J. Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination. J Neurosci. 2007 Jul 11; 27(28):7597-603. PMID: 17626221.
      View in: PubMed
    47. Chan J. Myelination: all about Rac 'n' roll. J Cell Biol. 2007 Jun 18; 177(6):953-5. PMID: 17576794; PMCID: PMC2064356.
    48. Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu M, Miller RH, Chan J, Mi S. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J Neurosci. 2007 Jan 03; 27(1):220-5. PMID: 17202489.
      View in: PubMed
    49. Chan J, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M. The polarity protein Par-3 directly interacts with p75NTR to regulate myelination. Science. 2006 Nov 03; 314(5800):832-6. PMID: 17082460.
      View in: PubMed
    50. Rosenberg SS, Ng BK, Chan J. The quest for remyelination: a new role for neurotrophins and their receptors. Brain Pathol. 2006 Oct; 16(4):288-94. PMID: 17107598.
      View in: PubMed
    51. Yamauchi J, Miyamoto Y, Tanoue A, Shooter EM, Chan J. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14889-94. PMID: 16203995; PMCID: PMC1253593.
    52. Yamauchi J, Chan J, Miyamoto Y, Tsujimoto G, Shooter EM. The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5198-203. PMID: 15758069; PMCID: PMC556009.
    53. Saxena S, Howe CL, Cosgaya JM, Steiner P, Hirling H, Chan J, Weis J, Krüttgen A. Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking. Mol Cell Neurosci. 2005 Mar; 28(3):571-87. PMID: 15737746.
      View in: PubMed
    54. Chan J, Watkins TA, Cosgaya JM, Zhang C, Chen L, Reichardt LF, Shooter EM, Barres BA. NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron. 2004 Jul 22; 43(2):183-91. PMID: 15260955; PMCID: PMC2758239.
    55. Yamauchi J, Chan J, Shooter EM. Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8774-9. PMID: 15161978; PMCID: PMC423271.
    56. Wu YJ, Krüttgen A, Möller JC, Shine D, Chan J, Shooter EM, Cosgaya JM. Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 are sorted to dense-core vesicles and released via the regulated pathway in primary rat cortical neurons. J Neurosci Res. 2004 Mar 15; 75(6):825-34. PMID: 14994343.
      View in: PubMed
    57. Ullian EM, Harris BT, Wu A, Chan J, Barres BA. Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture. Mol Cell Neurosci. 2004 Feb; 25(2):241-51. PMID: 15019941.
      View in: PubMed
    58. Yamauchi J, Chan J, Shooter EM. Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14421-6. PMID: 14614136; PMCID: PMC283607.
    59. Cosgaya JM, Chan J, Shooter EM. The neurotrophin receptor p75NTR as a positive modulator of myelination. Science. 2002 Nov 08; 298(5596):1245-8. PMID: 12424382.
      View in: PubMed
    60. Chan J, Cosgaya JM, Wu YJ, Shooter EM. Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14661-8. PMID: 11717413; PMCID: PMC64738.
    61. Chan J, Rodriguez-Waitkus PM, Ng BK, Liang P, Glaser M. Progesterone synthesized by Schwann cells during myelin formation regulates neuronal gene expression. Mol Biol Cell. 2000 Jul; 11(7):2283-95. PMID: 10888668; PMCID: PMC14919.
    62. Chan J, Phillips LJ, Glaser M. Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10459-64. PMID: 9724725; PMCID: PMC27916.
    63. Bilderback TR, Chan J, Harvey JJ, Glaser M. Measurement of the rate of myelination using a fluorescent analogue of ceramide. J Neurosci Res. 1997 Aug 15; 49(4):497-507. PMID: 9285525.
      View in: PubMed
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