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Remyelination by preexisting oligodendrocytes: Glass half full or half empty? Neuron. 2023 Jun 07; 111(11):1689-1691.
Nocera S, Chan JR. PMID: 37290399.
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PubMed Mentions: Fields:
Translation:
Cells
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Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response. Glia. 2023 09; 71(9):2180-2195.
Chen Y, Quan S, Patil V, Kunjamma RB, Tokars HM, Leisten ED, Joy G, Wills S, Chan JR, Wong YC, Popko B. PMID: 37203250.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial. Proc Natl Acad Sci U S A. 2023 05 16; 120(20):e2217635120.
Caverzasi E, Papinutto N, Cordano C, Kirkish G, Gundel TJ, Zhu A, Akula AV, Boscardin WJ, Neeb H, Henry RG, Chan JR, Green AJ. PMID: 37155847; PMCID: PMC10193980.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy. Brain. 2022 11 21; 145(11):3943-3952.
Cordano C, Sin JH, Timmons G, Yiu HH, Stebbins K, Guglielmetti C, Cruz-Herranz A, Xin W, Lorrain D, Chan JR, Green AJ. PMID: 35678509; PMCID: PMC10200282.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Motor learning revamps the myelin landscape. Nat Neurosci. 2022 10; 25(10):1251-1252.
Xin W, Chan JR. PMID: 36180789.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2022 Jun 16.
Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, Chan JR, Green AJ. PMID: 35710320; PMCID: PMC9984688.
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PubMed Mentions:
1 Fields:
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A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial. Mult Scler Relat Disord. 2022 May; 61:103747.
Bove R, Anderson A, Rowles W, Rankin KA, Hills NK, Carleton M, Cooper J, Cree BAC, Gelfand JM, Graves JS, Henry RG, Krysko KM, Rush G, Zamvil SS, Joffe H, Chan JR, Green AJ. PMID: 35397292.
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PubMed Mentions: Fields:
Translation:
HumansCTClinical Trials
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Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin. Neuron. 2021 11 17; 109(22):3619-3632.e5.
Osso LA, Rankin KA, Chan JR. PMID: 34536353; PMCID: PMC8602781.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells. J Neurosci. 2021 10 20; 41(42):8710-8724.
Follis RM, Tep C, Genaro-Mattos TC, Kim ML, Ryu JC, Morrison VE, Chan JR, Porter N, Carter BD, Yoon SO. PMID: 34507952; PMCID: PMC8528492.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Clinical Applications of Myelin Plasticity for Remyelinating Therapies in Multiple Sclerosis. Ann Neurol. 2021 10; 90(4):558-567.
Pan S, Chan JR. PMID: 34402546; PMCID: PMC8555870.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation. Neuron. 2021 10 06; 109(19):3104-3118.e6.
Niu J, Yu G, Wang X, Xia W, Wang Y, Hoi KK, Mei F, Xiao L, Chan JR, Fancy SPJ. PMID: 34390652; PMCID: PMC8547708.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease. Neuron. 2021 07 21; 109(14):2292-2307.e5.
Chen JF, Liu K, Hu B, Li RR, Xin W, Chen H, Wang F, Chen L, Li RX, Ren SY, Xiao L, Chan JR, Mei F. PMID: 34102111; PMCID: PMC8298291.
View in:
PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment. Elife. 2021 03 23; 10.
Chen Y, Kunjamma RB, Weiner M, Chan JR, Popko B. PMID: 33752802; PMCID: PMC7987340.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells. Elife. 2021 03 10; 10.
Chang KJ, Agrawal I, Vainshtein A, Ho WY, Xin W, Tucker-Kellogg G, Susuki K, Peles E, Ling SC, Chan JR. PMID: 33689679; PMCID: PMC7946431.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination. Neuron. 2021 04 21; 109(8):1258-1273.
Pease-Raissi SE, Chan JR. PMID: 33621477; PMCID: PMC8068592.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Myelin plasticity: sculpting circuits in learning and memory. Nat Rev Neurosci. 2020 12; 21(12):682-694.
Xin W, Chan JR. PMID: 33046886; PMCID: PMC8018611.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Preservation of a remote fear memory requires new myelin formation. Nat Neurosci. 2020 04; 23(4):487-499.
Pan S, Mayoral SR, Choi HS, Chan JR, Kheirbek MA. PMID: 32042175; PMCID: PMC7213814.
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PubMed Mentions:
109 Fields:
Translation:
AnimalsCells
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Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory. Nat Neurosci. 2020 04; 23(4):481-486.
Wang F, Ren SY, Chen JF, Liu K, Li RX, Li ZF, Hu B, Niu JQ, Xiao L, Chan JR, Mei F. PMID: 32042174; PMCID: PMC7306053.
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PubMed Mentions:
104 Fields:
Translation:
AnimalsCells
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That Wasn't a Complement-Too Much C3 in Demyelinating Disease. Immunity. 2020 01 14; 52(1):11-13.
Xin W, Chan JR. PMID: 31951547; PMCID: PMC8057118.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7. Nat Commun. 2019 07 05; 10(1):2976.
Harty BL, Coelho F, Pease-Raissi SE, Mogha A, Ackerman SD, Herbert AL, Gereau RW, Golden JP, Lyons DA, Chan JR, Monk KR. PMID: 31278268; PMCID: PMC6611888.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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A surprising role for myelin in Williams syndrome. Nat Neurosci. 2019 05; 22(5):681-683.
Osso LA, Chan JR. PMID: 31011225.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Nat Neurosci. 2019 05; 22(5):709-718.
Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ. PMID: 30988524; PMCID: PMC6486410.
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PubMed Mentions:
75 Fields:
Translation:
HumansAnimalsCells
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Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors. J Neurosci. 2019 03 20; 39(12):2184-2194.
Rankin KA, Mei F, Kim K, Shen YA, Mayoral SR, Desponts C, Lorrain DS, Green AJ, Baranzini SE, Chan JR, Bove R. PMID: 30696729; PMCID: PMC6433770.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber. Cell Rep. 2018 10 16; 25(3):544-550.e3.
Mayoral SR, Etxeberria A, Shen YA, Chan JR. PMID: 30332636; PMCID: PMC6258034.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia. Neuron. 2018 08 22; 99(4):689-701.e5.
Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ, Xiao L, Chan JR, Mei F. PMID: 30078577; PMCID: PMC6170028.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner. Glia. 2018 09; 66(9):1947-1959.
Jiang M, Rao R, Wang J, Wang J, Xu L, Wu LM, Chan JR, Wang H, Lu QR. PMID: 29722913; PMCID: PMC6185760.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand. Curr Biol. 2018 04 23; 28(8):1296-1305.e5.
Almeida RG, Pan S, Cole KLH, Williamson JM, Early JJ, Czopka T, Klingseisen A, Chan JR, Lyons DA. PMID: 29628374; PMCID: PMC5912901.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury. Brain. 2018 01 01; 141(1):85-98.
Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ. PMID: 29244098; PMCID: PMC6394402.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Micro(glial)-managing executive function: white matter inflammation drives catatonia. J Clin Invest. 2018 02 01; 128(2):564-566.
Pease-Raissi SE, Chan JR. PMID: 29252213; PMCID: PMC5785255.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Regulation and dysregulation of axon infrastructure by myelinating glia. J Cell Biol. 2017 12 04; 216(12):3903-3916.
Pan S, Chan JR. PMID: 29114067; PMCID: PMC5716274.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7.
Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804; PMCID: PMC5851281.
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PubMed Mentions:
72 Fields:
Translation:
AnimalsCells
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Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial. Lancet. 2017 Dec 02; 390(10111):2481-2489.
Green AJ, Gelfand JM, Cree BA, Bevan C, Boscardin WJ, Mei F, Inman J, Arnow S, Devereux M, Abounasr A, Nobuta H, Zhu A, Friessen M, Gerona R, von Büdingen HC, Henry RG, Hauser SL, Chan JR. PMID: 29029896.
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PubMed Mentions:
161 Fields:
Translation:
Humans
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Mechanical plasticity during oligodendrocyte differentiation and myelination. Glia. 2018 01; 66(1):5-14.
Domingues HS, Cruz A, Chan JR, Relvas JB, Rubinstein B, Pinto IM. PMID: 28940651; PMCID: PMC5743057.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Architecting the myelin landscape. Curr Opin Neurobiol. 2017 12; 47:1-7.
Osso LA, Chan JR. PMID: 28709021; PMCID: PMC5732869.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Regulatory T cells promote myelin regeneration in the central nervous system. Nat Neurosci. 2017 May; 20(5):674-680.
Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC. PMID: 28288125; PMCID: PMC5409501.
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PubMed Mentions:
178 Fields:
Translation:
AnimalsCells
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Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. Elife. 2016 Sep 27; 5.
Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. PMID: 27671734; PMCID: PMC5039026.
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PubMed Mentions:
115 Fields:
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Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Neuron. 2016 Aug 17; 91(4):824-836.
Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E, Chan JR. PMID: 27499083; PMCID: PMC4990461.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35.
Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. PMID: 27466337; PMCID: PMC4961778.
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PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity. J Neurosci. 2016 06 29; 36(26):6937-48.
Etxeberria A, Hokanson KC, Dao DQ, Mayoral SR, Mei F, Redmond SA, Ullian EM, Chan JR. PMID: 27358452; PMCID: PMC4926240.
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PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
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Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. 2016 07 06; 91(1):41-55.
Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ. PMID: 27321923; PMCID: PMC4938715.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat Neurosci. 2016 08; 19(8):1060-72.
Wu LM, Wang J, Conidi A, Zhao C, Wang H, Ford Z, Zhang L, Zweier C, Ayee BG, Maurel P, Zwijsen A, Chan JR, Jankowski MP, Huylebroeck D, Lu QR. PMID: 27294509; PMCID: PMC4961522.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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The environment rules: spatiotemporal regulation of oligodendrocyte differentiation. Curr Opin Neurobiol. 2016 08; 39:47-52.
Mayoral SR, Chan JR. PMID: 27128881; PMCID: PMC4987220.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Remodeling myelination: implications for mechanisms of neural plasticity. Nat Neurosci. 2016 Feb; 19(2):190-7.
Chang KJ, Redmond SA, Chan JR. PMID: 26814588; PMCID: PMC4792270.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
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Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016 Jan 22; 351(6271):379-84.
Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP. PMID: 26798014; PMCID: PMC5472053.
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PubMed Mentions:
166 Fields:
Translation:
HumansAnimalsCells
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Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. J Neurosci. 2016 Jan 20; 36(3):806-13.
Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, Casaccia P. PMID: 26791211; PMCID: PMC4719016.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Astrocytes Underlie Neuroinflammatory Memory Impairment. Cell. 2015 Dec 17; 163(7):1574-6.
Osso LA, Chan JR. PMID: 26687350; PMCID: PMC4786168.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor. Biotechnol J. 2016 Mar; 11(3):425-36.
Burns ML, Malott TM, Metcalf KJ, Puguh A, Chan JR, Shusta EV. PMID: 26580314.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry. J Cell Biol. 2015 Sep 14; 210(6):891-8.
von Büdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan JR. PMID: 26347141; PMCID: PMC4576870.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent. Nat Commun. 2014 Sep 26; 5:4991.
Shen YA, Chen Y, Dao DQ, Mayoral SR, Wu L, Meijer D, Ullian EM, Chan JR, Lu QR. PMID: 25255972; PMCID: PMC4334370.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae. Appl Environ Microbiol. 2014 Sep; 80(18):5732-42.
Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan JR, Shusta EV. PMID: 25015885; PMCID: PMC4178591.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat Med. 2014 Aug; 20(8):954-960.
Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJM, Green A, Hauser SL, Chan JR. PMID: 24997607; PMCID: PMC4830134.
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PubMed Mentions:
219 Fields:
Translation:
AnimalsCells
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Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94.
Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. PMID: 24776795; PMCID: PMC4057936.
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PubMed Mentions:
154 Fields:
Translation:
HumansAnimalsCells
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Multiple sclerosis: Prospects and promise. Ann Neurol. 2013 Sep; 74(3):317-27.
Hauser SL, Chan JR, Oksenberg JR. PMID: 23955638.
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PubMed Mentions:
86 Fields:
Translation:
HumansCells
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Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes. J Neurosci. 2013 May 08; 33(19):8454-62.
Mei F, Wang H, Liu S, Niu J, Wang L, He Y, Etxeberria A, Chan JR, Xiao L. PMID: 23658182; PMCID: PMC3865513.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers. Nat Protoc. 2013 Apr; 8(4):771-82.
Lee S, Chong SY, Tuck SJ, Corey JM, Chan JR. PMID: 23589937; PMCID: PMC5190508.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration. Neurosci Bull. 2013 Apr; 29(2):177-88.
Mei F, Christin Chong SY, Chan JR. PMID: 23516141; PMCID: PMC5190510.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013 Jan 17; 152(1-2):248-61.
Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR. PMID: 23332759; PMCID: PMC3553550.
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PubMed Mentions:
192 Fields:
Translation:
AnimalsCells
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Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development. Sci Signal. 2012 Sep 25; 5(243):ra69.
Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan JR, Tsujimoto G, Tanoue A. PMID: 23012656.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods. 2012 Sep; 9(9):917-22.
Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR. PMID: 22796663; PMCID: PMC3433633.
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PubMed Mentions:
178 Fields:
Translation:
AnimalsCells
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Neuroscience. Revitalizing remyelination--the answer is circulating. Science. 2012 Apr 13; 336(6078):161-2.
Redmond SA, Chan JR. PMID: 22499927.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1299-304.
Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR. PMID: 22160722; PMCID: PMC3268264.
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PubMed Mentions:
109 Fields:
Translation:
AnimalsCells
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Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012 Jan 06; 287(2):1600-8.
Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. PMID: 22128191; PMCID: PMC3256919.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination. J Neurosci. 2011 Feb 23; 31(8):3032-43.
Lewallen KA, Shen YA, De la Torre AR, Ng BK, Meijer D, Chan JR. PMID: 21414924; PMCID: PMC3758556.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011; 34:21-43.
Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH. PMID: 21692657.
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PubMed Mentions:
142 Fields:
Translation:
HumansAnimalsCells
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Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis. Nat Protoc. 2010 Aug; 5(8):1396-405.
Kim YE, Chen J, Langen R, Chan JR. PMID: 20671723; PMCID: PMC4340478.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Tapping into the glial reservoir: cells committed to remaining uncommitted. J Cell Biol. 2010 Feb 08; 188(3):305-12.
Chong SY, Chan JR. PMID: 20142420; PMCID: PMC2819683.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration. Nat Methods. 2010 Jan; 7(1):67-73.
Kim YE, Chen J, Chan JR, Langen R. PMID: 19966809; PMCID: PMC2846705.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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A collaboration conducive to conduction: matching axonal density to oligodendroglial number (Commentary on Kawai et al.). Eur J Neurosci. 2009 Dec 03; 30(11):2029.
Hahn AT, Chan JR. PMID: 20128841.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Modulating myelination: knowing when to say Wnt. Genes Dev. 2009 Jul 01; 23(13):1487-93.
Rosenberg SS, Chan JR. PMID: 19571178; PMCID: PMC4419287.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14662-7.
Rosenberg SS, Kelland EE, Tokar E, De la Torre AR, Chan JR. PMID: 18787118; PMCID: PMC2567234.
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PubMed Mentions:
114 Fields:
Translation:
AnimalsCells
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ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol. 2008 Apr 21; 181(2):351-65.
Yamauchi J, Miyamoto Y, Chan JR, Tanoue A. PMID: 18426980; PMCID: PMC2315680.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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Receiving mixed signals: uncoupling oligodendrocyte differentiation and myelination. Cell Mol Life Sci. 2007 Dec; 64(23):3059-68.
Rosenberg SS, Powell BL, Chan JR. PMID: 17876524.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. J Cell Sci. 2007 Dec 15; 120(Pt 24):4355-66.
Miyamoto Y, Yamauchi J, Chan JR, Okada A, Tomooka Y, Hisanaga S, Tanoue A. PMID: 18042622.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination. J Neurosci. 2007 Jul 11; 27(28):7597-603.
Ng BK, Chen L, Mandemakers W, Cosgaya JM, Chan JR. PMID: 17626221; PMCID: PMC6672611.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Myelination: all about Rac 'n' roll. J Cell Biol. 2007 Jun 18; 177(6):953-5.
Chan JR. PMID: 17576794; PMCID: PMC2064356.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J Neurosci. 2007 Jan 03; 27(1):220-5.
Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu M, Miller RH, Chan JR, Mi S. PMID: 17202489; PMCID: PMC6672289.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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The polarity protein Par-3 directly interacts with p75NTR to regulate myelination. Science. 2006 Nov 03; 314(5800):832-6.
Chan JR, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M. PMID: 17082460.
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PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
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The quest for remyelination: a new role for neurotrophins and their receptors. Brain Pathol. 2006 Oct; 16(4):288-94.
Rosenberg SS, Ng BK, Chan JR. PMID: 17107598; PMCID: PMC8095791.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14889-94.
Yamauchi J, Miyamoto Y, Tanoue A, Shooter EM, Chan JR. PMID: 16203995; PMCID: PMC1253593.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5198-203.
Yamauchi J, Chan JR, Miyamoto Y, Tsujimoto G, Shooter EM. PMID: 15758069; PMCID: PMC556009.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking. Mol Cell Neurosci. 2005 Mar; 28(3):571-87.
Saxena S, Howe CL, Cosgaya JM, Steiner P, Hirling H, Chan JR, Weis J, Krüttgen A. PMID: 15737746.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron. 2004 Jul 22; 43(2):183-91.
Chan JR, Watkins TA, Cosgaya JM, Zhang C, Chen L, Reichardt LF, Shooter EM, Barres BA. PMID: 15260955; PMCID: PMC2758239.
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PubMed Mentions:
148 Fields:
Translation:
AnimalsCells
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Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8774-9.
Yamauchi J, Chan JR, Shooter EM. PMID: 15161978; PMCID: PMC423271.
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PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
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Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 are sorted to dense-core vesicles and released via the regulated pathway in primary rat cortical neurons. J Neurosci Res. 2004 Mar 15; 75(6):825-34.
Wu YJ, Krüttgen A, Möller JC, Shine D, Chan JR, Shooter EM, Cosgaya JM. PMID: 14994343.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture. Mol Cell Neurosci. 2004 Feb; 25(2):241-51.
Ullian EM, Harris BT, Wu A, Chan JR, Barres BA. PMID: 15019941.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14421-6.
Yamauchi J, Chan JR, Shooter EM. PMID: 14614136; PMCID: PMC283607.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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The neurotrophin receptor p75NTR as a positive modulator of myelination. Science. 2002 Nov 08; 298(5596):1245-8.
Cosgaya JM, Chan JR, Shooter EM. PMID: 12424382.
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PubMed Mentions:
128 Fields:
Translation:
AnimalsCells
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Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14661-8.
Chan JR, Cosgaya JM, Wu YJ, Shooter EM. PMID: 11717413; PMCID: PMC64738.
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PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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Progesterone synthesized by Schwann cells during myelin formation regulates neuronal gene expression. Mol Biol Cell. 2000 Jul; 11(7):2283-95.
Chan JR, Rodriguez-Waitkus PM, Ng BK, Liang P, Glaser M. PMID: 10888668; PMCID: PMC14919.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10459-64.
Chan JR, Phillips LJ, Glaser M. PMID: 9724725; PMCID: PMC27916.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Measurement of the rate of myelination using a fluorescent analogue of ceramide. J Neurosci Res. 1997 Aug 15; 49(4):497-507.
Bilderback TR, Chan JR, Harvey JJ, Glaser M. PMID: 9285525.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells