Jonah Chan, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #216A
San Francisco CA 94158
ORCID ORCID Icon0000-0002-2176-1242 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

    Collapse Biography 
    Collapse Education and Training
    University of Illinois Urbana-ChampaignBSBiochemistry
    University of Illinois Urbana-ChampaignPhDNeuroscience
    Stanford UniversityPostdocNeurobiology
    Collapse Awards and Honors
    The McKnight Foundation2020McKnight Memory and Cognitive Disorders Award
    NIH/NINDS2019Landis Award for Outstanding Mentorship
    National MS Society2013Barancik Prize for Innovation in MS Research
    UCSF2010Debbie and Andy Rachleff Distinguished Professor of Neurology
    National MS Society2009Harry Weaver Neuroscience Award
    Baxter Foundation2006 The Donald E. and Delia B. Baxter Foundation Scholar
    National MS Society2004NMSS Career Transition Award
    NIH/NINDS2002NIH F32 Postdoctoral Fellowship
    Stanford University2000NIH Neurobiology Postdoctoral Training Fellowship
    University of Illinois, Urbana-Champaign1994Sidebottom Award for Most Outstanding Honors Thesis in Biochemistry
    University of Illinois, Urbana-Champaign1993Monsanto Biotechnology Research Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Jonah R. Chan received his BS in Biochemistry and PhD in Neuroscience at the University of Illinois at Urbana-Champaign. He completed a postdoctoral fellowship in the Department of Neurobiology at Stanford University with Dr. Eric Shooter. Jonah is currently the Debbie and Andy Rachleff Distinguished Professor of Neurology. He is a member of the Neuroscience Graduate Program, Vice Chief in the Division of Neuroimmunology and Glial Biology and Co-Director of the Innovation Program for Remyelination and Repair at UCSF.

    The Chan laboratory has a long-standing interest in fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Myelination is one of the most exquisite examples of cell-cell interaction found in nature and functions to maximize the efficiency and velocity of action potentials transmitted throughout the nervous system. While much has been learned about the global determinants that generate myelin-forming cells during development, the Chan laboratory is particularly interested in understanding how local environmental cues control the spatiotemporal regulation of differentiation and myelination, including both molecular and biophysical interactions. Identification of an environment that is conducive for myelination could have important implications for efforts aimed at promoting repair and remyelination in the nervous system.

    Current Laboratory Members:

    Trung Huynh, BS
    Lab Manager

    Sarah Raissi, PhD
    Postdoctoral Fellow

    Wendy Xin, PhD
    Postdoctoral Fellow

    Monique Lillis, BS
    Graduate Student

    Albert Zhang, PhD
    Postdoctoral Fellow

    Sonia Nocera, PhD
    Postdoctoral Fellow

    Lahin Lalani, BS
    Graduate Student

    Irvin Bhangal, BA
    Assistant Specialist

    Nora Jabassini, BS
    Assistant Specialist

    Collapse Research 
    Collapse Research Activities and Funding
    Identification of regulatory mechanisms operating in rare pathogenic astrocyte subsets in multiple sclerosis with a novel genomic technology
    NIH R01NS130876Aug 1, 2023 - Jul 31, 2028
    Role: Co-Principal Investigator
    Cell-type, circuit and network mechanisms of adult oligodendrogenesis in memory storage and retrieval
    NIH R01MH125515Jul 2, 2021 - Apr 30, 2026
    Role: Co-Principal Investigator
    Neuropeptides as axonal determinants for oligodendrocyte differentiation and myelination
    NIH R01NS115746Dec 1, 2020 - Nov 30, 2025
    Role: Principal Investigator
    Functional Screening of GPCR Small Molecule Libraries for Remyelination Therapies
    NIH R01NS095889Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Somatodendritic Inhibition of Oligodendrocyte Myelination
    NIH R01NS097428Jun 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    The establishment of Schwann cell polarity and the initiation of myelination
    NIH R01NS062796Jul 15, 2008 - Apr 30, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Acute and Chronic Demyelination Independent of Inflammation Promotes Tissue- and Blood-markers of Neuroaxonal Pathology (S17.010). Neurology. 2024 Apr 9; 102(17_supplement_1). Abdelhak AA, Cordano CC, Emberley EK, Duncan DG, Nocera NS, Ananth AK, Jabassini JN, Ning NK, Reinsberg RH, Oertel OF, Beaudry-Richard BA, Kuhle KJ, Watkins WT, Chan CJ, Emery EB, Green GA. .
      View in: Publisher Site   Mentions:
    2. Synaptic Injury in the IPL of the Retina Is a Predictor of Progression in Multiple Sclerosis (P6-6.003). Neurology. 2024 Apr 9; 102(17_supplement_1). Cordano CC, Werneburg WS, Abdelhak AA, Bennett BD, Beaudry-richard BA, Duncan DG, Oertel OF, Boscardin BJ, Yiu YH, Jabassini JN, Merritt ML, Nocera NS, Sin SJ, Montes MS, Ananth AK, Bischof BA, Nourbakhsh NB, Hauser HS, Cree CB, Emery EB, Chan CJ, Schafer SD, Green GA. .
      View in: Publisher Site   Mentions:
    3. Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis. Cell Rep Med. 2024 Mar 26; 101490. Cordano C, Werneburg S, Abdelhak A, Bennett DJ, Beaudry-Richard A, Duncan GJ, Oertel FC, Boscardin WJ, Yiu HH, Jabassini N, Merritt L, Nocera S, Sin JH, Samana IP, Condor Montes SY, Ananth K, Bischof A, UCSF MS EPIC Team, Nourbakhsh B, Hauser SL, Cree BAC, Emery B, Schafer DP, Chan JR, Green AJ. PMID: 38574736.
      View in: PubMed   Mentions:    Fields:    
    4. Minimum Effective Dose of Clemastine in a Mouse Model of Preterm White Matter Injury. bioRxiv. 2024 Mar 01. Odell E, Jabassini N, Schniedewind B, Pease-Raissi SE, Frymoyer A, Christians U, Green AJ, Chan JR, Ostrem BEL. PMID: 38464078; PMCID: PMC10925142.
      View in: PubMed   Mentions:
    5. Identification and In Vivo Evaluation of Myelination Agent PIPE-3297, a Selective Kappa Opioid Receptor Agonist Devoid of β-Arrestin-2 Recruitment Efficacy. ACS Chem Neurosci. 2024 Feb 07; 15(3):685-698. Schrader TO, Lorrain KI, Bagnol D, Edu GC, Broadhead A, Baccei C, Poon MM, Stebbins KJ, Xiong Y, Lorenzana AO, Chan JR, Green AJ, Lorrain DS, Chen A. PMID: 38265210.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex. bioRxiv. 2023 Sep 30. Xin W, Kaneko M, Roth RH, Zhang A, Nocera S, Ding JB, Stryker MP, Chan JR. PMID: 37808666; PMCID: PMC10557765.
      View in: PubMed   Mentions: 1  
    7. Remyelination by preexisting oligodendrocytes: Glass half full or half empty? Neuron. 2023 06 07; 111(11):1689-1691. Nocera S, Chan JR. PMID: 37290399.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response. Glia. 2023 09; 71(9):2180-2195. Chen Y, Quan S, Patil V, Kunjamma RB, Tokars HM, Leisten ED, Joy G, Wills S, Chan JR, Wong YC, Popko B. PMID: 37203250; PMCID: PMC10681276.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial. Proc Natl Acad Sci U S A. 2023 05 16; 120(20):e2217635120. Caverzasi E, Papinutto N, Cordano C, Kirkish G, Gundel TJ, Zhu A, Akula AV, Boscardin WJ, Neeb H, Henry RG, Chan JR, Green AJ. PMID: 37155847; PMCID: PMC10193980.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy. Brain. 2022 11 21; 145(11):3943-3952. Cordano C, Sin JH, Timmons G, Yiu HH, Stebbins K, Guglielmetti C, Cruz-Herranz A, Xin W, Lorrain D, Chan JR, Green AJ. PMID: 35678509; PMCID: PMC10200282.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    11. Motor learning revamps the myelin landscape. Nat Neurosci. 2022 10; 25(10):1251-1252. Xin W, Chan JR. PMID: 36180789; PMCID: PMC10668869.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    12. Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2022 Jun 16. Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, Chan JR, Green AJ. PMID: 35710320; PMCID: PMC9984688.
      View in: PubMed   Mentions: 3     Fields:    
    13. A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial. Mult Scler Relat Disord. 2022 May; 61:103747. Bove R, Anderson A, Rowles W, Rankin KA, Hills NK, Carleton M, Cooper J, Cree BAC, Gelfand JM, Graves JS, Henry RG, Krysko KM, Rush G, Zamvil SS, Joffe H, Chan JR, Green AJ. PMID: 35397292.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    14. Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin. Neuron. 2021 11 17; 109(22):3619-3632.e5. Osso LA, Rankin KA, Chan JR. PMID: 34536353; PMCID: PMC8602781.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    15. Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells. J Neurosci. 2021 10 20; 41(42):8710-8724. Follis RM, Tep C, Genaro-Mattos TC, Kim ML, Ryu JC, Morrison VE, Chan JR, Porter N, Carter BD, Yoon SO. PMID: 34507952; PMCID: PMC8528492.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Clinical Applications of Myelin Plasticity for Remyelinating Therapies in Multiple Sclerosis. Ann Neurol. 2021 10; 90(4):558-567. Pan S, Chan JR. PMID: 34402546; PMCID: PMC8555870.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation. Neuron. 2021 10 06; 109(19):3104-3118.e6. Niu J, Yu G, Wang X, Xia W, Wang Y, Hoi KK, Mei F, Xiao L, Chan JR, Fancy SPJ. PMID: 34390652; PMCID: PMC8547708.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease. Neuron. 2021 07 21; 109(14):2292-2307.e5. Chen JF, Liu K, Hu B, Li RR, Xin W, Chen H, Wang F, Chen L, Li RX, Ren SY, Xiao L, Chan JR, Mei F. PMID: 34102111; PMCID: PMC8298291.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    19. Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment. Elife. 2021 03 23; 10. Chen Y, Kunjamma RB, Weiner M, Chan JR, Popko B. PMID: 33752802; PMCID: PMC7987340.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    20. TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells. Elife. 2021 03 10; 10. Chang KJ, Agrawal I, Vainshtein A, Ho WY, Xin W, Tucker-Kellogg G, Susuki K, Peles E, Ling SC, Chan JR. PMID: 33689679; PMCID: PMC7946431.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination. Neuron. 2021 04 21; 109(8):1258-1273. Pease-Raissi SE, Chan JR. PMID: 33621477; PMCID: PMC8068592.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. Myelin plasticity: sculpting circuits in learning and memory. Nat Rev Neurosci. 2020 12; 21(12):682-694. Xin W, Chan JR. PMID: 33046886; PMCID: PMC8018611.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    23. Preservation of a remote fear memory requires new myelin formation. Nat Neurosci. 2020 04; 23(4):487-499. Pan S, Mayoral SR, Choi HS, Chan JR, Kheirbek MA. PMID: 32042175; PMCID: PMC7213814.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    24. Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory. Nat Neurosci. 2020 04; 23(4):481-486. Wang F, Ren SY, Chen JF, Liu K, Li RX, Li ZF, Hu B, Niu JQ, Xiao L, Chan JR, Mei F. PMID: 32042174; PMCID: PMC7306053.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    25. That Wasn't a Complement-Too Much C3 in Demyelinating Disease. Immunity. 2020 01 14; 52(1):11-13. Xin W, Chan JR. PMID: 31951547; PMCID: PMC8057118.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7. Nat Commun. 2019 07 05; 10(1):2976. Harty BL, Coelho F, Pease-Raissi SE, Mogha A, Ackerman SD, Herbert AL, Gereau RW, Golden JP, Lyons DA, Chan JR, Monk KR. PMID: 31278268; PMCID: PMC6611888.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    27. A surprising role for myelin in Williams syndrome. Nat Neurosci. 2019 05; 22(5):681-683. Osso LA, Chan JR. PMID: 31011225.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    28. Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Nat Neurosci. 2019 05; 22(5):709-718. Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ. PMID: 30988524; PMCID: PMC6486410.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    29. Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors. J Neurosci. 2019 03 20; 39(12):2184-2194. Rankin KA, Mei F, Kim K, Shen YA, Mayoral SR, Desponts C, Lorrain DS, Green AJ, Baranzini SE, Chan JR, Bove R. PMID: 30696729; PMCID: PMC6433770.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    30. Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber. Cell Rep. 2018 10 16; 25(3):544-550.e3. Mayoral SR, Etxeberria A, Shen YA, Chan JR. PMID: 30332636; PMCID: PMC6258034.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    31. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia. Neuron. 2018 08 22; 99(4):689-701.e5. Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ, Xiao L, Chan JR, Mei F. PMID: 30078577; PMCID: PMC6170028.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    32. The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner. Glia. 2018 09; 66(9):1947-1959. Jiang M, Rao R, Wang J, Wang J, Xu L, Wu LM, Chan JR, Wang H, Lu QR. PMID: 29722913; PMCID: PMC6185760.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand. Curr Biol. 2018 04 23; 28(8):1296-1305.e5. Almeida RG, Pan S, Cole KLH, Williamson JM, Early JJ, Czopka T, Klingseisen A, Chan JR, Lyons DA. PMID: 29628374; PMCID: PMC5912901.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    34. Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury. Brain. 2018 01 01; 141(1):85-98. Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ. PMID: 29244098; PMCID: PMC6394402.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    35. Micro(glial)-managing executive function: white matter inflammation drives catatonia. J Clin Invest. 2018 02 01; 128(2):564-566. Pease-Raissi SE, Chan JR. PMID: 29252213; PMCID: PMC5785255.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    36. Regulation and dysregulation of axon infrastructure by myelinating glia. J Cell Biol. 2017 12 04; 216(12):3903-3916. Pan S, Chan JR. PMID: 29114067; PMCID: PMC5716274.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    37. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804; PMCID: PMC5851281.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    38. Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial. Lancet. 2017 Dec 02; 390(10111):2481-2489. Green AJ, Gelfand JM, Cree BA, Bevan C, Boscardin WJ, Mei F, Inman J, Arnow S, Devereux M, Abounasr A, Nobuta H, Zhu A, Friessen M, Gerona R, von Büdingen HC, Henry RG, Hauser SL, Chan JR. PMID: 29029896.
      View in: PubMed   Mentions: 184     Fields:    Translation:Humans
    39. Mechanical plasticity during oligodendrocyte differentiation and myelination. Glia. 2018 01; 66(1):5-14. Domingues HS, Cruz A, Chan JR, Relvas JB, Rubinstein B, Pinto IM. PMID: 28940651; PMCID: PMC5743057.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    40. Architecting the myelin landscape. Curr Opin Neurobiol. 2017 12; 47:1-7. Osso LA, Chan JR. PMID: 28709021; PMCID: PMC5732869.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    41. A high-throughput screen identifies a candidate molecule that promotes remyelination with significant translational potential (S50.003). Neurology. 2017 Apr 18; 88(16_supplement). Rankin RK, Shen SY, Mei MF, Desponts DC, Lorrain LD, Green GA, Chan CJ, Bove BR. .
      View in: Publisher Site   Mentions:
    42. Regulatory T cells promote myelin regeneration in the central nervous system. Nat Neurosci. 2017 May; 20(5):674-680. Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC. PMID: 28288125; PMCID: PMC5409501.
      View in: PubMed   Mentions: 190     Fields:    Translation:AnimalsCells
    43. Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. Elife. 2016 Sep 27; 5. Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. PMID: 27671734; PMCID: PMC5039026.
      View in: PubMed   Mentions: 126     Fields:    
    44. Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Neuron. 2016 Aug 17; 91(4):824-836. Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E, Chan JR. PMID: 27499083; PMCID: PMC4990461.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    45. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. PMID: 27466337; PMCID: PMC4961778.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    46. Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity. J Neurosci. 2016 06 29; 36(26):6937-48. Etxeberria A, Hokanson KC, Dao DQ, Mayoral SR, Mei F, Redmond SA, Ullian EM, Chan JR. PMID: 27358452; PMCID: PMC4926240.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    47. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. 2016 07 06; 91(1):41-55. Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ. PMID: 27321923; PMCID: PMC4938715.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    48. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat Neurosci. 2016 08; 19(8):1060-72. Wu LM, Wang J, Conidi A, Zhao C, Wang H, Ford Z, Zhang L, Zweier C, Ayee BG, Maurel P, Zwijsen A, Chan JR, Jankowski MP, Huylebroeck D, Lu QR. PMID: 27294509; PMCID: PMC4961522.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    49. The environment rules: spatiotemporal regulation of oligodendrocyte differentiation. Curr Opin Neurobiol. 2016 08; 39:47-52. Mayoral SR, Chan JR. PMID: 27128881; PMCID: PMC4987220.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    50. Remodeling myelination: implications for mechanisms of neural plasticity. Nat Neurosci. 2016 Feb; 19(2):190-7. Chang KJ, Redmond SA, Chan JR. PMID: 26814588; PMCID: PMC4792270.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    51. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016 Jan 22; 351(6271):379-84. Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP. PMID: 26798014; PMCID: PMC5472053.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimalsCells
    52. Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. J Neurosci. 2016 Jan 20; 36(3):806-13. Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, Casaccia P. PMID: 26791211; PMCID: PMC4719016.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    53. Astrocytes Underlie Neuroinflammatory Memory Impairment. Cell. 2015 Dec 17; 163(7):1574-6. Osso LA, Chan JR. PMID: 26687350; PMCID: PMC4786168.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    54. Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor. Biotechnol J. 2016 Mar; 11(3):425-36. Burns ML, Malott TM, Metcalf KJ, Puguh A, Chan JR, Shusta EV. PMID: 26580314.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    55. The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry. J Cell Biol. 2015 Sep 14; 210(6):891-8. von Büdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan JR. PMID: 26347141; PMCID: PMC4576870.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    56. Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent. Nat Commun. 2014 Sep 26; 5:4991. Shen YA, Chen Y, Dao DQ, Mayoral SR, Wu L, Meijer D, Ullian EM, Chan JR, Lu QR. PMID: 25255972; PMCID: PMC4334370.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    57. Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae. Appl Environ Microbiol. 2014 Sep; 80(18):5732-42. Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan JR, Shusta EV. PMID: 25015885; PMCID: PMC4178591.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    58. Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat Med. 2014 Aug; 20(8):954-960. Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJM, Green A, Hauser SL, Chan JR. PMID: 24997607; PMCID: PMC4830134.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    59. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. PMID: 24776795; PMCID: PMC4057936.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    60. Multiple sclerosis: Prospects and promise. Ann Neurol. 2013 Sep; 74(3):317-27. Hauser SL, Chan JR, Oksenberg JR. PMID: 23955638.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    61. Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes. J Neurosci. 2013 May 08; 33(19):8454-62. Mei F, Wang H, Liu S, Niu J, Wang L, He Y, Etxeberria A, Chan JR, Xiao L. PMID: 23658182; PMCID: PMC3865513.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    62. A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers. Nat Protoc. 2013 Apr; 8(4):771-82. Lee S, Chong SY, Tuck SJ, Corey JM, Chan JR. PMID: 23589937; PMCID: PMC5190508.
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    63. Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration. Neurosci Bull. 2013 Apr; 29(2):177-88. Mei F, Christin Chong SY, Chan JR. PMID: 23516141; PMCID: PMC5190510.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    64. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013 Jan 17; 152(1-2):248-61. Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR. PMID: 23332759; PMCID: PMC3553550.
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    65. Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development. Sci Signal. 2012 Sep 25; 5(243):ra69. Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan JR, Tsujimoto G, Tanoue A. PMID: 23012656.
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    66. A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods. 2012 Sep; 9(9):917-22. Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR. PMID: 22796663; PMCID: PMC3433633.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    67. Neuroscience. Revitalizing remyelination--the answer is circulating. Science. 2012 Apr 13; 336(6078):161-2. Redmond SA, Chan JR. PMID: 22499927.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    68. Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1299-304. Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR. PMID: 22160722; PMCID: PMC3268264.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    69. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012 Jan 06; 287(2):1600-8. Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. PMID: 22128191; PMCID: PMC3256919.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    70. Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination. J Neurosci. 2011 Feb 23; 31(8):3032-43. Lewallen KA, Shen YA, De la Torre AR, Ng BK, Meijer D, Chan JR. PMID: 21414924; PMCID: PMC3758556.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    71. Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011; 34:21-43. Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH. PMID: 21692657.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    72. Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis. Nat Protoc. 2010 Aug; 5(8):1396-405. Kim YE, Chen J, Langen R, Chan JR. PMID: 20671723; PMCID: PMC4340478.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    73. Tapping into the glial reservoir: cells committed to remaining uncommitted. J Cell Biol. 2010 Feb 08; 188(3):305-12. Chong SY, Chan JR. PMID: 20142420; PMCID: PMC2819683.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    74. Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration. Nat Methods. 2010 Jan; 7(1):67-73. Kim YE, Chen J, Chan JR, Langen R. PMID: 19966809; PMCID: PMC2846705.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    75. A collaboration conducive to conduction: matching axonal density to oligodendroglial number (Commentary on Kawai et al.). Eur J Neurosci. 2009 Dec 03; 30(11):2029. Hahn AT, Chan JR. PMID: 20128841.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    76. Modulating myelination: knowing when to say Wnt. Genes Dev. 2009 Jul 01; 23(13):1487-93. Rosenberg SS, Chan JR. PMID: 19571178; PMCID: PMC4419287.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    77. The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14662-7. Rosenberg SS, Kelland EE, Tokar E, De la Torre AR, Chan JR. PMID: 18787118; PMCID: PMC2567234.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    78. ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol. 2008 Apr 21; 181(2):351-65. Yamauchi J, Miyamoto Y, Chan JR, Tanoue A. PMID: 18426980; PMCID: PMC2315680.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    79. Receiving mixed signals: uncoupling oligodendrocyte differentiation and myelination. Cell Mol Life Sci. 2007 Dec; 64(23):3059-68. Rosenberg SS, Powell BL, Chan JR. PMID: 17876524.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    80. Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. J Cell Sci. 2007 Dec 15; 120(Pt 24):4355-66. Miyamoto Y, Yamauchi J, Chan JR, Okada A, Tomooka Y, Hisanaga S, Tanoue A. PMID: 18042622.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    81. Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination. J Neurosci. 2007 Jul 11; 27(28):7597-603. Ng BK, Chen L, Mandemakers W, Cosgaya JM, Chan JR. PMID: 17626221; PMCID: PMC6672611.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    82. Myelination: all about Rac 'n' roll. J Cell Biol. 2007 Jun 18; 177(6):953-5. Chan JR. PMID: 17576794; PMCID: PMC2064356.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    83. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J Neurosci. 2007 Jan 03; 27(1):220-5. Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu M, Miller RH, Chan JR, Mi S. PMID: 17202489; PMCID: PMC6672289.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    84. The polarity protein Par-3 directly interacts with p75NTR to regulate myelination. Science. 2006 Nov 03; 314(5800):832-6. Chan JR, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M. PMID: 17082460.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    85. The quest for remyelination: a new role for neurotrophins and their receptors. Brain Pathol. 2006 Oct; 16(4):288-94. Rosenberg SS, Ng BK, Chan JR. PMID: 17107598; PMCID: PMC8095791.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    86. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14889-94. Yamauchi J, Miyamoto Y, Tanoue A, Shooter EM, Chan JR. PMID: 16203995; PMCID: PMC1253593.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    87. The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5198-203. Yamauchi J, Chan JR, Miyamoto Y, Tsujimoto G, Shooter EM. PMID: 15758069; PMCID: PMC556009.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    88. Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking. Mol Cell Neurosci. 2005 Mar; 28(3):571-87. Saxena S, Howe CL, Cosgaya JM, Steiner P, Hirling H, Chan JR, Weis J, Krüttgen A. PMID: 15737746.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    89. NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron. 2004 Jul 22; 43(2):183-91. Chan JR, Watkins TA, Cosgaya JM, Zhang C, Chen L, Reichardt LF, Shooter EM, Barres BA. PMID: 15260955; PMCID: PMC2758239.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    90. Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8774-9. Yamauchi J, Chan JR, Shooter EM. PMID: 15161978; PMCID: PMC423271.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    91. Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 are sorted to dense-core vesicles and released via the regulated pathway in primary rat cortical neurons. J Neurosci Res. 2004 Mar 15; 75(6):825-34. Wu YJ, Krüttgen A, Möller JC, Shine D, Chan JR, Shooter EM, Cosgaya JM. PMID: 14994343.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    92. Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture. Mol Cell Neurosci. 2004 Feb; 25(2):241-51. Ullian EM, Harris BT, Wu A, Chan JR, Barres BA. PMID: 15019941.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    93. Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14421-6. Yamauchi J, Chan JR, Shooter EM. PMID: 14614136; PMCID: PMC283607.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    94. The neurotrophin receptor p75NTR as a positive modulator of myelination. Science. 2002 Nov 08; 298(5596):1245-8. Cosgaya JM, Chan JR, Shooter EM. PMID: 12424382.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    95. Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14661-8. Chan JR, Cosgaya JM, Wu YJ, Shooter EM. PMID: 11717413; PMCID: PMC64738.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    96. Progesterone synthesized by Schwann cells during myelin formation regulates neuronal gene expression. Mol Biol Cell. 2000 Jul; 11(7):2283-95. Chan JR, Rodriguez-Waitkus PM, Ng BK, Liang P, Glaser M. PMID: 10888668; PMCID: PMC14919.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    97. Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10459-64. Chan JR, Phillips LJ, Glaser M. PMID: 9724725; PMCID: PMC27916.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    98. Measurement of the rate of myelination using a fluorescent analogue of ceramide. J Neurosci Res. 1997 Aug 15; 49(4):497-507. Bilderback TR, Chan JR, Harvey JJ, Glaser M. PMID: 9285525.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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