Aparna Lakkaraju, PhD
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Title(s) | Associate Professor, Ophthalmology |
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School | School of Medicine |
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Address | 10 Koret Way San Francisco CA 94117
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Phone | 415-502-9670 |
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vCard | Download vCard |
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Biography University of Minnesota, Minneapolis | PhD | | Pharmaceutical Sciences | Cornell University Weill Medical College, New York | Post-doctoral Training | | Ophthalmology & Cell Biology |
Research to Prevent Blindness Foundation | 2019
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| 2022 | Catalyst Award for Innovative Approaches to Age-Related Macular Degeneration | BrightFocus Foundation | 2015
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| 2018 | Charlotte & Alexander Danilevsky Award for Macular Degeneration Research | Wisconsin Partnership Program | 2015
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| 2017 | New Investigator Award | Retina Research Foundation | 2012
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| 2018 | Rebecca Meyer Brown Professorship | Research to Prevent Blindness | 2010
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| 2014 | Career Development Award | National Eye Institute | 2003
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| 2006 | Ruth L. Kirchstein F32 Individual Post-Doctoral Fellowship Award |
Overview Research in the Lakkaraju laboratory builds on fundamental insights from retinal cell biology to develop effective therapies for inherited and age-related macular degenerations (AMD). These diseases destroy central high-resolution vision in over 30 million people globally and have limited therapeutic options. We study the retinal pigment epithelium (RPE), which performs numerous functions indispensable for vision, and is a key site of injury in macular degenerations. Current areas of research focus include: 1. Autophagy and extracellular vesicles in the RPE; 2.Mitochondrial dynamics, metabolic stress and inflammation in the retina; 3. The role of complement activation in AMD; 4. Biophysical approaches to understanding the genetic basis of AMD; and 5. Novel drug targets for macular degenerations. Using advanced live imaging of the RPE and retina, we recently identified promising FDA-approved drugs that can be repositioned to treat macular degenerations (U.S. Patent P140282US01).
Research ORNG Applications Bibliographic
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Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration. Redox Biol. 2020 Nov 02; 101781.
Tan LX, Germer CJ, La Cunza N, Lakkaraju A. PMID: 33162377.
View in: PubMed Mentions: Fields:
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The cell biology of the retinal pigment epithelium. Prog Retin Eye Res. 2020 Feb 24; 100846.
Lakkaraju A, Umapathy A, Tan LX, Daniele L, Philp NJ, Boesze-Battaglia K, Williams DS. PMID: 32105772.
View in: PubMed Mentions: 6 Fields:
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Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition. Mol Cancer Res. 2020 01; 18(1):33-45.
Denu RA, Kaur G, Sass MM, Lakkaraju A, Burkard ME. PMID: 31604847.
View in: PubMed Mentions: Fields: Translation: HumansCells
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A NOVEL ROLE FOR THE FTD-CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING. Alzheimer's & Dementia. 2019 Jul 1; 15(7):p1509.
Claire Clelland, J. Iker Etchegaray, Lay Kodama, Faten Sayed, Aradhana Sachdev, Yaqiao Li, David Le, Lihong Zhan, Yungui Zhou, Duc Duong, Nicholas T. Seyfried, Thomas G. Kukar, Li Xuan Tan, Aparna Lakkaraju, Bruce Conklin, Li Gan. .
View in: Publisher Site Mentions:
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“Use of Inhibitors of Acid Sphingomyelinase to Treat Acquired and Inherited Retinal Degenerations”. 2018.
Lakkaraju A, ToopsKA, Tan LX.
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Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):9014-9019.
Kaur G, Tan LX, Rathnasamy G, La Cunza N, Germer CJ, Toops KA, Fernandes M, Blenkinsop TA, Lakkaraju A. PMID: 30126999.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Early Endosome Morphology in Health and Disease. Adv Exp Med Biol. 2018; 1074:335-343.
Kaur G, Lakkaraju A. PMID: 29721961.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Drusen Ooze: A Novel Hypothesis in Geographic Atrophy. Ophthalmol Retina. 2017 Nov - Dec; 1(6):461-473.
Monés J, Garcia M, Biarnés M, Lakkaraju A, Ferraro L. PMID: 31047436.
View in: PubMed Mentions: 1 Fields:
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Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. Mol Vis. 2017; 23:60-89.
Samuel W, Jaworski C, Postnikova OA, Kutty RK, Duncan T, Tan LX, Poliakov E, Lakkaraju A, Redmond TM. PMID: 28356702.
View in: PubMed Mentions: 29 Fields: Translation: HumansCells
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Novel roles for the radial spoke head protein 9 in neural and neurosensory cilia. Sci Rep. 2016 Sep 30; 6:34437.
Sedykh I, TeSlaa JJ, Tatarsky RL, Keller AN, Toops KA, Lakkaraju A, Nyholm MK, Wolman MA, Grinblat Y. PMID: 27687975.
View in: PubMed Mentions: 5 Fields:
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Protective responses to sublytic complement in the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8789-94.
Tan LX, Toops KA, Lakkaraju A. PMID: 27432952.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Apolipoprotein E Isoforms and AMD. Adv Exp Med Biol. 2016; 854:3-9.
Toops KA, Tan LX, Lakkaraju A. PMID: 26427386.
View in: PubMed Mentions: 12 Fields: Translation: HumansCells
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Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Mol Biol Cell. 2015 Jan 01; 26(1):1-14.
Toops KA, Tan LX, Jiang Z, Radu RA, Lakkaraju A. PMID: 25378587.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
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A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers. Exp Eye Res. 2014 Jul; 124:74-85.
PMID: 24861273.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells. Mol Vis. 2014; 20:285-300.
PMID: 24644403.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Should I stay or should I go? Trafficking of sub-lytic MAC in the retinal pigment epithelium. Adv Exp Med Biol. 2014; 801:267-74.
Lakkaraju A, Toops KA, Xu J. PMID: 24664707.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Mechanism of polarized lysosome exocytosis in epithelial cells. Journal of Cell Science. 2013 Nov 1; 126(21):5086-5086.
Jin Xu, Kimberly A. Toops, Fernando Diaz, Jose Maria Carvajal-Gonzalez, Diego Gravotta, Francesca Mazzoni, Ryan Schreiner, Enrique Rodriguez-Boulan, Aparna Lakkaraju. .
View in: Publisher Site Mentions:
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Let's play a game of chutes and ladders: Lysosome fusion with the epithelial plasma membrane. Commun Integr Biol. 2013 Jul 01; 6(4):e24474.
PMID: 23986802.
View in: PubMed Mentions:
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Mechanism of polarized lysosome exocytosis in epithelial cells. J Cell Sci. 2012 Dec 15; 125(Pt 24):5937-43.
PMID: 23038769.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
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Endo-lysosome function in the retinal pigment epithelium in health and disease. Adv Exp Med Biol. 2012; 723:723-9.
PMID: 22183399.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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It takes two to tango to the melanosome. J Cell Biol. 2009 Oct 19; 187(2):161-3.
Lakkaraju A, Carvajal-Gonzalez JM, Rodriguez-Boulan E. PMID: 19841135.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8416-21.
Thorne RG, Lakkaraju A, Rodriguez-Boulan E, Nicholson C. PMID: 18541909.
View in: PubMed Mentions: 40 Fields: Translation: HumansAnimalsCells
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Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol. 2008 May; 18(5):199-209.
Lakkaraju A, Rodriguez-Boulan E. PMID: 18396047.
View in: PubMed Mentions: 146 Fields: Translation: HumansAnimalsCells
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Golgi apparatus and epithelial cell polarity. The Golgi Apparatus. 2008 Jan 1; 563-579.
Sylvie Deborde, Diego Gravotta, Aparna Lakkaraju, Enrique Rodriguez-Boulan. .
View in: Publisher Site Mentions:
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Cell biology: caught in the traffic. Nature. 2007 Jul 19; 448(7151):266-7.
Lakkaraju A, Rodriguez-Boulan E. PMID: 17637651.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):11026-31.
Lakkaraju A, Finnemann SC, Rodriguez-Boulan E. PMID: 17578916.
View in: PubMed Mentions: 61 Fields: Translation: HumansCells
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Epithelial Cells. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. 2006 Jan 1; 516-523.
Aparna Lakkaraju, Enrique Rodriguez-Boulan. .
View in: Publisher Site Mentions:
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Evolving endosomes: how many varieties and why? Curr Opin Cell Biol. 2005 Aug; 17(4):423-34.
Perret E, Lakkaraju A, Deborde S, Schreiner R, Rodriguez-Boulan E. PMID: 15975780.
View in: PubMed Mentions: 53 Fields: Translation: AnimalsCells
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Low-density lipoprotein receptor-related protein mediates the endocytosis of anionic liposomes in neurons. J Biol Chem. 2002 Apr 26; 277(17):15085-92.
Lakkaraju A, Rahman YE, Dubinsky JM. PMID: 11830589.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J Biol Chem. 2001 Aug 24; 276(34):32000-7.
Lakkaraju A, Dubinsky JM, Low WC, Rahman YE. PMID: 11406618.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Year | Publications |
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2001 | 1 | 2002 | 1 | 2005 | 1 | 2006 | 1 | 2007 | 2 | 2008 | 3 | 2009 | 1 | 2012 | 2 | 2013 | 2 | 2014 | 4 | 2016 | 3 | 2017 | 2 | 2018 | 3 | 2019 | 2 | 2020 | 2 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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