Anat Levit * UCSF Profiles

Anat Levit, PhD

Title(s)	Associate Specialist, Pharmaceutical Chemistry
School	School of Pharmacy
Phone	415-514-4253
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

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Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J. Structural identification of a hotspot on CFTR for potentiation. Science. 2019 06 21; 364(6446):1184-1188. PMID: 31221859.

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Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ. Ultra-large library docking for discovering new chemotypes. Nature. 2019 Feb; 566(7743):224-229. PMID: 30728502.

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Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY. Corrigendum: Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes. Front Mol Biosci. 2018; 5:84. PMID: 30255025.

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Pottel J, Levit A, Korczynska M, Fischer M, Shoichet BK. The Recognition of Unrelated Ligands by Identical Proteins. ACS Chem Biol. 2018 09 21; 13(9):2522-2533. PMID: 30095890.

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Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M. Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14. Biochim Biophys Acta Gen Subj. 2018 10; 1862(10):2162-2173. PMID: 30009876.

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Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY. Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes. Front Mol Biosci. 2018; 5:9. PMID: 29552563.

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Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL. Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. Nature. 2018 03 08; 555(7695):269-273. PMID: 29466326.

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Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 10 20; 358(6361):381-386. PMID: 29051383.

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Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell. 2017 01 26; 168(3):377-389.e12. PMID: 28129538.

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Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 09 08; 537(7619):185-190. PMID: 27533032.

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Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY. Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios. Methods Cell Biol. 2016; 132:401-27. PMID: 26928553.

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Levit A, Beuming T, Krilov G, Sherman W, Niv MY. Predicting GPCR promiscuity using binding site features. J Chem Inf Model. 2014 Jan 27; 54(1):184-94. PMID: 24328091.

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Levit A, Nowak S, Peters M, Wiener A, Meyerhof W, Behrens M, Niv MY. The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. FASEB J. 2014 Mar; 28(3):1181-97. PMID: 24285091.

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Born S, Levit A, Niv MY, Meyerhof W, Behrens M. The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J Neurosci. 2013 Jan 02; 33(1):201-13. PMID: 23283334.

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Chapnik N, Levit A, Niv MY, Froy O. Expression and structure/function relationships of human defensin 5. Appl Biochem Biotechnol. 2012 Apr; 166(7):1703-10. PMID: 22354633.

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Levit A, Barak D, Behrens M, Meyerhof W, Niv MY. Homology model-assisted elucidation of binding sites in GPCRs. Methods Mol Biol. 2012; 914:179-205. PMID: 22976029.

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Levit A, Yarnitzky T, Wiener A, Meidan R, Niv MY. Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs. PLoS One. 2011; 6(11):e27990. PMID: 22132188.

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Wiener A, Shudler M, Levit A, Niv MY. BitterDB: a database of bitter compounds. Nucleic Acids Res. 2012 Jan; 40(Database issue):D413-9. PMID: 21940398; PMCID: PMC3245057.

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Yarnitzky T, Levit A, Niv MY. Homology modeling of G-protein-coupled receptors with X-ray structures on the rise. Curr Opin Drug Discov Devel. 2010 May; 13(3):317-25. PMID: 20443165.

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Klipper E, Levit A, Mastich Y, Berisha B, Schams D, Meidan R. Induction of endothelin-2 expression by luteinizing hormone and hypoxia: possible role in bovine corpus luteum formation. Endocrinology. 2010 Apr; 151(4):1914-22. PMID: 20176726.

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Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R. Stargazin involvement with bipolar disorder and response to lithium treatment. Pharmacogenet Genomics. 2008 May; 18(5):403-12. PMID: 18408563.

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Shifman S, Levit A, Chen ML, Chen CH, Bronstein M, Weizman A, Yakir B, Navon R, Darvasi A. A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia. Hum Genet. 2006 Sep; 120(2):160-70. PMID: 16783572.

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