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Structural identification of a hotspot on CFTR for potentiation. Science. 2019 06 21; 364(6446):1184-1188.
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J. PMID: 31221859; PMCID: PMC7184887.
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PubMed Mentions:
116 Fields:
Translation:
HumansCells
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Ultra-large library docking for discovering new chemotypes. Nature. 2019 02; 566(7743):224-229.
Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ. PMID: 30728502; PMCID: PMC6383769.
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PubMed Mentions:
302 Fields:
Translation:
Humans
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Corrigendum: Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes. Front Mol Biosci. 2018; 5:84.
Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY. PMID: 30255025; PMCID: PMC6142832.
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The Recognition of Unrelated Ligands by Identical Proteins. ACS Chem Biol. 2018 09 21; 13(9):2522-2533.
Pottel J, Levit A, Korczynska M, Fischer M, Shoichet BK. PMID: 30095890; PMCID: PMC6499068.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14. Biochim Biophys Acta Gen Subj. 2018 10; 1862(10):2162-2173.
Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M. PMID: 30009876.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes. Front Mol Biosci. 2018; 5:9.
Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY. PMID: 29552563; PMCID: PMC5840161.
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PubMed Mentions:
11
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Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. Nature. 2018 03 08; 555(7695):269-273.
Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL. PMID: 29466326; PMCID: PMC5843546.
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PubMed Mentions:
165 Fields:
Translation:
HumansCells
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D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 10 20; 358(6361):381-386.
Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL. PMID: 29051383; PMCID: PMC5856174.
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PubMed Mentions:
96 Fields:
Translation:
HumansCells
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Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell. 2017 01 26; 168(3):377-389.e12.
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. PMID: 28129538; PMCID: PMC5289311.
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PubMed Mentions:
188 Fields:
Translation:
HumansCells
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Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 09 08; 537(7619):185-190.
Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. PMID: 27533032; PMCID: PMC5161585.
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PubMed Mentions:
394 Fields:
Translation:
HumansAnimalsCells
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Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios. Methods Cell Biol. 2016; 132:401-27.
Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY. PMID: 26928553.
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PubMed Mentions:
39 Fields:
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HumansCells
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Predicting GPCR promiscuity using binding site features. J Chem Inf Model. 2014 Jan 27; 54(1):184-94.
Levit A, Beuming T, Krilov G, Sherman W, Niv MY. PMID: 24328091.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. FASEB J. 2014 Mar; 28(3):1181-97.
Levit A, Nowak S, Peters M, Wiener A, Meyerhof W, Behrens M, Niv MY. PMID: 24285091.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J Neurosci. 2013 Jan 02; 33(1):201-13.
Born S, Levit A, Niv MY, Meyerhof W, Behrens M. PMID: 23283334; PMCID: PMC6618634.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Expression and structure/function relationships of human defensin 5. Appl Biochem Biotechnol. 2012 Apr; 166(7):1703-10.
Chapnik N, Levit A, Niv MY, Froy O. PMID: 22354633.
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PubMed Mentions:
4 Fields:
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HumansCells
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Homology model-assisted elucidation of binding sites in GPCRs. Methods Mol Biol. 2012; 914:179-205.
Levit A, Barak D, Behrens M, Meyerhof W, Niv MY. PMID: 22976029.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs. PLoS One. 2011; 6(11):e27990.
Levit A, Yarnitzky T, Wiener A, Meidan R, Niv MY. PMID: 22132188; PMCID: PMC3221691.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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BitterDB: a database of bitter compounds. Nucleic Acids Res. 2012 Jan; 40(Database issue):D413-9.
Wiener A, Shudler M, Levit A, Niv MY. PMID: 21940398; PMCID: PMC3245057.
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PubMed Mentions:
87 Fields:
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HumansCells
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Homology modeling of G-protein-coupled receptors with X-ray structures on the rise. Curr Opin Drug Discov Devel. 2010 May; 13(3):317-25.
Yarnitzky T, Levit A, Niv MY. PMID: 20443165.
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PubMed Mentions:
28 Fields:
Translation:
Cells
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Induction of endothelin-2 expression by luteinizing hormone and hypoxia: possible role in bovine corpus luteum formation. Endocrinology. 2010 Apr; 151(4):1914-22.
Klipper E, Levit A, Mastich Y, Berisha B, Schams D, Meidan R. PMID: 20176726.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Stargazin involvement with bipolar disorder and response to lithium treatment. Pharmacogenet Genomics. 2008 May; 18(5):403-12.
Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R. PMID: 18408563.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia. Hum Genet. 2006 Sep; 120(2):160-70.
Shifman S, Levit A, Chen ML, Chen CH, Bronstein M, Weizman A, Yakir B, Navon R, Darvasi A. PMID: 16783572.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells