Xianhua Piao, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address1651 4th Street
San Francisco CA 94158
Phone415-502-3460
ORCID ORCID Icon0000-0001-7540-6767 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CA2020Diversity, Equity, and Inclusion Champion Training
    Harvard Medical School , MA2005Postdoctoral Fellow
    Harvard Medical School , MA2002Neonatal-Perinatal Fellowship
    New York University, NY1999Pediatric Residency
    University of Toronto, Toronto, Canada1996Medical Science

    Collapse Overview 
    Collapse Overview
    Dr. Piao is a physician-scientist with a focus in both neonatology and developmental neuroscience. She received her PhD with Alan Bernstein from University of Toronto, before completing her Pediatric residency at NYU and Neonatology fellowship as well as a post-doctoral fellowship with Chris Walsh at Harvard Medical School. During her postdoctoral study, Dr. Piao discovered that the adhesion G-protein-coupled receptor (aGPCR) GPR56 regulates brain patterning and its mutations cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). After spending almost two decades at Harvard Medical School, Dr. Piao joined the Department of Pediatrics as the director of the Newborn Brain Research Institute and Benioff Professor in Children’s Health. Her research focuses on cells and molecules of the central nervous system (CNS) during development that execute an astonishingly intricate series of orchestrated steps to culminate in the precise localization of neurons wired in a functional networked circuitry. Her lab seeks to understand aspects of this process which persist into adulthood and may at times be deranged in neurodevelopmental disorders. One special area of interest concerns adhesion G protein-coupled receptors (aGPCRs) and their extracellular matrix (ECM) partners. This research engages three processes, each of which is governed in part by the cell-type-specific expression and function of aGPCRs:
    I. CNS myelin formation and repair. Piao and her colleagues recently showed how the aGPCR GPR56 regulates developmental myelin formation through a remarkable tripartite signaling complex composed of a microglial-derived ligand, an oligodendrocyte receptor and an extracellular matrix component.
    II. Synapses, circuits, and neurological disorders. Unpublished work from the Piao lab demonstrates a novel player in microglia-mediated developmental synaptic refinement. She is collaborating with investigators at UCSF and Harvard Medical School to decipher the molecular mechanisms by which glial cells regulate neural circuit formation during perinatal development and associated disease processes.
    III. Maternal immune activation (MIA) and neuropsychiatric disorders. She and her collaborator Jun Huh at Harvard Medical School are investigating how MIA deranges fetal and neonatal brain development through innate immune mechanisms.

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of cellular pathway in human brain development
    NIH/NINDS P01 NS083513Jul 1, 2020 - Jun 30, 2025
    Role: Leader, project 3
    Glial mechanisms of developmental synapse refinement
    NIH/NINDS R01NS108446Sep 1, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Adhesion GPCR interactome landscaping by in vivo biotinylation proteomics
    NIH/NINDS R21 NS108312Aug 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    Adhesion G protein-coupled receptors in CNS development and regeneration
    NIH/NINDS R01 NS094164Sep 30, 2015 - Mar 31, 2026
    Role: Principal Investigator
    Role of Adhesion G protein-coupled receptors in glial cell development and myelination
    NIH R56NS085201Mar 15, 2015 - Feb 28, 2017
    Role: Principal Investigator
    Regulation of Cortical Development by GPR56 Signaling
    NIH R01NS057536Dec 15, 2007 - Nov 30, 2013
    Role: Principal Investigator
    The Genetics of Polymicrogyria and Epilepsy
    NIH K08NS045762Jan 1, 2004 - May 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure. EMBO J. 2021 Sep 29; e107915. Li T, Yu D, Oak HC, Zhu B, Wang L, Jiang X, Molday RS, Kriegstein A, Piao X. PMID: 34585770.
      View in: PubMed   Mentions:    Fields:    
    2. Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids. Cell Stem Cell. 2021 Sep 16. Popova G, Soliman SS, Kim CN, Keefe MG, Hennick KM, Jain S, Li T, Tejera D, Shin D, Chhun BB, McGinnis CS, Speir M, Gartner ZJ, Mehta SB, Haeussler M, Hengen KB, Ransohoff RR, Piao X, Nowakowski TJ. PMID: 34536354.
      View in: PubMed   Mentions:    Fields:    
    3. The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California. Lancet Reg Health Am. 2021 Oct; 2:100027. Karasek D, Baer RJ, McLemore MR, Bell AJ, Blebu BE, Casey JA, Coleman-Phox K, Costello JM, Felder JN, Flowers E, Fuchs JD, Gomez AM, Karvonen K, Kuppermann M, Liang L, McKenzie-Sampson S, McCulloch CE, Oltman SP, Pantell MS, Piao X, Prather AA, Schmidt RJ, Scott KA, Spellen S, Stookey JD, Tesfalul M, Rand L, Jelliffe-Pawlowski LL. PMID: 34642685; PMCID: PMC8497178.
      View in: PubMed   Mentions:
    4. Association of Maternal Immune Activation during Pregnancy and Neurologic Outcomes in Offspring. J Pediatr. 2021 May 07. Jain S, Baer RJ, McCulloch CE, Rogers E, Rand L, Jelliffe-Pawlowski L, Piao X. PMID: 33965413.
      View in: PubMed   Mentions:    Fields:    
    5. Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. Blood Adv. 2021 02 09; 5(3):829-842. Maglitto A, Mariani SA, de Pater E, Rodriguez-Seoane C, Vink CS, Piao X, Lukke ML, Dzierzak E. PMID: 33560396.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28275-28286. Yeung J, Adili R, Stringham EN, Luo R, Vizurraga A, Rosselli-Murai LK, Stoveken HM, Yu M, Piao X, Holinstat M, Tall GG. PMID: 33097663.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Cell type-specific evaluation of ADGRG1/GPR56 function in developmental central nervous system myelination. Glia. 2021 02; 69(2):413-423. Chiou B, Gao C, Giera S, Folts CJ, Kishore P, Yu D, Oak HC, Jiang R, Piao X. PMID: 32902916.
      View in: PubMed   Mentions:    Fields:    
    8. A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding. EMBO J. 2020 08 17; 39(16):e104136. Li T, Chiou B, Gilman CK, Luo R, Koshi T, Yu D, Oak HC, Giera S, Johnson-Venkatesh E, Muthukumar AK, Stevens B, Umemori H, Piao X. PMID: 32452062.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    9. GAIN domain-mediated cleavage is required for activation of G protein-coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist. J Biol Chem. 2019 12 13; 294(50):19246-19254. Zhu B, Luo R, Jin P, Li T, Oak HC, Giera S, Monk KR, Lak P, Shoichet BK, Piao X. PMID: 31628191.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    10. The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2019 11; 1456(1):5-25. Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. PMID: 31168816.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Long noncoding RNAs interact with mRNAs: A new perspective on the mechanism of premature brain injury. Neurosci Lett. 2019 08 10; 707:134274. Chen R, Piao X, Xiao M, Wang F, Liu L. PMID: 31103728.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    12. Overlap of polymicrogyria, hydrocephalus, and Joubert syndrome in a family with novel truncating mutations in ADGRG1/GPR56 and KIAA0556. Neurogenetics. 2019 05; 20(2):91-98. Cauley ES, Hamed A, Mohamed IN, Elseed M, Martinez S, Yahia A, Abozar F, Abubakr R, Koko M, Elsayed L, Piao X, Salih MA, Manzini MC. PMID: 30982090.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases. Trends Pharmacol Sci. 2019 04; 40(4):278-293. Folts CJ, Giera S, Li T, Piao X. PMID: 30871735.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    14. Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity. 2019 01 15; 50(1):253-271.e6. Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll SA, Stevens B. PMID: 30471926.
      View in: PubMed   Mentions: 274     Fields:    Translation:HumansAnimalsCells
    15. The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function. Cell Mol Life Sci. 2018 Nov; 75(21):4007-4019. Olaniru OE, Pingitore A, Giera S, Piao X, Castañera González R, Jones PM, Persaud SJ. PMID: 29855662.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    16. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Elife. 2018 05 29; 7. Giera S, Luo R, Ying Y, Ackerman SD, Jeong SJ, Stoveken HM, Folts CJ, Welsh CA, Tall GG, Stevens B, Monk KR, Piao X. PMID: 29809138.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    17. GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. J Exp Med. 2018 03 05; 215(3):941-961. Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D'Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR. PMID: 29367382.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma. Cell Rep. 2017 Nov 21; 21(8):2183-2197. Moreno M, Pedrosa L, Paré L, Pineda E, Bejarano L, Martínez J, Balasubramaniyan V, Ezhilarasan R, Kallarackal N, Kim SH, Wang J, Audia A, Conroy S, Marin M, Ribalta T, Pujol T, Herreros A, Tortosa A, Mira H, Alonso MM, Gómez-Manzano C, Graus F, Sulman EP, Piao X, Nakano I, Prat A, Bhat KP, de la Iglesia N. PMID: 29166609.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    19. Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy. Muscle Nerve. 2017 05; 55(5):761-765. Mehta P, Küspert M, Bale T, Brownstein CA, Towne MC, De Girolami U, Shi J, Beggs AH, Darras BT, Wegner M, Piao X, Agrawal PB. PMID: 27668699.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    20. Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development. Dev Dyn. 2017 04; 246(4):275-284. Mehta P, Piao X. PMID: 27859941.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair. J Neurosci. 2016 12 07; 36(49):12351-12367. Mogha A, Harty BL, Carlin D, Joseph J, Sanchez NE, Suter U, Piao X, Cavalli V, Monk KR. PMID: 27927955.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    22. Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Neuron. 2016 Sep 21; 91(6):1292-1304. Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D. PMID: 27657451.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    23. Adhesion G protein-coupled receptors in nervous system development and disease. Nat Rev Neurosci. 2016 09; 17(9):550-61. Langenhan T, Piao X, Monk KR. PMID: 27466150.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    24. Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination. Handb Exp Pharmacol. 2016; 234:275-298. Sigoillot SM, Monk KR, Piao X, Selimi F, Harty BL. PMID: 27832492.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    25. Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. Acta Neuropathol. 2015 Nov; 130(5):605-18. Chen P, Piao X, Bonaldo P. PMID: 26419777.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    26. Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation. J Recept Signal Transduct Res. 2015 Jun; 35(3):220-3. Schöneberg T, Liebscher I, Luo R, Monk KR, Piao X. PMID: 26366621.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    27. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015 May; 14(3):307-22. Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. PMID: 25840412.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron. 2015 Feb 18; 85(4):755-69. Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, Monk KR. PMID: 25695270.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    29. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015 Jan 21; 6:6121. Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. PMID: 25607655.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    30. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nat Commun. 2015 Jan 21; 6:6122. Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR. PMID: 25607772.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    31. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015; 67(2):338-67. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. PMID: 25713288.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    32. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec; 1333:43-64. Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. PMID: 25424900.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    33. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15756-61. White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. PMID: 25336758.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    34. Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One. 2014; 9(6):e100043. Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Araç D, Piao X. PMID: 24949629.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    35. Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14; 343(6172):764-8. Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Šestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X, Walsh CA. PMID: 24531968.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    36. G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo. FEBS J. 2013 Dec; 280(23):6097-113. Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E. PMID: 24102982.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    37. GPR56 functions together with α3β1 integrin in regulating cerebral cortical development. PLoS One. 2013; 8(7):e68781. Jeong SJ, Luo R, Singer K, Giera S, Kreidberg J, Kiyozumi D, Shimono C, Sekiguchi K, Piao X. PMID: 23874761.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    38. Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2012 Dec; 1276:1-25. Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. PMID: 23215895.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    39. GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration. Mol Neurobiol. 2013 Feb; 47(1):186-96. Singer K, Luo R, Jeong SJ, Piao X. PMID: 23001883.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    40. Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. J Comp Neurol. 2012 Sep 01; 520(13):2930-40. Jeong SJ, Luo R, Li S, Strokes N, Piao X. PMID: 22351047.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    41. Disease-associated mutations prevent GPR56-collagen III interaction. PLoS One. 2012; 7(1):e29818. Luo R, Jin Z, Deng Y, Strokes N, Piao X. PMID: 22238662.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    42. Loss of Col3a1, the gene for Ehlers-Danlos syndrome type IV, results in neocortical dyslamination. PLoS One. 2012; 7(1):e29767. Jeong SJ, Li S, Luo R, Strokes N, Piao X. PMID: 22235340.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    43. G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12925-30. Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X. PMID: 21768377.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    44. A novel GPR56 mutation causes bilateral frontoparietal polymicrogyria. Pediatr Neurol. 2011 Jul; 45(1):49-53. Luo R, Yang HM, Jin Z, Halley DJ, Chang BS, MacPherson L, Brueton L, Piao X. PMID: 21723461.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    45. G protein-coupled receptor56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci USA, 108(31), 12925-30. 2011.
    46. Adhesion-GPCRs in the CNS. Adv Exp Med Biol. 2010; 706:87-97. Strokes N, Piao X. PMID: 21618828.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    47. GPR56 and its related diseases. Prog Mol Biol Transl Sci. 2009; 89:1-13. Jin Z, Luo R, Piao X. PMID: 20374731.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    48. GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. J Neurosci. 2009 Jun 10; 29(23):7439-49. Koirala S, Jin Z, Piao X, Corfas G. PMID: 19515912.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    49. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci. 2008 May 28; 28(22):5817-26. Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. PMID: 18509043.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    50. Disease-associated mutations affect GPR56 protein trafficking and cell surface expression. Hum Mol Genet. 2007 Aug 15; 16(16):1972-85. Jin Z, Tietjen I, Bu L, Liu-Yesucevitz L, Gaur SK, Walsh CA, Piao X. PMID: 17576745.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    51. Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes. Ann Neurol. 2005 Nov; 58(5):680-7. Piao X, Chang BS, Bodell A, Woods K, Benzeev B, Topcu M, Guerrini R, Goldberg-Stern H, Sztriha L, Dobyns WB, Barkovich AJ, Walsh CA. PMID: 16240336.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    52. A novel signaling mechanism in brain development. Pediatr Res. 2004 Sep; 56(3):309-10. Piao X, Walsh CA. PMID: 15269343.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    53. G protein-coupled receptor-dependent development of human frontal cortex. Science. 2004 Mar 26; 303(5666):2033-6. Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Ross ME, Michaud JL, Déscarie JC, Barkovich AJ, Walsh CA. PMID: 15044805.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    54. G protein-coupled receptor-dependent development of human frontal cortex. Science. 2004.
    55. Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16. Ann Neurol. 2003 May; 53(5):596-606. Chang BS, Piao X, Bodell A, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Grant PE, Barkovich AJ, Walsh CA. PMID: 12730993.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    56. An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21. Am J Hum Genet. 2002 Apr; 70(4):1028-33. Piao X, Basel-Vanagaite L, Straussberg R, Grant PE, Pugh EW, Doheny K, Doan B, Hong SE, Shugart YY, Walsh CA. PMID: 11845408.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    57. recessive spotting: a linked locus that interacts with W/Kit but is not allelic. Genes Cells. 1998 Apr; 3(4):235-44. Bennett DC, Trayner ID, Piao X, Easty DJ, Klüppel M, Alexander WS, Wagner EF, Bernstein A. PMID: 9663658.
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    58. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14665-9. Piao X, Paulson R, van der Geer P, Pawson T, Bernstein A. PMID: 8962111.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    59. A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells. Blood. 1996 Apr 15; 87(8):3117-23. Piao X, Bernstein A. PMID: 8605325.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    60. Minimal residual disease in bone marrow transplant recipients with chronic myeloid leukemia. Bone Marrow Transplant. 1994 Aug; 14(2):299-306. Xu WM, Piao XH, Addy L, Jamal M, Minden MD, Messner HA. PMID: 7994246.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    61. Expression of the Kit and KitA receptor isoforms in human acute myelogenous leukemia. Blood. 1994 Jan 15; 83(2):476-81. Piao X, Curtis JE, Minkin S, Minden MD, Bernstein A. PMID: 7506952.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    62. The preliminary observation on immunosuppressive effect of norcantharidin in mice. Immunopharmacol Immunotoxicol. 1993 Jan; 15(1):79-85. Yan MS, Xiue S, Wei LX, Piao XH. PMID: 8450182.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    63. Monoclonal antibody 55 (CD10) and complement used for purging autologous bone marrow in common acute lymphoblastic leukemia. Chin Med J (Engl). 1990 May; 103(5):385-90. Bai Y, Piao XH, Luo QL, Mao BZ. PMID: 2118055.
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