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Aashish Manglik, MD, PhD

Title(s)Assistant Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th St
San Francisco CA 94158
Phone415-502-3744
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    Collapse Biography 
    Collapse Education and Training
    Washington University in St. Louis, St. Louis, MOB.A.05/2008Chemistry and Biology
    Stanford University, Stanford, CAPh.D.02/2014Biophysics
    Stanford University, Stanford, CAM.D.05/2016
    Collapse Awards and Honors
    Washington University in St. Louis2008Spector Award
    Scientific American201330 under 30
    National Institutes of Health2016  - 2021Director's Early Independence Award
    International Narcotics Research Conference2017Young Investigator Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Precision pharmacology by local control of opioid receptors in neural circuits
    NIH/NIDA R61DA051531Aug 1, 2020 - Apr 30, 2023
    Role: Co-Principal Investigator
    Molecular Mechanisms of Iron Homeostasis
    NIH DP5OD023048Aug 15, 2017 - Aug 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization. bioRxiv. 2020 Jul 15. Wang B, Asarnow D, Lee WH, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Hu Y, Seah SGK, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. PMID: 32699850.
      View in: PubMed   Mentions:
    2. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32511497.
      View in: PubMed   Mentions:
    3. ß-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19. Circulation. 2020 May 15. Manglik A, Wingler LM, Rockman HA, Lefkowitz RJ. PMID: 32412788.
      View in: PubMed   Mentions:    Fields:    
    4. Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells. Elife. 2020 Feb 25; 9. Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M. PMID: 32096468.
      View in: PubMed   Mentions: 1     Fields:    
    5. Molecular Basis of Opioid Action: From Structures to New Leads. Biol Psychiatry. 2020 Jan 01; 87(1):6-14. Manglik A. PMID: 31653480.
      View in: PubMed   Mentions: 2     Fields:    
    6. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature. 2019 07; 571(7764):284-288. Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. PMID: 31263273.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun. 2018 09 13; 9(1):3712. Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK. PMID: 30213947.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. Elife. 2018 06 22; 7. Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR. PMID: 29932421.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Structure of the µ-opioid receptor-Gi protein complex. Nature. 2018 06; 558(7711):547-552. Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK. PMID: 29899455.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    10. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron. 2018 06 06; 98(5):963-976.e5. Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M. PMID: 29754753.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in ß-arrestin coupling. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3834-3839. Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. PMID: 29581292.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nat Struct Mol Biol. 2018 03; 25(3):289-296. McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC. PMID: 29434346.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. Structural Basis for G Protein-Coupled Receptor Activation. Biochemistry. 2017 10 24; 56(42):5628-5634. Manglik A, Kruse AC. PMID: 28967738.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    14. Nanobodies to Study G Protein-Coupled Receptor Structure and Function. Annu Rev Pharmacol Toxicol. 2017 01 06; 57:19-37. Manglik A, Kobilka BK, Steyaert J. PMID: 27959623.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    15. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 09 08; 537(7619):185-190. Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. PMID: 27533032.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    16. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. 2016 07 21; 535(7612):448-52. Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. PMID: 27409812.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    17. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. 2016 07 07; 535(7610):182-6. DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. PMID: 27362234.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    18. Crystal structure of the human s1 receptor. Nature. 2016 Apr 28; 532(7600):527-30. Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC. PMID: 27042935.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    19. High-density grids for efficient data collection from multiple crystals. Acta Crystallogr D Struct Biol. 2016 Jan; 72(Pt 1):2-11. Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE. PMID: 26894529.
      View in: PubMed   Mentions:
    20. Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6506-14. Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. PMID: 26604307.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    21. Structural Insights into the Dynamic Process of ß2-Adrenergic Receptor Signaling. Cell. 2015 Sep 1; 162(6):1431. Aashish Manglik, Tae Hun Kim, Matthieu Masureel, Christian Altenbach, Zhongyu Yang, Daniel Hilger, Michael T. Lerch, Tong Sun Kobilka, Foon Sun Thian, Wayne L. Hubbell, R. Scott Prosser, Brian K. Kobilka. .
      View in: Publisher Site   Mentions:
    22. Propagation of conformational changes during µ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):375-8. Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. PMID: 26245377.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    23. Structural insights into µ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):315-21. Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. PMID: 26245379.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    24. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science. 2015 Jun 19; 348(6241):1361-5. Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. PMID: 26089515.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    25. Structural Insights into the Dynamic Process of ß2-Adrenergic Receptor Signaling. Cell. 2015 May 21; 161(5):1101-1111. Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. PMID: 25981665.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    26. A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹?F NMR studies of proteins. J Biomol NMR. 2015 May; 62(1):97-103. Ye L, Larda ST, Frank Li YF, Manglik A, Prosser RS. PMID: 25813845.
      View in: PubMed   Mentions: 7     Fields:    
    27. G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs). J Biol Chem. 2015 Apr 24; 290(17):10775-90. Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV. PMID: 25770216.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Goniometer-based femtosecond crystallography with X-ray free electron lasers. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17122-7. Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO. PMID: 25362050.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    29. Covalent agonists for studying G protein-coupled receptor activation. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10744-8. Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. PMID: 25006259.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    30. The role of protein dynamics in GPCR function: insights from the ß2AR and rhodopsin. Curr Opin Cell Biol. 2014 Apr; 27:136-43. Manglik A, Kobilka B. PMID: 24534489.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    31. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Dec 05; 504(7478):101-6. Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. PMID: 24256733.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansCells
    32. Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr. 2013 Nov; 69(Pt 11):2287-92. Kruse AC, Manglik A, Kobilka BK, Weis WI. PMID: 24189241.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    33. Adrenaline-activated structure of ß2-adrenoceptor stabilized by an engineered nanobody. Nature. 2013 Oct 24; 502(7472):575-579. Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. PMID: 24056936.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    34. The role of ligands on the equilibria between functional states of a G protein-coupled receptor. J Am Chem Soc. 2013 Jun 26; 135(25):9465-74. Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS. PMID: 23721409.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    35. Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 2013 May 02; 497(7447):137-41. Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ. PMID: 23604254.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    36. Corrigendum: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. Chemistry - A European Journal. 2013 Apr 15; 19(16):4964-4964. Pil Seok Chae, Søren G. F. Rasmussen, Rohini R. Rana, Kamil Gotfryd, Andrew C. Kruse, Aashish Manglik, Kyung Ho Cho, Shailika Nurva, Ulrik Gether, Lan Guan, Claus J. Loland, Bernadette Byrne, Brian K. Kobilka, Samuel H. Gellman. .
      View in: Publisher Site   Mentions:
    37. Crystal structure of active Beta-arrestin1 bound to phosphorylated carboxy-terminus of a G protein-coupled receptor. The FASEB Journal. 2013 Apr 1; 27:lb549-lb549. Arun K. Shukla, Aashish Manglik, Andrew Kruse, Rosana Reis, Wei Chou Tseng, Dean P. Staus, Daniel Hilger, Serdar Uysal, LiYin Huang, Marcin Peduch, Prachi Tripathi-Shukla, Akiko Koide, Shohei Koide, William I. Weis, Anthony K. Kossiakoff, Brian K. Kobilka, Robert J. Lefkowitz. .
      View in: Publisher Site   Mentions:
    38. The dynamic process of ß(2)-adrenergic receptor activation. Cell. 2013 Jan 31; 152(3):532-42. Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. PMID: 23374348.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansCells
    39. Role of detergents in conformational exchange of a G protein-coupled receptor. J Biol Chem. 2012 Oct 19; 287(43):36305-11. Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, Prosser RS. PMID: 22893704.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    40. Inside Cover: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins (Chem. Eur. J. 31/2012). Chemistry - A European Journal. 2012 Jul 27; 18(31):9434-9434. Pil Seok Chae, Søren G. F. Rasmussen, Rohini R. Rana, Kamil Gotfryd, Andrew C. Kruse, Aashish Manglik, Kyung Ho Cho, Shailika Nurva, Ulrik Gether, Lan Guan, Claus J. Loland, Bernadette Byrne, Brian K. Kobilka, Samuel H. Gellman. .
      View in: Publisher Site   Mentions:
    41. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry. 2012 Jul 27; 18(31):9485-90. Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. PMID: 22730191.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    42. Structure of the d-opioid receptor bound to naltrindole. Nature. 2012 May 16; 485(7398):400-4. Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK. PMID: 22596164.
      View in: PubMed   Mentions: 212     Fields:    Translation:AnimalsCells
    43. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 Mar 21; 485(7398):321-6. Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. PMID: 22437502.
      View in: PubMed   Mentions: 390     Fields:    Translation:AnimalsCells
    44. Stably integrated luxCDABE for assessment of Salmonella invasion kinetics. Mol Imaging. 2008 Sep-Oct; 7(5):222-33. Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. PMID: 19123992.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells