Aashish Manglik, MD, PhD

Title(s)Associate Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th Street
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Washington University in St. Louis, St. Louis, MOB.A.05/2008Chemistry and Biology
    Stanford University, Stanford, CAPh.D.02/2014Biophysics
    Stanford University, Stanford, CAM.D.05/2016
    Collapse Awards and Honors
    Washington University in St. Louis2008Spector Award
    Scientific American201330 under 30
    National Institutes of Health2016  - 2021Director's Early Independence Award
    International Narcotics Research Conference2017Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Our laboratory seeks to understand how cells sense and respond to their external environment. In this endeavor, we study the numerous proteins that lie at the cellular surface that enable individual cells to decipher the enormous number of stimuli that coordinate normal physiology. To gain a fundamental understanding of such transmembrane signaling processes, we use a diverse array of techniques spanning biochemical and biophysical interrogation to protein engineering. Our ultimate goal is to use these insights to discover new approaches to precisely control cellular signaling.

    Collapse Research 
    Collapse Research Activities and Funding
    Biochemical approaches to enlighten GPR85 function
    NIH R03TR003384Sep 1, 2020 - Aug 31, 2021
    Role: Principal Investigator
    Precision pharmacology by local control of opioid receptors in neural circuits
    NIH R61DA051531Aug 1, 2020 - Apr 30, 2023
    Role: Co-Principal Investigator
    Molecular Mechanisms of Iron Homeostasis
    NIH DP5OD023048Sep 19, 2016 - Aug 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Academic Senate

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature. 2022 Aug 08. Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A. PMID: 35940205.
      View in: PubMed   Mentions:
    2. Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun. 2022 Jul 28; 13(1):4366. Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y. PMID: 35902590; PMCID: PMC9334595.
      View in: PubMed   Mentions:    Fields:    
    3. Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody. Methods Mol Biol. 2022; 2374:149-160. Deshpande I, Manglik A. PMID: 34562250.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat Chem Biol. 2022 01; 18(1):109-115. Harris JA, Faust B, Gondin AB, Dämgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A. PMID: 34711980; PMCID: PMC8712391.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    5. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19. Verba K, Gupta M, Azumaya C, Moritz M, Pourmal S, Diallo A, Merz G, Jang G, Bouhaddou M, Fossati A, Brilot A, Diwanji D, Hernandez E, Herrera N, Kratochvil H, Lam V, Li F, Li Y, Nguyen H, Nowotny C, Owens T, Peters J, Rizo A, Schulze-Gahmen U, Smith A, Young I, Yu Z, Asarnow D, Billesbølle C, Campbell M, Chen J, Chen KH, Chio US, Dickinson M, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez K, Mancino A, Iii FM, Paul M, Pawar K, Pelin A, Pospiech T, Puchades C, Remesh S, Safari M, Schaefer K, Sun M, Tabios M, Thwin A, Titus E, Trenker R, Tse E, Tsui TKM, Feng F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, Agard D, Cheng Y, Fraser J, Jura N, Kortemme T, Manglik A, Southworth D, Stroud R, Swaney D, Krogan N, Frost A, Rosenberg O. PMID: 34031651; PMCID: PMC8142659.
      View in: PubMed   Mentions: 1  
    6. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
      View in: PubMed   Mentions:
    7. Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. Cell. 2021 06 10; 184(12):3192-3204.e16. Asarnow D, Wang B, Lee WH, Hu Y, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Ary B, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Seah SGK, Chan CEZ, Connelly E, Young NJ, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. PMID: 33974910; PMCID: PMC8064868.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    8. Protein design and variant prediction using autoregressive generative models. Nat Commun. 2021 04 23; 12(1):2403. Shin JE, Riesselman AJ, Kollasch AW, McMahon C, Simon E, Sander C, Manglik A, Kruse AC, Marks DS. PMID: 33893299; PMCID: PMC8065141.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    9. Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biol. 2021 04; 19(4):e3001191. Arveseth CD, Happ JT, Hedeen DS, Zhu JF, Capener JL, Klatt Shaw D, Deshpande I, Liang J, Xu J, Stubben SL, Nelson IB, Walker MF, Kawakami K, Inoue A, Krogan NJ, Grunwald DJ, Hüttenhain R, Manglik A, Myers BR. PMID: 33886552; PMCID: PMC8096101.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    10. Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL. Cancer Discov. 2021 08; 11(8):2032-2049. Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik A, Stieglitz E, Wiita AP. PMID: 33727310; PMCID: PMC8338785.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 12 18; 370(6523):1473-1479. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 33154106; PMCID: PMC7857409.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    12. Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc Natl Acad Sci U S A. 2020 11 17; 117(46):28838-28846. Zhang Y, Lu WJ, Bulkley DP, Liang J, Ralko A, Han S, Roberts KJ, Li A, Cho W, Cheng Y, Manglik A, Beachy PA. PMID: 33139559; PMCID: PMC7682405.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    13. Universal Polymerase Chain Reaction and Antibody Testing Demonstrate Little to No Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in a Rural Community. Open Forum Infect Dis. 2021 Jan; 8(1):ofaa531. Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu C, Havlir D, Greenhouse B. PMID: 34109255; PMCID: PMC7665736.
      View in: PubMed   Mentions: 7  
    14. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, et al. PMID: 33060197; PMCID: PMC7808408.
      View in: PubMed   Mentions: 208     Fields:    Translation:HumansCells
    15. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 10; 38(10):1174-1183. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32855547; PMCID: PMC7740072.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCellsPHPublic Health
    16. Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature. 2020 10; 586(7831):807-811. Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A. PMID: 32814342; PMCID: PMC7906036.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    17. An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation. bioRxiv. 2020 Aug 17. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 32817938; PMCID: PMC7430568.
      View in: PubMed   Mentions: 1  
    18. Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community. medRxiv. 2020 Aug 17. Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Consortium C, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu C, Havlir D, Greenhouse B. PMID: 32839781; PMCID: PMC7444294.
      View in: PubMed   Mentions:
    19. Author Correction: Structural insights into μ-opioid receptor activation. Nature. 2020 Aug; 584(7820):E16. Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. PMID: 32724208.
      View in: PubMed   Mentions: 1     Fields:    
    20. Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization. bioRxiv. 2020 Jul 15. Wang B, Asarnow D, Lee WH, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Hu Y, Seah SGK, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. PMID: 32699850; PMCID: PMC7373131.
      View in: PubMed   Mentions:
    21. β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19. Circulation. 2020 07 28; 142(4):318-320. Manglik A, Wingler LM, Rockman HA, Lefkowitz RJ. PMID: 32412788; PMCID: PMC7382535.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    22. Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells. Elife. 2020 02 25; 9. Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M. PMID: 32096468; PMCID: PMC7041944.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    23. Molecular Basis of Opioid Action: From Structures to New Leads. Biol Psychiatry. 2020 01 01; 87(1):6-14. Manglik A. PMID: 31653480; PMCID: PMC6898784.
      View in: PubMed   Mentions: 11     Fields:    
    24. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature. 2019 07; 571(7764):284-288. Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. PMID: 31263273; PMCID: PMC6709672.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    25. Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun. 2018 09 13; 9(1):3712. Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK. PMID: 30213947; PMCID: PMC6137068.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    26. Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. Elife. 2018 06 22; 7. Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR. PMID: 29932421; PMCID: PMC6042960.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    27. Structure of the µ-opioid receptor-Gi protein complex. Nature. 2018 06; 558(7711):547-552. Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK. PMID: 29899455; PMCID: PMC6317904.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    28. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron. 2018 06 06; 98(5):963-976.e5. Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M. PMID: 29754753; PMCID: PMC6481295.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    29. Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3834-3839. Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. PMID: 29581292; PMCID: PMC5899476.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    30. Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nat Struct Mol Biol. 2018 03; 25(3):289-296. McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC. PMID: 29434346; PMCID: PMC5839991.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    31. Structural Basis for G Protein-Coupled Receptor Activation. Biochemistry. 2017 10 24; 56(42):5628-5634. Manglik A, Kruse AC. PMID: 28967738; PMCID: PMC6613644.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    32. Nanobodies to Study G Protein-Coupled Receptor Structure and Function. Annu Rev Pharmacol Toxicol. 2017 01 06; 57:19-37. Manglik A, Kobilka BK, Steyaert J. PMID: 27959623; PMCID: PMC5500200.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    33. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 09 08; 537(7619):185-190. Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. PMID: 27533032; PMCID: PMC5161585.
      View in: PubMed   Mentions: 304     Fields:    Translation:HumansAnimalsCells
    34. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. 2016 07 21; 535(7612):448-52. Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. PMID: 27409812; PMCID: PMC4961583.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    35. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. 2016 07 07; 535(7610):182-6. DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. PMID: 27362234; PMCID: PMC5702553.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    36. Crystal structure of the human σ1 receptor. Nature. 2016 Apr 28; 532(7600):527-30. Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC. PMID: 27042935; PMCID: PMC5550834.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansCells
    37. High-density grids for efficient data collection from multiple crystals. Acta Crystallogr D Struct Biol. 2016 Jan; 72(Pt 1):2-11. Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE. PMID: 26894529; PMCID: PMC4756618.
      View in: PubMed   Mentions: 32  Translation:HumansAnimalsCells
    38. Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6506-14. Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. PMID: 26604307; PMCID: PMC4664306.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    39. Structural Insights into the Dynamic Process of ß2-Adrenergic Receptor Signaling. Cell. 2015 Sep 1; 162(6):1431. Manglik MA, Kim KT, Masureel MM, Altenbach AC, Yang YZ, Hilger HD, Lerch LM, Kobilka KT, Thian TF, Hubbell HW, Prosser PR, Kobilka KB. .
      View in: Publisher Site   Mentions:
    40. Propagation of conformational changes during μ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):375-8. Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. PMID: 26245377; PMCID: PMC4820006.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    41. Structural insights into µ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):315-21. Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. PMID: 26245379; PMCID: PMC4639397.
      View in: PubMed   Mentions: 307     Fields:    Translation:AnimalsCells
    42. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science. 2015 Jun 19; 348(6241):1361-5. Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. PMID: 26089515; PMCID: PMC4968074.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    43. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling. Cell. 2015 May 21; 161(5):1101-1111. Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. PMID: 25981665; PMCID: PMC4441853.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansCells
    44. A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins. J Biomol NMR. 2015 May; 62(1):97-103. Ye L, Larda ST, Frank Li YF, Manglik A, Prosser RS. PMID: 25813845; PMCID: PMC6675403.
      View in: PubMed   Mentions: 18     Fields:    
    45. G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs). J Biol Chem. 2015 Apr 24; 290(17):10775-90. Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV. PMID: 25770216; PMCID: PMC4409243.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    46. Goniometer-based femtosecond crystallography with X-ray free electron lasers. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17122-7. Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO. PMID: 25362050; PMCID: PMC4260607.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    47. Covalent agonists for studying G protein-coupled receptor activation. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10744-8. Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. PMID: 25006259; PMCID: PMC4115510.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    48. The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin. Curr Opin Cell Biol. 2014 Apr; 27:136-43. Manglik A, Kobilka B. PMID: 24534489; PMCID: PMC3986065.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    49. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Dec 05; 504(7478):101-6. Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. PMID: 24256733; PMCID: PMC4020789.
      View in: PubMed   Mentions: 329     Fields:    Translation:HumansCells
    50. Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr. 2013 Nov; 69(Pt 11):2287-92. Kruse AC, Manglik A, Kobilka BK, Weis WI. PMID: 24189241; PMCID: PMC3817703.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    51. Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature. 2013 Oct 24; 502(7472):575-579. Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. PMID: 24056936; PMCID: PMC3822040.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansCells
    52. The role of ligands on the equilibria between functional states of a G protein-coupled receptor. J Am Chem Soc. 2013 Jun 26; 135(25):9465-74. Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS. PMID: 23721409; PMCID: PMC3763947.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    53. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 2013 May 02; 497(7447):137-41. Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ. PMID: 23604254; PMCID: PMC3654799.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    54. Corrigendum: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. Chemistry - A European Journal. 2013 Apr 15; 19(16):4964-4964. Chae CP, Rasmussen RS, Rana RR, Gotfryd GK, Kruse KA, Manglik MA, Cho CK, Nurva NS, Gether GU, Guan GL, Loland LC, Byrne BB, Kobilka KB, Gellman GS. .
      View in: Publisher Site   Mentions:
    55. Crystal structure of active Beta-arrestin1 bound to phosphorylated carboxy-terminus of a G protein-coupled receptor. The FASEB Journal. 2013 Apr 1; 27:lb549-lb549. Shukla SA, Manglik MA, Kruse KA, Reis RR, Tseng TW, Staus SD, Hilger HD, Uysal US, Huang HL, Peduch PM, Tripathi-Shukla TP, Koide KA, Koide KS, Weis WW, Kossiakoff KA, Kobilka KB, Lefkowitz LR. .
      View in: Publisher Site   Mentions:
    56. The dynamic process of β(2)-adrenergic receptor activation. Cell. 2013 Jan 31; 152(3):532-42. Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. PMID: 23374348; PMCID: PMC3586676.
      View in: PubMed   Mentions: 327     Fields:    Translation:HumansCells
    57. Role of detergents in conformational exchange of a G protein-coupled receptor. J Biol Chem. 2012 Oct 19; 287(43):36305-11. Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, Prosser RS. PMID: 22893704; PMCID: PMC3476297.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    58. Inside Cover: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins (Chem. Eur. J. 31/2012). Chemistry - A European Journal. 2012 Jul 27; 18(31):9434-9434. Chae CP, Rasmussen RS, Rana RR, Gotfryd GK, Kruse KA, Manglik MA, Cho CK, Nurva NS, Gether GU, Guan GL, Loland LC, Byrne BB, Kobilka KB, Gellman GS. .
      View in: Publisher Site   Mentions:
    59. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry. 2012 Jul 27; 18(31):9485-90. Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. PMID: 22730191; PMCID: PMC3493560.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    60. Structure of the δ-opioid receptor bound to naltrindole. Nature. 2012 May 16; 485(7398):400-4. Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK. PMID: 22596164; PMCID: PMC3523198.
      View in: PubMed   Mentions: 269     Fields:    Translation:AnimalsCells
    61. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 Mar 21; 485(7398):321-6. Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. PMID: 22437502; PMCID: PMC3523197.
      View in: PubMed   Mentions: 551     Fields:    Translation:AnimalsCells
    62. Stably integrated luxCDABE for assessment of Salmonella invasion kinetics. Mol Imaging. 2008 Sep-Oct; 7(5):222-33. Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. PMID: 19123992; PMCID: PMC2743400.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
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