Aashish Manglik, MD, PhD
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Title(s) | Assistant Professor, Pharmaceutical Chemistry |
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School | School of Pharmacy |
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Address | 1700 4th St San Francisco CA 94158
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Phone | 415-502-3744 |
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vCard | Download vCard |
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Biography Washington University in St. Louis, St. Louis, MO | B.A. | 05/2008 | Chemistry and Biology | Stanford University, Stanford, CA | Ph.D. | 02/2014 | Biophysics | Stanford University, Stanford, CA | M.D. | 05/2016 | |
Washington University in St. Louis | 2008 | | Spector Award | Scientific American | 2013 | | 30 under 30 | National Institutes of Health | 2016
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| 2021 | Director's Early Independence Award | International Narcotics Research Conference | 2017 | | Young Investigator Award |
Overview Our laboratory seeks to understand how cells sense and respond to their external environment. In this endeavor, we study the numerous proteins that lie at the cellular surface that enable individual cells to decipher the enormous number of stimuli that coordinate normal physiology. To gain a fundamental understanding of such transmembrane signaling processes, we use a diverse array of techniques spanning biochemical and biophysical interrogation to protein engineering. Our ultimate goal is to use these insights to discover new approaches to precisely control cellular signaling.
Research ORNG Applications Bibliographic
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An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 12 18; 370(6523):1473-1479.
Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, Walter P, Manglik A. PMID: 33154106.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc Natl Acad Sci U S A. 2020 Nov 17; 117(46):28838-28846.
Zhang Y, Lu WJ, Bulkley DP, Liang J, Ralko A, Han S, Roberts KJ, Li A, Cho W, Cheng Y, Manglik A, Beachy PA. PMID: 33139559.
View in: PubMed Mentions: Fields:
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Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community. Open Forum Infectious Diseases. 2020 Oct 30.
Ayesha Appa, Saki Takahashi, Isabel Rodriguez-Barraquer, Gabriel Chamie, Aenor Sawyer, Elias Duarte, Jill Hakim, Keirstinne Turcios, Joanna Vinden, Owen Janson, Aashish Manglik, Michael J Peluso, Steven G Deeks, Timothy J Henrich, Leonel Torres, Mary Rodgers, John Hackett, Charles Chiu, Diane Havlir, Bryan Greenhouse. .
View in: Publisher Site Mentions:
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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521).
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ. PMID: 33060197.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 10; 38(10):1174-1183.
Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32855547.
View in: PubMed Mentions: 14 Fields: Translation: HumansCellsPHPublic Health
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Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature. 2020 10; 586(7831):807-811.
Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A. PMID: 32814342.
View in: PubMed Mentions: 1 Fields:
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Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community. medRxiv. 2020 Aug 17.
Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu CY, Havlir D, Greenhouse B. PMID: 32839781.
View in: PubMed Mentions:
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An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation. bioRxiv. 2020 Aug 10.
Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Zimanyi M, Deshpande I, Liang J, Anand AA, Dobzinski N, Zha BS, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Gupta S, Simoneau CR, Leon K, White KM, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, Walter P, Manglik A. PMID: 32817938.
View in: PubMed Mentions:
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Author Correction: Structural insights into µ-opioid receptor activation. Nature. 2020 Aug; 584(7820):E16.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. PMID: 32724208.
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Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization. bioRxiv. 2020 Jul 15.
Wang B, Asarnow D, Lee WH, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Hu Y, Seah SGK, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. PMID: 32699850.
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Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17.
Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32511497.
View in: PubMed Mentions:
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ß-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19. Circulation. 2020 07 28; 142(4):318-320.
Manglik A, Wingler LM, Rockman HA, Lefkowitz RJ. PMID: 32412788.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCellsPHPublic Health
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Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells. Elife. 2020 Feb 25; 9.
Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M. PMID: 32096468.
View in: PubMed Mentions: 6 Fields:
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Molecular Basis of Opioid Action: From Structures to New Leads. Biol Psychiatry. 2020 01 01; 87(1):6-14.
Manglik A. PMID: 31653480.
View in: PubMed Mentions: 6 Fields:
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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature. 2019 07; 571(7764):284-288.
Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. PMID: 31263273.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun. 2018 09 13; 9(1):3712.
Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK. PMID: 30213947.
View in: PubMed Mentions: 10 Fields: Translation: HumansCells
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Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. Elife. 2018 06 22; 7.
Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR. PMID: 29932421.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Structure of the µ-opioid receptor-Gi protein complex. Nature. 2018 06; 558(7711):547-552.
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK. PMID: 29899455.
View in: PubMed Mentions: 71 Fields: Translation: HumansAnimalsCells
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A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron. 2018 06 06; 98(5):963-976.e5.
Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M. PMID: 29754753.
View in: PubMed Mentions: 33 Fields: Translation: HumansAnimalsCells
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Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in ß-arrestin coupling. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3834-3839.
Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. PMID: 29581292.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nat Struct Mol Biol. 2018 03; 25(3):289-296.
McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC. PMID: 29434346.
View in: PubMed Mentions: 42 Fields: Translation: HumansAnimalsCells
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Structural Basis for G Protein-Coupled Receptor Activation. Biochemistry. 2017 10 24; 56(42):5628-5634.
Manglik A, Kruse AC. PMID: 28967738.
View in: PubMed Mentions: 27 Fields: Translation: HumansAnimalsCells
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Nanobodies to Study G Protein-Coupled Receptor Structure and Function. Annu Rev Pharmacol Toxicol. 2017 01 06; 57:19-37.
Manglik A, Kobilka BK, Steyaert J. PMID: 27959623.
View in: PubMed Mentions: 31 Fields: Translation: HumansAnimalsCells
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Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 09 08; 537(7619):185-190.
Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. PMID: 27533032.
View in: PubMed Mentions: 168 Fields: Translation: HumansAnimalsCells
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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. 2016 07 21; 535(7612):448-52.
Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. PMID: 27409812.
View in: PubMed Mentions: 75 Fields: Translation: HumansCells
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Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. 2016 07 07; 535(7610):182-6.
DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. PMID: 27362234.
View in: PubMed Mentions: 53 Fields: Translation: HumansCells
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Crystal structure of the human s1 receptor. Nature. 2016 Apr 28; 532(7600):527-30.
Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC. PMID: 27042935.
View in: PubMed Mentions: 86 Fields: Translation: HumansCells
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High-density grids for efficient data collection from multiple crystals. Acta Crystallogr D Struct Biol. 2016 Jan; 72(Pt 1):2-11.
Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE. PMID: 26894529.
View in: PubMed Mentions:
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Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6506-14.
Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. PMID: 26604307.
View in: PubMed Mentions: 68 Fields: Translation: HumansAnimalsCells
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Structural Insights into the Dynamic Process of ß2-Adrenergic Receptor Signaling. Cell. 2015 Sep 1; 162(6):1431.
Aashish Manglik, Tae Hun Kim, Matthieu Masureel, Christian Altenbach, Zhongyu Yang, Daniel Hilger, Michael T. Lerch, Tong Sun Kobilka, Foon Sun Thian, Wayne L. Hubbell, R. Scott Prosser, Brian K. Kobilka. .
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Propagation of conformational changes during µ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):375-8.
Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. PMID: 26245377.
View in: PubMed Mentions: 71 Fields: Translation: AnimalsCells
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Structural insights into µ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):315-21.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. PMID: 26245379.
View in: PubMed Mentions: 193 Fields: Translation: AnimalsCells
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SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science. 2015 Jun 19; 348(6241):1361-5.
Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. PMID: 26089515.
View in: PubMed Mentions: 70 Fields: Translation: HumansCells
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Structural Insights into the Dynamic Process of ß2-Adrenergic Receptor Signaling. Cell. 2015 May 21; 161(5):1101-1111.
Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. PMID: 25981665.
View in: PubMed Mentions: 166 Fields: Translation: HumansCells
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A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins. J Biomol NMR. 2015 May; 62(1):97-103.
Ye L, Larda ST, Frank Li YF, Manglik A, Prosser RS. PMID: 25813845.
View in: PubMed Mentions: 12 Fields:
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G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs). J Biol Chem. 2015 Apr 24; 290(17):10775-90.
Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV. PMID: 25770216.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimalsCells
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Goniometer-based femtosecond crystallography with X-ray free electron lasers. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17122-7.
Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO. PMID: 25362050.
View in: PubMed Mentions: 50 Fields: Translation: Cells
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Covalent agonists for studying G protein-coupled receptor activation. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10744-8.
Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. PMID: 25006259.
View in: PubMed Mentions: 16 Fields: Translation: Humans
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The role of protein dynamics in GPCR function: insights from the ß2AR and rhodopsin. Curr Opin Cell Biol. 2014 Apr; 27:136-43.
Manglik A, Kobilka B. PMID: 24534489.
View in: PubMed Mentions: 59 Fields: Translation: HumansCells
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Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Dec 05; 504(7478):101-6.
Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. PMID: 24256733.
View in: PubMed Mentions: 233 Fields: Translation: HumansCells
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Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr. 2013 Nov; 69(Pt 11):2287-92.
Kruse AC, Manglik A, Kobilka BK, Weis WI. PMID: 24189241.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Adrenaline-activated structure of ß2-adrenoceptor stabilized by an engineered nanobody. Nature. 2013 Oct 24; 502(7472):575-579.
Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. PMID: 24056936.
View in: PubMed Mentions: 114 Fields: Translation: HumansCells
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The role of ligands on the equilibria between functional states of a G protein-coupled receptor. J Am Chem Soc. 2013 Jun 26; 135(25):9465-74.
Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS. PMID: 23721409.
View in: PubMed Mentions: 58 Fields: Translation: HumansCells
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Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 2013 May 02; 497(7447):137-41.
Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ. PMID: 23604254.
View in: PubMed Mentions: 135 Fields: Translation: HumansAnimalsCells
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Corrigendum: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. Chemistry - A European Journal. 2013 Apr 15; 19(16):4964-4964.
Pil Seok Chae, Søren G. F. Rasmussen, Rohini R. Rana, Kamil Gotfryd, Andrew C. Kruse, Aashish Manglik, Kyung Ho Cho, Shailika Nurva, Ulrik Gether, Lan Guan, Claus J. Loland, Bernadette Byrne, Brian K. Kobilka, Samuel H. Gellman. .
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Crystal structure of active Beta-arrestin1 bound to phosphorylated carboxy-terminus of a G protein-coupled receptor. The FASEB Journal. 2013 Apr 1; 27:lb549-lb549.
Arun K. Shukla, Aashish Manglik, Andrew Kruse, Rosana Reis, Wei Chou Tseng, Dean P. Staus, Daniel Hilger, Serdar Uysal, LiYin Huang, Marcin Peduch, Prachi Tripathi-Shukla, Akiko Koide, Shohei Koide, William I. Weis, Anthony K. Kossiakoff, Brian K. Kobilka, Robert J. Lefkowitz. .
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The dynamic process of ß(2)-adrenergic receptor activation. Cell. 2013 Jan 31; 152(3):532-42.
Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. PMID: 23374348.
View in: PubMed Mentions: 260 Fields: Translation: HumansCells
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Role of detergents in conformational exchange of a G protein-coupled receptor. J Biol Chem. 2012 Oct 19; 287(43):36305-11.
Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, Prosser RS. PMID: 22893704.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
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Inside Cover: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins (Chem. Eur. J. 31/2012). Chemistry - A European Journal. 2012 Jul 27; 18(31):9434-9434.
Pil Seok Chae, Søren G. F. Rasmussen, Rohini R. Rana, Kamil Gotfryd, Andrew C. Kruse, Aashish Manglik, Kyung Ho Cho, Shailika Nurva, Ulrik Gether, Lan Guan, Claus J. Loland, Bernadette Byrne, Brian K. Kobilka, Samuel H. Gellman. .
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A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry. 2012 Jul 27; 18(31):9485-90.
Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. PMID: 22730191.
View in: PubMed Mentions: 39 Fields: Translation: AnimalsCells
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Structure of the d-opioid receptor bound to naltrindole. Nature. 2012 May 16; 485(7398):400-4.
Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK. PMID: 22596164.
View in: PubMed Mentions: 229 Fields: Translation: AnimalsCells
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 Mar 21; 485(7398):321-6.
Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. PMID: 22437502.
View in: PubMed Mentions: 433 Fields: Translation: AnimalsCells
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Stably integrated luxCDABE for assessment of Salmonella invasion kinetics. Mol Imaging. 2008 Sep-Oct; 7(5):222-33.
Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. PMID: 19123992.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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Year | Publications |
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2008 | 1 | 2012 | 5 | 2013 | 8 | 2014 | 3 | 2015 | 8 | 2016 | 6 | 2017 | 1 | 2018 | 6 | 2019 | 2 | 2020 | 13 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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