Arielle Klepper, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address1700 4th Street, #404
San Francisco CA 94158
Phone415-885-7788
PronounsShe/Her/Hers
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    Icahn School of Medicine at Mount Sinai, New York, NYMD/PhD2016Medicine/Biology
    University of California, San FranciscoInternal Medicine Residency2019
    University of California, San FranciscoChief Residency2020
    University of California, San FranciscoFellowship, Gastroenterology2024
    Collapse awards and honors
    University of California, San Francisco2024  - 2027John A. Watson Faculty Scholars Award
    University of California, San Francisco2020  - 2025Diversity in Biomedical Sciences Award
    UCSF Liver Center2024  - 2025Pilot/Feasibility Award

    Collapse Overview 
    Collapse overview
    Dr. Arielle Klepper is a gastroenterologist and hepatologist. She received her MD and PhD from the Icahn School of Medicine at Mount Sinai, followed by internal medicine residency, chief residency, and gastroenterology fellowship at the University of California, San Francisco. Her clinical focus is in both gastroenterology and general hepatology, joining Drs. Courtney Sherman and Treveni Defries, as well as Davina Martinez, in the HALT clinic, focused on the treatment of patients with alcohol-associated liver disease. Her laboratory-based research focuses on the role of infection in the progression of liver disease. Her primary projects include 1) interrogating microbial and host cells present in ascites fluid using sequencing-based techniques and 2) investigating the role of human herpesviruses in autoimmune liver disease, such as autoimmune hepatitis.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. FRI-303 Immune profiling in autoimmune hepatitis identifies distinct patterns autoreactivity. Journal of Hepatology. 2025 May 1; 82:s294-s295. Klepper KA, Asaki AJ, Kung KA, Vazquez VS, Bodansky BA, Mitchell MA, Mann MS, Zorn ZK, Avila-Vargas AI, Kari KS, Tekeste TM, Castro CJ, Lee LB, Duarte DM, Khalili KM, Yang YM, Wolters WP, Price PJ, Weiler-Normann WC, Lohse LA, DeRisi DJ, Tana TM. .
      View in: Publisher Site   Mentions:
    2. FRI-303 Immune profiling in autoimmune hepatitis identifies distinct patterns autoreactivity. Journal of Hepatology. 2025 May 1; 82:s294-s295. Klepper KA, Asaki AJ, Kung KA, Vazquez VS, Bodansky BA, Mitchell MA, Mann MS, Zorn ZK, Avila-Vargas AI, Kari KS, Tekeste TM, Castro CJ, Lee LB, Duarte DM, Khalili KM, Yang YM, Wolters WP, Price PJ, Weiler-Normann WC, Lohse LA, DeRisi DJ, Tana TM. .
      View in: Publisher Site   Mentions:
    3. Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights. medRxiv. 2024 Oct 29. Klepper A, Asaki J, Kung AF, Vazquez SE, Bodansky A, Mitchell A, Mann SA, Zorn K, Avila-Vargas I, Kari S, Tekeste M, Castro J, Lee B, Duarte M, Khalili M, Yang M, Wolters P, Price J, Perito E, Feng S, Maher JJ, Lai JC, Weiler-Normann C, Lohse AW, DeRisi J, Tana M. PMID: 37398174; PMCID: PMC10312872.
      View in: PubMed   Mentions:
    4. AIH Therapy: Beyond First-Line. Current Hepatology Reports. 2024 Mar 8; 1-8. Adao AI, Klepper KA, Tana TM. .
      View in: Publisher Site   Mentions:
    5. EP1004: INCREASING REFERRALS TO GENETIC COUNSELING IN PATIENTS AT ELEVATED RISK FOR LYNCH SYNDROME. Gastroenterology. 2022 May 1; 162(7):s-1030-s-1031. Blaisdell BA, Hochstetler HL, Klepper KA, Feuille FC, Zhang ZB, Xu XC, Yu YA, Blanco BA, Terdiman TJ, Singh SA. .
      View in: Publisher Site   Mentions:
    6. Transcriptomic profiling of blood from autoimmune hepatitis patients reveals potential mechanisms with implications for management. PLoS One. 2022; 17(3):e0264307. Tana MM, Klepper A, Lyden A, Pisco AO, Phelps M, McGee B, Green K, Feng S, DeRisi J, Crawford ED, Lammert CS. PMID: 35312680; PMCID: PMC8936448.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. S305 Improving Identification of Patients Meeting Lynch Syndrome Testing Criteria in Endoscopy. The American Journal of Gastroenterology. 2021 Oct 1; 116:s133-s134. Blaisdell BA, Hochstetler HL, Klepper KA, Feuille FC, Zhang ZB, Blanco BA, Terdiman TJ, Singh SA. .
      View in: Publisher Site   Mentions:
    8. A subset of liver resident natural killer cells is expanded in hepatitis C-infected patients with better liver function. Sci Rep. 2021 01 15; 11(1):1551. Doyle EH, Aloman C, El-Shamy A, Eng F, Rahman A, Klepper AL, Haydel B, Florman SS, Fiel MI, Schiano T, Branch AD. PMID: 33452360; PMCID: PMC7810844.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. Individual liver plasmacytoid dendritic cells are capable of producing IFNα and multiple additional cytokines during chronic HCV infection. PLoS Pathog. 2019 07; 15(7):e1007935. Doyle EH, Rahman A, Aloman C, Klepper AL, El-Shamy A, Eng F, Rocha C, Kim S, Haydel B, Florman SS, Fiel MI, Schiano T, Branch AD. PMID: 31356648; PMCID: PMC6687199.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    10. Newly discovered hepatitis C virus minicores circulate in human blood. Hepatol Commun. 2018 01; 2(1):21-28. Eng FJ, El-Shamy A, Doyle EH, Klepper A, Muerhoff AS, Branch AD. PMID: 29404509; PMCID: PMC5776872.
      View in: PubMed   Mentions: 1     Fields:    
    11. Hepatitis C virus double-stranded RNA is the predominant form in human liver and in interferon-treated cells. Hepatology. 2017 08; 66(2):357-370. Klepper A, Eng FJ, Doyle EH, El-Shamy A, Rahman AH, Fiel MI, Avino GC, Lee M, Ye F, Roayaie S, Bansal MB, MacDonald MR, Schiano TD, Branch AD. PMID: 27642141; PMCID: PMC5573989.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. A cell culture system for distinguishing hepatitis C viruses with and without liver cancer-related mutations in the viral core gene. J Hepatol. 2015 Dec; 63(6):1323-33. El-Shamy A, Eng FJ, Doyle EH, Klepper AL, Sun X, Sangiovanni A, Iavarone M, Colombo M, Schwartz RE, Hoshida Y, Branch AD. PMID: 26220749; PMCID: PMC4654634.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. Macrophages and the Viral Dissemination Super Highway. EC Microbiol. 2015; 2(3):328-336. Klepper A, Branch AD. PMID: 26949751; PMCID: PMC4774560.
      View in: PubMed   Mentions: 12  
    14. High mobility group box-1 (HMGB1) participates in the pathogenesis of alcoholic liver disease (ALD). J Biol Chem. 2014 Aug 15; 289(33):22672-22691. Ge X, Antoine DJ, Lu Y, Arriazu E, Leung TM, Klepper AL, Branch AD, Fiel MI, Nieto N. PMID: 24928512; PMCID: PMC4132775.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    15. Building failure into successful team science: highlights of the second SINAInnovations event. Dis Model Mech. 2014 Mar; 7(3):311-2. Klepper A, Pendleton M. PMID: 24609031; PMCID: PMC3944490.
      View in: PubMed   Mentions: 1     Fields:    
    16. Sa1965 Hepatitis C Virus (HCV) Double-Stranded RNA is Abundant and May Be an Important Viral Reservoir in Persistence and Relapse. Gastroenterology. 2012 May 1; 142(5):s-968. Klepper KA, Eng EF, Dieterich DJ, Walewski WJ, Gutierrez GJ, Schwartz SM, Fierer FD, Schiano ST, Branch BA. .
      View in: Publisher Site   Mentions:
    17. Cross-genotypic polyclonal anti-HCV antibodies from human ascitic fluid. J Virol Methods. 2011 Jan; 171(1):169-75. Gutierrez JA, Klepper AL, Garber J, Walewski JL, Bateman K, Khaitova V, Syder A, Tscherne DM, Gauthier A, Jefferson D, Rice CM, Schiano TD, Branch AD. PMID: 21034775; PMCID: PMC3018694.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates. J Acquir Immune Defic Syndr. 2010 Mar; 53(3):292-302. Chang TL, Klepper A, Ding J, Garber J, Rapista A, Mosoian A, Hubner W, Gutierrez J, Walewski J, Abergel J, Schiano T, Branch A. PMID: 20065862; PMCID: PMC2840202.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Internal initiation stimulates production of p8 minicore, a member of a newly discovered family of hepatitis C virus core protein isoforms. J Virol. 2009 Apr; 83(7):3104-14. Eng FJ, Walewski JL, Klepper AL, Fishman SL, Desai SM, McMullan LK, Evans MJ, Rice CM, Branch AD. PMID: 19129450; PMCID: PMC2655593.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    20. Liver fibrosis during an outbreak of acute hepatitis C virus infection in HIV-infected men: a prospective cohort study. J Infect Dis. 2008 Sep 01; 198(5):683-6. Fierer DS, Uriel AJ, Carriero DC, Klepper A, Dieterich DT, Mullen MP, Thung SN, Fiel MI, Branch AD. PMID: 18627270; PMCID: PMC4520699.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansPHPublic Health
    21. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology. 2006 Sep; 131(3):862-77. Fukata M, Chen A, Klepper A, Krishnareddy S, Vamadevan AS, Thomas LS, Xu R, Inoue H, Arditi M, Dannenberg AJ, Abreu MT. PMID: 16952555; PMCID: PMC2169292.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    Arielle's Networks
    Concepts (121)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (12)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSF Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).

    We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use. This site is running Profiles RNS version UCSF-v3.1.0-12-gbedcc43d on PROFILES-PWEB04.

    Copyright © The Regents of the University of California.