Dr. Arielle Klepper is a gastroenterologist, hepatologist, and physician-scientist whose clinical and research interests focus on chronic liver disease and human immunology. She received her MD and PhD from the Icahn School of Medicine at Mount Sinai, followed by internal medicine residency, chief residency, and gastroenterology fellowship at the University of California, San Francisco. Her clinical practice spans gastroenterology and hepatology, with a particular focus on alcohol-associated liver disease. She cares for patients in the HALT Clinic, a multidisciplinary program dedicated to the management and treatment of alcohol-associated liver disease.

Dr. Klepper's research seeks to understand why immune responses to pathogens sometimes fail to provide effective protection and instead contribute to disease. Her laboratory studies liver disease to understand the mechanisms that shape antigen-specific humoral immunity, integrating high-resolution antigen discovery with immune profiling, B-cell receptor analysis, and functional antibody studies. Her current work focuses on host-microbial interactions in cirrhosis, where she studies how microbial exposure, B-cell differentiation, and antibody responses contribute to immune dysfunction and adverse outcomes. She established the Ascites Characterization and Evaluation Study (ACES) to investigate these processes directly within the human peritoneal compartment. Her work also uses proteome-wide phage display to investigate antiviral and autoreactive antibody responses in autoimmune liver disease. Together, these studies aim to define the mechanisms that distinguish protective, ineffective, and pathogenic humoral immune responses in human disease.