Dr. Wolters received in his M.D. degree from the University of Minnesota; trained in internal medicine at the University of Colorado, and pulmonary and critical care medicine at the University of California, San Francisco where he joined the division of pulmonary and critical care medicine in 1999. His primary clinical interest is caring for patients with interstitial lung diseases.
The goal of my research program is to understand the molecular pathogenesis of fibrotic lung disease and to use this knowledge to develop novel therapies for treating these diseases. My research group investigates lung fibrosis by applying animal models and translational studies using patient samples to define the cellular and molecular mechanisms that promote lung fibrosis. To achieve this goal, we have established a large repository of biological specimens, obtained from generous patients with interstitial lung diseases, and methods for isolating pure populations of alveolar type II cells from fibrotic lungs that can be used to investigate mechanisms of disease pathogenesis. Our recent scientific focus has been on explaining the role epithelial cells play in promoting lung fibrosis with an emphasis on the roles of the unfolded protein response and aging.