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Paul Wolters, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-514-2601
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Wolters received in his M.D. degree from the University of Minnesota in 1992; trained in internal medicine at the University of Colorado, and pulmonary and critical care medicine at the University of California, San Francisco. He joined the division of pulmonary and critical care medicine in 1999. His primary clinical interest is caring for patients with interstitial lung diseases.

    Research Interests
    The goal of my research program is to understand the molecular pathogenesis of fibrotic lung disease and to use this knowledge to develop novel therapies for treating these diseases. My research group investigates lung fibrosis by applying animal models and translational studies using patient samples to define the cellular and molecular mechanisms that promote lung fibrosis. To achieve this goal, we have established a large repository of biological specimens, obtained from generous patients with interstitial lung diseases, and methods for isolating pure populations of alveolar type II cells from fibrotic lungs that can be used to investigate mechanisms of disease pathogenesis. Our recent scientific focus has been on explaining the role epithelial cells play in promoting lung fibrosis with an emphasis on the roles of the unfolded protein response and aging.


    Collapse Research 
    Collapse Research Activities and Funding
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH/NHLBI P01HL108794Aug 9, 2012 - Jul 31, 2017
    Role: Co-Investigator
    Analysis of Alveolar Type II cells in Normal and Fibrotic Human Lung
    NIH/NHLBI R21HL104422Apr 1, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Mast Cells and the Host Response in the Lung
    NIH/NHLBI R01HL075026Jul 2, 2004 - Jun 30, 2009
    Role: Principal Investigator
    MAST CELL CYSTEINE PROTEASES IN LUNG INFLAMMATION
    NIH/NHLBI K08HL004055Aug 4, 1999 - Jul 31, 2004
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ley B, Newton CA, Arnould I, Elicker BM, Henry TS, Vittinghoff E, Golden JA, Jones KD, Batra K, Torrealba J, Garcia CK, Wolters P. The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study. Lancet Respir Med. 2017 Jun 22. PMID: 28648751.
      View in: PubMed
    2. Morisset J, Vittinghoff E, Elicker BM, Hu X, Le S, Ryu JH, Jones KD, Haemel A, Golden JA, Boin F, Ley B, Wolters P, King TE, Collard HR, Lee JS. Mortality risk prediction in scleroderma-related interstitial lung disease: the SADL model. Chest. 2017 Jun 16. PMID: 28629914.
      View in: PubMed
    3. Wolters P. A recurring theme in pulmonary fibrosis genetics. Eur Respir J. 2017 May; 49(5). PMID: 28495682.
      View in: PubMed
    4. Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters P, Greenland JR. Short lung transplant donor telomere length is associated with decreased CLAD-free survival. Thorax. 2017 Apr 26. PMID: 28446663.
      View in: PubMed
    5. Morisset J, Vittinghoff E, Lee BY, Tonelli R, Hu X, Elicker BM, Ryu JH, Jones KD, Cerri S, Manfredi A, Sebastiani M, Gross AJ, Ley B, Wolters P, King TE, Kim DS, Collard HR, Lee JS. The performance of the GAP model in patients with rheumatoid arthritis associated interstitial lung disease. Respir Med. 2017 Jun; 127:51-56. PMID: 28502419.
      View in: PubMed
    6. Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters P, Erle DJ, Locksley RM. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017 Apr 20; 169(3):497-509.e13. PMID: 28431248.
      View in: PubMed
    7. Jia G, Chandriani S, Abbas AR, DePianto DJ, N'Diaye EN, Yaylaoglu MB, Moore HM, Peng I, DeVoss J, Collard HR, Wolters P, Egen JG, Arron JR. CXCL14 is a candidate biomarker for Hedgehog signalling in idiopathic pulmonary fibrosis. Thorax. 2017 Mar 01. PMID: 28250200.
      View in: PubMed
    8. Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters P, Collard HR, Koth LL. Pathological Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis. Chest. 2017 Feb 18. PMID: 28223152.
      View in: PubMed
    9. Brownell R, Moua T, Henry TS, Elicker BM, White D, Vittinghoff E, Jones KD, Urisman A, Aravena C, Johannson KA, Golden JA, King TE, Wolters P, Collard HR, Ley B. The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia. Thorax. 2017 Jan 12. PMID: 28082530.
      View in: PubMed
    10. Lofgren S, Hinchcliff M, Carns M, Wood T, Aren K, Arroyo E, Cheung P, Kuo A, Valenzuela A, Haemel A, Wolters P, Gordon J, Spiera R, Assassi S, Boin F, Chung L, Fiorentino D, Utz PJ, Whitfield ML, Khatri P. Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity. JCI Insight. 2016 Dec 22; 1(21):e89073. PMID: 28018971.
      View in: PubMed
    11. Morisset J, Johannson KA, Vittinghoff E, Aravena C, Elicker BM, Jones KD, Fell CD, Manganas H, Dubé BP, Wolters P, Collard HR, Ryerson CJ, Ley B. Use of mycophenolate mofetil or azathioprine for the management of chronic hypersensitivity pneumonitis. Chest. 2016 Nov 2. PMID: 27816444.
      View in: PubMed
    12. Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters P. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI Insight. 2016 Sep 08; 1(14):e86704. PMID: 27699234.
      View in: PubMed
    13. Tatler AL, Goodwin AT, Gbolahan O, Saini G, Porte J, John AE, Clifford RL, Violette SM, Weinreb PH, Parfrey H, Wolters P, Gauldie J, Kolb M, Jenkins G. Amplification of TGFß Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis. PLoS One. 2016; 11(8):e0158047. PMID: 27494713.
      View in: PubMed
    14. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters P. miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016; 11(6):e0158367. PMID: 27362652.
      View in: PubMed
    15. Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch DA, Groshong S, Collard HR, Wolters P, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Murphy E, Smith K, McKean D, Pedersen BS, Talbert J, Powers J, Markin CR, Beckman KB, Lathrop M, Freed B, Langefeld CD, Schwartz DA. Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genet. 2016; 17(1):74. PMID: 27266705.
      View in: PubMed
    16. Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Wolters P, Collard HR, et al. A diagnostic model for chronic hypersensitivity pneumonitis. Thorax. 2016 May 31. PMID: 27245779.
      View in: PubMed
    17. Mak AC, Tang PL, Cleveland C, Smith MH, Connolly MK, Katsumoto TR, Wolters P, Kwok PY, Criswell LA, et al. Whole Exome Sequencing for Identification of Potential Causal Variants for Diffuse Cutaneous Systemic Sclerosis. Arthritis Rheumatol. 2016 Apr 25. PMID: 27111861.
      View in: PubMed
    18. Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters P, Caughey GH, Tang Q. Donor-Reactive Regulatory T-Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Transplantation. 2016 Apr 13. PMID: 27077597.
      View in: PubMed
    19. Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, Kerama-Likoko C, Violette SM, Weinreb PH, Knox AJ, Laurent G, Parfrey H, Wolters P, Wallace W, Alberti S, Nordheim A, Jenkins G. Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin avß6 Expression. J Biol Chem. 2016 Apr 29; 291(18):9540-53. PMID: 26861876.
      View in: PubMed
    20. Withana NP, Ma X, McGuire HM, Verdoes M, van der Linden WA, Ofori LO, Zhang R, Li H, Sanman LE, Wei K, Yao S, Wu P, Li F, Huang H, Xu Z, Wolters P, Rosen GD, Collard HR, Zhu Z, Cheng Z, Bogyo M. Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes. Sci Rep. 2016; 6:19755. PMID: 26797565.
      View in: PubMed
    21. Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters P, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal NP, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ. Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation. Am J Respir Crit Care Med. 2015 Dec 1; 192(11):1325-34. PMID: 26258797.
      View in: PubMed
    22. Disayabutr S, Calfee CS, Collard HR, Wolters P. Interstitial lung diseases in the hospitalized patient. BMC Med. 2015; 13:245. PMID: 26407727; PMCID: PMC4584017.
    23. Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum AK, Wolters P, Collard HR, Lee JS. Survival in interstitial pneumonia with features of autoimmune disease: A comparison of proposed criteria. Respir Med. 2015 Oct; 109(10):1326-31. PMID: 26303338.
      View in: PubMed
    24. Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum AK, Wolters P, Ryu JH, Collard HR. The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis. Respir Med. 2015 Aug; 109(8):1058-62. PMID: 26140806; PMCID: PMC4522344 [Available on 08/01/16].
    25. Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD. Lung transplantation for hypersensitivity pneumonitis. Chest. 2015 Jun; 147(6):1558-65. PMID: 25412059; PMCID: PMC4451710 [Available on 06/01/16].
    26. Kim SY, Diggans J, Pankratz D, Huang J, Pagan M, Sindy N, Tom E, Anderson J, Choi Y, Lynch DA, Steele MP, Flaherty KR, Brown KK, Farah H, Bukstein MJ, Pardo A, Selman M, Wolters P, Nathan SD, Colby TV, Myers JL, Katzenstein AL, Raghu G, Kennedy GC. Classification of usual interstitial pneumonia in patients with interstitial lung disease: assessment of a machine learning approach using high-dimensional transcriptional data. Lancet Respir Med. 2015 Jun; 3(6):473-82. PMID: 26003389.
      View in: PubMed
    27. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL. Transforming Growth Factor-ß and Interleukin-1ß Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem. 2015 Jun 5; 290(23):14717-28. PMID: 25918170; PMCID: PMC4505537 [Available on 06/05/16].
    28. Yang J, Velikoff M, Agarwal M, Disayabutr S, Wolters P, Kim KK. Overexpression of inhibitor of DNA-binding 2 attenuates pulmonary fibrosis through regulation of c-Abl and Twist. Am J Pathol. 2015 Apr; 185(4):1001-11. PMID: 25661109; PMCID: PMC4380847 [Available on 04/01/16].
    29. Wolters P, Elicker BM. Subacute onset of pulmonary langerhans cell histiocytosis with resolution after smoking cessation. Am J Respir Crit Care Med. 2014 Dec 1; 190(11):e64. PMID: 25436789.
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    30. Jaffar J, Unger S, Corte TJ, Keller M, Wolters P, Richeldi L, Cerri S, Prêle CM, Hansbro PM, Argraves WS, Oliver RA, Oliver BG, Black JL, Burgess JK. Fibulin-1 predicts disease progression in patients with idiopathic pulmonary fibrosis. Chest. 2014 Oct; 146(4):1055-63. PMID: 24832167; PMCID: PMC4188142.
    31. DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters P, Arron JR. Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax. 2015 Jan; 70(1):48-56. PMID: 25217476; PMCID: PMC4472447 [Available on 01/01/16].
    32. Sutherland RE, Barry SS, Olsen JS, Salantes DB, Caughey GH, Wolters P. Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):818-23. PMID: 24955853; PMCID: PMC4107110.
    33. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. PMID: 24944194; PMCID: PMC4341974.
    34. Stuart BD, Lee JS, Kozlitina J, Noth I, Devine MS, Glazer CS, Torres F, Kaza V, Girod CE, Jones KD, Elicker BM, Ma SF, Vij R, Collard HR, Wolters P, Garcia CK. Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation. Lancet Respir Med. 2014 Jul; 2(7):557-65. PMID: 24948432; PMCID: PMC4136521.
    35. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters P, Woodruff PG, Fahy JV, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084. PMID: 24915147; PMCID: PMC4051692.
    36. Chandriani S, DePianto DJ, N'Diaye EN, Abbas AR, Jackman J, Bevers J, Ramirez-Carrozzi V, Pappu R, Kauder SE, Toy K, Ha C, Modrusan Z, Wu LC, Collard HR, Wolters P, Egen JG, Arron JR. Endogenously expressed IL-13Ra2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts. J Immunol. 2014 Jul 1; 193(1):111-9. PMID: 24879793.
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    37. Johannson KA, de Boer K, Wolters P, Golden JA, Lee JS, Collard HR. Diagnosis of idiopathic pulmonary fibrosis with high-resolution CT. Lancet Respir Med. 2014 May; 2(5):e5. PMID: 24815808.
      View in: PubMed
    38. Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters P, Koth LL, King TE, Collard HR. Predicting survival across chronic interstitial lung disease: the ILD-GAP model. Chest. 2014 Apr; 145(4):723-8. PMID: 24114524.
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    39. Greer AM, Wu N, Putnam AL, Woodruff PG, Wolters P, Kinet JP, Shin JS. Serum IgE clearance is facilitated by human FceRI internalization. J Clin Invest. 2014 Mar; 124(3):1187-98. PMID: 24569373; PMCID: PMC3938266.
    40. Tang CH, Seeley EJ, Huang X, Wolters P, Liu L. Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice. Biochem Biophys Res Commun. 2013 Dec 6; 442(1-2):122-6. PMID: 24239886; PMCID: PMC3885541.
    41. Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters P, Chapman HA, Kämpe O, Anderson MS. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Transl Med. 2013 Oct 9; 5(206):206ra139. PMID: 24107778; PMCID: PMC3882146.
    42. Wolters P, Collard HR, Jones KD. Pathogenesis of idiopathic pulmonary fibrosis. Annu Rev Pathol. 2014; 9:157-79. PMID: 24050627; PMCID: PMC4116429.
    43. Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters P, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet. 2013 Jun; 45(6):613-20. PMID: 23583980; PMCID: PMC3677861.
    44. Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters P. Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice. J Immunol. 2013 May 1; 190(9):4717-24. PMID: 23543756; PMCID: PMC3973442.
    45. Ryerson CJ, Urbania TH, Richeldi L, Mooney JJ, Lee JS, Jones KD, Elicker BM, Koth LL, King TE, Wolters P, Collard HR. Prevalence and prognosis of unclassifiable interstitial lung disease. Eur Respir J. 2013 Sep; 42(3):750-7. PMID: 23222877.
      View in: PubMed
    46. Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum AK, Wolters P, Cerri S, Richeldi L, Jones KD, King TE, Collard HR. Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis. Respir Med. 2013 Feb; 107(2):249-55. PMID: 23186614; PMCID: PMC3543473.
    47. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters P. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res. 2012; 13:105. PMID: 23167970; PMCID: PMC3547729.
    48. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters P, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):16354-9. PMID: 22988107; PMCID: PMC3479591.
    49. Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters P, Shokat KM, Huang X, Sheppard D. Integrin a9ß1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest. 2012 Aug; 122(8):2916-27. PMID: 22772469; PMCID: PMC3448403.
    50. Seeley EJ, Matthay MA, Wolters P. Inflection points in sepsis biology: from local defense to systemic organ injury. Am J Physiol Lung Cell Mol Physiol. 2012 Sep; 303(5):L355-63. PMID: 22707617; PMCID: PMC3468422.
    51. Richeldi L, Ryerson CJ, Lee JS, Wolters P, Koth LL, Ley B, Elicker BM, Jones KD, King TE, Ryu JH, Collard HR. Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis. Thorax. 2012 May; 67(5):407-11. PMID: 22426899.
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    52. Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters P. Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis. Histopathology. 2012 Jul; 61(1):98-106. PMID: 22394225; PMCID: PMC3371307.
    53. Lee JS, Song JW, Wolters P, Elicker BM, King TE, Kim DS, Collard HR. Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis. Eur Respir J. 2012 Feb; 39(2):352-8. PMID: 22183478.
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    54. Sutherland RE, Xu X, Kim SS, Seeley EJ, Caughey GH, Wolters P. Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice. PLoS One. 2011; 6(11):e27564. PMID: 22110673; PMCID: PMC3217977.
    55. Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters P, Nishimura SL. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. J Biol Chem. 2011 Oct 21; 286(42):36864-74. PMID: 21878622; PMCID: PMC3196125.
    56. Lee JS, Ryu JH, Elicker BM, Lydell CP, Jones KD, Wolters P, King TE, Collard HR. Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1390-4. PMID: 21700909; PMCID: PMC3262030.
    57. Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, Millar A, Parfrey H, Scotton C, Tetley T, Thickett D, Wolters P. In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax. 2012 Feb; 67(2):179-82. PMID: 21680569.
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    58. Seeley EJ, Sutherland RE, Kim SS, Wolters P. Systemic mast cell degranulation increases mortality during polymicrobial septic peritonitis in mice. J Leukoc Biol. 2011 Sep; 90(3):591-7. PMID: 21653231; PMCID: PMC3157900.
    59. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß. J Clin Invest. 2011 Jul; 121(7):2863-75. PMID: 21646718; PMCID: PMC3223836.
    60. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters P. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L71-8. PMID: 21498628; PMCID: PMC3129898.
    61. Wootton SC, Kim DS, Kondoh Y, Chen E, Lee JS, Song JW, Huh JW, Taniguchi H, Chiu C, Boushey H, Lancaster LH, Wolters P, DeRisi J, Ganem D, Collard HR. Viral infection in acute exacerbation of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1698-702. PMID: 21471095; PMCID: PMC3136996.
    62. Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters P, Nishimura SL. Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway. J Biol Chem. 2010 Aug 6; 285(32):24695-706. PMID: 20519498; PMCID: PMC2915706.
    63. Collard HR, Calfee CS, Wolters P, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L3-7. PMID: 20418386; PMCID: PMC2904092.
    64. Kinder BW, Shariat C, Collard HR, Koth LL, Wolters P, Golden JA, Panos RJ, King TE. Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. Lung. 2010 Apr; 188(2):143-9. PMID: 20069430; PMCID: PMC2837880.
    65. Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest. 2009 Dec; 119(12):3713-22. PMID: 19884654; PMCID: PMC2786804.
    66. Wolters P. Could N-acetylcysteine slow progression of idiopathic pulmonary fibrosis by inhibiting EMT? Am J Physiol Lung Cell Mol Physiol. 2009 Nov; 297(5):L803-4. PMID: 19700642.
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    67. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters P, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5. PMID: 19633655; PMCID: PMC2736875.
    68. Wolters P, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank JA. Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. J Immunol. 2009 Jun 15; 182(12):8056-62. PMID: 19494331; PMCID: PMC2737530.
    69. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters P, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. PMID: 19104148.
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    70. Sutherland RE, Olsen JS, McKinstry A, Villalta SA, Wolters P. Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing. J Immunol. 2008 Oct 15; 181(8):5598-605. PMID: 18832718; PMCID: PMC2610024.
    71. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. PMID: 17965775; PMCID: PMC2040320.
    72. Sun J, Sukhova GK, Yang M, Wolters P, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest. 2007 Nov; 117(11):3359-68. PMID: 17932568; PMCID: PMC2000808.
    73. Zamora AC, Wolters P, Collard HR, Connolly MK, Elicker BM, Webb WR, King TE, Golden JA. Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease. Respir Med. 2008 Jan; 102(1):150-5. PMID: 17822892.
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    74. Pottier N, Chupin C, Defamie V, Cardinaud B, Sutherland R, Rios G, Gauthier F, Wolters P, Berthiaume Y, Barbry P, Mari B. Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3? Am J Respir Crit Care Med. 2007 Dec 1; 176(11):1098-107. PMID: 17673693.
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    75. Kinder BW, Collard HR, Koth L, Daikh DI, Wolters P, Elicker B, Jones KD, King TE. Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? Am J Respir Crit Care Med. 2007 Oct 1; 176(7):691-7. PMID: 17556720; PMCID: PMC1994238.
    76. Sun J, Sukhova GK, Wolters P, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007 Jun; 13(6):719-24. PMID: 17546038.
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    77. Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters P, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF. Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology. 2007 Jun; 132(7):2422-37. PMID: 17570216; PMCID: PMC2366898.
    78. Calfee CS, Shah SJ, Wolters P, Saint S, King TE. Clinical problem-solving. Anchors away. N Engl J Med. 2007 Feb 1; 356(5):504-9. PMID: 17267911.
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    79. Xu X, Zhang D, Zhang H, Wolters P, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17. PMID: 17158962; PMCID: PMC2118183.
    80. Wang B, Huang X, Wolters P, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP. Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol. 2006 Nov 1; 177(9):5779-84. PMID: 17056501.
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    81. Kim KK, Kugler MC, Wolters P, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13180-5. PMID: 16924102; PMCID: PMC1551904.
    82. Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters P. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol Chem. 2006 Aug; 387(8):1143-6. PMID: 16895486; PMCID: PMC2271110.
    83. Zamora AC, Collard HR, Wolters P, Webb WR, King TE. Neurofibromatosis-associated lung disease: a case series and literature review. Eur Respir J. 2007 Jan; 29(1):210-4. PMID: 16870664.
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    84. Xu X, Zhang D, Lyubynska N, Wolters P, Killeen NP, Baluk P, McDonald DM, Hawgood S, Caughey GH. Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med. 2006 Jan 15; 173(2):219-25. PMID: 16210667; PMCID: PMC2662990.
    85. Edwards ST, Cruz AC, Donnelly S, Dazin PF, Schulman ES, Jones KD, Wolters P, Hoopes C, Dolganov GM, Fang KC. c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases. J Pathol. 2005 Jul; 206(3):279-90. PMID: 15887294.
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    86. Wolters P, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice. Clin Exp Allergy. 2005 Jan; 35(1):82-8. PMID: 15649271; PMCID: PMC2271075.
    87. Mallen-St Clair J, Pham CT, Villalta SA, Caughey GH, Wolters P. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest. 2004 Feb; 113(4):628-34. PMID: 14966572; PMCID: PMC338261.
    88. Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem. 2003 Oct-Nov; 384(10-11):1527-31. PMID: 14669996.
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    89. Bhagwandin VJ, Hau LW, Mallen-St Clair J, Wolters P, Caughey GH. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. J Biol Chem. 2003 Jan 31; 278(5):3363-71. PMID: 12441343.
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    90. Muilenburg DJ, Raymond WW, Wolters P, Caughey GH. Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase. Biochim Biophys Acta. 2002 Apr 29; 1596(2):346-56. PMID: 12007614.
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    91. Wolters P, Pham CT, Muilenburg DJ, Ley TJ, Caughey GH. Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice. J Biol Chem. 2001 May 25; 276(21):18551-6. PMID: 11279033.
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    92. Wolters P, Chapman HA. Importance of lysosomal cysteine proteases in lung disease. Respir Res. 2000; 1(3):170-7. PMID: 11667982; PMCID: PMC59556.
    93. Caughey GH, Raymond WW, Wolters P. Angiotensin II generation by mast cell alpha- and beta-chymases. Biochim Biophys Acta. 2000 Jul 14; 1480(1-2):245-57. PMID: 10899625.
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    94. Caughey GH, Raymond WW, Blount JL, Hau LW, Pallaoro M, Wolters P, Verghese GM. Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. J Immunol. 2000 Jun 15; 164(12):6566-75. PMID: 10843716.
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    95. Wolters P, Laig-Webster M, Caughey GH. Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways. Am J Respir Cell Mol Biol. 2000 Feb; 22(2):183-90. PMID: 10657939.
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    96. Fang KC, Wolters P, Steinhoff M, Bidgol A, Blount JL, Caughey GH. Mast cell expression of gelatinases A and B is regulated by kit ligand and TGF-beta. J Immunol. 1999 May 1; 162(9):5528-35. PMID: 10228034.
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    97. Wolters P, Raymond WW, Blount JL, Caughey GH. Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I. J Biol Chem. 1998 Jun 19; 273(25):15514-20. PMID: 9624139.
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    98. Moss H, Bose S, Wolters P, Brouwers P. A preliminary study of factors associated with psychological adjustment and disease course in school-age children infected with the human immunodeficiency virus. J Dev Behav Pediatr. 1998 Feb; 19(1):18-25. PMID: 9524301.
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    99. Wolters P, Hildebrandt KM, Dickie JP, Anderson JS. Polymer length of teichuronic acid released from cell walls of Micrococcus luteus. J Bacteriol. 1990 Sep; 172(9):5154-9. PMID: 2394683; PMCID: PMC213175.
    100. O'Grady SM, Wolters P. Evidence for chloride secretion in the intestine of the winter flounder. Am J Physiol. 1990 Feb; 258(2 Pt 1):C243-7. PMID: 2305867.
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    101. O'Grady SM, Wolters P. Cardiac antisecretory peptide inhibits intestinal chloride secretion. Am J Physiol. 1989 Oct; 257(4 Pt 1):C775-80. PMID: 2801925.
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    102. O'Grady SM, Wolters P, Hildebrand K, Brown DR. Regulation of ion transport in porcine gallbladder: effects of VIP and norepinephrine. Am J Physiol. 1989 Jul; 257(1 Pt 1):C52-7. PMID: 2546435.
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    103. O'Grady SM, Wolters P. Sodium and chloride transport across the isolated porcine gallbladder. Am J Physiol. 1989 Jul; 257(1 Pt 1):C45-51. PMID: 2750890.
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