Jennifer Lai, MD

TitleAssistant Professor
SchoolUCSF School of Medicine
Address513 Parnassus Ave, Med Sci
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityB.S.2000
    Tufts University School of MedicineM.D./M.B.A.2005School of Medicine
    Columbia University Medical CenterInternship/Residency2008Department of Medicine
    UCSFAdvanced Training in Clinical Research2010
    UCSFFellowship in Gastroenterology2011
    UCSFFellowship in Advanced/Transplant Hepatology2012
    Collapse Awards and Honors
    American Society of Transplantation2016Clinical Science Career Development Award
    American Society of Transplantation2016  - 2017AST/Novartis Faculty Development Award (grant)
    American Geriatrics Society2015New Investigator Award
    International Liver Transplantation Society2015Young Investigator Award
    American Federation for Aging Research2014  - 2019Paul B. Beeson Scholar in Aging Research (grant)
    UCSF Pepper Center2014  - 2015Associate Scholar Genius Award (grant)
    UCSF Pepper Center2013  - 2014Pilot Award in Aging Research (grant)
    Association of Specialty Professors2013  - 2015T. Franklin Williams Scholar (grant)
    UCSF Liver Center2013  - 2014Pilot/Feasibility Award (grant)
    UCSF Resource Allocation Program2013  - 2014Pilot for Junior Investigator Award (grant)
    American College of Gastroenterology2012  - 2015Junior Faculty Career Development Award (grant)
    American College of Physicians2012  - currFellow
    American College of Gastrenterology2011  - 2012Clinical Research Award (grant)
    American Association for the Study of Liver Diseases2011  - 2012Transplant Hepatology Fellowship (grant)
    International Liver Transplantation Society2011Vanguard Award
    Northern California Kaiser Permanente2009  - 2010Sylvia Allison Kaplan Clinical Research Award (grant)
    Tufts University School of Medicine2005Alpha Omega Alpha

    Collapse Overview 
    Collapse Overview
    Dr. Lai is a general and transplant hepatologist who specializes in caring for patients with chronic viral hepatitis, autoimmune disorders, and cirrhosis, particularly those awaiting liver transplantation.

    Her academic mission is to improve the lives of patients with end-stage liver disease through the application of core principles of geriatrics into the care of patients with cirrhosis. Examples of these principles include assessing and reversing physical frailty, reducing polypharmacy, and integrating palliative care into liver transplantation. She is principal investigator of the NIH-funded Functional Assessment in Liver Transplantation (FrAILT) Study, which is actively enrolling patients with end-stage liver disease awaiting liver transplantation for assessments of physical frailty both before and after liver transplantation.

    After earning her undergraduate degree from Stanford University and combined MD/MBA degrees from Tufts University, she completed residency at the New York Presbyterian Hospital-Columbia and gastroenterology and advanced/transplant hepatology fellowships at UCSF. She is a member of the American Association for the Study of Liver Diseases, American Society of Transplantation, American Gastroenterological Association, American College of Gastroenterology, and International Liver Transplantation Society. She has been recognized as a Fellow of the American College of Physicians (FACP). She serves as Associate Editor for the American Journal of Transplantation, Transplantation,and is a member for the Editorial Board for Liver Transplantation.

    Collapse Research 
    Collapse Research Activities and Funding
    Frailty and Functional Status in Older Liver Transplant Patients
    NIH/NIA K23AG048337Sep 15, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Global Functional Status in the Older Liver Transplant Candidate
    NIH/NIA R03AG045072Aug 15, 2013 - Jul 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Clinical Trials
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Spengler EK, O'Leary JG, Te HS, Rogal S, Pillai AA, Al-Osaimi A, Desai A, Fleming JN, Ganger D, Seetharam A, Tsoulfas G, Montenovo M, Lai J. Liver Transplantation in the Obese Cirrhotic Patient. Transplantation. 2017 Oct; 101(10):2288-2296. PMID: 28930104.
      View in: PubMed
    2. Lai J, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, Feng S. Development of a novel frailty index to predict mortality in patients with end-stage liver disease. Hepatology. 2017 Aug; 66(2):564-574. PMID: 28422306.
      View in: PubMed
    3. Ge J, Roberts JP, Lai J. Race/ethnicity is associated with ABO-nonidentical liver transplantation in the United States. Clin Transplant. 2017 Aug; 31(8). PMID: 28517242.
      View in: PubMed
    4. Wang CW, Lai J. Reporting functional status in UNOS: The weakness of the Karnofsky Performance Status Scale. Clin Transplant. 2017 Jul; 31(7). PMID: 28580753.
      View in: PubMed
    5. Carey EJ, Lai J, Wang CW, Dasarathy S, Lobach I, Montano-Loza AJ, Dunn MA. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017 May; 23(5):625-633. PMID: 28240805.
      View in: PubMed
    6. Salazar J, Saxena V, Kahn JG, Roberts JP, Mehta N, Volk M, Lai J. Cost-Effectiveness of Direct-Acting Antiviral Treatment in Hepatitis C-Infected Liver Transplant Candidates With Compensated Cirrhosis and Hepatocellular Carcinoma. Transplantation. 2017 May; 101(5):1001-1008. PMID: 27926593.
      View in: PubMed
    7. Samoylova ML, Covinsky KE, Haftek M, Kuo S, Roberts JP, Lai J. Disability in patients with end-stage liver disease: Results from the functional assessment in liver transplantation study. Liver Transpl. 2017 Mar; 23(3):292-298. PMID: 27884053.
      View in: PubMed
    8. Sinclair M, Poltavskiy E, Dodge JL, Lai J. Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist. World J Gastroenterol. 2017 Feb 07; 23(5):899-905. PMID: 28223735.
      View in: PubMed
    9. Clinical Liver Disease. A framework to determine when liver transplantation is futile. 2016; 8:137-9.
    10. Pavasini R, Guralnik J, Brown JC, di Bari M, Cesari M, Landi F, Vaes B, Legrand D, Verghese J, Wang C, Stenholm S, Ferrucci L, Lai J, Bartes AA, Espaulella J, Ferrer M, Lim JY, Ensrud KE, Cawthon P, Turusheva A, Frolova E, Rolland Y, Lauwers V, Corsonello A, Kirk GD, Ferrari R, Volpato S, Campo G. Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis. BMC Med. 2016 Dec 22; 14(1):215. PMID: 28003033.
      View in: PubMed
    11. Kuo SZ, Haftek M, Lai J. Factors Associated with Medication Non-adherence in Patients with End-Stage Liver Disease. Dig Dis Sci. 2017 Feb; 62(2):543-549. PMID: 27933471.
      View in: PubMed
    12. Lai J. Editorial: Advancing Adoption of Frailty to Improve the Care of Patients with Cirrhosis: Time for a Consensus on a Frailty Index. Am J Gastroenterol. 2016 Dec; 111(12):1776-1777. PMID: 27924103.
      View in: PubMed
    13. Lai J, Volk ML, Strasburg D, Alexander N, et al. Performance-Based Measures Associate With Frailty in Patients With End-Stage Liver Disease. Transplantation. 2016 Dec; 100(12):2656-2660. PMID: 27495749.
      View in: PubMed
    14. Giard JM, Decker KA, Lai J, Gill RM, Logan AC, Fix OK. Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy. ACG Case Rep J. 2016 Aug; 3(4):e162. PMID: 27921061.
      View in: PubMed
    15. Bajaj JS, O'Leary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Maliakkal B, Biggins SW, Thuluvath P, Fallon MB, Subramanian RM, Vargas HE, Lai J, Thacker LR, Reddy KR. Hepatic Encephalopathy Is Associated With Mortality in Patients With Cirrhosis Independent of Other Extrahepatic Organ Failures. Clin Gastroenterol Hepatol. 2017 Apr; 15(4):565-574.e4. PMID: 27720916.
      View in: PubMed
    16. Kathpalia P, Smith A, Lai J. Underutilization of palliative care services in the liver transplant population. World J Transplant. 2016 Sep 24; 6(3):594-8. PMID: 27683638.
      View in: PubMed
    17. Wang CW, Feng S, Covinsky KE, Hayssen H, Zhou LQ, Yeh BM, Lai J, et al. A Comparison of Muscle Function, Mass, and Quality in Liver Transplant Candidates: Results From the Functional Assessment in Liver Transplantation Study. Transplantation. 2016 Aug; 100(8):1692-8. PMID: 27314169; PMCID: PMC4962324 [Available on 08/01/17].
    18. Lai J, Covinsky KE, Hayssen H, Lizaola B, Dodge J, Roberts JP, Terrault NA, Feng S. Response to clinical assessments of health status as a potential marker to identify patients who are too sick to undergo transplantation. Liver Int. 2016 Apr; 36(4):611. PMID: 26584013.
      View in: PubMed
    19. Lai J, Roberts JP. ABO-Nonidentical Liver Transplantation in the United States. Am J Transplant. 2016 Aug; 16(8):2430-6. PMID: 26932134.
      View in: PubMed
    20. Lai J. Defining the threshold for too sick for transplant. Curr Opin Organ Transplant. 2016 Apr; 21(2):127-32. PMID: 26825359; PMCID: PMC4786446 [Available on 04/01/17].
    21. Lai J, Dodge JL, Sen S, Covinsky K, Feng S. Functional decline in patients with cirrhosis awaiting liver transplantation: Results from the functional assessment in liver transplantation (FrAILT) study. Hepatology. 2016 Feb; 63(2):574-80. PMID: 26517301; PMCID: PMC4718851 [Available on 02/01/17].
    22. Wang CW, Covinsky KE, Feng S, Hayssen H, Segev DL, Lai J. Functional impairment in older liver transplantation candidates: From the functional assessment in liver transplantation study. Liver Transpl. 2015 Dec; 21(12):1465-70. PMID: 26359787; PMCID: PMC4715618 [Available on 12/01/16].
    23. Kwong AJ, Lai J, Dodge JL, Roberts JP. Outcomes for liver transplant candidates listed with low model for end-stage liver disease score. Liver Transpl. 2015 Nov; 21(11):1403-9. PMID: 26289624; PMCID: PMC4838198 [Available on 11/01/16].
    24. Saxena V, Lai J. Kidney Failure and Liver Allocation: Current Practices and Potential Improvements. Adv Chronic Kidney Dis. 2015 Sep; 22(5):391-8. PMID: 26311601; PMCID: PMC4556134.
    25. Volk ML, Goodrich N, Lai J, Sonnenday C, Shedden K. Decision support for organ offers in liver transplantation. Liver Transpl. 2015 Jun; 21(6):784-91. PMID: 25779757; PMCID: PMC4744650.
    26. Campos-Varela I, Lai J, Verna EC, O'Leary JG, Todd Stravitz R, Forman LM, Trotter JF, Brown RS, Terrault NA. Hepatitis C genotype influences post-liver transplant outcomes. Transplantation. 2015 Apr; 99(4):835-40. PMID: 25211520; PMCID: PMC4672637.
    27. Lai J, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300. PMID: 25757956; PMCID: PMC4567539 [Available on 10/01/16].
    28. Lai J, Covinsky KE, Hayssen H, Lizaola B, Dodge JL, Roberts JP, Terrault NA, Feng S. Clinician assessments of health status predict mortality in patients with end-stage liver disease awaiting liver transplantation. Liver Int. 2015 Sep; 35(9):2167-73. PMID: 25644788; PMCID: PMC4517979.
    29. Lai J, Shoback DM, Zipperstein J, Lizaola B, Tseng S, Terrault NA. Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C. Dig Dis Sci. 2015 Jun; 60(6):1813-9. PMID: 25563723; PMCID: PMC4797945.
    30. Bissell DM, Lai J, Meister RK, Blanc PD. Role of delta-aminolevulinic acid in the symptoms of acute porphyria. Am J Med. 2015 Mar; 128(3):313-7. PMID: 25446301; PMCID: PMC4339446.
    31. Sharpton SR, Feng S, Hameed B, Yao F, Lai J. Combined effects of recipient age and model for end-stage liver disease score on liver transplantation outcomes. Transplantation. 2014 Sep 15; 98(5):557-62. PMID: 24717221; PMCID: PMC4461209.
    32. Lai J, Covinsky K, Feng S. The octogenarian donor: can the liver be "younger than stated age"? Am J Transplant. 2014 Sep; 14(9):1962-3. PMID: 25307032; PMCID: PMC4383764.
    33. Feng S, Lai J. Expanded criteria donors. Clin Liver Dis. 2014 Aug; 18(3):633-49. PMID: 25017080; PMCID: PMC4809362.
    34. Lai J, Feng S, Terrault NA, Lizaola B, Hayssen H, Covinsky K. Frailty predicts waitlist mortality in liver transplant candidates. Am J Transplant. 2014 Aug; 14(8):1870-9. PMID: 24935609; PMCID: PMC4107151.
    35. Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab. 2014 May; 99(5):1631-7. PMID: 24483159; PMCID: PMC4010704.
    36. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:156-8. PMID: 24240067; PMCID: PMC4022715.
    37. Lai J, Kahn JG, Tavakol M, Peters MG, Roberts JP. Reducing infection transmission in solid organ transplantation through donor nucleic acid testing: a cost-effectiveness analysis. Am J Transplant. 2013 Oct; 13(10):2611-8. PMID: 24034208; PMCID: PMC4091990.
    38. Lai J, Feng S, Vittinghoff E, Roberts JP. Offer patterns of nationally placed livers by donation service area. Liver Transpl. 2013 Apr; 19(4):404-10. PMID: 23447450; PMCID: PMC3689315.
    39. Halldorson JB, Paarsch HJ, Dodge JL, Segre AM, Lai J, Roberts JP. Center competition and outcomes following liver transplantation. Liver Transpl. 2013 Jan; 19(1):96-104. PMID: 23086897; PMCID: PMC4141491.
    40. Lai J, Feng S, Roberts JP. An examination of liver offers to candidates on the liver transplant wait-list. Gastroenterology. 2012 Nov; 143(5):1261-5. PMID: 22841780; PMCID: PMC3480537.
    41. Lai J, O'Leary JG, Trotter JF, Verna EC, Brown RS, Stravitz RT, Duman JD, Forman LM, Terrault NA. Risk of advanced fibrosis with grafts from hepatitis C antibody-positive donors: a multicenter cohort study. Liver Transpl. 2012 May; 18(5):532-8. PMID: 22271671; PMCID: PMC3334393.
    42. Saxena V, Lai J, O'Leary JG, Verna EC, Brown RS, Stravitz RT, Trotter JF, Krishnan K, Terrault NA. Recipient-donor race mismatch for African American liver transplant patients with chronic hepatitis C. Liver Transpl. 2012 May; 18(5):524-31. PMID: 22140019; PMCID: PMC3314141.
    43. Verna EC, Valadao R, Farrand E, Pichardo EM, Lai J, Terrault NA, Brown RS. Effects of ethnicity and socioeconomic status on survival and severity of fibrosis in liver transplant recipients with hepatitis C virus. Liver Transpl. 2012 Apr; 18(4):461-7. PMID: 22467547; PMCID: PMC3674870.
    44. Lai J, Roberts JP, Vittinghoff E, Terrault NA, Feng S. Patient, center and geographic characteristics of nationally placed livers. Am J Transplant. 2012 Apr; 12(4):947-53. PMID: 22300591; PMCID: PMC3689311.
    45. Brandman D, Pingitore A, Lai J, Roberts JP, Ferrell L, Bass NM, Terrault NA. Hepatic steatosis at 1 year is an additional predictor of subsequent fibrosis severity in liver transplant recipients with recurrent hepatitis C virus. Liver Transpl. 2011 Dec; 17(12):1380-6. PMID: 21770018; PMCID: PMC3712627.
    46. Lai J, Verna EC, Brown RS, O'Leary JG, Trotter JF, Forman LM, Duman JD, Foster RG, Stravitz RT, Terrault NA. Hepatitis C virus-infected women have a higher risk of advanced fibrosis and graft loss after liver transplantation than men. Hepatology. 2011 Aug; 54(2):418-24. PMID: 21538434; PMCID: PMC3144983.
    47. Lai J, Feng S, Roberts JP, Terrault NA. Gender differences in liver donor quality are predictive of graft loss. Am J Transplant. 2011 Feb; 11(2):296-302. PMID: 21219572; PMCID: PMC3076602.
    48. Lai J, Terrault NA, Vittinghoff E, Biggins SW. Height contributes to the gender difference in wait-list mortality under the MELD-based liver allocation system. Am J Transplant. 2010 Dec; 10(12):2658-64. PMID: 21087414; PMCID: PMC3059496.
    49. Monto A, Schooley RT, Lai J, Sulkowski MS, Chung RT, Pawlotsky JM, McHutchison JG, Jacobson IM. Lessons from HIV therapy applied to viral hepatitis therapy: summary of a workshop. Am J Gastroenterol. 2010 May; 105(5):989-1004; quiz 988, 1005. PMID: 20087331.
      View in: PubMed
    50. Lai J, Montero A, Lebwohl B, Brown RS. A novel housestaff educational model for quaternary-care patients at an academic health center. Acad Med. 2009 Feb; 84(2):206-11. PMID: 19174667.
      View in: PubMed
    51. Lai J, Pichardo EM, Emond JC, Brown RS. Resource utilization of living donor versus deceased donor liver transplantation is similar at an experienced transplant center. Am J Transplant. 2009 Mar; 9(3):586-91. PMID: 19191773.
      View in: PubMed
    52. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. PMID: 10.
      View in: PubMed
    53. Holder AA, Wootton JC, Baron AJ, Chambers GK, Fincham JR. The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence. Biochem J. 1975 Sep; 149(3):757-73. PMID: 1002; PMCID: PMC1165685.
    54. Pringle JR. Methods for avoiding proteolytic artefacts in studies of enzymes and other proteins from yeasts. Methods Cell Biol. 1975; 12:149-84. PMID: 589.
      View in: PubMed
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