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Barbara Bensing, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bensing BA, Li L, Yakovenko O, Wong M, Barnard KN, Iverson TM, Lebrilla CB, Parrish CR, Thomas WE, Xiong Y, Sullam PM. Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection. PLoS Pathog. 2019 Jun 24; 15(6):e1007896. PMID: 31233555.
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    2. Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H. An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells. Mol Cell. 2019 Jun 10. PMID: 31227230.
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    3. Braunstein M, Bensing BA, Sullam PM. The Two Distinct Types of SecA2-Dependent Export Systems. Microbiol Spectr. 2019 May; 7(3). PMID: 31215505.
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    4. Malaker SA, Pedram K, Ferracane MJ, Bensing BA, Krishnan V, Pett C, Yu J, Woods EC, Kramer JR, Westerlind U, Dorigo O, Bertozzi CR. The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7278-7287. PMID: 30910957.
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    5. Spencer C, Bensing BA, Mishra NN, Sullam PM. Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery. J Biol Chem. 2019 02 01; 294(5):1502-1515. PMID: 30514759.
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    6. Bensing BA, Li Q, Park D, Lebrilla CB, Sullam PM. Streptococcal Siglec-like adhesins recognize different subsets of human plasma glycoproteins: implications for infective endocarditis. Glycobiology. 2018 08 01; 28(8):601-611. PMID: 29796594.
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    7. Yakovenko O, Nunez J, Bensing B, Yu H, Mount J, Zeng J, Hawkins J, Chen X, Sullam PM, Thomas W. Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets. Infect Immun. 2018 06; 86(6). PMID: 29581195.
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    8. Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA. Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. J Biol Chem. 2018 04 06; 293(14):5360-5373. PMID: 29462788.
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    9. Seepersaud R, Sychantha D, Bensing BA, Clarke AJ, Sullam PM. O-acetylation of the serine-rich repeat glycoprotein GspB is coordinated with accessory Sec transport. PLoS Pathog. 2017 Aug; 13(8):e1006558. PMID: 28827841.
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    10. Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam PM, Iverson TM. Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. Biochemistry. 2016 Oct 25; 55(42):5927-5937. PMID: 27685666.
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    11. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. 2016 11; 26(11):1222-1234. PMID: 27037304.
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    12. Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA. Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1190-9. PMID: 26884191.
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    13. Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM. Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J Biol Chem. 2016 Apr 01; 291(14):7230-40. PMID: 26833566.
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    14. Deng L, Bensing BA, Thamadilok S, Yu H, Lau K, Chen X, Ruhl S, Sullam PM, Varki A. Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood. PLoS Pathog. 2014 Dec; 10(12):e1004540. PMID: 25474103; PMCID: PMC4256463.
    15. Bensing BA, Seepersaud R, Yen YT, Sullam PM. Selective transport by SecA2: an expanding family of customized motor proteins. Biochim Biophys Acta. 2014 Aug; 1843(8):1674-86. PMID: 24184206.
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    16. Yen YT, Cameron TA, Bensing BA, Seepersaud R, Zambryski PC, Sullam PM. Differential localization of the streptococcal accessory sec components and implications for substrate export. J Bacteriol. 2013 Feb; 195(4):682-95. PMID: 23204472.
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    17. Seepersaud R, Bensing BA, Yen YT, Sullam PM. The accessory Sec protein Asp2 modulates GlcNAc deposition onto the serine-rich repeat glycoprotein GspB. J Bacteriol. 2012 Oct; 194(20):5564-75. PMID: 22885294.
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    18. Bensing BA, Yen YT, Seepersaud R, Sullam PM. A Specific interaction between SecA2 and a region of the preprotein adjacent to the signal peptide occurs during transport via the accessory Sec system. J Biol Chem. 2012 Jul 13; 287(29):24438-47. PMID: 22654116.
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    19. Pyburn TM, Bensing BA, Xiong YQ, Melancon BJ, Tomasiak TM, Ward NJ, Yankovskaya V, Oliver KM, Cecchini G, Sulikowski GA, Tyska MJ, Sullam PM, Iverson TM. A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. PLoS Pathog. 2011 Jul; 7(7):e1002112. PMID: 21765814; PMCID: PMC3131266.
    20. Yen YT, Seepersaud R, Bensing BA, Sullam PM. Asp2 and Asp3 interact directly with GspB, the export substrate of the Streptococcus gordonii accessory Sec System. J Bacteriol. 2011 Jul; 193(13):3165-74. PMID: 21531800; PMCID: PMC3133275.
    21. Pyburn TM, Yankovskaya V, Bensing BA, Cecchini G, Sullam PM, Iverson TM. Purification, crystallization and preliminary X-ray diffraction analysis of the carbohydrate-binding region of the Streptococcus gordonii adhesin GspB. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 01; 66(Pt 11):1503-7. PMID: 21045307.
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    22. Seepersaud R, Bensing BA, Yen YT, Sullam PM. Asp3 mediates multiple protein-protein interactions within the accessory Sec system of Streptococcus gordonii. Mol Microbiol. 2010 Oct; 78(2):490-505. PMID: 20807195.
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    23. Bensing BA, Sullam PM. Transport of preproteins by the accessory Sec system requires a specific domain adjacent to the signal peptide. J Bacteriol. 2010 Aug; 192(16):4223-32. PMID: 20562303; PMCID: PMC2916413.
    24. Bensing BA, Sullam PM. Characterization of Streptococcus gordonii SecA2 as a paralogue of SecA. J Bacteriol. 2009 Jun; 191(11):3482-91. PMID: 19363114.
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    25. Xiong YQ, Bensing BA, Bayer AS, Chambers HF, Sullam PM. Role of the serine-rich surface glycoprotein GspB of Streptococcus gordonii in the pathogenesis of infective endocarditis. Microb Pathog. 2008 Oct; 45(4):297-301. PMID: 18656529; PMCID: PMC2574613.
    26. Bensing BA, Siboo IR, Sullam PM. Glycine residues in the hydrophobic core of the GspB signal sequence route export toward the accessory Sec pathway. J Bacteriol. 2007 May; 189(10):3846-54. PMID: 17369296; PMCID: PMC1913339.
    27. Takamatsu D, Bensing BA, Prakobphol A, Fisher SJ, Sullam PM. Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins. Infect Immun. 2006 Mar; 74(3):1933-40. PMID: 16495569; PMCID: PMC1418684.
    28. Bensing BA, Takamatsu D, Sullam PM. Determinants of the streptococcal surface glycoprotein GspB that facilitate export by the accessory Sec system. Mol Microbiol. 2005 Dec; 58(5):1468-81. PMID: 16313630.
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    29. Takamatsu D, Bensing BA, Cheng H, Jarvis GA, Siboo IR, López JA, Griffiss JM, Sullam PM. Binding of the Streptococcus gordonii surface glycoproteins GspB and Hsa to specific carbohydrate structures on platelet membrane glycoprotein Ibalpha. Mol Microbiol. 2005 Oct; 58(2):380-92. PMID: 16194227.
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    30. Takamatsu D, Bensing BA, Sullam PM. Two additional components of the accessory sec system mediating export of the Streptococcus gordonii platelet-binding protein GspB. J Bacteriol. 2005 Jun; 187(11):3878-83. PMID: 15901716; PMCID: PMC1112061.
    31. Bensing BA, López JA, Sullam PM. The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibalpha. Infect Immun. 2004 Nov; 72(11):6528-37. PMID: 15501784; PMCID: PMC523053.
    32. Takamatsu D, Bensing BA, Sullam PM. Four proteins encoded in the gspB-secY2A2 operon of Streptococcus gordonii mediate the intracellular glycosylation of the platelet-binding protein GspB. J Bacteriol. 2004 Nov; 186(21):7100-11. PMID: 15489421; PMCID: PMC523221.
    33. Takamatsu D, Bensing BA, Sullam PM. Genes in the accessory sec locus of Streptococcus gordonii have three functionally distinct effects on the expression of the platelet-binding protein GspB. Mol Microbiol. 2004 Apr; 52(1):189-203. PMID: 15049820.
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    34. Bensing BA, Gibson BW, Sullam PM. The Streptococcus gordonii platelet binding protein GspB undergoes glycosylation independently of export. J Bacteriol. 2004 Feb; 186(3):638-45. PMID: 14729688; PMCID: PMC321503.
    35. Siboo IR, Bensing BA, Sullam PM. Genomic organization and molecular characterization of SM1, a temperate bacteriophage of Streptococcus mitis. J Bacteriol. 2003 Dec; 185(23):6968-75. PMID: 14617660; PMCID: PMC262713.
    36. Bensing BA, Sullam PM. An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets. Mol Microbiol. 2002 May; 44(4):1081-94. PMID: 12010500.
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    37. Bensing BA, Siboo IR, Sullam PM. Proteins PblA and PblB of Streptococcus mitis, which promote binding to human platelets, are encoded within a lysogenic bacteriophage. Infect Immun. 2001 Oct; 69(10):6186-92. PMID: 11553559; PMCID: PMC98750.
    38. Bensing BA, Rubens CE, Sullam PM. Genetic loci of Streptococcus mitis that mediate binding to human platelets. Infect Immun. 2001 Mar; 69(3):1373-80. PMID: 11179301.
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    39. Bensing BA, Manias DA, Dunny GM. Pheromone cCF10 and plasmid pCF10-encoded regulatory molecules act post-transcriptionally to activate expression of downstream conjugation functions. Mol Microbiol. 1997 Apr; 24(2):285-94. PMID: 9159516.
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    40. Bensing BA, Dunny GM. Pheromone-inducible expression of an aggregation protein in Enterococcus faecalis requires interaction of a plasmid-encoded RNA with components of the ribosome. Mol Microbiol. 1997 Apr; 24(2):295-308. PMID: 9159517.
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    41. Bensing BA, Meyer BJ, Dunny GM. Sensitive detection of bacterial transcription initiation sites and differentiation from RNA processing sites in the pheromone-induced plasmid transfer system of Enterococcus faecalis. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):7794-9. PMID: 8755555.
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    42. Chung JW, Bensing BA, Dunny GM. Genetic analysis of a region of the Enterococcus faecalis plasmid pCF10 involved in positive regulation of conjugative transfer functions. J Bacteriol. 1995 Apr; 177(8):2107-17. PMID: 7721703.
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    43. Leonard BA, Bensing BA, Hedberg PJ, Ruhfel RE, Chung JW, Dunny GM. Pheromone-inducible gene regulation and signalling for the control of aggregation substance expression in the conjugative plasmid pCF10. Dev Biol Stand. 1995; 85:27-34. PMID: 8586188.
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    44. Bensing BA, Dunny GM. Cloning and molecular analysis of genes affecting expression of binding substance, the recipient-encoded receptor(s) mediating mating aggregate formation in Enterococcus faecalis. J Bacteriol. 1993 Nov; 175(22):7421-9. PMID: 8226689.
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