Susan Fisher, PhD

Title(s)Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Address35 Medical Center Way
San Francisco CA 94143
Phone415-476-1092
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    Our group works in three areas. In the first, we are studying the mechanisms used by the trophoblast cells of the human placenta to invade the uterus during normal pregnancy. Human fetal development depends on the embryo's ability to rapidly gain access to the maternal circulation. The cytotrophoblasts that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain invasive, tumor-like properties. Our studies show that, in normal pregnancy, cytotrophoblast invasion, both in vivo and in vitro, is accompanied by a dramatic switch in the cells' expression of matrix-degrading metalloproteinases and adhesion molecules. Function-perturbation experiments suggest that cytotrophoblasts carefully regulate their invasive potential by simultaneously expressing a number of molecules that either promote or inhibit invasion. Additionally, we found that cytotrophoblasts that replace the endothelial lining of uterine blood vessels also have the amazing ability to mimic the adhesion phenotype of vascular cells. This phenomenon is likely to be a critical component of normal placentation. What controls this highly unusual differentiation process? Since cytotrophoblasts target large-bore arterioles for invasion, we reasoned that oxygen tension could play a role. Recently, we showed that oxygen controls whether cells proliferate or exit the cell cycle and differentiate; Eph/ephrin family members, transmembrane ligands and receptors, pattern invasion in terms of arterial bias. Finally, we use information about molecular aspects of cytotrophoblast function in normal pregnancy to search for defects that are associated with pregnancy complications such as preeclampsia (e.g., dangerously high blood pressure). For example, our work shows that this pregnancy complication is characterized by specific aberrations in trophoblast secretion of vasculogenic/angiogenic substances.

    In parallel, our lab has begun studying the earliest stages of human development using human embryonic stem cells as a model system. Our work to date has focused on deriving additional lines using feeders formed from human placental cells. We recently made the surprising discovery that the cells exhibit apical-basal type polarization. Currently we are investigating how this highly specialized phenomenon is related to pluripotency. Our recently funded CIRM comprehensive grant is focused on constructing a fate map of the human embryo.

    Finally, we are using mass spectrometry-based approaches for proteome analyses. Three projects are under way. The first is compilation of an initial draft of the salivary proteome of healthy individuals as a first step in using this body fluid for diagnosis of common diseases. The second is an analysis of the primary proteome and protein complexes of the soil organism Desulfovibrio vulgaris. The goal of the third and newest project is to formulate novel methods that enable robust mass spectrometry-based platforms for the discovery of biomarkers in body fluid for the early detection of tumors.

    Collapse Research 
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    THC effects on human implantation: role of trophoblast CB1
    NIH R21DA042951Feb 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Dissecting gene dysregulation at the maternal-fetal interface in preeclampsia
    NIH R37HD076253Sep 25, 2013 - Jun 30, 2023
    Role: Principal Investigator
    Dissecting gene dysregulation at the maternal-fetal interface in preeclampsia
    NIH/NICHD R01HD076253Sep 25, 2013 - Jun 30, 2018
    Role: Principal Investigator
    The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center
    NIH P01ES022841Jun 15, 2013 - May 31, 2019
    Role: Co-Investigator
    A Novel Model for Assessing the Effects of BPA Exposures on Human Placentation
    NIH R21ES019944Sep 20, 2012 - Aug 31, 2015
    Role: Principal Investigator
    Fetal Programming and Environmental Exposures: Implications for Prenatal Care and
    NIH R13ES021699Aug 7, 2012 - Jun 30, 2013
    Role: Co-Principal Investigator
    Mass Spectrometry Tools in Pursuit of Salivary Biomarkers of Sjogren's Syndrome
    NIH R01DE022031May 1, 2012 - Apr 30, 2018
    Role: Principal Investigator
    Functional Glycomics of Human Saliva
    NIH R01DE021041Apr 1, 2011 - Mar 31, 2017
    Role: Principal Investigator
    Molecular Mechanisms of Plasmodium Falciparum Adherence to the Human Placenta
    NIH R21AI079329May 7, 2009 - Apr 30, 2012
    Role: Principal Investigator
    The Immune Paradox of Human Pregnancy: Fetal Trophoblasts and Maternal Leukocytes
    NIH R21HD055638Aug 1, 2008 - Jul 31, 2011
    Role: Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Co-Investigator
    Center for Research, Innovation and Training in Reproduction and Infertility
    NIH P50HD055764Apr 1, 2007 - Mar 31, 2023
    Role: Co-Investigator
    Targeted and global proteomic strategies for early breast cancer detection
    NIH U24CA126477Sep 28, 2006 - Aug 31, 2013
    Role: Principal Investigator
    Neuronal Guidance Mechanisms in Placental Development
    NIH R01HD046744Dec 15, 2004 - Nov 30, 2010
    Role: Principal Investigator
    Cataloguing the Human Salivary Proteome
    NIH U01DE016274Sep 24, 2004 - May 31, 2010
    Role: Principal Investigator
    Trophoblast Selectins and Their Uterine Mucin Ligands
    NIH U01HD042283Apr 1, 2002 - Mar 31, 2008
    Role: Principal Investigator
    GORDON RESEARCH CONFERENCE ON REPRODUCTIVE TRACT BIOLOGY
    NIH R13HD039168May 1, 2000 - Apr 30, 2001
    Role: Principal Investigator
    A NOVEL VASCULOGENESIS PROGRAM IN CYTOTROPHOBLASTS
    NIH R01HL064597Mar 7, 2000 - Feb 28, 2005
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA082103Aug 5, 1999 - May 31, 2023
    Role: Co-Investigator
    NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    NIH P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    CANDIDA ADHERENCE
    NIH R01DE011350Sep 30, 1994 - Sep 29, 1997
    Role: Principal Investigator
    Mechanisms of Preeclampsia: Impact of Obesity
    NIH P01HD030367Apr 1, 1993 - Mar 31, 2014
    Role: Co-Investigator
    DEVELOPMENTAL BIOLOGY OF THE IMPLANTING MAMMALIAN EMBRYO
    NIH P01HD026732Feb 1, 1991 - Jan 31, 2002
    Role: Co-Investigator
    MECHANISMS OF TROPHOBLAST INVASION DURING PLACENTATION
    NIH R01HD022518Feb 1, 1988 - Jan 31, 1991
    Role: Principal Investigator
    PRENATAL DIAGNOSIS USING FETAL CELLS FROM MATERNAL BLOOD
    NIH/NICHD N01HD082903Dec 31, 1987 - Mar 31, 1992
    Role: Principal Investigator
    MOLECULAR MECHANISMS--BACTERIAL ADHERENCE TO CEMENTUM
    NIH R37DE007244Apr 1, 1985 - Feb 28, 2009
    Role: Principal Investigator
    MOLECULAR MECHANISMS--BACTERIAL ADHERENCE TO CEMENTUM
    NIH R01DE007244Apr 1, 1985 - Mar 31, 2004
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Global proteomic analyses of human cytotrophoblast differentiation/invasion. Development. 2021 Jul 01; 148(13). Chen H, Williams KE, Kwan EY, Kapidzic M, Puckett KA, Aburajab RK, Robinson JF, Fisher SJ. PMID: 34121116.
      View in: PubMed   Mentions:    Fields:    
    2. The Placenta - Fast, Loose, and in Control. N Engl J Med. 2021 Jul 01; 385(1):87-89. Costello JF, Fisher SJ. PMID: 34192437.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Organophosphate Flame Retardants, Highly Fluorinated Chemicals, and Biomarkers of Placental Development and Disease During Mid-Gestation. Toxicol Sci. 2021 05 27; 181(2):215-228. Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Gao S, Smith SC, Park JS, Zakharevich I, Gerona RR, Fisher SJ, Woodruff TJ. PMID: 33677611.
      View in: PubMed   Mentions:    Fields:    
    4. Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease. Dev Cell. 2021 May 03; 56(9):1238-1252.e5. Zhang B, Kim MY, Elliot G, Zhou Y, Zhao G, Li D, Lowdon RF, Gormley M, Kapidzic M, Robinson JF, McMaster MT, Hong C, Mazor T, Hamilton E, Sears RL, Pehrsson EC, Marra MA, Jones SJM, Bilenky M, Hirst M, Wang T, Costello JF, Fisher SJ. PMID: 33891899.
      View in: PubMed   Mentions:    Fields:    
    5. Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNFa. Development. 2020 09 08; 147(17). Taylor SK, Houshdaran S, Robinson JF, Gormley MJ, Kwan EY, Kapidzic M, Schilling B, Giudice LC, Fisher SJ. PMID: 32747437.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Gravidity-dependent associations between interferon response and birth weight in placental malaria. Malar J. 2020 Aug 05; 19(1):280. Quanquin NM, Barres LG, Aliyari SR, Day NT, Gerami H, Fisher SJ, Kakuru A, Kamya MR, Havlir DV, Feeney M, Dorsey G, Cheng G, Gaw SL. PMID: 32758231.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation. Sci Rep. 2020 07 22; 10(1):12247. Varshavsky JR, Sen S, Robinson JF, Smith SC, Frankenfield J, Wang Y, Yeh G, Park JS, Fisher SJ, Woodruff TJ. PMID: 32699379.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    8. Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15852-15861. McNally L, Zhou Y, Robinson JF, Zhao G, Chen LM, Chen H, Kim MY, Kapidzic M, Gormley M, Hannibal R, Fisher SJ. PMID: 32576693.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation. Environ Health. 2020 06 03; 19(1):61. Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Smith SC, Frankenfield J, Park JS, Fisher SJ, Woodruff TJ. PMID: 32493340.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    10. Discordant Zika Virus Findings in Twin Pregnancies Complicated by Antenatal Zika Virus Exposure: A Prospective Cohort. J Infect Dis. 2020 05 11; 221(11):1838-1845. Sobhani NC, Avvad-Portari E, Nascimento ACM, Machado HN, Lobato DSS, Pereira JP, Esquivel MS, Vasconcelos ZC, Zin AA, Tsui I, Adachi K, Brickley EB, Fisher SJ, Nielsen-Saines K, Brasil P, Moreira ME, Gaw SL. PMID: 31773163.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface. Reprod Sci. 2020 01; 27(1):100-109. Leon-Martinez D, Robinson JF, Zdravkovic T, Genbacev O, Gormley M, Mcmaster M, Fisher SJ, Bianco K. PMID: 32046398.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Differential Activation of Fetal Hofbauer Cells in Primigravidas Is Associated with Decreased Birth Weight in Symptomatic Placental Malaria. Malar Res Treat. 2019; 2019:1378174. Gaw SL, Hromatka BS, Ngeleza S, Buarpung S, Ozarslan N, Tshefu A, Fisher SJ. PMID: 31186834.
      View in: PubMed   Mentions:
    13. Placental Structure in Preterm Birth Among HIV-Positive Versus HIV-Negative Women in Kenya. . 2019 01 01; 80(1):94-102. Obimbo MM, Zhou Y, McMaster MT, Cohen CR, Qureshi Z, Ong'ech J, Ogeng'o JA, Fisher SJ. PMID: 30272633.
      View in: PubMed   Mentions:
    14. Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts. Toxicol Sci. 2019 01 01; 167(1):211-226. Robinson JF, Kapidzic M, Hamilton EG, Chen H, Puckett KW, Zhou Y, Ona K, Parry E, Wang Y, Park JS, Costello JF, Fisher SJ. PMID: 30202865.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Reply to Liu et al.: Decidualization defect in severe preeclampsia. Proc Natl Acad Sci U S A. 2018 08 14; 115(33):E7656-E7657. Garrido-Gomez T, Fisher SJ, Simón C. PMID: 30068606.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Altered downstream target gene expression of the placental Vitamin D receptor in human idiopathic fetal growth restriction. . 2018; 17(2):182-190. Nguyen TPH, Yong HEJ, Chollangi T, Brennecke SP, Fisher SJ, Wallace EM, Ebeling PR, Murthi P. PMID: 29161966.
      View in: PubMed   Mentions:
    17. Baby's First Organ. Sci Am. 2017 Sep 19; 317(4):46-53. Erlebacher A, Fisher SJ. PMID: 29565852.
      View in: PubMed   Mentions: 1     Fields:    
    18. Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):E8468-E8477. Garrido-Gomez T, Dominguez F, Quiñonero A, Diaz-Gimeno P, Kapidzic M, Gormley M, Ona K, Padilla-Iserte P, McMaster M, Genbacev O, Perales A, Fisher SJ, Simón C. PMID: 28923940.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    19. Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology. 2017 06 01; 158(6):1581-1594. Robinson JF, Kapidzic M, Gormley M, Ona K, Dent T, Seifikar H, Hamilton EG, Fisher SJ. PMID: 28323933.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Alterations in the Salivary Proteome and N-Glycome of Sjögren's Syndrome Patients. J Proteome Res. 2017 04 07; 16(4):1693-1705. Hall SC, Hassis ME, Williams KE, Albertolle ME, Prakobphol A, Dykstra AB, Laurance M, Ona K, Niles RK, Prasad N, Gormley M, Shiboski C, Criswell LA, Witkowska HE, Fisher SJ. PMID: 28282148.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations. Am J Obstet Gynecol. 2017 08; 217(2):200.e1-200.e17. Gormley M, Ona K, Kapidzic M, Garrido-Gomez T, Zdravkovic T, Fisher SJ. PMID: 28347715.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    22. The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation. Development. 2017 04 15; 144(8):1399-1411. Muench MO, Kapidzic M, Gormley M, Gutierrez AG, Ponder KL, Fomin ME, Beyer AI, Stolp H, Qi Z, Fisher SJ, Bárcena A. PMID: 28255007.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    23. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion. Development. 2017 03 01; 144(5):767-777. Garrido-Gomez T, Ona K, Kapidzic M, Gormley M, Simón C, Genbacev O, Fisher SJ. PMID: 28232601.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    24. Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects. Prenat Diagn. 2016 Sep; 36(9):812-22. Bianco K, Gormley M, Farrell J, Zhou Y, Oliverio O, Tilden H, McMaster M, Fisher SJ. PMID: 27328057.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Stromal Cell-Derived Factor 2: A Novel Protein that Interferes in Endoplasmic Reticulum Stress Pathway in Human Placental Cells. Biol Reprod. 2016 08; 95(2):41. Lorenzon-Ojea AR, Guzzo CR, Kapidzic M, Fisher SJ, Bevilacqua E. PMID: 27335075.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Quantitative Tagless Copurification: A Method to Validate and Identify Protein-Protein Interactions. Mol Cell Proteomics. 2016 06; 15(6):2186-202. Shatsky M, Dong M, Liu H, Yang LL, Choi M, Singer ME, Geller JT, Fisher SJ, Hall SC, Hazen TC, Brenner SE, Butland G, Jin J, Witkowska HE, Chandonia JM, Biggin MD. PMID: 27099342.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    27. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. 2016 11; 26(11):1222-1234. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. PMID: 27037304.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    28. Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche. Reprod Sci. 2016 09; 23(9):1179-92. Ponder KL, Bárcena A, Bos FL, Gormley M, Zhou Y, Ona K, Kapidzic M, Zovein AC, Fisher SJ. PMID: 26944948.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1343-51. Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z. PMID: 26903627.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    30. Bacterial Interactomes: Interacting Protein Partners Share Similar Function and Are Validated in Independent Assays More Frequently Than Previously Reported. Mol Cell Proteomics. 2016 05; 15(5):1539-55. Shatsky M, Allen S, Gold BL, Liu NL, Juba TR, Reveco SA, Elias DA, Prathapam R, He J, Yang W, Szakal ED, Liu H, Singer ME, Geller JT, Lam BR, Saini A, Trotter VV, Hall SC, Fisher SJ, Brenner SE, Chhabra SR, Hazen TC, Wall JD, Witkowska HE, Biggin MD, Chandonia JM, Butland G. PMID: 26873250.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    31. Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation. Clin Proteomics. 2015; 12:29. Albertolle ME, Hassis ME, Ng CJ, Cuison S, Williams K, Prakobphol A, Dykstra AB, Hall SC, Niles RK, Ewa Witkowska H, Fisher SJ. PMID: 26719750.
      View in: PubMed   Mentions:
    32. Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification. Development. 2015 Dec 01; 142(23):4010-25. Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ. PMID: 26483210.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    33. Placenta: the forgotten organ. Annu Rev Cell Dev Biol. 2015; 31:523-52. Maltepe E, Fisher SJ. PMID: 26443191.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    34. Why is placentation abnormal in preeclampsia? Am J Obstet Gynecol. 2015 Oct; 213(4 Suppl):S115-22. Fisher SJ. PMID: 26428489.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    35. Human Stem Cells from Single Blastomeres Reveal Pathways of Embryonic or Trophoblast Fate Specification (in Press). Development. 2015. Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapiller N, Gnanaratnam G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, and Fisher SJ. .
    36. Evaluating the effects of preanalytical variables on the stability of the human plasma proteome. Anal Biochem. 2015 Jun 01; 478:14-22. Hassis ME, Niles RK, Braten MN, Albertolle ME, Ewa Witkowska H, Hubel CA, Fisher SJ, Williams KE. PMID: 25769420.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    37. Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30. Roadmap Epigenomics Consortium , Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. PMID: 25693563.
      View in: PubMed   Mentions: 1975     Fields:    Translation:HumansCells
    38. Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma. Mol Cell Proteomics. 2015 Sep; 14(9):2357-74. Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA. PMID: 25693799.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    39. Roadmay Epigenomics Consortium: Integrative Analysis of 111 Reference Human Epigenomes. Nature. 2015; 518(19):317-330. Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M.
    40. Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals. J Proteomics. 2015 Jan 15; 113:194-205. Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice LC, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ. PMID: 25284053.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    41. Rbpj links uterine transformation and embryo orientation. Cell Res. 2014 Sep; 24(9):1031-2. Robinson JF, Fisher SJ. PMID: 25145360.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    42. Preterm labor: one syndrome, many causes. Science. 2014 Aug 15; 345(6198):760-5. Romero R, Dey SK, Fisher SJ. PMID: 25124429.
      View in: PubMed   Mentions: 436     Fields:    Translation:Humans
    43. Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition. Electrophoresis. 2014 Dec; 35(24):3487-97. Zawadzka AM, Schilling B, Held JM, Sahu AK, Cusack MP, Drake PM, Fisher SJ, Gibson BW. PMID: 24853916.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
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    110. Functional and placental expression analysis of the human NRF3 transcription factor. Mol Endocrinol. 2005 Jan; 19(1):125-37. Chénais B, Derjuga A, Massrieh W, Red-Horse K, Bellingard V, Fisher SJ, Blank V. PMID: 15388789.
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    111. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest. 2004 Sep; 114(6):744-54. Red-Horse K, Zhou Y, Genbacev O, Prakobphol A, Foulk R, McMaster M, Fisher SJ. PMID: 15372095.
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    112. The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol. 2004 Jul 05; 2:53. Fisher SJ. PMID: 15236649.
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    113. Human pregnancy: the role of chemokine networks at the fetal-maternal interface. Expert Rev Mol Med. 2004 May 10; 6(11):1-14. Red-Horse K, Drake PM, Fisher SJ. PMID: 15130179.
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    114. Reciprocal chemokine receptor and ligand expression in the human placenta: implications for cytotrophoblast differentiation. Dev Dyn. 2004 Apr; 229(4):877-85. Drake PM, Red-Horse K, Fisher SJ. PMID: 15042711.
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    115. Listeriosis in the pregnant guinea pig: a model of vertical transmission. Infect Immun. 2004 Jan; 72(1):489-97. Bakardjiev AI, Stacy BA, Fisher SJ, Portnoy DA. PMID: 14688130.
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    116. Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C. Dev Biol. 2003 Nov 01; 263(1):114-25. Zhou Y, Bellingard V, Feng KT, McMaster M, Fisher SJ. PMID: 14568550.
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    117. Disruption of oxygen-regulated responses underlies pathological changes in the placentas of women who smoke or who are passively exposed to smoke during pregnancy. Reprod Toxicol. 2003 Sep-Oct; 17(5):509-18. Genbacev O, McMaster MT, Zdravkovic T, Fisher SJ. PMID: 14555188.
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    118. The human placenta remodels the uterus by using a combination of molecules that govern vasculogenesis or leukocyte extravasation. Ann N Y Acad Sci. 2003 May; 995:73-83. Zhou Y, Genbacev O, Fisher SJ. PMID: 12814940.
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    119. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003 Jan 17; 299(5605):405-8. Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, Yang ZQ, Kiessling LL, Rosen SD, Fisher SJ. PMID: 12532021.
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    120. Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies. Am J Obstet Gynecol. 2003 Jan; 188(1):177-82. Taylor RN, Grimwood J, Taylor RS, McMaster MT, Fisher SJ, North RA. PMID: 12548214.
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    121. Transmission of human cytomegalovirus from infected uterine microvascular endothelial cells to differentiating/invasive placental cytotrophoblasts. Virology. 2002 Dec 05; 304(1):53-69. Maidji E, Percivalle E, Gerna G, Fisher S, Pereira L. PMID: 12490403.
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    122. Chemokine expression and function at the human maternal-fetal interface. Rev Endocr Metab Disord. 2002 May; 3(2):159-65. Drake PM, Red-Horse K, Fisher SJ. PMID: 12007293.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    123. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002 Apr; 160(4):1405-23. Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ. PMID: 11943725.
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    124. The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology. 2002 Jan; 12(1):1-14. Thomsson KA, Prakobphol A, Leffler H, Reddy MS, Levine MJ, Fisher SJ, Hansson GC. PMID: 11825880.
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    125. HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression. Hum Immunol. 2000 Nov; 61(11):1177-95. Paul P, Rouas-Freiss N, Moreau P, Cabestre FA, Menier C, Khalil-Daher I, Pangault C, Onno M, Fauchet R, Martinez-Laso J, Morales P, Villena AA, Giacomini P, Natali PG, Frumento G, Ferrara GB, McMaster M, Fisher S, Schust D, Ferrone S, Dausset J, Geraghty D, Carosella ED. PMID: 11137224.
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    126. Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia. Mol Hum Reprod. 2000 Jan; 6(1):88-95. Goldman-Wohl DS, Ariel I, Greenfield C, Hochner-Celnikier D, Cross J, Fisher S, Yagel S. PMID: 10611266.
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    127. Complementary expression of HIP, a cell-surface heparan sulfate binding protein, and perlecan at the human fetal-maternal interface. Biol Reprod. 1998 Apr; 58(4):1075-83. Rohde LH, Janatpore MJ, McMaster MT, Fisher S, Zhou Y, Lim KH, French M, Hoke D, Julian J, Carson DD. PMID: 9546743.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    128. PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins. Am J Hum Genet. 1996 Jan; 58(1):143-53. Azen EA, Amberger E, Fisher S, Prakobphol A, Niece RL. PMID: 8554050.
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    129. Human cytotrophoblast invasion. Semin Cell Biol. 1993 Jun; 4(3):183-8. Fisher SJ, Damsky CH. PMID: 8347835.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    130. Human placental (fetal) fibronectin: increased glycosylation and higher protease resistance than plasma fibronectin. Presence of polylactosamine glycopeptides and properties of a 44-kilodalton chymotryptic collagen-binding domain: difference from human plasma fibronectin. J Biol Chem. 1984 Mar 25; 259(6):3962-70. Zhu BC, Fisher SF, Pande H, Calaycay J, Shively JE, Laine RA. PMID: 6423638.
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    131. Carbohydrate structure of the major glycopeptide from human cold-insoluble globulin. J Supramol Struct. 1979; 11(3):391-9. Fisher SJ, Laine RA. PMID: 120906.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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