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Susan Fisher, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentOb/Gyn, Reproductive Sciences
Address35 Medical Center Way
San Francisco CA 94143
Phone415-476-5297
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    Our group works in three areas. In the first, we are studying the mechanisms used by the trophoblast cells of the human placenta to invade the uterus during normal pregnancy. Human fetal development depends on the embryo's ability to rapidly gain access to the maternal circulation. The cytotrophoblasts that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain invasive, tumor-like properties. Our studies show that, in normal pregnancy, cytotrophoblast invasion, both in vivo and in vitro, is accompanied by a dramatic switch in the cells' expression of matrix-degrading metalloproteinases and adhesion molecules. Function-perturbation experiments suggest that cytotrophoblasts carefully regulate their invasive potential by simultaneously expressing a number of molecules that either promote or inhibit invasion. Additionally, we found that cytotrophoblasts that replace the endothelial lining of uterine blood vessels also have the amazing ability to mimic the adhesion phenotype of vascular cells. This phenomenon is likely to be a critical component of normal placentation. What controls this highly unusual differentiation process? Since cytotrophoblasts target large-bore arterioles for invasion, we reasoned that oxygen tension could play a role. Recently, we showed that oxygen controls whether cells proliferate or exit the cell cycle and differentiate; Eph/ephrin family members, transmembrane ligands and receptors, pattern invasion in terms of arterial bias. Finally, we use information about molecular aspects of cytotrophoblast function in normal pregnancy to search for defects that are associated with pregnancy complications such as preeclampsia (e.g., dangerously high blood pressure). For example, our work shows that this pregnancy complication is characterized by specific aberrations in trophoblast secretion of vasculogenic/angiogenic substances.

    In parallel, our lab has begun studying the earliest stages of human development using human embryonic stem cells as a model system. Our work to date has focused on deriving additional lines using feeders formed from human placental cells. We recently made the surprising discovery that the cells exhibit apical-basal type polarization. Currently we are investigating how this highly specialized phenomenon is related to pluripotency. Our recently funded CIRM comprehensive grant is focused on constructing a fate map of the human embryo.

    Finally, we are using mass spectrometry-based approaches for proteome analyses. Three projects are under way. The first is compilation of an initial draft of the salivary proteome of healthy individuals as a first step in using this body fluid for diagnosis of common diseases. The second is an analysis of the primary proteome and protein complexes of the soil organism Desulfovibrio vulgaris. The goal of the third and newest project is to formulate novel methods that enable robust mass spectrometry-based platforms for the discovery of biomarkers in body fluid for the early detection of tumors.


    Collapse Research 
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    THC effects on human implantation: role of trophoblast CB1
    NIH/NIDA R21DA042951Feb 1, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Dissecting gene dysregulation at the maternal-fetal interface in preeclampsia
    NIH/NICHD R37HD076253Sep 25, 2013 - Jun 30, 2023
    Role: Principal Investigator
    Dissecting gene dysregulation at the maternal-fetal interface in preeclampsia
    NIH/NICHD R01HD076253Sep 25, 2013 - Jun 30, 2018
    Role: Principal Investigator
    The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center
    NIH/NIEHS P01ES022841Jun 15, 2013 - May 31, 2018
    Role: Co-Investigator
    A Novel Model for Assessing the Effects of BPA Exposures on Human Placentation
    NIH/NIEHS R21ES019944Sep 20, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Fetal Programming and Environmental Exposures: Implications for Prenatal Care and
    NIH/NIEHS R13ES021699Aug 7, 2012 - Jun 30, 2013
    Role: Co-Principal Investigator
    Functional Glycomics of Human Saliva
    NIH/NIDCR R01DE021041Apr 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Molecular Mechanisms of Plasmodium Falciparum Adherence to the Human Placenta
    NIH/NIAID R21AI079329May 7, 2009 - Apr 30, 2012
    Role: Principal Investigator
    The Immune Paradox of Human Pregnancy: Fetal Trophoblasts and Maternal Leukocytes
    NIH/NICHD R21HD055638Aug 1, 2008 - Jul 31, 2011
    Role: Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH/NICHD U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Co-Investigator
    Center for Research, Innovation and Training in Reproduction and Infertility
    NIH/NICHD P50HD055764Apr 1, 2007 - Mar 31, 2023
    Role: Co-Investigator
    Targeted and global proteomic strategies for early breast cancer detection
    NIH/NCI U24CA126477Sep 28, 2006 - Aug 31, 2013
    Role: Principal Investigator
    Neuronal Guidance Mechanisms in Placental Development
    NIH/NICHD R01HD046744Dec 15, 2004 - Nov 30, 2010
    Role: Principal Investigator
    Cataloguing the Human Salivary Proteome
    NIH/NIDCR U01DE016274Sep 24, 2004 - May 31, 2010
    Role: Principal Investigator
    Trophoblast Selectins and Their Uterine Mucin Ligands
    NIH/NICHD U01HD042283Apr 1, 2002 - Mar 31, 2008
    Role: Principal Investigator
    GORDON RESEARCH CONFERENCE ON REPRODUCTIVE TRACT BIOLOGY
    NIH/NICHD R13HD039168May 1, 2000 - Apr 30, 2001
    Role: Principal Investigator
    A NOVEL VASCULOGENESIS PROGRAM IN CYTOTROPHOBLASTS
    NIH/NHLBI R01HL064597Mar 7, 2000 - Feb 28, 2005
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH/NCI P30CA082103Aug 5, 1999 - May 31, 2018
    Role: Co-Investigator
    NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    NIH/NIDCR P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    CANDIDA ADHERENCE
    NIH/NIDCR R01DE011350Sep 30, 1994 - Sep 29, 1997
    Role: Principal Investigator
    Mechanisms of Preeclampsia: Impact of Obesity
    NIH P01HD030367Apr 1, 1993 - Mar 31, 2014
    Role: Co-Investigator
    DEVELOPMENTAL BIOLOGY OF THE IMPLANTING MAMMALIAN EMBRYO
    NIH/NICHD P01HD026732Feb 1, 1991 - Jan 31, 2002
    Role: Co-Investigator
    MECHANISMS OF TROPHOBLAST INVASION DURING PLACENTATION
    NIH/NICHD R01HD022518Feb 1, 1988 - Jan 31, 1991
    Role: Principal Investigator
    PRENATAL DIAGNOSIS USING FETAL CELLS FROM MATERNAL BLOOD
    NIH/NICHD N01HD082903Dec 31, 1987 - Mar 31, 1992
    Role: Principal Investigator
    MOLECULAR MECHANISMS--BACTERIAL ADHERENCE TO CEMENTUM
    NIH/NIDCR R37DE007244Apr 1, 1985 - Feb 28, 2009
    Role: Principal Investigator
    MOLECULAR MECHANISMS--BACTERIAL ADHERENCE TO CEMENTUM
    NIH/NIDCR R01DE007244Apr 1, 1985 - Mar 31, 2004
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Obimbo MM, Zhou Y, Mcmaster MT, Cohen CR, Qureshi Z, Ong'ech J, Ogeng'o JA, Fisher SJ. Placental structure in preterm birth amongst HIV positive versus negative women in Kenya. J Acquir Immune Defic Syndr. 2018 Sep 27. PMID: 30272633.
      View in: PubMed
    2. Garrido-Gomez T, Fisher SJ, Simón C. Reply to Liu et al.: Decidualization defect in severe preeclampsia. Proc Natl Acad Sci U S A. 2018 Aug 01. PMID: 30068606.
      View in: PubMed
    3. Nguyen TPH, Yong HEJ, Chollangi T, Brennecke SP, Fisher SJ, Wallace EM, Ebeling PR, Murthi P. Altered downstream target gene expression of the placental Vitamin D receptor in human idiopathic fetal growth restriction. Cell Cycle. 2018; 17(2):182-190. PMID: 29161966.
      View in: PubMed
    4. Erlebacher A, Fisher SJ. Baby's First Organ. Sci Am. 2017 Sep 19; 317(4):46-53. PMID: 29565852.
      View in: PubMed
    5. Garrido-Gomez T, Dominguez F, Quiñonero A, Diaz-Gimeno P, Kapidzic M, Gormley M, Ona K, Padilla-Iserte P, McMaster M, Genbacev O, Perales A, Fisher SJ, Simón C. Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):E8468-E8477. PMID: 28923940.
      View in: PubMed
    6. Robinson JF, Kapidzic M, Gormley M, Ona K, Dent T, Seifikar H, Hamilton EG, Fisher SJ. Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology. 2017 06 01; 158(6):1581-1594. PMID: 28323933.
      View in: PubMed
    7. Hall SC, Hassis ME, Williams KE, Albertolle ME, Prakobphol A, Dykstra AB, Laurance M, Ona K, Niles RK, Prasad N, Gormley M, Shiboski C, Criswell LA, Witkowska HE, Fisher SJ. Alterations in the Salivary Proteome and N-Glycome of Sjögren's Syndrome Patients. J Proteome Res. 2017 04 07; 16(4):1693-1705. PMID: 28282148.
      View in: PubMed
    8. Gormley M, Ona K, Kapidzic M, Garrido-Gomez T, Zdravkovic T, Fisher SJ. Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations. Am J Obstet Gynecol. 2017 08; 217(2):200.e1-200.e17. PMID: 28347715.
      View in: PubMed
    9. Muench MO, Kapidzic M, Gormley M, Gutierrez AG, Ponder KL, Fomin ME, Beyer AI, Stolp H, Qi Z, Fisher SJ, Bárcena A. The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation. Development. 2017 04 15; 144(8):1399-1411. PMID: 28255007.
      View in: PubMed
    10. Garrido-Gomez T, Ona K, Kapidzic M, Gormley M, Simón C, Genbacev O, Fisher SJ. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion. Development. 2017 03 01; 144(5):767-777. PMID: 28232601.
      View in: PubMed
    11. Slabodnick MM, Ruby JG, Reiff SB, Swart EC, Gosai S, Prabakaran S, Witkowska E, Larue GE, Fisher S, Freeman RM, Gunawardena J, Chu W, Stover NA, Gregory BD, Nowacki M, Derisi J, Roy SW, Marshall WF, Sood P. The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell. Curr Biol. 2017 Feb 20; 27(4):569-575. PMID: 28190732.
      View in: PubMed
    12. Bianco K, Gormley M, Farrell J, Zhou Y, Oliverio O, Tilden H, McMaster M, Fisher SJ. Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects. Prenat Diagn. 2016 Sep; 36(9):812-22. PMID: 27328057.
      View in: PubMed
    13. Lorenzon-Ojea AR, Guzzo CR, Kapidzic M, Fisher SJ, Bevilacqua E. Stromal Cell-Derived Factor 2: A Novel Protein that Interferes in Endoplasmic Reticulum Stress Pathway in Human Placental Cells. Biol Reprod. 2016 08; 95(2):41. PMID: 27335075.
      View in: PubMed
    14. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. 2016 11; 26(11):1222-1234. PMID: 27037304.
      View in: PubMed
    15. Ponder KL, Bárcena A, Bos FL, Gormley M, Zhou Y, Ona K, Kapidzic M, Zovein AC, Fisher SJ. Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche. Reprod Sci. 2016 09; 23(9):1179-92. PMID: 26944948.
      View in: PubMed
    16. Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z. Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1343-51. PMID: 26903627; PMCID: PMC4790982.
    17. Shatsky M, Allen S, Gold BL, Liu NL, Juba TR, Reveco SA, Elias DA, Prathapam R, He J, Yang W, Szakal ED, Liu H, Singer ME, Geller JT, Lam BR, Saini A, Trotter VV, Hall SC, Fisher SJ, Brenner SE, Chhabra SR, Hazen TC, Wall JD, Witkowska HE, Biggin MD, Chandonia JM, Butland G. Bacterial Interactomes: Interacting Protein Partners Share Similar Function and Are Validated in Independent Assays More Frequently Than Previously Reported. Mol Cell Proteomics. 2016 05; 15(5):1539-55. PMID: 26873250; PMCID: PMC4858938 [Available on 05/01/17].
    18. Albertolle ME, Hassis ME, Ng CJ, Cuison S, Williams K, Prakobphol A, Dykstra AB, Hall SC, Niles RK, Ewa Witkowska H, Fisher SJ. Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation. Clin Proteomics. 2015; 12:29. PMID: 26719750; PMCID: PMC4696288.
    19. Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ. Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification. Development. 2015 Dec 01; 142(23):4010-25. PMID: 26483210; PMCID: PMC4712832.
    20. Maltepe E, Fisher SJ. Placenta: the forgotten organ. Annu Rev Cell Dev Biol. 2015; 31:523-52. PMID: 26443191.
      View in: PubMed
    21. Fisher SJ. Why is placentation abnormal in preeclampsia? Am J Obstet Gynecol. 2015 Oct; 213(4 Suppl):S115-22. PMID: 26428489; PMCID: PMC4592742 [Available on 10/01/16].
    22. Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapiller N, Gnanaratnam G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, and Fisher SJ.Human Stem Cells from Single Blastomeres Reveal Pathways of Embryonic or Trophoblast Fate Specification (in Press). Development. 2015.
    23. Hassis ME, Niles RK, Braten MN, Albertolle ME, Ewa Witkowska H, Hubel CA, Fisher SJ, Williams KE. Evaluating the effects of preanalytical variables on the stability of the human plasma proteome. Anal Biochem. 2015 Jun 01; 478:14-22. PMID: 25769420; PMCID: PMC4492164.
    24. Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30. PMID: 25693563; PMCID: PMC4530010.
    25. Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA. Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma. Mol Cell Proteomics. 2015 Sep; 14(9):2357-74. PMID: 25693799; PMCID: PMC4563721.
    26. Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. .Roadmay Epigenomics Consortium: Integrative Analysis of 111 Reference Human Epigenomes. Nature. 2015; 518(19):317-330.
    27. Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice LC, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ. Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals. J Proteomics. 2015 Jan 15; 113:194-205. PMID: 25284053; PMCID: PMC4467531.
    28. Robinson JF, Fisher SJ. Rbpj links uterine transformation and embryo orientation. Cell Res. 2014 Sep; 24(9):1031-2. PMID: 25145360; PMCID: PMC4152736.
    29. Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014 Aug 15; 345(6198):760-5. PMID: 25124429.
      View in: PubMed
    30. Zawadzka AM, Schilling B, Held JM, Sahu AK, Cusack MP, Drake PM, Fisher SJ, Gibson BW. Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition. Electrophoresis. 2014 Dec; 35(24):3487-97. PMID: 24853916; PMCID: PMC4565165.
    31. Lorenzon-Ojea AR, Caldeira W, Ribeiro AF, Fisher SJ, Guzzo CR, Bevilacqua E. Stromal cell derived factor-2 (Sdf2): a novel protein expressed in mouse. Int J Biochem Cell Biol. 2014 Aug; 53:262-70. PMID: 24878610.
      View in: PubMed
    32. Zawadzka AM, Schilling B, Cusack MP, Sahu AK, Drake P, Fisher SJ, Benz CC, Gibson BW. Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma. Mol Cell Proteomics. 2014 Apr; 13(4):1034-49. PMID: 24505115; PMCID: PMC3977182.
    33. Zhou Y, Gormley MJ, Hunkapiller NM, Kapidzic M, Stolyarov Y, Feng V, Nishida M, Drake PM, Bianco K, Wang F, McMaster MT, Fisher SJ. Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia. J Clin Invest. 2013 Jul; 123(7):2862-72. PMID: 23934129; PMCID: PMC3999620.
    34. Co EC, Gormley M, Kapidzic M, Rosen DB, Scott MA, Stolp HA, McMaster M, Lanier LL, Bárcena A, Fisher SJ. Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy. Biol Reprod. 2013 Jun; 88(6):155. PMID: 23553431; PMCID: PMC4070869.
    35. Hromatka BS, Ngeleza S, Adibi JJ, Niles RK, Tshefu AK, Fisher SJ. Histopathologies, immunolocalization, and a glycan binding screen provide insights into Plasmodium falciparum interactions with the human placenta. Biol Reprod. 2013 Jun; 88(6):154. PMID: 23575149; PMCID: PMC4070867.
    36. Bartlett JA, Albertolle ME, Wohlford-Lenane C, Pezzulo AA, Zabner J, Niles RK, Fisher SJ, McCray PB, Williams KE. Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 01; 305(3):L256-66. PMID: 23709621; PMCID: PMC3743012.
    37. Abbatiello SE, Mani DR, Schilling B, Maclean B, Zimmerman LJ, Feng X, Cusack MP, Sedransk N, Hall SC, Addona T, Allen S, Dodder NG, Ghosh M, Held JM, Hedrick V, Inerowicz HD, Jackson A, Keshishian H, Kim JW, Lyssand JS, Riley CP, Rudnick P, Sadowski P, Shaddox K, Smith D, Tomazela D, Wahlander A, Waldemarson S, Whitwell CA, You J, Zhang S, Kinsinger CR, Mesri M, Rodriguez H, Borchers CH, Buck C, Fisher SJ, Gibson BW, Liebler D, Maccoss M, Neubert TA, Paulovich A, Regnier F, Skates SJ, Tempst P, Wang M, Carr SA. Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS). Mol Cell Proteomics. 2013 Sep; 12(9):2623-39. PMID: 23689285; PMCID: PMC3769335.
    38. Fisher SJ, Giudice LC. Retrospective. Robert G. Edwards (1925-2013). Science. 2013 May 17; 340(6134):825. PMID: 23687039.
      View in: PubMed
    39. Genbacev O, Lamb JD, Prakobphol A, Donne M, McMaster MT, Fisher SJ. Human trophoblast progenitors: where do they reside? Semin Reprod Med. 2013 Jan; 31(1):56-61. PMID: 23329637.
      View in: PubMed
    40. Drake P, Schilling B, Gibson B, Fisher S. Elucidation of N-glycosites within human plasma glycoproteins for cancer biomarker discovery. Methods Mol Biol. 2013; 951:307-22. PMID: 23296540.
      View in: PubMed
    41. Hromatka BS, Drake PM, Kapidzic M, Stolp H, Goldfien GA, Shih IeM, Fisher SJ. Polysialic acid enhances the migration and invasion of human cytotrophoblasts. Glycobiology. 2013 May; 23(5):593-602. PMID: 23208007; PMCID: PMC3608351.
    42. Walian PJ, Allen S, Shatsky M, Zeng L, Szakal ED, Liu H, Hall SC, Fisher SJ, Lam BR, Singer ME, Geller JT, Brenner SE, Chandonia JM, Hazen TC, Witkowska HE, Biggin MD, Jap BK. High-throughput isolation and characterization of untagged membrane protein complexes: outer membrane complexes of Desulfovibrio vulgaris. J Proteome Res. 2012 Dec 07; 11(12):5720-35. PMID: 23098413; PMCID: PMC3516867.
    43. Drake PM, Schilling B, Niles RK, Prakobphol A, Li B, Jung K, Cho W, Braten M, Inerowicz HD, Williams K, Albertolle M, Held JM, Iacovides D, Sorensen DJ, Griffith OL, Johansen E, Zawadzka AM, Cusack MP, Allen S, Gormley M, Hall SC, Witkowska HE, Gray JW, Regnier F, Gibson BW, Fisher SJ. Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers. J Proteome Res. 2012 Apr 06; 11(4):2508-20. PMID: 22309216; PMCID: PMC3383053.
    44. Aghajanova L, Shen S, Rojas AM, Fisher SJ, Irwin JC, Giudice LC. Comparative transcriptome analysis of human trophectoderm and embryonic stem cell-derived trophoblasts reveal key participants in early implantation. Biol Reprod. 2012 Jan; 86(1):1-21. PMID: 21865555.
      View in: PubMed
    45. Witkowska HE, Hall SC, Fisher SJ. Breaking the bottleneck in the protein biomarker pipeline. Clin Chem. 2012 Feb; 58(2):321-3. PMID: 22140214.
      View in: PubMed
    46. Fisher SJ, Giudice LC. SGK1: a fine balancing act for human pregnancy. Nat Med. 2011 Nov 07; 17(11):1348-9. PMID: 22064410.
      View in: PubMed
    47. Bárcena A, Muench MO, Kapidzic M, Gormley M, Goldfien GA, Fisher SJ. Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation. Transfusion. 2011 Nov; 51 Suppl 4:94S-105S. PMID: 22074633; PMCID: PMC3266842.
    48. Genbacev O, Donne M, Kapidzic M, Gormley M, Lamb J, Gilmore J, Larocque N, Goldfien G, Zdravkovic T, McMaster MT, Fisher SJ. Establishment of human trophoblast progenitor cell lines from the chorion. Stem Cells. 2011 Sep; 29(9):1427-36. PMID: 21755573; PMCID: PMC3345889.
    49. Liu H, Yang L, Khainovski N, Dong M, Hall SC, Fisher SJ, Biggin MD, Jin J, Witkowska HE. Automated iterative MS/MS acquisition: a tool for improving efficiency of protein identification using a LC-MALDI MS workflow. Anal Chem. 2011 Aug 15; 83(16):6286-93. PMID: 21761829.
      View in: PubMed
    50. Hunkapiller NM, Gasperowicz M, Kapidzic M, Plaks V, Maltepe E, Kitajewski J, Cross JC, Fisher SJ. A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia. Development. 2011 Jul; 138(14):2987-98. PMID: 21693515; PMCID: PMC3119307.
    51. Schanz A, Winn VD, Fisher SJ, Blumenstein M, Heiss C, Hess AP, Kruessel JS, Mcmaster M, North RA. Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood. Eur J Obstet Gynecol Reprod Biol. 2011 Jul; 157(1):32-7. PMID: 21450389.
      View in: PubMed
    52. Krtolica A, Larocque N, Genbacev O, Ilic D, Coppe JP, Patil CK, Zdravkovic T, McMaster M, Campisi J, Fisher SJ. GROa regulates human embryonic stem cell self-renewal or adoption of a neuronal fate. Differentiation. 2011 Apr; 81(4):222-32. PMID: 21396766.
      View in: PubMed
    53. Marchand M, Horcajadas JA, Esteban FJ, McElroy SL, Fisher SJ, Giudice LC. Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model. Biol Reprod. 2011 Jun; 84(6):1258-71. PMID: 21368299.
      View in: PubMed
    54. Winn VD, Gormley M, Fisher SJ. The Impact of Preeclampsia on Gene Expression at the Maternal-Fetal Interface. Pregnancy Hypertens. 2011 Jan 01; 1(1):100-8. PMID: 21743843.
      View in: PubMed
    55. Roberts RM, Fisher SJ. Trophoblast stem cells. Biol Reprod. 2011 Mar; 84(3):412-21. PMID: 21106963; PMCID: PMC3043125.
    56. Drake PM, Schilling B, Niles RK, Braten M, Johansen E, Liu H, Lerch M, Sorensen DJ, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ. A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma. Anal Biochem. 2011 Jan 01; 408(1):71-85. PMID: 20705048; PMCID: PMC3205961.
    57. Maltepe E, Bakardjiev AI, Fisher SJ. The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest. 2010 Apr; 120(4):1016-25. PMID: 20364099; PMCID: PMC2846055.
    58. Lo B, Parham L, Cedars M, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Rao R, Roberts C, Wagner R. Research ethics. NIH guidelines for stem cell research and gamete donors. Science. 2010 Feb 19; 327(5968):962-3. PMID: 20167773; PMCID: PMC2892655.
    59. Tabb DL, Vega-Montoto L, Rudnick PA, Variyath AM, Ham AJ, Bunk DM, Kilpatrick LE, Billheimer DD, Blackman RK, Cardasis HL, Carr SA, Clauser KR, Jaffe JD, Kowalski KA, Neubert TA, Regnier FE, Schilling B, Tegeler TJ, Wang M, Wang P, Whiteaker JR, Zimmerman LJ, Fisher SJ, Gibson BW, Kinsinger CR, Mesri M, Rodriguez H, Stein SE, Tempst P, Paulovich AG, Liebler DC, Spiegelman C. Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry. J Proteome Res. 2010 Feb 05; 9(2):761-76. PMID: 19921851; PMCID: PMC2818771.
    60. Lo B, Parham L, Alvarez-Buylla A, Cedars M, Conklin B, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Wagner R. Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning. Cell Stem Cell. 2010 Jan 08; 6(1):16-20. PMID: 20085739; PMCID: PMC4035242.
    61. Rodriguez H, Tezak Z, Mesri M, Carr SA, Liebler DC, Fisher SJ, Tempst P, Hiltke T, Kessler LG, Kinsinger CR, Philip R, Ransohoff DF, Skates SJ, Regnier FE, Anderson NL, Mansfield E. Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics. Clin Chem. 2010 Feb; 56(2):237-43. PMID: 20007859.
      View in: PubMed
    62. Regnier FE, Skates SJ, Mesri M, Rodriguez H, Tezak Z, Kondratovich MV, Alterman MA, Levin JD, Roscoe D, Reilly E, Callaghan J, Kelm K, Brown D, Philip R, Carr SA, Liebler DC, Fisher SJ, Tempst P, Hiltke T, Kessler LG, Kinsinger CR, Ransohoff DF, Mansfield E, Anderson NL. Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration. Clin Chem. 2010 Feb; 56(2):165-71. PMID: 20007858.
      View in: PubMed
    63. Drake PM, Cho W, Li B, Prakobphol A, Johansen E, Anderson NL, Regnier FE, Gibson BW, Fisher SJ. Sweetening the pot: adding glycosylation to the biomarker discovery equation. Clin Chem. 2010 Feb; 56(2):223-36. PMID: 19959616; PMCID: PMC2849286.
    64. Ilic D, Giritharan G, Zdravkovic T, Caceres E, Genbacev O, Fisher SJ, Krtolica A. Derivation of human embryonic stem cell lines from biopsied blastomeres on human feeders with minimal exposure to xenomaterials. Stem Cells Dev. 2009 Nov; 18(9):1343-50. PMID: 19222349.
      View in: PubMed
    65. Paulovich AG, Billheimer D, Ham AJ, Vega-Montoto L, Rudnick PA, Tabb DL, Wang P, Blackman RK, Bunk DM, Cardasis HL, Clauser KR, Kinsinger CR, Schilling B, Tegeler TJ, Variyath AM, Wang M, Whiteaker JR, Zimmerman LJ, Fenyo D, Carr SA, Fisher SJ, Gibson BW, Mesri M, Neubert TA, Regnier FE, Rodriguez H, Spiegelman C, Stein SE, Tempst P, Liebler DC. Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance. Mol Cell Proteomics. 2010 Feb; 9(2):242-54. PMID: 19858499; PMCID: PMC2830837.
    66. Rudnick PA, Clauser KR, Kilpatrick LE, Tchekhovskoi DV, Neta P, Blonder N, Billheimer DD, Blackman RK, Bunk DM, Cardasis HL, Ham AJ, Jaffe JD, Kinsinger CR, Mesri M, Neubert TA, Schilling B, Tabb DL, Tegeler TJ, Vega-Montoto L, Variyath AM, Wang M, Wang P, Whiteaker JR, Zimmerman LJ, Carr SA, Fisher SJ, Gibson BW, Paulovich AG, Regnier FE, Rodriguez H, Spiegelman C, Tempst P, Liebler DC, Stein SE. Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses. Mol Cell Proteomics. 2010 Feb; 9(2):225-41. PMID: 19837981; PMCID: PMC2830836.
    67. Johansen E, Schilling B, Lerch M, Niles RK, Liu H, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ, Drake PM. A lectin HPLC method to enrich selectively-glycosylated peptides from complex biological samples. J Vis Exp. 2009 Oct 01; (32). PMID: 19798022; PMCID: PMC2762330.
    68. Addona TA, Abbatiello SE, Schilling B, Skates SJ, Mani DR, Bunk DM, Spiegelman CH, Zimmerman LJ, Ham AJ, Keshishian H, Hall SC, Allen S, Blackman RK, Borchers CH, Buck C, Cardasis HL, Cusack MP, Dodder NG, Gibson BW, Held JM, Hiltke T, Jackson A, Johansen EB, Kinsinger CR, Li J, Mesri M, Neubert TA, Niles RK, Pulsipher TC, Ransohoff D, Rodriguez H, Rudnick PA, Smith D, Tabb DL, Tegeler TJ, Variyath AM, Vega-Montoto LJ, Wahlander A, Waldemarson S, Wang M, Whiteaker JR, Zhao L, Anderson NL, Fisher SJ, Liebler DC, Paulovich AG, Regnier FE, Tempst P, Carr SA. Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol. 2009 Jul; 27(7):633-41. PMID: 19561596; PMCID: PMC2855883.
    69. Zhou J, Su P, Wang L, Chen J, Zimmermann M, Genbacev O, Afonja O, Horne MC, Tanaka T, Duan E, Fisher SJ, Liao J, Chen J, Wang F. mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7840-5. PMID: 19416884; PMCID: PMC2683106.
    70. Niles R, Witkowska HE, Allen S, Hall SC, Fisher SJ, Hardt M. Acid-catalyzed oxygen-18 labeling of peptides. Anal Chem. 2009 Apr 01; 81(7):2804-9. PMID: 19243188; PMCID: PMC2892872.
    71. Bárcena A, Muench MO, Kapidzic M, Fisher SJ. A new role for the human placenta as a hematopoietic site throughout gestation. Reprod Sci. 2009 Feb; 16(2):178-87. PMID: 19208786; PMCID: PMC2731631.
    72. Bárcena A, Kapidzic M, Muench MO, Gormley M, Scott MA, Weier JF, Ferlatte C, Fisher SJ. The human placenta is a hematopoietic organ during the embryonic and fetal periods of development. Dev Biol. 2009 Mar 01; 327(1):24-33. PMID: 19073167; PMCID: PMC2668662.
    73. Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, Oxvig C, Fisher SJ. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology. 2009 Jan; 150(1):452-62. PMID: 18818296; PMCID: PMC2630905.
    74. Zdravkovic T, Genbacev O, LaRocque N, McMaster M, Fisher S. Human embryonic stem cells as a model system for studying the effects of smoke exposure on the embryo. Reprod Toxicol. 2008 Oct; 26(2):86-93. PMID: 18692565.
      View in: PubMed
    75. Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR, Fisher SJ. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res. 2008 May; 7(5):1994-2006. PMID: 18361515; PMCID: PMC2839126.
    76. Dong M, Yang LL, Williams K, Fisher SJ, Hall SC, Biggin MD, Jin J, Witkowska HE. A "tagless" strategy for identification of stable protein complexes genome-wide by multidimensional orthogonal chromatographic separation and iTRAQ reagent tracking. J Proteome Res. 2008 May; 7(5):1836-49. PMID: 18336004.
      View in: PubMed
    77. Robinson S, Niles RK, Witkowska HE, Rittenbach KJ, Nichols RJ, Sargent JA, Dixon SE, Prakobphol A, Hall SC, Fisher SJ, Hardt M. A mass spectrometry-based strategy for detecting and characterizing endogenous proteinase activities in complex biological samples. Proteomics. 2008 Feb; 8(3):435-45. PMID: 18186022.
      View in: PubMed
    78. Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008 Jan 18; 29(1):9-22. PMID: 18206965; PMCID: PMC2234035.
    79. Chung Y, Klimanskaya I, Becker S, Li T, Maserati M, Lu SJ, Zdravkovic T, Ilic D, Genbacev O, Fisher S, Krtolica A, Lanza R. Human embryonic stem cell lines generated without embryo destruction. Cell Stem Cell. 2008 Feb 07; 2(2):113-7. PMID: 18371431.
      View in: PubMed
    80. Hunkapiller NM, Fisher SJ. Chapter 12. Placental remodeling of the uterine vasculature. Methods Enzymol. 2008; 445:281-302. PMID: 19022064; PMCID: PMC2857511.
    81. Krtolica A, Genbacev O, Escobedo C, Zdravkovic T, Nordstrom A, Vabuena D, Nath A, Simon C, Mostov K, Fisher SJ. Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation. Stem Cells. 2007 Sep; 25(9):2215-23. PMID: 17569786.
      View in: PubMed
    82. Zhou Y, Bianco K, Huang L, Nien JK, McMaster M, Romero R, Fisher SJ. Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor. Cell Tissue Res. 2007 Sep; 329(3):559-69. PMID: 17549520.
      View in: PubMed
    83. Ilic D, Mao-Qiang M, Crumrine D, Dolganov G, Larocque N, Xu P, Demerjian M, Brown BE, Lim ST, Ossovskaya V, Schlaepfer DD, Fisher SJ, Feingold KR, Elias PM, Mauro TM. Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. Am J Pathol. 2007 Jun; 170(6):2055-67. PMID: 17525272; PMCID: PMC1899430.
    84. Winn VD, Haimov-Kochman R, Paquet AC, Yang YJ, Madhusudhan MS, Gormley M, Feng KT, Bernlohr DA, McDonagh S, Pereira L, Sali A, Fisher SJ. Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term. Endocrinology. 2007 Mar; 148(3):1059-79. PMID: 17170095.
      View in: PubMed
    85. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Oct; 116(10):2643-52. PMID: 16998586; PMCID: PMC1570373.
    86. Carson DD, Julian J, Lessey BA, Prakobphol A, Fisher SJ. MUC1 is a scaffold for selectin ligands in the human uterus. Front Biosci. 2006 Sep 01; 11:2903-8. PMID: 16720361.
      View in: PubMed
    87. Zdravkovic T, Genbacev O, Prakobphol A, Cvetkovic M, Schanz A, McMaster M, Fisher SJ. Nicotine downregulates the l-selectin system that mediates cytotrophoblast emigration from cell columns and attachment to the uterine wall. Reprod Toxicol. 2006 Jul; 22(1):69-76. PMID: 16806808.
      View in: PubMed
    88. Prakobphol A, Genbacev O, Gormley M, Kapidzic M, Fisher SJ. A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta. Dev Biol. 2006 Oct 01; 298(1):107-17. PMID: 16930583.
      View in: PubMed
    89. Takamatsu D, Bensing BA, Prakobphol A, Fisher SJ, Sullam PM. Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins. Infect Immun. 2006 Mar; 74(3):1933-40. PMID: 16495569; PMCID: PMC1418684.
    90. Haimov-Kochman R, Fisher SJ, Winn VD. Modification of the standard Trizol-based technique improves the integrity of RNA isolated from RNase-rich placental tissue. Clin Chem. 2006 Jan; 52(1):159-60. PMID: 16391340.
      View in: PubMed
    91. Red-Horse K, Kapidzic M, Zhou Y, Feng KT, Singh H, Fisher SJ. EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation. Development. 2005 Sep; 132(18):4097-106. PMID: 16107476.
      View in: PubMed
    92. Hardt M, Witkowska HE, Webb S, Thomas LR, Dixon SE, Hall SC, Fisher SJ. Assessing the effects of diurnal variation on the composition of human parotid saliva: quantitative analysis of native peptides using iTRAQ reagents. Anal Chem. 2005 Aug 01; 77(15):4947-54. PMID: 16053308.
      View in: PubMed
    93. Genbacev-Krtolica O. Highlight for phenols, quinolines, indoles, benzene and 2-cyclopenten-1-ones are oviduct toxicants in cigarette smoke, by Prue Talbot, Karen Riveles, and Ryan Rosa: list of tobacco-smoke constituents that are harmful for reproduction grows--passive smokers may be at risk. Toxicol Sci. 2005 Jul; 86(1):4-5. PMID: 16003830.
      View in: PubMed
    94. Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development. 2005 Aug; 132(15):3393-403. PMID: 15987772.
      View in: PubMed
    95. Genbacev O, Krtolica A, Zdravkovic T, Brunette E, Powell S, Nath A, Caceres E, McMaster M, McDonagh S, Li Y, Mandalam R, Lebkowski J, Fisher SJ. Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders. Fertil Steril. 2005 May; 83(5):1517-29. PMID: 15866593.
      View in: PubMed
    96. Weier JF, Weier HU, Jung CJ, Gormley M, Zhou Y, Chu LW, Genbacev O, Wright AA, Fisher SJ. Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype. Dev Biol. 2005 Mar 15; 279(2):420-32. PMID: 15733669.
      View in: PubMed
    97. Hardt M, Thomas LR, Dixon SE, Newport G, Agabian N, Prakobphol A, Hall SC, Witkowska HE, Fisher SJ. Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry. 2005 Mar 01; 44(8):2885-99. PMID: 15723531.
      View in: PubMed
    98. Prakobphol A, Borén T, Ma W, Zhixiang P, Fisher SJ. Highly glycosylated human salivary molecules present oligosaccharides that mediate adhesion of leukocytes and Helicobacter pylori. Biochemistry. 2005 Feb 15; 44(6):2216-24. PMID: 15697247.
      View in: PubMed
    99. Simón C, Escobedo C, Valbuena D, Genbacev O, Galan A, Krtolica A, Asensi A, Sánchez E, Esplugues J, Fisher S, Pellicer A. First derivation in Spain of human embryonic stem cell lines: use of long-term cryopreserved embryos and animal-free conditions. Fertil Steril. 2005 Jan; 83(1):246-9. PMID: 15652923.
      View in: PubMed
    100. Wright A, Zhou Y, Weier JF, Caceres E, Kapidzic M, Tabata T, Kahn M, Nash C, Fisher SJ. Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway. Am J Med Genet A. 2004 Nov 01; 130A(4):354-64. PMID: 15389712.
      View in: PubMed
    101. McMaster MT, Zhou Y, Fisher SJ. Abnormal placentation and the syndrome of preeclampsia. Semin Nephrol. 2004 Nov; 24(6):540-7. PMID: 15529288.
      View in: PubMed
    102. Chénais B, Derjuga A, Massrieh W, Red-Horse K, Bellingard V, Fisher SJ, Blank V. Functional and placental expression analysis of the human NRF3 transcription factor. Mol Endocrinol. 2005 Jan; 19(1):125-37. PMID: 15388789.
      View in: PubMed
    103. Red-Horse K, Zhou Y, Genbacev O, Prakobphol A, Foulk R, McMaster M, Fisher SJ. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest. 2004 Sep; 114(6):744-54. PMID: 15372095; PMCID: PMC516273.
    104. McDonagh S, Maidji E, Ma W, Chang HT, Fisher S, Pereira L. Viral and bacterial pathogens at the maternal-fetal interface. J Infect Dis. 2004 Aug 15; 190(4):826-34. PMID: 15272412.
      View in: PubMed
    105. Fisher SJ. The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol. 2004 Jul 05; 2:53. PMID: 15236649; PMCID: PMC493282.
    106. Red-Horse K, Drake PM, Fisher SJ. Human pregnancy: the role of chemokine networks at the fetal-maternal interface. Expert Rev Mol Med. 2004 May 10; 6(11):1-14. PMID: 15130179.
      View in: PubMed
    107. Drake PM, Red-Horse K, Fisher SJ. Reciprocal chemokine receptor and ligand expression in the human placenta: implications for cytotrophoblast differentiation. Dev Dyn. 2004 Apr; 229(4):877-85. PMID: 15042711.
      View in: PubMed
    108. Yamamoto-Tabata T, McDonagh S, Chang HT, Fisher S, Pereira L. Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro. J Virol. 2004 Mar; 78(6):2831-40. PMID: 14990702; PMCID: PMC353759.
    109. Bakardjiev AI, Stacy BA, Fisher SJ, Portnoy DA. Listeriosis in the pregnant guinea pig: a model of vertical transmission. Infect Immun. 2004 Jan; 72(1):489-97. PMID: 14688130; PMCID: PMC343973.
    110. Pereira L, Maidji E, McDonagh S, Genbacev O, Fisher S. Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity. J Virol. 2003 Dec; 77(24):13301-14. PMID: 14645586; PMCID: PMC296088.
    111. Zhou Y, Bellingard V, Feng KT, McMaster M, Fisher SJ. Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C. Dev Biol. 2003 Nov 01; 263(1):114-25. PMID: 14568550.
      View in: PubMed
    112. Genbacev O, McMaster MT, Zdravkovic T, Fisher SJ. Disruption of oxygen-regulated responses underlies pathological changes in the placentas of women who smoke or who are passively exposed to smoke during pregnancy. Reprod Toxicol. 2003 Sep-Oct; 17(5):509-18. PMID: 14555188.
      View in: PubMed
    113. Zhou Y, Genbacev O, Fisher SJ. The human placenta remodels the uterus by using a combination of molecules that govern vasculogenesis or leukocyte extravasation. Ann N Y Acad Sci. 2003 May; 995:73-83. PMID: 12814940.
      View in: PubMed
    114. Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, Yang ZQ, Kiessling LL, Rosen SD, Fisher SJ. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003 Jan 17; 299(5605):405-8. PMID: 12532021.
      View in: PubMed
    115. Taylor RN, Grimwood J, Taylor RS, McMaster MT, Fisher SJ, North RA. Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies. Am J Obstet Gynecol. 2003 Jan; 188(1):177-82. PMID: 12548214.
      View in: PubMed
    116. Maidji E, Percivalle E, Gerna G, Fisher S, Pereira L. Transmission of human cytomegalovirus from infected uterine microvascular endothelial cells to differentiating/invasive placental cytotrophoblasts. Virology. 2002 Dec 05; 304(1):53-69. PMID: 12490403.
      View in: PubMed
    117. Drake PM, Red-Horse K, Fisher SJ. Chemokine expression and function at the human maternal-fetal interface. Rev Endocr Metab Disord. 2002 May; 3(2):159-65. PMID: 12007293.
      View in: PubMed
    118. Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002 Apr; 160(4):1405-23. PMID: 11943725; PMCID: PMC3277330.
    119. Thomsson KA, Prakobphol A, Leffler H, Reddy MS, Levine MJ, Fisher SJ, Hansson GC. The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology. 2002 Jan; 12(1):1-14. PMID: 11825880.
      View in: PubMed
    120. Paul P, Rouas-Freiss N, Moreau P, Cabestre FA, Menier C, Khalil-Daher I, Pangault C, Onno M, Fauchet R, Martinez-Laso J, Morales P, Villena AA, Giacomini P, Natali PG, Frumento G, Ferrara GB, McMaster M, Fisher S, Schust D, Ferrone S, Dausset J, Geraghty D, Carosella ED. HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression. Hum Immunol. 2000 Nov; 61(11):1177-95. PMID: 11137224.
      View in: PubMed
    121. Goldman-Wohl DS, Ariel I, Greenfield C, Hochner-Celnikier D, Cross J, Fisher S, Yagel S. Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia. Mol Hum Reprod. 2000 Jan; 6(1):88-95. PMID: 10611266.
      View in: PubMed
    122. Rohde LH, Janatpore MJ, McMaster MT, Fisher S, Zhou Y, Lim KH, French M, Hoke D, Julian J, Carson DD. Complementary expression of HIP, a cell-surface heparan sulfate binding protein, and perlecan at the human fetal-maternal interface. Biol Reprod. 1998 Apr; 58(4):1075-83. PMID: 9546743.
      View in: PubMed
    123. Azen EA, Amberger E, Fisher S, Prakobphol A, Niece RL. PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins. Am J Hum Genet. 1996 Jan; 58(1):143-53. PMID: 8554050; PMCID: PMC1914931.
    124. Fisher SJ, Damsky CH. Human cytotrophoblast invasion. Semin Cell Biol. 1993 Jun; 4(3):183-8. PMID: 8347835.
      View in: PubMed
    125. Zhu BC, Fisher SF, Pande H, Calaycay J, Shively JE, Laine RA. Human placental (fetal) fibronectin: increased glycosylation and higher protease resistance than plasma fibronectin. Presence of polylactosamine glycopeptides and properties of a 44-kilodalton chymotryptic collagen-binding domain: difference from human plasma fibronectin. J Biol Chem. 1984 Mar 25; 259(6):3962-70. PMID: 6423638.
      View in: PubMed
    126. Fisher SJ, Laine RA. Carbohydrate structure of the major glycopeptide from human cold-insoluble globulin. J Supramol Struct. 1979; 11(3):391-9. PMID: 120906.
      View in: PubMed
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