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Paul Sullam, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
AddressVAMC 1
San Francisco CA 94121
Phone415-221-4810 ext. 2550
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1985 Medicine
    University of California, San Francisco Clinical Fellowship
    University of California, San FranciscoResidency

    Collapse Research 
    Collapse Research Activities and Funding
    HARNESSING THE ORAL MICROBIOME TO CREATE NOVEL GLYCAN-BINDING PROBES
    NIH/NCI U01CA221244Aug 16, 2017 - Jul 31, 2020
    Role: Co-Principal Investigator
    MINING THE ORAL MICROBIOME FOR NOVEL GLYCAN-BINDING MOLECULES
    NIH/NIDCR R21DE025826Aug 5, 2015 - Jul 31, 2017
    Role: Co-Principal Investigator
    Mechanisms for ligand binding by serine-rich adhesins of Gram-positive pathogens
    NIH/NIAID R01AI106987Jul 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    The accessory Sec system of Gram-positive pathogens
    VA I01BX001653Oct 1, 2012 - Sep 30, 2016
    Role: Principal Investigator
    Prophage-Encoded Binding of S. mitis to Human Platelets
    NIH/NIAID R01AI057433Aug 1, 2004 - Jan 31, 2010
    Role: Principal Investigator
    Role of Streptococcal-Platelet Binding in Endocarditis
    NIH/NIAID R01AI041513Jul 1, 1997 - Nov 30, 2019
    Role: Principal Investigator
    MECHANISMS OF PLATELET BINDING BY VIRIDANS STREPTOCOCCI
    NIH/NIAID R29AI032506Jul 1, 1992 - Jun 30, 1998
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bensing BA, Li Q, Park D, Lebrilla CB, Sullam P. Streptococcal Siglec-like Adhesins Recognize Different Subsets of Human Plasma Glycoproteins: Implications for Infective Endocarditis. Glycobiology. 2018 May 23. PMID: 29796594.
      View in: PubMed
    2. Yakovenko O, Nunez J, Bensing B, Yu H, Mount J, Zeng J, Hawkins J, Chen X, Sullam P, Thomas W. SRR Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets. Infect Immun. 2018 Mar 26. PMID: 29581195.
      View in: PubMed
    3. Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam P, Rapoport TA. Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. J Biol Chem. 2018 Feb 09. PMID: 29462788.
      View in: PubMed
    4. Lin SM, Jang AY, Zhi Y, Gao S, Lim S, Lim JH, Song JY, Sullam P, Rhee JH, Seo HS. Vaccination With a Latch Peptide Provides Serotype-Independent Protection Against Group B Streptococcus Infection in Mice. J Infect Dis. 2017 Dec 27; 217(1):93-102. PMID: 29106586.
      View in: PubMed
    5. Seepersaud R, Sychantha D, Bensing BA, Clarke AJ, Sullam P. O-acetylation of the serine-rich repeat glycoprotein GspB is coordinated with accessory Sec transport. PLoS Pathog. 2017 Aug; 13(8):e1006558. PMID: 28827841.
      View in: PubMed
    6. Yim J, Smith JR, Singh NB, Rice S, Stamper K, Garcia de la Maria C, Bayer AS, Mishra NN, Miró JM, Tran TT, Arias CA, Sullam P, Rybak MJ. Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs). J Antimicrob Chemother. 2017 Aug 01; 72(8):2290-2296. PMID: 28475731.
      View in: PubMed
    7. Mishra NN, Tran TT, Seepersaud R, Garcia-de-la-Maria C, Faull K, Yoon A, Proctor R, Miro JM, Rybak MJ, Bayer AS, Arias CA, Sullam P. Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism. Antimicrob Agents Chemother. 2017 04; 61(4). PMID: 28115347.
      View in: PubMed
    8. Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam P, Iverson TM. Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. Biochemistry. 2016 Oct 11. PMID: 27685666.
      View in: PubMed
    9. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam P. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. 2016 11; 26(11):1222-1234. PMID: 27037304.
      View in: PubMed
    10. Chen Y, Seepersaud R, Bensing BA, Sullam P, Rapoport TA. Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1190-9. PMID: 26884191; PMCID: PMC4780648.
    11. Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam P, Iverson TM. Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J Biol Chem. 2016 Apr 01; 291(14):7230-40. PMID: 26833566; PMCID: PMC4817157 [Available on 04/01/17].
    12. Deng L, Bensing BA, Thamadilok S, Yu H, Lau K, Chen X, Ruhl S, Sullam P, Varki A. Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood. PLoS Pathog. 2014 Dec; 10(12):e1004540. PMID: 25474103; PMCID: PMC4256463.
    13. Wang NY, Patras KA, Seo HS, Cavaco CK, Rösler B, Neely MN, Sullam P, Doran KS. Group B streptococcal serine-rich repeat proteins promote interaction with fibrinogen and vaginal colonization. J Infect Dis. 2014 Sep 15; 210(6):982-91. PMID: 24620021; PMCID: PMC4192050.
    14. Bensing BA, Seepersaud R, Yen YT, Sullam P. Selective transport by SecA2: an expanding family of customized motor proteins. Biochim Biophys Acta. 2014 Aug; 1843(8):1674-86. PMID: 24184206; PMCID: PMC4007388.
    15. Seo HS, Minasov G, Seepersaud R, Doran KS, Dubrovska I, Shuvalova L, Anderson WF, Iverson TM, Sullam P. Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae. J Biol Chem. 2013 Dec 13; 288(50):35982-96. PMID: 24165132; PMCID: PMC3861647.
    16. Seo HS, Xiong YQ, Sullam P. Role of the serine-rich surface glycoprotein Srr1 of Streptococcus agalactiae in the pathogenesis of infective endocarditis. PLoS One. 2013; 8(5):e64204. PMID: 23717569; PMCID: PMC3662765.
    17. Yen YT, Cameron TA, Bensing BA, Seepersaud R, Zambryski PC, Sullam P. Differential localization of the streptococcal accessory sec components and implications for substrate export. J Bacteriol. 2013 Feb; 195(4):682-95. PMID: 23204472; PMCID: PMC3562102.
    18. Seo HS, Mu R, Kim BJ, Doran KS, Sullam P. Binding of glycoprotein Srr1 of Streptococcus agalactiae to fibrinogen promotes attachment to brain endothelium and the development of meningitis. PLoS Pathog. 2012; 8(10):e1002947. PMID: 23055927; PMCID: PMC3464228.
    19. Seepersaud R, Bensing BA, Yen YT, Sullam P. The accessory Sec protein Asp2 modulates GlcNAc deposition onto the serine-rich repeat glycoprotein GspB. J Bacteriol. 2012 Oct; 194(20):5564-75. PMID: 22885294; PMCID: PMC3458669.
    20. Bensing BA, Yen YT, Seepersaud R, Sullam P. A Specific interaction between SecA2 and a region of the preprotein adjacent to the signal peptide occurs during transport via the accessory Sec system. J Biol Chem. 2012 Jul 13; 287(29):24438-47. PMID: 22654116; PMCID: PMC3397869.
    21. Baum PD, Sullam P, Stoddart CA, McCune JM. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28; 25(18):2243-8. PMID: 21941165; PMCID: PMC3272328.
    22. Pyburn TM, Bensing BA, Xiong YQ, Melancon BJ, Tomasiak TM, Ward NJ, Yankovskaya V, Oliver KM, Cecchini G, Sulikowski GA, Tyska MJ, Sullam P, Iverson TM. A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. PLoS Pathog. 2011 Jul; 7(7):e1002112. PMID: 21765814; PMCID: PMC3131266.
    23. Seo HS, Sullam P. Characterization of the fibrinogen binding domain of bacteriophage lysin from Streptococcus mitis. Infect Immun. 2011 Sep; 79(9):3518-26. PMID: 21690235; PMCID: PMC3165489.
    24. Yen YT, Seepersaud R, Bensing BA, Sullam P. Asp2 and Asp3 interact directly with GspB, the export substrate of the Streptococcus gordonii accessory Sec System. J Bacteriol. 2011 Jul; 193(13):3165-74. PMID: 21531800; PMCID: PMC3133275.
    25. Nallapareddy SR, Sillanpää J, Mitchell J, Singh KV, Chowdhury SA, Weinstock GM, Sullam P, Murray BE. Conservation of Ebp-type pilus genes among Enterococci and demonstration of their role in adherence of Enterococcus faecalis to human platelets. Infect Immun. 2011 Jul; 79(7):2911-20. PMID: 21502588; PMCID: PMC3191956.
    26. Pyburn TM, Yankovskaya V, Bensing BA, Cecchini G, Sullam P, Iverson TM. Purification, crystallization and preliminary X-ray diffraction analysis of the carbohydrate-binding region of the Streptococcus gordonii adhesin GspB. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 01; 66(Pt 11):1503-7. PMID: 21045307; PMCID: PMC3001660.
    27. Seepersaud R, Bensing BA, Yen YT, Sullam P. Asp3 mediates multiple protein-protein interactions within the accessory Sec system of Streptococcus gordonii. Mol Microbiol. 2010 Oct; 78(2):490-505. PMID: 20807195; PMCID: PMC2959127.
    28. Sanchez CJ, Shivshankar P, Stol K, Trakhtenbroit S, Sullam P, Sauer K, Hermans PW, Orihuela CJ. The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms. PLoS Pathog. 2010 Aug 12; 6(8):e1001044. PMID: 20714350; PMCID: PMC2920850.
    29. Seo HS, Xiong YQ, Mitchell J, Seepersaud R, Bayer AS, Sullam P. Bacteriophage lysin mediates the binding of streptococcus mitis to human platelets through interaction with fibrinogen. PLoS Pathog. 2010 Aug 12; 6(8):e1001047. PMID: 20714354; PMCID: PMC2920869.
    30. Bensing BA, Sullam P. Transport of preproteins by the accessory Sec system requires a specific domain adjacent to the signal peptide. J Bacteriol. 2010 Aug; 192(16):4223-32. PMID: 20562303; PMCID: PMC2916413.
    31. Miragaia M, de Lencastre H, Perdreau-Remington F, Chambers HF, Higashi J, Sullam P, Lin J, Wong KI, King KA, Otto M, Sensabaugh GF, Diep BA. Genetic diversity of arginine catabolic mobile element in Staphylococcus epidermidis. PLoS One. 2009 Nov 06; 4(11):e7722. PMID: 19893740; PMCID: PMC2768820.
    32. Mitchell J, Sullam P. Streptococcus mitis phage-encoded adhesins mediate attachment to {alpha}2-8-linked sialic acid residues on platelet membrane gangliosides. Infect Immun. 2009 Aug; 77(8):3485-90. PMID: 19506011; PMCID: PMC2715653.
    33. van Sorge NM, Quach D, Gurney MA, Sullam P, Nizet V, Doran KS. The group B streptococcal serine-rich repeat 1 glycoprotein mediates penetration of the blood-brain barrier. J Infect Dis. 2009 May 15; 199(10):1479-87. PMID: 19392623; PMCID: PMC2674616.
    34. Bensing BA, Sullam P. Characterization of Streptococcus gordonii SecA2 as a paralogue of SecA. J Bacteriol. 2009 Jun; 191(11):3482-91. PMID: 19363114; PMCID: PMC2681895.
    35. Siboo IR, Chaffin DO, Rubens CE, Sullam P. Characterization of the accessory Sec system of Staphylococcus aureus. J Bacteriol. 2008 Sep; 190(18):6188-96. PMID: 18621893; PMCID: PMC2546797.
    36. Xiong YQ, Bensing BA, Bayer AS, Chambers HF, Sullam P. Role of the serine-rich surface glycoprotein GspB of Streptococcus gordonii in the pathogenesis of infective endocarditis. Microb Pathog. 2008 Oct; 45(4):297-301. PMID: 18656529; PMCID: PMC2574613.
    37. Mitchell J, Siboo IR, Takamatsu D, Chambers HF, Sullam P. Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB. Mol Microbiol. 2007 May; 64(3):844-57. PMID: 17462028.
      View in: PubMed
    38. Bensing BA, Siboo IR, Sullam P. Glycine residues in the hydrophobic core of the GspB signal sequence route export toward the accessory Sec pathway. J Bacteriol. 2007 May; 189(10):3846-54. PMID: 17369296; PMCID: PMC1913339.
    39. Takamatsu D, Bensing BA, Prakobphol A, Fisher SJ, Sullam P. Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins. Infect Immun. 2006 Mar; 74(3):1933-40. PMID: 16495569; PMCID: PMC1418684.
    40. Bensing BA, Takamatsu D, Sullam P. Determinants of the streptococcal surface glycoprotein GspB that facilitate export by the accessory Sec system. Mol Microbiol. 2005 Dec; 58(5):1468-81. PMID: 16313630.
      View in: PubMed
    41. Takamatsu D, Bensing BA, Cheng H, Jarvis GA, Siboo IR, López JA, Griffiss JM, Sullam P. Binding of the Streptococcus gordonii surface glycoproteins GspB and Hsa to specific carbohydrate structures on platelet membrane glycoprotein Ibalpha. Mol Microbiol. 2005 Oct; 58(2):380-92. PMID: 16194227.
      View in: PubMed
    42. Takamatsu D, Bensing BA, Sullam P. Two additional components of the accessory sec system mediating export of the Streptococcus gordonii platelet-binding protein GspB. J Bacteriol. 2005 Jun; 187(11):3878-83. PMID: 15901716; PMCID: PMC1112061.
    43. Siboo IR, Chambers HF, Sullam P. Role of SraP, a Serine-Rich Surface Protein of Staphylococcus aureus, in binding to human platelets. Infect Immun. 2005 Apr; 73(4):2273-80. PMID: 15784571; PMCID: PMC1087419.
    44. Takamatsu D, Bensing BA, Sullam P. Four proteins encoded in the gspB-secY2A2 operon of Streptococcus gordonii mediate the intracellular glycosylation of the platelet-binding protein GspB. J Bacteriol. 2004 Nov; 186(21):7100-11. PMID: 15489421; PMCID: PMC523221.
    45. Bensing BA, López JA, Sullam P. The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibalpha. Infect Immun. 2004 Nov; 72(11):6528-37. PMID: 15501784; PMCID: PMC523053.
    46. Takamatsu D, Bensing BA, Sullam P. Genes in the accessory sec locus of Streptococcus gordonii have three functionally distinct effects on the expression of the platelet-binding protein GspB. Mol Microbiol. 2004 Apr; 52(1):189-203. PMID: 15049820.
      View in: PubMed
    47. Bensing BA, Gibson BW, Sullam P. The Streptococcus gordonii platelet binding protein GspB undergoes glycosylation independently of export. J Bacteriol. 2004 Feb; 186(3):638-45. PMID: 14729688; PMCID: PMC321503.
    48. Siboo IR, Bensing BA, Sullam P. Genomic organization and molecular characterization of SM1, a temperate bacteriophage of Streptococcus mitis. J Bacteriol. 2003 Dec; 185(23):6968-75. PMID: 14617660; PMCID: PMC262713.
    49. Daws MR, Sullam P, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. J Immunol. 2003 Jul 15; 171(2):594-9. PMID: 12847223.
      View in: PubMed
    50. Bensing BA, Sullam P. An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets. Mol Microbiol. 2002 May; 44(4):1081-94. PMID: 12010500.
      View in: PubMed
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