Gary Jarvis, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 26303
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Interaction of LOS and Innate Immunity in Neisseria Infection
    NIH I01BX000727Apr 1, 2011 - Dec 31, 2020
    Role: Principal Investigator
    Bacterial STI and Innate Immunity in HIV Susceptibility
    NIH R01AI063927Jul 1, 2005 - Mar 31, 2012
    Role: Principal Investigator
    IMMUNOLOGY OF BACTERIAL PNEUMONIA IN HTLV-II INFECTION
    NIH R01AI044103Mar 1, 2000 - Feb 28, 2004
    Role: Principal Investigator
    MECHANISM OF IGA1 INITIATED BACTERIAL LYSIS
    NIH R01AI032944Apr 1, 1995 - Mar 31, 1999
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS. J Lipid Res. 2020 11; 61(11):1437-1449. John CM, Phillips NJ, Jarvis GA. PMID: 32839198.
      View in: PubMed   Mentions:    Fields:    
    2. Cationic cell-penetrating peptide is bactericidal against Neisseria gonorrhoeae. J Antimicrob Chemother. 2019 11 01; 74(11):3245-3251. John CM, Li M, Feng D, Jarvis GA. PMID: 31424547.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors. J Antimicrob Chemother. 2018 08 01; 73(8):2064-2071. John CM, Feng D, Jarvis GA. PMID: 29726994.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence. J Lipid Res. 2018 10; 59(10):1893-1905. Brunner K, John CM, Phillips NJ, Alber DG, Gemmell MR, Hansen R, Nielsen HL, Hold GL, Bajaj-Elliott M, Jarvis GA. PMID: 30049709.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections. Pathog Dis. 2017 Apr 01; 75(3). John CM, Phillips NJ, Stein DC, Jarvis GA. PMID: 28423169.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2218-2223. Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A. PMID: 28193899.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    7. Analysis of Bacterial Lipooligosaccharides by MALDI-TOF MS with Traveling Wave Ion Mobility. J Am Soc Mass Spectrom. 2016 07; 27(7):1263-76. Phillips NJ, John CM, Jarvis GA. PMID: 27056565.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    8. Arginine- and Polyamine-Induced Lactic Acid Resistance in Neisseria gonorrhoeae. PLoS One. 2016; 11(1):e0147637. Gong Z, Tang MM, Wu X, Phillips N, Galkowski D, Jarvis GA, Fan H. PMID: 26808268.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    9. Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage. J Biol Chem. 2016 Feb 12; 291(7):3224-38. John CM, Phillips NJ, Din R, Liu M, Rosenqvist E, Høiby EA, Stein DC, Jarvis GA. PMID: 26655715.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a. J Immunol. 2014 Feb 15; 192(4):1768-77. Liu M, John CM, Jarvis GA. PMID: 24442429.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    11. Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation, and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation. J Biol Chem. 2013 Jul 05; 288(27):19661-72. Stephenson HN, John CM, Naz N, Gundogdu O, Dorrell N, Wren BW, Jarvis GA, Bajaj-Elliott M. PMID: 23629657.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    12. Post-injury conditioning with lipopolysaccharide or lipooligosaccharide reduces inflammation in the brain. J Neuroimmunol. 2013 Mar 15; 256(1-2):28-37. Bingham D, John CM, Levin J, Panter SS, Jarvis GA. PMID: 23333234.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect Immun. 2012 Nov; 80(11):4014-26. John CM, Liu M, Phillips NJ, Yang Z, Funk CR, Zimmerman LI, Griffiss JM, Stein DC, Jarvis GA. PMID: 22949553.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    14. The association between body mass index and severe biliary infections: a multivariate analysis. Am J Surg. 2012 Nov; 204(5):574-9. Stewart L, Griffiss JM, Jarvis GA, Way LW. PMID: 22892201.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Secretory leukocyte protease inhibitor binds to Neisseria gonorrhoeae outer membrane opacity protein and is bactericidal. Am J Reprod Immunol. 2012 Aug; 68(2):116-27. Cooper MD, Roberts MH, Barauskas OL, Jarvis GA. PMID: 22537232.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects. Curr HIV Res. 2012 Apr; 10(3):211-7. Jarvis GA, Chang TL. PMID: 22384840.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    17. Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure. J Biol Chem. 2011 Dec 23; 286(51):43622-43633. Cheng H, Yang Z, Estabrook MM, John CM, Jarvis GA, McLaughlin S, Griffiss JM. PMID: 22027827.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures. Brain Res Bull. 2011 Jul 15; 85(6):403-9. Bingham D, John CM, Panter SS, Jarvis GA. PMID: 21571046.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways. J Immunol. 2010 Dec 01; 185(11):6974-84. Liu M, John CM, Jarvis GA. PMID: 21037101.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    20. Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation. J Immunol. 2010 Mar 15; 184(6):2814-24. Ding J, Rapista A, Teleshova N, Mosoyan G, Jarvis GA, Klotman ME, Chang TL. PMID: 20147631.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    21. Natural phosphoryl and acyl variants of lipid A from Neisseria meningitidis strain 89I differentially induce tumor necrosis factor-alpha in human monocytes. J Biol Chem. 2009 Aug 07; 284(32):21515-25. John CM, Liu M, Jarvis GA. PMID: 19531474.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    22. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J Immunol. 2009 May 15; 182(10):6460-9. Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP. PMID: 19414800.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    23. Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction. J Lipid Res. 2009 Mar; 50(3):424-438. John CM, Liu M, Jarvis GA. PMID: 18832773.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    24. Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. J Immunol. 2008 May 01; 180(9):6176-85. Klotman ME, Rapista A, Teleshova N, Micsenyi A, Jarvis GA, Lu W, Porter E, Chang TL. PMID: 18424739.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    25. Elderly patients have more severe biliary infections: influence of complement-killing and induction of TNFalpha production. Surgery. 2008 Jan; 143(1):103-12. Stewart L, Grifiss JM, Jarvis GA, Way LW. PMID: 18154938.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Bacteria entombed in the center of cholesterol gallstones induce fewer infectious manifestations than bacteria in the matrix of pigment stones. J Gastrointest Surg. 2007 Oct; 11(10):1298-308. Stewart L, Griffiss JM, Jarvis GA, Way LW. PMID: 17653596.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Gallstones containing bacteria are biofilms: bacterial slime production and ability to form pigment solids determines infection severity and bacteremia. J Gastrointest Surg. 2007 Aug; 11(8):977-83; discussion 983-4. Stewart L, Griffiss JM, Jarvis GA, Way LW. PMID: 17546479.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    28. Affinity-purified human immunoglobulin G that binds a lacto-N-neotetraose-dependent lipooligosaccharide structure is bactericidal for serogroup B Neisseria meningitidis. Infect Immun. 2007 Feb; 75(2):1025-33. Estabrook MM, Jarvis GA, McLeod Griffiss J. PMID: 17101655.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    29. Biliary bacterial factors determine the path of gallstone formation. Am J Surg. 2006 Nov; 192(5):598-603. Stewart L, Grifiss JM, Jarvis GA, Way LW. PMID: 17071191.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    30. Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity. J Infect Dis. 2006 Sep 15; 194(6):751-9. Liu X, Mosoian A, Li-Yun Chang T, Zerhouni-Layachi B, Snyder A, Jarvis GA, Klotman ME. PMID: 16941340.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    31. Binding of the Streptococcus gordonii surface glycoproteins GspB and Hsa to specific carbohydrate structures on platelet membrane glycoprotein Ibalpha. Mol Microbiol. 2005 Oct; 58(2):380-92. Takamatsu D, Bensing BA, Cheng H, Jarvis GA, Siboo IR, López JA, Griffiss JM, Sullam PM. PMID: 16194227.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    32. Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action. Antimicrob Agents Chemother. 2005 Sep; 49(9):3607-15. Scordi-Bello IA, Mosoian A, He C, Chen Y, Cheng Y, Jarvis GA, Keller MJ, Hogarty K, Waller DP, Profy AT, Herold BC, Klotman ME. PMID: 16127029.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    33. Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines. J Infect Dis. 2005 Apr 15; 191(8):1239-44. Jarvis GA, Janoff EN, Cheng H, Devita D, Fasching C, McCulloch CE, Murphy EL. PMID: 15776369.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    34. Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread. Antimicrob Agents Chemother. 2004 Jun; 48(6):2025-36. Cheshenko N, Keller MJ, MasCasullo V, Jarvis GA, Cheng H, John M, Li JH, Hogarty K, Anderson RA, Waller DP, Zaneveld LJ, Profy AT, Klotman ME, Herold BC. PMID: 15155195.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    35. Mannose-binding lectin binds to two major outer membrane proteins, opacity protein and porin, of Neisseria meningitidis. J Immunol. 2004 Mar 15; 172(6):3784-92. Estabrook MM, Jack DL, Klein NJ, Jarvis GA. PMID: 15004183.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    36. Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains. Infect Immun. 2003 Jul; 71(7):3901-8. Pridmore AC, Jarvis GA, John CM, Jack DL, Dower SK, Read RC. PMID: 12819075.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    37. Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin Cancer Res. 2003 Jun; 9(6):2374-83. John CM, Leffler H, Kahl-Knutsson B, Svensson I, Jarvis GA. PMID: 12796408.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    38. Cholangitis: bacterial virulence factors that facilitate cholangiovenous reflux and tumor necrosis factor-alpha production. J Gastrointest Surg. 2003 Feb; 7(2):191-8; discussion 198-9. Stewart L, Oesterle AL, Grifiss JM, Jarvis GA, Way LW. PMID: 12600443.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol. 2002 Oct; 4(10):649-62. John CM, Jarvis GA, Swanson KV, Leffler H, Cooper MD, Huflejt ME, Griffiss JM. PMID: 12366402.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    40. Gram-negative bacteria killed by complement are associated with more severe biliary infections and produce more tumor necrosis factor-alpha in sera. Surgery. 2002 Aug; 132(2):408-14. Stewart L, Oesterle AL, Griffiss JM, Jarvis GA, Aagaard B, Way LW. PMID: 12219042.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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