Gary Jarvis, PhD

SchoolUCSF School of Medicine
DepartmentLaboratory Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 26303
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    Interaction of LOS and Innate Immunity in Neisseria Infection
    VA I01BX000727Apr 1, 2011 - Jun 30, 2020
    Role: Principal Investigator
    Bacterial STI and Innate Immunity in HIV Susceptibility
    NIH/NIAID R01AI063927Jul 1, 2005 - Mar 31, 2012
    Role: Principal Investigator
    NIH/NIAID R01AI044103Mar 1, 2000 - Feb 28, 2004
    Role: Principal Investigator
    NIH/NIAID R01AI032944Apr 1, 1995 - Mar 31, 1999
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. John CM, Phillips NJ, Stein DC, Jarvis G. Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections. Pathog Dis. 2017 Apr 01; 75(3). PMID: 28423169.
      View in: PubMed
    2. Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis G, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A. Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding. Proc Natl Acad Sci U S A. 2017 Feb 28; 114(9):2218-2223. PMID: 28193899.
      View in: PubMed
    3. Phillips NJ, John CM, Jarvis G. Analysis of Bacterial Lipooligosaccharides by MALDI-TOF MS with Traveling Wave Ion Mobility. J Am Soc Mass Spectrom. 2016 Jul; 27(7):1263-76. PMID: 27056565.
      View in: PubMed
    4. Gong Z, Tang MM, Wu X, Phillips N, Galkowski D, Jarvis G, Fan H. Arginine- and Polyamine-Induced Lactic Acid Resistance in Neisseria gonorrhoeae. PLoS One. 2016; 11(1):e0147637. PMID: 26808268; PMCID: PMC4726613.
    5. John CM, Phillips NJ, Din R, Liu M, Rosenqvist E, Høiby EA, Stein DC, Jarvis G. Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage. J Biol Chem. 2016 Feb 12; 291(7):3224-38. PMID: 26655715; PMCID: PMC4751370 [Available on 02/12/17].
    6. Liu M, John CM, Jarvis G. Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a. J Immunol. 2014 Feb 15; 192(4):1768-77. PMID: 24442429.
      View in: PubMed
    7. Stephenson HN, John CM, Naz N, Gundogdu O, Dorrell N, Wren BW, Jarvis G, Bajaj-Elliott M. Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation, and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation. J Biol Chem. 2013 Jul 05; 288(27):19661-72. PMID: 23629657; PMCID: PMC3707672.
    8. Bingham D, John CM, Levin J, Panter SS, Jarvis G. Post-injury conditioning with lipopolysaccharide or lipooligosaccharide reduces inflammation in the brain. J Neuroimmunol. 2013 Mar 15; 256(1-2):28-37. PMID: 23333234.
      View in: PubMed
    9. John CM, Liu M, Phillips NJ, Yang Z, Funk CR, Zimmerman LI, Griffiss JM, Stein DC, Jarvis G. Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect Immun. 2012 Nov; 80(11):4014-26. PMID: 22949553; PMCID: PMC3486066.
    10. Stewart L, Griffiss JM, Jarvis G, Way LW. The association between body mass index and severe biliary infections: a multivariate analysis. Am J Surg. 2012 Nov; 204(5):574-9. PMID: 22892201.
      View in: PubMed
    11. Cooper MD, Roberts MH, Barauskas OL, Jarvis G. Secretory leukocyte protease inhibitor binds to Neisseria gonorrhoeae outer membrane opacity protein and is bactericidal. Am J Reprod Immunol. 2012 Aug; 68(2):116-27. PMID: 22537232; PMCID: PMC3395761.
    12. Jarvis G, Chang TL. Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects. Curr HIV Res. 2012 Apr; 10(3):211-7. PMID: 22384840; PMCID: PMC4149178.
    13. Liu Y, Islam EA, Jarvis G, Gray-Owen SD, Russell MW. Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-ß-dependent mechanisms. Mucosal Immunol. 2012 May; 5(3):320-31. PMID: 22354319; PMCID: PMC3328619.
    14. Cheng H, Yang Z, Estabrook MM, John CM, Jarvis G, McLaughlin S, Griffiss JM. Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure. J Biol Chem. 2011 Dec 23; 286(51):43622-33. PMID: 22027827; PMCID: PMC3243514.
    15. Bingham D, John CM, Panter SS, Jarvis G. Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures. Brain Res Bull. 2011 Jul 15; 85(6):403-9. PMID: 21571046.
      View in: PubMed
    16. Liu M, John CM, Jarvis G. Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways. J Immunol. 2010 Dec 01; 185(11):6974-84. PMID: 21037101; PMCID: PMC3059745.
    17. Ding J, Rapista A, Teleshova N, Mosoyan G, Jarvis G, Klotman ME, Chang TL. Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation. J Immunol. 2010 Mar 15; 184(6):2814-24. PMID: 20147631; PMCID: PMC3739425.
    18. John CM, Liu M, Jarvis G. Natural phosphoryl and acyl variants of lipid A from Neisseria meningitidis strain 89I differentially induce tumor necrosis factor-alpha in human monocytes. J Biol Chem. 2009 Aug 07; 284(32):21515-25. PMID: 19531474; PMCID: PMC2755876.
    19. Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis G, Sparling PF, Ting JP. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J Immunol. 2009 May 15; 182(10):6460-9. PMID: 19414800; PMCID: PMC2722440.
    20. John CM, Liu M, Jarvis G. Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction. J Lipid Res. 2009 Mar; 50(3):424-38. PMID: 18832773; PMCID: PMC2638105.
    21. Klotman ME, Rapista A, Teleshova N, Micsenyi A, Jarvis G, Lu W, Porter E, Chang TL. Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. J Immunol. 2008 May 01; 180(9):6176-85. PMID: 18424739; PMCID: PMC3042429.
    22. Quan DN, Cooper MD, Potter JL, Roberts MH, Cheng H, Jarvis G. TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells. Mucosal Immunol. 2008 May; 1(3):229-38. PMID: 19079182; PMCID: PMC2614303.
    23. Stewart L, Grifiss JM, Jarvis G, Way LW. Elderly patients have more severe biliary infections: influence of complement-killing and induction of TNFalpha production. Surgery. 2008 Jan; 143(1):103-12. PMID: 18154938.
      View in: PubMed
    24. Stewart L, Griffiss JM, Jarvis G, Way LW. Bacteria entombed in the center of cholesterol gallstones induce fewer infectious manifestations than bacteria in the matrix of pigment stones. J Gastrointest Surg. 2007 Oct; 11(10):1298-308. PMID: 17653596.
      View in: PubMed
    25. Stewart L, Griffiss JM, Jarvis G, Way LW. Gallstones containing bacteria are biofilms: bacterial slime production and ability to form pigment solids determines infection severity and bacteremia. J Gastrointest Surg. 2007 Aug; 11(8):977-83; discussion 983-4. PMID: 17546479.
      View in: PubMed
    26. Estabrook MM, Jarvis G, McLeod Griffiss J. Affinity-purified human immunoglobulin G that binds a lacto-N-neotetraose-dependent lipooligosaccharide structure is bactericidal for serogroup B Neisseria meningitidis. Infect Immun. 2007 Feb; 75(2):1025-33. PMID: 17101655; PMCID: PMC1828497.
    27. Stewart L, Grifiss JM, Jarvis G, Way LW. Biliary bacterial factors determine the path of gallstone formation. Am J Surg. 2006 Nov; 192(5):598-603. PMID: 17071191.
      View in: PubMed
    28. Liu X, Mosoian A, Li-Yun Chang T, Zerhouni-Layachi B, Snyder A, Jarvis G, Klotman ME. Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity. J Infect Dis. 2006 Sep 15; 194(6):751-9. PMID: 16941340.
      View in: PubMed
    29. Takamatsu D, Bensing BA, Cheng H, Jarvis G, Siboo IR, López JA, Griffiss JM, Sullam PM. Binding of the Streptococcus gordonii surface glycoproteins GspB and Hsa to specific carbohydrate structures on platelet membrane glycoprotein Ibalpha. Mol Microbiol. 2005 Oct; 58(2):380-92. PMID: 16194227.
      View in: PubMed
    30. Scordi-Bello IA, Mosoian A, He C, Chen Y, Cheng Y, Jarvis G, Keller MJ, Hogarty K, Waller DP, Profy AT, Herold BC, Klotman ME. Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action. Antimicrob Agents Chemother. 2005 Sep; 49(9):3607-15. PMID: 16127029; PMCID: PMC1195443.
    31. Jarvis G, Janoff EN, Cheng H, Devita D, Fasching C, McCulloch CE, Murphy EL. Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines. J Infect Dis. 2005 Apr 15; 191(8):1239-44. PMID: 15776369.
      View in: PubMed
    32. Cheshenko N, Keller MJ, MasCasullo V, Jarvis G, Cheng H, John M, Li JH, Hogarty K, Anderson RA, Waller DP, Zaneveld LJ, Profy AT, Klotman ME, Herold BC. Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread. Antimicrob Agents Chemother. 2004 Jun; 48(6):2025-36. PMID: 15155195; PMCID: PMC415621.
    33. Estabrook MM, Jack DL, Klein NJ, Jarvis G. Mannose-binding lectin binds to two major outer membrane proteins, opacity protein and porin, of Neisseria meningitidis. J Immunol. 2004 Mar 15; 172(6):3784-92. PMID: 15004183.
      View in: PubMed
    34. Pridmore AC, Jarvis G, John CM, Jack DL, Dower SK, Read RC. Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains. Infect Immun. 2003 Jul; 71(7):3901-8. PMID: 12819075; PMCID: PMC161978.
    35. John CM, Leffler H, Kahl-Knutsson B, Svensson I, Jarvis G. Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin Cancer Res. 2003 Jun; 9(6):2374-83. PMID: 12796408.
      View in: PubMed
    36. Stewart L, Oesterle AL, Grifiss JM, Jarvis G, Way LW. Cholangitis: bacterial virulence factors that facilitate cholangiovenous reflux and tumor necrosis factor-alpha production. J Gastrointest Surg. 2003 Feb; 7(2):191-8; discussion 198-9. PMID: 12600443.
      View in: PubMed
    37. John CM, Jarvis G, Swanson KV, Leffler H, Cooper MD, Huflejt ME, Griffiss JM. Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol. 2002 Oct; 4(10):649-62. PMID: 12366402.
      View in: PubMed
    38. Stewart L, Oesterle AL, Griffiss JM, Jarvis G, Aagaard B, Way LW. Gram-negative bacteria killed by complement are associated with more severe biliary infections and produce more tumor necrosis factor-alpha in sera. Surgery. 2002 Aug; 132(2):408-14. PMID: 12219042.
      View in: PubMed
    39. Swanson KV, Jarvis G, Brooks GF, Barham BJ, Cooper MD, Griffiss JM. CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells. Cell Microbiol. 2001 Oct; 3(10):681-91. PMID: 11580753.
      View in: PubMed
    40. Jack DL, Jarvis G, Booth CL, Turner MW, Klein NJ. Mannose-binding lectin accelerates complement activation and increases serum killing of Neisseria meningitidis serogroup C. J Infect Dis. 2001 Oct 01; 184(7):836-45. PMID: 11509995.
      View in: PubMed
    41. Wang J, Jarvis G, Achtman M, Rosenqvist E, Michaelsen TE, Aase A, Griffiss JM. Functional activities and immunoglobulin variable regions of human and murine monoclonal antibodies specific for the P1.7 PorA protein loop of Neisseria meningitidis. Infect Immun. 2000 Apr; 68(4):1871-8. PMID: 10722576; PMCID: PMC97360.
    42. Jarvis G, Li J, Swanson KV. Invasion of human mucosal epithelial cells by Neisseria gonorrhoeae upregulates expression of intercellular adhesion molecule 1 (ICAM-1). Infect Immun. 1999 Mar; 67(3):1149-56. PMID: 10024555; PMCID: PMC96441.
    43. Rautemaa R, Jarvis G, Marnila P, Meri S. Acquired resistance of Escherichia coli to complement lysis by binding of glycophosphoinositol-anchored protectin (CD59). Infect Immun. 1998 May; 66(5):1928-33. PMID: 9573071; PMCID: PMC108145.
    44. Estabrook MM, Griffiss JM, Jarvis G. Sialylation of Neisseria meningitidis lipooligosaccharide inhibits serum bactericidal activity by masking lacto-N-neotetraose. Infect Immun. 1997 Nov; 65(11):4436-44. PMID: 9353017; PMCID: PMC175638.
    45. Jarvis G, Li J, Hakulinen J, Brady KA, Nordling S, Dahiya R, Meri S. Expression and function of the complement membrane attack complex inhibitor protectin (CD59) in human prostate cancer. Int J Cancer. 1997 Jun 11; 71(6):1049-55. PMID: 9185710.
      View in: PubMed
    46. Hamadeh RM, Jarvis G, Zhou P, Cotleur AC, Griffiss JM. Bacterial enzymes can add galactose alpha 1,3 to human erythrocytes and creates a senescence-associated epitope. Infect Immun. 1996 Feb; 64(2):528-34. PMID: 8550203; PMCID: PMC173797.
    47. Hamadeh RM, Estabrook MM, Zhou P, Jarvis G, Griffiss JM. Anti-Gal binds to pili of Neisseria meningitidis: the immunoglobulin A isotype blocks complement-mediated killing. Infect Immun. 1995 Dec; 63(12):4900-6. PMID: 7591153; PMCID: PMC173702.
    48. Jarvis G. Recognition and control of neisserial infection by antibody and complement. Trends Microbiol. 1995 May; 3(5):198-201. PMID: 7627458.
      View in: PubMed
    49. Jarvis G. Analysis of C3 deposition and degradation on Neisseria meningitidis and Neisseria gonorrhoeae. Infect Immun. 1994 May; 62(5):1755-60. PMID: 8168937; PMCID: PMC186402.
    50. Mandrell RE, Smith H, Jarvis G, Griffiss JM, Cole JA. Detection and some properties of the sialyltransferase implicated in the sialylation of lipopolysaccharide of Neisseria gonorrhoeae. Microb Pathog. 1993 Apr; 14(4):307-13. PMID: 8326854.
      View in: PubMed
    51. Hamadeh RM, Jarvis G, Galili U, Mandrell RE, Zhou P, Griffiss JM. Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces. J Clin Invest. 1992 Apr; 89(4):1223-35. PMID: 1556184; PMCID: PMC442982.
    52. Jarvis G, Griffiss JM. Human IgA1 blockade of IgG-initiated lysis of Neisseria meningitidis is a function of antigen-binding fragment binding to the polysaccharide capsule. J Immunol. 1991 Sep 15; 147(6):1962-7. PMID: 1909736.
      View in: PubMed
    53. Griffiss JM, Jarvis G, O'Brien JP, Eads MM, Schneider H. Lysis of Neisseria gonorrhoeae initiated by binding of normal human IgM to a hexosamine-containing lipooligosaccharide epitope(s) is augmented by strain-specific, properdin-binding-dependent alternative complement pathway activation. J Immunol. 1991 Jul 01; 147(1):298-305. PMID: 1711080.
      View in: PubMed
    54. Blumenfeld W, Mandrell RE, Jarvis G, Griffiss JM. Localization of host immunoglobulin G to the surface of Pneumocystis carinii. Infect Immun. 1990 Feb; 58(2):456-63. PMID: 2298486; PMCID: PMC258479.
    55. Jarvis G, Griffiss JM. Human IgA1 initiates complement-mediated killing of Neisseria meningitidis. J Immunol. 1989 Sep 01; 143(5):1703-9. PMID: 2474610.
      View in: PubMed
    56. Sullam PM, Jarvis G, Valone FH. Role of immunoglobulin G in platelet aggregation by viridans group streptococci. Infect Immun. 1988 Nov; 56(11):2907-11. PMID: 2971621; PMCID: PMC259669.
    57. Griffiss JM, Schneider H, Mandrell RE, Yamasaki R, Jarvis G, Kim JJ, Gibson BW, Hamadeh R, Apicella MA. Lipooligosaccharides: the principal glycolipids of the neisserial outer membrane. Rev Infect Dis. 1988 Jul-Aug; 10 Suppl 2:S287-95. PMID: 2460911.
      View in: PubMed
    58. Apicella MA, Shero M, Jarvis G, Griffiss JM, Mandrell RE, Schneider H. Phenotypic variation in epitope expression of the Neisseria gonorrhoeae lipooligosaccharide. Infect Immun. 1987 Aug; 55(8):1755-61. PMID: 2440807; PMCID: PMC260597.
    59. Griffiss JM, Jarvis G. Interaction of serum IgA with complement components: the molecular basis of IgA blockade. Adv Exp Med Biol. 1987; 216B:1303-9. PMID: 3425430.
      View in: PubMed
    60. Griffiss JM, Schneider H, Mandrell RE, Jarvis G, Kim JJ, Gibson B, Apicella MA. The immunochemistry of neisserial LOS. Antonie Van Leeuwenhoek. 1987; 53(6):501-7. PMID: 2453159.
      View in: PubMed
    61. Jarvis G, Vedros NA. Sialic acid of group B Neisseria meningitidis regulates alternative complement pathway activation. Infect Immun. 1987 Jan; 55(1):174-80. PMID: 3098684; PMCID: PMC260297.
    62. Schneider H, Griffiss JM, Mandrell RE, Jarvis G. Elaboration of a 3.6-kilodalton lipooligosaccharide, antibody against which is absent from human sera, is associated with serum resistance of Neisseria gonorrhoeae. Infect Immun. 1985 Dec; 50(3):672-7. PMID: 3934078; PMCID: PMC261131.
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