Bob Bhisitkul, MD, PhD

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address10 Koret Way, #54Ha
San Francisco CA 94117
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    1. Heterogeneity in disease activity, frequency of treatments, and visual outcomes among patients with retinal vein occlusion: relationship between injection need and vision with as-needed ranibizumab. Br J Ophthalmol. 2024 Aug 22; 108(9):1216-1225. Bhisitkul RB, Campochiaro PA, Blotner S, Quezada-Ruiz C, Liu M, Haskova Z. PMID: 38290802; PMCID: PMC11347224.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    2. Subretinal hyperreflective material in regions of atrophy and fibrosis in eyes with neovascular age-related macular degeneration. Can J Ophthalmol. 2025 Feb; 60(1):26-34. Lindenberg S, Nittala MG, Verma A, Fitzgerald MEC, Velaga SB, Bhisitkul RB, Sadda SR. PMID: 38815954.
      View in: PubMed   Mentions: 1     Fields:    
    3. Safety and tolerability of intravitreal umedaptanib pegol (anti-FGF2) for neovascular age-related macular degeneration (nAMD): a phase 1, open-label study. Eye (Lond). 2024 Apr; 38(6):1149-1154. Pereira DS, Akita K, Bhisitkul RB, Nishihata T, Ali Y, Nakamura E, Nakamura Y. PMID: 38040965; PMCID: PMC11009303.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    4. Clinical proof of concept for anti-FGF2 therapy in exudative age-related macular degeneration (nAMD): phase 2 trials in treatment-naïve and anti-VEGF pretreated patients. Eye (Lond). 2024 Apr; 38(6):1140-1148. Pereira DS, Maturi RK, Akita K, Mahesh V, Bhisitkul RB, Nishihata T, Sakota E, Ali Y, Nakamura E, Bezwada P, Nakamura Y. PMID: 38036609; PMCID: PMC11009322.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    5. Injectable Devices for Delivery of Liquid or Solid Protein Formulations. ACS Mater Au. 2023 May 10; 3(3):255-264. Bernards DA, Ma CJ, Zhang Y, Rodriguez TM, Dickson J, Kharbikar BN, Bhisitkul RB, Desai TA. PMID: 38089136; PMCID: PMC10176615.
      View in: PubMed   Mentions: 2  
    6. Macular Atrophy Incidence, Progression, and Visual Acuity Effects in 5-Year Treatment of Neovascular Age-Related Macular Degeneration. Ophthalmic Surg Lasers Imaging Retina. 2022 Oct; 53(10):546-552. Richardson QR, Zhang Y, Deiner MS, Wang ST, Bhisitkul JM, Arnold BF, Bhisitkul RB. PMID: 36239676.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. BILATERAL ENTEROCOCCUS FAECALIS ENDOPHTHALMITIS WITH MULTIPLE RECURRENCES. Retin Cases Brief Rep. 2021 Jan 01; 15(1):38-42. Aderman CM, Chao DL, Obeid A, Schwartz DM, Bhisitkul RB, Chiu CS. PMID: 29489562.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    8. Rhegmatogenous retinal detachment masquerading as exudative panuveitis with intense anterior chamber inflammatory reaction. Am J Ophthalmol Case Rep. 2020 Jun; 18:100618. Joye AS, Bhisitkul RB, Pereira DDS, Gonzales JA. PMID: 32154433; PMCID: PMC7056619.
      View in: PubMed   Mentions: 1  
    9. Glass intraocular foreign body removal with a nitinol stone basket. Am J Ophthalmol Case Rep. 2019 Dec; 16:100541. Francis AW, Wu F, Zhu I, de Souza Pereira D, Bhisitkul RB. PMID: 31517137; PMCID: PMC6732721.
      View in: PubMed   Mentions: 3  
    10. Anti-Angiogenic and Anti-Scarring Dual Action of an Anti-Fibroblast Growth Factor 2 Aptamer in Animal Models of Retinal Disease. Mol Ther Nucleic Acids. 2019 Sep 06; 17:819-828. Matsuda Y, Nonaka Y, Futakawa S, Imai H, Akita K, Nishihata T, Fujiwara M, Ali Y, Bhisitkul RB, Nakamura Y. PMID: 31454678; PMCID: PMC6716068.
      View in: PubMed   Mentions: 24  
    11. Co-Delivery of Timolol and Brimonidine with a Polymer Thin-Film Intraocular Device. J Ocul Pharmacol Ther. 2019 03; 35(2):124-131. Samy KE, Cao Y, Kim J, Konichi da Silva NR, Phone A, Bloomer MM, Bhisitkul RB, Desai TA. PMID: 30615539; PMCID: PMC6450452.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    12. Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery. Bioeng Transl Med. 2019 Jan; 4(1):152-163. Schlesinger EB, Bernards DA, Chen HH, Feindt J, Cao J, Dix D, Romano C, Bhisitkul RB, Desai TA. PMID: 30680326; PMCID: PMC6336666.
      View in: PubMed   Mentions: 8  
    13. Long-term intraocular pressure reduction with intracameral polycaprolactone glaucoma devices that deliver a novel anti-glaucoma agent. J Control Release. 2018 01 10; 269:45-51. Kim J, Kudisch M, da Silva NRK, Asada H, Aya-Shibuya E, Bloomer MM, Mudumba S, Bhisitkul RB, Desai TA. PMID: 29127001; PMCID: PMC5748363.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    14. Manual Removal of Intraocular Lens Silicone Oil Droplets and Dystrophic Calcifications Using a Nitinol Loop: A Case Series. Ophthalmic Surg Lasers Imaging Retina. 2017 05 01; 48(5):422-426. Moussa K, Leng T, Oatts JT, Bhisitkul RB, Hwang DG, Stewart JM. PMID: 28499054.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. In vivo and in vitro sustained release of ranibizumab from a nanoporous thin-film device. Drug Deliv Transl Res. 2016 12; 6(6):771-780. Lance KD, Bernards DA, Ciaccio NA, Good SD, Mendes TS, Kudisch M, Chan E, Ishikiriyama M, Bhisitkul RB, Desai TA. PMID: 27178165; PMCID: PMC5097678.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    16. Biocompatibility and Pharmacokinetic Analysis of an Intracameral Polycaprolactone Drug Delivery Implant for Glaucoma. Invest Ophthalmol Vis Sci. 2016 08 01; 57(10):4341-6. Kim J, Kudisch M, Mudumba S, Asada H, Aya-Shibuya E, Bhisitkul RB, Desai TA. PMID: 27556217; PMCID: PMC5015984.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    17. Fellow Eye Comparisons for 7-Year Outcomes in Ranibizumab-Treated AMD Subjects from ANCHOR, MARINA, and HORIZON (SEVEN-UP Study). Ophthalmology. 2016 06; 123(6):1269-77. Bhisitkul RB, Desai SJ, Boyer DS, Sadda SR, Zhang K. PMID: 26996339.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    18. Predictors of Macular Atrophy Detected by Fundus Autofluorescence in Patients With Neovascular Age-Related Macular Degeneration After Long-Term Ranibizumab Treatment. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar; 47(3):224-31. Kuehlewein L, Dustin L, Sagong M, Hariri A, Mendes TS, Rofagha S, Bhisitkul RB, Sadda SR. PMID: 26985795.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. Reply. Am J Ophthalmol. 2016 Feb; 162:200-1. Bhisitkul RB, Mendes TS, Rofagha S, Enanoria W, Boyer DS, Sadda SR, Zhang K. PMID: 26621610.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. In Vitro and In Vivo Sustained Zero-Order Delivery of Rapamycin (Sirolimus) From a Biodegradable Intraocular Device. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7331-7. Lance KD, Good SD, Mendes TS, Ishikiriyama M, Chew P, Estes LS, Yamada K, Mudumba S, Bhisitkul RB, Desai TA. PMID: 26559479; PMCID: PMC4642602.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    21. Correlation of Serial Scleral and Corneal Pneumatonometry. Ophthalmology. 2015 Sep; 122(9):1771-6. Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan JL, Han Y. PMID: 26165473; PMCID: PMC4549181.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. Macular atrophy progression and 7-year vision outcomes in subjects from the ANCHOR, MARINA, and HORIZON studies: the SEVEN-UP study. Am J Ophthalmol. 2015 May; 159(5):915-24.e2. Bhisitkul RB, Mendes TS, Rofagha S, Enanoria W, Boyer DS, Sadda SR, Zhang K. PMID: 25640411.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCTClinical Trials
    23. Same-Day Versus Next-Day Repair of Fovea-Threatening Primary Rhegmatogenous Retinal Detachments. Semin Ophthalmol. 2016; 31(3):219-25. Gorovoy IR, Porco TC, Bhisitkul RB, de Juan E, Schwartz DM, Stewart JM. PMID: 25081305.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Age-related macular degeneration and protective effect of HMG Co-A reductase inhibitors (statins): results from the National Health and Nutrition Examination Survey 2005-2008. Eye (Lond). 2014 Apr; 28(4):472-80. Barbosa DT, Mendes TS, Cíntron-Colon HR, Wang SY, Bhisitkul RB, Singh K, Lin SC. PMID: 24503725; PMCID: PMC3983650.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    25. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013 Nov; 120(11):2292-9. Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group. PMID: 23642856.
      View in: PubMed   Mentions: 426     Fields:    Translation:HumansCTClinical Trials
    26. Predictive value in retinal vein occlusions of early versus late or incomplete ranibizumab response defined by optical coherence tomography. Ophthalmology. 2013 May; 120(5):1057-63. Bhisitkul RB, Campochiaro PA, Shapiro H, Rubio RG. PMID: 23415775.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCTClinical Trials
    27. Ocular biocompatibility and structural integrity of micro- and nanostructured poly(caprolactone) films. J Ocul Pharmacol Ther. 2013 Mar; 29(2):249-57. Bernards DA, Bhisitkul RB, Wynn P, Steedman MR, Lee OT, Wong F, Thoongsuwan S, Desai TA. PMID: 23391326; PMCID: PMC3601720.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    28. Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion. Ophthalmology. 2013 Apr; 120(4):795-802. Campochiaro PA, Bhisitkul RB, Shapiro H, Rubio RG. PMID: 23260261.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCTClinical Trials
    29. Risk factors for retinal detachment following cataract surgery. Curr Opin Ophthalmol. 2012 Jan; 23(1):7-11. Haug SJ, Bhisitkul RB. PMID: 22081033.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    30. Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study. Ophthalmology. 2011 Aug; 118(8):1594-602. Brown DM, Campochiaro PA, Bhisitkul RB, Ho AC, Gray S, Saroj N, Adamis AP, Rubio RG, Murahashi WY. PMID: 21684606.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansCTClinical Trials
    31. Management of retained lens fragments in complicated cataract surgery. Curr Opin Ophthalmol. 2011 Mar; 22(2):137-40. Rofagha S, Bhisitkul RB. PMID: 21191293.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    32. Bleb-associated infections after intravitreal injection. Retin Cases Brief Rep. 2011; 5(4):315-7. Thoongsuwan S, Dawn Lam HH, Bhisitkul RB. PMID: 25390423.
      View in: PubMed   Mentions: 1     Fields:    
    33. Safety monitoring with ocular anti-vascular endothelial growth factor therapies. Br J Ophthalmol. 2008 Dec; 92(12):1573-4. Fung AE, Bhisitkul RB. PMID: 19029158.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Spontaneous resolution of a traumatic cataract caused by an intralenticular foreign body. J Cataract Refract Surg. 2008 Jun; 34(6):1033-5. Rofagha S, Day S, Winn BJ, Ou JI, Bhisitkul RB, Chiu CS. PMID: 18499015.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):4071-7. Bhisitkul RB, Winn BJ, Lee OT, Wong J, Pereira Dde S, Porco TC, He X, Hahn P, Dunaief JL. PMID: 18421081.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    36. Iron homeostasis and toxicity in retinal degeneration. Prog Retin Eye Res. 2007 Nov; 26(6):649-73. He X, Hahn P, Iacovelli J, Wong R, King C, Bhisitkul R, Massaro-Giordano M, Dunaief JL. PMID: 17921041; PMCID: PMC2093950.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    37. Subgroup analysis of the MARINA study of ranibizumab in neovascular age-related macular degeneration. Ophthalmology. 2007 Feb; 114(2):246-52. Boyer DS, Antoszyk AN, Awh CC, Bhisitkul RB, Shapiro H, Acharya NR, MARINA Study Group. PMID: 17270674.
      View in: PubMed   Mentions: 140     Fields:    Translation:Humans
    38. Vascular endothelial growth factor biology: clinical implications for ocular treatments. Br J Ophthalmol. 2006 Dec; 90(12):1542-7. Bhisitkul RB. PMID: 17114590; PMCID: PMC1857529.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    39. Expanding treatment options in age-related macular degeneration. Int Ophthalmol Clin. 2006; 46(4):123-9. Bhisitkul RB, Rutar T. PMID: 17060798.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    40. Development of Microelectromechanical Systems (MEMS) forceps for intraocular surgery. Br J Ophthalmol. 2005 Dec; 89(12):1586-8. Bhisitkul RB, Keller CG. PMID: 16299136; PMCID: PMC1772987.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    41. Registration of clinical trials. Arch Ophthalmol. 2005 Sep; 123(9):1263-4. Levin LA, Gottlieb JL, Beck RW, Albert DM, Liesegang TJ, Hoyt CS, Dick A, Bhisitkul R, Schachat AP. PMID: 16157810.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. "Heavy oil" for intraocular tamponade in retinal detachment surgery. Br J Ophthalmol. 2005 Jun; 89(6):649-50. Bhisitkul RB, Gonzalez VH. PMID: 15923493; PMCID: PMC1772660.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    43. An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization. Arch Ophthalmol. 2005 Feb; 123(2):214-9. Bhisitkul RB, Robinson GS, Moulton RS, Claffey KP, Gragoudas ES, Miller JW. PMID: 15710818.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    44. Found in translation. Br J Ophthalmol. 2004 Dec; 88(12):1485. Kwok AH, Pereira DS, Bhisitkul RB. PMID: 15548794; PMCID: PMC1772425.
      View in: PubMed   Mentions: 1     Fields:    
    45. BDNF reduces the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4190-6. Paskowitz DM, Nune G, Yasumura D, Yang H, Bhisitkul RB, Sharma S, Matthes MT, Zarbin MA, Lavail MM, Duncan JL. PMID: 15505074.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    46. Distinguishing features of nontraumatic and traumatic retinal dialyses. Retina. 2004 Oct; 24(5):669-75. Hollander DA, Irvine AR, Poothullil AM, Bhisitkul RB. PMID: 15492620.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    47. Bloom syndrome: multiple retinopathies in a chromosome breakage disorder. Br J Ophthalmol. 2004 Mar; 88(3):354-7. Bhisitkul RB, Rizen M. PMID: 14977768; PMCID: PMC1772056.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    48. Second generation vital stains in retinal surgery. Br J Ophthalmol. 2003 Jun; 87(6):664-5. Bhisitkul RB. PMID: 12770955; PMCID: PMC1771710.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. A small number of older type 2 diabetic patients end up visually impaired,. by C. Hansson-Lundblad, K. Holm, C. D. Agardh, and E. Agardh. Acta Ophthalmol Scan 80:310-5, 2002. Surv Ophthalmol. 2003 Mar-Apr; 48(2):238. Bhisitkul R. PMID: 12686312.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    50. Systemic non-Hodgkin's lymphoma with optic nerve infiltration in a patient with AIDS. Retina. 2002 Feb; 22(1):75-9. Lee LC, Howes EL, Bhisitkul RB. PMID: 11884882.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    51. Anticipation for enzymatic vitreolysis. Br J Ophthalmol. 2001 Jan; 85(1):1-2. Bhisitkul RB. PMID: 11133700; PMCID: PMC1723669.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    52. Optic disk edema associated with peripapillary serous retinal detachment: an early sign of systemic Bartonella henselae infection. Am J Ophthalmol. 2000 Sep; 130(3):327-34. Wade NK, Levi L, Jones MR, Bhisitkul R, Fine L, Cunningham ET. PMID: 11020412.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    53. Bacterial subretinal abscess: a case report and review of the literature. Am J Ophthalmol. 2000 Jun; 129(6):778-85. Harris EW, D'Amico DJ, Bhisitkul R, Priebe GP, Petersen R. PMID: 10926988.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    54. Spontaneous central retinal artery occlusion in hemoglobin sickle cell disease. Am J Ophthalmol. 2000 May; 129(5):680-1. Fine LC, Petrovic' V, Irvine AR, Bhisitkul RB. PMID: 10844071.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    55. Soccer ball-related retinal injuries: a report of 13 cases. Retina. 2000; 20(6):604-9. Horn EP, McDonald HR, Johnson RN, Ai E, Williams GA, Lewis JM, Rubsamen PE, Sternberg P, Bhisitkul RB, Mieler WF. PMID: 11131412.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    56. Lasers and diabetic retinopathy: the art of gentle destruction. Diabetes Technol Ther. 1999; 1(2):177-87. Petrovic V, Bhisitkul RB. PMID: 11475290.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    57. Emerging chemotherapeutic strategies in the management of intraocular retinoblastoma. Int Ophthalmol Clin. 1997; 37(4):201-14. Bhisitkul RB, Mukai S. PMID: 9429942.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    58. Diagnosis and ophthalmological features of Behçet's disease. Int Ophthalmol Clin. 1996; 36(1):127-34. Bhisitkul RB, Foster CS. PMID: 8778058.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    59. A voltage- and time-dependent rectification in rat dorsal spinal root axons. J Neurophysiol. 1991 Sep; 66(3):719-28. Birch BD, Kocsis JD, Di Gregorio F, Bhisitkul RB, Waxman SG. PMID: 1661325.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    60. Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons. Exp Neurol. 1990 Sep; 109(3):273-8. Bhisitkul RB, Kocsis JD, Gordon TR, Waxman SG. PMID: 2170161.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    61. Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve. Exp Brain Res. 1987; 66(3):659-63. Bhisitkul RB, Villa JE, Kocsis JD. PMID: 3038587.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    62. Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in rat cerebellar cortex. Proc Natl Acad Sci U S A. 1984 Oct; 81(20):6531-4. Kocsis JD, Eng DL, Bhisitkul RB. PMID: 6093104; PMCID: PMC391958.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
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