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Yvonne Ou, MD

Title(s)Associate Professor, Ophthalmology
SchoolSchool of Medicine
Phone415-476-0779
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    Collapse Biography 
    Collapse Education and Training
    Harvard CollegeB.A.Biochemical Sciences
    Harvard Medical SchoolM.D.
    Brigham & Women's HospitalInternshipInternal Medicine
    Jules Stein Eye Institute/UCLAResidencyOphthalmology
    Duke UniversityClinical and Research FellowshipGlaucoma

    Collapse Overview 
    Collapse Overview
    Our laboratory studies the cellular and synaptic mechanisms of glaucomatous neurodegeneration. We are particularly interested in understanding the earliest steps of inner retina circuit disassembly in response to injury. Our research program combines imaging and analysis of specific cell and synaptic labels in the retina, rodent models of experimental glaucoma, novel genetic tools in which specific cell types are labeled, and the tools of molecular/cell biology and physiology to address a series of questions that, unanswered, have prevented progress in the field: 1) What are the early steps of compartmentalized neurodegeneration of the ganglion cell in glaucoma? 2) Are there specific ganglion cell types that are more susceptible to intraocular pressure (IOP) elevation? 3) Are there specific inner retinal circuits that are more susceptible to IOP elevation? As a clinician-scientist, I am motivated to advance our field not only by answering these fundamental questions, but also by translating the knowledge gained into improvements in diagnostic and treatment modalities in glaucoma. For example, a detailed understanding of the earliest structural and functional changes that occur in glaucoma will allow us to design treatments that can rescue RGCs, perhaps the most susceptible RGCs, before irreversible cell death occurs. Our long-term goal is to understand the mechanisms underlying ganglion cell degeneration and circuit remodeling in glaucoma in order to improve diagnosis and treatment.

    Collapse Research 
    Collapse Research Activities and Funding
    Neuronal plasticity in glaucoma
    NIH/NEI R01EY028148May 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Compartmentalized neurodegeneration of retinal ganglion cells in glaucoma
    NIH/NEI K08EY022676Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Perez CI, Han Y, Rose-Nussbaumer J, Ou Y, Hsia YC. Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation. Am J Ophthalmol Case Rep. 2019 Sep; 15:100469. PMID: 31193794.
      View in: PubMed
    2. Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA. Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit. Cell Rep. 2019 May 14; 27(7):2171-2183.e5. PMID: 31091454.
      View in: PubMed
    3. Ward ME, Gelfand JM, Lui LY, Ou Y, Green AJ, Stone K, Pedula KL, Cummings SR, Yaffe K. Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol. 2018 Apr; 83(4):730-738. PMID: 29518257.
      View in: PubMed
    4. Santina LD, Ou Y. Biolistic Labeling of Retinal Ganglion Cells. Methods Mol Biol. 2018; 1695:161-170. PMID: 29190026.
      View in: PubMed
    5. Zhang L, Li G, Shi M, Liu HH, Ge S, Ou Y, Flanagan JG, Chen L. Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3879-3886. PMID: 28763561.
      View in: PubMed
    6. Chang I, Caprioli J, Ou Y. Surgical Management of Pediatric Glaucoma. Dev Ophthalmol. 2017; 59:165-178. PMID: 28442696.
      View in: PubMed
    7. Mao M, Kiss M, Ou Y, Gould DB. Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse. Dis Model Mech. 2017 04 01; 10(4):475-485. PMID: 28237965.
      View in: PubMed
    8. Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L. Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension. J Neurosci. 2016 08 31; 36(35):9240-52. PMID: 27581463.
      View in: PubMed
    9. Della Santina L, Ou Y. Who's lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma. Exp Eye Res. 2017 05; 158:43-50. PMID: 27319294.
      View in: PubMed
    10. Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan JL, Han Y. Correlation of Serial Scleral and Corneal Pneumatonometry. Ophthalmology. 2015 Sep; 122(9):1771-6. PMID: 26165473; PMCID: PMC4549181.
    11. Green DI Ou Y.Expert Review of Ophthalmology. Towards the development of a human glaucoma disease-in-a-dish model using stem cells. 2015; 10(3):267-280.
    12. Schallhorn JM, Schallhorn SC, Ou Y. Factors that influence intraocular pressure changes after myopic and hyperopic LASIK and photorefractive keratectomy: a large population study. Ophthalmology. 2015 Mar; 122(3):471-9. PMID: 25444636.
      View in: PubMed
    13. Lin CC, Chen A, Jeng BH, Porco TC, Ou Y, Han Y. Scleral intraocular pressure measurement in cadaver eyes pre- and postkeratoprosthesis implantation. Invest Ophthalmol Vis Sci. 2014 Apr 09; 55(4):2244-50. PMID: 24557348.
      View in: PubMed
    14. Law SK, Tamboli DA, Ou Y, Giaconi JA, Caprioli J. Development of a resident training module for systematic optic disc evaluation in glaucoma. J Glaucoma. 2012 Dec; 21(9):601-7. PMID: 21602706.
      View in: PubMed
    15. Ou Y, Grossman DS, Lee PP, Sloan FA. Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis. Ophthalmic Epidemiol. 2012 Oct; 19(5):285-92. PMID: 22978529.
      View in: PubMed
    16. Ou Y, Caprioli J. Surgical management of pediatric glaucoma. Dev Ophthalmol. 2012; 50:157-72. PMID: 22517182.
      View in: PubMed
    17. Ou Y, Goldberg I, Migdal C, Lee PP. A critical appraisal and comparison of the quality and recommendations of glaucoma clinical practice guidelines. Ophthalmology. 2011 Jun; 118(6):1017-23. PMID: 21507487.
      View in: PubMed
    18. Ou Y, Yu F, Law SK, Coleman AL, Caprioli J. Outcomes of Ahmed glaucoma valve implantation in children with primary congenital glaucoma. Arch Ophthalmol. 2009 Nov; 127(11):1436-41. PMID: 19901208.
      View in: PubMed
    19. Wang GS, Hong CJ, Yen TY, Huang HY, Ou Y, Huang TN, Jung WG, Kuo TY, Sheng M, Wang TF, Hsueh YP. Transcriptional modification by a CASK-interacting nucleosome assembly protein. Neuron. 2004 Apr 08; 42(1):113-28. PMID: 15066269.
      View in: PubMed
    20. Wang TF, Ou Y, Guidotti G. The transmembrane domains of ectoapyrase (CD39) affect its enzymatic activity and quaternary structure. J Biol Chem. 1998 Sep 18; 273(38):24814-21. PMID: 9733785.
      View in: PubMed