Yvonne Ou, MD

Title(s)Associate Professor, Ophthalmology
SchoolSchool of Medicine
Address10 Koret Way
San Francisco CA 94117
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    Collapse Education and Training
    Harvard CollegeB.A.Biochemical Sciences
    Harvard Medical SchoolM.D.
    Brigham & Women's HospitalInternshipInternal Medicine
    Jules Stein Eye Institute/UCLAResidencyOphthalmology
    Duke UniversityClinical and Research FellowshipGlaucoma
    UCSF03/2021Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Our laboratory studies the cellular and synaptic mechanisms of glaucomatous neurodegeneration. We are particularly interested in understanding the earliest steps of inner retina circuit disassembly in response to injury. Our research program combines imaging and analysis of specific cell and synaptic labels in the retina, rodent models of experimental glaucoma, novel genetic tools in which specific cell types are labeled, and the tools of molecular/cell biology and physiology to address a series of questions that, unanswered, have prevented progress in the field: 1) What are the early steps of compartmentalized neurodegeneration of the ganglion cell in glaucoma? 2) Are there specific ganglion cell types that are more susceptible to intraocular pressure (IOP) elevation? 3) Are there specific inner retinal circuits that are more susceptible to IOP elevation? As a clinician-scientist, I am motivated to advance our field not only by answering these fundamental questions, but also by translating the knowledge gained into improvements in diagnostic and treatment modalities in glaucoma. For example, a detailed understanding of the earliest structural and functional changes that occur in glaucoma will allow us to design treatments that can rescue RGCs, perhaps the most susceptible RGCs, before irreversible cell death occurs. Our long-term goal is to understand the mechanisms underlying ganglion cell degeneration and circuit remodeling in glaucoma in order to improve diagnosis and treatment.

    Collapse Research 
    Collapse Research Activities and Funding
    UCSF-Proctor Clinician Vision Scholars K12 Program
    NIH K12EY031372May 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Neuronal plasticity in glaucoma
    NIH R01EY028148May 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Compartmentalized neurodegeneration of retinal ganglion cells in glaucoma
    NIH K08EY022676Sep 15, 2012 - Aug 31, 2018
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Clinical Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty at One Year in Open-Angle Glaucoma. Clin Ophthalmol. 2021; 15:243-251. Sun CQ, Chen TA, Deiner MS, Ou Y. PMID: 33519186.
      View in: PubMed   Mentions:
    2. Probing ON and OFF Retinal Pathways in Glaucoma Using Electroretinography. Transl Vis Sci Technol. 2020 10; 9(11):14. Kong AW, Della Santina L, Ou Y. PMID: 33117606.
      View in: PubMed   Mentions:
    3. Subconjunctival Injections of Mitomycin C Are Associated with a Lower Incidence of Hypertensive Phase in Eyes with Ahmed Glaucoma Valve. Ophthalmol Glaucoma. 2021 May-Jun; 4(3):322-329. Perez CI, Verdaguer S, Khaliliyeh D, Maul EA, Ou Y, Han Y. PMID: 33059114.
      View in: PubMed   Mentions:
    4. Implementing and Monitoring At-Home Virtual Reality Oculo-kinetic Perimetry During COVID-19. Ophthalmology. 2020 09; 127(9):1258. Deiner MS, Damato BE, Ou Y. PMID: 32535062.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    5. Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation. Am J Ophthalmol Case Rep. 2019 Sep; 15:100469. Perez CI, Han Y, Rose-Nussbaumer J, Ou Y, Hsia YC. PMID: 31193794.
      View in: PubMed   Mentions:
    6. Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit. Cell Rep. 2019 05 14; 27(7):2171-2183.e5. Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA. PMID: 31091454.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol. 2018 04; 83(4):730-738. Ward ME, Gelfand JM, Lui LY, Ou Y, Green AJ, Stone K, Pedula KL, Cummings SR, Yaffe K. PMID: 29518257.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    8. Biolistic Labeling of Retinal Ganglion Cells. Methods Mol Biol. 2018; 1695:161-170. Santina LD, Ou Y. PMID: 29190026.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3879-3886. Zhang L, Li G, Shi M, Liu HH, Ge S, Ou Y, Flanagan JG, Chen L. PMID: 28763561.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Surgical Management of Pediatric Glaucoma. Dev Ophthalmol. 2017; 59:165-178. Chang I, Caprioli J, Ou Y. PMID: 28442696.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse. Dis Model Mech. 2017 04 01; 10(4):475-485. Mao M, Kiss M, Ou Y, Gould DB. PMID: 28237965.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    12. Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension. J Neurosci. 2016 08 31; 36(35):9240-52. Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L. PMID: 27581463.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    13. Who's lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma. Exp Eye Res. 2017 05; 158:43-50. Della Santina L, Ou Y. PMID: 27319294.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. Correlation of Serial Scleral and Corneal Pneumatonometry. Ophthalmology. 2015 Sep; 122(9):1771-6. Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan JL, Han Y. PMID: 26165473.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Expert Review of Ophthalmology. Towards the development of a human glaucoma disease-in-a-dish model using stem cells. 2015; 10(3):267-280. Green DI Ou Y. . View Publication.
    16. Factors that influence intraocular pressure changes after myopic and hyperopic LASIK and photorefractive keratectomy: a large population study. Ophthalmology. 2015 Mar; 122(3):471-9. Schallhorn JM, Schallhorn SC, Ou Y. PMID: 25444636.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    17. Scleral intraocular pressure measurement in cadaver eyes pre- and postkeratoprosthesis implantation. Invest Ophthalmol Vis Sci. 2014 Apr 09; 55(4):2244-50. Lin CC, Chen A, Jeng BH, Porco TC, Ou Y, Han Y. PMID: 24557348.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Development of a resident training module for systematic optic disc evaluation in glaucoma. J Glaucoma. 2012 Dec; 21(9):601-7. Law SK, Tamboli DA, Ou Y, Giaconi JA, Caprioli J. PMID: 21602706.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis. Ophthalmic Epidemiol. 2012 Oct; 19(5):285-92. Ou Y, Grossman DS, Lee PP, Sloan FA. PMID: 22978529.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    20. Surgical management of pediatric glaucoma. Dev Ophthalmol. 2012; 50:157-72. Ou Y, Caprioli J. PMID: 22517182.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. A critical appraisal and comparison of the quality and recommendations of glaucoma clinical practice guidelines. Ophthalmology. 2011 Jun; 118(6):1017-23. Ou Y, Goldberg I, Migdal C, Lee PP. PMID: 21507487.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    22. Outcomes of Ahmed glaucoma valve implantation in children with primary congenital glaucoma. Arch Ophthalmol. 2009 Nov; 127(11):1436-41. Ou Y, Yu F, Law SK, Coleman AL, Caprioli J. PMID: 19901208.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    23. Transcriptional modification by a CASK-interacting nucleosome assembly protein. Neuron. 2004 Apr 08; 42(1):113-28. Wang GS, Hong CJ, Yen TY, Huang HY, Ou Y, Huang TN, Jung WG, Kuo TY, Sheng M, Wang TF, Hsueh YP. PMID: 15066269.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    24. The transmembrane domains of ectoapyrase (CD39) affect its enzymatic activity and quaternary structure. J Biol Chem. 1998 Sep 18; 273(38):24814-21. Wang TF, Ou Y, Guidotti G. PMID: 9733785.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
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