Dan Schwartz, MD

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address490 Illinois Street
San Francisco CA 94158
Phone415-476-1887
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1984 Medicine
    Johns Hopkins Hospital, Wilmer Eye InstituteResidency1988Ophthalmology
    Medical College of WisconsinFellowship1989Vitreoretinal Surgery
    Bascom Palmer Eye InstituteFellowship1990Medical Retina

    Collapse Overview 
    Collapse Overview
    Dr. Schwartz joined the UCSF Department of Ophthalmology in 1990. He serves as Director of the Retina Division at the San Francisco VA Medical Center.

    His research focuses on developing new therapies and diagnostics for eye disease.

    With Drs. Robert Grubbs and Julia Kornfield at Caltech, he co-invented the Light Adjustable Lens, an intraocular lens whose power can be adjusted non-invasively using light during the post-operative period. FDA Approved in 2017, it optimizes vision without spectacles for patients who have had cataract surgery.

    With Drs. Scott Fraser and Jeff Fingler, he co-invented OCT angiography, a non-invasive means of imaging the retinal and choroidal vasculature. OCT angiography is playing an increasingly important role in diagnosis and management of age-related macular degeneration, diabetic retinopathy, and other common retinovascular diseases.

    Dr. Schwartz’s current efforts are directed at developing novel therapies for age-related macular degeneration and myopic macular degeneration.

    He is grateful for the research support he has received from the NIH, Research Prevent Blindness, the Pritzker Family Fund, the Hellman Foundation, the Larry L. Hillblom Foundation, and many of his patients.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Choriocapillaris Changes in Myopic Macular Degeneration. Transl Vis Sci Technol. 2022 Feb 01; 11(2):37. Li J, Zhou H, Feinstein M, Wong J, Wang RK, Chan L, Dai Y, Porco T, Duncan JL, Schwartz DM. PMID: 35201337; PMCID: PMC8883151.
      View in: PubMed   Mentions:
    2. Correlation Between Localized Choriocapillaris Perfusion and Macular Function in Eyes with Geographic Atrophy. Am J Ophthalmol. 2022 02; 234:174-182. Rinella NT, Zhou H, Wong J, Zhang Q, Nattagh K, Porco TC, Wang RK, Schwartz DM, Duncan JL. PMID: 34437870.
      View in: PubMed   Mentions:    Fields:    
    3. CENTRAL RETINAL ARTERY OCCLUSION WITH CILIORETINAL ARTERY SPARING AFTER LASER-ASSISTED IN SITU KERATOMILEUSIS. Retin Cases Brief Rep. 2021 Jul 01; 15(4):436-440. Francis AW, Zhu I, Borirakchanyavat S, Schwartz DM, Hwang DG. PMID: 30106799.
      View in: PubMed   Mentions:    Fields:    
    4. BILATERAL ENTEROCOCCUS FAECALIS ENDOPHTHALMITIS WITH MULTIPLE RECURRENCES. Retin Cases Brief Rep. 2021 Jan 01; 15(1):38-42. Aderman CM, Chao DL, Obeid A, Schwartz DM, Bhisitkul RB, Chiu CS. PMID: 29489562.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    5. OCT Angiography to Predict Geographic Atrophy Progression using Choriocapillaris Flow Void as a Biomarker. Transl Vis Sci Technol. 2020 06; 9(7):6. Nattagh K, Zhou H, Rinella N, Zhang Q, Dai Y, Foote KG, Keiner C, Deiner M, Duncan JL, Porco TC, Wang RK, Schwartz DM. PMID: 32832213; PMCID: PMC7414606.
      View in: PubMed   Mentions: 2  Translation:Humans
    6. Automated morphometric measurement of the retinal pigment epithelium complex and choriocapillaris using swept source OCT. Biomed Opt Express. 2020 Apr 01; 11(4):1834-1850. Zhou H, Dai Y, Gregori G, Rosenfeld PR, Duncan JL, Schwartz DM, Wang RK. PMID: 32341851; PMCID: PMC7173887.
      View in: PubMed   Mentions: 3  
    7. Quantifying Choriocapillaris Flow Voids in Patients With Geographic Atrophy Using Swept-Source OCT Angiography. Ophthalmic Surg Lasers Imaging Retina. 2019 09 01; 50(9):e229-e235. Rinella NT, Zhou H, Zhang Q, Keiner C, Oldenburg CE, Duncan JL, Wang RK, Schwartz DM. PMID: 31589763.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography. Clin Ophthalmol. 2019; 13:1613-1620. Keiner CM, Zhou H, Zhang Q, Wang RK, Rinella NT, Oldenburg CE, Duncan JL, Schwartz DM. PMID: 31692580; PMCID: PMC6717151.
      View in: PubMed   Mentions: 3  
    9. OCT Angiography and Cone Photoreceptor Imaging in Geographic Atrophy. Invest Ophthalmol Vis Sci. 2018 12 03; 59(15):5985-5992. Qin J, Rinella N, Zhang Q, Zhou H, Wong J, Deiner M, Roorda A, Porco TC, Wang RK, Schwartz DM, Duncan JL. PMID: 30572343; PMCID: PMC6306079.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate. J Biomed Opt. 2017 Oct; 22(10):1-14. Poddar R, Migacz JV, Schwartz DM, Werner JS, Gorczynska I. PMID: 29090534; PMCID: PMC9062069.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    11. POLYPOIDAL CHOROIDAL VASCULOPATHY: A CLINICOPATHOLOGIC STUDY. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S128-S131. Moussa K, Bloomer MM, Schwartz DM, Pan CK, Toy BC, Crawford JB, Afshar AR. PMID: 27930435.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Acute Bilateral Vision Loss. JAMA Ophthalmol. 2016 Feb; 134(2):235-6. Aderman CM, Schwartz DM. PMID: 26720638.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography. Clin Ophthalmol. 2015; 9:1299-305. McClintic SM, Kim DY, Fingler J, Garcia S, Zawadzki RJ, Morse LS, Park SS, Fraser SE, Werner JS, Ruggiero JP, Schwartz DM. PMID: 26203220; PMCID: PMC4508080.
      View in: PubMed   Mentions: 3  
    14. Same-Day Versus Next-Day Repair of Fovea-Threatening Primary Rhegmatogenous Retinal Detachments. Semin Ophthalmol. 2016; 31(3):219-25. Gorovoy IR, Porco TC, Bhisitkul RB, de Juan E, Schwartz DM, Stewart JM. PMID: 25081305.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Dexamethasone intravitreal implant trapped at the macula in a silicone oil-filled eye. Ophthalmology. 2013 Dec; 120(12):2748-2749.e1. Afshar AR, Loh AR, Pongsachareonnont P, Schwartz DM, Stewart JM. PMID: 24246828.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Phase-variance optical coherence tomography: a technique for noninvasive angiography. Ophthalmology. 2014 Jan; 121(1):180-187. Schwartz DM, Fingler J, Kim DY, Zawadzki RJ, Morse LS, Park SS, Fraser SE, Werner JS. PMID: 24156929; PMCID: PMC4190463.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    17. Spontaneous epiretinal membrane separation. Oman J Ophthalmol. 2013 Jan; 6(1):56-7. Kolomeyer AM, Schwartz DM. PMID: 23772129; PMCID: PMC3678201.
      View in: PubMed   Mentions: 3  
    18. In vivo human choroidal vascular pattern visualization using high-speed swept-source optical coherence tomography at 1060 nm. Invest Ophthalmol Vis Sci. 2012 Apr 30; 53(4):2337-48. Motaghiannezam R, Schwartz DM, Fraser SE. PMID: 22410568.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    19. Microcystic macular oedema in multiple sclerosis is associated with disease severity. Brain. 2012 Jun; 135(Pt 6):1786-93. Gelfand JM, Nolan R, Schwartz DM, Graves J, Green AJ. PMID: 22539259; PMCID: PMC3359753.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    20. Noninvasive imaging of the foveal avascular zone with high-speed, phase-variance optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Jan 05; 53(1):85-92. Kim DY, Fingler J, Zawadzki RJ, Park SS, Morse LS, Schwartz DM, Fraser SE, Werner JS. PMID: 22125275; PMCID: PMC3292386.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    21. In vivo volumetric imaging of human retinal circulation with phase-variance optical coherence tomography. Biomed Opt Express. 2011 Jun 01; 2(6):1504-13. Kim DY, Fingler J, Werner JS, Schwartz DM, Fraser SE, Zawadzki RJ. PMID: 21698014; PMCID: PMC3114219.
      View in: PubMed   Mentions: 91  
    22. Corneal endothelial safety after ultraviolet light treatment of the light-adjustable intraocular lens. J Cataract Refract Surg. 2011 Feb; 37(2):324-7. Lichtinger A, Sandstedt CA, Padilla K, Schwartz DM, Chayet AS. PMID: 21241916.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Correction of astigmatism after cataract surgery using the light adjustable lens: a 1-year follow-up pilot study. J Refract Surg. 2011 Sep; 27(9):639-42. Lichtinger A, Sandstedt CA, Schwartz DM, Chayet AS. PMID: 21243977.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Hypothermia reduces secretion of vascular endothelial growth factor by cultured retinal pigment epithelial cells. Br J Ophthalmol. 2010 Dec; 94(12):1678-83. Coassin M, Duncan KG, Bailey KR, Singh A, Schwartz DM. PMID: 20805126.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. An in vitro intact globe expansion method for evaluation of cross-linking treatments. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3120-8. Mattson MS, Huynh J, Wiseman M, Coassin M, Kornfield JA, Schwartz DM. PMID: 20071684; PMCID: PMC2891471.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    26. Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium. Br J Ophthalmol. 2009 Aug; 93(8):1116-20. Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL. PMID: 19304587; PMCID: PMC3541028.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    27. Phase-contrast OCT imaging of transverse flows in the mouse retina and choroid. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):5055-9. Fingler J, Readhead C, Schwartz DM, Fraser SE. PMID: 18566457.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    28. High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture. Br J Ophthalmol. 2006 May; 90(5):616-20. Ishida BY, Duncan KG, Bailey KR, Kane JP, Schwartz DM. PMID: 16622093; PMCID: PMC1857047.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Light-adjustable lens: customizing correction for multifocality and higher-order aberrations. Trans Am Ophthalmol Soc. 2006; 104:29-39. Sandstedt CA, Chang SH, Grubbs RH, Schwartz DM. PMID: 17471323; PMCID: PMC1809908.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration. Am J Ophthalmol. 2004 Apr; 137(4):615-24. Wilson HL, Schwartz DM, Bhatt HR, McCulloch CE, Duncan JL. PMID: 15059698.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    31. Light-adjustable lens: development of in vitro nomograms. Trans Am Ophthalmol Soc. 2004; 102:67-72; discussion 72-4. Schwartz DM, Sandstedt CA, Chang SH, Kornfield JA, Grubbs RH. PMID: 15747746; PMCID: PMC1280088.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Complications of hydrogel explants used in scleral buckling surgery. Am J Ophthalmol. 2004 Jan; 137(1):96-100. Kearney JJ, Lahey JM, Borirakchanyavat S, Schwartz DM, Wilson D, Tanaka SC, Robins D. PMID: 14700650.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    33. Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. J Lipid Res. 2004 Feb; 45(2):263-71. Ishida BY, Bailey KR, Duncan KG, Chalkley RJ, Burlingame AL, Kane JP, Schwartz DM. PMID: 14594998.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    34. Light-adjustable lens. Trans Am Ophthalmol Soc. 2003; 101:417-36. Schwartz DM. PMID: 14971588; PMCID: PMC1358999.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    35. Intraoperative neurophysiologic detection of iatrogenic C5 nerve root injury during laminectomy for cervical compression myelopathy. Spine (Phila Pa 1976). 2002 Nov 15; 27(22):2499-502. Fan D, Schwartz DM, Vaccaro AR, Hilibrand AS, Albert TJ. PMID: 12435981.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCTClinical Trials
    36. Human retinal pigment epithelial cells express scavenger receptors BI and BII. Biochem Biophys Res Commun. 2002 Apr 12; 292(4):1017-22. Duncan KG, Bailey KR, Kane JP, Schwartz DM. PMID: 11944916.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    37. Corneal toxicity of intraocular hyaluronidase. J Ocul Pharmacol Ther. 2002 Feb; 18(1):89-97. Jumper JM, McCauley MB, Equi RA, Duncan KG, Duncan J, Schwartz DM. PMID: 11858619.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    38. Saxitoxin: an anesthetic of the deepithelialized rabbit cornea. Cornea. 2001 Aug; 20(6):639-42. Duncan KG, Duncan JL, Schwartz DM. PMID: 11473167.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    39. Post implantation adjustable intraocular lenses. Ophthalmol Clin North Am. 2001 Jun; 14(2):339-45, viii. Schwartz DM, Jethmalani JM, Sandstedt CA, Kornfield JA, Grubbs RH. PMID: 11406429.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    40. An economic analysis of interventions for diabetes. Diabetes Care. 2000 Mar; 23(3):390-404. Klonoff DC, Schwartz DM. PMID: 10868871.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    41. Visual and anatomic outcomes associated with posterior segment complications after ganciclovir implant procedures in patients with AIDS and cytomegalovirus retinitis. Am J Ophthalmol. 1999 Mar; 127(3):288-93. Lim JI, Wolitz RA, Dowling AH, Bloom HR, Irvine AR, Schwartz DM. PMID: 10088738.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    42. Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors. Graefes Arch Clin Exp Ophthalmol. 1999 Mar; 237(3):231-40. Duncan KG, Jumper MD, Ribeiro RC, Bailey KR, Yen PM, Sugawara A, Patel A, Stern R, Chin WW, Baxter JD, Schwartz DM. PMID: 10090587.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    43. The human fetal retinal pigment epithelium: A target tissue for thyroid hormones. Ophthalmic Res. 1999; 31(6):399-406. Duncan KG, Bailey KR, Baxter JD, Schwartz DM. PMID: 10474068.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    44. Hyaluronan and CD44 in the human cornea and limbal conjunctiva. Exp Eye Res. 1998 Oct; 67(4):481-4. Lerner LE, Schwartz DM, Hwang DG, Howes EL, Stern R. PMID: 9820796.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    45. Tetrodotoxin: anesthetic activity in the de-epithelialized cornea. Graefes Arch Clin Exp Ophthalmol. 1998 Oct; 236(10):790-4. Schwartz DM, Duncan KG, Fields HL, Jones MR. PMID: 9801896.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    46. Experimental study of tetrodotoxin, a long-acting topical anesthetic. Am J Ophthalmol. 1998 Apr; 125(4):481-7. Schwartz DM, Fields HL, Duncan KG, Duncan JL, Jones MR. PMID: 9559733.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    47. Experimental use of tetrodotoxin for corneal pain after excimer laser keratectomy. Cornea. 1998 Mar; 17(2):196-9. Schwartz DM, Duncan KG, Duncan JL. PMID: 9520198.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    48. Expression of CD44 isoforms in cultured human trabecular meshwork cells. Ophthalmic Res. 1998; 30(5):314-20. Jumper MD, Stern R, Lui GM, Formby B, Schwartz DM. PMID: 9704335.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    49. Aqueous hyaluronic acid concentration: comparison in pediatric and adult patients. Curr Eye Res. 1997 Oct; 16(10):1069-71. Jumper JM, Chang DF, Hoyt CS, Hall JL, Stern R, Schwartz DM. PMID: 9330862.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Hyaluronan polymer size modulates intraocular pressure. J Ocul Pharmacol Ther. 1997 Aug; 13(4):289-95. Equi RA, Jumper M, Cha C, Stern R, Schwartz DM. PMID: 9261764.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    51. Corneal endothelial hyaluronidase: a role in anterior chamber hyaluronic acid catabolism. Cornea. 1997 Mar; 16(2):188-91. Schwartz DM, Jumper MD, Lui GM, Dang S, Schuster S, Stern R. PMID: 9071532.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    52. Guarded microvitreoretinal blade. Arch Ophthalmol. 1996 Dec; 114(12):1524-5. Schwartz DM. PMID: 8953989.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Human vitreous hyaluronidase: isolation and characterization. Curr Eye Res. 1996 Dec; 15(12):1156-62. Schwartz DM, Shuster S, Jumper MD, Chang A, Stern R. PMID: 9018429.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    54. New therapies for cytomegalovirus retinitis. Int Ophthalmol Clin. 1996; 36(2):1-9. Schwartz DM. PMID: 8950629.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis. Am J Ophthalmol. 1995 Aug; 120(2):219-26. McCann JD, Margolis TP, Wong MG, Kuppermann BD, Luckie AP, Schwartz DM, Irvine AR, Ai E. PMID: 7639306.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    56. Management of traumatic hemorrhagic retinal detachment with pars plana vitrectomy. Arch Ophthalmol. 1990 Sep; 108(9):1281-6. Han DP, Mieler WF, Schwartz DM, Abrams GW. PMID: 2205184.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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