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Dan Schwartz, MD

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Phone415-476-1152
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1984 Medicine
    Johns Hopkins Hospital, Wilmer Eye InstituteResidency1988Ophthalmology
    Medical College of WisconsinFellowship1989Vitreoretinal Surgery
    Bascom Palmer Eye InstituteFellowship1990Medical Retina

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    Collapse Overview
    Dr. Schwartz joined the UCSF Department of Ophthalmology in 1990. He is the Shirley Reich Professor of Ophthalmology and directs the Retina Division. He also serves as Director of the Retina Division at the San Francisco VA Medical Center.

    His research focuses on developing new therapies and diagnostics for eye disease.

    With Drs. Robert Grubbs and Julia Kornfield at Caltech, he co-invented the Light Adjustable Lens, an intraocular lens whose power can be adjusted non-invasively using light during the post-operative period. FDA Approved in 2017, it optimizes vision without spectacles for patients who have had cataract surgery.

    With Drs. Scott Fraser and Jeff Fingler, he co-invented OCT angiography, a non-invasive means of imaging the retinal and choroidal vasculature. OCT angiography is playing an increasingly important role in diagnosis and management of age-related macular degeneration, diabetic retinopathy, and other common retinovascular diseases.

    Dr. Schwartz’s current efforts are directed at developing novel therapies for age-related macular degeneration and myopic macular degeneration.

    He is grateful for the research support he has received from the NIH, Research Prevent Blindness, the Pritzker Family Fund, the Hellman Foundation, the Larry L. Hillblom Foundation, and many of his patients.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rinella NT, Zhou H, Zhang Q, Keiner C, Oldenburg CE, Duncan JL, Wang RK, Schwartz DM. Quantifying Choriocapillaris Flow Voids in Patients With Geographic Atrophy Using Swept-Source OCT Angiography. Ophthalmic Surg Lasers Imaging Retina. 2019 09 01; 50(9):e229-e235. PMID: 31589763.
      View in: PubMed
    2. Keiner CM, Zhou H, Zhang Q, Wang RK, Rinella NT, Oldenburg CE, Duncan JL, Schwartz DM. Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography. Clin Ophthalmol. 2019; 13:1613-1620. PMID: 31692580.
      View in: PubMed
    3. Qin J, Rinella N, Zhang Q, Zhou H, Wong J, Deiner M, Roorda A, Porco TC, Wang RK, Schwartz DM, Duncan JL. OCT Angiography and Cone Photoreceptor Imaging in Geographic Atrophy. Invest Ophthalmol Vis Sci. 2018 12 03; 59(15):5985-5992. PMID: 30572343.
      View in: PubMed
    4. Francis AW, Zhu I, Borirakchanyavat S, Schwartz DM, Hwang DG. CENTRAL RETINAL ARTERY OCCLUSION WITH CILIORETINAL ARTERY SPARING AFTER LASER-ASSISTED IN SITU KERATOMILEUSIS. Retin Cases Brief Rep. 2018 Aug 10. PMID: 30106799.
      View in: PubMed
    5. Aderman CM, Chao DL, Obeid A, Schwartz DM, Bhisitkul RB, Chiu CS. BILATERAL ENTEROCOCCUS FAECALIS ENDOPHTHALMITIS WITH MULTIPLE RECURRENCES. Retin Cases Brief Rep. 2018 Feb 27. PMID: 29489562.
      View in: PubMed
    6. Poddar R, Migacz JV, Schwartz DM, Werner JS, Gorczynska I. Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate. J Biomed Opt. 2017 Oct; 22(10):1-14. PMID: 29090534.
      View in: PubMed
    7. Moussa K, Bloomer MM, Schwartz DM, Pan CK, Toy BC, Crawford JB, Afshar AR. POLYPOIDAL CHOROIDAL VASCULOPATHY: A CLINICOPATHOLOGIC STUDY. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S128-S131. PMID: 27930435.
      View in: PubMed
    8. Aderman CM, Schwartz DM. Acute Bilateral Vision Loss. JAMA Ophthalmol. 2016 Feb; 134(2):235-6. PMID: 26720638.
      View in: PubMed
    9. McClintic SM, Kim DY, Fingler J, Garcia S, Zawadzki RJ, Morse LS, Park SS, Fraser SE, Werner JS, Ruggiero JP, Schwartz DM. Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography. Clin Ophthalmol. 2015; 9:1299-305. PMID: 26203220.
      View in: PubMed
    10. Gorovoy IR, Porco TC, Bhisitkul RB, de Juan E, Schwartz DM, Stewart JM. Same-Day Versus Next-Day Repair of Fovea-Threatening Primary Rhegmatogenous Retinal Detachments. Semin Ophthalmol. 2016; 31(3):219-25. PMID: 25081305.
      View in: PubMed
    11. Afshar AR, Loh AR, Pongsachareonnont P, Schwartz DM, Stewart JM. Dexamethasone intravitreal implant trapped at the macula in a silicone oil-filled eye. Ophthalmology. 2013 Dec; 120(12):2748-2749.e1. PMID: 24246828.
      View in: PubMed
    12. Schwartz DM, Fingler J, Kim DY, Zawadzki RJ, Morse LS, Park SS, Fraser SE, Werner JS. Phase-variance optical coherence tomography: a technique for noninvasive angiography. Ophthalmology. 2014 Jan; 121(1):180-187. PMID: 24156929.
      View in: PubMed
    13. Kolomeyer AM, Schwartz DM. Spontaneous epiretinal membrane separation. Oman J Ophthalmol. 2013 Jan; 6(1):56-7. PMID: 23772129.
      View in: PubMed
    14. Motaghiannezam R, Schwartz DM, Fraser SE. In vivo human choroidal vascular pattern visualization using high-speed swept-source optical coherence tomography at 1060 nm. Invest Ophthalmol Vis Sci. 2012 Apr 30; 53(4):2337-48. PMID: 22410568.
      View in: PubMed
    15. Gelfand JM, Nolan R, Schwartz DM, Graves J, Green AJ. Microcystic macular oedema in multiple sclerosis is associated with disease severity. Brain. 2012 Jun; 135(Pt 6):1786-93. PMID: 22539259.
      View in: PubMed
    16. Kim DY, Fingler J, Zawadzki RJ, Park SS, Morse LS, Schwartz DM, Fraser SE, Werner JS. Noninvasive imaging of the foveal avascular zone with high-speed, phase-variance optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Jan 05; 53(1):85-92. PMID: 22125275.
      View in: PubMed
    17. Kim DY, Fingler J, Werner JS, Schwartz DM, Fraser SE, Zawadzki RJ. In vivo volumetric imaging of human retinal circulation with phase-variance optical coherence tomography. Biomed Opt Express. 2011 Jun 01; 2(6):1504-13. PMID: 21698014.
      View in: PubMed
    18. Lichtinger A, Sandstedt CA, Padilla K, Schwartz DM, Chayet AS. Corneal endothelial safety after ultraviolet light treatment of the light-adjustable intraocular lens. J Cataract Refract Surg. 2011 Feb; 37(2):324-7. PMID: 21241916.
      View in: PubMed
    19. Lichtinger A, Sandstedt CA, Schwartz DM, Chayet AS. Correction of astigmatism after cataract surgery using the light adjustable lens: a 1-year follow-up pilot study. J Refract Surg. 2011 Sep; 27(9):639-42. PMID: 21243977.
      View in: PubMed
    20. Coassin M, Duncan KG, Bailey KR, Singh A, Schwartz DM. Hypothermia reduces secretion of vascular endothelial growth factor by cultured retinal pigment epithelial cells. Br J Ophthalmol. 2010 Dec; 94(12):1678-83. PMID: 20805126.
      View in: PubMed
    21. Mattson MS, Huynh J, Wiseman M, Coassin M, Kornfield JA, Schwartz DM. An in vitro intact globe expansion method for evaluation of cross-linking treatments. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3120-8. PMID: 20071684.
      View in: PubMed
    22. Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL. Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium. Br J Ophthalmol. 2009 Aug; 93(8):1116-20. PMID: 19304587.
      View in: PubMed
    23. Fingler J, Readhead C, Schwartz DM, Fraser SE. Phase-contrast OCT imaging of transverse flows in the mouse retina and choroid. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):5055-9. PMID: 18566457.
      View in: PubMed
    24. Ishida BY, Duncan KG, Bailey KR, Kane JP, Schwartz DM. High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture. Br J Ophthalmol. 2006 May; 90(5):616-20. PMID: 16622093.
      View in: PubMed
    25. Sandstedt CA, Chang SH, Grubbs RH, Schwartz DM. Light-adjustable lens: customizing correction for multifocality and higher-order aberrations. Trans Am Ophthalmol Soc. 2006; 104:29-39. PMID: 17471323.
      View in: PubMed
    26. Wilson HL, Schwartz DM, Bhatt HR, McCulloch CE, Duncan JL. Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration. Am J Ophthalmol. 2004 Apr; 137(4):615-24. PMID: 15059698.
      View in: PubMed
    27. Schwartz DM, Sandstedt CA, Chang SH, Kornfield JA, Grubbs RH. Light-adjustable lens: development of in vitro nomograms. Trans Am Ophthalmol Soc. 2004; 102:67-72; discussion 72-4. PMID: 15747746.
      View in: PubMed
    28. Kearney JJ, Lahey JM, Borirakchanyavat S, Schwartz DM, Wilson D, Tanaka SC, Robins D. Complications of hydrogel explants used in scleral buckling surgery. Am J Ophthalmol. 2004 Jan; 137(1):96-100. PMID: 14700650.
      View in: PubMed
    29. Ishida BY, Bailey KR, Duncan KG, Chalkley RJ, Burlingame AL, Kane JP, Schwartz DM. Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. J Lipid Res. 2004 Feb; 45(2):263-71. PMID: 14594998.
      View in: PubMed
    30. Schwartz DM. Light-adjustable lens. Trans Am Ophthalmol Soc. 2003; 101:417-36. PMID: 14971588.
      View in: PubMed
    31. Duncan KG, Bailey KR, Kane JP, Schwartz DM. Human retinal pigment epithelial cells express scavenger receptors BI and BII. Biochem Biophys Res Commun. 2002 Apr 12; 292(4):1017-22. PMID: 11944916.
      View in: PubMed
    32. Jumper JM, McCauley MB, Equi RA, Duncan KG, Duncan J, Schwartz DM. Corneal toxicity of intraocular hyaluronidase. J Ocul Pharmacol Ther. 2002 Feb; 18(1):89-97. PMID: 11858619.
      View in: PubMed
    33. Duncan KG, Duncan JL, Schwartz DM. Saxitoxin: an anesthetic of the deepithelialized rabbit cornea. Cornea. 2001 Aug; 20(6):639-42. PMID: 11473167.
      View in: PubMed
    34. Schwartz DM, Jethmalani JM, Sandstedt CA, Kornfield JA, Grubbs RH. Post implantation adjustable intraocular lenses. Ophthalmol Clin North Am. 2001 Jun; 14(2):339-45, viii. PMID: 11406429.
      View in: PubMed
    35. Lim JI, Wolitz RA, Dowling AH, Bloom HR, Irvine AR, Schwartz DM. Visual and anatomic outcomes associated with posterior segment complications after ganciclovir implant procedures in patients with AIDS and cytomegalovirus retinitis. Am J Ophthalmol. 1999 Mar; 127(3):288-93. PMID: 10088738.
      View in: PubMed
    36. Duncan KG, Jumper MD, Ribeiro RC, Bailey KR, Yen PM, Sugawara A, Patel A, Stern R, Chin WW, Baxter JD, Schwartz DM. Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors. Graefes Arch Clin Exp Ophthalmol. 1999 Mar; 237(3):231-40. PMID: 10090587.
      View in: PubMed
    37. Duncan KG, Bailey KR, Baxter JD, Schwartz DM. The human fetal retinal pigment epithelium: A target tissue for thyroid hormones. Ophthalmic Res. 1999; 31(6):399-406. PMID: 10474068.
      View in: PubMed
    38. Lerner LE, Schwartz DM, Hwang DG, Howes EL, Stern R. Hyaluronan and CD44 in the human cornea and limbal conjunctiva. Exp Eye Res. 1998 Oct; 67(4):481-4. PMID: 9820796.
      View in: PubMed
    39. Schwartz DM, Duncan KG, Fields HL, Jones MR. Tetrodotoxin: anesthetic activity in the de-epithelialized cornea. Graefes Arch Clin Exp Ophthalmol. 1998 Oct; 236(10):790-4. PMID: 9801896.
      View in: PubMed
    40. Schwartz DM, Fields HL, Duncan KG, Duncan JL, Jones MR. Experimental study of tetrodotoxin, a long-acting topical anesthetic. Am J Ophthalmol. 1998 Apr; 125(4):481-7. PMID: 9559733.
      View in: PubMed
    41. Schwartz DM, Duncan KG, Duncan JL. Experimental use of tetrodotoxin for corneal pain after excimer laser keratectomy. Cornea. 1998 Mar; 17(2):196-9. PMID: 9520198.
      View in: PubMed
    42. Jumper MD, Stern R, Lui GM, Formby B, Schwartz DM. Expression of CD44 isoforms in cultured human trabecular meshwork cells. Ophthalmic Res. 1998; 30(5):314-20. PMID: 9704335.
      View in: PubMed
    43. Jumper JM, Chang DF, Hoyt CS, Hall JL, Stern R, Schwartz DM. Aqueous hyaluronic acid concentration: comparison in pediatric and adult patients. Curr Eye Res. 1997 Oct; 16(10):1069-71. PMID: 9330862.
      View in: PubMed
    44. Equi RA, Jumper M, Cha C, Stern R, Schwartz DM. Hyaluronan polymer size modulates intraocular pressure. J Ocul Pharmacol Ther. 1997 Aug; 13(4):289-95. PMID: 9261764.
      View in: PubMed
    45. Schwartz DM, Jumper MD, Lui GM, Dang S, Schuster S, Stern R. Corneal endothelial hyaluronidase: a role in anterior chamber hyaluronic acid catabolism. Cornea. 1997 Mar; 16(2):188-91. PMID: 9071532.
      View in: PubMed
    46. Schwartz DM. Guarded microvitreoretinal blade. Arch Ophthalmol. 1996 Dec; 114(12):1524-5. PMID: 8953989.
      View in: PubMed
    47. Schwartz DM, Shuster S, Jumper MD, Chang A, Stern R. Human vitreous hyaluronidase: isolation and characterization. Curr Eye Res. 1996 Dec; 15(12):1156-62. PMID: 9018429.
      View in: PubMed
    48. Schwartz DM. New therapies for cytomegalovirus retinitis. Int Ophthalmol Clin. 1996; 36(2):1-9. PMID: 8950629.
      View in: PubMed
    49. McCann JD, Margolis TP, Wong MG, Kuppermann BD, Luckie AP, Schwartz DM, Irvine AR, Ai E. A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis. Am J Ophthalmol. 1995 Aug; 120(2):219-26. PMID: 7639306.
      View in: PubMed
    50. Han DP, Mieler WF, Schwartz DM, Abrams GW. Management of traumatic hemorrhagic retinal detachment with pars plana vitrectomy. Arch Ophthalmol. 1990 Sep; 108(9):1281-6. PMID: 2205184.
      View in: PubMed
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