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Chris Lau, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-750-2098
Emailchris.lau@ucsf.edu
ORCID ORCID Icon0000-0002-9119-7050 Additional info
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    Collapse Biography 
    Collapse Education and Training
    HARPUR COLLEGE-SUNY, BINGHAMTONB.A.06/1973CHEMISTRY
    MD ANDERSON CANCER CENTER-UTHEALTH, HOUSTONM.S.06/1976CELL BIOLOGY
    MD ANDERSON CANCER CENTER-UTHEALTH, HOUSTONPH.D.06/1979GENETICS

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Research Career Scientist Award
    Department of Veterans Affairs 1IK6BX004854Oct 1, 2019 - Sep 30, 2024
    Role: Principal Investigator
    Single-Cell Next-Generation Sequencing Library Preparation System
    Department of Veterans Affairs 1IS1BX005014-01Sep 1, 2019 - Sep 30, 2020
    Role: Principal Investigator
    Role Description: This award provides fund to purchase a 10x Genomics Chromium System for preparation of single-cell next-generation sequencing libraries.
    Molecular Mechanisms of a Male-Specific Positive Feedback Loop in Liver Cancer
    Department of Veterans Affairs 1IO1BX004446Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Role Description: The project studies the synergistic actions of the male-specific oncogene TSPY and the male sex hormone receptor and its constitutively active variants in oncogenesis and disease progression in hepatocellular carcinoma, and their contributions to male biases in liver cancer.
    The Genetic Basis of Sex Differences in Liver Cancer
    Department of Defense W81XWH-16-1-0488Aug 15, 2016 - Aug 14, 2019
    Role: Principal Investigator
    Role of genetic biomarkers in clinical assessment of prostate cancer
    VA IP1BX001604Oct 1, 2012 - Sep 30, 2016
    Role: Co-Investigator, Principal Investigator-Project 3
    Role of the Y-Located TSPY Gene in Human Oncogenesis
    NIH I01BX000865Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    Sex Chromosomes and Gender Disparity in HBV-Related Hepatocellular Carcinoma
    NIH R21CA152589Jul 23, 2010 - Jun 30, 2014
    Role: Principal Investigator
    Sex Chromosomes and Gender Disparity in HBV-Related Heaptocellular Carcinoma
    NIH R21CA152589Jul 1, 2010 - Jun 30, 2013
    Role: Principal Investigator
    Y Chromosome Regulation of Autism Susceptibility Genes
    Department of Defense Autism Research Program W81XWH-08-2-0070Jun 1, 2008 - May 31, 2010
    Role: PRINCIPAL INVESTIGATOR
    The Role of the Y-Located TSPY Gene in Prostatic Oncogenesis
    VA Merit GrantApr 1, 2006 - Sep 30, 2010
    Role: Principal Investigator
    Mitochondrial Structure and Reactive Oxygen Species in Mammary Oncogneesis
    Department of Defense Breast Cancer Research Program DAMD17-03-0247Apr 3, 2003 - Mar 31, 2006
    Role: PRINCIPAL INVESTIGATOR
    The Role of the Y-Located TSPY Gene in Prostatic Oncogenesis
    Department of Defense Prostate Cancer Research Program DAMD17-03-0081Feb 1, 2003 - Jan 31, 2006
    Role: PRINCIPAL INVESTIGATOR
    FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    NIH R01HD038117Jun 1, 2000 - Feb 28, 2007
    Role: Principal Investigator
    Roles of the Y Chromosome Genes in Prostate Cancer
    Department of Defense Prostate Cancer Research Program DAMD17-00-1-0039Jan 15, 2000 - Jan 14, 2004
    Role: PRINCIPAL INVESTIGATOR
    Molecular Genetics of Male Hypertension
    VA Merit GrantOct 1, 1998 - Sep 30, 2001
    Role: PRINCIPAL INVESTIGATOR
    INTERNATIONAL WORKSHOP ON HUMAN Y CHROMOSOME
    NIH R13HD035762Apr 1, 1997 - Mar 31, 1998
    Role: Principal Investigator
    RESEARCH CAREER SCIENTIST AWARD
    VA RESEARCH CAREER SCIENTISTApr 1, 1994 - Sep 30, 2019
    Role: PRINCIPAL INVESTIGATOR
    Molecular Biology of Myocardial Ischemia
    VA Merit GrantApr 1, 1994 - Mar 31, 1997
    Role: PRINCIPAL INVESTIGATOR
    INTERNATIONAL WORKSHOPS ON HUMAN Y CHROMOSOME
    NIH R13HG001065Apr 1, 1994 - Dec 31, 1996
    Role: Principal Investigator
    U.S.-Argentina Cooperative Science Program: Characterizationof Genes Involved in Sex Determination and Sex Reversal in Akodon (Cricetidae) Rodents
    NSF INT-9202155Aug 1, 1992 - Jul 31, 1995
    Role: Principal Investigator
    FUNCTIONS OF THE TESTIS DETERMINING GENES
    NIH R01HD027392Sep 1, 1990 - Apr 30, 1999
    Role: Principal Investigator
    Functions of Zinc Finger Genes on Sex Chromosomes
    NIH 1RO1HD27392Sep 1, 1990 - Aug 31, 1994
    Role: Principal Investigator
    MOLECULAR BIOLOGY OF THE MALE ENHANCED ANTIGEN GENES
    NIH R01HD024384May 1, 1988 - Apr 30, 1994
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Y chromosome in health and diseases. Cell Biosci. 2020; 10:97. Lau YC. PMID: 32817785.
      View in: PubMed   Mentions:
    2. Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis. Cancer Sci. 2020 May 30. Kido T, Tabatabai ZL, Chen X, Lau YC. PMID: 32473614.
      View in: PubMed   Mentions: 1     Fields:    
    3. Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis. Asian J Androl. 2019 May-Jun; 21(3):260-269. Lau YC, Li Y, Kido T. PMID: 29974883.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY. Hum Reprod. 2019 04 01; 34(4):770-779. Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Lau YC, Heidemann PH, Strowitzki T. PMID: 30753444.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression. Cell Biosci. 2019; 9:22. Kido T, Lau YC. PMID: 30867900.
      View in: PubMed   Mentions:
    6. The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner. Oncotarget. 2019 Feb 19; 10(15):1491-1506. Kido T, Li Y, Tanaka Y, Dahiya R, Chris Lau YF. PMID: 30863497.
      View in: PubMed   Mentions: 2     Fields:    
    7. Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice. Sci Rep. 2017 06 23; 7(1):4113. Kido T, Sun Z, Lau YC. PMID: 28646221.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    8. The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants. Hum Mol Genet. 2017 03 01; 26(5):901-912. Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC. PMID: 28169398.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    9. Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers. J Genet Genomics. 2016 10 20; 43(10):577-585. Kido T, Lau YC. PMID: 27771326.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells. Oncotarget. 2015 Jun 30; 6(18):16341-51. Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, Saini S, Deng G, Gill A, Wong DK, Shiina H, Nonomura N, Lau YF, Dahiya R, Tanaka Y. PMID: 26036629.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Roles of the Y chromosome genes in human cancers. Asian J Androl. 2015 May-Jun; 17(3):373-80. Kido T, Lau YF. PMID: 25814157.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    12. SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. Hum Mol Genet. 2015 Feb 01; 24(3):685-97. Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau YF. PMID: 25267720.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    13. The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation. Cell Rep. 2014 Aug 07; 8(3):723-33. Li Y, Zheng M, Lau YF. PMID: 25088423.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    14. The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. Hum Pathol. 2014 Sep; 45(9):1847-58. Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. PMID: 25017435.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    15. The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. Biochem Biophys Res Commun. 2014 Mar 28; 446(1):206-11. Kido T, Lau YF. PMID: 24583132.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer. Cell Biosci. 2014 Feb 17; 4(1):9. Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF. PMID: 24528896.
      View in: PubMed   Mentions:
    17. Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies. Methods Mol Biol. 2013; 1067:185-202. Zheng M, Li Y, Lau YF. PMID: 23975793.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. Methods Mol Biol. 2012; 825:3-16. Li Y, Taketo T, Lau YF. PMID: 22144232.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    19. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PLoS One. 2011; 6(7):e22979. Kido T, Ou JH, Lau YF. PMID: 21829568.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions. J Genet Genomics. 2011 May 20; 38(5):181-91. Kido T, Schubert S, Schmidtke J, Chris Lau YF. PMID: 21621739.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Syst Biol Reprod Med. 2011 Feb; 57(1-2):27-34. Lau YF, Li Y, Kido T. PMID: 21204751.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. Genes (Basel). 2010 Sep 14; 1(2):283-93. Kido T, Hatakeyama S, Ohyama C, Lau YF. PMID: 24710046.
      View in: PubMed   Mentions: 10     Fields:    
    23. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics. 2010 Feb 15; 26(4):585-6. Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. PMID: 20028690.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    24. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. J Biol Chem. 2009 Dec 18; 284(51):35670-80. Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ. PMID: 19850934.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    25. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J. 2009 Nov; 23(11):4029-38. Wu JB, Chen K, Li Y, Lau YF, Shih JC. PMID: 19661285.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    26. The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling. J Genet Genomics. 2009 Apr; 36(4):193-202. Lau YF, Li Y. PMID: 19376480.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    27. Developmental staging of male murine embryonic gonad by SAGE analysis. J Genet Genomics. 2009 Apr; 36(4):215-27. Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau YF, Chan WY. PMID: 19376482.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    28. Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth Defects Res C Embryo Today. 2009 Mar; 87(1):114-22. Lau YF, Li Y, Kido T. PMID: 19306348.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    29. The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein. Int J Cancer. 2008 Oct 01; 123(7):1573-85. Kido T, Lau YF. PMID: 18649364.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours. Int J Exp Pathol. 2008 Oct; 89(5):342-9. Li Y, Kido T, Luo J, Fukuda M, Dobrinski I, Lau YF. PMID: 18808526.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    31. TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities. Oncogene. 2008 Oct 16; 27(47):6141-50. Li Y, Lau YF. PMID: 18591933.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    32. PIAS1 interacts with and represses SOX9 transactivation activity. Mol Reprod Dev. 2007 Nov; 74(11):1446-55. Oh HJ, Kido T, Lau YF. PMID: 17440973.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. JKT-1 is not a human seminoma cell line. Int J Androl. 2007 Aug; 30(4):350-65. de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau YF, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. PMID: 17705808.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    34. Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. Clin Endocrinol (Oxf). 2007 Aug; 67(2):184-92. Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH. PMID: 17547684.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    35. Y Chromosome and Male Germ Cell Biology in Health and Diseases. 2007. LAU YFC CHAN WY.
    36. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. Hum Pathol. 2007 Oct; 38(10):1470-81. Li Y, Tabatabai ZL, Lee TL, Hatakeyama S, Ohyama C, Chan WY, Looijenga LH, Lau YF. PMID: 17521702.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    37. Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ. Urol Oncol. 2007 Mar-Apr; 25(2):141-6. Li Y, Vilain E, Conte F, Rajpert-De Meyts E, Lau YF. PMID: 17349529.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    38. The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones. Biochem Biophys Res Commun. 2006 Nov 10; 350(1):56-67. Kido T, Lau YF. PMID: 16996029.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    39. The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. Mol Cell Endocrinol. 2006 Sep 26; 257-258:35-46. Li Y, Oh HJ, Lau YF. PMID: 16904257.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    40. TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC Cancer. 2006 Jun 09; 6:154. Oram SW, Liu XX, Lee TL, Chan WY, Lau YF. PMID: 16762081.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    41. Structural characterization and expression studies of Dby and its homologs in the mouse. J Androl. 2006 Sep-Oct; 27(5):653-61. Vong QP, Li Y, Lau YF, Dym M, Rennert OM, Chan WY. PMID: 16728723.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    42. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J Pathol. 2006 May; 209(1):25-33. Hoei-Hansen CE, Sehested A, Juhler M, Lau YF, Skakkebaek NE, Laursen H, Rajpert-de Meyts E. PMID: 16456896.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    43. Germ cell lineage differentiation in non-seminomatous germ cell tumours. J Pathol. 2006 Feb; 208(3):395-400. Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau YF, Looijenga LH, Oosterhuis JW. PMID: 16273510.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    44. KRAB: a partner for SRY action on chromatin. Mol Cell Endocrinol. 2006 Mar 09; 247(1-2):47-52. Oh HJ, Lau YF. PMID: 16414182.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum Pathol. 2006 Jan; 37(1):101-11. Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau YF, Drop SL, Looijenga LH. PMID: 16360422.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    46. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis. 2005 Aug; 42(4):263-75. Kido T, Lau YF. PMID: 16035036.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    47. Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Dev Dyn. 2005 Jun; 233(2):612-22. Taketo T, Lee CH, Zhang J, Li Y, Lee CY, Lau YF. PMID: 15789443.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    48. Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. Prostate. 2005 Jun 01; 63(4):369-84. Williams K, Fernandez S, Stien X, Ishii K, Love HD, Lau YF, Roberts RL, Hayward SW. PMID: 15937962.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    49. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum Pathol. 2005 May; 36(5):512-21. Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau YF, Oosterhuis JW, Looijenga LH. PMID: 15948118.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    50. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod. 2005 Feb; 72(2):407-15. Oh HJ, Li Y, Lau YF. PMID: 15469996.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    51. Protein transduction as a strategy for evaluating important factors in mammalian sex determination and differentiation. Cytogenet Genome Res. 2003; 101(3-4):237-41. Li Y, Yue L, Taketo T, Lau YF. PMID: 14684989.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    52. Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer. Cytogenet Genome Res. 2003; 101(3-4):250-60. Lau YF, Lau HW, Kömüves LG. PMID: 14684991.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    53. Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal. J Exp Zool. 2001 Nov 01; 290(6):551-7. Liu WS, Nordqvist K, Lau YF, Fredga K. PMID: 11748603.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    54. Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals. J Exp Zool. 2001 Nov 01; 290(6):632-41. Xian M, Zhang J, Lau YF. PMID: 11748612.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    55. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. Hypertension. 2001 Apr; 37(4):1147-52. Kren V, Qi N, Krenova D, Zidek V, Sladká M, Jáchymová M, Míková B, Horky K, Bonne A, Van Lith HA, Van Zutphen BF, Lau YF, Pravenec M, St Lezin E. PMID: 11304517.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase. J Mol Cell Cardiol. 2000 Oct; 32(10):1779-86. Karliner JS, Honbo N, Epstein CJ, Xian M, Lau YF, Gray MO. PMID: 11013122.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    57. Expression analysis of thirty one Y chromosome genes in human prostate cancer. Mol Carcinog. 2000 Apr; 27(4):308-21. Lau YF, Zhang J. PMID: 10747295.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    58. The green fluorescent protein is an efficient biological marker for cardiac myocytes. J Mol Cell Cardiol. 1999 Dec; 31(12):2155-65. Xian M, Honbo N, Zhang J, Liew CC, Karliner JS, Lau YF. PMID: 10640443.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    59. In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Int J Dev Biol. 1999 May; 43(3):219-27. Zhang J, Coward P, Xian M, Lau YF. PMID: 10410901.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    60. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. Am J Hum Genet. 1999 Apr; 64(4):921-7. Lau YF. PMID: 10090875.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    61. Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes. Methods Enzymol. 1999; 303:349-80. Diatchenko L, Lukyanov S, Lau YF, Siebert PD. PMID: 10349654.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    62. Sry interactive proteins: implication for the mechanisms of sex determination. Cytogenet Cell Genet. 1998; 80(1-4):128-32. Lau YF, Zhang J. PMID: 9678346.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    63. The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor. Clin Cancer Res. 1997 Dec; 3(12 Pt 2):2571-80. Shimamura R, Fraizer GC, Trapman J, Saunders GF. PMID: 9815658.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    64. Cytogenetic and molecular studies of a familial paracentric inversion of Y chromosome present in a patient with ambiguous genitalia. Am J Med Genet. 1997 May 16; 70(2):134-7. Liou JD, Ma YY, Gibson LH, Su H, Charest N, Lau YF, Yang-Feng TL. PMID: 9128931.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    65. Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. Cytogenet Cell Genet. 1997; 79(1-2):1-20. Vogt PH, Affara N, Davey P, Hammer M, Jobling MA, Lau YF, Mitchell M, Schempp W, Tyler-Smith C, Williams G, Yen P, Rappold GA. PMID: 9533010.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    66. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6025-30. Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD. PMID: 8650213.
      View in: PubMed   Mentions: 620     Fields:    Translation:HumansCells
    67. Report of the Second International Workshop on Y Chromosome Mapping 1995. Cytogenet Cell Genet. 1996; 73(1-2):33-76. Affara N, Bishop C, Brown W, Cooke H, Davey P, Ellis N, Graves JM, Jones M, Mitchell M, Rappold G, Tyler-Smith C, Yen P, Lau YF. PMID: 8646888.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    68. Functional comparison of the Mus musculus molossinus and Mus musculus domesticus Sry genes. Mol Endocrinol. 1995 Dec; 9(12):1645-54. Dubin RA, Coward P, Lau YF, Ostrer H. PMID: 8614401.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    69. Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal. Nat Genet. 1994 Mar; 6(3):245-50. Coward P, Nagai K, Chen D, Thomas HD, Nagamine CM, Lau YF. PMID: 8012385.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    70. Report and abstracts of the First International Workshop on Y Chromosome Mapping 1994. Cambridge, England, April 2-5, 1994. Cytogenet Cell Genet. 1994; 67(4):359-402. Affara NA, Lau YF, Briggs H, Davey P, Jones MH, Khwaja O, Mitchell M, Sargent C. PMID: 7924456.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    71. A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids. Mol Cell Biol. 1993 Jul; 13(7):4323-30. Boissonneault G, Lau YF. PMID: 8321234.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    72. Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach. Am J Hum Genet. 1993 Jan; 52(1):24-38. Su H, Lau YF. PMID: 8434602.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    73. Molecular isolation and characterization of an expressed gene from the human Y chromosome. Hum Mol Genet. 1992 Dec; 1(9):717-26. Zhang JS, Yang-Feng TL, Muller U, Mohandas TK, de Jong PJ, Lau YF. PMID: 1284595.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    74. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Mol Reprod Dev. 1992 Nov; 33(3):252-8. Su H, Lau YF. PMID: 1449792.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    75. Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. J Reprod Immunol. 1992 Apr; 21(3):275-91. Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U. PMID: 1522559.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    76. Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal. Cytogenet Cell Genet. 1992; 60(1):48-54. Lau YF, Yang-Feng TL, Elder B, Fredga K, Wiberg UH. PMID: 1349859.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    77. The musculus-type Y chromosome of the laboratory mouse is of Asian origin. Mamm Genome. 1992; 3(2):84-91. Nagamine CM, Nishioka Y, Moriwaki K, Boursot P, Bonhomme F, Lau YF. PMID: 1352158.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    78. Molecular cloning of an acrosomal sperm antigen gene and the production of its recombinant protein for immunocontraceptive vaccine. Mol Reprod Dev. 1990 Mar; 25(3):302-8. Liu MS, Chan KM, Lau YF, Lee CY. PMID: 2331378.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    79. Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes. Cytogenet Cell Genet. 1990; 54(3-4):151-3. Leung WY, Lindgren V, Lau YF, Yang-Feng YL. PMID: 2265557.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    80. The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues. Genes Dev. 1990 Jan; 4(1):63-74. Nagamine CM, Chan K, Hake LE, Lau YF. PMID: 1968414.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    81. Stage-specific expression of the lactate dehydrogenase-X gene in adult and developing mouse testes. Mol Reprod Dev. 1990 Jan; 25(1):14-21. Jen J, Deschepper CF, Shackleford GM, Lee CY, Lau YF. PMID: 2393579.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    82. The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. Am J Hum Genet. 1989 Dec; 45(6):942-52. Lau YF, Chan KM. PMID: 2511751.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    83. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8462-6. Lau YF, Chan KM, Sparkes R. PMID: 2813404.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    84. A PCR artifact: generation of heteroduplexes. Am J Hum Genet. 1989 Aug; 45(2):337-9. Nagamine CM, Chan K, Lau YF. PMID: 2631699.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    85. Isolation and chromosomal localization of the human En-2 gene. Genomics. 1989 Apr; 4(3):225-31. Poole SJ, Law ML, Kao FT, Lau YF. PMID: 2565873.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    86. Chromosome mapping and expression of a putative testis-determining gene in mouse. Science. 1989 Jan 06; 243(4887):80-3. Nagamine CM, Chan KM, Kozak CA, Lau YF. PMID: 2563174.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    87. The anonymous PAS45 probe detects RFLPs in 13q31. Ann Genet. 1989; 32(2):73-7. Gross MS, Sefiani A, de Tand MF, Lau YF, Saidi-Mehtar N, Hors-Cayla MC, Frezal J, Van Cong N. PMID: 2569289.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    88. Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5. Somat Cell Mol Genet. 1988 Sep; 14(5):515-8. Kao FT, Wu KC, Law ML, Hartz JA, Lau YF. PMID: 3175768.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    89. Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):5894-8. Kim YK, Wells S, Lau YF, Lee AS. PMID: 3413063.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    90. Endocrine Genes: Analytical Methods, Experimental Approaches and Selected Systems. 1988. LAU YF.
    91. Method of genomic DNA cloning by the combination of cosmid shuttle vector and monoclonal antibody. Microbiol Immunol. 1988; 32(10):1073-8. Tagawa M, Ito T, Kanno M, Okitsu A, Sakamoto T, Imai K, Kuwabara I, Koseki H, Matsubara H, Lau YF. PMID: 3231129.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    92. Platelet glycoprotein IIb. Chromosomal localization and tissue expression. J Clin Invest. 1987 Dec; 80(6):1812-7. Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA. PMID: 3479442.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    93. The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. Mol Cell Biol. 1987 Sep; 7(9):3107-12. Boer PH, Adra CN, Lau YF, McBurney MW. PMID: 2823118.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    94. Molecular isolation and sequence determination of the cDNA for the mouse sperm-specific lactate dehydrogenase-X gene. Biochem Biophys Res Commun. 1987 Aug 14; 146(3):964-70. Wu KC, Chan K, Lee CY, Lau YF. PMID: 3619944.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    95. Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis. Gene. 1987; 57(1):53-9. Manavathu EK, Suryanarayana K, Hasnain SE, Leung M, Lau YF, Leung WC. PMID: 2828182.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    96. Male-enhanced expression and genetic conservation of a gene isolated with an anti-H-Y antibody. Trans Assoc Am Physicians. 1987; 100:45-53. Lau YF, Chan KM, Kan YW, Goldberg E. PMID: 3455075.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    97. Expression of the human apolipoprotein E gene in cultured mammalian cells. J Biol Chem. 1986 Jul 25; 261(21):9858-64. Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM. PMID: 3733697.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    98. Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mammalian cells: studies with the human growth hormone gene. Gene. 1986; 46(2-3):277-86. Choo KH, Filby G, Greco S, Lau YF, Kan YW. PMID: 3468045.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    99. Flow-sorting analysis of normal and abnormal human genomes. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:169-76. Lebo RV, Anderson LA, Lau YF, Flandermeyer R, Kan YW. PMID: 3472713.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    100. Cloning and expression of the human apolipoprotein E gene. Methods Enzymol. 1986; 128:811-23. Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM. PMID: 3014273.
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    101. Identification of a case of Y:18 translocation using a Y-specific repetitive DNA probe. Hum Genet. 1985; 69(2):102-5. Lau YF, Ying KL, Donnell GN. PMID: 2982722.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    102. A male-specific DNA probe detects heterochromatin sequences in a familial Yq- chromosome. Am J Hum Genet. 1984 Nov; 36(6):1394-6. Lau YF, Schonberg S. PMID: 6517059.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    103. Amplification and expression of human alpha-globin genes in Chinese hamster ovary cells. Mol Cell Biol. 1984 Aug; 4(8):1469-75. Lau YF, Lin CC, Kan YW. PMID: 6493227.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    104. A rapid screening test for antenatal sex determination. Lancet. 1984 Jan 07; 1(8367):14-6. Lau YF, Huang JC, Dozy AM, Kan YW. PMID: 6140342.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    105. Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):414-8. Lau YF, Kan YW. PMID: 6320187.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    106. Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster. Proc Natl Acad Sci U S A. 1983 Sep; 80(17):5225-9. Lau YF, Kan YW. PMID: 6310566.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    107. Amplification of the human alpha-globin gene enhances its expression. Trans Assoc Am Physicians. 1983; 96:93-102. Lau YF, Lin CC, Kan YW. PMID: 6679967.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    108. Studies of mammalian chromosome replication. II. Evidence for the existence of defined chromosome replicating units. Chromosoma. 1981; 83(5):721-41. Lau YF, Arrighi FE. PMID: 7028418.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    109. Cell cycle analysis and drug inhibition studies of silver staining in synchronous HeLa cells. Exp Cell Res. 1980 Sep; 129(1):139-47. Hubbell HR, Lau YF, Brown RL, Hsu TC. PMID: 6159216.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    110. Studies of mammalian chromosome replication. I. BrdU-induced differential staining patterns in interphase and metaphase chromosomes. Cytogenet Cell Genet. 1980; 27(2-3):176-83. Lau YF, Arrighi FE. PMID: 6156800.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    111. Nucleolar activity in differentiated cells after stimulation. Cytogenet Cell Genet. 1980; 26(2-4):244-50. Arrighi FE, Lau YF, Spallone A. PMID: 6156056.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    112. Cytological analyses of 14p+ variant by means of N-banding and combinations of silver staining and chromosome bandings. Hum Genet. 1979 Jan 19; 46(1):75-82. Lau YF, Wertelecki W, Pfeiffer RA, Arrighi FE. PMID: 85597.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    113. Combination of silver and fluorescent staining for metaphase chromosomes. Am J Hum Genet. 1978 Jan; 30(1):76-9. Lau YF, Pfeiffer RA, Arrighi FE, Hsu TC. PMID: 74950.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    114. Induction of premature chromosome condensation in CHO cells fused with polyethylene glycol. Exp Cell Res. 1977 Nov; 110(1):57-61. Lau YF, Brown RL, Arrighi FE. PMID: 923665.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    115. Studies of the squirel monkey, Saimiri sciureus, genome. II. C-band characterization and DNA replication patterns. Cytogenet Cell Genet. 1977; 19(1):14-25. Lau YF, Arrighi FE, Chuang CR. PMID: 408102.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    116. Variable modes of Robertsonian fusions. Cytogenet Cell Genet. 1977; 19(4):231-5. Lau YF, Hsu TC. PMID: 74307.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    117. Studies of the squirrel monkey, Saimiri sciureus, genome. I. Cytological characterization of chromosomal heterozygosity. Cytogenet Cell Genet. 1976; 17(1):51-60. Lau YF, Arrighi FE. PMID: 820523.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    118. Sister chromatid differential staining pattern in prematurely condensed chromosomes. Experientia. 1976; 32(7):917-9. Lau YF, Hittelman WN, Arrighi FE. PMID: 954984.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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