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Chris Lau, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-379-5526
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    Collapse Biography 
    Collapse Education and Training
    HARPUR COLLEGE-SUNY, BINGHAMTONB.A.06/1973CHEMISTRY
    MD ANDERSON CANCER CENTER-UTHEALTH, HOUSTONM.S.06/1976CELL BIOLOGY
    MD ANDERSON CANCER CENTER-UTHEALTH, HOUSTONPH.D.06/1979GENETICS

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Research Career Scientist Award
    Department of Veterans Affairs 1IK6BX004854Oct 1, 2019 - Sep 30, 2024
    Role: Principal Investigator
    Molecular Mechanisms of a Male-Specific Positive Feedback Loop in Liver Cancer
    Department of Veterans Affairs 1IO1BX004446Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Role Description: The project studies the synergistic actions of the male-specific oncogene TSPY and the male sex hormone receptor and its constitutively active variants in oncogenesis and disease progression in hepatocellular carcinoma, and their contributions to male biases in liver cancer.
    The Genetic Basis of Sex Differences in Liver Cancer
    Department of Defense W81XWH-16-1-0488Aug 15, 2016 - Aug 14, 2019
    Role: Principal Investigator
    Role of genetic biomarkers in clinical assessment of prostate cancer
    VA IP1BX001604Oct 1, 2012 - Sep 30, 2016
    Role: Co-Investigator, Principal Investigator-Project 3
    Role of the Y-Located TSPY Gene in Human Oncogenesis
    NIH I01BX000865Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    Sex Chromosomes and Gender Disparity in HBV-Related Hepatocellular Carcinoma
    NIH R21CA152589Jul 23, 2010 - Jun 30, 2014
    Role: Principal Investigator
    Sex Chromosomes and Gender Disparity in HBV-Related Heaptocellular Carcinoma
    NIH R21CA152589Jul 1, 2010 - Jun 30, 2013
    Role: Principal Investigator
    Y Chromosome Regulation of Autism Susceptibility Genes
    Department of Defense Autism Research Program W81XWH-08-2-0070Jun 1, 2008 - May 31, 2010
    Role: PRINCIPAL INVESTIGATOR
    The Role of the Y-Located TSPY Gene in Prostatic Oncogenesis
    VA Merit GrantApr 1, 2006 - Sep 30, 2010
    Role: Principal Investigator
    Mitochondrial Structure and Reactive Oxygen Species in Mammary Oncogneesis
    Department of Defense Breast Cancer Research Program DAMD17-03-0247Apr 3, 2003 - Mar 31, 2006
    Role: PRINCIPAL INVESTIGATOR
    The Role of the Y-Located TSPY Gene in Prostatic Oncogenesis
    Department of Defense Prostate Cancer Research Program DAMD17-03-0081Feb 1, 2003 - Jan 31, 2006
    Role: PRINCIPAL INVESTIGATOR
    FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    NIH R01HD038117Jun 1, 2000 - Feb 28, 2007
    Role: Principal Investigator
    Roles of the Y Chromosome Genes in Prostate Cancer
    Department of Defense Prostate Cancer Research Program DAMD17-00-1-0039Jan 15, 2000 - Jan 14, 2004
    Role: PRINCIPAL INVESTIGATOR
    Molecular Genetics of Male Hypertension
    VA Merit GrantOct 1, 1998 - Sep 30, 2001
    Role: PRINCIPAL INVESTIGATOR
    INTERNATIONAL WORKSHOP ON HUMAN Y CHROMOSOME
    NIH R13HD035762Apr 1, 1997 - Mar 31, 1998
    Role: Principal Investigator
    RESEARCH CAREER SCIENTIST AWARD
    VA RESEARCH CAREER SCIENTISTApr 1, 1994 - Sep 30, 2019
    Role: PRINCIPAL INVESTIGATOR
    Molecular Biology of Myocardial Ischemia
    VA Merit GrantApr 1, 1994 - Mar 31, 1997
    Role: PRINCIPAL INVESTIGATOR
    INTERNATIONAL WORKSHOPS ON HUMAN Y CHROMOSOME
    NIH R13HG001065Apr 1, 1994 - Dec 31, 1996
    Role: Principal Investigator
    U.S.-Argentina Cooperative Science Program: Characterizationof Genes Involved in Sex Determination and Sex Reversal in Akodon (Cricetidae) Rodents
    NSF INT-9202155Aug 1, 1992 - Jul 31, 1995
    Role: Principal Investigator
    FUNCTIONS OF THE TESTIS DETERMINING GENES
    NIH R01HD027392Sep 1, 1990 - Apr 30, 1999
    Role: Principal Investigator
    Functions of Zinc Finger Genes on Sex Chromosomes
    NIH 1RO1HD27392Sep 1, 1990 - Aug 31, 1994
    Role: Principal Investigator
    MOLECULAR BIOLOGY OF THE MALE ENHANCED ANTIGEN GENES
    NIH R01HD024384May 1, 1988 - Apr 30, 1994
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Lau YC, Heidemann PH, Strowitzki T. Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY. Hum Reprod. 2019 Apr 01; 34(4):770-779. PMID: 30753444.
      View in: PubMed
    2. Kido T, Lau YC. The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression. Cell Biosci. 2019; 9:22. PMID: 30867900.
      View in: PubMed
    3. Kido T, Li Y, Tanaka Y, Dahiya R, Chris Lau YF. The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner. Oncotarget. 2019 Feb 19; 10(15):1491-1506. PMID: 30863497.
      View in: PubMed
    4. Lau YC, Li Y, Kido T. Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis. Asian J Androl. 2018 Jun 29. PMID: 29974883.
      View in: PubMed
    5. Kido T, Sun Z, Lau YC. Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice. Sci Rep. 2017 06 23; 7(1):4113. PMID: 28646221.
      View in: PubMed
    6. Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC. The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants. Hum Mol Genet. 2017 03 01; 26(5):901-912. PMID: 28169398.
      View in: PubMed
    7. Kido T, Lau YC. Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers. J Genet Genomics. 2016 10 20; 43(10):577-585. PMID: 27771326.
      View in: PubMed
    8. Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, Saini S, Deng G, Gill A, Wong DK, Shiina H, Nonomura N, Lau YF, Dahiya R, Tanaka Y. Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells. Oncotarget. 2015 Jun 30; 6(18):16341-51. PMID: 26036629; PMCID: PMC4599273.
    9. Kido T, Lau YF. Roles of the Y chromosome genes in human cancers. Asian J Androl. 2015 May-Jun; 17(3):373-80. PMID: 25814157; PMCID: PMC4430935.
    10. Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau YF. SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. Hum Mol Genet. 2015 Feb 01; 24(3):685-97. PMID: 25267720.
      View in: PubMed
    11. Li Y, Zheng M, Lau YF. The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation. Cell Rep. 2014 Aug 07; 8(3):723-33. PMID: 25088423.
      View in: PubMed
    12. Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. Hum Pathol. 2014 Sep; 45(9):1847-58. PMID: 25017435.
      View in: PubMed
    13. Kido T, Lau YF. The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. Biochem Biophys Res Commun. 2014 Mar 28; 446(1):206-11. PMID: 24583132.
      View in: PubMed
    14. Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF. Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer. Cell Biosci. 2014 Feb 17; 4(1):9. PMID: 24528896.
      View in: PubMed
    15. Zheng M, Li Y, Lau YF. Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies. Methods Mol Biol. 2013; 1067:185-202. PMID: 23975793.
      View in: PubMed
    16. Li Y, Taketo T, Lau YF. Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. Methods Mol Biol. 2012; 825:3-16. PMID: 22144232.
      View in: PubMed
    17. Kido T, Ou JH, Lau YF. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PLoS One. 2011; 6(7):e22979. PMID: 21829568; PMCID: PMC3146538.
    18. Kido T, Schubert S, Schmidtke J, Chris Lau YF. Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions. J Genet Genomics. 2011 May 20; 38(5):181-91. PMID: 21621739.
      View in: PubMed
    19. Lau YF, Li Y, Kido T. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Syst Biol Reprod Med. 2011 Feb; 57(1-2):27-34. PMID: 21204751.
      View in: PubMed
    20. Kido T, Hatakeyama S, Ohyama C, Lau YF. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. Genes (Basel). 2010 Sep 14; 1(2):283-93. PMID: 24710046.
      View in: PubMed
    21. Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics. 2010 Feb 15; 26(4):585-6. PMID: 20028690.
      View in: PubMed
    22. Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. J Biol Chem. 2009 Dec 18; 284(51):35670-80. PMID: 19850934; PMCID: PMC2790998.
    23. Wu JB, Chen K, Li Y, Lau YF, Shih JC. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J. 2009 Nov; 23(11):4029-38. PMID: 19661285; PMCID: PMC2775015.
    24. Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau YF, Chan WY. Developmental staging of male murine embryonic gonad by SAGE analysis. J Genet Genomics. 2009 Apr; 36(4):215-27. PMID: 19376482.
      View in: PubMed
    25. Lau YF, Li Y. The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling. J Genet Genomics. 2009 Apr; 36(4):193-202. PMID: 19376480.
      View in: PubMed
    26. Lau YF, Li Y, Kido T. Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth Defects Res C Embryo Today. 2009 Mar; 87(1):114-22. PMID: 19306348.
      View in: PubMed
    27. Li Y, Kido T, Luo J, Fukuda M, Dobrinski I, Lau YF. Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours. Int J Exp Pathol. 2008 Oct; 89(5):342-9. PMID: 18808526.
      View in: PubMed
    28. Kido T, Lau YF. The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein. Int J Cancer. 2008 Oct 01; 123(7):1573-85. PMID: 18649364.
      View in: PubMed
    29. Li Y, Lau YF. TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities. Oncogene. 2008 Oct 16; 27(47):6141-50. PMID: 18591933.
      View in: PubMed
    30. Oh HJ, Kido T, Lau YF. PIAS1 interacts with and represses SOX9 transactivation activity. Mol Reprod Dev. 2007 Nov; 74(11):1446-55. PMID: 17440973.
      View in: PubMed
    31. de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau YF, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. JKT-1 is not a human seminoma cell line. Int J Androl. 2007 Aug; 30(4):350-65. PMID: 17705808.
      View in: PubMed
    32. Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH. Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. Clin Endocrinol (Oxf). 2007 Aug; 67(2):184-92. PMID: 17547684.
      View in: PubMed
    33. LAU YFC CHAN WY.Y Chromosome and Male Germ Cell Biology in Health and Diseases. 2007.
    34. Li Y, Tabatabai ZL, Lee TL, Hatakeyama S, Ohyama C, Chan WY, Looijenga LH, Lau YF. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. Hum Pathol. 2007 Oct; 38(10):1470-81. PMID: 17521702.
      View in: PubMed
    35. Li Y, Vilain E, Conte F, Rajpert-De Meyts E, Lau YF. Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ. Urol Oncol. 2007 Mar-Apr; 25(2):141-6. PMID: 17349529.
      View in: PubMed
    36. Kido T, Lau YF. The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones. Biochem Biophys Res Commun. 2006 Nov 10; 350(1):56-67. PMID: 16996029.
      View in: PubMed
    37. Li Y, Oh HJ, Lau YF. The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. Mol Cell Endocrinol. 2006 Sep 26; 257-258:35-46. PMID: 16904257.
      View in: PubMed
    38. Oram SW, Liu XX, Lee TL, Chan WY, Lau YF. TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC Cancer. 2006 Jun 09; 6:154. PMID: 16762081.
      View in: PubMed
    39. Vong QP, Li Y, Lau YF, Dym M, Rennert OM, Chan WY. Structural characterization and expression studies of Dby and its homologs in the mouse. J Androl. 2006 Sep-Oct; 27(5):653-61. PMID: 16728723.
      View in: PubMed
    40. Hoei-Hansen CE, Sehested A, Juhler M, Lau YF, Skakkebaek NE, Laursen H, Rajpert-de Meyts E. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J Pathol. 2006 May; 209(1):25-33. PMID: 16456896.
      View in: PubMed
    41. Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau YF, Looijenga LH, Oosterhuis JW. Germ cell lineage differentiation in non-seminomatous germ cell tumours. J Pathol. 2006 Feb; 208(3):395-400. PMID: 16273510.
      View in: PubMed
    42. Oh HJ, Lau YF. KRAB: a partner for SRY action on chromatin. Mol Cell Endocrinol. 2006 Mar 09; 247(1-2):47-52. PMID: 16414182.
      View in: PubMed
    43. Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau YF, Drop SL, Looijenga LH. Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum Pathol. 2006 Jan; 37(1):101-11. PMID: 16360422.
      View in: PubMed
    44. Kido T, Lau YF. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis. 2005 Aug; 42(4):263-75. PMID: 16035036.
      View in: PubMed
    45. Taketo T, Lee CH, Zhang J, Li Y, Lee CY, Lau YF. Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Dev Dyn. 2005 Jun; 233(2):612-22. PMID: 15789443.
      View in: PubMed
    46. Williams K, Fernandez S, Stien X, Ishii K, Love HD, Lau YF, Roberts RL, Hayward SW. Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. Prostate. 2005 Jun 01; 63(4):369-84. PMID: 15937962.
      View in: PubMed
    47. Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau YF, Oosterhuis JW, Looijenga LH. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum Pathol. 2005 May; 36(5):512-21. PMID: 15948118.
      View in: PubMed
    48. Oh HJ, Li Y, Lau YF. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod. 2005 Feb; 72(2):407-15. PMID: 15469996.
      View in: PubMed
    49. Li Y, Yue L, Taketo T, Lau YF. Protein transduction as a strategy for evaluating important factors in mammalian sex determination and differentiation. Cytogenet Genome Res. 2003; 101(3-4):237-41. PMID: 14684989.
      View in: PubMed
    50. Lau YF, Lau HW, Kömüves LG. Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer. Cytogenet Genome Res. 2003; 101(3-4):250-60. PMID: 14684991.
      View in: PubMed
    51. Liu WS, Nordqvist K, Lau YF, Fredga K. Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal. J Exp Zool. 2001 Nov 01; 290(6):551-7. PMID: 11748603.
      View in: PubMed
    52. Xian M, Zhang J, Lau YF. Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals. J Exp Zool. 2001 Nov 01; 290(6):632-41. PMID: 11748612.
      View in: PubMed
    53. Kren V, Qi N, Krenova D, Zidek V, Sladká M, Jáchymová M, Míková B, Horky K, Bonne A, Van Lith HA, Van Zutphen BF, Lau YF, Pravenec M, St Lezin E. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. Hypertension. 2001 Apr; 37(4):1147-52. PMID: 11304517.
      View in: PubMed
    54. Karliner JS, Honbo N, Epstein CJ, Xian M, Lau YF, Gray MO. Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase. J Mol Cell Cardiol. 2000 Oct; 32(10):1779-86. PMID: 11013122.
      View in: PubMed
    55. Lau YF, Zhang J. Expression analysis of thirty one Y chromosome genes in human prostate cancer. Mol Carcinog. 2000 Apr; 27(4):308-21. PMID: 10747295.
      View in: PubMed
    56. Xian M, Honbo N, Zhang J, Liew CC, Karliner JS, Lau YF. The green fluorescent protein is an efficient biological marker for cardiac myocytes. J Mol Cell Cardiol. 1999 Dec; 31(12):2155-65. PMID: 10640443.
      View in: PubMed
    57. Zhang J, Coward P, Xian M, Lau YF. In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Int J Dev Biol. 1999 May; 43(3):219-27. PMID: 10410901.
      View in: PubMed
    58. Lau YF. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. Am J Hum Genet. 1999 Apr; 64(4):921-7. PMID: 10090875; PMCID: PMC1377814.
    59. Diatchenko L, Lukyanov S, Lau YF, Siebert PD. Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes. Methods Enzymol. 1999; 303:349-80. PMID: 10349654.
      View in: PubMed
    60. Lau YF, Zhang J. Sry interactive proteins: implication for the mechanisms of sex determination. Cytogenet Cell Genet. 1998; 80(1-4):128-32. PMID: 9678346.
      View in: PubMed
    61. Shimamura R, Fraizer GC, Trapman J, Saunders GF. The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor. Clin Cancer Res. 1997 Dec; 3(12 Pt 2):2571-80. PMID: 9815658.
      View in: PubMed
    62. Liou JD, Ma YY, Gibson LH, Su H, Charest N, Lau YF, Yang-Feng TL. Cytogenetic and molecular studies of a familial paracentric inversion of Y chromosome present in a patient with ambiguous genitalia. Am J Med Genet. 1997 May 16; 70(2):134-7. PMID: 9128931.
      View in: PubMed
    63. Vogt PH, Affara N, Davey P, Hammer M, Jobling MA, Lau YF, Mitchell M, Schempp W, Tyler-Smith C, Williams G, Yen P, Rappold GA. Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. Cytogenet Cell Genet. 1997; 79(1-2):1-20. PMID: 9533010.
      View in: PubMed
    64. Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6025-30. PMID: 8650213; PMCID: PMC39182.
    65. Affara N, Bishop C, Brown W, Cooke H, Davey P, Ellis N, Graves JM, Jones M, Mitchell M, Rappold G, Tyler-Smith C, Yen P, Lau YF. Report of the Second International Workshop on Y Chromosome Mapping 1995. Cytogenet Cell Genet. 1996; 73(1-2):33-76. PMID: 8646888.
      View in: PubMed
    66. Dubin RA, Coward P, Lau YF, Ostrer H. Functional comparison of the Mus musculus molossinus and Mus musculus domesticus Sry genes. Mol Endocrinol. 1995 Dec; 9(12):1645-54. PMID: 8614401.
      View in: PubMed
    67. Coward P, Nagai K, Chen D, Thomas HD, Nagamine CM, Lau YF. Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal. Nat Genet. 1994 Mar; 6(3):245-50. PMID: 8012385.
      View in: PubMed
    68. Affara NA, Lau YF, Briggs H, Davey P, Jones MH, Khwaja O, Mitchell M, Sargent C. Report and abstracts of the First International Workshop on Y Chromosome Mapping 1994. Cambridge, England, April 2-5, 1994. Cytogenet Cell Genet. 1994; 67(4):359-402. PMID: 7924456.
      View in: PubMed
    69. Boissonneault G, Lau YF. A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids. Mol Cell Biol. 1993 Jul; 13(7):4323-30. PMID: 8321234; PMCID: PMC359989.
    70. Su H, Lau YF. Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach. Am J Hum Genet. 1993 Jan; 52(1):24-38. PMID: 8434602; PMCID: PMC1682107.
    71. Zhang JS, Yang-Feng TL, Muller U, Mohandas TK, de Jong PJ, Lau YF. Molecular isolation and characterization of an expressed gene from the human Y chromosome. Hum Mol Genet. 1992 Dec; 1(9):717-26. PMID: 1284595.
      View in: PubMed
    72. Su H, Lau YF. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Mol Reprod Dev. 1992 Nov; 33(3):252-8. PMID: 1449792.
      View in: PubMed
    73. Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U. Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. J Reprod Immunol. 1992 Apr; 21(3):275-91. PMID: 1522559.
      View in: PubMed
    74. Lau YF, Yang-Feng TL, Elder B, Fredga K, Wiberg UH. Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal. Cytogenet Cell Genet. 1992; 60(1):48-54. PMID: 1349859.
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    75. Nagamine CM, Nishioka Y, Moriwaki K, Boursot P, Bonhomme F, Lau YF. The musculus-type Y chromosome of the laboratory mouse is of Asian origin. Mamm Genome. 1992; 3(2):84-91. PMID: 1352158.
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    76. Liu MS, Chan KM, Lau YF, Lee CY. Molecular cloning of an acrosomal sperm antigen gene and the production of its recombinant protein for immunocontraceptive vaccine. Mol Reprod Dev. 1990 Mar; 25(3):302-8. PMID: 2331378.
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    77. Leung WY, Lindgren V, Lau YF, Yang-Feng YL. Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes. Cytogenet Cell Genet. 1990; 54(3-4):151-3. PMID: 2265557.
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    78. Nagamine CM, Chan K, Hake LE, Lau YF. The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues. Genes Dev. 1990 Jan; 4(1):63-74. PMID: 1968414.
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    79. Jen J, Deschepper CF, Shackleford GM, Lee CY, Lau YF. Stage-specific expression of the lactate dehydrogenase-X gene in adult and developing mouse testes. Mol Reprod Dev. 1990 Jan; 25(1):14-21. PMID: 2393579.
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    80. Lau YF, Chan KM. The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. Am J Hum Genet. 1989 Dec; 45(6):942-52. PMID: 2511751; PMCID: PMC1683462.
    81. Lau YF, Chan KM, Sparkes R. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8462-6. PMID: 2813404; PMCID: PMC298302.
    82. Nagamine CM, Chan K, Lau YF. A PCR artifact: generation of heteroduplexes. Am J Hum Genet. 1989 Aug; 45(2):337-9. PMID: 2631699; PMCID: PMC1683350.
    83. Poole SJ, Law ML, Kao FT, Lau YF. Isolation and chromosomal localization of the human En-2 gene. Genomics. 1989 Apr; 4(3):225-31. PMID: 2565873.
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    84. Nagamine CM, Chan KM, Kozak CA, Lau YF. Chromosome mapping and expression of a putative testis-determining gene in mouse. Science. 1989 Jan 06; 243(4887):80-3. PMID: 2563174.
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    85. Gross MS, Sefiani A, de Tand MF, Lau YF, Saidi-Mehtar N, Hors-Cayla MC, Frezal J, Van Cong N. The anonymous PAS45 probe detects RFLPs in 13q31. Ann Genet. 1989; 32(2):73-7. PMID: 2569289.
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    86. Kao FT, Wu KC, Law ML, Hartz JA, Lau YF. Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5. Somat Cell Mol Genet. 1988 Sep; 14(5):515-8. PMID: 3175768.
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    87. Kim YK, Wells S, Lau YF, Lee AS. Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):5894-8. PMID: 3413063; PMCID: PMC281871.
    88. LAU YF.Endocrine Genes: Analytical Methods, Experimental Approaches and Selected Systems. 1988.
    89. Tagawa M, Ito T, Kanno M, Okitsu A, Sakamoto T, Imai K, Kuwabara I, Koseki H, Matsubara H, Lau YF. Method of genomic DNA cloning by the combination of cosmid shuttle vector and monoclonal antibody. Microbiol Immunol. 1988; 32(10):1073-8. PMID: 3231129.
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    90. Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA. Platelet glycoprotein IIb. Chromosomal localization and tissue expression. J Clin Invest. 1987 Dec; 80(6):1812-7. PMID: 3479442; PMCID: PMC442459.
    91. Boer PH, Adra CN, Lau YF, McBurney MW. The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. Mol Cell Biol. 1987 Sep; 7(9):3107-12. PMID: 2823118.
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    92. Wu KC, Chan K, Lee CY, Lau YF. Molecular isolation and sequence determination of the cDNA for the mouse sperm-specific lactate dehydrogenase-X gene. Biochem Biophys Res Commun. 1987 Aug 14; 146(3):964-70. PMID: 3619944.
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    93. Manavathu EK, Suryanarayana K, Hasnain SE, Leung M, Lau YF, Leung WC. Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis. Gene. 1987; 57(1):53-9. PMID: 2828182.
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    94. Lau YF, Chan KM, Kan YW, Goldberg E. Male-enhanced expression and genetic conservation of a gene isolated with an anti-H-Y antibody. Trans Assoc Am Physicians. 1987; 100:45-53. PMID: 3455075.
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    95. Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM. Expression of the human apolipoprotein E gene in cultured mammalian cells. J Biol Chem. 1986 Jul 25; 261(21):9858-64. PMID: 3733697.
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    96. Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM. Cloning and expression of the human apolipoprotein E gene. Methods Enzymol. 1986; 128:811-23. PMID: 3014273.
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    97. Lebo RV, Anderson LA, Lau YF, Flandermeyer R, Kan YW. Flow-sorting analysis of normal and abnormal human genomes. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:169-76. PMID: 3472713.
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    98. Choo KH, Filby G, Greco S, Lau YF, Kan YW. Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mammalian cells: studies with the human growth hormone gene. Gene. 1986; 46(2-3):277-86. PMID: 3468045.
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    99. Lau YF, Ying KL, Donnell GN. Identification of a case of Y:18 translocation using a Y-specific repetitive DNA probe. Hum Genet. 1985; 69(2):102-5. PMID: 2982722.
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    100. Lau YF, Schonberg S. A male-specific DNA probe detects heterochromatin sequences in a familial Yq- chromosome. Am J Hum Genet. 1984 Nov; 36(6):1394-6. PMID: 6517059.
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    101. Lau YF, Lin CC, Kan YW. Amplification and expression of human alpha-globin genes in Chinese hamster ovary cells. Mol Cell Biol. 1984 Aug; 4(8):1469-75. PMID: 6493227; PMCID: PMC368936.
    102. Lau YF, Huang JC, Dozy AM, Kan YW. A rapid screening test for antenatal sex determination. Lancet. 1984 Jan 07; 1(8367):14-6. PMID: 6140342.
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    103. Lau YF, Kan YW. Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):414-8. PMID: 6320187; PMCID: PMC344687.
    104. Lau YF, Kan YW. Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster. Proc Natl Acad Sci U S A. 1983 Sep; 80(17):5225-9. PMID: 6310566; PMCID: PMC384225.
    105. Lau YF, Lin CC, Kan YW. Amplification of the human alpha-globin gene enhances its expression. Trans Assoc Am Physicians. 1983; 96:93-102. PMID: 6679967.
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    106. Lau YF, Arrighi FE. Studies of mammalian chromosome replication. II. Evidence for the existence of defined chromosome replicating units. Chromosoma. 1981; 83(5):721-41. PMID: 7028418.
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    107. Hubbell HR, Lau YF, Brown RL, Hsu TC. Cell cycle analysis and drug inhibition studies of silver staining in synchronous HeLa cells. Exp Cell Res. 1980 Sep; 129(1):139-47. PMID: 6159216.
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    108. Lau YF, Arrighi FE. Studies of mammalian chromosome replication. I. BrdU-induced differential staining patterns in interphase and metaphase chromosomes. Cytogenet Cell Genet. 1980; 27(2-3):176-83. PMID: 6156800.
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    109. Arrighi FE, Lau YF, Spallone A. Nucleolar activity in differentiated cells after stimulation. Cytogenet Cell Genet. 1980; 26(2-4):244-50. PMID: 6156056.
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    110. Lau YF, Wertelecki W, Pfeiffer RA, Arrighi FE. Cytological analyses of 14p+ variant by means of N-banding and combinations of silver staining and chromosome bandings. Hum Genet. 1979 Jan 19; 46(1):75-82. PMID: 85597.
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    111. Lau YF, Pfeiffer RA, Arrighi FE, Hsu TC. Combination of silver and fluorescent staining for metaphase chromosomes. Am J Hum Genet. 1978 Jan; 30(1):76-9. PMID: 74950.
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    112. Lau YF, Brown RL, Arrighi FE. Induction of premature chromosome condensation in CHO cells fused with polyethylene glycol. Exp Cell Res. 1977 Nov; 110(1):57-61. PMID: 923665.
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    113. Lau YF, Arrighi FE, Chuang CR. Studies of the squirel monkey, Saimiri sciureus, genome. II. C-band characterization and DNA replication patterns. Cytogenet Cell Genet. 1977; 19(1):14-25. PMID: 408102.
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    114. Lau YF, Hsu TC. Variable modes of Robertsonian fusions. Cytogenet Cell Genet. 1977; 19(4):231-5. PMID: 74307.
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    115. Lau YF, Hittelman WN, Arrighi FE. Sister chromatid differential staining pattern in prematurely condensed chromosomes. Experientia. 1976; 32(7):917-9. PMID: 954984.
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    116. Lau YF, Arrighi FE. Studies of the squirrel monkey, Saimiri sciureus, genome. I. Cytological characterization of chromosomal heterozygosity. Cytogenet Cell Genet. 1976; 17(1):51-60. PMID: 820523.
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