Diana Alba, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address2540 23rd Street, #2701
San Francisco CA 94110
Phone415-514-9031
ORCID ORCID Icon0000-0002-1398-9861 Additional info
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    Collapse Biography 
    Collapse Education and Training
    New York Medical CollegeM.D.2010
    University of Miami/Jackson Memorial HospitalResidency2013Internal Medicine
    University of California, San FranciscoFellowshipEndocrinology, Diabetes and Metabolism
    University of California, San Francisco2021Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    Robert Wood Johnson Foundation2020Harold Amos Scholar
    American Diabetes Association 2018Minority Postdoctoral Fellowship Award
    UCSF-Bay Area Center for AIDS Research2022Early-Career Research Excellence Award in Basic/Translational Science

    Collapse Overview 
    Collapse Overview
    Diana Alba is an Assistant Professor of Medicine in the Division of Endocrinology at the University of California, San Francisco. As a physician-scientist, her research program is focused on identifying the transcriptional pathways that regulate adipose tissue function during normal development and obesity. Her work investigates how adipose tissue dysfunction, particularly through fibrotic remodeling, drives insulin resistance and metabolic dysfunction. By targeting these pathways, her lab aims to uncover novel therapeutic strategies to prevent or treat metabolic diseases through a deeper understanding of adipose tissue biology.

    Collapse Research 
    Collapse Research Activities and Funding
    Dissecting the cellular interplays of adipose tissue remodeling in the regulation of insulin sensitivity
    NIH/NIDDK 1K08DK124679
    Role: PI
    Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIV
    NIH/NIDDK 1R56DK133997
    Role: Co-Investigator
    Probing the cellular determinants of adipose tissue health versus fibrosis in the regulation of human insulin sensitivity
    Robert Wood Johnson Foundation, Harold Amos Medical Faculty Development Program
    Role: PI

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin. J Biol Chem. 2024 Feb; 300(2):105631. Datta R, Mukherjee D, Podolsky MJ, Yang CD, Alba DL, Singh S, Arnold TD, Koliwad S, Lizama CO, Atabai K. PMID: 38199575; PMCID: PMC10850974.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Effects of Pharmacotherapy for the Treatment of Obesity in an Urban, Safety-Net Population. Cureus. 2023 Oct; 15(10):e47922. Kim EK, Hills NK, Cheng Z, Tucker C, Gutierrez M, Alba D, Murphy E, Kim S. PMID: 38034269; PMCID: PMC10682737.
      View in: PubMed   Mentions:
    3. MFGE8 inhibits insulin signaling through PTP1B. bioRxiv. 2023 Jun 01. Datta R, Podolsky MJ, Yang CD, Alba DL, Singh S, Koliwad S, Lizama CO, Atabai K. PMID: 37398282; PMCID: PMC10312531.
      View in: PubMed   Mentions:
    4. Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy. Diabetes. 2023 01 01; 72(1):59-70. Mandel-Brehm C, Vazquez SE, Liverman C, Cheng M, Quandt Z, Kung AF, Parent A, Miao B, Disse E, Cugnet-Anceau C, Dalle S, Orlova E, Frolova E, Alba D, Michels A, Oftedal BE, Lionakis MS, Husebye ES, Agarwal AK, Li X, Zhu C, Li Q, Oral E, Brown R, Anderson MS, Garg A, DeRisi JL. PMID: 35709010; PMCID: PMC9797316.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    5. A gene-diet interaction controlling relative intake of dietary carbohydrates and fats. Mol Metab. 2022 04; 58:101442. Nelson NG, Wu L, Maier MT, Lam D, Cheang R, Alba D, Huang A, Neumann DA, Hill T, Vagena E, Barsh GS, Medina MW, Krauss RM, Koliwad SK, Xu AW. PMID: 35051651; PMCID: PMC9710720.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    6. Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems. Small. 2022 01; 18(3):e2103157. Qi L, Zushin PH, Chang CF, Lee YT, Alba DL, Koliwad SK, Stahl A. PMID: 34761526; PMCID: PMC8776615.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health. Elife. 2021 10 07; 10. Ang QY, Alba DL, Upadhyay V, Bisanz JE, Cai J, Lee HL, Barajas E, Wei G, Noecker C, Patterson AD, Koliwad SK, Turnbaugh PJ. PMID: 34617511; PMCID: PMC8612731.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    8. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020 08 06; 182(3):563-577.e20. Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. PMID: 32615086; PMCID: PMC7415677.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    9. Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria. Nat Microbiol. 2020 01; 5(1):56-66. Bess EN, Bisanz JE, Yarza F, Bustion A, Rich BE, Li X, Kitamura S, Waligurski E, Ang QY, Alba DL, Spanogiannopoulos P, Nayfach S, Koliwad SK, Wolan DW, Franke AA, Turnbaugh PJ. PMID: 31686027; PMCID: PMC6941677.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    10. Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. J Clin Invest. 2019 08 01; 129(11):4676-4681. Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA. PMID: 31369399; PMCID: PMC6819098.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications. J Infect Dis. 2019 07 02; 220(3):420-431. Godfrey C, Bremer A, Alba D, Apovian C, Koethe JR, Koliwad S, Lewis D, Lo J, McComsey GA, Eckard A, Srinivasa S, Trevillyan J, Palmer C, Grinspoon S. PMID: 30893434; PMCID: PMC6941618.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    12. Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status. Physiol Behav. 2019 07 01; 206:264-273. Mason AE, Jhaveri K, Schleicher S, Almeida C, Hartman A, Wackerly A, Alba D, Koliwad SK, Epel ES, Aschbacher K. PMID: 31002858; PMCID: PMC6563839.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Changes in Lean Mass, Absolute and Relative Muscle Strength, and Physical Performance After Gastric Bypass Surgery. J Clin Endocrinol Metab. 2019 03 01; 104(3):711-720. Alba DL, Wu L, Cawthon PM, Mulligan K, Lang T, Patel S, King NJ, Carter JT, Rogers SJ, Posselt AM, Stewart L, Shoback DM, Schafer AL. PMID: 30657952; PMCID: PMC6339456.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    14. Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans. J Clin Endocrinol Metab. 2018 09 01; 103(9):3194-3204. Alba DL, Farooq JA, Lin MYC, Schafer AL, Shepherd J, Koliwad SK. PMID: 29846621; PMCID: PMC6126891.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    15. Methadone-Associated Hypoglycemia in Chronic Renal Failure Masquerading as an Insulinoma. Pain Med. 2018 09 01; 19(9):1876-1878. Masharani U, Alba D. PMID: 29145621.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis. Cell Metab. 2018 01 09; 27(1):180-194.e6. Hasegawa Y, Ikeda K, Chen Y, Alba DL, Stifler D, Shinoda K, Hosono T, Maretich P, Yang Y, Ishigaki Y, Chi J, Cohen P, Koliwad SK, Kajimura S. PMID: 29320702; PMCID: PMC5765755.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    17. Developmental staging of male murine embryonic gonad by SAGE analysis. J Genet Genomics. 2009 Apr; 36(4):215-27. Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau YF, Chan WY. PMID: 19376482; PMCID: PMC3314242.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. Application of transcriptional and biological network analyses in mouse germ-cell transcriptomes. Genomics. 2006 Jul; 88(1):18-33. Lee TL, Alba D, Baxendale V, Rennert OM, Chan WY. PMID: 16678385.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    19. Transcriptome analyses of male germ cells with serial analysis of gene expression (SAGE). Mol Cell Endocrinol. 2006 May 16; 250(1-2):8-19. Chan WY, Lee TL, Wu SM, Ruszczyk L, Alba D, Baxendale V, Rennert OM. PMID: 16413108.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
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