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Robert Mahley, MD, PhD

Title(s)Professor, Pathology
SchoolSchool of Medicine
AddressGladstone Inst Neurological
1650 Owens Street
San Francisco CA 94158
Phone--
ORCID ORCID Icon0000-0003-3543-9278 Additional info
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    Collapse Overview 
    Collapse Overview
    Areas of Investigation
    The major focus of our laboratory is to elucidate the function of apolipoprotein (apo) E in both cardiovascular disease and neurobiology. We are especially interested in determining the basis of the differential effects of the apoE isoforms (apoE2, E3, and E4) in neuronal repair/remodeling, in neuroprotection, and in defining how apoE4 causes neuropathology.

    Significance
    ApoE is produced in abundance in the brain and serves as the principal lipid transport vehicle in cerebrospinal fluid. ApoE4 is a major gene associated with 60–70% of cases of sporadic and familial Alzheimer’s disease. ApoE4 increases the occurrence and lowers the age of onset of Alzheimer’s disease and is also associated with poor clinical outcome in patients with traumatic brain injury. Defining the effects of the three apoE isoforms on the structure and function of the brain is providing crucial insights into the contribution of apoE4 to neurological disease, and providing a way forward for treating Alzheimer’s disease and other apoE4-associated neurodegenerative disorders.

    Approaches
    We use biophysical techniques in combination with cell and molecular biology, and transgenic and gene knockout mice to study the molecular mechanisms involving apoE in normal development and disease, including Alzheimer’s disease and other neurodegenerative diseases. Medicinal chemistry is used to identify small molecules that modulate the structure of the apoE4.

    Contributions
    My laboratory described apoE’s receptor ligand function, determined its protein and gene sequences, mapped the amino acid residues involved in receptor binding, and defined the three-dimensional structure of the ligand-binding domain. Understanding the structure and function of apoE laid the groundwork for the recent explosion of studies concerning apoE4 and Alzheimer’s disease. My laboratory was involved in describing the role of apoE in lipid transport in the nervous system, modulation of mitochondrial activity, and cytoskeletal stability involving normal and pathological CNS metabolism. By establishing brain-specific apoE transgenic mice, we demonstrated detrimental effects on apoE4 on the central nervous system in vivo and described a mechanism whereby apoE4 is involved in neuropathology.

    Research Summary
    Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and cardiovascular disease. It has since emerged as a major risk factor (causative gene) for Alzheimer’s disease and other neurodegenerative disorders. Detailed understanding of the structural features of the three isoforms (apoE2, apoE3, and apoE4), which differ by only a single amino acid interchange, has elucidated their unique functions. ApoE2 and apoE4 increase the risk for heart disease: apoE2 increases atherogenic lipoprotein levels (it binds poorly to LDL receptors) and apoE4 increases LDL levels (it binds preferentially to triglyceride-rich, very low density lipoproteins, leading to downregulation of LDL receptors). ApoE4 also increases the risk for neurodegenerative diseases, decreases their age of onset, or alters their progression. ApoE4 likely causes neurodegeneration secondary to its abnormal structure, caused by an interaction between its carboxyl- and amino-terminal domains, called domain interaction. When neurons are stressed or injured, they synthesize apoE to redistribute cholesterol for neuronal repair or remodeling. However, because of its altered structure, neuronal apoE4 undergoes neuron-specific proteolysis, generating neurotoxic fragments (12–29-kDa) that escape the secretory pathway and cause mitochondrial dysfunction and cytoskeletal alterations, including tau phosphorylation. ApoE4-associated pathology can be prevented by small-molecule structure correctors that block domain interaction by converting apoE4 to a molecule that resembles apoE3 both structurally and functionally. Structure correctors are a potential therapeutic approach to reduce apoE4 pathology in both cardiovascular and neurological disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Proteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic Mechanisms
    NIH/NIA R01AG059751Sep 15, 2019 - May 31, 2024
    Role: Principal Investigator
    Develop GABAergic Neuron Protectors for Treating ApoE4-Related Alzheimer's Disease
    NIH/NIA R44AG063691May 1, 2019 - Oct 31, 2019
    Role: Principal Investigator
    Apolipoprotein E and Alzheimer's Disease: Mitochondrial Dysfunction and Neurodegeneration
    NIH/NIA R56AG057932Sep 30, 2018 - Aug 31, 2019
    Role: Principal Investigator
    ApoE2 and Alzheimer's Disease: Structural and Functional Roles in CNS Metabolism
    NIH/NIA R56AG056307Sep 1, 2018 - Aug 31, 2019
    Role: Principal Investigator
    Somatostatin (SST)-GABAergic Interneuron Therapy for Alzheimer's Disease with ApoE4
    NIH/NIA R44AG060873Sep 1, 2018 - Feb 28, 2019
    Role: Principal Investigator
    Targeting ApoE4 as a Therapeutic Strategy for Alzheimer's Disease
    NIH/NIA U01AG043394Sep 30, 2012 - May 31, 2017
    Role: Principal Investigator
    ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers Disease
    NIH/NIDA R03DA034595May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Role of apoE structure and metabolism in neurodegeneration
    NIH/NIA R01AG028793Mar 1, 2008 - Feb 28, 2014
    Role: Principal Investigator
    EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION
    NIH/NCRR C06RR018928Sep 15, 2003 - Sep 14, 2005
    Role: Principal Investigator
    Targeting Apolipoprotein E4-related Neuropathology
    NIH/NINDS R21NS046465Jul 1, 2003 - Jun 30, 2006
    Role: Principal Investigator
    Genetic Determinants: Low HDL, High Triglycerides, Obes*
    NIH/NHLBI R01HL071027Apr 1, 2002 - Mar 31, 2004
    Role: Principal Investigator
    GENETIC ALTERATIONS ON LIPOPROTEINS AND ATHEROSCLEROSIS
    NIH/NHLBI P01HL047660Sep 30, 1992 - Sep 29, 1997
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH/NHLBI S15HL049381Sep 1, 1992 - Aug 31, 1993
    Role: Principal Investigator
    LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM
    NIH/NHLBI P01HL041633Feb 1, 1989 - Jan 31, 2005
    Role: Co-Principal Investigator
    NHLBI SHARED RESEARCH FACILITY FOR MOLECULAR BIOLOGY
    NIH/NHLBI C06HL039962Sep 30, 1987 - Sep 29, 1993
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT GRANT
    NIH/NCRR S07RR005880Apr 1, 1983 - Sep 29, 1992
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function. J Alzheimers Dis. 2019; 68(3):991-1011. Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW. PMID: 30883359.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    2. Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases. Clin Chem. 2017 01; 63(1):14-20. Mahley RW. PMID: 28062606.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    3. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016 Oct 13; 538(7624):201-206. Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D. PMID: 27654912.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimals
    4. Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders. J Mol Med (Berl). 2016 07; 94(7):739-46. Mahley RW. PMID: 27277824.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    5. Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism. Arterioscler Thromb Vasc Biol. 2016 07; 36(7):1305-15. Mahley RW. PMID: 27174096.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    6. Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature. 2014 Sep 18; 513(7518):409-13. Lazaridis I, Patterson N, Mittnik A, Renaud G, Mallick S, Kirsanow K, Sudmant PH, Schraiber JG, Castellano S, Lipson M, Berger B, Economou C, Bollongino R, Fu Q, Bos KI, Nordenfelt S, Li H, de Filippo C, Prüfer K, Sawyer S, Posth C, Haak W, Hallgren F, Fornander E, Rohland N, Delsate D, Francken M, Guinet JM, Wahl J, Ayodo G, Babiker HA, Bailliet G, Balanovska E, Balanovsky O, Barrantes R, Bedoya G, Ben-Ami H, Bene J, Berrada F, Bravi CM, Brisighelli F, Busby GB, Cali F, Churnosov M, Cole DE, Corach D, Damba L, van Driem G, Dryomov S, Dugoujon JM, Fedorova SA, Gallego Romero I, Gubina M, Hammer M, Henn BM, Hervig T, Hodoglugil U, Jha AR, Karachanak-Yankova S, Khusainova R, Khusnutdinova E, Kittles R, Kivisild T, Klitz W, Kucinskas V, Kushniarevich A, Laredj L, Litvinov S, Loukidis T, Mahley RW, Melegh B, Metspalu E, Molina J, Mountain J, Näkkäläjärvi K, Nesheva D, Nyambo T, Osipova L, Parik J, Platonov F, Posukh O, Romano V, Rothhammer F, Rudan I, Ruizbakiev R, Sahakyan H, Sajantila A, Salas A, Starikovskaya EB, Tarekegn A, Toncheva D, Turdikulova S, Uktveryte I, Utevska O, Vasquez R, Villena M, Voevoda M, Winkler CA, Yepiskoposyan L, Zalloua P, Zemunik T, Cooper A, Capelli C, Thomas MG, Ruiz-Linares A, Tishkoff SA, Singh L, Thangaraj K, Villems R, Comas D, Sukernik R, Metspalu M, Meyer M, Eichler EE, Burger J, Slatkin M, Pääbo S, Kelso J, Reich D, Krause J. PMID: 25230663.
      View in: PubMed   Mentions: 278     Fields:    Translation:Humans
    7. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiol Dis. 2014 Dec; 72 Pt A:3-12. Huang Y, Mahley RW. PMID: 25173806.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    8. Shinya Yamanaka, M.D., Ph.D. - 2012 Nobel Prize Laureate: how his dream of a research career provides vision for the next generation of young scientists. Anadolu Kardiyol Derg. 2013 May; 13(3):204-6. Mahley RW. PMID: 23618992.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron. 2012 Dec 06; 76(5):871-85. Mahley RW, Huang Y. PMID: 23217737.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    10. Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology. J Med Chem. 2012 Nov 08; 55(21):8997-9008. Mahley RW, Huang Y. PMID: 23013167.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    11. Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit. Alzheimers Dement. 2012 Sep; 8(5):445-52. Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, Feinberg LF, Frisoni G, Green C, Guimaraes RM, Gwyther LP, Hefti FF, Hutton M, Kawas C, Kent DM, Kuller L, Langa KM, Mahley RW, Maslow K, Masters CL, Meier DE, Neumann PJ, Paul SM, Petersen RC, Sager MA, Sano M, Schenk D, Soares H, Sperling RA, Stahl SM, van Deerlin V, Stern Y, Weir D, Wolk DA, Trojanowski JQ. PMID: 22959699.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    12. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012; 8(3):e1002607. Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh HW, Wu Y, Bidulescu A, Rasmussen-Torvik LJ, Greenwood CM, Ladouceur M, Grimsby J, Manning AK, Liu CT, Kooner J, Mooser VE, Vollenweider P, Kapur KA, Chambers J, Wareham NJ, Langenberg C, Frants R, Willems-Vandijk K, Oostra BA, Willems SM, Lamina C, Winkler TW, Psaty BM, Tracy RP, Brody J, Chen I, Viikari J, Kähönen M, Pramstaller PP, Evans DM, St Pourcain B, Sattar N, Wood AR, Bandinelli S, Carlson OD, Egan JM, Böhringer S, van Heemst D, Kedenko L, Kristiansson K, Nuotio ML, Loo BM, Harris T, Garcia M, Kanaya A, Haun M, Klopp N, Wichmann HE, Deloukas P, Katsareli E, Couper DJ, Duncan BB, Kloppenburg M, Adair LS, Borja JB, Wilson JG, Musani S, Guo X, Johnson T, Semple R, Teslovich TM, Allison MA, Redline S, Buxbaum SG, Mohlke KL, Meulenbelt I, Ballantyne CM, Dedoussis GV, Hu FB, Liu Y, Paulweber B, Spector TD, Slagboom PE, Ferrucci L, Jula A, Perola M, Raitakari O, Florez JC, Salomaa V, Eriksson JG, Frayling TM, Hicks AA, Lehtimäki T, Smith GD, Siscovick DS, Kronenberg F, van Duijn C, Loos RJ, Waterworth DM, Meigs JB, Dupuis J, Richards JB, Voight BF, Scott LJ, Steinthorsdottir V, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Hofmann OM, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Boström KB, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Morris AD, Palmer CN, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Pedersen O, Barroso I, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Soranzo N, Wheeler E, Glazer NL, Bouatia-Naji N, Mägi R, Randall J, Elliott P, Rybin D, Dehghan A, Hottenga JJ, Song K, Goel A, Lajunen T, Doney A, Cavalcanti-Proença C, Kumari M, Timpson NJ, Zabena C, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Roccasecca RM, Pattou F, Sethupathy P, Ariyurek Y, Barter P, Beilby JP, Ben-Shlomo Y, Bergmann S, Bochud M, Bonnefond A, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Crisponi L, Day IN, de Geus EJ, Delplanque J, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Grundy S, Gwilliam R, Hallmans G, Hammond N, Han X, Hartikainen AL, Hayward C, Heath SC, Hercberg S, Hillman DR, Hingorani AD, Hui J, Hung J, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Mahley R, Mangino M, Martínez-Larrad MT, McAteer JB, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Mukherjee S, Naitza S, et al. PMID: 22479202.
      View in: PubMed   Mentions: 181     Fields:    Translation:Humans
    13. Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations. Ann Hum Genet. 2012 Mar; 76(2):128-41. Hodoglugil U, Mahley RW. PMID: 22332727.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    14. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One. 2012; 7(1):e29202. Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D, Adeyemo A, Rotimi CN, Ng MC, Langefeld CD, Freedman BI, Bowden DW, Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Boström KB, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Soranzo N, Wheeler E, Glazer NL, Bouatia-Naji N, Mägi R, Randall J, Johnson T, Elliott P, Rybin D, Henneman P, Dehghan A, Hottenga JJ, Song K, Goel A, Egan JM, Lajunen T, Doney A, Kanoni S, Cavalcanti-Proença C, Kumari M, Timpson NJ, Zabena C, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Roccasecca RM, Pattou F, Sethupathy P, Ariyurek Y, Barter P, Beilby JP, Ben-Shlomo Y, Bergmann S, Bochud M, Bonnefond A, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Crisponi L, Day IN, de Geus EJ, Delplanque J, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Grundy S, Gwilliam R, Hallmans G, Hammond N, Han X, Hartikainen AL, Hayward C, Heath SC, Hercberg S, Hicks AA, Hillman DR, Hingorani AD, Hui J, Hung J, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Mukherjee S, Naitza S, Neville MJ, Oostra BA, Orrù M, Pakyz R, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Seedorf U, Sharp SJ, Shields B, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Tönjes A, Uitterlinden AG, van Dijk KW, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Ward KL, Watkins H, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, Borecki IB, Loos RJ, Meneton P, Magnusson PK, Nathan DM, Williams GH, Silander K, et al. PMID: 22238593.
      View in: PubMed   Mentions: 76     Fields:    Translation:Humans
    15. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17; 287(8):5253-66. Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. PMID: 22158868.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    16. Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks. Ann Hum Genet. 2011 May; 75(3):398-417. Hodoglugil U, Williamson DW, Yu Y, Farrer LA, Mahley RW. PMID: 21488854.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13; 286(19):17217-26. Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. PMID: 21454574.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    18. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem. 2011 Feb 18; 286(7):5215-21. Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. PMID: 21118811.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
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    147. Chylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptake. J Biol Chem. 1989 Jun 05; 264(16):9571-82. Hussain MM, Mahley RW, Boyles JK, Fainaru M, Brecht WJ, Lindquist PA. PMID: 2722852.
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    148. Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits. J Clin Invest. 1989 Jun; 83(6):2125-30. Mahley RW, Weisgraber KH, Hussain MM, Greenman B, Fisher M, Vogel T, Gorecki M. PMID: 2723074.
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    151. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest. 1989 Mar; 83(3):1015-31. Boyles JK, Zoellner CD, Anderson LJ, Kosik LM, Pitas RE, Weisgraber KH, Hui DY, Mahley RW, Gebicke-Haerter PJ, Ignatius MJ. PMID: 2493483.
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    153. Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes. Arteriosclerosis. 1989 Jan-Feb; 9(1):50-7. Weisgraber KH, Newhouse YM, Taylor JM, Tuan B, Nestruck AC, Davignon J, Mahley RW. PMID: 2912421.
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    154. Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes. Biochem Biophys Res Commun. 1988 Dec 30; 157(3):1212-7. Weisgraber KH, Newhouse YM, Mahley RW. PMID: 3207421.
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    155. Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9758-62. Weisgraber KH, Innerarity TL, Newhouse YM, Young SG, Arnold KS, Krauss RM, Vega GL, Grundy SM, Mahley RW. PMID: 3200853.
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    156. Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state. J Cell Biol. 1988 Sep; 107(3):1207-13. Majack RA, Castle CK, Goodman LV, Weisgraber KH, Mahley RW, Shooter EM, Gebicke-Haerter PJ. PMID: 2458361.
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    157. Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. J Mol Biol. 1988 Jul 05; 202(1):179-81. Aggerbeck LP, Wetterau JR, Weisgraber KH, Mahley RW, Agard DA. PMID: 3172212.
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    158. Apolipoprotein E-binding proteins isolated from dog and human liver. Arteriosclerosis. 1988 May-Jun; 8(3):288-97. Beisiegel U, Weber W, Havinga JR, Ihrke G, Hui DY, Wernette-Hammond ME, Turck CW, Innerarity TL, Mahley RW. PMID: 2835955.
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    159. Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors. J Clin Invest. 1988 May; 81(5):1332-40. Koo C, Wernette-Hammond ME, Garcia Z, Malloy MJ, Uauy R, East C, Bilheimer DW, Mahley RW, Innerarity TL. PMID: 3163347.
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    160. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988 Apr 29; 240(4852):622-30. Mahley RW. PMID: 3283935.
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    161. Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions. J Biol Chem. 1988 Mar 15; 263(8):3542-5. Lalazar A, Weisgraber KH, Rall SC, Giladi H, Innerarity TL, Levanon AZ, Boyles JK, Amit B, Gorecki M, Mahley RW. PMID: 2831187.
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    162. Metabolism of canine beta-very low density lipoproteins in normal and cholesterol-fed dogs. Arteriosclerosis. 1988 Mar-Apr; 8(2):130-9. Fainaru M, Funke H, Boyles JK, Ludwig EH, Innerarity TL, Mahley RW. PMID: 2831863.
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    163. Receptor binding activity of lipid recombinants of apolipoprotein B-100 thrombolytic fragments. J Lipid Res. 1987 Dec; 28(12):1410-23. Corsini A, Spilman CH, Innerarity TL, Arnold KS, Rall SC, Boyles JK, Mahley RW. PMID: 2828500.
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    164. Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells. J Lipid Res. 1987 Dec; 28(12):1482-94. Friedman G, Wernette-Hammond ME, Hui DY, Mahley RW, Innerarity TL. PMID: 2828502.
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    165. Structural relationship of human apolipoprotein B48 to apolipoprotein B100. J Clin Invest. 1987 Dec; 80(6):1794-8. Innerarity TL, Young SG, Poksay KS, Mahley RW, Smith RS, Milne RW, Marcel YL, Weisgraber KH. PMID: 3680528.
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    166. Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. Proc Natl Acad Sci U S A. 1987 Oct; 84(19):6919-23. Innerarity TL, Weisgraber KH, Arnold KS, Mahley RW, Krauss RM, Vega GL, Grundy SM. PMID: 3477815.
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    168. Lipoprotein uptake by neuronal growth cones in vitro. Science. 1987 May 22; 236(4804):959-62. Ignatius MJ, Shooter EM, Pitas RE, Mahley RW. PMID: 3576212.
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    169. Human apolipoprotein B: complete cDNA sequence and identification of structural domains of the protein. Biochem Soc Trans. 1987 Apr; 15(2):195-9. Scott J, Pease RJ, Powell LM, Wallis SC, McCarthy BJ, Mahley RW, Levy-Wilson B, Knott TJ. PMID: 3556259.
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    170. Mapping of human apolipoprotein B antigenic determinants. Arteriosclerosis. 1987 Mar-Apr; 7(2):166-75. Marcel YL, Innerarity TL, Spilman C, Mahley RW, Protter AA, Milne RW. PMID: 2437897.
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    171. Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. Exp Neurol. 1987 Feb; 95(2):323-35. Gebicke-Haerter PJ, Darby JK, Shooter EM, Riccardi VM, Weisgraber KH, Boyles JK, Mahley RW. PMID: 3100319.
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    172. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta. 1987 Jan 13; 917(1):148-61. Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW. PMID: 3539206.
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    175. The molecular basis of atherosclerosis: concepts derived from studies of lipoprotein metabolism and cell biology. Clin Invest Med. 1986 Nov; 9(4):304-8. Mahley RW. PMID: 3026707.
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    179. Identification of homozygosity for a human apolipoprotein A-I variant. J Lipid Res. 1986 Apr; 27(4):436-41. Rall SC, Weisgraber KH, Mahley RW, Ehnholm C, Schamaun O, Olaisen B, Blomhoff JP, Teisberg P. PMID: 3723016.
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    186. Type III hyperlipoproteinemia: a focus on lipoprotein receptor-apolipoprotein E2 interactions. Adv Exp Med Biol. 1986; 201:273-88. Innerarity TL, Hui DY, Bersot TP, Mahley RW. PMID: 3026150.
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    190. Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages. Arteriosclerosis. 1986 Jan-Feb; 6(1):114-22. Innerarity TL, Arnold KS, Weisgraber KH, Mahley RW. PMID: 3942555.
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    193. Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology. Circulation. 1985 Nov; 72(5):943-8. Mahley RW. PMID: 4042302.
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    194. Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins. J Biol Chem. 1985 Oct 05; 260(22):11934-43. Koo C, Innerarity TL, Mahley RW. PMID: 2995353.
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    196. Topographic study of sudanophilic lesions in cholesterol-fed minipigs by image analysis. Arteriosclerosis. 1985 Sep-Oct; 5(5):415-26. Cornhill JF, Barrett WA, Herderick EE, Mahley RW, Fry DL. PMID: 2412537.
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    197. Receptor interactions controlling lipoprotein metabolism. Can J Biochem Cell Biol. 1985 Aug; 63(8):898-905. Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. PMID: 2998579.
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    202. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci U S A. 1985 Jan; 82(1):203-7. Elshourbagy NA, Liao WS, Mahley RW, Taylor JM. PMID: 3918303.
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    226. Lipoprotein receptors and cholesterol homeostasis. Biochim Biophys Acta. 1983 May 24; 737(2):197-222. Mahley RW, Innerarity TL. PMID: 6303423.
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    227. Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia. J Clin Invest. 1983 Apr; 71(4):1023-31. Rall SC, Weisgraber KH, Innerarity TL, Mahley RW. PMID: 6300187.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    228. Regulation of hepatic lipoprotein receptors in the dog. Rapid regulation of apolipoprotein B,E receptors, but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids. J Clin Invest. 1983 Apr; 71(4):816-31. Angelin B, Raviola CA, Innerarity TL, Mahley RW. PMID: 6300188.
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    229. Apolipoprotein E and cholesterol metabolism. Klin Wochenschr. 1983 Mar 01; 61(5):225-32. Mahley RW. PMID: 6843048.
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    230. Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I. J Biol Chem. 1983 Feb 25; 258(4):2508-13. Weisgraber KH, Rall SC, Bersot TP, Mahley RW, Franceschini G, Sirtori CR. PMID: 6401735.
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    231. Foam cells in explants of atherosclerotic rabbit aortas have receptors for beta-very low density lipoproteins and modified low density lipoproteins. Arteriosclerosis. 1983 Jan-Feb; 3(1):2-12. Pitas RE, Innerarity TL, Mahley RW. PMID: 6297442.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    232. Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects. Proc Natl Acad Sci U S A. 1982 Aug; 79(15):4696-700. Rall SC, Weisgraber KH, Innerarity TL, Mahley RW. PMID: 6289314.
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    233. Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res. 1982 Aug; 23(6):911-4. Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C. PMID: 7130859.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    234. Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia. J Lipid Res. 1982 Jul; 23(5):702-14. Fainaru M, Mahley RW, Hamilton RL, Innerarity TL. PMID: 7119569.
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    235. Yucatan miniature swine as a model for diet-induced atherosclerosis. Atherosclerosis. 1982 May; 43(1):119-32. Reitman JS, Mahley RW, Fry DL. PMID: 7092978.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    236. Human apolipoprotein E. The complete amino acid sequence. J Biol Chem. 1982 Apr 25; 257(8):4171-8. Rall SC, Weisgraber KH, Mahley RW. PMID: 7068630.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    237. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem. 1982 Mar 10; 257(5):2518-21. Weisgraber KH, Innerarity TL, Mahley RW. PMID: 6277903.
      View in: PubMed   Mentions: 117     Fields:    Translation:Humans
    238. Modulating effects of canine high density lipoproteins on cholesteryl ester synthesis induced by beta-very low density lipoproteins in macrophages. Possible in vitro correlates with atherosclerosis. Arteriosclerosis. 1982 Mar-Apr; 2(2):114-24. Innerarity TL, Pitas RE, Mahley RW. PMID: 7065981.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    239. Atherogenic hyperlipoproteinemia. The cellular and molecular biology of plasma lipoproteins altered by dietary fat and cholesterol. Med Clin North Am. 1982 Mar; 66(2):375-402. Mahley RW. PMID: 7040843.
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    240. Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors. J Clin Invest. 1981 Nov; 68(5):1197-206. Mahley RW, Hui DY, Innerarity TL, Weisgraber KH. PMID: 6271808.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    241. Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. J Clin Invest. 1981 Oct; 68(4):1075-85. Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW. PMID: 6270194.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    242. Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem. 1981 Sep 10; 256(17):9077-83. Weisgraber KH, Rall SC, Mahley RW. PMID: 7263700.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansCells
    243. Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4378-82. Innerarity TL, Kempner ES, Hui DY, Mahley RW. PMID: 6270675.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    244. Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors. J Biol Chem. 1981 Jun 10; 256(11):5646-55. Hui DY, Innerarity TL, Mahley RW. PMID: 6263887.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    245. Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy. Arteriosclerosis. 1981 May-Jun; 1(3):177-85. Pitas RE, Innerarity TL, Weinstein JN, Mahley RW. PMID: 6895305.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    246. Chylomicron metabolism during dietary-induced hypercholesterolemia in dogs. J Lipid Res. 1981 May; 22(4):598-609. Melchior GW, Mahley RW, Buckhold DK. PMID: 7276736.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    247. Effect of arterial stretch on transmural albumin and Evan's blue dye transport. Am J Physiol. 1981 Apr; 240(4):H645-9. Fry DL, Mahley RW, Oh SY. PMID: 7223913.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    248. Cellular and molecular biology of lipoprotein metabolism in atherosclerosis. Diabetes. 1981; 30(Suppl 2):60-5. Mahley RW. PMID: 7297774.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    249. Aortic transmural serum protein transport: effect of concentration, time, and location. Am J Physiol. 1981 Jan; 240(1):H54-61. Fry DL, Mahley RW, Oh SY, Swyt CR. PMID: 7457622.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    250. The role of dietary fat and cholesterol in atherosclerosis and lipoprotein metabolism. West J Med. 1981 Jan; 134(1):34-42. Mahley RW. PMID: 7210661.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    251. Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B. J Biol Chem. 1980 Dec 25; 255(24):11775-81. Hui DY, Harmony JA, Innerarity TL, Mahley RW. PMID: 7440569.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    252. Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells. Requirements for homology for receptor binding activity. J Biol Chem. 1980 Dec 10; 255(23):11163-72. Innerarity TL, Pitas RE, Mahley RW. PMID: 6254962.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    253. A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family. J Clin Invest. 1980 Nov; 66(5):892-900. Franceschini G, Sirtori CR, Capurso A, Weisgraber KH, Mahley RW. PMID: 7430351.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    254. Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species. J Lipid Res. 1980 Nov; 21(8):970-80. Mahley RW, Innerarity TL, Brown MS, Ho YK, Goldstein JL. PMID: 7462813.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    255. A-Imilano apoprotein. Isolation and characterization of a cysteine-containing variant of the A-I apoprotein from human high density lipoproteins. J Clin Invest. 1980 Nov; 66(5):901-7. Weisgraber KH, Bersot TP, Mahley RW, Franceschini G, Sirtori CR. PMID: 6776144.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    256. Effect of cholesterol supplementation of diets of thyroidectomized dogs on the fatty acid composition of erythrocyte phospholipids and plasma phosphatidylcholine. Biochim Biophys Acta. 1980 Sep 08; 619(3):699-704. Pitas RE, Nelson GJ, Mahley RW. PMID: 7459375.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    257. Receptor binding of cholesterol-induced high-density lipoproteins containing predominantly apoprotein E to cultured fibroblasts with mutations at the low-density lipoprotein receptor locus. Biochemistry. 1980 Sep 02; 19(18):4359-65. Innerarity TL, Pitas RE, Mahley RW. PMID: 7417411.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    258. Quantitative microautoradiography of arteries: comparison of radioactivity to silver. Am J Physiol. 1980 Aug; 239(2):H289-95. Fry DL, Mahley RW, Oh SY, Lewis SJ, Plowman F, Swyt CR. PMID: 6250414.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    259. Comparison of the human, canine and swine E apoproteins. Biochem Biophys Res Commun. 1980 Jul 16; 95(1):374-80. Weisgraber KH, Troxler RF, Rall SC, Mahley RW. PMID: 7417263.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    260. Cell surface receptor binding of phospholipid . protein complexes containing different ratios of receptor-active and -inactive E apoprotein. J Biol Chem. 1980 Jun 10; 255(11):5454-60. Pitas RE, Innerarity TL, Mahley RW. PMID: 7372644.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    261. Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process. J Biol Chem. 1980 Mar 10; 255(5):1804-7. Sherrill BC, Innerarity TL, Mahley RW. PMID: 7354059.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    262. Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins. J Biol Chem. 1980 Mar 10; 255(5):1839-48. Goldstein JL, Ho YK, Brown MS, Innerarity TL, Mahley RW. PMID: 7354064.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    263. Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography. J Lipid Res. 1980 Mar; 21(3):316-25. Weisgraber KH, Mahley RW. PMID: 7381326.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    264. Atherosclerosis in the Erythrocebus patas, an old world monkey. Am J Pathol. 1980 Feb; 98(2):401-24. Mahley RW, Johnson DK, Pucak GJ, Fry DL. PMID: 6766672.
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    265. Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys. Proc Natl Acad Sci U S A. 1980 Jan; 77(1):225-9. Mahley RW, Weisgraber KH, Melchior GW, Innerarity TL, Holcombe KS. PMID: 6767236.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    266. Alterations in metabolic activity of plasma lipoproteins following selective chemical modification of the apoproteins. Ann N Y Acad Sci. 1980; 348:265-80. Mahley RW, Innerarity TL, Weisgraber KH. PMID: 6994562.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    267. Changes induced in the lipoproteins of Yucatan miniature swine by cholesterol feeding. Biochim Biophys Acta. 1979 Dec 18; 575(3):446-57. Reitman JS, Mahley RW. PMID: 518896.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    268. Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors. Biochim Biophys Acta. 1979 Oct 26; 575(1):81-91. Mahley RW, Weisgraber KH, Innerarity TL. PMID: 228738.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    269. Altered metabolism (in vivo and in vitro) of plasma lipoproteins after selective chemical modification of lysine residues of the apoproteins. J Clin Invest. 1979 Sep; 64(3):743-50. Mahley RW, Innerarity TL, Weisgraber KB, Oh SY. PMID: 224077.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    270. Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J Biol Chem. 1979 May 25; 254(10):4186-90. Innerarity TL, Pitas RE, Mahley RW. PMID: 220235.
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    271. Effects of diets high in saturated fat and cholesterol on the lipid composition of canine platelets. Lipids. 1979 May; 14(5):469-77. Pitas RE, Nelson GJ, Jaffe RM, Mahley RW. PMID: 459712.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    272. Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc. Proc Natl Acad Sci U S A. 1979 May; 76(5):2311-5. Pitas RE, Innerarity TL, Arnold KS, Mahley RW. PMID: 221921.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    273. Accelerated clearance of low-density and high-density lipoproteins and retarded clearance of E apoprotein-containing lipoproteins from the plasma of rats after modification of lysine residues. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1746-50. Mahley RW, Weisgraber KH, Innerarity TL, Windmueller HG. PMID: 221905.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    274. Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts. J Biol Chem. 1978 Dec 25; 253(24):9053-62. Weisgraber KH, Innerarity TL, Mahley RW. PMID: 214439.
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    275. Isolation and characterization of an apoprotein from the d less than 1.006 lipoproteins of human and canine lymph homologous with the rat A-IV apoprotein. Biochem Biophys Res Commun. 1978 Nov 14; 85(1):287-92. Weisgraber KH, Bersot TP, Mahley RW. PMID: 217374.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    276. Alterations in human high-density lipoproteins, with or without increased plasma-cholesterol, induced by diets high in cholesterol. Lancet. 1978 Oct 14; 2(8094):807-9. Mahley RW, Innerarity TL, Bersot TP, Lipson A, Margolis S. PMID: 81362.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    277. Structural organization of the lipoprotein HDLc from atherosclerotic swine. Structural features relating the particle surface and core. Biochemistry. 1978 Sep 19; 17(19):3930-3. Atkinson D, Tall AR, Small DM, Mahley RW. PMID: 213098.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    278. Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J Biol Chem. 1978 Sep 10; 253(17):6281-8. Weisgraber KH, Mahley RW. PMID: 210174.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    279. Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex. J Biol Chem. 1978 Sep 10; 253(17):6289-95. Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP. PMID: 210175.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    280. delta 15,18-tetracosadienoic acid content of sphingolipids from platelets and erythrocytes of animals fed diets high in saturated or polyunsaturated fats. Lipids. 1978 Aug; 13(8):551-6. Pitas RE, Nelson GJ, Jaffe RM, Mahley RW. PMID: 703532.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    281. Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins. Biochemistry. 1978 Apr 18; 17(8):1440-7. Innerarity TL, Mahley RW. PMID: 206278.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    282. Properties of lipoproteins responsible for high affinity binding to cell surface receptors of fibroblasts and smooth muscle cells. Adv Exp Med Biol. 1978; 109:99-127. Mahley RW, Innerarity TL. PMID: 364953.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    283. Characterization of the lipoproteins of atherosclerotic swine. J Biol Chem. 1977 Oct 25; 252(20):7288-93. Tall AR, Atkinson D, Small DM, Mahley RW. PMID: 198408.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    284. Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins. J Biol Chem. 1977 Oct 25; 252(20):7279-87. Mahley RW, Innerarity TL, Pitas RE, Weisgraber KH, Brown JH, Gross E. PMID: 198407.
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    285. The rat arginine-rich apoprotein and its redistribution following injection of iodinated lipoproteins into normal and hypercholesterolemic rats. Atherosclerosis. 1977 Oct; 28(2):121-40. Weisgraber KH, Mahley RW, Assmann G. PMID: 199205.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    286. Simultaneous accumulation of Evans blue dye and albumin in the canine aortic wall. Am J Physiol. 1977 Jul; 233(1):H66-79. Fry DL, Mahley RW, Weisgraber KH, Oh SY. PMID: 879338.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    287. Interaction of canine and swine lipoproteins with the low density lipoprotein receptor of fibroblasts as correlated with heparin/manganese precipitability. J Biol Chem. 1977 Jun 10; 252(11):3980-6. Mahley RW, Innerarity TL. PMID: 193851.
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    288. Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat. J Lipid Res. 1977 May; 18(3):314-24. Mahley RW, Holcombe KS. PMID: 194008.
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    289. Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro. Am J Pathol. 1977 Apr; 87(1):205-26. Mahley RW, Innerarity TL, Weisgraber KH, Fry DL. PMID: 192082.
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    290. Lipoproteins and arterial smooth muscle cells: regulation of cellular metabolism by swine lipoproteins. Adv Exp Med Biol. 1977; 82:909-14. Mahley RW. PMID: 920447.
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    291. Swine aortic smooth muscle in tissue culture. Some effects of purified swine lipoproteins on cell growth and morphology. Circ Res. 1976 Sep; 39(3):415-24. Brown BG, Mahley R, Assmann G. PMID: 182413.
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    292. Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey. Biochemistry. 1976 Jul 13; 15(14):2979-85. Mahley RW, Weisgraber KH, Innerarity T. PMID: 182200.
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    293. Thrombosis in association with atherosclerosis induced by dietary perturbations in dogs. Science. 1976 Jun 11; 192(4244):1139-41. Mahley R, Nelson AW, Ferrans VJ, Fry DL. PMID: 1273587.
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    294. Characterization of the plasma lipoproteins and apoproteins of the Erythrocebus patas monkey. Biochemistry. 1976 May 04; 15(9):1928-33. Mahley RW, Weisgraber KH, Innerarity T, Brewer HB. PMID: 178359.
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    295. Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts. J Biol Chem. 1976 Apr 25; 251(8):2395-8. Bersot TP, Mahley RW, Brown MS, Goldstein JL. PMID: 177413.
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    296. Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry. 1975 Jul; 14(13):2817-23. Mahley RW, Weisgraber KH, Innerarity T, Brewer HB, Assmann G. PMID: 167808.
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    297. Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia. Circ Res. 1974 Nov; 35(5):722-33. Mahley RW, Weisgraber KH, Innerarity T. PMID: 4138629.
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    298. Canine lipoproteins and atherosclerosis. I. Isolation and characterization of plasma lipoproteins from control dogs. Circ Res. 1974 Nov; 35(5):713-21. Mahley RW, Weisgraber KH. PMID: 4138628.
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    299. Incorporation of sialic acid into sialidase-treated apolipoprotein of human, very low density lipoprotein by a pork liver sialytransferase. Can J Biochem. 1974 Aug; 52(8):654-64. Wetmore S, Mahley RW, Brown WV, Schachter H. PMID: 4373146.
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    300. An electrophoretic method for the quantitative isolation of human and swine plasma lipoproteins. Biochemistry. 1974 Apr 23; 13(9):1964-9. Mahley RW, Weisgraber KH. PMID: 4366269.
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    301. Cholesterol esterification by the rat liver Golgi apparatus. Scand J Clin Lab Invest Suppl. 1974; 137:23-8. Assmann G, Mahley RW, Davis B, Holcombe KS. PMID: 4367598.
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    302. Role of plasma lipoproteins in cortisone-induced fat embolism. Am J Pathol. 1972 Jan; 66(1):43-64. Mahley RW, Gray ME, LeQuire VS. PMID: 5009252.
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    303. Lipoproteins associated with the Golgi apparatus isolated from epithelial cells of rat small intestine. Lab Invest. 1971 Nov; 25(5):435-44. Mahley RW, Bennett BD, Morré DJ, Gray ME, Thistlethwaite W, LeQuire VS. PMID: 4109439.
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    304. Identity of very low density lipoprotein apoproteins of plasma and liver Golgi apparatus. Science. 1970 Apr 17; 168(3929):380-2. Mahley RW, Bersot TP, LeQuire VS, Levy RI, Windmueller HG, Brown WV. PMID: 4985196.
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    305. Barr body studies from the hair. Lancet. 1970 Apr 11; 1(7650):789. Engel E, Culbertson JC, Mahley RW, Fenichel GM. PMID: 4191300.
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    306. Isolation of a Golgi apparatus-rich fraction from rat liver. I. Method and morphology. J Cell Biol. 1970 Mar; 44(3):484-91. Morré DJ, Hamilton RL, Mollenhauer HH, Mahley RW, Cunningham WP, Cheetham RD, Lequire VS. PMID: 4905956.
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    307. Characterization of lipoprotein particles isolated from the Golgi apparatus of rat liver. J Lipid Res. 1969 Jul; 10(4):433-9. Mahley RW, Hamilton RL, Lequire VS. PMID: 4978881.
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    308. Lipid transport in liver. II. Electron microscopic and biochemical studies of alterations in lipoprotein transport induced by cortisone in the rabbit. Lab Invest. 1968 Oct; 19(4):358-69. Mahley RW, Gray ME, Hamilton RL, LeQuire VS. PMID: 5699116.
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