Evan Feinberg, PhD
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Title(s) | Assistant Professor, Anatomy |
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School | School of Medicine |
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Phone | 415-502-3619 |
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vCard | Download vCard |
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Biography Harvard Univeristy | A.B. | | | The Rockefeller University | Ph.D. | | | Harvard University | Postdoctoral fellowship | | |
Overview My lab (www.evanfeinberglab.com) aims to understand how sensory input is represented in the brain and transformed into behavioral commands. We study this problem in the superior colliculus (SC), a structure comprising functionally diverse sensory and motor neurons interleaved with fibers from myriad cortical and subcortical areas. This remarkable neuroanatomy poises the SC as an integrative hub, but has also hindered efforts to dissect SC circuitry using classical methods, such as lesions, that offer poor spatial and temporal resolution. In order to record from and manipulate genetically defined cell types, we study the mouse SC, where we capitalize on an experimental preparation I developed that allows two-photon imaging of neuronal population activity in the SC of awake animals. We apply these methods to decipher computations in the context of quantitative behavioral assays. Our long-term goal is to understand how the brain encodes information from input to output.
ORNG Applications Bibliographic
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Feinberg EH, Meister M. Orientation columns in the mouse superior colliculus. Nature. 2015 Mar 12; 519(7542):229-32. PMID: 25517100.
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Wickersham IR, Feinberg EH. New technologies for imaging synaptic partners. Curr Opin Neurobiol. 2012 Feb; 22(1):121-7. PMID: 22221865.
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Macosko EZ, Pokala N, Feinberg EH, Chalasani SH, Butcher RA, Clardy J, Bargmann CI. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. Nature. 2009 Apr 30; 458(7242):1171-5. PMID: 19349961; PMCID: PMC2760495.
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Feinberg EH, Vanhoven MK, Bendesky A, Wang G, Fetter RD, Shen K, Bargmann CI. GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems. Neuron. 2008 Feb 07; 57(3):353-63. PMID: 18255029.
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Winston WM, Sutherlin M, Wright AJ, Feinberg EH, Hunter CP. Caenorhabditis elegans SID-2 is required for environmental RNA interference. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10565-70. PMID: 17563372; PMCID: PMC1965553.
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Chalasani SH, Feinberg EH, Hilliard MA. Global 'worming'. Genome Biol. 2007; 8(9):314. PMID: 17875222; PMCID: PMC2375015.
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Hunter CP, Winston WM, Molodowitch C, Feinberg EH, Shih J, Sutherlin M, Wright AJ, Fitzgerald MC. Systemic RNAi in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 2006; 71:95-100. PMID: 17381285.
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García-García MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):5913-9. PMID: 15755804; PMCID: PMC1087930.
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Feinberg EH, Hunter CP. Transport of dsRNA into cells by the transmembrane protein SID-1. Science. 2003 Sep 12; 301(5639):1545-7. PMID: 12970568.
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