Iris Otani, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address350 Parnassus
San Francisco CA 94117
Phone415-353-2725
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    Stanford UniversityBSBiology
    UCSD School of MedicineMD
    Santa Clara Valley Medical Center Internal Medicine ResidencyInternal Medicine
    Massachusetts General Hospital Allergy/Immunology Fellowship2016Allergy/Immunology
    University of California, San Francisco2020Diversity, Equity, and Inclusion Champion Training

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    Dr. Iris Otani is an allergist/immunologist with expertise in drug allergy and secondary hypogammaglobulinemia. She is the Medical and Quality Improvement Director for Adult Allergy/Immunology and sees patients in the UCSF Parnassus Allergy/Immunology and Drug Allergy Testing Clinics. Her academic interests also include medical education and quality improvement. She is the associate program director for the UCSF Allergy/Immunology Fellowship Training Program. She has pursued further training in quality improvement and was selected to join the Learning Health System Coach program at UCSF Health, a faculty development program for faculty who lead continuous improvement in their clinical settings. She serves on the editorial board of the Annals of Allergy Asthma & Immunology and on the In-Training Exam Committee for the American Academy of Allergy Asthma & Immunology.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. COVID-19 Vaccine Administration in Patients with Reported Reactions to Polyethylene Glycol- and Polysorbate-Containing Therapeutics. Ann Allergy Asthma Immunol. 2022 Mar 11. Otani IM, Tsao LR, Tang M. PMID: 35288274; PMCID: PMC8916834.
      View in: PubMed   Mentions:
    2. Practical Guidance for the Diagnosis and Management of Secondary Hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees. J Allergy Clin Immunol. 2022 Feb 14. Otani IM, Lehman HK, Jongco AM, Tsao LR, Azar A, Tarrant T, Engel E, Walter JE, Truong TQ, Khan DA, Ballow M, Cunningham-Rundles C, Lu H, Kwan M, Barmettler S. PMID: 35176351.
      View in: PubMed   Mentions:
    3. Drug Allergy Delabeling Programs: Recent Strategies and Targeted Populations. Clin Rev Allergy Immunol. 2022 Jan 15. Anstey KM, Tsao L, Otani IM. PMID: 35031956.
      View in: PubMed   Mentions:
    4. M060 SUCCESSFUL REINTRODUCTION OF MOGAMULIZUMAB VIA OUTPATIENT ONE DILUTION DESENSITIZATION PROTOCOLS FOLLOWING RECURRENT DELAYED CUTANEOUS REACTIONS. Annals of Allergy Asthma & Immunology. 2021 Nov 1; 127(5):s75. Young YF, Pincus PL, Ai AW, Otani OI. .
      View in: Publisher Site   Mentions:
    5. One-Bag Desensitization Protocols in the Management of Chemotherapy Hypersensitivity. J Allergy Clin Immunol Pract. 2021 11; 9(11):4055-4059. Tsao LR, Otani IM. PMID: 34749948.
      View in: PubMed   Mentions:
    6. Perceptions Around Lung Transplant-Associated Hypogammaglobulinemia. J Clin Immunol. 2021 11; 41(8):1940-1942. Lew J, Casey M, Leard LE, Hays S, Otani IM. PMID: 34351551.
      View in: PubMed   Mentions:    Fields:    
    7. Hypersensitivity Reactions to Platinum Agents and Taxanes. Clin Rev Allergy Immunol. 2021 Aug 02. Tsao LR, Young FD, Otani IM, Castells MC. PMID: 34338975.
      View in: PubMed   Mentions:    Fields:    
    8. Enabling antibiotic allergy evaluations and reintroduction of first-line antibiotics for patients with cystic fibrosis. Ann Allergy Asthma Immunol. 2021 10; 127(4):456-461. Anstey KM, Choi L, Dawson D, Kleinhenz ME, Otani IM. PMID: 34048884.
      View in: PubMed   Mentions:    Fields:    
    9. Impact of Rapid Transition to Telemedicine-Based Delivery on Allergy/Immunology Care During COVID-19. J Allergy Clin Immunol Pract. 2021 Jul; 9(7):2672-2679.e2. Tsao LR, Villanueva SA, Pines DA, Pham MN, Choo EM, Tang MC, Otani IM. PMID: 33894393; PMCID: PMC8061180.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Hypogammaglobulinemia Identification and Management in Lung Transplant Patients: Survey of Provider Practices. The Journal of Heart and Lung Transplantation. 2021 Apr 1; 40(4):s381-s382. Casey CM, Lew LJ, Hays HS, Leard LL, Otani OI. .
      View in: Publisher Site   Mentions:
    11. Screening for Severe Hypogammaglobulinemia in Lung Transplant Recipients. The Journal of Heart and Lung Transplantation. 2021 Apr 1; 40(4):s381. Otani OI, Lew LJ, Casey CM, Perez PA, Zhang ZL, Leard LL, Hays HS. .
      View in: Publisher Site   Mentions:
    12. Perioperative use and safety of cephalosporin antibiotics in patients with documented penicillin allergy. J Allergy Clin Immunol Pract. 2021 08; 9(8):3203-3207.e1. Anstey KM, Anstey JE, Doernberg SB, Chen LL, Otani IM. PMID: 33766583.
      View in: PubMed   Mentions: 1     Fields:    
    13. Rapid Adoption of Video Visits and Return-to-Clinic Procedures to Maintain Access to Allergy/Immunology Care Delivery During COVID-19. Journal of Allergy and Clinical Immunology. 2021 Feb 1; 147(2):ab112. Tsao TL, Ferraris FS, Pines PD, Choo CE, Pham PM, Tang TM, Leard LL, Gross GA, Ashbaugh AC, Choi CL, Otani OI. .
      View in: Publisher Site   Mentions:
    14. Zoonotic coronavirus epidemics: Severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019. Ann Allergy Asthma Immunol. 2021 Apr; 126(4):321-337. Fung M, Otani I, Pham M, Babik J. PMID: 33310180; PMCID: PMC7834857.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. A055 EXPANDING PENICILLIN ALLERGY EVALUATION FOR PRENATAL PATIENTS. Annals of Allergy Asthma & Immunology. 2020 Nov 1; 125(5):s10-s11. Tsao TL, Irani IR, Rosenbluth RG, Choi CL, Otani OI. .
      View in: Publisher Site   Mentions:
    16. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs. J Allergy Clin Immunol Pract. 2020 10; 8(9S):S16-S116. Broyles AD, Banerji A, Barmettler S, Biggs CM, Blumenthal K, Brennan PJ, Breslow RG, Brockow K, Buchheit KM, Cahill KN, Cernadas J, Chiriac AM, Crestani E, Demoly P, Dewachter P, Dilley M, Farmer JR, Foer D, Fried AJ, Garon SL, Giannetti MP, Hepner DL, Hong DI, Hsu JT, Kothari PH, Kyin T, Lax T, Lee MJ, Lee-Sarwar K, Liu A, Logsdon S, Louisias M, MacGinnitie A, Maciag M, Minnicozzi S, Norton AE, Otani IM, Park M, Patil S, Phillips EJ, Picard M, Platt CD, Rachid R, Rodriguez T, Romano A, Stone CA, Torres MJ, Verdú M, Wang AL, Wickner P, Wolfson AR, Wong JT, Yee C, Zhou J, Castells M. PMID: 33039007.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Neurologic Conditions and Symptoms Reported Among Common Variable Immunodeficiency Patients in the USIDNET. J Clin Immunol. 2020 11; 40(8):1181-1183. Lee M, Nguyen J, Fuleihan R, Gundling K, Cunningham-Rundles C, Otani IM. PMID: 32901355; PMCID: PMC8241239.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    18. Patient Characteristics and Concerns about Drug Allergy: A Report from the United States Drug Allergy Registry. J Allergy Clin Immunol Pract. 2020 10; 8(9):2958-2967. Blumenthal KG, Harkness T, Phillips EJ, Ramsey A, Banerji A, Samarakoon U, Stone C, Fu X, Khan DA, Otani I, Camargo CA, Zhang Y, Donelan K, USDAR Study Team. PMID: 32853819.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Antibiotic adverse reactions in adult cystic fibrosis patients. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3631-3633.e1. Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM. PMID: 32673878.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Novel Roles for Platinum and Taxane Agent Skin Testing in Risk Stratification of Chemotherapy Hypersensitivity. J Allergy Clin Immunol Pract. 2020 05; 8(5):1665-1667. Otani IM, Castells M. PMID: 32389278.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Hypogammaglobulinemia in Patients with Neuromyelitis Optica (NMO). Journal of Allergy and Clinical Immunology. 2020 Feb 1; 145(2):ab215. Tsao TL, Bove BR, Krishnakumar KT, Otani OI. .
      View in: Publisher Site   Mentions:
    22. Development of an Antibiotic Allergy Program to Address a Clinical Gap in the Antibiotic Stewardship of Cystic Fibrosis Patients. Journal of Allergy and Clinical Immunology. 2020 Feb 1; 145(2):ab167. Anstey AK, Kleinhenz KM, Otani OI. .
      View in: Publisher Site   Mentions:
    23. Primary Immunodeficiency Diagnoses seen in Patients with Chronic Lung Disease: Findings from the USIDNET Registry. Journal of Allergy and Clinical Immunology. 2020 Feb 1; 145(2):ab178. Lee LM, Routes RJ, Marsh MR, Fuleihan FR, Lugar LP, Cunningham-Rundles CC, Garabedian GE, Otani OI. .
      View in: Publisher Site   Mentions:
    24. A006 ADVERSE DRUG REACTIONS IN CYSTIC FIBROSIS PATIENTS: USING DATA TO DEVELOP AN ANTIBIOTIC EVALUATION PROGRAM. Annals of Allergy Asthma & Immunology. 2019 Nov 1; 123(5):s4. Anstey AK, Kleinhenz KM, Otani OI. .
      View in: Publisher Site   Mentions:
    25. 2543. Implementation of a Fellow-Driven ?-Lactam Allergy De-Labeling Initiative on an Inpatient ID Consult Service. Open Forum Infectious Diseases. 2019 Oct 23; 6(Supplement_2):s883-s883. Mulliken MJ, Bystritsky BR, Anstey AK, Otani OI, Doernberg DS. .
      View in: Publisher Site   Mentions:
    26. Beta-lactam Administration Patterns at a Safety-net Hospital with Limited Access to Inpatient Penicillin Skin Testing. Journal of Allergy and Clinical Immunology. 2019 Feb 1; 143(2):ab31. Song SP, Hwa HM, Eng EJ, Otani OI. .
      View in: Publisher Site   Mentions:
    27. Perioperative Use and Safety of Cephalosporin Antibiotics in Patients with Documented Penicillin Allergy. Journal of Allergy and Clinical Immunology. 2019 Feb 1; 143(2):ab29. Anstey AK, Anstey AJ, Hilts-Horeczko HA, Doernberg DS, Chen CL, Otani OI. .
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    28. Strategies for Discontinuing Omalizumab in Patients with Chronic Urticaria: Real-World Findings. Journal of Allergy and Clinical Immunology. 2019 Feb 1; 143(2):ab302. Seghezzo SS, Tsao TL, Otani OI. .
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    29. Hypogammaglobulinemia in Multiple Sclerosis Patients Receiving Disease-Modifying Immunomodulatory Agents. Journal of Allergy and Clinical Immunology. 2019 Feb 1; 143(2):ab16. Tsao TL, Otani OI, Bove BR. .
      View in: Publisher Site   Mentions:
    30. Development of a health-related quality of life instrument for patients with hereditary angioedema living in the United States. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1679-1683.e7. Busse PJ, Christiansen SC, Birmingham JM, Overbey JR, Banerji A, Otani IM, Lumry W, Goryachkovsky A, Zuraw BL. PMID: 30550806.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis. Clin Case Rep. 2018 Sep; 6(9):1834-1840. Otani IM, Carroll RW, Yager P, Kroshinsky D, Murphy S, Hornick JL, Akin C, Castells M, Walter JE. PMID: 30214774; PMCID: PMC6132108.
      View in: PubMed   Mentions: 2  
    32. Cutaneous Manifestations of Reactions to Biologics. Curr Allergy Asthma Rep. 2018 02 21; 18(2):12. Otani IM, Levin AS, Banerji A. PMID: 29464437.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Impact of a Novel Radiocontrast Media Reaction Treatment Algorithm in Simulation Settings of Anaphylaxis. Journal of Allergy and Clinical Immunology. 2018 Feb 1; 141(2):ab34. Otani OI, Otrakji OA, Holtzman HN, Iandoli IM, Blumenthal BK, Banerji BA, Salazar SG. .
      View in: Publisher Site   Mentions:
    34. Documentation of Adverse Drug Reactions in Electronic Medical Records: Areas for Improvement and Impact on Clinical Outcomes. Journal of Allergy and Clinical Immunology. 2018 Feb 1; 141(2):ab168. Nguyen NJ, Otani OI. .
      View in: Publisher Site   Mentions:
    35. Chapter 23 Corticosteroids. Drug Allergy Testing. 2018 Jan 1; 261-268. Otani OI. .
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    36. Utility of Risk Stratification for Paclitaxel Hypersensitivity Reactions. J Allergy Clin Immunol Pract. 2018 Jul - Aug; 6(4):1266-1273.e2. Otani IM, Lax T, Long AA, Slawski BR, Camargo CA, Banerji A. PMID: 28986119.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. Platinum Chemotherapy Hypersensitivity: Prevalence and Management. Immunol Allergy Clin North Am. 2017 11; 37(4):663-677. Otani IM, Wong J, Banerji A. PMID: 28965633.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    38. Acquired C1 Inhibitor Deficiency. Immunol Allergy Clin North Am. 2017 08; 37(3):497-511. Otani IM, Banerji A. PMID: 28687105.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2017 05; 37(2):369-396. Otani IM, Nadeau KC. PMID: 28366483.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Gastrointestinal Manifestations in X-linked Agammaglobulinemia. J Clin Immunol. 2017 Apr; 37(3):287-294. Barmettler S, Otani IM, Minhas J, Abraham RS, Chang Y, Dorsey MJ, Ballas ZK, Bonilla FA, Ochs HD, Walter JE. PMID: 28236219; PMCID: PMC5414010.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    41. Subcutaneous Icatibant for the Treatment of Hereditary Angioedema Attacks: Comparison of Home Self-Administration with Administration at a Medical Facility. J Allergy Clin Immunol Pract. 2017 Mar - Apr; 5(2):442-447.e1. Otani IM, Lumry WR, Hurwitz S, Li HH, Craig TJ, Holtzman NS, Iandoli MI, Tucker J, Riedl MA, Zuraw BL, Banerji A. PMID: 27818136.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Emergency Department Management of Hereditary Angioedema Attacks: Patient Perspectives. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):128-134.e4. Otani IM, Christiansen SC, Busse P, Camargo CA, Zuraw BL, Riedl MA, Banerji A. PMID: 27665386.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):107-113.e1. Levin AS, Otani IM, Lax T, Hochberg E, Banerji A. PMID: 27497683.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    44. Immediate and Delayed Hypersensitivity Reactions to Proton Pump Inhibitors: Evaluation and Management. Curr Allergy Asthma Rep. 2016 Mar; 16(3):17. Otani IM, Banerji A. PMID: 26810177.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    45. Immediate and Delayed Hypersensitivity Reactions to Corticosteroids: Evaluation and Management. Curr Allergy Asthma Rep. 2016 Mar; 16(3):18. Otani IM, Banerji A. PMID: 26857016.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. Subcutaneous Icatibant for the Treatment of Acute Attacks of Hereditary Angioedema: Comparison of Self-Administration to Administration at a Medical Facility. Journal of Allergy and Clinical Immunology. 2016 Feb 1; 137(2):ab250. Otani OI, Lumry LW, Li LH, Chase CC, Craig CT, Riedl RM, Zuraw ZB, Banerji BA. .
      View in: Publisher Site   Mentions:
    47. A role for vancomycin epicutaneous skin testing in the evaluation of perioperative anaphylaxis. J Allergy Clin Immunol Pract. 2015 Nov-Dec; 3(6):984-5. Otani IM, Kuhlen JL, Blumenthal KG, Guyer A, Banerji A. PMID: 26246124; PMCID: PMC4641770.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    48. Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies. Allergy Asthma Clin Immunol. 2014; 10(1):57. Arasi S, Otani IM, Klingbeil E, Bégin P, Kearney C, Dominguez TL, Block WM, O'Riordan G, Nadeau KC. PMID: 25788951; PMCID: PMC4363059.
      View in: PubMed   Mentions: 15  
    49. Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy Asthma Clin Immunol. 2014; 10(1):25. Otani IM, Bégin P, Kearney C, Dominguez TL, Mehrotra A, Bacal LR, Wilson S, Nadeau K. PMID: 24860608; PMCID: PMC4032627.
      View in: PubMed   Mentions: 20  
    50. Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2013 Jun; 131(6):1576-82. Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS. PMID: 23623266; PMCID: PMC3699422.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    51. Multi-Allergen Oral Immunotherapy Improves Quality of Life in Subjects with Food Allergies. Journal of Allergy and Clinical Immunology. 2013 Feb 1; 131(2):ab58. Otani OI, Dominguez DT, Sciancalepore SA, Mehrotra MA, Pineda PD, Nadeau NK. .
      View in: Publisher Site   Mentions:
    52. The Effect of Anti-IL-5 Therapy on Esophageal Mastocytosis in Pediatric Eosinophilic Esophagitis. Journal of Allergy and Clinical Immunology. 2012 Feb 1; 129(2):ab202. Otani OI, Bhagat BM, Newbury NR, Dohil DR, Broide BD, Aceves AS. .
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    53. Monomeric IgE and mast cell development, survival and function. Adv Exp Med Biol. 2011; 716:29-46. Kashiwakura J, Otani IM, Kawakami T. PMID: 21713650.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    54. A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohort. Genet Med. 2007 Jul; 9(7):413-26. Putcha GV, Bejjani BA, Bleoo S, Booker JK, Carey JC, Carson N, Das S, Dempsey MA, Gastier-Foster JM, Greinwald JH, Hoffmann ML, Jeng LJ, Kenna MA, Khababa I, Lilley M, Mao R, Muralidharan K, Otani IM, Rehm HL, Schaefer F, Seltzer WK, Spector EB, Springer MA, Weck KE, Wenstrup RJ, Withrow S, Wu BL, Zariwala MA, Schrijver I. PMID: 17666888.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    55. Enhancement of IGE-induced mediator release from rat peritoneal mast cells by serum-treated zymosan. Cell Immunol. 1984 Sep; 87(2):400-10. Otani I, Conrad DH, Ruddy S. PMID: 6205769.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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