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Iris Otani, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address350 Parnassus
San Francisco CA 94117
Phone415-353-2725
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    Collapse Education and Training
    Stanford UniversityBSBiology
    UCSD School of MedicineMD
    Santa Clara Valley Medical Center Internal Medicine ResidencyInternal Medicine
    Massachusetts General Hospital Allergy/Immunology Fellowship2016Allergy/Immunology
    UCSF Medical Center Learning Health Systems Coach Certification ProgramongoingContinuous Improvement

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    Collapse Overview
    Dr. Iris Otani is an allergist and immunologist with specific expertise in drug allergies, secondary hypogammaglobulinemia, and eosinophilic esophagitis. She is the associate program director of the UCSF allergy and immunology fellowship and the medical and quality improvement director for the Allergy & Immunology Clinic. She has led several multi-disciplinary collaborations to build innovative clinical treatment programs for drug allergy, including a cystic fibrosis antibiotic allergy evaluation program, inpatient beta-lactam antibiotic allergy evaluation program, and prenatal penicillin allergy evaluation program. She has published in the area of chemotherapy hypersensitivity and is collaborating with the Oncology division to standardize chemotherapy hypersensitivity evaluation and management. She has developed a program for secondary hypogammaglobulinemia screening and management in collaboration with the UCSF Lung Transplant Program.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A055 EXPANDING PENICILLIN ALLERGY EVALUATION FOR PRENATAL PATIENTS. Annals of Allergy Asthma & Immunology. 2020 Nov 1; 125(5):s10-s11. L. Tsao, R. Irani, G. Rosenbluth, L. Choi, I. Otani. .
      View in: Publisher Site   Mentions:
    2. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs. J Allergy Clin Immunol Pract. 2020 Oct; 8(9S):S16-S116. Broyles AD, Banerji A, Barmettler S, Biggs CM, Blumenthal K, Brennan PJ, Breslow RG, Brockow K, Buchheit KM, Cahill KN, Cernadas J, Chiriac AM, Crestani E, Demoly P, Dewachter P, Dilley M, Farmer JR, Foer D, Fried AJ, Garon SL, Giannetti MP, Hepner DL, Hong DI, Hsu JT, Kothari PH, Kyin T, Lax T, Lee MJ, Lee-Sarwar K, Liu A, Logsdon S, Louisias M, MacGinnitie A, Maciag M, Minnicozzi S, Norton AE, Otani IM, Park M, Patil S, Phillips EJ, Picard M, Platt CD, Rachid R, Rodriguez T, Romano A, Stone CA, Torres MJ, Verdú M, Wang AL, Wickner P, Wolfson AR, Wong JT, Yee C, Zhou J, Castells M. PMID: 33039007.
      View in: PubMed   Mentions:    Fields:    
    3. Neurologic Conditions and Symptoms Reported Among Common Variable Immunodeficiency Patients in the USIDNET. J Clin Immunol. 2020 Nov; 40(8):1181-1183. Lee M, Nguyen J, Fuleihan R, Gundling K, Cunningham-Rundles C, Otani IM. PMID: 32901355.
      View in: PubMed   Mentions:    Fields:    
    4. Patient Characteristics and Concerns about Drug Allergy: A Report from the United States Drug Allergy Registry. J Allergy Clin Immunol Pract. 2020 Oct; 8(9):2958-2967. Blumenthal KG, Harkness T, Phillips EJ, Ramsey A, Banerji A, Samarakoon U, Stone C, Fu X, Khan DA, Otani I, Camargo CA, Zhang Y, Donelan K. PMID: 32853819.
      View in: PubMed   Mentions:    Fields:    
    5. Antibiotic adverse reactions in adult cystic fibrosis patients. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3631-3633.e1. Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM. PMID: 32673878.
      View in: PubMed   Mentions:    Fields:    
    6. Novel Roles for Platinum and Taxane Agent Skin Testing in Risk Stratification of Chemotherapy Hypersensitivity. J Allergy Clin Immunol Pract. 2020 May; 8(5):1665-1667. Otani IM, Castells M. PMID: 32389278.
      View in: PubMed   Mentions:    Fields:    
    7. Hypogammaglobulinemia in Patients with Neuromyelitis Optica (NMO). Journal of Allergy and Clinical Immunology. 2020 Feb 1; 145(2):ab215. Lulu Tsao, Riley Bove, Tanya Krishnakumar, Iris Otani. .
      View in: Publisher Site   Mentions:
    8. Development of an Antibiotic Allergy Program to Address a Clinical Gap in the Antibiotic Stewardship of Cystic Fibrosis Patients. Journal of Allergy and Clinical Immunology. 2020 Feb 1; 145(2):ab167. Karen Anstey, Mary Ellen Kleinhenz, Iris Otani. .
      View in: Publisher Site   Mentions:
    9. Primary Immunodeficiency Diagnoses seen in Patients with Chronic Lung Disease: Findings from the USIDNET Registry. Journal of Allergy and Clinical Immunology. 2020 Feb 1; 145(2):ab178. Michael Lee, John Routes, Rebecca Marsh, Ramsay Fuleihan, Patricia Lugar, Charlotte Cunningham-Rundles, Elizabeth Garabedian, Iris Otani. .
      View in: Publisher Site   Mentions:
    10. A006 ADVERSE DRUG REACTIONS IN CYSTIC FIBROSIS PATIENTS: USING DATA TO DEVELOP AN ANTIBIOTIC EVALUATION PROGRAM. Annals of Allergy Asthma & Immunology. 2019 Nov 1; 123(5):s4. K. Anstey, M. Kleinhenz, I. Otani. .
      View in: Publisher Site   Mentions:
    11. 2543. Implementation of a Fellow-Driven ?-Lactam Allergy De-Labeling Initiative on an Inpatient ID Consult Service. Open Forum Infectious Diseases. 2019 Oct 23; 6(Supplement_2):s883-s883. Jennifer S Mulliken, Rachel Bystritsky, Karen Anstey, Iris M Otani, Sarah B Doernberg. .
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    12. Beta-lactam Administration Patterns at a Safety-net Hospital with Limited Access to Inpatient Penicillin Skin Testing. Journal of Allergy and Clinical Immunology. 2019 Feb 1; 143(2):ab31. Paula Song, Michael Hwa, Jen Eng, Iris M. Otani. .
      View in: Publisher Site   Mentions:
    13. Perioperative Use and Safety of Cephalosporin Antibiotics in Patients with Documented Penicillin Allergy. Journal of Allergy and Clinical Immunology. 2019 Feb 1; 143(2):ab29. Karen Anstey, James Anstey, Alexandra Hilts-Horeczko, Sarah B. Doernberg, Lee-Lynn Chen, Iris M. Otani. .
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    14. Strategies for Discontinuing Omalizumab in Patients with Chronic Urticaria: Real-World Findings. Journal of Allergy and Clinical Immunology. 2019 Feb 1; 143(2):ab302. Sara Seghezzo, Lulu Tsao, Iris M. Otani. .
      View in: Publisher Site   Mentions:
    15. Hypogammaglobulinemia in Multiple Sclerosis Patients Receiving Disease-Modifying Immunomodulatory Agents. Journal of Allergy and Clinical Immunology. 2019 Feb 1; 143(2):ab16. Lulu Tsao, Iris M. Otani, Riley Bove. .
      View in: Publisher Site   Mentions:
    16. Development of a health-related quality of life instrument for patients with hereditary angioedema living in the United States. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1679-1683.e7. Busse PJ, Christiansen SC, Birmingham JM, Overbey JR, Banerji A, Otani IM, Lumry W, Goryachkovsky A, Zuraw BL. PMID: 30550806.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis. Clin Case Rep. 2018 Sep; 6(9):1834-1840. Otani IM, Carroll RW, Yager P, Kroshinsky D, Murphy S, Hornick JL, Akin C, Castells M, Walter JE. PMID: 30214774.
      View in: PubMed   Mentions:
    18. Cutaneous Manifestations of Reactions to Biologics. Curr Allergy Asthma Rep. 2018 02 21; 18(2):12. Otani IM, Levin AS, Banerji A. PMID: 29464437.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Impact of a Novel Radiocontrast Media Reaction Treatment Algorithm in Simulation Settings of Anaphylaxis. Journal of Allergy and Clinical Immunology. 2018 Feb 1; 141(2):ab34. Iris M. Otani, Alexi Otrakji, Niki Holtzman, Matthew Iandoli, Kimberly G. Blumenthal, Aleena Banerji, Gloria Salazar. .
      View in: Publisher Site   Mentions:
    20. Documentation of Adverse Drug Reactions in Electronic Medical Records: Areas for Improvement and Impact on Clinical Outcomes. Journal of Allergy and Clinical Immunology. 2018 Feb 1; 141(2):ab168. Jenna T. Nguyen, Iris M. Otani. .
      View in: Publisher Site   Mentions:
    21. Chapter 23 Corticosteroids. Drug Allergy Testing. 2018 Jan 1; 261-268. Iris M. Otani. .
      View in: Publisher Site   Mentions:
    22. Utility of Risk Stratification for Paclitaxel Hypersensitivity Reactions. J Allergy Clin Immunol Pract. 2018 Jul - Aug; 6(4):1266-1273.e2. Otani IM, Lax T, Long AA, Slawski BR, Camargo CA, Banerji A. PMID: 28986119.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Platinum Chemotherapy Hypersensitivity: Prevalence and Management. Immunol Allergy Clin North Am. 2017 11; 37(4):663-677. Otani IM, Wong J, Banerji A. PMID: 28965633.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Acquired C1 Inhibitor Deficiency. Immunol Allergy Clin North Am. 2017 08; 37(3):497-511. Otani IM, Banerji A. PMID: 28687105.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2017 05; 37(2):369-396. Otani IM, Nadeau KC. PMID: 28366483.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Gastrointestinal Manifestations in X-linked Agammaglobulinemia. J Clin Immunol. 2017 Apr; 37(3):287-294. Barmettler S, Otani IM, Minhas J, Abraham RS, Chang Y, Dorsey MJ, Ballas ZK, Bonilla FA, Ochs HD, Walter JE. PMID: 28236219.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. Subcutaneous Icatibant for the Treatment of Hereditary Angioedema Attacks: Comparison of Home Self-Administration with Administration at a Medical Facility. J Allergy Clin Immunol Pract. 2017 Mar - Apr; 5(2):442-447.e1. Otani IM, Lumry WR, Hurwitz S, Li HH, Craig TJ, Holtzman NS, Iandoli MI, Tucker J, Riedl MA, Zuraw BL, Banerji A. PMID: 27818136.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Emergency Department Management of Hereditary Angioedema Attacks: Patient Perspectives. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):128-134.e4. Otani IM, Christiansen SC, Busse P, Camargo CA, Zuraw BL, Riedl MA, Banerji A. PMID: 27665386.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):107-113.e1. Levin AS, Otani IM, Lax T, Hochberg E, Banerji A. PMID: 27497683.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Immediate and Delayed Hypersensitivity Reactions to Proton Pump Inhibitors: Evaluation and Management. Curr Allergy Asthma Rep. 2016 Mar; 16(3):17. Otani IM, Banerji A. PMID: 26810177.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    31. Immediate and Delayed Hypersensitivity Reactions to Corticosteroids: Evaluation and Management. Curr Allergy Asthma Rep. 2016 Mar; 16(3):18. Otani IM, Banerji A. PMID: 26857016.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. Subcutaneous Icatibant for the Treatment of Acute Attacks of Hereditary Angioedema: Comparison of Self-Administration to Administration at a Medical Facility. Journal of Allergy and Clinical Immunology. 2016 Feb 1; 137(2):ab250. Iris Otani, William R. Lumry, Huamin Henry Li, Chevy Chase, Timothy J. Craig, Marc A. Riedl, Bruce L. Zuraw, Aleena Banerji. .
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    33. A role for vancomycin epicutaneous skin testing in the evaluation of perioperative anaphylaxis. J Allergy Clin Immunol Pract. 2015 Nov-Dec; 3(6):984-5. Otani IM, Kuhlen JL, Blumenthal KG, Guyer A, Banerji A. PMID: 26246124.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies. Allergy Asthma Clin Immunol. 2014; 10(1):57. Arasi S, Otani IM, Klingbeil E, Bégin P, Kearney C, Dominguez TL, Block WM, O'Riordan G, Nadeau KC. PMID: 25788951.
      View in: PubMed   Mentions:
    35. Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy Asthma Clin Immunol. 2014; 10(1):25. Otani IM, Bégin P, Kearney C, Dominguez TL, Mehrotra A, Bacal LR, Wilson S, Nadeau K. PMID: 24860608.
      View in: PubMed   Mentions:
    36. Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2013 Jun; 131(6):1576-82. Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS. PMID: 23623266.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    37. Multi-Allergen Oral Immunotherapy Improves Quality of Life in Subjects with Food Allergies. Journal of Allergy and Clinical Immunology. 2013 Feb 1; 131(2):ab58. Iris Otani, Tina L.R. Dominguez, Alicia Sciancalepore, Anjuli Mehrotra, Daniela Pineda, Kari Nadeau. .
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    38. The Effect of Anti-IL-5 Therapy on Esophageal Mastocytosis in Pediatric Eosinophilic Esophagitis. Journal of Allergy and Clinical Immunology. 2012 Feb 1; 129(2):ab202. I.M. Otani, M. Bhagat, R.O. Newbury, R. Dohil, D.H. Broide, S.S. Aceves. .
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    39. Monomeric IgE and mast cell development, survival and function. Adv Exp Med Biol. 2011; 716:29-46. Kashiwakura J, Otani IM, Kawakami T. PMID: 21713650.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    40. A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohort. Genet Med. 2007 Jul; 9(7):413-26. Putcha GV, Bejjani BA, Bleoo S, Booker JK, Carey JC, Carson N, Das S, Dempsey MA, Gastier-Foster JM, Greinwald JH, Hoffmann ML, Jeng LJ, Kenna MA, Khababa I, Lilley M, Mao R, Muralidharan K, Otani IM, Rehm HL, Schaefer F, Seltzer WK, Spector EB, Springer MA, Weck KE, Wenstrup RJ, Withrow S, Wu BL, Zariwala MA, Schrijver I. PMID: 17666888.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
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