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Mary Ellen Kleinhenz, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of PennsylvaniaM.D.1975School of Medicine
    Collapse Awards and Honors
    CWRU Department of Medicine1980Elton Hoyt II Research Prize
    The Hartford Foundation1982  - 1986The John A. and George L. Hartford Medical Fellowship
    American College of Chest Physicians1986Fellow
    NHLBI Division of Lung Disease1987Pulmonary Academic Award
    UCSF Division of Pulmonary, Critical Care, Allergy and Sleep Medicine2012Michael Stulbarg Outstanding Teaching Award

    Collapse Overview 
    Collapse Overview
    Dr. Kleinhenz is a Professor of Medicine in the UCSF Department of Medicine, Division of Pulmonary, Critical Care, Allergy-Immunology and Sleep Medicine. She is the Director of the UCSF Adult Cystic Fibrosis Program and Associate Director of the UCSF Cystic Fibrosis Center. Dr. Kleinhenz is also a Transplant Physician of the UCSF Lung Transplant Program.

    Dr. Kleinhenz's clinical interests include adult cystic fibrosis, bronchiectasis due to conditions other than cystic fibrosis, pulmonary disease from non-tuberculous mycobacteria and lung transplantation. She maintains an active consultative practice in the UCSF Pulmonary Practice at Parnassus.

    Dr. Kleinhenz long-term commitment to adult cystic fibrosis care and management. She is a member of the Center Committee of the Cystic Fibrosis Foundation and participates in the Foundation's Quality Assurance Program. She has championed the training of clinicians in adult cystic fibrosis care; several of her former trainees now staff and direct Adult Cystic Fibrosis Programs across the Nation. Dr. Kleinhenz has directed several trials of potential therapies for cystic fibrosis at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Center Grant to the UCSF Adult CF Program
    Cystic Fibrosis Foundation Jul 1, 2019 - Jun 30, 2020
    Role: Principal Investigator
    Role Description: This funding is renewed annually and provides support for the work to understand and improve care for people living with cystic fibrosis.
    Cystic Fibrosis Lung Transplant Transitions Learning Leadership Collaborative 2
    Cystic Fibrosis Foundation May 1, 2019 - Oct 31, 2020
    Role: Principal Investigator, UCSF Adult CF Team
    Role Description: This is a multi center quality improvement collaborative. I lead the UCSF Adult CF Team in developing a coherent approach to the management of patients with advanced CF lung disease with particular focus on preparation lung transplant evaluation.

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020 Apr 01; 130(4):2041-2053. PMID: 31961827.
      View in: PubMed
    2. Perez AA, Hays SR, Soong A, Gao Y, Greenland JR, Leard LE, Shah RJ, Golden J, Kukreja J, Venado A, Kleinhenz ME, Singer JP. Improvements in frailty contribute to substantial improvements in quality of life after lung transplantation in patients with cystic fibrosis. Pediatr Pulmonol. 2020 Apr 01. PMID: 32237273.
      View in: PubMed
    3. Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR. Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction. Am J Respir Cell Mol Biol. 2020 Mar; 62(3):364-372. PMID: 31647878.
      View in: PubMed
    4. Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, Blanc PD, Singer JP. Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients. Am J Health Syst Pharm. 2019 12 02; 76(24):2019-2027. PMID: 31696925.
      View in: PubMed
    5. Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR. Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: A single center experience. Transpl Infect Dis. 2019 Jun; 21(3):e13084. PMID: 30924986.
      View in: PubMed
    6. Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD. Gene signatures common to allograft rejection are associated with lymphocytic bronchitis. Clin Transplant. 2019 05; 33(5):e13515. PMID: 30849195.
      View in: PubMed
    7. Venado A, McCulloch C, Greenland JR, Katz P, Soong A, Shrestha P, Hays S, Golden J, Shah R, Leard LE, Kleinhenz ME, Kukreja J, Zablotska L, Allen IE, Covinsky K, Blanc P, Singer JP. Frailty trajectories in adult lung transplantation: A cohort study. J Heart Lung Transplant. 2019 Jul; 38(7):699-707. PMID: 31005571.
      View in: PubMed
    8. Kolaitis NA, Soong A, Shrestha P, Zhuo H, Neuhaus J, Katz PP, Greenland JR, Golden J, Leard LE, Shah RJ, Hays SR, Kukreja J, Kleinhenz ME, Blanc PD, Singer JP. Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation. J Thorac Cardiovasc Surg. 2018 07; 156(1):440-448.e2. PMID: 29550072.
      View in: PubMed
    9. Kerkhoff AD, Patrick L, Cornett P, Kleinhenz ME, Brondfield S. Severe piperacillin-tazobactam-induced hemolysis in a cystic fibrosis patient. Clin Case Rep. 2017 12; 5(12):2059-2061. PMID: 29225856.
      View in: PubMed
    10. Singer JP, Katz PP, Soong A, Shrestha P, Huang D, Ho J, Mindo M, Greenland JR, Hays SR, Golden J, Kukreja J, Kleinhenz ME, Shah RJ, Blanc PD. Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study. Am J Transplant. 2017 May; 17(5):1334-1345. PMID: 27743488.
      View in: PubMed
    11. Okumura MJ, Kleinhenz ME. Cystic Fibrosis Transitions of Care: Lessons Learned and Future Directions for Cystic Fibrosis. Clin Chest Med. 2016 Mar; 37(1):119-26. PMID: 26857773.
      View in: PubMed
    12. Tokman S, Hays SR, Leard LE, Bush EL, Kukreja J, Kleinhenz ME, Golden JA, Singer JP. Prolonged Barium-Impaction Ileus in Two Lung Transplant Recipients With Systemic Sclerosis: Case Report. Transplant Proc. 2015 Dec; 47(10):2965-7. PMID: 26707322.
      View in: PubMed
    13. Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP. The feasibility of lung transplantation in HIV-seropositive patients. Ann Am Thorac Soc. 2014 Jul; 11(6):882-9. PMID: 24964265.
      View in: PubMed
    14. Okumura MJ, Ong T, Dawson D, Nielson D, Lewis N, Richards M, Brindis CD, Kleinhenz ME. Improving transition from paediatric to adult cystic fibrosis care: programme implementation and evaluation. BMJ Qual Saf. 2014 Apr; 23 Suppl 1:i64-i72. PMID: 24415776.
      View in: PubMed
    15. Cox MJ, Allgaier M, Taylor B, Baek MS, Huang YJ, Daly RA, Karaoz U, Andersen GL, Brown R, Fujimura KE, Wu B, Tran D, Koff J, Kleinhenz ME, Nielson D, Brodie EL, Lynch SV. Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients. PLoS One. 2010 Jun 23; 5(6):e11044. PMID: 20585638.
      View in: PubMed
    16. Webb EM, Kleinhenz ME, Coakley FV, Chang CI, Westphalen AC, Yeh BM. Colonic wall redundancy at CT in patients with cystic fibrosis. Radiology. 2008 Sep; 248(3):869-75. PMID: 18647844.
      View in: PubMed
    17. Gasper WJ, Sweet MP, Golden JA, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Patti MG. Lung transplantation in patients with connective tissue disorders and esophageal dysmotility. Dis Esophagus. 2008; 21(7):650-5. PMID: 18459990.
      View in: PubMed
    18. Gasper WJ, Sweet MP, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Golden JA, Patti MG. Antireflux surgery for patients with end-stage lung disease before and after lung transplantation. Surg Endosc. 2008 Feb; 22(2):495-500. PMID: 17704875.
      View in: PubMed
    19. Espiritu JD, Ruppel G, Shrestha Y, Kleinhenz ME. The diffusing capacity in adult cystic fibrosis. Respir Med. 2003 Jun; 97(6):606-11. PMID: 12814143.
      View in: PubMed
    20. Kleinhenz ME, Lewis CY. Chronic ventilator dependence in elderly patients. Clin Geriatr Med. 2000 Nov; 16(4):735-56. PMID: 10984753.
      View in: PubMed
    21. Espiritu JD, Kleinhenz ME. Paradoxical embolization in an adult patient with cystic fibrosis. Mayo Clin Proc. 2000 Oct; 75(10):1100-2. PMID: 11040860.
      View in: PubMed
    22. Goodnough LT, Kleinhenz ME, Goldsmith GH, Ziats NP, Robertson AL. Bovine aortic endothelial cells elaborate an inhibitor of the generation of lipopolysaccharide-stimulated human blood monocyte procoagulant activity. J Clin Invest. 1984 Jul; 74(1):75-81. PMID: 6736253.
      View in: PubMed
    23. Ellner JJ, Olds GR, Lee CW, Kleinhenz ME, Edmonds KL. Destruction of the multicellular parasite Schistosoma mansoni by T lymphocytes. J Clin Invest. 1982 Aug; 70(2):369-78. PMID: 6980229.
      View in: PubMed
    24. Kleinhenz ME, Ellner JJ, Spagnuolo PJ, Daniel TM. Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan. Monocyte dependence and indomethacin reversibility. J Clin Invest. 1981 Jul; 68(1):153-62. PMID: 6972952.
      View in: PubMed