Mary Ellen Kleinhenz, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of PennsylvaniaM.D.1975School of Medicine
    Collapse Awards and Honors
    CWRU Department of Medicine1980Elton Hoyt II Research Prize
    The Hartford Foundation1982  - 1986The John A. and George L. Hartford Medical Fellowship
    American College of Chest Physicians1986Fellow
    NHLBI Division of Lung Disease1987Pulmonary Academic Award
    UCSF Division of Pulmonary, Critical Care, Allergy and Sleep Medicine2012Michael Stulbarg Outstanding Teaching Award

    Collapse Overview 
    Collapse Overview
    Dr. Kleinhenz is a Professor of Medicine in the UCSF Department of Medicine, Division of Pulmonary, Critical Care, Allergy-Immunology and Sleep Medicine. She is the Director of the UCSF Adult Cystic Fibrosis Program and Associate Director of the UCSF Cystic Fibrosis Center. Dr. Kleinhenz is also a Transplant Physician of the UCSF Lung Transplant Program.

    Dr. Kleinhenz's clinical interests include adult cystic fibrosis, bronchiectasis due to conditions other than cystic fibrosis, pulmonary disease from non-tuberculous mycobacteria and lung transplantation. She maintains an active consultative practice in the UCSF Pulmonary Practice at Parnassus.

    Dr. Kleinhenz long-term commitment to adult cystic fibrosis care and management. She is a member of the Center Committee of the Cystic Fibrosis Foundation and participates in the Foundation's Quality Assurance Program. She has championed the training of clinicians in adult cystic fibrosis care; several of her former trainees now staff and direct Adult Cystic Fibrosis Programs across the Nation. Dr. Kleinhenz has directed several trials of potential therapies for cystic fibrosis at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Center Grant to the UCSF Adult CF Program
    Cystic Fibrosis Foundation Jul 1, 2019 - Jun 30, 2020
    Role: Principal Investigator
    Description: This funding is renewed annually and provides support for the work to understand and improve care for people living with cystic fibrosis.
    Cystic Fibrosis Lung Transplant Transitions Learning Leadership Collaborative 2
    Cystic Fibrosis Foundation May 1, 2019 - Oct 31, 2020
    Role: Principal Investigator, UCSF Adult CF Team
    Description: This is a multi center quality improvement collaborative. I lead the UCSF Adult CF Team in developing a coherent approach to the management of patients with advanced CF lung disease with particular focus on preparation lung transplant evaluation.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Small airway brush gene expression predicts chronic lung allograft dysfunction and mortality. J Heart Lung Transplant. 2024 Jul 24. Mohanty RP, Moghbeli K, Singer JP, Calabrese DR, Hays SR, Iasella C, Lieber S, Leard LE, Shah RJ, Venado A, Kleinhenz ME, Golden JA, Martinu T, Love C, Ward R, Langelier CR, McDyer J, Greenland JR. PMID: 39115489.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI Insight. 2023 Nov 08; 8(21). Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden JA, Leard L, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR. PMID: 37788115; PMCID: PMC10721259.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis. Transplant Direct. 2023 Sep; 9(9):e1495. Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR. PMID: 37575951; PMCID: PMC10414707.
      View in: PubMed   Mentions: 1  
    4. Development of the Lung Transplant Frailty Scale (LT-FS). J Heart Lung Transplant. 2023 07; 42(7):892-904. Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Zaleski D, Adler J, Kalman L, Balar P, Patel S, Medikonda N, Koons B, Tevald M, Covinsky KE, Greenland JR, Katz PK. PMID: 36925382; PMCID: PMC11022684.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Subphenotypes of frailty in lung transplant candidates. Am J Transplant. 2023 04; 23(4):531-539. Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Brown M, Zaleski D, Medikonda N, Kalman L, Balar P, Patel S, Calabrese DR, Greenland JR, Christie JD. PMID: 36740192; PMCID: PMC11005295.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function. J Heart Lung Transplant. 2023 06; 42(6):828-837. Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein AB, Singer JP, Hays SR. PMID: 37031033.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022 12 22; 7(24). Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. PMID: 36346670; PMCID: PMC9869973.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    8. Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction. Thorax. 2022 09; 77(9):891-899. Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden JA, Venado A, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Kukreja J, Blanc PD, Smith PJ, Singer JP. PMID: 35354643.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction. Front Immunol. 2021; 12:704172. Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR. PMID: 34691018; PMCID: PMC8528961.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    10. Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Ann Am Thorac Soc. 2021 09; 18(9):1464-1474. Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP. PMID: 33565917; PMCID: PMC8489868.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    11. Enabling antibiotic allergy evaluations and reintroduction of first-line antibiotics for patients with cystic fibrosis. Ann Allergy Asthma Immunol. 2021 10; 127(4):456-461. Anstey KM, Choi L, Dawson D, Kleinhenz ME, Otani IM. PMID: 34048884.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation. Clin Transplant. 2021 05; 35(5):e14275. DeBolt CL, Gao Y, Sutter N, Soong A, Leard L, Jeffrey G, Kleinhenz ME, Calabrese D, Greenland J, Venado A, Hays SR, Shah R, Kukreja J, Trinh B, Kolaitis NA, Douglas V, Diamond JM, Smith P, Singer J. PMID: 33682171; PMCID: PMC11098451.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature. Am J Transplant. 2021 01; 21(1):362-371. Dugger DT, Fung M, Hays SR, Singer JP, Kleinhenz ME, Leard LE, Golden JA, Shah RJ, Lee JS, Deiter F, Greenland NY, Jones KD, Langelier CR, Greenland JR. PMID: 32885581; PMCID: PMC8009189.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    14. Primary graft dysfunction attenuates improvements in health-related quality of life after lung transplantation, but not disability or depression. Am J Transplant. 2021 02; 21(2):815-824. Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden J, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Venado A, Kukreja J, Blanc PD, Singer JP. PMID: 32794295.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection. Cell Rep Med. 2020 07 21; 1(4). Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR. PMID: 32754722; PMCID: PMC7402593.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. Antibiotic adverse reactions in adult cystic fibrosis patients. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3631-3633.e1. Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM. PMID: 32673878.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Improvements in frailty contribute to substantial improvements in quality of life after lung transplantation in patients with cystic fibrosis. Pediatr Pulmonol. 2020 06; 55(6):1406-1413. Perez AA, Hays SR, Soong A, Gao Y, Greenland JR, Leard LE, Shah RJ, Golden J, Kukreja J, Venado A, Kleinhenz ME, Singer JP. PMID: 32237273; PMCID: PMC8048765.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020 04 01; 130(4):2041-2053. Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. PMID: 31961827; PMCID: PMC7108932.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    19. Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction. Am J Respir Cell Mol Biol. 2020 03; 62(3):364-372. Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR. PMID: 31647878; PMCID: PMC7055700.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    20. Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients. Am J Health Syst Pharm. 2019 12 02; 76(24):2019-2027. Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, Blanc PD, Singer JP. PMID: 31696925; PMCID: PMC7170730.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: A single center experience. Transpl Infect Dis. 2019 Jun; 21(3):e13084. Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR. PMID: 30924986.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Gene signatures common to allograft rejection are associated with lymphocytic bronchitis. Clin Transplant. 2019 05; 33(5):e13515. Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD. PMID: 30849195; PMCID: PMC6545574.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Frailty trajectories in adult lung transplantation: A cohort study. J Heart Lung Transplant. 2019 07; 38(7):699-707. Venado A, McCulloch C, Greenland JR, Katz P, Soong A, Shrestha P, Hays S, Golden J, Shah R, Leard LE, Kleinhenz ME, Kukreja J, Zablotska L, Allen IE, Covinsky K, Blanc P, Singer JP. PMID: 31005571; PMCID: PMC6612595.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    24. Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation. J Thorac Cardiovasc Surg. 2018 07; 156(1):440-448.e2. Kolaitis NA, Soong A, Shrestha P, Zhuo H, Neuhaus J, Katz PP, Greenland JR, Golden J, Leard LE, Shah RJ, Hays SR, Kukreja J, Kleinhenz ME, Blanc PD, Singer JP. PMID: 29550072; PMCID: PMC6013366.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Severe piperacillin-tazobactam-induced hemolysis in a cystic fibrosis patient. Clin Case Rep. 2017 12; 5(12):2059-2061. Kerkhoff AD, Patrick L, Cornett P, Kleinhenz ME, Brondfield S. PMID: 29225856; PMCID: PMC5715418.
      View in: PubMed   Mentions: 3  
    26. Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study. Am J Transplant. 2017 May; 17(5):1334-1345. Singer JP, Katz PP, Soong A, Shrestha P, Huang D, Ho J, Mindo M, Greenland JR, Hays SR, Golden J, Kukreja J, Kleinhenz ME, Shah RJ, Blanc PD. PMID: 27743488; PMCID: PMC6085872.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    27. Cystic Fibrosis Transitions of Care: Lessons Learned and Future Directions for Cystic Fibrosis. Clin Chest Med. 2016 Mar; 37(1):119-26. Okumura MJ, Kleinhenz ME. PMID: 26857773.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Prolonged Barium-Impaction Ileus in Two Lung Transplant Recipients With Systemic Sclerosis: Case Report. Transplant Proc. 2015 Dec; 47(10):2965-7. Tokman S, Hays SR, Leard LE, Bush EL, Kukreja J, Kleinhenz ME, Golden JA, Singer JP. PMID: 26707322.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. The feasibility of lung transplantation in HIV-seropositive patients. Ann Am Thorac Soc. 2014 Jul; 11(6):882-9. Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP. PMID: 24964265; PMCID: PMC4213997.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    30. Improving transition from paediatric to adult cystic fibrosis care: programme implementation and evaluation. BMJ Qual Saf. 2014 Apr; 23 Suppl 1:i64-i72. Okumura MJ, Ong T, Dawson D, Nielson D, Lewis N, Richards M, Brindis CD, Kleinhenz ME. PMID: 24415776; PMCID: PMC4449274.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    31. Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients. PLoS One. 2010 Jun 23; 5(6):e11044. Cox MJ, Allgaier M, Taylor B, Baek MS, Huang YJ, Daly RA, Karaoz U, Andersen GL, Brown R, Fujimura KE, Wu B, Tran D, Koff J, Kleinhenz ME, Nielson D, Brodie EL, Lynch SV. PMID: 20585638; PMCID: PMC2890402.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansCells
    32. Colonic wall redundancy at CT in patients with cystic fibrosis. Radiology. 2008 Sep; 248(3):869-75. Webb EM, Kleinhenz ME, Coakley FV, Chang CI, Westphalen AC, Yeh BM. PMID: 18647844.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Lung transplantation in patients with connective tissue disorders and esophageal dysmotility. Dis Esophagus. 2008; 21(7):650-5. Gasper WJ, Sweet MP, Golden JA, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Patti MG. PMID: 18459990.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    34. Antireflux surgery for patients with end-stage lung disease before and after lung transplantation. Surg Endosc. 2008 Feb; 22(2):495-500. Gasper WJ, Sweet MP, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Golden JA, Patti MG. PMID: 17704875.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    35. The diffusing capacity in adult cystic fibrosis. Respir Med. 2003 Jun; 97(6):606-11. Espiritu JD, Ruppel G, Shrestha Y, Kleinhenz ME. PMID: 12814143.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Chronic ventilator dependence in elderly patients. Clin Geriatr Med. 2000 Nov; 16(4):735-56. Kleinhenz ME, Lewis CY. PMID: 10984753.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Paradoxical embolization in an adult patient with cystic fibrosis. Mayo Clin Proc. 2000 Oct; 75(10):1100-2. Espiritu JD, Kleinhenz ME. PMID: 11040860.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    38. Bovine aortic endothelial cells elaborate an inhibitor of the generation of lipopolysaccharide-stimulated human blood monocyte procoagulant activity. J Clin Invest. 1984 Jul; 74(1):75-81. Goodnough LT, Kleinhenz ME, Goldsmith GH, Ziats NP, Robertson AL. PMID: 6736253; PMCID: PMC425186.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    39. Destruction of the multicellular parasite Schistosoma mansoni by T lymphocytes. J Clin Invest. 1982 Aug; 70(2):369-78. Ellner JJ, Olds GR, Lee CW, Kleinhenz ME, Edmonds KL. PMID: 6980229; PMCID: PMC371245.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    40. Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan. Monocyte dependence and indomethacin reversibility. J Clin Invest. 1981 Jul; 68(1):153-62. Kleinhenz ME, Ellner JJ, Spagnuolo PJ, Daniel TM. PMID: 6972952; PMCID: PMC370783.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
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