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Mary Ellen Kleinhenz, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address400 Parnassus Avenue
San Francisco CA 94117
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    Collapse Biography 
    Collapse Education and Training
    University of PennsylvaniaM.D.1975School of Medicine
    Collapse Awards and Honors
    CWRU Department of Medicine1980Elton Hoyt II Research Prize
    The Hartford Foundation1982  - 1986The John A. and George L. Hartford Medical Fellowship
    American College of Chest Physicians1986Fellow
    NHLBI Division of Lung Disease1987Pulmonary Academic Award
    UCSF Division of Pulmonary, Critical Care, Allergy and Sleep Medicine2012Michael Stulbarg Outstanding Teaching Award

    Collapse Overview 
    Collapse Overview
    Dr. Kleinhenz is a Professor of Medicine in the UCSF Department of Medicine, Division of Pulmonary, Critical Care, Allergy-Immunology and Sleep Medicine. She is the Director of the UCSF Adult Cystic Fibrosis Program and Associate Director of the UCSF Cystic Fibrosis Center. Dr. Kleinhenz is also a Transplant Physician of the UCSF Lung Transplant Program.

    Dr. Kleinhenz's clinical interests include adult cystic fibrosis, bronchiectasis due to conditions other than cystic fibrosis, pulmonary disease from non-tuberculous mycobacteria and lung transplantation. She maintains an active consultative practice in the UCSF Pulmonary Practice at Parnassus.

    Dr. Kleinhenz long-term commitment to adult cystic fibrosis care and management. She is a member of the Center Committee of the Cystic Fibrosis Foundation and participates in the Foundation's Quality Assurance Program. She has championed the training of clinicians in adult cystic fibrosis care; several of her former trainees now staff and direct Adult Cystic Fibrosis Programs across the Nation. Dr. Kleinhenz has directed several trials of potential therapies for cystic fibrosis at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Center Grant to the UCSF Adult CF Program
    Cystic Fibrosis Foundation Jul 1, 2019 - Jun 30, 2020
    Role: Principal Investigator
    Role Description: This funding is renewed annually and provides support for the work to understand and improve care for people living with cystic fibrosis.
    Cystic Fibrosis Lung Transplant Transitions Learning Leadership Collaborative 2
    Cystic Fibrosis Foundation May 1, 2019 - Oct 31, 2020
    Role: Principal Investigator, UCSF Adult CF Team
    Role Description: This is a multi center quality improvement collaborative. I lead the UCSF Adult CF Team in developing a coherent approach to the management of patients with advanced CF lung disease with particular focus on preparation lung transplant evaluation.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Antibiotic Adverse Reactions in Adult Cystic Fibrosis Patients. J Allergy Clin Immunol Pract. 2020 Jul 13. Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM. PMID: 32673878.
      View in: PubMed   Mentions:    Fields:    
    2. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020 Apr 01; 130(4):2041-2053. Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. PMID: 31961827.
      View in: PubMed   Mentions:    Fields:    
    3. Improvements in frailty contribute to substantial improvements in quality of life after lung transplantation in patients with cystic fibrosis. Pediatr Pulmonol. 2020 Jun; 55(6):1406-1413. Perez AA, Hays SR, Soong A, Gao Y, Greenland JR, Leard LE, Shah RJ, Golden J, Kukreja J, Venado A, Kleinhenz ME, Singer JP. PMID: 32237273.
      View in: PubMed   Mentions:    Fields:    
    4. Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction. Am J Respir Cell Mol Biol. 2020 Mar; 62(3):364-372. Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR. PMID: 31647878.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients. Am J Health Syst Pharm. 2019 12 02; 76(24):2019-2027. Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, Blanc PD, Singer JP. PMID: 31696925.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: A single center experience. Transpl Infect Dis. 2019 Jun; 21(3):e13084. Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR. PMID: 30924986.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Gene signatures common to allograft rejection are associated with lymphocytic bronchitis. Clin Transplant. 2019 05; 33(5):e13515. Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD. PMID: 30849195.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Frailty trajectories in adult lung transplantation: A cohort study. J Heart Lung Transplant. 2019 07; 38(7):699-707. Venado A, McCulloch C, Greenland JR, Katz P, Soong A, Shrestha P, Hays S, Golden J, Shah R, Leard LE, Kleinhenz ME, Kukreja J, Zablotska L, Allen IE, Covinsky K, Blanc P, Singer JP. PMID: 31005571.
      View in: PubMed   Mentions:    Fields:    
    9. Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation. J Thorac Cardiovasc Surg. 2018 07; 156(1):440-448.e2. Kolaitis NA, Soong A, Shrestha P, Zhuo H, Neuhaus J, Katz PP, Greenland JR, Golden J, Leard LE, Shah RJ, Hays SR, Kukreja J, Kleinhenz ME, Blanc PD, Singer JP. PMID: 29550072.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Severe piperacillin-tazobactam-induced hemolysis in a cystic fibrosis patient. Clin Case Rep. 2017 12; 5(12):2059-2061. Kerkhoff AD, Patrick L, Cornett P, Kleinhenz ME, Brondfield S. PMID: 29225856.
      View in: PubMed   Mentions:
    11. Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study. Am J Transplant. 2017 May; 17(5):1334-1345. Singer JP, Katz PP, Soong A, Shrestha P, Huang D, Ho J, Mindo M, Greenland JR, Hays SR, Golden J, Kukreja J, Kleinhenz ME, Shah RJ, Blanc PD. PMID: 27743488.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    12. Cystic Fibrosis Transitions of Care: Lessons Learned and Future Directions for Cystic Fibrosis. Clin Chest Med. 2016 Mar; 37(1):119-26. Okumura MJ, Kleinhenz ME. PMID: 26857773.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Prolonged Barium-Impaction Ileus in Two Lung Transplant Recipients With Systemic Sclerosis: Case Report. Transplant Proc. 2015 Dec; 47(10):2965-7. Tokman S, Hays SR, Leard LE, Bush EL, Kukreja J, Kleinhenz ME, Golden JA, Singer JP. PMID: 26707322.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. The feasibility of lung transplantation in HIV-seropositive patients. Ann Am Thorac Soc. 2014 Jul; 11(6):882-9. Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP. PMID: 24964265.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Improving transition from paediatric to adult cystic fibrosis care: programme implementation and evaluation. BMJ Qual Saf. 2014 Apr; 23 Suppl 1:i64-i72. Okumura MJ, Ong T, Dawson D, Nielson D, Lewis N, Richards M, Brindis CD, Kleinhenz ME. PMID: 24415776.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    16. Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients. PLoS One. 2010 Jun 23; 5(6):e11044. Cox MJ, Allgaier M, Taylor B, Baek MS, Huang YJ, Daly RA, Karaoz U, Andersen GL, Brown R, Fujimura KE, Wu B, Tran D, Koff J, Kleinhenz ME, Nielson D, Brodie EL, Lynch SV. PMID: 20585638.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansCells
    17. Colonic wall redundancy at CT in patients with cystic fibrosis. Radiology. 2008 Sep; 248(3):869-75. Webb EM, Kleinhenz ME, Coakley FV, Chang CI, Westphalen AC, Yeh BM. PMID: 18647844.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Lung transplantation in patients with connective tissue disorders and esophageal dysmotility. Dis Esophagus. 2008; 21(7):650-5. Gasper WJ, Sweet MP, Golden JA, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Patti MG. PMID: 18459990.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    19. Antireflux surgery for patients with end-stage lung disease before and after lung transplantation. Surg Endosc. 2008 Feb; 22(2):495-500. Gasper WJ, Sweet MP, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Golden JA, Patti MG. PMID: 17704875.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    20. The diffusing capacity in adult cystic fibrosis. Respir Med. 2003 Jun; 97(6):606-11. Espiritu JD, Ruppel G, Shrestha Y, Kleinhenz ME. PMID: 12814143.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Chronic ventilator dependence in elderly patients. Clin Geriatr Med. 2000 Nov; 16(4):735-56. Kleinhenz ME, Lewis CY. PMID: 10984753.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Paradoxical embolization in an adult patient with cystic fibrosis. Mayo Clin Proc. 2000 Oct; 75(10):1100-2. Espiritu JD, Kleinhenz ME. PMID: 11040860.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    23. Bovine aortic endothelial cells elaborate an inhibitor of the generation of lipopolysaccharide-stimulated human blood monocyte procoagulant activity. J Clin Invest. 1984 Jul; 74(1):75-81. Goodnough LT, Kleinhenz ME, Goldsmith GH, Ziats NP, Robertson AL. PMID: 6736253.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Destruction of the multicellular parasite Schistosoma mansoni by T lymphocytes. J Clin Invest. 1982 Aug; 70(2):369-78. Ellner JJ, Olds GR, Lee CW, Kleinhenz ME, Edmonds KL. PMID: 6980229.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan. Monocyte dependence and indomethacin reversibility. J Clin Invest. 1981 Jul; 68(1):153-62. Kleinhenz ME, Ellner JJ, Spagnuolo PJ, Daniel TM. PMID: 6972952.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
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