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Optical control of sphingolipid biosynthesis using photoswitchable sphingosines. J Lipid Res. 2024 Dec 11; 100724.
Kol M, Novak AJE, Morstein J, Schröer C, Sokoya T, Mensing S, Korneev SM, Trauner D, Holthuis JCM. PMID: 39672331.
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PubMed Mentions: Fields:
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Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis. Glia. 2024 Nov 03.
Amatruda M, Marechal D, Gacias M, Wentling M, Turpin-Nolan S, Morstein J, Moniruzzaman M, Brüning JC, Haughey NJ, Trauner DH, Casaccia P. PMID: 39489703.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Optical control of sphingolipid biosynthesis using photoswitchable sphingosines. bioRxiv. 2024 Oct 24.
Kol M, Novak AJE, Morstein J, Schröer C, Sokoya T, Mensing S, Korneev SM, Trauner D, Holthuis JCM. PMID: 39484495; PMCID: PMC11527141.
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PubMed Mentions:
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Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist. Proc Natl Acad Sci U S A. 2024 Oct; 121(40):e2404243121.
Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R. PMID: 39331410; PMCID: PMC11459184.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell. 2024 Oct 31; 187(22):6379-6392.e17.
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM. PMID: 39255801; PMCID: PMC11531380.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Optical Control of Proteasomal Protein Degradation with a Photoswitchable Lipopeptide. Angew Chem Int Ed Engl. 2024 02 19; 63(8):e202314791.
Morstein J, Amatuni A, Shuster A, Kuttenlochner W, Ko T, Abegg D, Groll M, Adibekian A, Renata H, Trauner DH. PMID: 38109686.
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PubMed Mentions: Fields:
Translation:
Cells
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Selective activation of intracellular β1AR using a spatially restricted antagonist. bioRxiv. 2023 Nov 22.
Liccardo F, Morstein J, Lin TY, Pampel J, Shokat KM, Irannejad R. PMID: 38045405; PMCID: PMC10690298.
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PubMed Mentions:
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Direct Modulators of K-Ras-Membrane Interactions. ACS Chem Biol. 2023 09 15; 18(9):2082-2093.
Morstein J, Shrestha R, Van QN, López CA, Arora N, Tonelli M, Liang H, Zhou Y, Hancock JF, Stephen AG, Turbyville TJ, Shokat KM. PMID: 37579045; PMCID: PMC10510109.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Development of Light-Activated LXR Agonists. ChemMedChem. 2023 06 01; 18(11):e202200647.
Mukhopadhyay TK, Willems S, Arp CJ, Morstein J, Haake CT, Merk D, Trauner D. PMID: 36896647.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes. Nat Biomed Eng. 2023 03; 7(3):313-322.
Simon J, Schwalm M, Morstein J, Trauner D, Jasanoff A. PMID: 36550300; PMCID: PMC11232483.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Optical Control of Translation with a Puromycin Photoswitch. J Am Chem Soc. 2022 11 30; 144(47):21494-21501.
Ko T, Oliveira MM, Alapin JM, Morstein J, Klann E, Trauner D. PMID: 36394560; PMCID: PMC11302736.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation. ACS Chem Biol. 2022 10 21; 17(10):2945-2953.
Morstein J, Bader T, Cardillo AL, Schackmann J, Ashok S, Hougland JL, Hrycyna CA, Trauner DH, Distefano MD. PMID: 36194691; PMCID: PMC9799063.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity. J Am Chem Soc. 2022 10 12; 144(40):18532-18544.
Morstein J, Capecchi A, Hinnah K, Park B, Petit-Jacques J, Van Lehn RC, Reymond JL, Trauner D. PMID: 36178375.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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Postsynthetic Photocontrol of Giant Liposomes via Fusion-Based Photolipid Doping. Langmuir. 2022 10 04; 38(39):11941-11949.
Pritzl SD, Morstein J, Kahler S, Konrad DB, Trauner D, Lohmüller T. PMID: 36130117; PMCID: PMC9536078.
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PubMed Mentions:
1 Fields:
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Optical control of neuronal activities with photoswitchable nanovesicles. Nano Res. 2023 Jan; 16(1):1033-1041.
Xiong H, Alberto KA, Youn J, Taura J, Morstein J, Li X, Wang Y, Trauner D, Slesinger PA, Nielsen SO, Qin Z. PMID: 37063114; PMCID: PMC10103898.
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PubMed Mentions:
3
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Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. J Am Chem Soc. 2022 09 07; 144(35):15916-15921.
Zhang Z, Morstein J, Ecker AK, Guiley KZ, Shokat KM. PMID: 36001446; PMCID: PMC9460778.
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PubMed Mentions:
44 Fields:
Translation:
Humans
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Photopharmacological control of cell signaling with photoswitchable lipids. Curr Opin Pharmacol. 2022 04; 63:102202.
Mukhopadhyay TK, Morstein J, Trauner D. PMID: 35278838.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor. Angew Chem Int Ed Engl. 2022 04 25; 61(18):e202117094.
Morstein J, Romano G, Hetzler BE, Plante A, Haake C, Levitz J, Trauner D. PMID: 34989082; PMCID: PMC9423688.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Optical Control of Glycerolipids and Sphingolipids. Chimia (Aarau). 2021 Dec 22; 75(12):1022-1025.
Trauner D, Morstein J. PMID: 34920771.
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PubMed Mentions:
1 Fields:
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Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages. J Biol Chem. 2021 12; 297(6):101411.
Bryan AM, You JK, Li G, Kim J, Singh A, Morstein J, Trauner D, Pereira de Sá N, Normile TG, Farnoud AM, London E, Del Poeta M. PMID: 34793834; PMCID: PMC8661020.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Optical Control of Phosphatidic Acid Signaling. ACS Cent Sci. 2021 Jul 28; 7(7):1205-1215.
Tei R, Morstein J, Shemet A, Trauner D, Baskin JM. PMID: 34345670; PMCID: PMC8323247.
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PubMed Mentions:
9
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A Photohormone for Light-Dependent Control of PPARα in Live Cells. J Med Chem. 2021 07 22; 64(14):10393-10402.
Willems S, Morstein J, Hinnah K, Trauner D, Merk D. PMID: 34213899.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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How Photoswitchable Lipids Affect the Order and Dynamics of Lipid Bilayers and Embedded Proteins. J Am Chem Soc. 2021 Jun 16.
Doroudgar M, Morstein J, Becker-Baldus J, Trauner D, Glaubitz C. PMID: 34133158.
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PubMed Mentions:
16 Fields:
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Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release. Small. 2021 05; 17(21):e2008198.
Chander N, Morstein J, Bolten JS, Shemet A, Cullis PR, Trauner D, Witzigmann D. PMID: 33880882.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. Gastroenterology. 2021 07; 161(1):301-317.e16.
Chen Y, Wang ZL, Yeo M, Zhang QJ, López-Romero AE, Ding HP, Zhang X, Zeng Q, Morales-Lázaro SL, Moore C, Jin YA, Yang HH, Morstein J, Bortsov A, Krawczyk M, Lammert F, Abdelmalek M, Diehl AM, Milkiewicz P, Kremer AE, Zhang JY, Nackley A, Reeves TE, Ko MC, Ji RR, Rosenbaum T, Liedtke W. PMID: 33819485; PMCID: PMC9093619.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Short Photoswitchable Ceramides Enable Optical Control of Apoptosis. ACS Chem Biol. 2021 03 19; 16(3):452-456.
Morstein J, Kol M, Novak AJE, Feng S, Khayyo S, Hinnah K, Li-Purcell N, Pan G, Williams BM, Riezman H, Atilla-Gokcumen GE, Holthuis JCM, Trauner D. PMID: 33586946.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Evolutionarily related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion. Proc Natl Acad Sci U S A. 2021 01 05; 118(1).
Chan KMC, Arthur AL, Morstein J, Jin M, Bhat A, Schlesinger D, Son S, Stevens DA, Drubin DG, Fletcher DA. PMID: 33443166; PMCID: PMC7817207.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Photoswitchable Lipids. Chembiochem. 2021 01 05; 22(1):73-83.
Morstein J, Impastato AC, Trauner D. PMID: 32790211.
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PubMed Mentions:
29 Fields:
Translation:
Cells
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Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25818-25829.
Wang X, Liu H, Morstein J, Novak AJE, Trauner D, Xiong Q, Yu Y, Ge S. PMID: 32973092; PMCID: PMC7568294.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ). J Med Chem. 2020 10 08; 63(19):10908-10920.
Hinnah K, Willems S, Morstein J, Heering J, Hartrampf FWW, Broichhagen J, Leippe P, Merk D, Trauner D. PMID: 32886507.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes That Enable Endogenous Carbon Monoxide Detection. J Am Chem Soc. 2020 09 16; 142(37):15917-15930.
Morstein J, Höfler D, Ueno K, Jurss JW, Walvoord RR, Bruemmer KJ, Rezgui SP, Brewer TF, Saitoe M, Michel BW, Chang CJ. PMID: 32872768.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Optical Control of Lysophosphatidic Acid Signaling. J Am Chem Soc. 2020 06 17; 142(24):10612-10616.
Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank JA, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D. PMID: 32469525; PMCID: PMC7920854.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Photopharmacological control of lipid function. Methods Enzymol. 2020; 638:219-232.
Morstein J, Trauner D. PMID: 32416914.
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PubMed Mentions:
2 Fields:
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A Photoswitchable Inhibitor of the Human Serotonin Transporter. ACS Chem Neurosci. 2020 05 06; 11(9):1231-1237.
Cheng B, Morstein J, Ladefoged LK, Maesen JB, Schiøtt B, Sinning S, Trauner D. PMID: 32275382; PMCID: PMC8022892.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamine Release. J Neurosci. 2020 04 29; 40(18):3533-3548.
Ueno K, Morstein J, Ofusa K, Naganos S, Suzuki-Sawano E, Minegishi S, Rezgui SP, Kitagishi H, Michel BW, Chang CJ, Horiuchi J, Saitoe M. PMID: 32253360; PMCID: PMC7189754.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Optical control of the nuclear bile acid receptor FXR with a photohormone. Chem Sci. 2020 Jan 14; 11(2):429-434.
Morstein J, Trads JB, Hinnah K, Willems S, Barber DM, Trauner M, Merk D, Trauner D. PMID: 32190263; PMCID: PMC7067245.
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PubMed Mentions:
5
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Fixing a Photosensitizer Unlocks and Localizes Its Lethality. ACS Cent Sci. 2019 Oct 23; 5(10):1636-1638.
Trauner D, Morstein J. PMID: 31660430; PMCID: PMC6813549.
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PubMed Mentions:
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New players in phototherapy: photopharmacology and bio-integrated optoelectronics. Curr Opin Chem Biol. 2019 06; 50:145-151.
Morstein J, Trauner D. PMID: 31108317.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Optical control of sphingosine-1-phosphate formation and function. Nat Chem Biol. 2019 06; 15(6):623-631.
Morstein J, Hill RZ, Novak AJE, Feng S, Norman DD, Donthamsetti PC, Frank JA, Harayama T, Williams BM, Parrill AL, Tigyi GJ, Riezman H, Isacoff EY, Bautista DM, Trauner D. PMID: 31036923; PMCID: PMC7428055.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course. EBioMedicine. 2019 May; 43:392-410.
Castro K, Ntranos A, Amatruda M, Petracca M, Kosa P, Chen EY, Morstein J, Trauner D, Watson CT, Kiebish MA, Bielekova B, Inglese M, Katz Sand I, Casaccia P. PMID: 30981648; PMCID: PMC6557766.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Mapping the Azolog Space Enables the Optical Control of New Biological Targets. ACS Cent Sci. 2019 Apr 24; 5(4):607-618.
Morstein J, Awale M, Reymond JL, Trauner D. PMID: 31041380; PMCID: PMC6487453.
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PubMed Mentions:
28
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In Vivo Photopharmacology. Chem Rev. 2018 11 14; 118(21):10710-10747.
Hüll K, Morstein J, Trauner D. PMID: 29985590.
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PubMed Mentions:
259 Fields:
Translation:
HumansAnimalsCells
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Total Synthesis of (±)-Exotine B. Org Lett. 2018 07 20; 20(14):4358-4361.
Cheng B, Volpin G, Morstein J, Trauner D. PMID: 29978703; PMCID: PMC6056846.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Correction to "Copper-Mediated C-N Coupling of Arylsilanes with Nitrogen Nucleophiles". Org Lett. 2016 12 02; 18(23):6216.
Morstein J, Kalkman ED, Bold C, Cheng C, Hartwig JF. PMID: 27934346; PMCID: PMC9033264.
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PubMed Mentions: Fields:
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Copper-Mediated C-N Coupling of Arylsilanes with Nitrogen Nucleophiles. Org Lett. 2016 10 21; 18(20):5244-5247.
Morstein J, Kalkman ED, Bold C, Cheng C, Hartwig JF. PMID: 27689746; PMCID: PMC5809131.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Trifluoromethylation of Arylsilanes with [(phen)CuCF3 ]. Angew Chem Int Ed Engl. 2016 07 04; 55(28):8054-7.
Morstein J, Hou H, Cheng C, Hartwig JF. PMID: 27214849; PMCID: PMC4976628.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
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The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations. EMBO Mol Med. 2016 05; 8(5):442-57.
Diederichs S, Bartsch L, Berkmann JC, Fröse K, Heitmann J, Hoppe C, Iggena D, Jazmati D, Karschnia P, Linsenmeier M, Maulhardt T, Möhrmann L, Morstein J, Paffenholz SV, Röpenack P, Rückert T, Sandig L, Schell M, Steinmann A, Voss G, Wasmuth J, Weinberger ME, Wullenkord R. PMID: 26992833; PMCID: PMC5126213.
View in:
PubMed Mentions:
141 Fields:
Translation:
HumansAnimalsCells