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Roshanak Irannejad, PhD

Title(s)Assistant Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Awards and Honors
    NIH-NHLBI2014  - 2020NIH Pathway to Independence Award (K99/R00)
    American Heart Association2012  - 2014Postdotoral Fellowship
    American Heart Association2008  - 2010Predoctoral Fellowship

    Collapse Research 
    Collapse Research Activities and Funding
    INVESTIGATION OF A NEWLY DISCOVERED ORGANELLE-BASED SIGNALING PARADIGM
    NIH/NIGMS R35GM133521Sep 1, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Role of endocytosis in beta-adrenergic receptors signaling in cardiomyocytes
    NIH/NHLBI R00HL122508Feb 2, 2017 - Jan 31, 2020
    Role: Principal Investigator
    Role of endocytosis in beta-adrenergic receptors signaling in cardiomyocytes
    NIH/NHLBI K99HL122508Apr 4, 2014 - Feb 29, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. G protein-regulated endocytic trafficking of adenylyl cyclase type 9. Elife. 2020 Jun 09; 9. Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M. PMID: 32515353.
      View in: PubMed   Mentions:    Fields:    
    2. Emerging Role of Compartmentalized G Protein-Coupled Receptor Signaling in the Cardiovascular Field. ACS Pharmacol Transl Sci. 2020 Apr 10; 3(2):221-236. Plouffe B, Thomsen ARB, Irannejad R. PMID: 32296764.
      View in: PubMed   Mentions:
    3. Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PLoS Genet. 2019 09; 15(9):e1008208. Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM. PMID: 31553721.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Golgi localized ß1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCe to regulate cardiac hypertrophy. Elife. 2019 08 21; 8. Nash CA, Wei W, Irannejad R, Smrcka AV. PMID: 31433293.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    5. Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles. J Am Chem Soc. 2018 09 05; 140(35):11058-11066. Fu C, Kobayashi T, Wang N, Hoppmann C, Yang B, Irannejad R, Wang L. PMID: 30132658.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Functional selectivity of GPCR-directed drug action through location bias. Nat Chem Biol. 2017 Jul; 13(7):799-806. Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M. PMID: 28553949.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    7. Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs. Curr Biol. 2016 12 05; 26(23):3129-3142. Varandas KC, Irannejad R, von Zastrow M. PMID: 27839977.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    8. The a-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor. J Biol Chem. 2016 Jul 08; 291(28):14510-25. Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. PMID: 27226565.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. Effects of endocytosis on receptor-mediated signaling. Curr Opin Cell Biol. 2015 Aug; 35:137-43. Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M. PMID: 26057614.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    10. G protein ß? subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway. Mol Biol Cell. 2015 Mar 15; 26(6):1188-98. Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. PMID: 25609085.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem. 2015 Mar 13; 290(11):6689-96. Tsvetanova NG, Irannejad R, von Zastrow M. PMID: 25605726.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    12. Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol. 2014; 535:403-18. Irannejad R, Kotowski SJ, von Zastrow M. PMID: 24377936.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. GPCR signaling along the endocytic pathway. Curr Opin Cell Biol. 2014 Apr; 27:109-16. Irannejad R, von Zastrow M. PMID: 24680436.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    14. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013 Mar 28; 495(7442):534-8. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. PMID: 23515162.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansCells
    15. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits. J Biol Chem. 2010 Oct 15; 285(42):32393-404. Irannejad R, Wedegaertner PB. PMID: 20720014.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    16. Assembly and trafficking of heterotrimeric G proteins. Biochemistry. 2007 Jul 03; 46(26):7665-77. Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. PMID: 17559193.
      View in: PubMed   Mentions: 85     Fields:    Translation:Cells
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