Roshanak Irannejad, PhD

Title(s)Associate Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-8702-2285 Additional info
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    Collapse Biography 
    Collapse awards and honors
    American Society for Pharmacology and Experimental Therapeutics-Division of Molecular Pharmacology2023Early Career Award
    NIH-NHLBI2014  - 2020NIH Pathway to Independence Award (K99/R00)
    American Heart Association2012  - 2014Postdotoral Fellowship
    American Heart Association2008  - 2010Predoctoral Fellowship

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    INVESTIGATION OF A NEWLY DISCOVERED ORGANELLE-BASED SIGNALING PARADIGM
    NIH/NIGMS R35GM133521Sep 1, 2019 - Jun 30, 2029
    Role: Principal Investigator
    Role of endocytosis in beta-adrenergic receptors signaling in cardiomyocytes
    NIH/NHLBI R00HL122508Feb 2, 2017 - Jan 31, 2020
    Role: Principal Investigator
    Role of endocytosis in beta-adrenergic receptors signaling in cardiomyocytes
    NIH K99HL122508Apr 4, 2014 - Jan 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist. Proc Natl Acad Sci U S A. 2024 Oct; 121(40):e2404243121. Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R. PMID: 39331410; PMCID: PMC11459184.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. cAMP signaling: a remarkably regional affair. Trends Biochem Sci. 2024 Apr; 49(4):305-317. Bock A, Irannejad R, Scott JD. PMID: 38310024; PMCID: PMC11175624.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    3. Selective activation of intracellular β1AR using a spatially restricted antagonist. bioRxiv. 2023 Nov 22. Liccardo F, Morstein J, Lin TY, Pampel J, Shokat KM, Irannejad R. PMID: 38045405; PMCID: PMC10690298.
      View in: PubMed   Mentions:
    4. Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools. Nat Chem Biol. 2024 01; 20(1):62-73. Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R. PMID: 37474759; PMCID: PMC10746541.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    5. The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus. Elife. 2022 04 25; 11. Puri NM, Romano GR, Lin TY, Mai QN, Irannejad R. PMID: 35467530; PMCID: PMC9098220.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    6. G protein-regulated endocytic trafficking of adenylyl cyclase type 9. Elife. 2020 06 09; 9. Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M. PMID: 32515353; PMCID: PMC7332294.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    7. Emerging Role of Compartmentalized G Protein-Coupled Receptor Signaling in the Cardiovascular Field. ACS Pharmacol Transl Sci. 2020 Apr 10; 3(2):221-236. Plouffe B, Thomsen ARB, Irannejad R. PMID: 32296764; PMCID: PMC7155194.
      View in: PubMed   Mentions: 19  
    8. Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PLoS Genet. 2019 09; 15(9):e1008208. Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM. PMID: 31553721; PMCID: PMC6760779.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    9. Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife. 2019 08 21; 8. Nash CA, Wei W, Irannejad R, Smrcka AV. PMID: 31433293; PMCID: PMC6726460.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    10. Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles. J Am Chem Soc. 2018 09 05; 140(35):11058-11066. Fu C, Kobayashi T, Wang N, Hoppmann C, Yang B, Irannejad R, Wang L. PMID: 30132658; PMCID: PMC6145950.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    11. Functional selectivity of GPCR-directed drug action through location bias. Nat Chem Biol. 2017 Jul; 13(7):799-806. Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M. PMID: 28553949; PMCID: PMC5733145.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    12. Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs. Curr Biol. 2016 12 05; 26(23):3129-3142. Varandas KC, Irannejad R, von Zastrow M. PMID: 27839977; PMCID: PMC5140749.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    13. The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor. J Biol Chem. 2016 Jul 08; 291(28):14510-25. Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. PMID: 27226565; PMCID: PMC4938174.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    14. Effects of endocytosis on receptor-mediated signaling. Curr Opin Cell Biol. 2015 Aug; 35:137-43. Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M. PMID: 26057614; PMCID: PMC4529812.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    15. G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway. Mol Biol Cell. 2015 Mar 15; 26(6):1188-98. Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. PMID: 25609085; PMCID: PMC4357516.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    16. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem. 2015 Mar 13; 290(11):6689-96. Tsvetanova NG, Irannejad R, von Zastrow M. PMID: 25605726; PMCID: PMC4358092.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    17. Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol. 2014; 535:403-18. Irannejad R, Kotowski SJ, von Zastrow M. PMID: 24377936; PMCID: PMC4023871.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. GPCR signaling along the endocytic pathway. Curr Opin Cell Biol. 2014 Apr; 27:109-16. Irannejad R, von Zastrow M. PMID: 24680436; PMCID: PMC4968408.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    19. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013 Mar 28; 495(7442):534-8. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. PMID: 23515162; PMCID: PMC3835555.
      View in: PubMed   Mentions: 363     Fields:    Translation:HumansCells
    20. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits. J Biol Chem. 2010 Oct 15; 285(42):32393-404. Irannejad R, Wedegaertner PB. PMID: 20720014; PMCID: PMC2952241.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    21. Assembly and trafficking of heterotrimeric G proteins. Biochemistry. 2007 Jul 03; 46(26):7665-77. Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. PMID: 17559193; PMCID: PMC2527407.
      View in: PubMed   Mentions: 87     Fields:    
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