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John Teerlink, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
AddressVAMC 203
San Francisco CA 94121
Phone415-221-4810 ext. 24160
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    Collapse Biography 
    Collapse Education and Training
    Swarthmore CollegeBA with Highest Honors1983
    Harvard Medical SchoolM.D.1988
    University of California, San FranciscoResidency 1991School of Medicine
    F. Hoffmann-La Roche, LTD (Basel, SwitzerlandPost-Doctoral Fellowship1993Cardiovascular Pharmacology
    University of California, San Francisco Clinical Cardiology Fellowship 1995Internal Medicine

    Collapse Overview 
    Collapse Overview
    Dr. John R. Teerlink, F.A.C.C., F.A.H.A., F.E.S.C., F.R.C.P.(London) is Director of the Heart Failure Program and of the Clinical Echocardiography Laboratory at the San Francisco Veterans Affairs Medical Center in San Francisco, California. He graduated from Swarthmore College with Highest Honors in Comparative Religious Studies and Cellular Biology. After receiving his medical degree from Harvard Medical School, where he performed a year of research in the laboratory of Drs. Janice and Marc Pfeffer, he completed an internal medicine residency at the University of California San Francisco (UCSF). He continued his basic science training through a post-doctoral research fellowship at Hoffman-LaRoche in Basel, Switzerland with Drs. Martine and Jean-Paul Clozel. Dr. Teerlink completed his cardiovascular medicine fellowship and a Howard Hughes post-doctoral research fellowship at UCSF, subsequently joining the faculty, where he currently is a Professor of Medicine.

    He is actively involved in the design and execution of many acute and chronic heart failure clinical trials, serving on endpoint, data safety monitoring, and steering committees for numerous international studies investigating a variety of new therapies, including tezosentan (RITZ program, VERITAS), levosimendan (REVIVE), nesiritide (ASCEND-HF), relaxin (Pre-RELAX-AHF, RELAX-AHF), rolofylline (PROTECT), omecamtiv mecarbil (CY1111, CY1121, ATOMIC-AHF), warfarin/ aspirin (WARCEF), and LCZ696 (PARADIGM-HF).

    Dr. Teerlink has been an active member of the Heart Failure Society of America, serving on multiple committees including the Membership, Scientific Program, and Guideline Committees, and is a founding member of the American Association of Heart Failure Nurses. He has also served on the National Committee on Heart Failure and Transplantation of the American Heart Association. Dr. Teerlink completed a four-year term as a permanent member of the United States Food and Drug Administration (FDA) Cardiovascular and Renal Drugs Advisory Committee, and currently serves as an ad hoc member of other FDA advisory committees and panels. He is a member of the joint FDA/ Duke University Standardized Data Collection for Cardiovascular Clinical Trials Initiative to develop standardized definitions for cardiovascular endpoints. He was an Associate Editor for the Journal of Cardiac Failure and is a clinical scholar presenting many lectures and publications, including a chapter on Acute Heart Failure in Braunwald’s Heart Disease textbook.


    Collapse Research 
    Collapse Research Activities and Funding
    STANDUP-AHF: Evaluate the Safety and Efficacy of 48-Hour Infusions of HNO (Nitroxyl) Donor in Hospitalized Patients With Heart Failure
    Bristol-Myers Squibb Mar 1, 2016
    Role: Steering Committee Member
    GALACTIC-HF: Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure
    Amgen/ Cytokinetics/ Servier Nov 1, 2015
    Role: Trial Principal Investigator; Executive Committee Chairperson
    FIGARO-DKD: FInerenone in reducinG cArdiovascular moRtality and mOrbidity in Diabetic Kidney Disease
    Bayer Nov 1, 2015
    Role: Clinical Events Committee Member
    FIDELIO-DKD: FInerenone in reducing kiDnEy faiLure and dIsease prOgression in Diabetic Kidney Disease
    Bayer Nov 1, 2015
    Role: Clinical Events Committee Member
    CardioMEMS PAS: CardioMEMS HF System Post Approval Study
    St. Jude/ Abbott Apr 1, 2015
    Role: Clinical Events Committee Member
    ADAPT-Response: AdaptResponse Clinical Trial
    Medtronic Jul 1, 2014
    Role: Clinical Events Committee Member
    BLAST-AHF: Biased Ligand of the Angiotensin II Type 1 Receptor in Patients with Acute Heart Failure
    Trevena, Inc Aug 1, 2013
    Role: Steering Committee Member
    RELAX-REPEAT
    Novartis May 1, 2013
    Role: Trial Principal Investigator
    RELAX-AHF-Asia: Evaluating the Efficacy, Safety, and Tolerability of Serelaxin when Added to Standard Therapy in Asian Patients with Acute Heart Failure
    Novartis Apr 1, 2013
    Role: Steering Committee Member
    RELAX-AHF-2: Serelaxin in addition to standard therapy in acute heart failure
    Novartis Sep 1, 2012
    Role: Trial Co-Principal Investigator/ Executive Committee Co-Chairperson
    COSMIC-HF: Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure
    Amgen/ Cytokinetics Sep 1, 2012
    Role: Trial Principal Investigator; Executive Committee Chairperson
    CHART: Congestive Heart failure Cardiopoietic Regenerative Therapy
    Celyad Jul 1, 2012
    Role: Clinical Events Committee Chairperson; Publication Committee Member
    PARADIGM-HF: A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality in Patients With Chronic Heart Failure and Reduced Ejection Fraction
    Novartis May 15, 2010
    Role: Co-US National Leader
    LAPTOP-HF: Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy Study
    St. Jude Apr 1, 2010 - Dec 31, 2015
    Role: Clinical Events Committee Member

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cotter G, Metra M, Davison BA, Jondeau G, Cleland JGF, Bourge RC, Milo O, O'Connor CM, Parker JD, Torre-Amione G, van Veldhuisen DJ, Kobrin I, Rainisio M, Senger S, Edwards C, McMurray JJV, Teerlink J. Systolic blood pressure reduction during the first 24?h in acute heart failure admission: friend or foe? Eur J Heart Fail. 2017 Sep 04. PMID: 28871621.
      View in: PubMed
    2. Pang PS, Butler J, Collins SP, Cotter G, Davison BA, Ezekowitz JA, Filippatos G, Levy PD, Metra M, Ponikowski P, Teerlink J, Voors AA, Bharucha D, Goin K, Soergel DG, Felker GM. Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure: a randomized, double-blind, placebo-controlled, phase IIB, dose ranging trial (BLAST-AHF). Eur Heart J. 2017 Aug 07; 38(30):2364-2373. PMID: 28459958.
      View in: PubMed
    3. Teerlink J, Qian M, Bello NA, Freudenberger RS, Levin B, Di Tullio MR, Graham S, Mann DL, Sacco RL, Mohr JP, Lip GYH, Labovitz AJ, Lee SC, Ponikowski P, Lok DJ, Anker SD, Thompson JLP, Homma S. Aspirin Does Not Increase Heart Failure Events in Heart Failure Patients: From the WARCEF Trial. JACC Heart Fail. 2017 Aug; 5(8):603-610. PMID: 28774396.
      View in: PubMed
    4. Filippatos G, Farmakis D, Metra M, Cotter G, Davison BA, Felker GM, Greenberg BH, Hua TA, Pang PS, Ponikowski P, Qian M, Severin TA, Voors AA, Teerlink J. Erratum to: Serelaxin in acute heart failure patients with and without atrial fibrillation: a secondary analysis of the RELAX-AHF trial. Clin Res Cardiol. 2017 Jul 27. PMID: 28752374.
      View in: PubMed
    5. Greene SJ, Hernandez AF, Dunning A, Ambrosy AP, Armstrong PW, Butler J, Cerbin LP, Coles A, Ezekowitz JA, Metra M, Starling RC, Teerlink J, Voors AA, O'Connor CM, Mentz RJ. Hospitalization for Recently Diagnosed Versus Worsening Chronic Heart Failure: From the ASCEND-HF Trial. J Am Coll Cardiol. 2017 Jun 27; 69(25):3029-3039. PMID: 28641792.
      View in: PubMed
    6. Liu LCY, Valente MAE, Postmus D, O'Connor CM, Metra M, Dittrich HC, Ponikowski P, Teerlink J, Cotter G, Davison B, Cleland JGF, Givertz MM, Bloomfield DM, van Veldhuisen DJ, Hillege HL, van der Meer P, Voors AA. Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial : Differential Response in Acute Heart Failure. Cardiovasc Drugs Ther. 2017 Jun 27. PMID: 28656542.
      View in: PubMed
    7. Sharma A, Demissei BG, Tromp J, Hillege HL, Cleland JG, O'Connor CM, Metra M, Ponikowski P, Teerlink J, Davison BA, Givertz MM, Bloomfield DM, Dittrich H, van Veldhuisen DJ, Cotter G, Ezekowitz JA, Khan MAF, Voors AA. A network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure. Eur J Heart Fail. 2017 Jun 21. PMID: 28639369.
      View in: PubMed
    8. Tromp J, Khan MAF, Mentz RJ, O'Connor CM, Metra M, Dittrich HC, Ponikowski P, Teerlink J, Cotter G, Davison B, Cleland JGF, Givertz MM, Bloomfield DM, Van Veldhuisen DJ, Hillege HL, Voors AA, van der Meer P. Biomarker Profiles of Acute Heart Failure Patients With a Mid-Range Ejection Fraction. JACC Heart Fail. 2017 Jul; 5(7):507-517. PMID: 28624483.
      View in: PubMed
    9. Teerlink J, Metra M, Filippatos GS, Davison BA, Bartunek J, Terzic A, Gersh BJ, Povsic TJ, Henry TD, Alexandre B, Homsy C, Edwards C, Seron A, Wijns W, Cotter G. Benefit of cardiopoietic mesenchymal stem cell therapy on left ventricular remodelling: results from the Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) study. Eur J Heart Fail. 2017 May 31. PMID: 28560782.
      View in: PubMed
    10. Gimpelewicz C, Metra M, Cleland JGF, Szecsödy P, Chang Wun CC, Boer-Martins L, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Pang P, Ponikowski P, Severin T, Voors AA, Teerlink J. Effects of serelaxin on the outcome of patients with or without substantial peripheral edema: A subgroup analysis from the RELAX-AHF trial. Am Heart J. 2017 Aug; 190:113-122. PMID: 28760204.
      View in: PubMed
    11. Teerlink J, Voors AA, Ponikowski P, Pang PS, Greenberg BH, Filippatos G, Felker GM, Davison BA, Cotter G, Gimpelewicz C, Boer-Martins L, Wernsing M, Hua TA, Severin T, Metra M. Serelaxin in addition to standard therapy in acute heart failure: rationale and design of the RELAX-AHF-2 study. Eur J Heart Fail. 2017 Jun; 19(6):800-809. PMID: 28452195.
      View in: PubMed
    12. Butler J, Hamo CE, Udelson JE, O'Connor C, Sabbah HN, Metra M, Shah SJ, Kitzman DW, Teerlink J, Bernstein HS, Brooks G, Depre C, DeSouza MM, Dinh W, Donovan M, Frische-Danielson R, Frost RJ, Garza D, Gohring UM, Hellawell J, Hsia J, Ishihara S, Kay-Mugford P, Koglin J, Kozinn M, Larson CJ, Mayo M, Gan LM, Mugnier P, Mushonga S, Roessig L, Russo C, Salsali A, Satler C, Shi V, Ticho B, van der Laan M, Yancy C, Stockbridge N, Gheorghiade M. Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations. Circ Heart Fail. 2017 Apr; 10(4). PMID: 28356300.
      View in: PubMed
    13. Cleland JGF, Teerlink J, Davison BA, Shoaib A, Metra M, Senger S, Milo O, Cotter G, Bourge RC, Parker JD, Jondeau G, Krum H, O'Connor CM, Torre-Amione G, van Veldhuisen DJ, McMurray JJV. Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure-does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS). Eur J Heart Fail. 2017 Jun; 19(6):739-747. PMID: 28296139.
      View in: PubMed
    14. Demissei BG, Postmus D, Cleland JG, O'Connor CM, Metra M, Ponikowski P, Teerlink J, Cotter G, Davison BA, Givertz MM, Bloomfield DM, van Veldhuisen DJ, Dittrich HC, Hillege HL, Voors AA. Plasma biomarkers to predict or rule out early post-discharge events after hospitalization for acute heart failure. Eur J Heart Fail. 2017 Jun; 19(6):728-738. PMID: 28251755.
      View in: PubMed
    15. Bartunek J, Terzic A, Davison BA, Filippatos GS, Radovanovic S, Beleslin B, Merkely B, Musialek P, Wojakowski W, Andreka P, Horvath IG, Katz A, Dolatabadi D, El Nakadi B, Arandjelovic A, Edes I, Seferovic PM, Obradovic S, Vanderheyden M, Jagic N, Petrov I, Atar S, Halabi M, Gelev VL, Shochat MK, Kasprzak JD, Sanz-Ruiz R, Heyndrickx GR, Nyolczas N, Legrand V, Guédès A, Heyse A, Moccetti T, Fernandez-Aviles F, Jimenez-Quevedo P, Bayes-Genis A, Hernandez-Garcia JM, Ribichini F, Gruchala M, Waldman SA, Teerlink J, Gersh BJ, Povsic TJ, Henry TD, Metra M, Hajjar RJ, Tendera M, Behfar A, Alexandre B, Seron A, Stough WG, Sherman W, Cotter G, Wijns W. Cardiopoietic cell therapy for advanced ischaemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial. Eur Heart J. 2017 Mar 01; 38(9):648-660. PMID: 28025189.
      View in: PubMed
    16. Pang PS, Teerlink J, Boer-Martins L, Gimpelewicz C, Davison BA, Wang Y, Voors AA, Severin T, Ponikowski P, Hua TA, Greenberg BH, Filippatos G, Felker GM, Cotter G, Metra M. Day vs night: Does time of presentation matter in acute heart failure? A secondary analysis from the RELAX-AHF trial. Am Heart J. 2017 May; 187:62-69. PMID: 28454809.
      View in: PubMed
    17. Singh A, Laribi S, Teerlink J, Mebazaa A. Agents with vasodilator properties in acute heart failure. Eur Heart J. 2017 02 01; 38(5):317-325. PMID: 28201723.
      View in: PubMed
    18. Tyler JM, Teerlink J. The safety of sacubitril-valsartan for the treatment of chronic heart failure. Expert Opin Drug Saf. 2017 Feb; 16(2):257-263. PMID: 28060547.
      View in: PubMed
    19. Streng KW, Ter Maaten JM, Cleland JG, O'Connor CM, Davison BA, Metra M, Givertz MM, Teerlink J, Ponikowski P, Bloomfield DM, Dittrich HC, Hillege HL, van Veldhuisen DJ, Voors AA, van der Meer P. Associations of Body Mass Index With Laboratory and Biomarkers in Patients With Acute Heart Failure. Circ Heart Fail. 2017 Jan; 10(1). PMID: 28069685.
      View in: PubMed
    20. Ambrosy AP, Cerbin LP, Armstrong PW, Butler J, Coles A, DeVore AD, Dunlap ME, Ezekowitz JA, Felker GM, Fudim M, Greene SJ, Hernandez AF, O'Connor CM, Schulte P, Starling RC, Teerlink J, Voors AA, Mentz RJ. Body Weight Change During and After Hospitalization for Acute Heart Failure: Patient Characteristics, Markers of Congestion, and Outcomes: Findings From the ASCEND-HF Trial. JACC Heart Fail. 2017 Jan; 5(1):1-13. PMID: 28034373.
      View in: PubMed
    21. Psotka MA, Teerlink J. Direct Myosin Activation by Omecamtiv Mecarbil for Heart Failure with Reduced Ejection Fraction. Handb Exp Pharmacol. 2017; 243:465-490. PMID: 28315072.
      View in: PubMed
    22. Teerlink J, Felker GM, McMurray JJ, Solomon SD, Adams KF, Cleland JG, Ezekowitz JA, Goudev A, Macdonald P, Metra M, Mitrovic V, Ponikowski P, Serpytis P, Spinar J, Tomcsányi J, Vandekerckhove HJ, Voors AA, Monsalvo ML, Johnston J, Malik FI, Honarpour N. Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial. Lancet. 2016 12 10; 388(10062):2895-2903. PMID: 27914656.
      View in: PubMed
    23. Meyer S, Teerlink J, Metra M, Ponikowski P, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Hua TA, Severin T, Qian M, Voors AA. Sex differences in early dyspnea relief between men and women hospitalized for acute heart failure: insights from the RELAX-AHF study. Clin Res Cardiol. 2017 Apr; 106(4):280-292. PMID: 27838739.
      View in: PubMed
    24. Sato N, Lam CS, Teerlink J, Greenberg BH, Tsutsui H, Oh BH, Zhang J, Lefkowitz M, Hua TA, Holbro T, Marshood M, Wang XL, Ge J. Evaluating the Efficacy, Safety, and Tolerability of Serelaxin When Added to Standard Therapy in Asian Patients With Acute Heart Failure: Design and Rationale of RELAX-AHF-ASIA Trial. J Card Fail. 2017 Jan; 23(1):63-71. PMID: 27825893.
      View in: PubMed
    25. Tromp J, Ter Maaten J, Damman K, O'Connor CM, Metra M, Dittrich HC, Ponikowski P, Teerlink J, Cotter G, Davison B, Cleland JG, Givertz MM, Bloomfield DM, van der Wal MH, Jaarsma T, van Veldhuisen DJ, Hillege HL, Voors AA, van der Meer P. Serum Potassium Levels and Outcome in Acute Heart Failure (Data from the PROTECT and COACH Trials). Am J Cardiol. 2017 Jan 15; 119(2):290-296. PMID: 27823598.
      View in: PubMed
    26. Matsue Y, Ter Maaten JM, Struck J, Metra M, O'Connor CM, Ponikowski P, Teerlink J, Cotter G, Davison B, Cleland JG, Givertz MM, Bloomfield DM, Dittrich HC, van Veldhuisen DJ, van der Meer P, Damman K, Voors AA. Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure. J Card Fail. 2017 Mar; 23(3):231-239. PMID: 27663098.
      View in: PubMed
    27. Wiklund I, Anatchkova M, Oko-Osi H, von Maltzahn R, Chau D, Malik FI, Patrick DL, Spertus J, Teerlink J. Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program. Health Qual Life Outcomes. 2016 Sep 15; 14(1):131. PMID: 27629389.
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    28. Vegter EL, Schmitter D, Hagemeijer Y, Ovchinnikova ES, van der Harst P, Teerlink J, O'Connor CM, Metra M, Davison BA, Bloomfield D, Cotter G, Cleland JG, Givertz MM, Ponikowski P, van Veldhuisen DJ, van der Meer P, Berezikov E, Voors AA, Khan MA. Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure. Int J Cardiol. 2016 Dec 01; 224:231-239. PMID: 27661412.
      View in: PubMed
    29. Greene SJ, Hernandez AF, Sun JL, Metra M, Butler J, Ambrosy AP, Ezekowitz JA, Starling RC, Teerlink J, Schulte PJ, Voors AA, Armstrong PW, O'Connor CM, Mentz RJ. Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure). Circ Heart Fail. 2016 Sep; 9(9). PMID: 27623769.
      View in: PubMed
    30. Demissei BG, Postmus D, Liu LC, Cleland JG, O'Connor CM, Metra M, Ponikowski P, Teerlink J, Cotter G, Davison BA, Edwards C, Givertz MM, Bloomfield DM, Dittrich HC, Voors AA, Hillege HL. Risk-based evaluation of efficacy of rolofylline in patients hospitalized with acute heart failure - Post-hoc analysis of the PROTECT trial. Int J Cardiol. 2016 Nov 15; 223:967-975. PMID: 27589047.
      View in: PubMed
    31. Collins SP, Levy PD, Martindale JL, Dunlap ME, Storrow AB, Pang PS, Albert NM, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hollander JE, Lanfear DE, Lenihan DJ, Lindenfeld JM, Peacock WF, Sawyer DB, Teerlink J, Butler J. Clinical and Research Considerations for Patients With Hypertensive Acute Heart Failure: A Consensus Statement from the Society for Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group. Acad Emerg Med. 2016 Aug; 23(8):922-31. PMID: 27286136.
      View in: PubMed
    32. Ter Maaten JM, Damman K, Hanberg JS, Givertz MM, Metra M, O'Connor CM, Teerlink J, Ponikowski P, Cotter G, Davison B, Cleland JG, Bloomfield DM, Hillege HL, van Veldhuisen DJ, Voors AA, Testani JM. Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure. Circ Heart Fail. 2016 Aug; 9(8). PMID: 27507112.
      View in: PubMed
    33. Ye S, Qian M, Zhao B, Buchsbaum R, Sacco RL, Levin B, Di Tullio MR, Mann DL, Pullicino PM, Freudenberger RS, Teerlink J, Mohr JP, Graham S, Labovitz AJ, Estol CJ, Lok DJ, Ponikowski P, Anker SD, Lip GY, Thompson JL, Homma S. CHA2 DS2 -VASc score and adverse outcomes in patients with heart failure with reduced ejection fraction and sinus rhythm. Eur J Heart Fail. 2016 Oct; 18(10):1261-1266. PMID: 27444219.
      View in: PubMed
    34. Desai AS, Claggett BL, Packer M, Zile MR, Rouleau JL, Swedberg K, Shi V, Lefkowitz M, Starling R, Teerlink J, McMurray JJ, Solomon SD. Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization. J Am Coll Cardiol. 2016 Jul 19; 68(3):241-248. PMID: 27417000.
      View in: PubMed
    35. Psotka MA, von Maltzahn R, Anatchkova M, Agodoa I, Chau D, Malik FI, Patrick DL, Spertus JA, Wiklund I, Teerlink J. Patient-Reported Outcomes in Chronic Heart Failure: Applicability for Regulatory Approval. JACC Heart Fail. 2016 Oct; 4(10):791-804. PMID: 27395351.
      View in: PubMed
    36. Tromp J, Meyer S, Mentz RJ, O'Connor CM, Metra M, Dittrich HC, Ponikowski P, Teerlink J, Cotter G, Davison B, Cleland JG, Givertz MM, Bloomfield DM, van Veldhuisen DJ, Hillege HL, Voors AA, van der Meer P. Acute heart failure in the young: Clinical characteristics and biomarker profiles. Int J Cardiol. 2016 Oct 15; 221:1067-72. PMID: 27448534.
      View in: PubMed
    37. Di Tullio MR, Qian M, Thompson JL, Labovitz AJ, Mann DL, Sacco RL, Pullicino PM, Freudenberger RS, Teerlink J, Graham S, Lip GY, Levin B, Mohr JP, Buchsbaum R, Estol CJ, Lok DJ, Ponikowski P, Anker SD, Homma S. Left Ventricular Ejection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Ejection Fraction Trial. Stroke. 2016 Aug; 47(8):2031-7. PMID: 27354224; PMCID: PMC4961608 [Available on 08/01/17].
    38. Vardeny O, Claggett B, Packer M, Zile MR, Rouleau J, Swedberg K, Teerlink J, Desai AS, Lefkowitz M, Shi V, McMurray JJ, Solomon SD. Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM-HF trial. Eur J Heart Fail. 2016 Oct; 18(10):1228-1234. PMID: 27283779.
      View in: PubMed
    39. Collins SP, Levy PD, Martindale JL, Dunlap ME, Storrow AB, Pang PS, Albert NM, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hollander JE, Lanfear DJ, Lenihan DJ, Lindenfeld JM, Peacock WF, Sawyer DB, Teerlink J, Butler J. Clinical and Research Considerations for Patients With Hypertensive Acute Heart Failure: A Consensus Statement from the Society of Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group. J Card Fail. 2016 Aug; 22(8):618-27. PMID: 27262665.
      View in: PubMed
    40. Ter Maaten JM, Valente MA, Damman K, Cleland JG, Givertz MM, Metra M, O'Connor CM, Teerlink J, Ponikowski P, Bloomfield DM, Cotter G, Davison B, Subacius H, van Veldhuisen DJ, van der Meer P, Hillege HL, Gheorghiade M, Voors AA. Combining Diuretic Response and Hemoconcentration to Predict Rehospitalization After Admission for Acute Heart Failure. Circ Heart Fail. 2016 Jun; 9(6). PMID: 27266853.
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    41. Psotka MA, Teerlink J. Ivabradine: Role in the Chronic Heart Failure Armamentarium. Circulation. 2016 May 24; 133(21):2066-75. PMID: 27217432.
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    42. Biegus J, Hillege HL, Postmus D, Valente MA, Bloomfield DM, Cleland JG, Cotter G, Davison BA, Dittrich HC, Fiuzat M, Givertz MM, Massie BM, Metra M, Teerlink J, Voors AA, O'Connor CM, Ponikowski P. Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study. Eur J Heart Fail. 2016 Jul; 18(7):830-9. PMID: 27170455.
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    43. Davison BA, Metra M, Senger S, Edwards C, Milo O, Bloomfield DM, Cleland JG, Dittrich HC, Givertz MM, O'Connor CM, Massie BM, Ponikowski P, Teerlink J, Voors AA, Cotter G. Patient journey after admission for acute heart failure: length of stay, 30-day readmission and 90-day mortality. Eur J Heart Fail. 2016 Aug; 18(8):1041-50. PMID: 27114058.
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    44. Aras MA, Teerlink J. Lung ultrasound: a 'B-line' to the prediction of decompensated heart failure. Eur Heart J. 2016 Apr 14; 37(15):1252-4. PMID: 27080198.
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    45. Pang PS, Teerlink J, Voors AA, Ponikowski P, Greenberg BH, Filippatos G, Felker GM, Davison BA, Cotter G, Kriger J, Prescott MF, Hua TA, Severin T, Metra M. Use of High-Sensitivity Troponin T to Identify Patients With Acute Heart Failure at Lower Risk for Adverse Outcomes: An Exploratory Analysis From the RELAX-AHF Trial. JACC Heart Fail. 2016 Jul; 4(7):591-599. PMID: 27039129.
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    46. Teerlink J, Felker GM, McMurray JJ, Ponikowski P, Metra M, Filippatos GS, Ezekowitz JA, Dickstein K, Cleland JG, Kim JB, Lei L, Knusel B, Wolff AA, Malik FI, Wasserman SM. Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF Study. J Am Coll Cardiol. 2016 Mar 29; 67(12):1444-1455. PMID: 27012405.
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    47. Liu LC, Voors AA, Teerlink J, Cotter G, Davison BA, Felker GM, Filippatos G, Chen Y, Greenberg BH, Ponikowski P, Pang PS, Prescott MF, Hua TA, Severin TM, Metra M. Effects of serelaxin in acute heart failure patients with renal impairment: results from RELAX-AHF. Clin Res Cardiol. 2016 Sep; 105(9):727-37. PMID: 27017514; PMCID: PMC4988995.
    48. Metra M, Mentz RJ, Hernandez AF, Heizer GM, Armstrong PW, Clausell N, Corbalan R, Costanzo MR, Dickstein K, Dunlap ME, Ezekowitz JA, Howlett JG, Komajda M, Krum H, Lombardi C, Fonarow GC, McMurray JJ, Nieminen MS, Swedberg K, Voors AA, Starling RC, Teerlink J, O'Connor CM. Geographic Differences in Patients in a Global Acute Heart Failure Clinical Trial (from the ASCEND-HF Trial). Am J Cardiol. 2016 Jun 01; 117(11):1771-8. PMID: 27108685.
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    49. Yoon J, Fonarow GC, Groeneveld PW, Teerlink J, Whooley MA, Sahay A, Heidenreich PA. Patient and Facility Variation in Costs of VA Heart Failure Patients. JACC Heart Fail. 2016 Jul; 4(7):551-558. PMID: 26970829.
      View in: PubMed
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    180. Teerlink J, Massie BM. Nesiritide and worsening of renal function: the emperor's new clothes? Circulation. 2005 Mar 29; 111(12):1459-61. PMID: 15795361.
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    182. Sharma M, Teerlink J. A rational approach for the treatment of acute heart failure: current strategies and future options. Curr Opin Cardiol. 2004 May; 19(3):254-63. PMID: 15096959.
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    183. Hussein SJ, Teerlink J. Novel Pharmacologic Therapy of Heart Failure. Curr Treat Options Cardiovasc Med. 2003 Aug; 5(4):321-335. PMID: 12834569.
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    184. Torre-Amione G, Young JB, Colucci WS, Lewis BS, Pratt C, Cotter G, Stangl K, Elkayam U, Teerlink J, Frey A, Rainisio M, Kobrin I. Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol. 2003 Jul 02; 42(1):140-7. PMID: 12849674.
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    185. Teerlink J, Massie BM. Late breaking heart failure trials from the 2003 ACC meeting: EPHESUS and COMPANION. J Card Fail. 2003 Jun; 9(3):158-63. PMID: 12815564.
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    186. O'Connor CM, Gattis WA, Adams KF, Hasselblad V, Chandler B, Frey A, Kobrin I, Rainisio M, Shah MR, Teerlink J, Gheorghiade M. Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4). J Am Coll Cardiol. 2003 May 07; 41(9):1452-7. PMID: 12742280.
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    187. Gheorghiade M, Adams KF, Gattis WA, Teerlink J, Orlandi C, O'Connor CM. Surrogate end points in heart failure trials. Am Heart J. 2003 Feb; 145(2 Suppl):S67-70. PMID: 12594457.
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    188. Teerlink J. Dyspnea as an end point in clinical trials of therapies for acute decompensated heart failure. Am Heart J. 2003 Feb; 145(2 Suppl):S26-33. PMID: 12594449.
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    189. O'Connor CM, Gattis WA, Teerlink J, Adams KF, Gheorghiade M. Design considerations and proposed template for clinical trials in hospitalized patients with decompensated chronic heart failure. Am Heart J. 2003 Feb; 145(2 Suppl):S47-50. PMID: 12594451.
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    190. Teerlink J. Reversal of left ventricular remodeling: role of the endothelin pathway. J Card Fail. 2002 Dec; 8(6 Suppl):S494-9. PMID: 12555164.
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    191. Teerlink J. Recent heart failure trials of neurohormonal modulation (OVERTURE and ENABLE): approaching the asymptote of efficacy? J Card Fail. 2002 Jun; 8(3):124-7. PMID: 12140803.
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    192. Teerlink J. The role of endothelin in the pathogenesis of heart failure. Curr Cardiol Rep. 2002 May; 4(3):206-12. PMID: 11960589.
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    193. Teerlink J, Ratcliffe MB. Ventricular remodeling surgery for heart failure: small animals and how to measure an improvement in ventricular function. Ann Thorac Surg. 2002 May; 73(5):1368-70. PMID: 12022519.
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    194. Victal OA, Teerlink J, Gaxiola E, Wallace AW, Najar S, Camacho DH, Gutierrez A, Herrera G, Zuniga G, Mercado-Rios F, Ratcliffe MB. Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure. Circulation. 2002 Mar 19; 105(11):1317-22. PMID: 11901042.
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    195. Teerlink J. The development of new medical treatments for acute decompensated heart failure. Heart Fail Monit. 2002; 2(4):129-37. PMID: 12634887.
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    196. Massie BM, Teerlink J. Interaction between aspirin and angiotensin-converting enzyme inhibitors: real or imagined. Am J Med. 2000 Oct 01; 109(5):431-3. PMID: 11020401.
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    197. Ratcliffe MB, Wallace AW, Teerlink J, Hong J, Salahieh A, Sung SH, Keung EC, Lee RJ. Radio frequency heating of chronic ovine infarct leads to sustained infarct area and ventricular volume reduction. J Thorac Cardiovasc Surg. 2000 Jun; 119(6):1194-204. PMID: 10838539.
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    198. Teerlink J, Massie BM. The role of beta-blockers in preventing sudden death in heart failure. J Card Fail. 2000 Jun; 6(2 Suppl 1):25-33. PMID: 10908095.
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    199. Teerlink J, Jalaluddin M, Anderson S, Kukin ML, Eichhorn EJ, Francis G, Packer M, Massie BM. Ambulatory ventricular arrhythmias in patients with heart failure do not specifically predict an increased risk of sudden death. PROMISE (Prospective Randomized Milrinone Survival Evaluation) Investigators. Circulation. 2000 Jan 4-11; 101(1):40-6. PMID: 10618302.
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    200. Teerlink J, Massie BM. Beta-adrenergic blocker mortality trials in congestive heart failure. Am J Cardiol. 1999 Nov 04; 84(9A):94R-102R. PMID: 10568667.
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    201. Teerlink J, Massie BM. The interaction of ACE inhibitors and aspirin in heart failure: torn between two lovers. Am Heart J. 1999 Aug; 138(2 Pt 1):193-7. PMID: 10426826.
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    202. Teerlink J, Foster E. Valvular heart disease in pregnancy. A contemporary perspective. Cardiol Clin. 1998 Aug; 16(3):573-98, x. PMID: 9742331.
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    203. Teerlink J, Pfeffer JM, Pfeffer MA. Effect of left ventricular sphericity on the evolution of ventricular dysfunction in rats with diffuse isoproterenol-induced myocardial necrosis. J Card Fail. 1998 Mar; 4(1):45-56. PMID: 9573503.
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    204. Teerlink J. Neurohumoral mechanisms in heart failure: a central role for the renin-angiotensin system. J Cardiovasc Pharmacol. 1996; 27 Suppl 2:S1-8. PMID: 8723392.
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    205. Teerlink J, Carteaux JP, Sprecher U, Löffler BM, Clozel M, Clozel JP. Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs. Am J Physiol. 1995 Jan; 268(1 Pt 2):H432-40. PMID: 7840293.
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    206. Teerlink J, Löffler BM, Hess P, Maire JP, Clozel M, Clozel JP. Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan). Circulation. 1994 Nov; 90(5):2510-8. PMID: 7955209.
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    207. Teerlink J, Pfeffer JM, Pfeffer MA. Progressive ventricular remodeling in response to diffuse isoproterenol-induced myocardial necrosis in rats. Circ Res. 1994 Jul; 75(1):105-13. PMID: 8013068.
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    208. Teerlink J. The evolving role of angiotensin-converting enzyme inhibition in heart failure: expanding the protective envelope. J Cardiovasc Pharmacol. 1994; 24 Suppl 3:S32-7. PMID: 7700062.
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    209. Teerlink J, Gray GA, Clozel M, Clozel JP. Increased vascular responsiveness to norepinephrine in rats with heart failure is endothelium dependent. Dissociation of basal and stimulated nitric oxide release. Circulation. 1994 Jan; 89(1):393-401. PMID: 8281675.
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    210. Teerlink J, Breu V, Sprecher U, Clozel M, Clozel JP. Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries. Circ Res. 1994 Jan; 74(1):105-14. PMID: 8261583.
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    211. Teerlink J, Clozel M, Fischli W, Clozel JP. Temporal evolution of endothelial dysfunction in a rat model of chronic heart failure. J Am Coll Cardiol. 1993 Aug; 22(2):615-20. PMID: 8335837.
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    212. Teerlink J, Clozel JP. Hemodynamic variability and circadian rhythm in rats with heart failure: role of locomotor activity. Am J Physiol. 1993 Jun; 264(6 Pt 2):H2111-8. PMID: 8322940.
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    213. Teerlink J, Goldhaber SZ, Pfeffer MA. An overview of contemporary etiologies of congestive heart failure. Am Heart J. 1991 Jun; 121(6 Pt 1):1852-3. PMID: 2035416.
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