Mandar Aras, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-502-4243
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    Collapse Biography 
    Collapse Education and Training
    University of Pittsburgh, Pittsburgh, PAMD, PhD2011Medicine, Neurobiology
    Duke University Medical Center, Durham, NCResidency2014Internal Medicine
    University of California, San Francisco, CAFellowship2017Cardiovascular disease
    University of California, San Francisco, CAFellowship2018Advanced Heart Failure/Transplant
    University of California, San Francisco2020Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    UCSF2016ACC Clinical Excellence in Cardiology Fellowship Award
    Duke2014Califf Medicine Resident Research Award
    2009International Society for Zinc Biology Best Poster Award
    2008International Society for Zinc Biology Best Student Oral Presentation
    University of Pittsburgh2004Summa Cum Laude with Honors

    Collapse Overview 
    Collapse Overview
    I am an advanced heart failure and heart transplant cardiologist who has expertise in the management of patients with heart failure and pulmonary hypertension, heart transplant, and mechanical circulatory support devices. I am co-Director of the UCSF Comprehensive Amyloidosis Program, and the clinical cardiology lead for the UCSF HHT Center of Excellence. In addition to my expertise in heart failure and cardiomyopathies, I developed a specific focus in cardio-oncology (management of cardiovascular issues in cancer patients).

    My research interests focus on cardiac amyloidosis and in understanding risk predictors and outcomes of cancer patients with heart disease.

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    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Long-term Safety And Tolerability Of Acoramidis (AG10) In Symptomatic Transthyretin Amyloid Cardiomyopathy: 4-year Update From An Ongoing, Phase 2, Open-label Extension Study. Journal of Cardiac Failure. 2024 Jan 1; 30(1):221. Masri MA, Aras AM, Falk FR, Grogan GM, Jacoby JD, Maurer MM, Shah SS, Witteles WR, Wong WP, Ji JA, Du DJ, Siddhanti SS, Sinha SU, Fox FJ, Judge JD. .
      View in: Publisher Site   Mentions:
    2. Left atrial strain is reduced following trastuzumab in breast cancer patients. Echocardiography. 2024 Jan; 41(1):e15751. Lassen MCH, Arya F, Biering-Sørensen T, Reeh JLT, Melisko ME, Sarwary S, Baik AH, Aras MA, Qasim A. PMID: 38284677.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. The Cardiac Amyloidosis Registry Study (CARS): Rationale, Design and Methodology. J Card Fail. 2023 Oct 30. Stern LK, Grodin JL, Maurer MS, Ruberg FL, Patel AR, Khouri MG, Roth LR, Aras MA, Bhardwaj A, Bhattacharya P, Brailovsky Y, Drachman BM, Ebong IA, Fine NM, Gaggin H, Gopal D, Griffin J, Judge D, Kim P, Mitchell J, Mitter SS, Mohan RC, Ramos H, Reyentovich A, Sheikh FH, Sperry B, Carter S, Urey M, Vaishnav J, Vest AR, Kittleson MM, Patel JK. PMID: 37907148.
      View in: PubMed   Mentions:    Fields:    
    4. Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV. J Am Heart Assoc. 2023 10 17; 12(20):e030896. Durstenfeld MS, Peluso MJ, Spinelli MA, Li D, Hoh R, Chenna A, Yee B, Winslow J, Petropoulos C, Gandhi M, Henrich TJ, Aras MA, Long CS, Deeks SG, Hsue PY. PMID: 37830367; PMCID: PMC10757521.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Reduced Exercise Capacity, Chronotropic Incompetence, and Early Systemic Inflammation in Cardiopulmonary Phenotype Long Coronavirus Disease 2019. J Infect Dis. 2023 08 31; 228(5):542-554. Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Kelly JD, Glidden DV, Henrich TJ, Martin JN, Lee YJ, Aras MA, Long CS, Grandis DJ, Deeks SG, Hsue PY. PMID: 37166076; PMCID: PMC10686699.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Daratumumab Plus Bortezomib and Dexamethasone in Newly Diagnosed Systemic Light Chain Amyloidosis. Curr Probl Cancer. 2023 06; 47(3):100953. Kennedy VE, Natsuhara K, Maringanti SA, Shah ND, Arora S, Wolf J, Martin TG, Aras MA, Chung A, Wong SW. PMID: 36807996.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning. J Card Fail. 2023 07; 29(7):1017-1028. Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH. PMID: 36706977; PMCID: PMC10363571.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Post-transplant ejection fraction and renal failure in cardiac transplant recipients: An analysis of the OPTN database. Clin Transplant. 2023 02; 37(2):e14881. Lai M, Aras MA, Park M. PMID: 36504467.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design. Respir Res. 2022 Dec 17; 23(1):355. Benza RL, Franco V, Aras MA, Spikes L, Grinnan D, Satler C. PMID: 36527025.
      View in: PubMed   Mentions: 1     Fields:    
    10. Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022 10 03; 5(10):e2236057. Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY. PMID: 36223120; PMCID: PMC9557896.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    11. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. Eur J Cancer. 2022 12; 177:197-205. Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Itzhaki Ben Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, International ICI-myocarditis registry contributors. PMID: 36030143; PMCID: PMC10165738.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report. J Oncol Pharm Pract. 2022 Apr; 28(3):729-732. Banerjee R, Lo M, Klein L, Aras M, Logan AC. PMID: 34846217.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis. Circulation. 2021 11 02; 144(18):1521-1523. Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek S, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehman L, Ederhy S, Moslehi J, Salem JE, International ICI-Myocarditis Registry†. PMID: 34723640; PMCID: PMC8567307.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    14. Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review. JAMA Cardiol. 2021 11 01; 6(11):1329-1337. Lehmann LH, Cautela J, Palaskas N, Baik AH, Meijers WC, Allenbach Y, Alexandre J, Rassaf T, Müller OJ, Aras M, Asnani AH, Deswal A, Laufer-Perl M, Thuny F, Kerneis M, Hayek SS, Ederhy S, Salem JE, Moslehi JJ. PMID: 34232253.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    15. Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis. Current Cardiovascular Risk Reports. 2021 Apr 4; 15(6):8. Spencer-Bonilla SG, Njoroge NJ, Pearson PK, Witteles WR, Aras AM, Alexander AK. .
      View in: Publisher Site   Mentions:
    16. Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors. Clin Sci (Lond). 2021 03 12; 135(5):703-724. Baik AH, Tsai KK, Oh DY, Aras MA. PMID: 33686402; PMCID: PMC8647663.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Predictors of steroid-refractory immune checkpoint inhibitor associated myocarditis. European Heart Journal. 2020 Nov 1; 41(Supplement_2). Power PJ, Meijers MW, Fenioux FC, Tamura TY, Asnani AA, Alexandre AJ, Cautela CJ, Aras AM, Lehmann LL, Perl PM, Narezkina NA, Gilstrap GL, Ederhy ES, Moslehi MJ, Salem SJ. .
      View in: Publisher Site   Mentions:
    18. Inflammatory Biomarkers to Detect Immune Checkpoint Inhibitor-Associated Cardiotoxicity in Lung Cancer Patients: Ready for Prime Time? JACC CardioOncol. 2020 Sep; 2(3):503-505. Aras MA, Power JR, Moslehi JJ. PMID: 34396257; PMCID: PMC8352214.
      View in: PubMed   Mentions: 1  
    19. Echo-Strain to Check Up on Checkpoint Inhibitors. J Am Coll Cardiol. 2020 02 11; 75(5):479-481. Abraham TP, Aras MA. PMID: 32029129.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Heart-lung transplantation: A viable option for connective tissue diseases. Clin Transplant. 2020 02; 34(2):e13776. Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T. PMID: 31867763.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Noninvasive estimation of pulmonary vascular resistance improves portopulmonary hypertension screening in liver transplant candidates. Clin Transplant. 2019 07; 33(7):e13585. DesJardin JT, Manicardi M, Svetlichnaya Y, Kolaitis NA, Papolos AI, Selby VN, Zier LS, Klein L, Aras MA, Yao FY, Roberts JP, De Marco T. PMID: 31074522.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Pulmonary Hypertension Due to Left Heart Disease: an Update. Curr Cardiol Rep. 2019 05 27; 21(7):62. Aras MA, Psotka MA, De Marco T. PMID: 31134443.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    23. Fully Automated Echocardiogram Interpretation in Clinical Practice. Circulation. 2018 10 16; 138(16):1623-1635. Zhang J, Gajjala S, Agrawal P, Tison GH, Hallock LA, Beussink-Nelson L, Lassen MH, Fan E, Aras MA, Jordan C, Fleischmann KE, Melisko M, Qasim A, Shah SJ, Bajcsy R, Deo RC. PMID: 30354459; PMCID: PMC6200386.
      View in: PubMed   Mentions: 215     Fields:    Translation:Humans
    24. Lung ultrasound: a 'B-line' to the prediction of decompensated heart failure. Eur Heart J. 2016 Apr 14; 37(15):1252-4. Aras MA, Teerlink JR. PMID: 27080198.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons. Antioxid Redox Signal. 2011 Oct 15; 15(8):2249-63. Aras MA, Aizenman E. PMID: 20849376; PMCID: PMC3166180.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    26. Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia. Eur J Neurosci. 2009 Dec; 30(12):2250-7. Aras MA, Saadi RA, Aizenman E. PMID: 20092568; PMCID: PMC2811322.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    27. Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling. J Physiol. 2009 Sep 15; 587(Pt 18):4393-404. Redman PT, Hartnett KA, Aras MA, Levitan ES, Aizenman E. PMID: 19622611; PMCID: PMC2766646.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    28. Intracellular zinc inhibits KCC2 transporter activity. Nat Neurosci. 2009 Jun; 12(6):725-7. Hershfinkel M, Kandler K, Knoch ME, Dagan-Rabin M, Aras MA, Abramovitch-Dahan C, Sekler I, Aizenman E. PMID: 19430470; PMCID: PMC2737597.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    29. Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning. J Neurochem. 2009 Jul; 110(1):106-17. Aras MA, Hara H, Hartnett KA, Kandler K, Aizenman E. PMID: 19453299; PMCID: PMC2719843.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    30. Assessment of cell viability in primary neuronal cultures. Curr Protoc Neurosci. 2008 Jul; Chapter 7:Unit 7.18. Aras MA, Hartnett KA, Aizenman E. PMID: 18633999.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    31. Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis. Neuropathology. 2005 Dec; 25(4):315-25. Chalovich EM, Koike MA, Aras MA, Murphey-Corb M, Wiley CA, Jordan-Sciutto KL. PMID: 16382780.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. Obligatory role of ASK1 in the apoptotic surge of K+ currents. Neurosci Lett. 2005 Oct 28; 387(3):136-40. Aras MA, Aizenman E. PMID: 16006035; PMCID: PMC2947746.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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