Arthur Wallace, MD, PhD

Title(s)Professor Emeritus, Anesthesia
SchoolSchool of Medicine
Address4150 Clement Street, #201B
San Francisco CA 94121
Phone415-221-4810 ext. 23732
ORCID ORCID Icon0000-0003-2809-5104 Additional info
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    University of California, San FranciscoResidency School of Medicine
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

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    Art Wallace, M.D., Ph.D. is a professor and vice-chair of anesthesiology and perioperative care at the University of California, San Francisco and Chief of the Anesthesia Service at the Veterans Affairs Medical Center in San Francisco. His clinical practice includes cardiac and non-cardiac anesthesiology as well as ICU and preoperative clinical care. He completed a B.S. in engineering and applied science with a specialty in electrical engineering at Yale. He then completed an M.D. and Ph.D. at Johns Hopkins Medical School with his Ph.D. in biomedical engineering with research in systems physiology and autonomic control of the vasculature. He then moved to the University of California, San Francisco where he completed an internship in internal medicine, a residency in anesthesiology, and a cardiac anesthesiology fellowship. His research at UCSF has included numerous projects in animals and patients including device development for monitoring, surgical therapy of heart failure, and the off pump CABG, as well as drug development and testing. He is best known for his work developing medications for the prevention of perioperative cardiac morbidity and mortality. He was one of the developers of perioperative beta blockade and has assisted more than 200 hospitals set up perioperative beta blocker programs. His present work includes development medications to reduce perioperative cardiac risk, development of the ECOM cardiac output monitor, developing a non-invasive respiratory monitor, a device to provide electronic sedation, testing and development of surgical therapies for heart failure, implementation of perioperative beta blockade, developing therapies to prevent perioperative and ICU related PTSD, and developing computer systems to improve systems based medicine. He lectures extensively on cardiac risk reduction and has produced an on-line course on cardiac risk reduction. intelligence.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study. BMJ Open. 2021 12 31; 11(12):e050051. Wallace AW, Cirillo PM, Ryan JC, Krigbaum NY, Badathala A, Cohn BA. PMID: 34972763; PMCID: PMC8720638.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. SARS-CoV-2 vaccine protection and deaths among US veterans during 2021. Science. 2022 01 21; 375(6578):331-336. Cohn BA, Cirillo PM, Murphy CC, Krigbaum NY, Wallace AW. PMID: 34735261.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCellsPHPublic Health
    3. A finite element model of the cardiac ventricles with coupled circulation: Biventricular mesh generation with hexahedral elements, airbags and a functional mockup interface to the circulation. Comput Biol Med. 2021 10; 137:104840. Zhang Y, Adams J, Wang VY, Horwitz L, Tartibi M, Morgan AE, Kim J, Wallace AW, Weinsaft JW, Ge L, Ratcliffe MB. PMID: 34508972.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Age affects temporal response, but not durability, to serial ketamine infusions for treatment refractory depression. Psychopharmacology (Berl). 2021 Nov; 238(11):3229-3237. Pennybaker S, Roach BJ, Fryer SL, Badathala A, Wallace AW, Mathalon DH, Marton TF. PMID: 34363507.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    5. A kinematic model-based analysis framework for 3D Cine-DENSE-validation with an axially compressed gel phantom and application in sheep before and after antero-apical myocardial infarction. Magn Reson Med. 2021 10; 86(4):2105-2121. Wang VY, Tartibi M, Zhang Y, Selvaganesan K, Haraldsson H, Auger DA, Faraji F, Spaulding K, Takaba K, Collins A, Aguayo E, Saloner D, Wallace AW, Weinsaft JW, Epstein FH, Guccione J, Ge L, Ratcliffe MB. PMID: 34096083.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Sharing Lessons Learned to Prevent Adverse Events in Anesthesiology Nationwide. J Patient Saf. 2021 06 01; 17(4):e343-e349. Soncrant C, Neily J, Sum-Ping SJT, Wallace AW, Mariano ER, Leissner KB, Mills PD, Mazzia L, Paull DE. PMID: 31135598.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain. J Mech Behav Biomed Mater. 2021 07; 119:104431. Zhang Y, Wang VY, Morgan AE, Kim J, Tafreshi R, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB. PMID: 33930653.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    8. Combined Intravenous Sildenafil and L-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow. Drugs R D. 2020 Sep; 20(3):279-290. Brzezinski M, Dincheva GR, Alloo K, Wong C, Feng CM, Tom WL, Salahieh A, Wallace AW. PMID: 32720006; PMCID: PMC7419398.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep. PLoS One. 2020; 15(6):e0234896. Giao DM, Wang Y, Rojas R, Takaba K, Badathala A, Spaulding KA, Soon G, Zhang Y, Wang VY, Haraldsson H, Liu J, Saloner D, Guccione JM, Ge L, Wallace AW, Ratcliffe MB. PMID: 32569290; PMCID: PMC7307770.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. J Biomed Mater Res A. 2020 08 01; 108(8):1736-1746. Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB. PMID: 32270584; PMCID: PMC8174154.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    11. Freedom From Opioids After Total Knee Arthroplasty. J Arthroplasty. 2019 05; 34(5):893-897. Kuo AC, Raghunathan K, Lartigue AM, Bryan WE, Pepin MJ, Takemoto S, Wallace AW. PMID: 30777627.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Investigation of possible aqueous phase formation during vaporization of sevoflurane. J Anaesthesiol Clin Pharmacol. 2019 Jan-Mar; 35(1):76-80. Varughese S, Kalthod VG, Petzel JP, Bacher HP, Wallace AW. PMID: 31057245; PMCID: PMC6495606.
      View in: PubMed   Mentions:
    13. E-cigarettes versus nicotine patches for perioperative smoking cessation: a pilot randomized trial. PeerJ. 2018; 6:e5609. Lee SM, Tenney R, Wallace AW, Arjomandi M. PMID: 30280019; PMCID: PMC6166615.
      View in: PubMed   Mentions: 19     Fields:    
    14. Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. PLoS One. 2018; 13(2):e0192720. Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB. PMID: 29432443; PMCID: PMC5809072.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    15. Sevoflurane Contamination: Water Accumulation in Sevoflurane Vaporizers Can Allow Bacterial Growth in the Vaporizer. A A Case Rep. 2016 Jun 15; 6(12):399-401. Wallace AW. PMID: 27301057.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    16. Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone. Ann Thorac Surg. 2016 May; 101(5):1691-9. Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB. PMID: 26857634; PMCID: PMC4842099.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    17. In Reply. Anesthesiology. 2016 Feb; 124(2):513-4. Lee SM, Takemoto S, Wallace AW. PMID: 26785436.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Association between Withholding Angiotensin Receptor Blockers in the Early Postoperative Period and 30-day Mortality: A Cohort Study of the Veterans Affairs Healthcare System. Anesthesiology. 2015 Aug; 123(2):288-306. Lee SM, Takemoto S, Wallace AW. PMID: 26200181.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    19. Effectiveness of preoperative beta-blockade on intra-operative heart rate in vascular surgery cases conducted under regional or local anesthesia. Springerplus. 2014; 3:227. Mudumbai SC, Wagner T, Mahajan S, King R, Heidenreich PA, Hlatky M, Wallace AW, Mariano ER. PMID: 24855591; PMCID: PMC4024108.
      View in: PubMed   Mentions: 1  
    20. Thirty-day mortality risk associated with the postoperative nonresumption of angiotensin-converting enzyme inhibitors: a retrospective study of the Veterans Affairs Healthcare System. J Hosp Med. 2014 May; 9(5):289-96. Mudumbai SC, Takemoto S, Cason BA, Au S, Upadhyay A, Wallace AW. PMID: 24799360.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    21. Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction. Ann Thorac Surg. 2013 May; 95(5):1619-25. Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. PMID: 23523189; PMCID: PMC3640420.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    22. Left ventricular pressure gating in ovine cardiac studies: a software-based method. J Biomech Eng. 2013 Mar 01; 135(3):34502. Acevedo-Bolton G, Suzuki T, Malhotra D, Zhang Z, Wallace AW, Guccione JM, Saloner DA, Ratcliffe MB. PMID: 24231818; PMCID: PMC3705966.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    23. Risk of acute myocardial infarction in patients with total hip or knee replacement: comment on "Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study". Arch Intern Med. 2012 Sep 10; 172(16):1235-6. Wallace AW. PMID: 22825029.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. The benefit of enhanced contractility in the infarct borderzone: a virtual experiment. Front Physiol. 2012; 3:86. Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. PMID: 22509168; PMCID: PMC3321638.
      View in: PubMed   Mentions: 7  
    25. A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure. Comput Methods Biomech Biomed Engin. 2013; 16(8):807-18. Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM. PMID: 22248290; PMCID: PMC3367128.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    26. The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation. Ann Thorac Surg. 2012 Mar; 93(3):776-82. Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L. PMID: 22245588; PMCID: PMC3432639.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    27. Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction. Ann Thorac Surg. 2011 Nov; 92(5):1614-20. Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB. PMID: 21945222; PMCID: PMC3253877.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    28. A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction. J Biomech Eng. 2011 Sep; 133(9):094506. Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM. PMID: 22010752; PMCID: PMC3207355.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    29. Perioperative β-blockade: atenolol is associated with reduced mortality when compared to metoprolol. Anesthesiology. 2011 Apr; 114(4):824-36. Wallace AW, Au S, Cason BA. PMID: 21372680.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    30. Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction. J Biomech Eng. 2011 Apr; 133(4):044501. Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM. PMID: 21428685; PMCID: PMC3097530.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    31. Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling. Ann Thorac Surg. 2011 Jan; 91(1):150-6. Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB. PMID: 21172505; PMCID: PMC3058250.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    32. Association of the pattern of use of perioperative β-blockade and postoperative mortality. Anesthesiology. 2010 Oct; 113(4):794-805. Wallace AW, Au S, Cason BA. PMID: 20864832.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    33. First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation. Ann Thorac Surg. 2010 May; 89(5):1546-53. Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. PMID: 20417775; PMCID: PMC2887313.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    34. Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone. J Thorac Cardiovasc Surg. 2010 Jul; 140(1):233-9, 239.e1-4. Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. PMID: 20299030; PMCID: PMC2907919.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    35. A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. J Biomech Eng. 2009 Nov; 131(11):111001. Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM. PMID: 20016753; PMCID: PMC2793686.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    36. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2008 May; 135(5):1094-102, 1102.e1-2. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM. PMID: 18455590; PMCID: PMC3773224.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    37. Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):1017-24. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB. PMID: 17903523; PMCID: PMC2615826.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    38. Clonidine and modification of perioperative outcome. Curr Opin Anaesthesiol. 2006 Aug; 19(4):411-7. Wallace AW. PMID: 16829723.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    39. The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):579-586.e3. Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB. PMID: 16515908; PMCID: PMC1482534.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    40. Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep. J Thorac Cardiovasc Surg. 2005 Oct; 130(4):1032-8. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB. PMID: 16214516; PMCID: PMC1475735.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    41. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H692-700. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. PMID: 15778283.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    42. Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. J Thorac Cardiovasc Surg. 2005 Feb; 129(2):382-90. Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB. PMID: 15678050.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    43. Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. Ann Thorac Surg. 2005 Jan; 79(1):185-93. Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. PMID: 15620941.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    44. Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1844-50. Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. PMID: 15604126.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    45. Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery. Anesthesiology. 2004 Aug; 101(2):284-93. Wallace AW, Galindez D, Salahieh A, Layug EL, Lazo EA, Haratonik KA, Boisvert DM, Kardatzke D. PMID: 15277909.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCTClinical Trials
    46. Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study. Ann Thorac Surg. 2003 Oct; 76(4):1171-80; discussion 1180. Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB. PMID: 14530007.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    47. Is it time to get on the fast track or stay on the slow track? Anesthesiology. 2003 Oct; 99(4):774. Wallace AW. PMID: 14508304.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy. ASAIO J. 2002 Sep-Oct; 48(5):508-13. Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB. PMID: 12296571.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    49. Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure. Circulation. 2002 Mar 19; 105(11):1317-22. Victal OA, Teerlink JR, Gaxiola E, Wallace AW, Najar S, Camacho DH, Gutierrez A, Herrera G, Zuniga G, Mercado-Rios F, Ratcliffe MB. PMID: 11901042.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
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