David Lovett, MD

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
AddressLocation Required, #Suite 40
Phone415-750-2032
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    Collapse Biography 
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    American Society of Clinical Investigation

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    Education:
    A.B. Indiana University, Zoology and Chemistry, Highest Distinction
    M.D. Indiana University, Highest Distinction
    Resident in Internal Medicine, Yale University
    Chief Resident in Internal Medicine, Yale University
    Fellow in Nephrology, Yale University
    Fellow, Alexander von Humboldt Stiftung, Medizinische Hochschule Hannover Germany

    Clinical and Academic Activities:
    Professor of Medicine in Residence, Step 9, emeritus 2020
    Chief, Nephrology Section SFVAMC, 1995-2019

    University/Public Service:
    Principal Investigator UCSF T32 Academic Training Program in Nephrology 2006-2016
    Member, UCSF Committee on Academic Personnel 2016-2017
    Vice Chair, UCSF Committee on Academic Personnel 2017-2018
    Chair, UCSF Committee on Academic Personnel 2018-2019

    Scholarly Activity: Our laboratory has primarily focused in recent years on an examination of the role of matrix metalloproteinase 2 in progressive cardiac and renal failure. These studies have included determinations of transcriptional regulatory networks, impact of promoter haplotypes on gene expression and generation of a series of transgenic mice to directly test the significance of MMP-2 expression on renal and cardiac disease. We have demonstrated that MMP-2 alone is sufficient to trigger the entire process of progressive renal disease seen in humans, including glomerulosclerosis, tubular atrophy and interstitial fibrosis without the requirement for superimposed injury. In the heart we have published a series of studies demonstrating that MMP-2 directly mediates cardiomyocyte apoptosis and contractile failure. More recently we have characterized (Lovett, et al., PLoS One 2012) a novel intracelllular isoform of MMP-2 that activates innate immunity. The isoform is generated by oxidative stress mediated activation of an alternative promoter in the first intron of the MMP-2 gene, thereby generating an intracellular, active N-terminal truncated enzyme. Transgenic mice expressing this isoform in the heart develop severe cardiomyocyte hypertrophy, inflammation and sytolic failure. Transgenic mice expressing this isoform in the kidney develop progressive tubular atrophy due mitochondrial damage mediated regulated necrosis. We are currently determining the extent of expression of this MMP-2 isoform in clinical specimens of cardiac and renal tissue using a combination of histochemical and epigenetic approaches. In addition, we are studying the epigenetic regulation of the MMP-2 intronic promoter using a novel series of transgenic reporter mice and epigenetic techniques. We believe that both isoforms of MMP-2 represent appealing therapeutic targets and we are currently developing antibody and siRNA-based strategies to selectively inhibit the MMP-2 isoforms in models of cardiac and renal disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Mitochondrial Matrix Metalloproteinase-2 and Cardiac Injury
    NIH I01BX000593Oct 1, 2009 - Sep 30, 2014
    Role: Principal Investigator
    Pathobiology of Renal Matrix Metabolism
    NIH R56DK039776May 15, 2005 - Feb 28, 2006
    Role: Principal Investigator
    Mechanisms of Cardioprotection in Ischemia and Failure
    NIH P01HL068738Aug 1, 2002 - Jul 31, 2008
    Role: Co-Investigator
    Pathology of Renal Matrix Metabolism
    NIH R01DK039776Sep 30, 1987 - Dec 31, 2011
    Role: Principal Investigator
    AXIAL HETEROGENEITY OF PROXIMAL TUBULE ANION TRANSPORT
    NIH R01DK037423Jul 1, 1986 - Jun 30, 1996
    Role: Principal Investigator
    Academic Training Program in Nephrology
    NIH T32DK007219Jul 1, 1976 - Jun 30, 2023
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. J Biomed Mater Res A. 2020 08 01; 108(8):1736-1746. Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB. PMID: 32270584; PMCID: PMC8174154.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    2. Nonsurgical Periodontal Therapy in CKD: Findings of the Kidney and Periodontal Disease (KAPD) Pilot Randomized Controlled Trial. Kidney Med. 2020 Jan-Feb; 2(1):49-58. Grubbs V, Garcia F, Vittinghoff E, Jue BL, Ryder M, Lovett DH, Offenbacher S, Taylor G, Ganz P, Bibbins-Domingo K, Powe NR. PMID: 32734226; PMCID: PMC7380373.
      View in: PubMed   Mentions: 4  
    3. Enhanced cardiac expression of two isoforms of matrix metalloproteinase-2 in experimental diabetes mellitus. PLoS One. 2019; 14(8):e0221798. Lee HW, Lee SJ, Lee MY, Park MW, Kim SS, Shin N, Lovett DH, Bae SS, Ahn J, Park JS, Oh JH, Choi JH, Lee HC, Cha KS, Hong TJ, Song SH. PMID: 31461499; PMCID: PMC6713391.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    4. Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse. Muscles Ligaments and Tendons Journal. 2019 Jan 1; 03(01):35. Zhang ZQ, Joshi JS, Lovett LD, Manzano MG, Kim KH, Liu LX. .
      View in: Publisher Site   Mentions:
    5. Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy. Am J Physiol Heart Circ Physiol. 2019 01 01; 316(1):H224-H232. Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy N, Dulam P, Lovett DH, Simpson PC, Baker AJ. PMID: 30412439; PMCID: PMC6859419.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease. Kidney Res Clin Pract. 2018 Sep; 37(3):222-229. Rhee H, Han M, Kim SS, Kim IY, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH. PMID: 30254846; PMCID: PMC6147188.
      View in: PubMed   Mentions: 5  
    7. The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus. BMC Nephrol. 2018 09 25; 19(1):248. Kim IY, Kim SS, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Han M, Rhee H, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH. PMID: 30253743; PMCID: PMC6156952.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. PLoS One. 2018; 13(2):e0192720. Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB. PMID: 29432443; PMCID: PMC5809072.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    9. α1A-Subtype adrenergic agonist therapy for the failing right ventricle. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1109-H1118. Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ. PMID: 28822963; PMCID: PMC5814653.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    10. Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR Biomed. 2017 Oct; 30(10). Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. PMID: 28708304; PMCID: PMC5618802.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    11. Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis. Physiol Rep. 2017 Jun; 5(11). Landolt L, Eikrem Ø, Strauss P, Scherer A, Lovett DH, Beisland C, Finne K, Osman T, Ibrahim MM, Gausdal G, Ahmed L, Lorens JB, Thiery JP, Tan TZ, Sekulic M, Marti HP. PMID: 28596300; PMCID: PMC5471444.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    12. MP501A SPATIAL DISTRIBUTION OF TWO ISOFORMS OF MATRIX METALLOPROTEINASE-2 IN DIABETIC KIDNEY ACCORDING TO THE TIME OF DIABETIC MILIEU. Nephrology,Dialysis and Transplantation. 2017 May 1; 32(suppl_3):iii612-iii613. Song SS, Rhee RH, Kim KI, Seong SE, Lee LD, Lee LS, Kwak KI, Lee LM, Bang BS, Lovett LD. .
      View in: Publisher Site   Mentions:
    13. a1A-Subtype Adrenergic Agonist Therapy for Failing Right Ventricle. The FASEB Journal. 2017 Apr 1; 31(S1). Cowley CP, Wang WG, Swigart SP, Lovett LD, Simpson SP, Baker BA. .
      View in: Publisher Site   Mentions:
    14. An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury. Am J Physiol Renal Physiol. 2017 06 01; 312(6):F1166-F1183. Ceron CS, Baligand C, Joshi S, Wanga S, Cowley PM, Walker JP, Song SH, Mahimkar R, Baker AJ, Raffai RL, Wang ZJ, Lovett DH. PMID: 28331061; PMCID: PMC5495883.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy. PLoS One. 2017; 12(2):e0171625. Kim SS, Shin N, Bae SS, Lee MY, Rhee H, Kim IY, Seong EY, Lee DW, Lee SB, Kwak IS, Lovett DH, Song SH. PMID: 28178341; PMCID: PMC5298282.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease. Contemp Clin Trials. 2017 02; 53:143-150. Grubbs V, Garcia F, Jue BL, Vittinghoff E, Ryder M, Lovett D, Carrillo J, Offenbacher S, Ganz P, Bibbins-Domingo K, Powe NR. PMID: 28011387; PMCID: PMC6237429.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    17. a1A-Subtype Adrenergic Therapy is Beneficial for Failing Right Ventricle (RV). The FASEB Journal. 2016 Apr 1; 30(S1). Cowley CP, Wang WG, Joshi JS, Lovett LD, Simpson SP, Baker BA. .
      View in: Publisher Site   Mentions:
    18. Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis. J Cardiovasc Pharmacol. 2016 Jan; 67(1):47-56. Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL. PMID: 26322923; PMCID: PMC4703534.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    19. Abstract 17311: Molecular Memory and the Epigenetic Regulation of Cardiac Intracellular Matrix Metalloproteinase-2. Circulation. 2015 Nov 10; 132(suppl_3). Lovett LD, Luk LS, Uttarwar UL, Joshi JS, RAffai RR. .
      View in: Publisher Site   Mentions:
    20. Two Distinct Isoforms of Matrix Metalloproteinase-2 Are Associated with Human Delayed Kidney Graft Function. PLoS One. 2015; 10(9):e0136276. Wanga S, Ceron CS, Delgado C, Joshi SK, Spaulding K, Walker JP, Song S, Olson JL, Lovett DH. PMID: 26379248; PMCID: PMC4574928.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    21. Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury. J Orthop Res. 2016 Mar; 34(3):502-9. Joshi SK, Lee L, Lovett DH, Kang H, Kim HT, Delgado C, Liu X. PMID: 26213293.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2015 Sep; 309(5):H888-96. Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. PMID: 26116709; PMCID: PMC4591405.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    23. RR15. Renal Progression in the Advanced Chronic Kidney Disease Populations: Creation of the ESRD Prediction Scorecard. Journal of Vascular Surgery. 2015 Jun 1; 61(6):195s. Lau LM, Meier MJ, Gasper GW, Lovett LD, Velez VP, Owens OC. .
      View in: Publisher Site   Mentions:
    24. FP458THE EXPRESSION OF FULL LENGTH MMP-2 AND INTRACELLULAR N-TERMINAL TRUNCATED MMP-2 ISOFORM IN DIABETIC KIDNEY DISEASE. Nephrology,Dialysis and Transplantation. 2015 May 1; 30(suppl_3):iii224-iii224. Song SS, Kwak KI, Lee LM, Seong SE, Rhee RH, Kim KI, Lee LD, Lee LS, Lovett LD. .
      View in: Publisher Site   Mentions:
    25. Abstract 23: Immunosuppression with FTY720 Reverses Cardiac Dysfunction to Prevent Chronic Heart Failure in Mice that Survive Diet-induced Myocardial Infarction. Arteriosclerosis Thrombosis and Vascular Biology. 2015 May 1; 35(suppl_1). Luk LF, Kim KR, Li LK, Ching CD, Joshi JS, Honbo HN, Imhof II, Zhu ZB, Lovett LD, Karliner KJ, Raffai RR. .
      View in: Publisher Site   Mentions:
    26. The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts. J Cell Sci. 2015 May 15; 128(10):1901-11. Alam SG, Lovett D, Kim DI, Roux KJ, Dickinson RB, Lele TP. PMID: 25908852; PMCID: PMC4457156.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    27. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles Ligaments Tendons J. 2014 Oct-Dec; 4(4):446-54. Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim HT, Liu X. PMID: 25767782; PMCID: PMC4327354.
      View in: PubMed   Mentions: 13  
    28. Upregulation of a1A-Subtype Adrenergic Signaling is Beneficial in Failing Right Ventricle (RV). Biophysical Journal. 2015 Jan 1; 108(2):293a-294a. Cowley CP, Wang WG, Chang CA, Lovett LD, Stull SJ, Simpson SP, Baker BA. .
      View in: Publisher Site   Mentions:
    29. Navigating toward research success in times of uncertainty: funding opportunities for early career investigators in nephrology. Am J Kidney Dis. 2015 Mar; 65(3):381-3. Ikizler TA, Lovett DH, Chertow GM, Mitch WE, Schiller B. PMID: 25542413.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles Ligaments Tendons J. 2014 Jul; 4(3):362-70. Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim H, Liu X. PMID: 25489556; PMCID: PMC4241429.
      View in: PubMed   Mentions: 4  
    31. A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium. Front Physiol. 2014; 5:363. Lovett DH, Chu C, Wang G, Ratcliffe MB, Baker AJ. PMID: 25309453; PMCID: PMC4174733.
      View in: PubMed   Mentions: 11  
    32. Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Am J Physiol Heart Circ Physiol. 2014 Oct 15; 307(8):H1150-8. Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ. PMID: 25128171; PMCID: PMC4200338.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Abstract 363: Prolonged Upregulation of Proinflammatory and Profibrotic Genes is Characteristic of Successful Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis and Vascular Biology. 2014 May 1; 34(suppl_1). Walker WJ, Toy TR, Thomas TS, Conte CM, Eichler EC, Lovett LD, Gasper GW, Owens OC. .
      View in: Publisher Site   Mentions:
    34. Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with end-stage renal disease. J Vasc Surg. 2014 Jul; 60(1):176-83. Walker JP, Hiramoto JS, Gasper WJ, Auyang P, Conte MS, Rapp JH, Lovett DH, Owens CD. PMID: 24582700; PMCID: PMC4074433.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. PLoS One. 2013; 8(7):e68154. Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. PMID: 23874529; PMCID: PMC3712965.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    36. Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse. Muscles Ligaments Tendons J. 2013 Jan; 3(1):35-41. Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X. PMID: 23885343; PMCID: PMC3676162.
      View in: PubMed   Mentions: 9  
    37. Vitamin D Deficiency Is Associated With Mortality and Adverse Vascular Access Outcomes in the ESRD Population. Journal of Vascular Surgery. 2013 May 1; 57(5):101s. Walker WJ, Hiramoto HJ, Auyang AP, Alley AH, Conte CM, Lovett LD, Rapp RJ, Owens OC. .
      View in: Publisher Site   Mentions:
    38. Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H946-53. Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ. PMID: 23355341; PMCID: PMC3625891.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    39. mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats. J Orthop Res. 2013 May; 31(5):724-30. Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT. PMID: 23239524; PMCID: PMC4393845.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    40. Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene. J Biol Chem. 2012 Nov 23; 287(48):40570-85. Chintala H, Liu H, Parmar R, Kamalska M, Kim YJ, Lovett D, Grant MB, Chaqour B. PMID: 23048035; PMCID: PMC3504771.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    41. A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. PLoS One. 2012; 7(4):e34177. Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS. PMID: 22509276; PMCID: PMC3317925.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    42. The safety of an adenosine A(1)-receptor antagonist, rolofylline, in patients with acute heart failure and renal impairment: findings from PROTECT. Drug Saf. 2012 Mar 01; 35(3):233-44. Teerlink JR, Iragui VJ, Mohr JP, Carson PE, Hauptman PJ, Lovett DH, Miller AB, Piña IL, Thomson S, Varosy PD, Zile MR, Cleland JG, Givertz MM, Metra M, Ponikowski P, Voors AA, Davison BA, Cotter G, Wolko D, Delucca P, Salerno CM, Mansoor GA, Dittrich H, O'Connor CM, Massie BM. PMID: 22339573.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    43. Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model. J Orthop Res. 2012 Sep; 30(9):1440-6. Liu X, Joshi SK, Samagh SP, Dang YX, Laron D, Lovett DH, Bodine SC, Kim HT, Feeley BT. PMID: 22378614.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    44. Abstract 18433: A Novel Intracellular Isoform of Matrix Metalloproteinase-2 Activates Innate Immunity and Leads to Cardiac Failure. Circulation. 2011 Nov 22; 124(suppl_21). Lovett LD, Mahimkar MR, Maklashina ME, Cecchini CG, Karliner KJ. .
      View in: Publisher Site   Mentions:
    45. Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype. Carcinogenesis. 2011 Dec; 32(12):1806-14. Mahimkar R, Alfonso-Jaume MA, Cape LM, Dahiya R, Lovett DH. PMID: 21965271; PMCID: PMC3220610.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    46. Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):253-60. Findeisen HM, Gizard F, Zhao Y, Cohn D, Heywood EB, Jones KL, Lovett DH, Howatt DA, Daugherty A, Bruemmer D. PMID: 21088250; PMCID: PMC3025410.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    47. Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia. Int J Exp Pathol. 2011 Feb; 92(1):50-6. Dahi S, Karliner JS, Sarkar R, Lovett DH. PMID: 21039989; PMCID: PMC3052756.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    48. YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis. Biochem Biophys Res Commun. 2010 Jul 30; 398(3):482-8. Lovett DH, Cheng S, Cape L, Pollock AS, Mertens PR. PMID: 20599698; PMCID: PMC2925540.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    49. Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy. Biochem Biophys Res Commun. 2010 May 28; 396(2):219-23. Liu X, Manzano G, Lovett DH, Kim HT. PMID: 20398633.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cells. Reprod Biol Endocrinol. 2009 May 09; 7:41. Goldman S, Lovett DH, Shalev E. PMID: 19426551; PMCID: PMC2687445.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    51. Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease. Cardiovasc Pathol. 2009 Sep-Oct; 18(5):253-61. Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH. PMID: 18835790; PMCID: PMC3367668.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    52. Associations of interleukin-6, C-reactive protein and serum amyloid A with mortality in haemodialysis patients. Nephrology (Carlton). 2008 Oct; 13(7):593-600. Wetmore JB, Lovett DH, Hung AM, Cook-Wiens G, Mahnken JD, Sen S, Johansen KL. PMID: 18826487; PMCID: PMC3375899.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    53. Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis. Spine (Phila Pa 1976). 2008 Aug 01; 33(17):E576-9. Dang AB, Tay BK, Kim HT, Nauth A, Alfonso-Jaume MA, Lovett DH. PMID: 18670324.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    54. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H205-12. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. PMID: 17965283; PMCID: PMC3372085.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    55. Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Biochem Biophys Res Commun. 2007 Jun 22; 358(1):189-95. Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS. PMID: 17475219; PMCID: PMC3423089.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    56. Regulation of MMP-2 gene transcription in dermal wounds. J Invest Dermatol. 2007 Jul; 127(7):1762-7. Jansen PL, Rosch R, Jansen M, Binnebösel M, Junge K, Alfonso-Jaume A, Klinge U, Lovett DH, Mertens PR. PMID: 17344928.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    57. Polymeric meshes induce zonal regulation of matrix metalloproteinase-2 gene expression by macrophages and fibroblasts. FASEB J. 2007 Apr; 21(4):1047-57. Jansen PL, Kever M, Rosch R, Krott E, Jansen M, Alfonso-Jaume A, Dooley S, Klinge U, Lovett DH, Mertens PR. PMID: 17215487.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    58. Biomaterials: Disturbing Factors in Cell Cross-Talk and Gene Regulation. Recurrent Hernia. 2007 Jan 1; 63-67. Lynen-Jansen LP, Klinge KU, Lovett LD, Mertens MP. .
      View in: Publisher Site   Mentions:
    59. Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1847-60. Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH. PMID: 17158653.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    60. Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. FASEB J. 2006 Sep; 20(11):1898-900. Cheng S, Pollock AS, Mahimkar R, Olson JL, Lovett DH. PMID: 16891619.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
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    69. Interleukin-1 gene cluster polymorphisms predict risk of ESRD. Kidney Int. 2005 Jul; 68(1):278-84. Wetmore JB, Hung AM, Lovett DH, Sen S, Quershy O, Johansen KL. PMID: 15954918.
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    70. Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis. Genes Immun. 2005 May; 6(3):217-24. Parsa A, Lovett DH, Peden EA, Zhu L, Seldin MF, Criswell LA. PMID: 15789057.
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    71. The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins. Biochem J. 2005 Jan 15; 385(Pt 2):461-8. Mahimkar RM, Visaya O, Pollock AS, Lovett DH. PMID: 15361064; PMCID: PMC1134717.
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    72. Alloplastische Netzmaterialien induzieren die MMP-2 Promotoraktivität — Ergebnisse aus dem transgenen Mausmodell. Chirurgisches Forum 2005. 2005 Jan 1; 34:381-382. Jansen JP, Jansen JM, Hungol HM, Krott KE, Lovett LD, Mertens MP, Klinge KU. .
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    74. P53, YB-1 and the AP-1 family of transcription factors mediate MMP-2 transcription induced by skeletal muscle ischemia. Journal of the American College of Surgeons. 2004 Sep 1; 199(3):103. Sarkar SR, Lee LJ, Mahimkar MR, Lovett LD. .
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    76. Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol. 2003 Jun; 162(6):1937-49. Cheng S, Lovett DH. PMID: 12759250; PMCID: PMC1868144.
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    77. Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness. J Biol Chem. 2003 Jun 06; 278(23):20490-9. Harendza S, Lovett DH, Panzer U, Lukacs Z, Kuhnl P, Stahl RA. PMID: 12657623.
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    78. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Biochem J. 2003 Feb 01; 369(Pt 3):485-96. Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH. PMID: 12371906; PMCID: PMC1223099.
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    79. The prodomain of interleukin 1alpha interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells. FASEB J. 2003 Feb; 17(2):203-13. Pollock AS, Turck J, Lovett DH. PMID: 12554699.
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    80. Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Biochem J. 2002 Sep 15; 366(Pt 3):807-16. Cheng S, Alfonso-Jaume MA, Mertens PR, Lovett DH. PMID: 12010125; PMCID: PMC1222814.
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    83. Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. J Biol Chem. 2002 May 24; 277(21):19206-12. Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC. PMID: 11884411.
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    86. Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney. J Am Soc Nephrol. 2000 Apr; 11(4):595-603. Mahimkar RM, Baricos WH, Visaya O, Pollock AS, Lovett DH. PMID: 10752518.
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    89. Regulated expression of matrix metalloproteinases and TIMP in nephrogenesis. Dev Dyn. 1998 Sep; 213(1):121-9. Tanney DC, Feng L, Pollock AS, Lovett DH. PMID: 9733107.
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    92. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):508-13. Stevenson FT, Turck J, Locksley RM, Lovett DH. PMID: 9012814; PMCID: PMC19543.
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    93. Pharmacological inhibition of gelatinase B induction and tumor cell invasion. Int J Cancer. 1996 Aug 07; 67(4):523-31. McMillan JI, Weeks R, West JW, Bursten S, Rice GC, Lovett DH. PMID: 8759612.
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    95. Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy. J Clin Invest. 1996 Feb 15; 97(4):1094-101. McMillan JI, Riordan JW, Couser WG, Pollock AS, Lovett DH. PMID: 8613533; PMCID: PMC507157.
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    96. Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells. J Biol Chem. 1995 Aug 11; 270(32):18786-96. Harendza S, Pollock AS, Mertens PR, Lovett DH. PMID: 7642529.
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    97. Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest. 1995 Aug; 96(2):953-64. Lee LK, Meyer TW, Pollock AS, Lovett DH. PMID: 7635988; PMCID: PMC185283.
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    98. Immunologic glomerular disease--new prospects for specific therapy. West J Med. 1994 May; 160(5):481-2. Lovett DH. PMID: 8048244; PMCID: PMC1022505.
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    99. Role of oxidants and proteases in glomerular injury. Kidney Int. 1994 Feb; 45(2):352-9. Johnson RJ, Lovett D, Lehrer RI, Couser WG, Klebanoff SJ. PMID: 8164419.
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    100. Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J Biol Chem. 1994 Jan 21; 269(3):2032-40. Gaire M, Magbanua Z, McDonnell S, McNeil L, Lovett DH, Matrisian LM. PMID: 8294454.
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    101. Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase. Am J Pathol. 1994 Jan; 144(1):82-94. Marti HP, Lee L, Kashgarian M, Lovett DH. PMID: 8291614; PMCID: PMC1887110.
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    102. In vivo gene transfer, Koch's postulates, and renal disease. J Clin Invest. 1993 Dec; 92(6):2568. Johnson RJ, Lovett D. PMID: 8254014; PMCID: PMC288451.
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    103. Asymmetric origins of the mature glomerular basement membrane. J Cell Physiol. 1993 Oct; 157(1):169-77. Lee LK, Pollock AS, Lovett DH. PMID: 8408235.
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    104. The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):7245-9. Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH. PMID: 8346241; PMCID: PMC47113.
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    105. Homology cloning of rat 72 kDa type IV collagenase: cytokine and second-messenger inducibility in glomerular mesangial cells. Biochem J. 1993 Apr 15; 291 ( Pt 2):441-6. Marti HP, McNeil L, Davies M, Martin J, Lovett DH. PMID: 7916617; PMCID: PMC1132545.
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    107. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. J Exp Med. 1992 Oct 01; 176(4):1053-62. Stevenson FT, Bursten SL, Locksley RM, Lovett DH. PMID: 1402651; PMCID: PMC2119375.
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    108. Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms. J Cell Physiol. 1992 Aug; 152(2):223-31. Stevenson FT, Torrano F, Locksley RM, Lovett DH. PMID: 1639857.
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    109. Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1. Biochem J. 1992 Aug 01; 285 ( Pt 3):899-905. Marti HP, McNeil L, Thomas G, Davies M, Lovett DH. PMID: 1497627; PMCID: PMC1132880.
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    111. Expression of phosphoenolpyruvate carboxykinase (PEPCK) chimeras in renal epithelial cells. Retention of appropriate physiological responsiveness using enhancerless retroviral vectors. Biochem J. 1992 Jun 15; 284 ( Pt 3):725-32. Pollock AS, Lovett DH. PMID: 1377912; PMCID: PMC1132599.
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    112. Glomerular epithelial cells secrete a glomerular basement membrane-degrading metalloproteinase. J Am Soc Nephrol. 1992 Mar; 2(9):1388-97. Johnson R, Yamabe H, Chen YP, Campbell C, Gordon K, Baker P, Lovett D, Couser WG. PMID: 1627762.
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    113. Proteinases and glomerular matrix turnover. Kidney Int. 1992 Mar; 41(3):671-8. Davies M, Martin J, Thomas GJ, Lovett DH. PMID: 1573845.
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    115. Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells. J Biol Chem. 1991 Nov 05; 266(31):20732-43. Bursten SL, Harris WE, Bomsztyk K, Lovett D. PMID: 1657935.
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    118. Particles from dialysis tubing stimulate interleukin-1 secretion by macrophages. Nephrol Dial Transplant. 1990; 5(3):208-13. Bommer J, Weinreich T, Lovett DH, Bouillon R, Ritz E, Gemsa D. PMID: 2113649.
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    119. Human mesangial cells secrete a GBM-degrading neutral proteinase and a specific inhibitor. Kidney Int. 1989 Nov; 36(5):790-801. Martin J, Davies M, Thomas G, Lovett DH. PMID: 2559235.
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    120. Characterization of the interleukin-1-induced tyrosine phosphorylation of a 41-kDa plasma membrane protein of the human tumor cell line K 562. Eur J Biochem. 1989 Mar 15; 180(2):343-50. Martin M, Lovett DH, Szamel M, Resch K. PMID: 2784384.
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    122. Activation of glomerular mesangial cells by gram-negative bacterial cell wall components. Am J Pathol. 1988 Dec; 133(3):472-84. Lovett DH, Bursten SL, Gemsa D, Bessler W, Resch K, Ryan JL. PMID: 3059803; PMCID: PMC1880810.
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    123. Insulin and insulin-like growth factor I binding to cultured rat glomerular mesangial cells. Endocrinology. 1988 Nov; 123(5):2432-9. Abrass CK, Raugi GJ, Gabourel LS, Lovett DH. PMID: 3049050.
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    124. Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors. J Clin Invest. 1988 Nov; 82(5):1479-88. Bursten SL, Locksley RM, Ryan JL, Lovett DH. PMID: 3263392; PMCID: PMC442712.
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    125. Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells. J Clin Invest. 1988 Jul; 82(1):115-22. Lovett DH, Larsen A. PMID: 3260603; PMCID: PMC303484.
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    126. Interleukin 1 and the glomerular mesangium. III. IL-1-dependent stimulation of mesangial cell protein kinase activity. Kidney Int. 1988 Jul; 34(1):26-35. Lovett DH, Martin M, Bursten S, Szamel M, Gemsa D, Resch K. PMID: 3262785.
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    137. Macrophage cytotoxicity: interleukin 1 as a mediator of tumor cytostasis. J Immunol. 1986 Jan; 136(1):340-7. Lovett D, Kozan B, Hadam M, Resch K, Gemsa D. PMID: 2999248.
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    141. Production of an endogenous pyrogen by glomerular mesangial cells. J Immunol. 1985 Feb; 134(2):670-2. Lovett DH, Sterzel RB, Ryan JL, Atkins E. PMID: 3871212.
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    142. Stimulation of rat mesangial cell proliferation by macrophage interleukin 1. J Immunol. 1983 Dec; 131(6):2830-6. Lovett DH, Ryan JL, Sterzel RB. PMID: 6605992.
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    143. A thymocyte-activating factor derived from glomerular mesangial cells. J Immunol. 1983 Apr; 130(4):1796-801. Lovett DH, Ryan JL, Sterzel RB. PMID: 6601138.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    144. Neutral proteinase activity produced in vitro by cells of the glomerular mesangium. Kidney Int. 1983 Feb; 23(2):342-9. Lovett DH, Sterzel RB, Kashgarian M, Ryan JL. PMID: 6405073.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    145. The mesangium and glomerulonephritis. Klin Wochenschr. 1982 Sep 15; 60(18):1077-94. Sterzel RB, Lovett DH, Stein HD, Kashgarian M. PMID: 7144055.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    146. Lysosomal enzymes in glomerular cells of the rat. Am J Pathol. 1982 May; 107(2):161-6. Lovett DH, Ryan JL, Kashgarian M, Sterzel RB. PMID: 6282126; PMCID: PMC1916002.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    147. Angioimmunoblastic lymphadenopathy evolution to a Burkitt-like lymphoma. Am J Med. 1979 Aug; 67(2):317-24. Mazur EM, Lovett DH, Enriquez RE, Breg WR, Papac RJ. PMID: 313708.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
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