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Kayarat Nair, PhD

Title(s)Assistant Professor, Ophthalmology
SchoolSchool of Medicine
Address10 Koret Way
San Francisco CA 94143
Phone415-476-0461
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    Collapse Biography 
    Collapse Education and Training
    HHMI/The Jackson LaboratoryPostdoctoral
    University of Mumbai, IndiaPhD

    Collapse Overview 
    Collapse Overview
    Sai Nair, PhD is an Assistant Professor of Ophthalmology and Anatomy. He obtained a PhD in Biochemistry from the University of Mumbai, India. During his PhD, Dr. Nair studied the role of cell surface receptors in regulation of neutrophil effector functions. Dr. Nair received his postdoctoral training in Dr. Simon John’s laboratory at The Jackson Laboratory. He worked extensively on characterizing both spontaneous and chemically induced mouse mutants that recapitulate features of human glaucoma. He has identified genes contributing to glaucoma, generated new mouse models of human glaucoma and have utilized them to gain insight into the underlying pathological causes of the disease. The overall goal of his laboratory is to identify the specific genetic risk factors conferring susceptibility towards ocular diseases with a major focus on glaucoma and uncover their mechanisms of action using state of art genetics and genomics techniques. A major aim is to functionally validate candidate glaucoma genes identified through genetic association studies (both rare and common variants) and to uncover the underlying pathogenic processes and identify targets with therapeutic potential. His laboratory employs a multi-disciplinary approach by integrating the use of animal models, genetics, genomics, molecular biology, cell-biology and physiology based experiments to gain mechanistic insight into disease pathogenesis.

    Collapse Research 
    Collapse Research Activities and Funding
    Novel Genetic Mouse Model of Early-Onset Glaucoma
    BrightFocus Foundation Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    The Role of Refractive Error in the Etiology of Glaucoma
    NEI/NIH R01 EY027004Jul 1, 2017 - Jun 30, 2021
    Role: Co-Investigator
    Determining Molecular and Cellular Mechanisms of Glaucoma
    NIH/NEI R01EY022891Feb 1, 2013 - Jan 31, 2018
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure. Dis Model Mech. 2020 05 29; 13(5). Labelle-Dumais C, Pyatla G, Paylakhi S, Tolman NG, Hameed S, Seymens Y, Dang E, Mandal AK, Senthil S, Khanna RC, Kabra M, Kaur I, John SWM, Chakrabarti S, Nair KS. PMID: 32152063.
      View in: PubMed   Mentions:    Fields:    
    2. A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun. 2018 06 11; 9(1):2278. Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E. PMID: 29891935.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    3. Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error. PLoS Genet. 2018 03; 14(3):e1007244. Paylakhi S, Labelle-Dumais C, Tolman NG, Sellarole MA, Seymens Y, Saunders J, Lakosha H, deVries WN, Orr AC, Topilko P, John SW, Nair KS. PMID: 29529029.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Nat Commun. 2017 12 13; 8(1):2108. Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E. PMID: 29235454.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    5. YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech. 2016 08 01; 9(8):863-71. Nair KS, Cosma M, Raghupathy N, Sellarole MA, Tolman NG, de Vries W, Smith RS, John SW. PMID: 27483353.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities. Exp Eye Res. 2015 Dec; 141:42-56. Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT. PMID: 26116903.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    7. Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice. BMC Genet. 2014 Mar 28; 15:42. Nair KS, Barbay J, Smith RS, Masli S, John SW. PMID: 24678736.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    8. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014 Mar; 10(3):e1004089. Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair KS, Cheng CY, Xu L, George R, Tan D, Abu-Amero K, Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin LS, Ho CL, Tham CC, Soto I, Chew PT, Wong HT, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VH, Ting SM, Li Y, Wang YX, Li Z, Lavanya R, Wu RY, Zheng YF, Su DH, Loon SC, Yong VK, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia KS, Kumaramanickavel G, Wong TT, How AC, Chau TN, Simmons CP, Bei JX, Zeng YX, Bhattacharya SS, Zhang M, Tan DT, Teo YY, Al-Obeidan SA, Hon DN, Tai ES, Saw SM, Foster PJ, Vijaya L, Jonas JB, Wong TY, John SW, Pang CP, Vithana EN, Wang N, Aung T. PMID: 24603532.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    9. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011 Jun; 43(6):579-84. Nair KS, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW. PMID: 21532570.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    10. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25; 331(6024):1571-6. Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL. PMID: 21436445.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    11. Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization. Biochem J. 2009 Feb 01; 417(3):803-12. Rosenzweig DH, Nair KS, Levay K, Peshenko IV, Crabb JW, Dizhoor AM, Slepak VZ. PMID: 18840097.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet. 2008 Apr 10; 9:30. Anderson MG, Nair KS, Amonoo LA, Mehalow A, Trantow CM, Masli S, John SW. PMID: 18402690.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. J Neurosci. 2007 May 16; 27(20):5484-94. Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. PMID: 17507570.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    14. Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. J Mol Biol. 2007 Apr 27; 368(2):375-87. Hanson SM, Cleghorn WM, Francis DJ, Vishnivetskiy SA, Raman D, Song X, Nair KS, Slepak VZ, Klug CS, Gurevich VV. PMID: 17359998.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    15. Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 2005 May 19; 46(4):555-67. Nair KS, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ. PMID: 15944125.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    16. The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors. Invest Ophthalmol Vis Sci. 2005 Jan; 46(1):383-9. Nair KS, Mendez A, Blumer JB, Rosenzweig DH, Slepak VZ. PMID: 15623799.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors. J Biol Chem. 2004 Sep 24; 279(39):41240-8. Nair KS, Hanson SM, Kennedy MJ, Hurley JB, Gurevich VV, Slepak VZ. PMID: 15272005.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    18. Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors. Curr Biol. 2002 Mar 05; 12(5):421-5. Nair KS, Balasubramanian N, Slepak VZ. PMID: 11882295.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    19. Adhesion of neutrophils to fibronectin: role of the cd66 antigens. Cell Immunol. 2001 Mar 15; 208(2):96-106. Nair KS, Zingde SM. PMID: 11333142.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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