Kayarat Nair, PhD

Title(s)Assistant Professor, Ophthalmology
SchoolSchool of Medicine
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    HHMI/The Jackson LaboratoryPostdoctoral
    University of Mumbai, IndiaPhD

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    Sai Nair, PhD is an Assistant Professor of Ophthalmology and Anatomy. He obtained a PhD in Biochemistry from the University of Mumbai, India. During his PhD, Dr. Nair studied the role of cell surface receptors in regulation of neutrophil effector functions. Dr. Nair received his postdoctoral training in Dr. Simon John’s laboratory at The Jackson Laboratory. He worked extensively on characterizing both spontaneous and chemically induced mouse mutants that recapitulate features of human glaucoma. He has identified genes contributing to glaucoma, generated new mouse models of human glaucoma and have utilized them to gain insight into the underlying pathological causes of the disease. In 2013, he joined the UCSF faculty where his lab studies the role of genetic factors contributing to ocular diseases with a major focus on glaucoma. His laboratory employs a multi-disciplinary approach by integrating the use of animal models, genetics, genomics, molecular biology, cell-biology and physiology based experiments to gain mechanistic insight into disease pathogenesis.

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    The Role of Refractive Error in the Etiology of Glaucoma
    NEI/NIH R01 EY027004Jul 1, 2017 - Jun 30, 2021
    Role: Co-Investigator
    Determining Molecular and Cellular Mechanisms of Glaucoma
    NIH/NEI R01EY022891Feb 1, 2013 - Jan 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E. A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun. 2018 06 11; 9(1):2278. PMID: 29891935.
      View in: PubMed
    2. Paylakhi S, Labelle-Dumais C, Tolman NG, Sellarole MA, Seymens Y, Saunders J, Lakosha H, deVries WN, Orr AC, Topilko P, John SW, Nair KS. Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error. PLoS Genet. 2018 03; 14(3):e1007244. PMID: 29529029.
      View in: PubMed
    3. Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E. A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Nat Commun. 2017 12 13; 8(1):2108. PMID: 29235454.
      View in: PubMed
    4. Nair KS, Cosma M, Raghupathy N, Sellarole MA, Tolman NG, de Vries W, Smith RS, John SW. YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech. 2016 08 01; 9(8):863-71. PMID: 27483353.
      View in: PubMed
    5. Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT. Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities. Exp Eye Res. 2015 Dec; 141:42-56. PMID: 26116903; PMCID: PMC4628898 [Available on 12/01/16].
    6. Nair KS, Barbay J, Smith RS, Masli S, John SW. Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice. BMC Genet. 2014 Mar 28; 15:42. PMID: 24678736; PMCID: PMC3974199.
    7. Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair KS, Cheng CY, Xu L, George R, Tan D, Abu-Amero K, Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin LS, Ho CL, Tham CC, Soto I, Chew PT, Wong HT, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VH, Ting SM, Li Y, Wang YX, Li Z, Lavanya R, Wu RY, Zheng YF, Su DH, Loon SC, Yong VK, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia KS, Kumaramanickavel G, Wong TT, How AC, Chau TN, Simmons CP, Bei JX, Zeng YX, Bhattacharya SS, Zhang M, Tan DT, Teo YY, Al-Obeidan SA, Hon DN, Tai ES, Saw SM, Foster PJ, Vijaya L, Jonas JB, Wong TY, John SW, Pang CP, Vithana EN, Wang N, Aung T. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014 Mar; 10(3):e1004089. PMID: 24603532; PMCID: PMC3945113.
    8. Nair KS, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011 Jun; 43(6):579-84. PMID: 21532570; PMCID: PMC4388060.
    9. Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25; 331(6024):1571-6. PMID: 21436445.
      View in: PubMed
    10. Rosenzweig DH, Nair KS, Levay K, Peshenko IV, Crabb JW, Dizhoor AM, Slepak VZ. Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization. Biochem J. 2009 Feb 01; 417(3):803-12. PMID: 18840097; PMCID: PMC3312023.
    11. Anderson MG, Nair KS, Amonoo LA, Mehalow A, Trantow CM, Masli S, John SW. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet. 2008 Apr 10; 9:30. PMID: 18402690; PMCID: PMC2373794.
    12. Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. J Neurosci. 2007 May 16; 27(20):5484-94. PMID: 17507570; PMCID: PMC2655354.
    13. Hanson SM, Cleghorn WM, Francis DJ, Vishnivetskiy SA, Raman D, Song X, Nair KS, Slepak VZ, Klug CS, Gurevich VV. Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. J Mol Biol. 2007 Apr 27; 368(2):375-87. PMID: 17359998; PMCID: PMC1904837.
    14. Nair KS, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ. Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 2005 May 19; 46(4):555-67. PMID: 15944125; PMCID: PMC2752952.
    15. Nair KS, Mendez A, Blumer JB, Rosenzweig DH, Slepak VZ. The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors. Invest Ophthalmol Vis Sci. 2005 Jan; 46(1):383-9. PMID: 15623799.
      View in: PubMed
    16. Nair KS, Hanson SM, Kennedy MJ, Hurley JB, Gurevich VV, Slepak VZ. Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors. J Biol Chem. 2004 Sep 24; 279(39):41240-8. PMID: 15272005.
      View in: PubMed
    17. Nair KS, Balasubramanian N, Slepak VZ. Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors. Curr Biol. 2002 Mar 05; 12(5):421-5. PMID: 11882295.
      View in: PubMed
    18. Nair KS, Zingde SM. Adhesion of neutrophils to fibronectin: role of the cd66 antigens. Cell Immunol. 2001 Mar 15; 208(2):96-106. PMID: 11333142.
      View in: PubMed