Kayarat Nair, PhD

Title(s)Assistant Professor, Ophthalmology
SchoolSchool of Medicine
Address10 Koret Way
San Francisco CA 94143
Phone415-476-0461
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    Collapse Biography 
    Collapse Education and Training
    HHMI/The Jackson LaboratoryPostdoctoral
    University of Mumbai, IndiaPhD

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    Collapse Overview
    Sai Nair, PhD is an Assistant Professor of Ophthalmology and Anatomy. He obtained a PhD in Biochemistry from the University of Mumbai, India. During his PhD, Dr. Nair studied the role of cell surface receptors in regulation of neutrophil effector functions. Dr. Nair received his postdoctoral training in Dr. Simon John’s laboratory at The Jackson Laboratory. He worked extensively on characterizing both spontaneous and chemically induced mouse mutants that recapitulate features of human glaucoma. He has identified genes contributing to glaucoma, generated new mouse models of human glaucoma and have utilized them to gain insight into the underlying pathological causes of the disease. The overall goal of his laboratory is to identify the specific genetic risk factors conferring susceptibility towards ocular diseases with a major focus on glaucoma and uncover their mechanisms of action using state of art genetics and genomics techniques. A major aim is to functionally validate candidate glaucoma genes identified through genetic association studies (both rare and common variants) and to uncover the underlying pathogenic processes and identify targets with therapeutic potential. His laboratory employs a multi-disciplinary approach by integrating the use of animal models, genetics, genomics, molecular biology, cell-biology and physiology based experiments to gain mechanistic insight into disease pathogenesis.
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    Collapse Research Activities and Funding
    Novel Genetic Mouse Model of Early-Onset Glaucoma
    BrightFocus Foundation Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    The Role of Refractive Error in the Etiology of Glaucoma
    NEI/NIH R01 EY027004Jul 1, 2017 - Jun 30, 2022
    Role: Co-Investigator
    Determining Molecular and Cellular Mechanisms of Glaucoma
    NIH R01EY022891Feb 1, 2013 - Jan 31, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Nat Commun. 2021 08 12; 12(1):4877. Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Grimm SA, Sutherland C, Badea A, Johnson GA, Zhao Y, Yin J, Okamoto K, Clark G, Borrás T, Zode G, Kizhatil K, Chakrabarti S, John SWM, Jorgenson E, Jetten AM. PMID: 34385434.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. bioRxiv. 2021. Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Sutherland C, Grimm SA, Badea A, Zhao Y, Yin J, Okamoto K, Clark G, Borras T, Zode G, Chakrabarti S, Kizhatil K, John SW, Jorgenson E, and Jetten AM. View Publication.
    3. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Nat Commun. 2021 06 14; 12(1):3595. Choquet H, Melles RB, Anand D, Yin J, Cuellar-Partida G, Wang W, 23andMe Research Team , Hoffmann TJ, Nair KS, Hysi PG, Lachke SA, Jorgenson E. PMID: 34127677.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation. PLoS Genet. 2021 03; 17(3):e1009458. Koli S, Labelle-Dumais C, Zhao Y, Paylakhi S, Nair KS. PMID: 33755662.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun. 2021 02 24; 12(1):1258. Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segrè AV, Rouhana JM, Hamel AR, Igo RP, Choquet H, Qassim A, Josyula NS, Cooke Bailey JN, Bonnemaijer PWM, Iglesias A, Siggs OM, Young TL, Vitart V, Thiadens AAHJ, Karjalainen J, Uebe S, Melles RB, Nair KS, Luben R, Simcoe M, Amersinghe N, Cree AJ, Hohn R, Poplawski A, Chen LJ, Rong SS, Aung T, Vithana EN, NEIGHBORHOOD consortium , ANZRAG consortium , Biobank Japan project , FinnGen study , UK Biobank Eye and Vision Consortium , GIGA study group , 23 and Me Research Team , Tamiya G, Shiga Y, Yamamoto M, Nakazawa T, Currant H, Birney E, Wang X, Auton A, Lupton MK, Martin NG, Ashaye A, Olawoye O, Williams SE, Akafo S, Ramsay M, Hashimoto K, Kamatani Y, Akiyama M, Momozawa Y, Foster PJ, Khaw PT, Morgan JE, Strouthidis NG, Kraft P, Kang JH, Pang CP, Pasutto F, Mitchell P, Lotery AJ, Palotie A, van Duijn C, Haines JL, Hammond C, Pasquale LR, Klaver CCW, Hauser M, Khor CC, Mackey DA, Kubo M, Cheng CY, Craig JE, MacGregor S, Wiggs JL. PMID: 33627673.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    6. Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice. Dis Model Mech. 2021 02 19; 14(2). Tolman NG, Balasubramanian R, Macalinao DG, Kearney AL, MacNicoll KH, Montgomery CL, de Vries WN, Jackson IJ, Cross SH, Kizhatil K, Nair KS, John SWM. PMID: 33462143.
      View in: PubMed   Mentions: 2     Fields:    
    7. A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness. Commun Biol. 2020 06 11; 3(1):301. Choquet H, Melles RB, Yin J, Hoffmann TJ, Thai KK, Kvale MN, Banda Y, Hardcastle AJ, Tuft SJ, Glymour MM, Schaefer C, Risch N, Nair KS, Hysi PG, Jorgenson E. PMID: 32528159.
      View in: PubMed   Mentions:
    8. Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure. Dis Model Mech. 2020 05 29; 13(5). Labelle-Dumais C, Pyatla G, Paylakhi S, Tolman NG, Hameed S, Seymens Y, Dang E, Mandal AK, Senthil S, Khanna RC, Kabra M, Kaur I, John SWM, Chakrabarti S, Nair KS. PMID: 32152063.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun. 2018 06 11; 9(1):2278. Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E. PMID: 29891935.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    10. Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error. PLoS Genet. 2018 03; 14(3):e1007244. Paylakhi S, Labelle-Dumais C, Tolman NG, Sellarole MA, Seymens Y, Saunders J, Lakosha H, deVries WN, Orr AC, Topilko P, John SW, Nair KS. PMID: 29529029.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Nat Commun. 2017 12 13; 8(1):2108. Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E. PMID: 29235454.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    12. YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech. 2016 08 01; 9(8):863-71. Nair KS, Cosma M, Raghupathy N, Sellarole MA, Tolman NG, de Vries W, Smith RS, John SW. PMID: 27483353.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities. Exp Eye Res. 2015 Dec; 141:42-56. Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT. PMID: 26116903.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    14. Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice. BMC Genet. 2014 Mar 28; 15:42. Nair KS, Barbay J, Smith RS, Masli S, John SW. PMID: 24678736.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014 Mar; 10(3):e1004089. Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair KS, Cheng CY, Xu L, George R, Tan D, Abu-Amero K, Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin LS, Ho CL, Tham CC, Soto I, Chew PT, Wong HT, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VH, Ting SM, Li Y, Wang YX, Li Z, Lavanya R, Wu RY, Zheng YF, Su DH, Loon SC, Yong VK, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia KS, Kumaramanickavel G, Wong TT, How AC, Chau TN, Simmons CP, Bei JX, Zeng YX, Bhattacharya SS, Zhang M, Tan DT, Teo YY, Al-Obeidan SA, Hon DN, Tai ES, Saw SM, Foster PJ, Vijaya L, Jonas JB, Wong TY, John SW, Pang CP, Vithana EN, Wang N, Aung T. PMID: 24603532.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    16. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011 Jun; 43(6):579-84. Nair KS, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW. PMID: 21532570.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    17. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25; 331(6024):1571-6. Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL. PMID: 21436445.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    18. Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization. Biochem J. 2009 Feb 01; 417(3):803-12. Rosenzweig DH, Nair KS, Levay K, Peshenko IV, Crabb JW, Dizhoor AM, Slepak VZ. PMID: 18840097.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet. 2008 Apr 10; 9:30. Anderson MG, Nair KS, Amonoo LA, Mehalow A, Trantow CM, Masli S, John SW. PMID: 18402690.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    20. Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. J Neurosci. 2007 May 16; 27(20):5484-94. Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. PMID: 17507570.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    21. Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. J Mol Biol. 2007 Apr 27; 368(2):375-87. Hanson SM, Cleghorn WM, Francis DJ, Vishnivetskiy SA, Raman D, Song X, Nair KS, Slepak VZ, Klug CS, Gurevich VV. PMID: 17359998.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    22. Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 2005 May 19; 46(4):555-67. Nair KS, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ. PMID: 15944125.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    23. The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors. Invest Ophthalmol Vis Sci. 2005 Jan; 46(1):383-9. Nair KS, Mendez A, Blumer JB, Rosenzweig DH, Slepak VZ. PMID: 15623799.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors. J Biol Chem. 2004 Sep 24; 279(39):41240-8. Nair KS, Hanson SM, Kennedy MJ, Hurley JB, Gurevich VV, Slepak VZ. PMID: 15272005.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    25. Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors. Curr Biol. 2002 Mar 05; 12(5):421-5. Nair KS, Balasubramanian N, Slepak VZ. PMID: 11882295.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    26. Adhesion of neutrophils to fibronectin: role of the cd66 antigens. Cell Immunol. 2001 Mar 15; 208(2):96-106. Nair KS, Zingde SM. PMID: 11333142.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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