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Kayarat Nair, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentOphthalmology
Address10 Koret Way
San Francisco CA 94143
Phone415-476-0461
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    Collapse Biography 
    Collapse Education and Training
    University of Mumbai, IndiaPhD2002
    HHMI/The Jackson LaboratoryPostdoctoral2008

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    Collapse Overview
    Sai Nair, PhD is an Assistant Professor of Ophthalmology and Anatomy. He obtained a PhD in Biochemistry from the University of Mumbai, India. During his PhD, Dr. Nair studied the role of cell surface receptors in regulation of neutrophil effector functions. Dr. Nair received his postdoctoral training in Dr. Simon John’s laboratory at The Jackson Laboratory. He worked extensively on characterizing both spontaneous and chemically induced mouse mutants that recapitulate features of human glaucoma. He has identified genes contributing to glaucoma, generated new mouse models of human glaucoma and have utilized them to gain insight into the underlying pathological causes of the disease. In 2013, he joined the UCSF faculty where his lab studies the role of genetic factors contributing to ocular diseases with a major focus on glaucoma. His laboratory employs a multi-disciplinary approach by integrating the use of animal models, genetics, genomics, molecular biology, cell-biology and physiology based experiments to gain mechanistic insight into disease pathogenesis.


    Collapse Research 
    Collapse Research Activities and Funding
    Determining Molecular and Cellular Mechanisms of Glaucoma
    NIH/NEI R01EY022891Feb 1, 2013 - Jan 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nair K, Cosma M, Raghupathy N, Sellarole MA, Tolman NG, de Vries W, Smith RS, John SW. YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech. 2016 Aug 1; 9(8):863-71. PMID: 27483353.
      View in: PubMed
    2. Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair K, Anderson MG, John SW, Howell GR, Libby RT. Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities. Exp Eye Res. 2015 Dec; 141:42-56. PMID: 26116903; PMCID: PMC4628898 [Available on 12/01/16].
    3. Nair K, Barbay J, Smith RS, Masli S, John SW. Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice. BMC Genet. 2014; 15:42. PMID: 24678736; PMCID: PMC3974199.
    4. Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair K, Cheng CY, Xu L, George R, Tan D, Abu-Amero K, Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin LS, Ho CL, Tham CC, Soto I, Chew PT, Wong HT, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VH, Ting SM, Li Y, Wang YX, Li Z, Lavanya R, Wu RY, Zheng YF, Su DH, Loon SC, Yong VK, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia KS, Kumaramanickavel G, Wong TT, How AC, Chau TN, Simmons CP, Bei JX, Zeng YX, Bhattacharya SS, Zhang M, Tan DT, Teo YY, Al-Obeidan SA, Hon do N, Tai ES, Saw SM, Foster PJ, Vijaya L, Jonas JB, Wong TY, John SW, Pang CP, Vithana EN, Wang N, Aung T. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014 Mar; 10(3):e1004089. PMID: 24603532; PMCID: PMC3945113.
    5. Nair K, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011 Jun; 43(6):579-84. PMID: 21532570; PMCID: PMC4388060.
    6. Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair K, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25; 331(6024):1571-6. PMID: 21436445; PMCID: PMC3279122.
    7. Rosenzweig DH, Nair K, Levay K, Peshenko IV, Crabb JW, Dizhoor AM, Slepak VZ. Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization. Biochem J. 2009 Feb 1; 417(3):803-12. PMID: 18840097; PMCID: PMC3312023.
    8. Anderson MG, Nair K, Amonoo LA, Mehalow A, Trantow CM, Masli S, John SW. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet. 2008; 9:30. PMID: 18402690; PMCID: PMC2373794.
    9. Rosenzweig DH, Nair K, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. J Neurosci. 2007 May 16; 27(20):5484-94. PMID: 17507570; PMCID: PMC2655354.
    10. Hanson SM, Cleghorn WM, Francis DJ, Vishnivetskiy SA, Raman D, Song X, Nair K, Slepak VZ, Klug CS, Gurevich VV. Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. J Mol Biol. 2007 Apr 27; 368(2):375-87. PMID: 17359998; PMCID: PMC1904837.
    11. Nair K, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ. Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 2005 May 19; 46(4):555-67. PMID: 15944125; PMCID: PMC2752952.
    12. Nair K, Mendez A, Blumer JB, Rosenzweig DH, Slepak VZ. The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors. Invest Ophthalmol Vis Sci. 2005 Jan; 46(1):383-9. PMID: 15623799.
      View in: PubMed
    13. Nair K, Hanson SM, Kennedy MJ, Hurley JB, Gurevich VV, Slepak VZ. Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors. J Biol Chem. 2004 Sep 24; 279(39):41240-8. PMID: 15272005.
      View in: PubMed
    14. Nair K, Balasubramanian N, Slepak VZ. Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors. Curr Biol. 2002 Mar 5; 12(5):421-5. PMID: 11882295.
      View in: PubMed
    15. Nair K, Zingde SM. Adhesion of neutrophils to fibronectin: role of the cd66 antigens. Cell Immunol. 2001 Mar 15; 208(2):96-106. PMID: 11333142.
      View in: PubMed
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