Loading...

Thomas Hoffmann, PhD

Title(s)Associate Professor, Epidemiology & Biostatistics
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-2475
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of Wisconsin MadisonBS06/2004Computer Science, Mathematics, Statistics
    Harvard UniversityAM06/2006Biostatistics
    Harvard UniversityPhD06/2009Biostatistics
    University of California San FranciscoPost-doc08/2011Biostatistics and Genetic Epidemiology

    Collapse Overview 
    Collapse Overview
    I have a broad background in statistics, genetics, and computer science, have been involved in a wide variety of theoretical and applied projects. My my applied work encompasses a wide variety of genetic association studies related to human health, including work on age-related hearing impairment, cardiovascular disease, and cancer. Driven by my applied research, my methodological work includes imputation, array design, rare variants, gene-environment interaction, and study design, and I have produced software packages that implement the methodology in these works so other researchers can freely use them.

    Collapse Research 
    Collapse Research Activities and Funding
    Sequencing not required: Imputing rare variants into a cohort of 100,000 on aging
    NIH/NIA R21AG046616Sep 30, 2013 - Jun 30, 2015
    Role: Principal Investigator
    Genome-wide Study of Hearing Impairment
    NIH/NIDCD K01DC013300Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness. Commun Biol. 2020 Jun 11; 3(1):301. Choquet H, Melles RB, Yin J, Hoffmann TJ, Thai KK, Kvale MN, Banda Y, Hardcastle AJ, Tuft SJ, Glymour MM, Schaefer C, Risch N, Nair KS, Hysi PG, Jorgenson E. PMID: 32528159.
      View in: PubMed   Mentions:
    2. Analysis of putative cis-regulatory elements regulating blood pressure variation. Hum Mol Genet. 2020 May 21. Nandakumar P, Lee D, Hoffmann TJ, Ehret GB, Arking D, Ranatunga D, Li M, Grove ML, Boerwinkle E, Schaefer C, Kwok PY, Iribarren C, Risch N, Chakravarti A. PMID: 32436959.
      View in: PubMed   Mentions:    Fields:    
    3. The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change. NPJ Genom Med. 2020; 5:1. Oni-Orisan A, Haldar T, Ranatunga DK, Medina MW, Schaefer C, Krauss RM, Iribarren C, Risch N, Hoffmann TJ. PMID: 31969989.
      View in: PubMed   Mentions:
    4. Using a genetic risk score to estimate the earliest age of Alzheimer's disease-related physiologic change in Body Mass Index. medRxiv. 2019 Dec 4; 19013441. Willa Brenowitz, Scott Zimmerman, Teresa Filshtein, Kristine Yaffe, Stefan Walter, Thomas Hoffmann, Eric Jorgenson, Rachel Whitmer, Maria Glymour. .
      View in: Publisher Site   Mentions:
    5. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. JAMA. 2019 11 05; 322(17):1682-1691. Hauser MA, Allingham RR, Aung T, Van Der Heide CJ, Taylor KD, Rotter JI, Wang SJ, Bonnemaijer PWM, Williams SE, Abdullahi SM, Abu-Amero KK, Anderson MG, Akafo S, Alhassan MB, Asimadu I, Ayyagari R, Bakayoko S, Nyamsi PB, Bowden DW, Bromley WC, Budenz DL, Carmichael TR, Challa P, Chen YI, Chuka-Okosa CM, Cooke Bailey JN, Costa VP, Cruz DA, DuBiner H, Ervin JF, Feldman RM, Flamme-Wiese M, Gaasterland DE, Garnai SJ, Girkin CA, Guirou N, Guo X, Haines JL, Hammond CJ, Herndon L, Hoffmann TJ, Hulette CM, Hydara A, Igo RP, Jorgenson E, Kabwe J, Kilangalanga NJ, Kizor-Akaraiwe N, Kuchtey RW, Lamari H, Li Z, Liebmann JM, Liu Y, Loos RJF, Melo MB, Moroi SE, Msosa JM, Mullins RF, Nadkarni G, Napo A, Ng MCY, Nunes HF, Obeng-Nyarkoh E, Okeke A, Okeke S, Olaniyi O, Olawoye O, Oliveira MB, Pasquale LR, Perez-Grossmann RA, Pericak-Vance MA, Qin X, Ramsay M, Resnikoff S, Richards JE, Schimiti RB, Sim KS, Sponsel WE, Svidnicki PV, Thiadens AAHJ, Uche NJ, van Duijn CM, de Vasconcellos JPC, Wiggs JL, Zangwill LM, Risch N, Milea D, Ashaye A, Klaver CCW, Weinreb RN, Ashley Koch AE, Fingert JH, Khor CC. PMID: 31688885.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis. Am J Respir Crit Care Med. 2019 11 01; 200(9):1154-1163. Ley B, Torgerson DG, Oldham JM, Adegunsoye A, Liu S, Li J, Elicker BM, Henry TS, Golden JA, Jones KD, Dressen A, Yaspan BL, Arron JR, Noth I, Hoffmann TJ, Wolters PJ. PMID: 31268371.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Author Correction: Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms. Nat Commun. 2019 Aug 28; 10(1):3948. Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS. PMID: 31462633.
      View in: PubMed   Mentions:    Fields:    
    8. Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts. J Allergy Clin Immunol. 2020 Jan; 145(1):192-198.e11. Abuabara K, You Y, Margolis DJ, Hoffmann TJ, Risch N, Jorgenson E. PMID: 31369801.
      View in: PubMed   Mentions:    Fields:    
    9. Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms. Nat Commun. 2019 07 15; 10(1):3107. Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS. PMID: 31308362.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. A genome-wide association study of prostate cancer in Latinos. Int J Cancer. 2020 04 01; 146(7):1819-1826. Du Z, Hopp H, Ingles SA, Huff C, Sheng X, Weaver B, Stern M, Hoffmann TJ, John EM, Van Den Eeden SK, Strom S, Leach RJ, Thompson IM, Witte JS, Conti DV, Haiman CA. PMID: 31226226.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. USING GENETIC INFORMATION TO IDENTIFY THE EARLIEST MANIFESTATIONS OF ALZHEIMER’S DISEASE: GENETIC RISK SCORE FOR ALZHEIMER’S DISEASE PREDICTS LOWER BMI BY AGE 58. Alzheimer's & Dementia. 2019 Jul 1; 15(7):p903. Willa D. Brenowitz, Teresa J. Filshtein, Kristine Yaffe, Stefan Walter, Thomas Hoffmann, Eric Jorgenson, Rachel A. Whitmer, Maria Glymour. .
      View in: Publisher Site   Mentions:
    12. Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort. Environmental Epidemiology. 2019 Jun 1; 3(3):e049. Stacey E. Alexeeff, Catherine A. Schaefer, Mark N. Kvale, Jun Shan, Elizabeth H. Blackburn, Neil Risch, Dilrini K. Ranatunga, Eric Jorgenson, Thomas J. Hoffmann, Lori C. Sakoda, Charles P. Quesenberry, Stephen K. Van Den Eeden. .
      View in: Publisher Site   Mentions:
    13. Reply to Liu et al.: Tissue specificity of SIM1 gene expression and erectile dysfunction. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3349-3350. Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK. PMID: 30755537.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. SU23 ASSOCIATIONS OF POLYGENIC RISK OF SCHIZOPHRENIA AND MAJOR DEPRESSION IN STUDIES OF BIPOLAR DISORDER AND MAJOR DEPRESSION. European Neuropsychopharmacology. 2019 Jan 1; 29:s899-s900. Cathy Schaefer, Khanh Thai, Eric Jorgenson, Yambazi Banda, Thomas Hoffmann, Mark Kvale, Neil Risch. .
      View in: Publisher Site   Mentions:
    15. Genetic variation in the SIM1 locus is associated with erectile dysfunction. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):11018-11023. Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK. PMID: 30297428.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort. Circ Genom Precis Med. 2018 09; 11(9):e002043. Oni-Orisan A, Hoffmann TJ, Ranatunga D, Medina MW, Jorgenson E, Schaefer C, Krauss RM, Iribarren C, Risch N. PMID: 30354326.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci. Genetics. 2018 10; 210(2):499-515. Hoffmann TJ, Choquet H, Yin J, Banda Y, Kvale MN, Glymour M, Schaefer C, Risch N, Jorgenson E. PMID: 30108127.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. EVALUATING REVERSE CAUSATION BETWEEN DEMENTIA AND HEARING IMPAIRMENT USING A GENETIC RISK SCORE FOR ALZHEIMER’S DISEASE. Alzheimer's & Dementia. 2018 Jul 1; 14(7):p1012-p1013. Willa D. Brenowitz, Teresa J. Filshtein, Thomas Hoffmann, Kristine Yaffe, Eric Jorgenson, Rachel A. Whitmer, Maria Glymour. .
      View in: Publisher Site   Mentions:
    19. A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun. 2018 06 11; 9(1):2278. Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E. PMID: 29891935.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. A large electronic-health-record-based genome-wide study of serum lipids. Nat Genet. 2018 03; 50(3):401-413. Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, Iribarren C, Risch N. PMID: 29507422.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Nat Commun. 2017 12 13; 8(1):2108. Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E. PMID: 29235454.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics. Cancer Epidemiol Biomarkers Prev. 2018 01; 27(1):75-85. Wu YH, Graff RE, Passarelli MN, Hoffman JD, Ziv E, Hoffmann TJ, Witte JS. PMID: 29150481.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. J Natl Cancer Inst. 2017 08 01; 109(8). Conti DV, Wang K, Sheng X, Bensen JT, Hazelett DJ, Cook MB, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Sanderson M, John EM, Park JY, Xu J, Stevens VL, Berndt SI, Huff CD, Wang Z, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Sellers TA, Yamoah K, Murphy AB, Crawford DC, Gapstur SM, Bush WS, Aldrich MC, Cussenot O, Petrovics G, Cullen J, Neslund-Dudas C, Stern MC, Jarai ZK, Govindasami K, Chokkalingam AP, Hsing AW, Goodman PJ, Hoffmann T, Drake BF, Hu JJ, Clark PE, Van Den Eeden SK, Blanchet P, Fowke JH, Casey G, Hennis AJM, Han Y, Lubwama A, Thompson IM, Leach R, Easton DF, Schumacher F, Van den Berg DJ, Gundell SM, Stram A, Wan P, Xia L, Pooler LC, Mohler JL, Fontham ETH, Smith GJ, Taylor JA, Srivastava S, Eeles RA, Carpten J, Kibel AS, Multigner L, Parent ME, Menegaux F, Cancel-Tassin G, Klein EA, Brureau L, Stram DO, Watya S, Chanock SJ, Witte JS, Blot WJ, Henderson BE, Haiman CA. PMID: 29117387.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children. Dev Psychopathol. 2018 02; 30(1):203-211. Wade M, Prime H, Hoffmann TJ, Schmidt LA, O'Connor TG, Jenkins JM. PMID: 28511728.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. Mol Psychiatry. 2017 09; 22(9):1359-1367. Jorgenson E, Thai KK, Hoffmann TJ, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Mertens J, Weisner C, Choquet H. PMID: 28485404.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    26. Validation of Electronic Health Records for the Assessment of Statin Dosing In Research. Journal of Clinical Lipidology. 2017 May 1; 11(3):836-837. Akinyemi Oni-Orisan, Thomas Hoffmann, Marisa Medina, Eric Jorgenson, Catherine Schaefer, Ronald Krauss, Carlos Iribarren, Neil Risch. .
      View in: Publisher Site   Mentions:
    27. Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. Nat Commun. 2017 01 31; 8:14248. Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR, Aaronson D, Presti J, Nordström T, Wang Z, Berndt SI, Chanock SJ, Mosley JD, Klein RJ, Middha M, Lilja H, Melander O, Kvale MN, Kwok PY, Schaefer C, Risch N, Van Den Eeden SK, Witte JS. PMID: 28139693.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. Nat Genet. 2017 01; 49(1):54-64. Hoffmann TJ, Ehret GB, Nandakumar P, Ranatunga D, Schaefer C, Kwok PY, Iribarren C, Chakravarti A, Risch N. PMID: 27841878.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    29. A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. PLoS Genet. 2016 Oct; 12(10):e1006371. Hoffmann TJ, Keats BJ, Yoshikawa N, Schaefer C, Risch N, Lustig LR. PMID: 27764096.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    30. Oxytocin and vasopressin hormone genes in children's externalizing problems: A cognitive endophenotype approach. Horm Behav. 2016 06; 82:78-86. Wade M, Hoffmann TJ, Knafo-Noam A, O'Connor TG, Jenkins JM. PMID: 27155104.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Mutational Landscape of Aggressive Prostate Tumors in African American Men. Cancer Res. 2016 04 01; 76(7):1860-8. Lindquist KJ, Paris PL, Hoffmann TJ, Cardin NJ, Kazma R, Mefford JA, Simko JP, Ngo V, Chen Y, Levin AM, Chitale D, Helfand BT, Catalona WJ, Rybicki BA, Witte JS. PMID: 26921337.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    32. Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation. Am Heart J. 2016 05; 175:9-17. Roberts JD, Dewland TA, Glidden DV, Hoffmann TJ, Arking DE, Chen LY, Psaty BM, Olgin JE, Alonso A, Heckbert SR, Marcus GM. PMID: 27179719.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    33. Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2016 05; 136(5):930-937. Asgari MM, Wang W, Ioannidis NM, Itnyre J, Hoffmann T, Jorgenson E, Whittemore AS. PMID: 26829030.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    34. Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration. Eur J Hum Genet. 2016 07; 24(7):1049-55. Jorgenson E, Melles RB, Hoffmann TJ, Jia X, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Shen L. PMID: 26733291.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Genome-Wide Estimates of Heritability for Social Demographic Outcomes. Biodemography Soc Biol. 2016; 62(1):1-18. Domingue BW, Wedow R, Conley D, McQueen M, Hoffmann TJ, Boardman JD. PMID: 27050030.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Strategies for Imputing and Analyzing Rare Variants in Association Studies. Trends Genet. 2015 Oct; 31(10):556-563. Hoffmann TJ, Witte JS. PMID: 26450338.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    37. Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4290-9. Shen L, Hoffmann TJ, Melles RB, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Jorgenson E. PMID: 26176866.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    38. Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug; 200(4):1061-72. Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP, Rowell S, Sadler M, Sakoda LC, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Risch N, Schaefer C, Blackburn EH. PMID: 26092717.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    39. Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug; 200(4):1285-95. Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, Sabatti C, Croen LA, Dispensa BP, Henderson M, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Olberg D, Quesenberry CP, Rowell S, Sadler M, Sakoda LC, Sciortino S, Shen L, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Schaefer C, Risch N. PMID: 26092716.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    40. Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug; 200(4):1051-60. Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, Croen LA, Dispensa BP, Eshragh J, Finn A, Gollub J, Iribarren C, Jorgenson E, Kushi LH, Lao R, Lu Y, Ludwig D, Mathauda GK, McGuire WB, Mei G, Miles S, Mittman M, Patil M, Quesenberry CP, Ranatunga D, Rowell S, Sadler M, Sakoda LC, Shapero M, Shen L, Shenoy T, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Wan E, Webster T, Whitmer RA, Wong S, Zau C, Zhan Y, Schaefer C, Kwok PY, Risch N. PMID: 26092718.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    41. A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Cancer Discov. 2015 Aug; 5(8):878-91. Hoffmann TJ, Van Den Eeden SK, Sakoda LC, Jorgenson E, Habel LA, Graff RE, Passarelli MN, Cario CL, Emami NC, Chao CR, Ghai NR, Shan J, Ranatunga DK, Quesenberry CP, Aaronson D, Presti J, Wang Z, Berndt SI, Chanock SJ, McDonnell SK, French AJ, Schaid DJ, Thibodeau SN, Li Q, Freedman ML, Penney KL, Mucci LA, Haiman CA, Henderson BE, Seminara D, Kvale MN, Kwok PY, Schaefer C, Risch N, Witte JS. PMID: 26034056.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    42. Detecting gene-environment interactions in human birth defects: Study designs and statistical methods. Birth Defects Res A Clin Mol Teratol. 2015 Aug; 103(8):692-702. Tai CG, Graff RE, Liu J, Passarelli MN, Mefford JA, Shaw GM, Hoffmann TJ, Witte JS. PMID: 26010994.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Gene-environment interaction between the oxytocin receptor (OXTR) gene and parenting behaviour on children's theory of mind. Soc Cogn Affect Neurosci. 2015 Dec; 10(12):1749-57. Wade M, Hoffmann TJ, Jenkins JM. PMID: 25977357.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther. 2015 May; 97(5):518-25. Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. PMID: 25676789.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    45. Replication and heritability of prostate cancer risk variants: impact of population-specific factors. Cancer Epidemiol Biomarkers Prev. 2015 Jun; 24(6):938-43. Virlogeux V, Graff RE, Hoffmann TJ, Witte JS. PMID: 25809866.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort. PLoS Genet. 2015 Jan; 11(1):e1004930. Hoffmann TJ, Sakoda LC, Shen L, Jorgenson E, Habel LA, Liu J, Kvale MN, Asgari MM, Banda Y, Corley D, Kushi LH, Quesenberry CP, Schaefer C, Van Den Eeden SK, Risch N, Witte JS. PMID: 25629170.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    47. Familial recurrence of autism spectrum disorder: evaluating genetic and environmental contributions. Am J Psychiatry. 2014 Nov 01; 171(11):1206-13. Risch N, Hoffmann TJ, Anderson M, Croen LA, Grether JK, Windham GC. PMID: 24969362.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansPHPublic Health
    48. Genome-wide discovery of drug-dependent human liver regulatory elements. PLoS Genet. 2014 Oct; 10(10):e1004648. Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. PMID: 25275310.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    49. Evidence of reproductive stoppage in families with autism spectrum disorder: a large, population-based cohort study. JAMA Psychiatry. 2014 Aug; 71(8):943-51. Hoffmann TJ, Windham GC, Anderson M, Croen LA, Grether JK, Risch N. PMID: 24942798.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    50. Association between the oxytocin receptor (OXTR) gene and children's social cognition at 18 months. Genes Brain Behav. 2014 Sep; 13(7):603-10. Wade M, Hoffmann TJ, Wigg K, Jenkins JM. PMID: 24916666.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    51. Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative. Hum Mol Genet. 2014 Dec 15; 23(24):6634-43. Hoffmann TJ, Tang H, Thornton TA, Caan B, Haan M, Millen AE, Thomas F, Risch N. PMID: 25027321.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    52. Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers' executive functioning. Brain Cogn. 2014 Oct; 90:116-23. Wade M, Hoffmann TJ, Jenkins JM. PMID: 25016245.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    53. Copy number variation in bronchopulmonary dysplasia. Am J Med Genet A. 2014 Oct; 164A(10):2672-5. Hoffmann TJ, Shaw GM, Stevenson DK, Wang H, Quaintance CC, Oehlert J, Jelliffe-Pawlowski LL, Gould JB, Witte JS, O'Brodovich HM. PMID: 24975634.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    54. Maternal smoking, xenobiotic metabolizing enzyme gene variants, and gastroschisis risk. Am J Med Genet A. 2014 Jun; 164A(6):1454-63. Jenkins MM, Reefhuis J, Gallagher ML, Mulle JG, Hoffmann TJ, Koontz DA, Sturchio C, Rasmussen SA, Witte JS, Richter P, Honein MA. PMID: 24668907.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    55. Functional characterization of SIM1-associated enhancers. Hum Mol Genet. 2014 Apr 01; 23(7):1700-8. Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N. PMID: 24203700.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    56. PS3-15: Genome-Wide Association Study of Anxiety Disorders: Early Results from Kaiser Permanente’s Research Program on Genes, Environment, and Health (RPGEH). Clinical Medicine & Research. 2013 Sep 1; 11(3):149-149. Ling Shen, Thomas Hoffmann, Mark Kvale, Lori Sakoda, Yambazi Banda, Pui-Yan Kwok, Neil Risch, Eric Jorgenson, Cathy Schaefer. .
      View in: Publisher Site   Mentions:
    57. B4-4: Genome-Wide Association Study of Macular Degeneration: Early Results from the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH). Clinical Medicine & Research. 2013 Sep 1; 11(3):146-147. Eric Jorgenson, Stan Sciortino, Ling Shen, Dilrini Ranatunga, Thomas Hoffmann, Mark Kvale, Yambazi Banda, Pui-Yan Kwok, Lawrence Walter, Neil Risch, Cathy Schaefer. .
      View in: Publisher Site   Mentions:
    58. African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative. Am Heart J. 2013 Sep; 166(3):566-72. Perez MV, Hoffmann TJ, Tang H, Thornton T, Stefanick ML, Larson JC, Kooperberg C, Reiner AP, Caan B, Iribarren C, Risch N. PMID: 24016508.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    59. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. Pediatrics. 2013 Aug; 132(2):290-7. Wang H, St Julien KR, Stevenson DK, Hoffmann TJ, Witte JS, Lazzeroni LC, Krasnow MA, Quaintance CC, Oehlert JW, Jelliffe-Pawlowski LL, Gould JB, Shaw GM, O'Brodovich HM. PMID: 23897914.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    60. Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. Am J Hum Genet. 2013 Jun 06; 92(6):904-16. Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, Reiner AP, Tang H. PMID: 23726366.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    61. Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative. Breast Cancer Res Treat. 2013 Jun; 139(2):461-8. Kaklamani VG, Hoffmann TJ, Thornton TA, Hayes G, Chlebowski R, Van Horn L, Mantzoros C. PMID: 23624817.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    62. The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies. Genet Epidemiol. 2013 May; 37(4):383-92. Lindquist KJ, Jorgenson E, Hoffmann TJ, Witte JS. PMID: 23529720.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    63. Association of DXA-derived bone mineral density and fat mass with African ancestry. J Clin Endocrinol Metab. 2013 Apr; 98(4):E713-7. Ochs-Balcom HM, Preus L, Wactawski-Wende J, Nie J, Johnson NA, Zakharia F, Tang H, Carlson C, Carty C, Chen Z, Hoffman T, Hutter CM, Jackson RD, Kaplan RC, Li L, Liu S, Neuhouser ML, Peters U, Robbins J, Seldin MF, Thornton TA, Thompson CL, Kooperberg C, Sucheston LE. PMID: 23436924.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    64. Estimating kinship in admixed populations. Am J Hum Genet. 2012 Jul 13; 91(1):122-38. Thornton T, Tang H, Hoffmann TJ, Ochs-Balcom HM, Caan BJ, Risch N. PMID: 22748210.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    65. A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis. PLoS One. 2011; 6(11):e28408. Marini NJ, Hoffmann TJ, Lammer EJ, Hardin J, Lazaruk K, Stein JB, Gilbert DA, Wright C, Lipzen A, Pennacchio LA, Carmichael SL, Witte JS, Shaw GM, Rine J. PMID: 22140583.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    66. Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates. BMC Proc. 2011 Nov 29; 5 Suppl 9:S29. Kazma R, Hoffmann TJ, Witte JS. PMID: 22373382.
      View in: PubMed   Mentions:
    67. Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm. Genomics. 2011 Dec; 98(6):422-30. Hoffmann TJ, Zhan Y, Kvale MN, Hesselson SE, Gollub J, Iribarren C, Lu Y, Mei G, Purdy MM, Quesenberry C, Rowell S, Shapero MH, Smethurst D, Somkin CP, Van den Eeden SK, Walter L, Webster T, Whitmer RA, Finn A, Schaefer C, Kwok PY, Risch N. PMID: 21903159.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    68. Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics. 2011 Aug; 98(2):79-89. Hoffmann TJ, Kvale MN, Hesselson SE, Zhan Y, Aquino C, Cao Y, Cawley S, Chung E, Connell S, Eshragh J, Ewing M, Gollub J, Henderson M, Hubbell E, Iribarren C, Kaufman J, Lao RZ, Lu Y, Ludwig D, Mathauda GK, McGuire W, Mei G, Miles S, Purdy MM, Quesenberry C, Ranatunga D, Rowell S, Sadler M, Shapero MH, Shen L, Shenoy TR, Smethurst D, Van den Eeden SK, Walter L, Wan E, Wearley R, Webster T, Wen CC, Weng L, Whitmer RA, Williams A, Wong SC, Zau C, Finn A, Schaefer C, Kwok PY, Risch N. PMID: 21565264.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    69. Parallel biocomputing. Source Code Biol Med. 2011 Mar 18; 6:4. Kompass KS, Hoffmann TJ, Witte JS. PMID: 21418580.
      View in: PubMed   Mentions:
    70. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70. Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM. PMID: 21401569.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    71. J Stat Softw. Parsing in command line arguments and parallel cluster/multicore batching in R with batch. 2011; 39. Hoffmann TJ..
    72. Passing in Command Line Arguments and Parallel Cluster/Multicore Batching in R with batch. J Stat Softw. 2011 Mar; 39. Hoffmann TJ. PMID: 25431538.
      View in: PubMed   Mentions:
    73. Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer. OMICS. 2011 Jun; 15(6):393-8. Witte JS, Hoffmann TJ. PMID: 21348634.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    74. Comprehensive approach to analyzing rare genetic variants. PLoS One. 2010 Nov 03; 5(11):e13584. Hoffmann TJ, Marini NJ, Witte JS. PMID: 21072163.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    75. Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study. Genet Epidemiol. 2010 Nov; 34(7):674-9. Sebro R, Hoffman TJ, Lange C, Rogus JJ, Risch NJ. PMID: 20842694.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    76. Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. Respir Res. 2010 Mar 16; 11:30. Cho MH, Washko GR, Hoffmann TJ, Criner GJ, Hoffman EA, Martinez FJ, Laird N, Reilly JJ, Silverman EK. PMID: 20233420.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    77. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103. Hoffmann TJ, Lange C, Vansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM. PMID: 19996607.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    78. Gene-environment interaction tests for dichotomous traits in trios and sibships. Genet Epidemiol. 2009 Dec; 33(8):691-9. Hoffmann TJ, Lange C, Vansteelandt S, Laird NM. PMID: 19365860.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    79. fgui: A Method for Automatically Creating Graphical User Interfaces for Command-Line R Packages. J Stat Softw. 2009 Apr 01; 30(2). Hoffmann TJ, Laird NM. PMID: 21625291.
      View in: PubMed   Mentions:
    80. P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R. Bioinformatics. 2006 Dec 15; 22(24):3103-5. Hoffmann T, Lange C. PMID: 17021156.
      View in: PubMed   Mentions: 9     Fields:    
    Thomas's Networks
    Concepts (299)
    Derived automatically from this person's publications.
    _
    Co-Authors (53)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _