Lenore Pereira, PhD

InstitutionUniversity of California San Francisco
DepartmentCell and Tissue Biology
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    Collapse Research 
    Collapse Research Activities and Funding
    Fetal Zika virus infection: role of the human placenta
    NIH/NIAID R21AI129508Nov 18, 2016 - Oct 31, 2018
    Role: Principal Investigator
    HCMV infection of human placental trophoblast and hematopoietic progenitors
    NIH/NIAID R56AI101130Sep 15, 2012 - Aug 31, 2014
    Role: Principal Investigator
    HCMV infection and immune modulation in a human placentation model in SCID mice
    NIH/NIAID R21AI090200Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator
    Compensatory placental development after treatment for congenital CMV infection
    NIH/NIAID R56AI073752Sep 15, 2008 - Aug 30, 2009
    Role: Principal Investigator
    Congenital CMV Conference: Education, Prevention and Treatment
    NIH/NICHD R13HD059278Sep 1, 2008 - Aug 31, 2009
    Role: Principal Investigator
    Human Placental CMV Infection: Global Gene Expression
    NIH/NIAID R21AI053782Sep 30, 2002 - Aug 31, 2005
    Role: Principal Investigator
    NIH/NEI R01EY013683May 1, 2001 - Apr 30, 2005
    Role: Principal Investigator
    Fetal HCMV Infection: Role of the Human Placenta
    NIH/NIAID R01AI046657Feb 1, 2000 - Feb 28, 2018
    Role: Principal Investigator
    Fetal CMV Infection: Role of the Human Placenta
    NIH/NIAID R56AI046657Feb 1, 2000 - Feb 14, 2006
    Role: Principal Investigator
    NIH/NEI R01EY011223Sep 30, 1995 - Sep 29, 2000
    Role: Principal Investigator
    NIH/NEI R01EY010138Mar 1, 1993 - Aug 31, 1999
    Role: Principal Investigator
    NIH/NICHD S15HD025081Sep 1, 1988 - Aug 31, 1989
    Role: Principal Investigator
    NIH/NIAID R01AI030873May 1, 1987 - Jul 31, 1996
    Role: Principal Investigator
    NIH/NIDCR R01DE008275May 1, 1987 - Aug 31, 1990
    Role: Principal Investigator
    NIH/NIAID R01AI023592Sep 1, 1985 - Aug 31, 1991
    Role: Principal Investigator

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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pereira L. Congenital Viral Infection: Traversing the Uterine-Placental Interface. Annu Rev Virol. 2018 Jul 26. PMID: 30048217.
      View in: PubMed
    2. Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Harris E, Pereira L. Zika Virus Replicates in Proliferating Cells in Explants From First-Trimester Human Placentas, Potential Sites for Dissemination of Infection. J Infect Dis. 2018 Mar 28; 217(8):1202-1213. PMID: 29106643.
      View in: PubMed
    3. Petitt M, Tabata T, Puerta-Guardo H, Harris E, Pereira L. Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo. Curr Opin Virol. 2017 12; 27:48-56. PMID: 29172071.
      View in: PubMed
    4. Pereira L, Tabata T, Petitt M, Fang-Hoover J. Congenital cytomegalovirus infection undermines early development and functions of the human placenta. Placenta. 2017 Nov; 59 Suppl 1:S8-S16. PMID: 28477968.
      View in: PubMed
    5. Tabata T, Petitt M, Fang-Hoover J, Zydek M, Pereira L. Persistent Cytomegalovirus Infection in Amniotic Membranes of the Human Placenta. Am J Pathol. 2016 Nov; 186(11):2970-2986. PMID: 27638253.
      View in: PubMed
    6. Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J, Harris E, Pereira L. Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission. Cell Host Microbe. 2016 Aug 10; 20(2):155-66. PMID: 27443522.
      View in: PubMed
    7. Tabata T, Petitt M, Zydek M, Fang-Hoover J, Larocque N, Tsuge M, Gormley M, Kauvar LM, Pereira L. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta. J Virol. 2015 May; 89(9):5134-47. PMID: 25741001; PMCID: PMC4403461.
    8. Kauvar LM, Liu K, Park M, DeChene N, Stephenson R, Tenorio E, Ellsworth SL, Tabata T, Petitt M, Tsuge M, Fang-Hoover J, Adler SP, Cui X, McVoy MA, Pereira L. A high-affinity native human antibody neutralizes human cytomegalovirus infection of diverse cell types. Antimicrob Agents Chemother. 2015 Mar; 59(3):1558-68. PMID: 25534746; PMCID: PMC4325823.
    9. Zydek M, Petitt M, Fang-Hoover J, Adler B, Kauvar LM, Pereira L, Tabata T. HCMV infection of human trophoblast progenitor cells of the placenta is neutralized by a human monoclonal antibody to glycoprotein B and not by antibodies to the pentamer complex. Viruses. 2014 Mar 19; 6(3):1346-64. PMID: 24651029; PMCID: PMC3970154.
    10. McCutcheon KM, Gray J, Chen NY, Liu K, Park M, Ellsworth S, Tripp RA, Tompkins SM, Johnson SK, Samet S, Pereira L, Kauvar LM. Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets. MAbs. 2014 Mar-Apr; 6(2):460-73. PMID: 24492306; PMCID: PMC3984334.
    11. Pereira L, Petitt M, Fong A, Tsuge M, Tabata T, Fang-Hoover J, Maidji E, Zydek M, Zhou Y, Inoue N, Loghavi S, Pepkowitz S, Kauvar LM, Ogunyemi D. Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection. J Infect Dis. 2014 May 15; 209(10):1573-84. PMID: 24403553; PMCID: PMC3997585.
    12. Kirchmeier M, Fluckiger AC, Soare C, Bozic J, Ontsouka B, Ahmed T, Diress A, Pereira L, Schödel F, Plotkin S, Dalba C, Klatzmann D, Anderson DE. Enveloped virus-like particle expression of human cytomegalovirus glycoprotein B antigen induces antibodies with potent and broad neutralizing activity. Clin Vaccine Immunol. 2014 Feb; 21(2):174-80. PMID: 24334684; PMCID: PMC3910943.
    13. Pereira L, Petitt M, Tabata T. Cytomegalovirus infection and antibody protection of the developing placenta. Clin Infect Dis. 2013 Dec; 57 Suppl 4:S174-7. PMID: 24257421; PMCID: PMC3897280.
    14. Tabata T, Petitt M, Fang-Hoover J, Rivera J, Nozawa N, Shiboski S, Inoue N, Pereira L. Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model. Am J Pathol. 2012 Nov; 181(5):1540-59. PMID: 22959908; PMCID: PMC3483806.
    15. Pereira L. Have we overlooked congenital cytomegalovirus infection as a cause of stillbirth? J Infect Dis. 2011 Jun 01; 203(11):1510-2. PMID: 21592978.
      View in: PubMed
    16. Maidji E, Nigro G, Tabata T, McDonagh S, Nozawa N, Shiboski S, Muci S, Anceschi MM, Aziz N, Adler SP, Pereira L. Antibody treatment promotes compensation for human cytomegalovirus-induced pathogenesis and a hypoxia-like condition in placentas with congenital infection. Am J Pathol. 2010 Sep; 177(3):1298-310. PMID: 20651234; PMCID: PMC2928963.
    17. Adler SP, Nigro G, Pereira L. Screening for cytomegalovirus during pregnancy. Am J Obstet Gynecol. 2010 Jul; 203(1):e15; author reply e15-6. PMID: 20227052.
      View in: PubMed
    18. Nozawa N, Fang-Hoover J, Tabata T, Maidji E, Pereira L. Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream. J Clin Virol. 2009 Dec; 46 Suppl 4:S58-63. PMID: 19854676; PMCID: PMC2794836.
    19. Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L. Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Am J Pathol. 2008 Apr; 172(4):1127-40. PMID: 18349127; PMCID: PMC2276431.
    20. Pereira L, Maidji E. Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on trophoblasts converge. Curr Top Microbiol Immunol. 2008; 325:383-95. PMID: 18637517.
      View in: PubMed
    21. Maidji E, Genbacev O, Chang HT, Pereira L. Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta. J Virol. 2007 May; 81(9):4701-12. PMID: 17314173; PMCID: PMC1900158.
    22. Adler SP, Nigro G, Pereira L. Recent advances in the prevention and treatment of congenital cytomegalovirus infections. Semin Perinatol. 2007 Feb; 31(1):10-8. PMID: 17317422.
      View in: PubMed
    23. Winn VD, Haimov-Kochman R, Paquet AC, Yang YJ, Madhusudhan MS, Gormley M, Feng KT, Bernlohr DA, McDonagh S, Pereira L, Sali A, Fisher SJ. Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term. Endocrinology. 2007 Mar; 148(3):1059-79. PMID: 17170095.
      View in: PubMed
    24. Maidji E, McDonagh S, Genbacev O, Tabata T, Pereira L. Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis. Am J Pathol. 2006 Apr; 168(4):1210-26. PMID: 16565496; PMCID: PMC1606573.
    25. McDonagh S, Maidji E, Chang HT, Pereira L. Patterns of human cytomegalovirus infection in term placentas: a preliminary analysis. J Clin Virol. 2006 Feb; 35(2):210-5. PMID: 16386950.
      View in: PubMed
    26. Pereira L, Maidji E, McDonagh S, Tabata T. Insights into viral transmission at the uterine-placental interface. Trends Microbiol. 2005 Apr; 13(4):164-74. PMID: 15817386.
      View in: PubMed
    27. McDonagh S, Maidji E, Ma W, Chang HT, Fisher S, Pereira L. Viral and bacterial pathogens at the maternal-fetal interface. J Infect Dis. 2004 Aug 15; 190(4):826-34. PMID: 15272412.
      View in: PubMed
    28. Yamamoto-Tabata T, McDonagh S, Chang HT, Fisher S, Pereira L. Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro. J Virol. 2004 Mar; 78(6):2831-40. PMID: 14990702; PMCID: PMC353759.
    29. Pereira L, Maidji E, McDonagh S, Genbacev O, Fisher S. Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity. J Virol. 2003 Dec; 77(24):13301-14. PMID: 14645586; PMCID: PMC296088.
    30. Maidji E, Percivalle E, Gerna G, Fisher S, Pereira L. Transmission of human cytomegalovirus from infected uterine microvascular endothelial cells to differentiating/invasive placental cytotrophoblasts. Virology. 2002 Dec 05; 304(1):53-69. PMID: 12490403.
      View in: PubMed