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Dean Sheppard, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-514-4269
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    SUNY, Stony BrookM.D.1975School of Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    ASCI1992Elected Member, American Society for Clinical Investigation
    AAP1995Elected Member, Association of American Physicians
    California Lung Association1995Clean Air Award
    American Thoracic Society1998Scientific Achievement Award
    NIH2004  - 2014NIH Merit Award
    American Thoracic Society2010Amberson Lecturer
    Nature Biotechnology2013Top 20 Translational Scientists
    UCSF2016UCSF Fraculty Research Lecture in Translational Science
    AAAS2018Elected Member, American Academy of Arts and Sciences

    Collapse Overview 
    Collapse Overview
    Dean Sheppard is a Professor of Medicine, Chief of the Division of Pulmonary, Critical Care, Allergy and Sleep and director of the Lung Biology Center. His research focuses on the molecular mechanisms underlying pulmonary (and other organ) fibrosis, asthma and acute lung injury. One aim of the research is to identify new therapeutic targets to ultimately improve the treatment of each of these common diseases. The work begins with basic investigation of how cells use members of the integrin family to detect, modify and respond to spatially restricted extracellular clues and how these responses contribute to the development of common lung diseases. Utilizing mice with global or conditional knockouts of the epithelial-restricted integrin, avß6, and the widely expressed integrins, a5ß1, a9ß1, avß5 and avß8, the lab has identified important roles for these integrins in models of each common lung disease and key steps upstream and downstream of the integrins that provide potential therapeutic targets. His lab identified the unique roles that 3 integrins, avß1, avß6 and avß8 play in activation of the growth factor, latent transforming growth factor beta (TGFß) and has identified critical roles for this process in acute lung injury, pulmonary fibrosis, post-natal brain development and immunosuppression in the setting of cancer. The lab has partnered with academic colleagues, biotech and pharmaceutical companies to develop novel antibody and small molecule inhibitors of these integrins that are in various stages of pre-clinical and clinical development. Current work is also using single cell RNA sequencing to understand the heterogeneity of cells that contribute to tissue fibrosis in the lung, skin, kidney, liver and central nervous system and is exploring the potential of engineering T cells for local delivery of novel therapeutics to fibrotic organs.

    Collapse Research 
    Collapse Research Activities and Funding
    Fibroblast heterogeneity in pulmonary fibrosis
    NIH/NHLBI R01HL142568Apr 1, 2020 - Mar 31, 2024
    Role: Principal Investigator
    Interventional Targeting of the IRE1alpha-TGFbeta signaling loop in pulmonary fibrosis
    NIH/NHLBI R01HL145037Feb 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    20th Biennial International Conference on Lung and Airway Fibrosis (ICLAF)
    NIH/NHLBI R13HL140841Aug 1, 2018 - Jul 31, 2019
    Role: Co-Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH/NHLBI UH2HL123423Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH/NHLBI UH3HL123423Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH/NHLBI P01HL108794Aug 9, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Integrin-mediated Regulation of Airway Smooth Muscle
    NIH/NHLBI R01HL102292Dec 3, 2010 - Nov 30, 2015
    Role: Principal Investigator
    Understanding Asthma Endotypes
    NIH/NIAID U19AI077439Apr 1, 2008 - Mar 31, 2023
    Role: Co-Principal Investigator
    Regulation of Pulmonary Vascular Permeability by Integrin AlphaVBeta5
    NIH/NHLBI R01HL083950Apr 1, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Conference on Fibronectin, Integrins &Related Molecules
    NIH/NCI R13CA097981Jan 17, 2003 - Dec 31, 2007
    Role: Principal Investigator
    The NHLBI-Bay Area Functional Genomics Consortium
    NIH/NHLBI U01HL066600Sep 30, 2000 - Jul 31, 2008
    Role: Principal Investigator
    Integrin-Mediated Development of the Thoracic Duct
    NIH/NHLBI R01HL064353Feb 1, 2000 - Nov 30, 2009
    Role: Principal Investigator
    Interactions of Lymphocytes, Cytokines and Airway Cells
    NIH/NHLBI P50HL056385Sep 1, 1997 - Aug 31, 2006
    Role: Principal Investigator
    MECHANISMS OF PERSISTENT AIRWAY INFLAMMATION IN ASTHMA
    NIH/NHLBI P01HL056385Sep 30, 1996 - Aug 31, 2001
    Role: Principal Investigator
    In Vivo Function of Pulmonary Integrins
    NIH/NHLBI R37HL053949Apr 1, 1995 - Mar 31, 2014
    Role: Principal Investigator
    In Vivo Function of Pulmonary Integrins
    NIH/NHLBI R01HL053949Apr 1, 1995 - Mar 31, 2009
    Role: Principal Investigator
    SCIENTIFIC REVIEW AND EVALUATION GRANT
    NIH/NHLBI U09HL053927Jun 1, 1994 - Sep 1, 2003
    Role: Co-Principal Investigator
    FUNCTION OF A NOVEL AIRWAY EPITHELIAL ADHESION RECEPTOR
    NIH/NHLBI R01HL047412Jan 23, 1992 - May 31, 2000
    Role: Principal Investigator
    Novel Leukocyte Integrins
    NIH/NIAID R01AI024674Sep 1, 1988 - Sep 29, 1995
    Role: Principal Investigator
    AIRWAY EPITHELIAL RECEPTORS FOR EXTRACELLULAR MATRIX
    NIH/NHLBI R01HL033259Sep 20, 1985 - Sep 19, 1988
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Multidisciplinary Training Program in Lung Disease
    NIH/NHLBI T32HL007185Jul 1, 1976 - Jun 30, 2022
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier. J Clin Invest. 2020 Jun 22. Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD. PMID: 32369453.
      View in: PubMed   Mentions:    Fields:    
    2. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat Commun. 2020 Apr 21; 11(1):1920. Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D. PMID: 32317643.
      View in: PubMed   Mentions:    Fields:    
    3. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Sci Adv. 2020 02; 6(7):eaay7667. Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK. PMID: 32095531.
      View in: PubMed   Mentions: 1     Fields:    
    4. A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion. J Biol Chem. 2019 11 29; 294(48):18232-18243. Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB. PMID: 31640988.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Impaired aVß8 and TGFß signaling lead to microglial dysmaturation and neuromotor dysfunction. J Exp Med. 2019 04 01; 216(4):900-915. Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D. PMID: 30846482.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. ß6 -integrin serves as a novel serum tumor marker for colorectal carcinoma. Int J Cancer. 2019 08 01; 145(3):678-685. Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M. PMID: 30653264.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. IL-17A Recruits Rab35 to IL-17R to Mediate PKCa-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility. J Immunol. 2019 03 01; 202(5):1540-1548. Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X. PMID: 30683702.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019; 14(1):e0209824. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. PMID: 30625178.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Loss of Integrin avß8 in Murine Hepatocytes Accelerates Liver Regeneration. Am J Pathol. 2019 02; 189(2):258-271. Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC. PMID: 30448409.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 11 02; 3(21). Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M. PMID: 30385725.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    11. Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation. Am J Physiol Lung Cell Mol Physiol. 2018 09 01; 315(3):L360-L370. Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K. PMID: 29792348.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. TGF-ß1 Signaling and Tissue Fibrosis. Cold Spring Harb Perspect Biol. 2018 04 02; 10(4). Kim KK, Sheppard D, Chapman HA. PMID: 28432134.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    13. Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin aVß8. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):E10161-E10168. Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S. PMID: 29109269.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L878-L888. Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D. PMID: 28818870.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 05; 56(5):667-679. Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES. PMID: 28459387.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    16. Pharmacologic Blockade of avß1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. J Am Soc Nephrol. 2017 Jul; 28(7):1998-2005. Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. PMID: 28220032.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    17. Targeting integrin a5ß1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 01 03; 127(1):365-374. Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. PMID: 27918306.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    18. Transforming growth factor-ß plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L22-L31. Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D. PMID: 27864286.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective avß1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Oct 13; 7(10):902-907. Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H. PMID: 27774126.
      View in: PubMed   Mentions:
    20. An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens. PLoS Pathog. 2016 08; 12(8):e1005804. Meliopoulos VA, Van de Velde LA, Van de Velde NC, Karlsson EA, Neale G, Vogel P, Guy C, Sharma S, Duan S, Surman SL, Jones BG, Johnson MD, Bosio C, Jolly L, Jenkins RG, Hurwitz JL, Rosch JW, Sheppard D, Thomas PG, Murray PJ, Schultz-Cherry S. PMID: 27505057.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome. J Immunol. 2016 07 01; 197(1):97-107. McAleer JP, Nguyen NL, Chen K, Kumar P, Ricks DM, Binnie M, Armentrout RA, Pociask DA, Hein A, Yu A, Vikram A, Bibby K, Umesaki Y, Rivera A, Sheppard D, Ouyang W, Hooper LV, Kolls JK. PMID: 27217583.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    22. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. PMID: 27174992.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    23. a-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFß activation or collagen production across multiple models of organ fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L824-36. Sun KH, Chang Y, Reed NI, Sheppard D. PMID: 26944089.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    24. Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-ß. Nat Immunol. 2016 Apr; 17(4):414-21. Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. PMID: 26901152.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    25. Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma. Curr Rheumatol Rep. 2016 Jan; 18(1):4. Tsujino K, Sheppard D. PMID: 26711695.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Integrin avß6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis. Hepatology. 2016 Jan; 63(1):217-32. Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y. PMID: 26448099.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    27. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. PMID: 26321127.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015 Jul 01; 195(1):87-95. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D. PMID: 26002979.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    29. The avß1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79. Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. PMID: 25995225.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    30. Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-ß activation by epithelial cells and fibroblasts. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S21-3. Sheppard D. PMID: 25830829.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    31. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. PMID: 25526531.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aVß8-TGFß signaling in the brain. Development. 2014 Dec; 141(23):4489-99. Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. PMID: 25406396.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    33. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. PMID: 25271629.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    34. The cell biology of asthma. J Cell Biol. 2014 Jun 09; 205(5):621-31. Erle DJ, Sheppard D. PMID: 24914235.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    35. Integrin a9 on lymphatic endothelial cells regulates lymphocyte egress. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3080-5. Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. PMID: 24516133.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Inhibition of the avß6 integrin leads to limited alteration of TGF-a-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15; 306(8):L726-35. Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD. PMID: 24508732.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    37. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. PMID: 24160862.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    38. TGF-ß activation and function in immunity. Annu Rev Immunol. 2014; 32:51-82. Travis MA, Sheppard D. PMID: 24313777.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    39. Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. PMID: 24216753.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    40. Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9914-9. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. PMID: 23716700.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    41. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May; 123(5):2037-48. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. PMID: 23543053.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    42. ROCKing pulmonary fibrosis. J Clin Invest. 2013 Mar; 123(3):1005-6. Sheppard D. PMID: 23434586.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    43. Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin avß5. Crit Care Med. 2013 Feb; 41(2):546-53. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. PMID: 23263571.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    44. Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med. 2013 Jan 09; 5(167):167sr1. Friedman SL, Sheppard D, Duffield JS, Violette S. PMID: 23303606.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansCells
    45. Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18042-7. Freimuth J, Clermont FF, Huang X, DeSapio A, Tokuyasu TA, Sheppard D, Akhurst RJ. PMID: 23064636.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    46. Integrin-mediated regulation of TGFß in fibrosis. Biochim Biophys Acta. 2013 Jul; 1832(7):891-6. Henderson NC, Sheppard D. PMID: 23046811.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    47. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. PMID: 22988107.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    48. Integrin a9ß1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest. 2012 Aug; 122(8):2916-27. Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. PMID: 22772469.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    49. Modulation of acute lung injury by integrins. Proc Am Thorac Soc. 2012 Jul; 9(3):126-9. Sheppard D. PMID: 22802286.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    50. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. PMID: 22585735.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    51. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 01; 303(1):L12-9. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. PMID: 22561460.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    52. IL-17A produced by aß T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med. 2012 Mar 04; 18(4):547-54. Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. PMID: 22388091.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    53. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol. 2012 Mar 15; 188(6):2622-9. Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH. PMID: 22327070.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    54. Epithelial cells utilize cortical actin/myosin to activate latent TGF-ß through integrin a(v)ß(6)-dependent physical force. Exp Cell Res. 2012 Apr 01; 318(6):716-22. Giacomini MM, Travis MA, Kudo M, Sheppard D. PMID: 22309779.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    55. The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb; 122(2):748-58. Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. PMID: 22232213.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    56. Absence of integrin avß3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):58-66. Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. PMID: 21980034.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    57. Cross talk among TGF-ß signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol. 2011 Nov 01; 3(11):a005017. Munger JS, Sheppard D. PMID: 21900405.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    58. Integrin avß5-mediated TGF-ß activation by airway smooth muscle cells in asthma. J Immunol. 2011 Dec 01; 187(11):6094-107. Tatler AL, John AE, Jolly L, Habgood A, Porte J, Brightling C, Knox AJ, Pang L, Sheppard D, Huang X, Jenkins G. PMID: 22025551.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    59. Blocking TGFß via Inhibition of the avß6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. Int J Rheumatol. 2011; 2011:208219. Katsumoto TR, Violette SM, Sheppard D. PMID: 22013449.
      View in: PubMed   Mentions:
    60. Recommendations for the classification of diseases as CFTR-related disorders. J Cyst Fibros. 2011 Jun; 10 Suppl 2:S86-102. Bombieri C, Claustres M, De Boeck K, Derichs N, Dodge J, Girodon E, Sermet I, Schwarz M, Tzetis M, Wilschanski M, Bareil C, Bilton D, Castellani C, Cuppens H, Cutting GR, Drevínek P, Farrell P, Elborn JS, Jarvi K, Kerem B, Kerem E, Knowles M, Macek M, Munck A, Radojkovic D, Seia M, Sheppard DN, Southern KW, Stuhrmann M, Tullis E, Zielenski J, Pignatti PF, Ferec C. PMID: 21658649.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    61. Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era. Proc Am Thorac Soc. 2011 May; 8(2):199-202. Sheppard D. PMID: 21543802.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    62. Short form of a9 promotes a9ß1 integrin-dependent cell adhesion by modulating the function of the full-length a9 subunit. Exp Cell Res. 2011 Jul 15; 317(12):1774-84. Kon S, Atakilit A, Sheppard D. PMID: 21515257.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    63. Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. J Biol Chem. 2011 Apr 01; 286(13):11170-8. Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y. PMID: 21321126.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    64. Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Mol Cell Biol. 2011 Feb; 31(4):766-82. Spassov DS, Wong CH, Sergina N, Ahuja D, Fried M, Sheppard D, Moasser MM. PMID: 21189288.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    65. Expression of avß8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. J Clin Invest. 2010 Dec; 120(12):4436-44. Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D. PMID: 21099117.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    66. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest. 2009 Dec; 119(12):3713-22. Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. PMID: 19884654.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    67. beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2010 Jul; 43(1):88-98. Hogmalm A, Sheppard D, Lappalainen U, Bry K. PMID: 19717813.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    68. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009 Aug; 17(2):175-86. Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T. PMID: 19686679.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    69. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem. 2009 Jul 17; 284(29):19650-8. Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. PMID: 19435888.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    70. Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Blood. 2009 Jul 02; 114(1):49-59. Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT, Sheppard D, Choong PF, Nilsson SK. PMID: 19417209.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    71. Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). Am J Pathol. 2009 Apr; 174(4):1264-79. Xu MY, Porte J, Knox AJ, Weinreb PH, Maher TM, Violette SM, McAnulty RJ, Sheppard D, Jenkins G. PMID: 19147812.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    72. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol. 2009 Jan; 129(1):217-28. Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L. PMID: 18633440.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    73. The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A. 2008 May 20; 105(20):7188-93. deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D. PMID: 18480266.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    74. Dust mites' dirty dealings with dendritic cells. Nat Med. 2008 May; 14(5):487-8. Sheppard D. PMID: 18463654.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    75. Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Am J Pathol. 2008 Apr; 172(4):1127-40. Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L. PMID: 18349127.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    76. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. PMID: 18276918.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    77. An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med. 2008 Mar 15; 177(6):638-45. Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES. PMID: 18096707.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    78. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. PMID: 17965775.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    79. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med. 2008 Jan 01; 177(1):56-65. Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, Simon KJ, Hahm K, Allaire NE, Rinaldi NJ, Goyal J, Feghali-Bostwick CA, Matteson EL, O'Hara C, Lafyatis R, Davis GS, Huang X, Sheppard D, Violette SM. PMID: 17916809.
      View in: PubMed   Mentions: 113     Fields:    Translation:Animals
    80. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 2007 Sep 20; 449(7160):361-5. Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. PMID: 17694047.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    81. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9. Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. PMID: 17641300.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    82. Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12005-10. Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC. PMID: 17620600.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    83. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. PMID: 17468134.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    84. Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem. 2007 May 18; 282(20):15187-96. Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D. PMID: 17363377.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    85. Roles of the innate immune system in mammary gland remodeling during involution. J Mammary Gland Biol Neoplasia. 2007 Mar; 12(1):37-45. Atabai K, Sheppard D, Werb Z. PMID: 17286210.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    86. Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol. 2007 Jan; 170(1):110-25. Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, McCrann DJ, Allaire NE, Horan GS, Fogo A, Kalluri R, Shield CF, Sheppard D, Gardner HA, Violette SM. PMID: 17200187.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    87. Identification and molecular characterization of multiple phenotypes in integrin knockout mice. Methods Enzymol. 2007; 426:291-305. Chen C, Sheppard D. PMID: 17697889.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    88. Pulmonary emphysema: when more is less. Physiology (Bethesda). 2006 Dec; 21:396-403. Morris DG, Sheppard D. PMID: 17119152.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    89. The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Immunity. 2006 Dec; 25(6):895-906. Chen C, Huang X, Atakilit A, Zhu QS, Corey SJ, Sheppard D. PMID: 17137800.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    90. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. PMID: 17079779.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    91. Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res. 2006 Oct; 21(10):1657-65. Rao H, Lu G, Kajiya H, Garcia-Palacios V, Kurihara N, Anderson J, Patrene K, Sheppard D, Blair HC, Windle JJ, Choi SJ, Roodman GD. PMID: 16995821.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    92. ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol. 2006 Sep; 26(18):6950-6. Chen C, Huang X, Sheppard D. PMID: 16943435.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    93. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13180-5. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. PMID: 16924102.
      View in: PubMed   Mentions: 430     Fields:    Translation:HumansAnimalsCells
    94. Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc. 2006 Jul; 3(5):413-7. Sheppard D. PMID: 16799084.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimals
    95. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006 Jun; 116(6):1606-14. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. PMID: 16710477.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    96. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):252-9. Neurohr C, Nishimura SL, Sheppard D. PMID: 16574941.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    97. Population stratification confounds genetic association studies among Latinos. Hum Genet. 2006 Jan; 118(5):652-64. Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard D, Shriver MD, Rodriguez-Cintron W, Risch N, Ziv E, Burchard EG. PMID: 16283388.
      View in: PubMed   Mentions: 108     Fields:    Translation:Humans
    98. Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell. 2005 Dec; 16(12):5528-37. Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. PMID: 16195353.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    99. Integrin-mediated activation of latent transforming growth factor beta. Cancer Metastasis Rev. 2005 Sep; 24(3):395-402. Sheppard D. PMID: 16258727.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    100. Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol. 2005 Jul; 29(1):76-86. Salari K, Choudhry S, Tang H, Naqvi M, Lind D, Avila PC, Coyle NE, Ung N, Nazario S, Casal J, Torres-Palacios A, Clark S, Phong A, Gomez I, Matallana H, Pérez-Stable EJ, Shriver MD, Kwok PY, Sheppard D, Rodriguez-Cintron W, Risch NJ, Burchard EG, Ziv E. PMID: 15918156.
      View in: PubMed   Mentions: 83     Fields:    Translation:Humans
    101. Characterization of integrin beta6 and thrombospondin-1 double-null mice. J Cell Mol Med. 2005 Apr-Jun; 9(2):421-37. Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J. PMID: 15963261.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    102. ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7. Biochem J. 2005 Apr 01; 387(Pt 1):101-8. Bridges LC, Sheppard D, Bowditch RD. PMID: 15504110.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    103. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem. 2005 May 13; 280(19):18579-89. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF. PMID: 15755725.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    104. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005 Feb; 115(2):339-47. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM. PMID: 15668738.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    105. Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. J Exp Med. 2004 Dec 20; 200(12):1539-45. Nandrot EF, Kim Y, Brodie SE, Huang X, Sheppard D, Finnemann SC. PMID: 15596525.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    106. The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. J Biol Chem. 2005 Feb 11; 280(6):4544-52. Vlahakis NE, Young BA, Atakilit A, Sheppard D. PMID: 15590642.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    107. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):563-70. Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, Lilly C, Matallana H, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Drazen JM, Rodriguez-Cintron W, Silverman EK, Burchard EG. PMID: 15557128.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    108. Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res. 2005 Jan; 20(1):58-66. Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL. PMID: 15619670.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    109. Fishing in the bloodstream: insights into the mechanisms of pulmonary hypertension? Am J Respir Crit Care Med. 2004 Oct 15; 170(8):827-8. Sheppard D. PMID: 15475403.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    110. Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol. 2004 Oct 11; 167(1):161-70. Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D. PMID: 15479742.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    111. Roles of alphav integrins in vascular biology and pulmonary pathology. Curr Opin Cell Biol. 2004 Oct; 16(5):552-7. Sheppard D. PMID: 15363806.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    112. Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. J Virol. 2004 Jul; 78(13):6967-73. Williams CH, Kajander T, Hyypiä T, Jackson T, Sheppard D, Stanway G. PMID: 15194773.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    113. Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins. Biochemistry. 2004 Feb 17; 43(6):1639-47. Bazan-Socha S, Kisiel DG, Young B, Theakston RD, Calvete JJ, Sheppard D, Marcinkiewicz C. PMID: 14769041.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    114. Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes. J Biol Chem. 2004 Apr 23; 279(17):17875-87. Weinreb PH, Simon KJ, Rayhorn P, Yang WJ, Leone DR, Dolinski BM, Pearse BR, Yokota Y, Kawakatsu H, Atakilit A, Sheppard D, Violette SM. PMID: 14960589.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    115. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004 Feb 01; 169(3):386-92. Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK. PMID: 14617512.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    116. Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Exp Cell Res. 2003 Oct 15; 290(1):68-81. Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM. PMID: 14516789.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    117. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol. 2003 Oct; 163(4):1261-73. Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. PMID: 14507636.
      View in: PubMed   Mentions: 78     Fields:    Translation:Animals
    118. Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. Am J Respir Cell Mol Biol. 2004 Apr; 30(4):540-7. Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM. PMID: 12972402.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    119. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1312-6. Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, Chapela R, Ford JG, Rodriguez-Cintron W, Silverman EK, Sheppard D, Kwok PY, González Burchard E. PMID: 12958057.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    120. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. PMID: 12930837.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    121. Functions of pulmonary epithelial integrins: from development to disease. Physiol Rev. 2003 Jul; 83(3):673-86. Sheppard D. PMID: 12843406.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    122. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003 Mar 20; 348(12):1170-5. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N. PMID: 12646676.
      View in: PubMed   Mentions: 219     Fields:    Translation:Humans
    123. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature. 2003 Mar 13; 422(6928):169-73. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. PMID: 12634787.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    124. Endothelial integrins and angiogenesis: not so simple anymore. J Clin Invest. 2002 Oct; 110(7):913-4. Sheppard D. PMID: 12370267.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    125. Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1. Am J Pathol. 2002 Sep; 161(3):771-9. Knight PA, Wright SH, Brown JK, Huang X, Sheppard D, Miller HR. PMID: 12213704.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    126. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2002 Jul 15; 166(2):236-46. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA. PMID: 12119236.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    127. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002 Aug; 8(8):885-9. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. PMID: 12091879.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansAnimalsCells
    128. Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6292-7. Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA. PMID: 11983918.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    129. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002 Apr 29; 157(3):493-507. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL. PMID: 11970960.
      View in: PubMed   Mentions: 255     Fields:    Translation:HumansAnimalsCells
    130. Killed by leukocytes that don't know when to leave. Nat Immunol. 2002 Apr; 3(4):337-8. Sheppard D. PMID: 11919573.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    131. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002 Apr 01; 157(1):149-60. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA. PMID: 11927607.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    132. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem. 2002 May 17; 277(20):17804-10. Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y. PMID: 11882657.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    133. Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema. Chest. 2002 Mar; 121(3 Suppl):21S-25S. Sheppard D. PMID: 11893658.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    134. Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans. Chest. 2002 Mar; 121(3 Suppl):31S-32S. Kaminski N, Zuo F, Cojocaro G, Yakhini Z, Ben-Dor A, Morris D, Sheppard D, Pardo A, Selman M, Heller RA. PMID: 11893671.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    135. The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J Biol Chem. 2002 Apr 26; 277(17):14467-74. Liao YF, Gotwals PJ, Koteliansky VE, Sheppard D, Van De Water L. PMID: 11839764.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    136. Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus. J Virol. 2002 Feb; 76(3):935-41. Jackson T, Mould AP, Sheppard D, King AM. PMID: 11773368.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    137. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med. 2002 Jan; 8(1):27-34. Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. PMID: 11786903.
      View in: PubMed   Mentions: 205     Fields:    Translation:Animals
    138. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001 Nov; 49(11):1341-50. Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC. PMID: 11668187.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    139. The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner. Mol Biol Cell. 2001 Oct; 12(10):3214-25. Young BA, Taooka Y, Liu S, Askins KJ, Yokosaki Y, Thomas SM, Sheppard D. PMID: 11598204.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    140. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):474-85. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. PMID: 11694453.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    141. Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells. J Invest Dermatol. 2001 Jul; 117(1):67-73. Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF. PMID: 11442751.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    142. Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis. Chest. 2001 Jul; 120(1 Suppl):49S-53S. Sheppard D. PMID: 11451914.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    143. Pulmonary fibrosis: a cellular overreaction or a failure of communication? J Clin Invest. 2001 Jun; 107(12):1501-2. Sheppard D. PMID: 11413155.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    144. TGF-beta is a critical mediator of acute lung injury. J Clin Invest. 2001 Jun; 107(12):1537-44. Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D. PMID: 11413161.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    145. Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus. J Virol. 2001 May; 75(9):4158-64. Miller LC, Blakemore W, Sheppard D, Atakilit A, King AM, Jackson T. PMID: 11287565.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    146. Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium. J Histochem Cytochem. 2001 Jan; 49(1):41-8. Miller LA, Barnett NL, Sheppard D, Hyde DM. PMID: 11118477.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    147. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem. 2000 Nov 10; 275(45):34922-30. Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y. PMID: 10944520.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    148. Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin. J Biol Chem. 2000 Oct 13; 275(41):31930-7. Marcinkiewicz C, Taooka Y, Yokosaki Y, Calvete JJ, Marcinkiewicz MM, Lobb RR, Niewiarowski S, Sheppard D. PMID: 10926928.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    149. A primary culture model of differentiated murine tracheal epithelium. Am J Physiol Lung Cell Mol Physiol. 2000 Oct; 279(4):L766-78. Davidson DJ, Kilanowski FM, Randell SH, Sheppard DN, Dorin JR. PMID: 11000138.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    150. Functional genomics and expression profiling: be there or be square. Am J Respir Cell Mol Biol. 2000 Sep; 23(3):265-9. Albelda SM, Sheppard D. PMID: 10970813.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    151. Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1. J Biol Chem. 2000 Aug 04; 275(31):23589-95. Takahashi H, Isobe T, Horibe S, Takagi J, Yokosaki Y, Sheppard D, Saito Y. PMID: 10816592.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    152. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol. 2000 Jul; 20(14):5208-15. Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D. PMID: 10866676.
      View in: PubMed   Mentions: 92     Fields:    Translation:Animals
    153. In vivo functions of integrins: lessons from null mutations in mice. Matrix Biol. 2000 Jul; 19(3):203-9. Sheppard D. PMID: 10936445.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    154. The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus. J Virol. 2000 Jun; 74(11):4949-56. Jackson T, Sheppard D, Denyer M, Blakemore W, King AM. PMID: 10799568.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    155. Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair. Trends Cardiovasc Med. 2000 May; 10(4):155-9. Yokasaki Y, Sheppard D. PMID: 11239795.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    156. Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line. J Physiol. 2000 Apr 15; 524 Pt 2:317-30. Lansdell KA, Cai Z, Kidd JF, Sheppard DN. PMID: 10766914.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    157. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1778-83. Kaminski N, Allard JD, Pittet JF, Zuo F, Griffiths MJ, Morris D, Huang X, Sheppard D, Heller RA. PMID: 10677534.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    158. Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Mol Cell Biol. 2000 Feb; 20(3):755-9. Huang X, Griffiths M, Wu J, Farese RV, Sheppard D. PMID: 10629031.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    159. The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem. 1999 Dec 17; 274(51):36328-34. Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D. PMID: 10593924.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    160. Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration. J Cell Sci. 1999 Dec; 112 ( Pt 23):4271-9. Milner R, Huang X, Wu J, Nishimura S, Pytela R, Sheppard D, ffrench-Constant C. PMID: 10564645.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    161. Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA. Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3108-15. Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, Brown DJ. PMID: 10586931.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    162. Inhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents. Br J Pharmacol. 1999 Sep; 128(1):108-18. Cai Z, Lansdell KA, Sheppard DN. PMID: 10498841.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    163. Airway remodeling and repair. Am J Respir Crit Care Med. 1999 Sep; 160(3):1035-42. Busse W, Elias J, Sheppard D, Banks-Schlegel S. PMID: 10471638.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    164. Fibronectin and alpha5beta1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium. Eur Respir J. 1999 Jun; 13(6):1301-9. Roger P, Puchelle E, Bajolet-Laudinat O, Tournier JM, Debordeaux C, Plotkowski MC, Cohen JH, Sheppard D, de Bentzmann S. PMID: 10445605.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    165. The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1. J Cell Biol. 1999 Apr 19; 145(2):413-20. Taooka Y, Chen J, Yednock T, Sheppard D. PMID: 10209034.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    166. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999 Feb 05; 96(3):319-28. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. PMID: 10025398.
      View in: PubMed   Mentions: 615     Fields:    Translation:HumansAnimalsCells
    167. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998 Dec 18; 282(5397):2261-3. Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. PMID: 9856950.
      View in: PubMed   Mentions: 490     Fields:    Translation:HumansAnimalsCells
    168. Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation. J Cell Biochem. 1998 Dec 15; 71(4):536-45. Desloges N, Basora N, Perreault N, Bouatrouss Y, Sheppard D, Beaulieu JF. PMID: 9827699.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    169. Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice. Am J Respir Cell Mol Biol. 1998 Oct; 19(4):636-42. Huang X, Wu J, Zhu W, Pytela R, Sheppard D. PMID: 9761761.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    170. Airway epithelial integrins: why so many? Am J Respir Cell Mol Biol. 1998 Sep; 19(3):349-51. Sheppard D. PMID: 9730861.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    171. The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. J Cell Sci. 1998 Aug; 111 ( Pt 15):2189-95. Huang X, Wu J, Spong S, Sheppard D. PMID: 9664040.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    172. A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins. FEBS Lett. 1998 Jun 16; 429(3):269-73. Schneider H, Harbottle RP, Yokosaki Y, Kunde J, Sheppard D, Coutelle C. PMID: 9662430.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    173. Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C. J Biol Chem. 1998 May 08; 273(19):11423-8. Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, Shigeto N, Chen J, Sheppard D. PMID: 9565552.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    174. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol Med. 1998 May; 4(5):344-55. Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. PMID: 9642684.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    175. Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells. J Physiol. 1998 Apr 15; 508 ( Pt 2):379-92. Lansdell KA, Delaney SJ, Lunn DP, Thomson SA, Sheppard DN, Wainwright BJ. PMID: 9508803.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    176. Expression of the alpha9beta1 integrin in human colonic epithelial cells: resurgence of the fetal phenotype in a subset of colon cancers and adenocarcinoma cell lines. Int J Cancer. 1998 Mar 02; 75(5):738-43. Basora N, Desloges N, Chang Q, Bouatrouss Y, Gosselin J, Poisson J, Sheppard D, Beaulieu JF. PMID: 9495242.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    177. Epidermal integrin expression is upregulated rapidly in human fetal wound repair. J Pediatr Surg. 1998 Feb; 33(2):312-6. Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS. PMID: 9498408.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    178. Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells. Virology. 1997 Dec 08; 239(1):71-7. Agrez MV, Shafren DR, Gu X, Cox K, Sheppard D, Barry RD. PMID: 9426447.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    179. Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C. Int J Cancer. 1997 Jul 17; 72(2):369-76. Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R. PMID: 9219848.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    180. Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin. J Biol Chem. 1996 Nov 08; 271(45):28485-91. Smith LL, Cheung HK, Ling LE, Chen J, Sheppard D, Pytela R, Giachelli CM. PMID: 8910476.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    181. Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium. Am J Physiol. 1996 Nov; 271(5 Pt 1):L726-33. Hérard AL, Pierrot D, Hinnrasky J, Kaplan H, Sheppard D, Puchelle E, Zahm JM. PMID: 8944715.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    182. Differential regulation of airway epithelial integrins by growth factors. Am J Respir Cell Mol Biol. 1996 Nov; 15(5):664-72. Wang A, Yokosaki Y, Ferrando R, Balmes J, Sheppard D. PMID: 8918373.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    183. Distinct structural requirements for interaction of the integrins alpha 5 beta 1, alpha v beta 5, and alpha v beta 6 with the central cell binding domain in fibronectin. Cell Adhes Commun. 1996 Nov; 4(4-5):237-50. Chen J, Maeda T, Sekiguchi K, Sheppard D. PMID: 9117344.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    184. Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture. J Biol Chem. 1996 Oct 18; 271(42):25976-80. Dixit RB, Chen A, Chen J, Sheppard D. PMID: 8824234.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    185. Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains. J Biol Chem. 1996 Sep 27; 271(39):24144-50. Yokosaki Y, Monis H, Chen J, Sheppard D. PMID: 8798654.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    186. Epithelial integrins. Bioessays. 1996 Aug; 18(8):655-60. Sheppard D. PMID: 8760339.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    187. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May; 133(4):921-8. Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D. PMID: 8666675.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    188. Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer. Br J Cancer. 1996 Apr; 73(7):887-92. Agrez MV, Bates RC, Mitchell D, Wilson N, Ferguson N, Anseline P, Sheppard D. PMID: 8611401.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    189. Expression of the integrin subunit alpha 9 in the murine embryo. Dev Dyn. 1995 Dec; 204(4):421-31. Wang A, Patrone L, McDonald JA, Sheppard D. PMID: 8601035.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    190. Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells. Exp Cell Res. 1995 Dec; 221(2):385-94. Kumar NM, Sigurdson SL, Sheppard D, Lwebuga-Mukasa JS. PMID: 7493638.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    191. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5. J Clin Invest. 1995 Oct; 96(4):1987-2001. Boylan AM, Sanan DA, Sheppard D, Broaddus VC. PMID: 7560092.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    192. The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J Biol Chem. 1995 Sep 29; 270(39):23196-202. Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R. PMID: 7559467.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    193. A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts. Am J Respir Cell Mol Biol. 1995 Aug; 13(2):245-51. Huang XZ, Chen A, Agrez M, Sheppard D. PMID: 7626292.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    194. Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways. Am J Respir Cell Mol Biol. 1995 May; 12(5):547-56. Weinacker A, Ferrando R, Elliott M, Hogg J, Balmes J, Sheppard D. PMID: 7537970.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    195. Localized distribution of alpha 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation. J Histochem Cytochem. 1995 Apr; 43(4):353-62. Stepp MA, Zhu L, Sheppard D, Cranfill RL. PMID: 7534781.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    196. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. J Cell Sci. 1995 Feb; 108 ( Pt 2):537-44. Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R. PMID: 7768999.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    197. Localization of the alpha v subfamily of integrins and their putative ligands in synovial lining cell layer. J Rheumatol. 1995 Jan; 22(1):16-23. Nikkari L, Haapasalmi K, Aho H, Torvinen A, Sheppard D, Larjava H, Heino J. PMID: 7535359.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    198. Staphylococcus aureus stimulates neutrophil recruitment by stimulating interleukin-8 production in dog trachea. Am J Physiol. 1995 Jan; 268(1 Pt 1):L85-94. Massion PP, Hébert CA, Leong S, Chan B, Inoue H, Grattan K, Sheppard D, Nadel JA. PMID: 7840233.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    199. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. J Biol Chem. 1994 Nov 18; 269(46):28708-15. Nishimura SL, Sheppard D, Pytela R. PMID: 7525578.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    200. The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. J Biol Chem. 1994 Oct 28; 269(43):26691-6. Yokosaki Y, Palmer EL, Prieto AL, Crossin KL, Bourdon MA, Pytela R, Sheppard D. PMID: 7523411.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    201. The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain. J Cell Biol. 1994 Oct; 127(2):547-56. Agrez M, Chen A, Cone RI, Pytela R, Sheppard D. PMID: 7929593.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    202. Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain. J Biol Chem. 1994 Jul 15; 269(28):18311-4. Lukashev ME, Sheppard D, Pytela R. PMID: 7518428.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    203. Dominant negative mutants: tools for the study of protein function in vitro and in vivo. Am J Respir Cell Mol Biol. 1994 Jul; 11(1):1-6. Sheppard D. PMID: 8018332.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    204. Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts. Cell Adhes Commun. 1994 Jun; 2(2):101-13. Cone RI, Weinacker A, Chen A, Sheppard D. PMID: 8081887.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    205. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994 Mar 04; 269(9):6940-8. Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D. PMID: 8120056.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    206. Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules. Methods Enzymol. 1994; 245:420-51. Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D. PMID: 7760745.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    207. Identification and characterization of novel airway epithelial integrins. Am Rev Respir Dis. 1993 Dec; 148(6 Pt 2):S38-42. Sheppard D. PMID: 8256923.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    208. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. J Cell Biol. 1993 Dec; 123(5):1289-97. Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D. PMID: 8245132.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    209. Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. J Histochem Cytochem. 1993 Oct; 41(10):1521-7. Breuss JM, Gillett N, Lu L, Sheppard D, Pytela R. PMID: 8245410.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    210. Occupational asthma in a pesticides manufacturing worker. Chest. 1993 Jan; 103(1):295-6. Royce S, Wald P, Sheppard D, Balmes J. PMID: 8417906.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    211. Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells. J Biol Chem. 1992 Aug 25; 267(24):17409-14. Sheppard D, Cohen DS, Wang A, Busk M. PMID: 1512272.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    212. Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. J Biol Chem. 1992 Mar 25; 267(9):5790-6. Busk M, Pytela R, Sheppard D. PMID: 1532572.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    213. Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction. Chest. 1992 Mar; 101(3 Suppl):49S. Sheppard D, Erle D, Busk M, Pytela R. PMID: 1541204.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    214. Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin. Br J Ind Med. 1991 Sep; 48(9):629-35. Gordon T, Balmes J, Fine J, Sheppard D. PMID: 1911406.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    215. Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor. J Biol Chem. 1991 Aug 25; 266(24):15598-601. Wang A, Cohen DS, Palmer E, Sheppard D. PMID: 1874718.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    216. Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):170-7. Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R. PMID: 1892648.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    217. The response of guinea pig airway epithelial cells and alveolar macrophages to environmental stress. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):133-43. Cohen DS, Palmer E, Welch WJ, Sheppard D. PMID: 1892643.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    218. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. J Biol Chem. 1991 Jun 15; 266(17):11009-16. Erle DJ, Rüegg C, Sheppard D, Pytela R. PMID: 2040616.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    219. Lack of bronchoconstrictor response to sulfuric acid aerosols and fogs. Am Rev Respir Dis. 1991 Apr; 143(4 Pt 1):744-50. Aris R, Christian D, Sheppard D, Balmes JR. PMID: 2008986.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    220. The effects of sequential exposure to acidic fog and ozone on pulmonary function in exercising subjects. Am Rev Respir Dis. 1991 Jan; 143(1):85-91. Aris R, Christian D, Sheppard D, Balmes JR. PMID: 1846067.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    221. Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. J Biol Chem. 1990 Jul 15; 265(20):11502-7. Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R. PMID: 2365683.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    222. Acid fog-induced bronchoconstriction. The role of hydroxymethanesulfonic acid. Am Rev Respir Dis. 1990 Mar; 141(3):546-51. Aris R, Christian D, Sheppard D, Balmes JR. PMID: 2155554.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    223. Potential bronchoconstrictor stimuli in acid fog. Environ Health Perspect. 1989 Feb; 79:163-6. Balmes JR, Fine JM, Gordon T, Sheppard D. PMID: 2539989.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    224. Epithelium removal alters responsiveness of guinea pig trachea to substance P. J Appl Physiol (1985). 1989 Jan; 66(1):232-7. Fine JM, Gordon T, Sheppard D. PMID: 2465289.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    225. Sulfur dioxide and asthma--a double-edged sword? J Allergy Clin Immunol. 1988 Dec; 82(6):961-4. Sheppard D. PMID: 3060513.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    226. A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. Am Rev Respir Dis. 1988 Sep; 138(3):547-51. Sheppard D, Scypinski L. PMID: 2462379.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    227. Acidity potentiates bronchoconstriction induced by hypoosmolar aerosols. Am Rev Respir Dis. 1988 Jul; 138(1):35-9. Balmes JR, Fine JM, Christian D, Gordon T, Sheppard D. PMID: 2849338.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    228. Arachidonic acid metabolites do not mediate toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. Prostaglandins. 1988 May; 35(5):699-706. Gordon T, Thompson JE, Sheppard D. PMID: 2840688.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    229. Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase. J Clin Invest. 1988 Apr; 81(4):1111-5. Sheppard D, Thompson JE, Scypinski L, Dusser D, Nadel JA, Borson DB. PMID: 2450892.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    230. Tumor necrosis factor inhibits a polymorphonuclear leukocyte-dependent airway edema in guinea pigs. J Appl Physiol (1985). 1988 Apr; 64(4):1688-92. Gordon T, Sheppard D. PMID: 2837454.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    231. Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction. Chest. 1988 Mar; 93(3):476-81. Turner JR, Corkery KJ, Eckman D, Gelb AM, Lipavsky A, Sheppard D. PMID: 3342656.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    232. Phosphoramidon potentiates the increase in lung resistance mediated by tachykinins in guinea pigs. Am Rev Respir Dis. 1988 Feb; 137(2):337-40. Thompson JE, Sheppard D. PMID: 2449105.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    233. Karyotypic analysis of the human monoblastic cell line U937. Cancer Genet Cytogenet. 1988 Feb; 30(2):277-84. Shipley JM, Sheppard DM, Sheer D. PMID: 3422581.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    234. Mechanisms of acute increases in airway responsiveness caused by environmental chemicals. J Allergy Clin Immunol. 1988 Jan; 81(1):128-32. Sheppard D. PMID: 2828449.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    235. The roles of pH and ionic species in sulfur dioxide- and sulfite-induced bronchoconstriction. Am Rev Respir Dis. 1987 Nov; 136(5):1122-6. Fine JM, Gordon T, Sheppard D. PMID: 3674574.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    236. Symptomatic bronchoconstriction after short-term inhalation of sulfur dioxide. Am Rev Respir Dis. 1987 Nov; 136(5):1117-21. Balmes JR, Fine JM, Sheppard D. PMID: 3674573.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    237. What does exercise have to do with "exercise-induced" asthma? Am Rev Respir Dis. 1987 Sep; 136(3):547-9. Sheppard D. PMID: 3631726.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    238. Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs. Am Rev Respir Dis. 1987 Jul; 136(1):43-9. Thompson JE, Scypinski LA, Gordon T, Sheppard D. PMID: 2440357.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    239. Apparent effect of catalase on airway edema in guinea pigs. Role of endotoxin contamination. Am Rev Respir Dis. 1987 Apr; 135(4):854-9. Gordon T, Milligan SA, Levin J, Thompson JE, Fine JM, Sheppard D. PMID: 3032030.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    240. The role of titratable acidity in acid aerosol-induced bronchoconstriction. Am Rev Respir Dis. 1987 Apr; 135(4):826-30. Fine JM, Gordon T, Thompson JE, Sheppard D. PMID: 3551704.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    241. Physiology of the parasympathetic nervous system of the lung. Postgrad Med J. 1987; 63 Suppl 1:21-7. Sheppard D. PMID: 3321011.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    242. Hydroxyurea inhibits airway hyperresponsiveness in guinea pigs by a granulocyte-independent mechanism. Am Rev Respir Dis. 1986 Dec; 134(6):1213-8. Thompson JE, Scypinski LA, Gordon T, Sheppard D. PMID: 3024538.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    243. Mechanisms of bronchoconstriction from nonimmunologic environmental stimuli. Chest. 1986 Oct; 90(4):584-7. Sheppard D. PMID: 3757569.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    244. Interaction of cromolyn and a muscarinic antagonist in inhibiting bronchial reactivity to sulfur dioxide and to eucapnic hyperpnea alone. Am Rev Respir Dis. 1986 Jun; 133(6):1154-8. Myers DJ, Bigby BG, Calvayrac P, Sheppard D, Boushey HA. PMID: 2940953.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    245. Granulocyte-mediated airway edema in guinea pigs. J Appl Physiol (1985). 1986 Apr; 60(4):1213-20. Sheppard D, Scypinski L, Horn J, Gordon T, Thompson JE. PMID: 3009387.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    246. The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Am Rev Respir Dis. 1986 Apr; 133(4):515-8. Bigby TD, Margolskee D, Curtis JL, Michael PF, Sheppard D, Hadley WK, Hopewell PC. PMID: 3485945.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    247. Effects of esmolol on airway function in patients with asthma. J Clin Pharmacol. 1986 Mar; 26(3):169-74. Sheppard D, DiStefano S, Byrd RC, Eschenbacher WL, Bell V, Steck J, Laddu A. PMID: 2870080.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    248. Acute effects of routine firefighting on lung function. Am J Ind Med. 1986; 9(4):333-40. Sheppard D, Distefano S, Morse L, Becker C. PMID: 3518426.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    249. Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs. Am Rev Respir Dis. 1985 Nov; 132(5):1106-12. Gordon T, Sheppard D, McDonald DM, Distefano S, Scypinski L. PMID: 2998244.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    250. Effect of eucapnic hypoxia on bronchomotor tone and on the bronchomotor response to dry air in asthmatic subjects. Am Rev Respir Dis. 1985 Sep; 132(3):690-3. Tam EK, Geffroy BA, Myers DJ, Seltzer J, Sheppard D, Boushey HA. PMID: 3929659.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    251. Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma. Am Rev Respir Dis. 1985 Aug; 132(2):283-6. Siegel D, Sheppard D, Gelb A, Weinberg PF. PMID: 2862819.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
    252. Respiratory heat loss is not the sole stimulus for bronchoconstriction induced by isocapnic hyperpnea with dry air. Am Rev Respir Dis. 1985 Jun; 131(6):894-901. Eschenbacher WL, Sheppard D. PMID: 3923883.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    253. Pharmacotherapy of asthma. West J Med. 1985 May; 142(5):700-2. Sheppard D. PMID: 2861694.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    254. Effect of 0.25 ppm sulfur dioxide on airway resistance in freely breathing, heavily exercising, asthmatic subjects. Am Rev Respir Dis. 1985 Apr; 131(4):659-61. Bethel RA, Sheppard D, Geffroy B, Tam E, Nadel JA, Boushey HA. PMID: 3994163.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    255. Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma. Environ Res. 1984 Oct; 35(1):133-9. Sheppard D, Eschenbacher WL, Epstein J. PMID: 6489284.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    256. Morphine sulfate inhibits bronchoconstriction in subjects with mild asthma whose responses are inhibited by atropine. Am Rev Respir Dis. 1984 Sep; 130(3):363-7. Eschenbacher WL, Bethel RA, Boushey HA, Sheppard D. PMID: 6476586.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    257. Interaction of sulfur dioxide and dry cold air in causing bronchoconstriction in asthmatic subjects. J Appl Physiol Respir Environ Exerc Physiol. 1984 Aug; 57(2):419-23. Bethel RA, Sheppard D, Epstein J, Tam E, Nadel JA, Boushey HA. PMID: 6469811.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    258. Magnitude of the interaction between the bronchomotor effects of sulfur dioxide and those of dry (cold) air. Am Rev Respir Dis. 1984 Jul; 130(1):52-5. Sheppard D, Eschenbacher WL, Boushey HA, Bethel RA. PMID: 6742611.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    259. Respiratory water loss as a stimulus to exercise-induced bronchoconstriction. J Allergy Clin Immunol. 1984 May; 73(5 Pt 2):640-2. Sheppard D, Eschenbacher WL. PMID: 6715729.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    260. Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis. 1984 Feb; 129(2):211-5. Eschenbacher WL, Boushey HA, Sheppard D. PMID: 6696320.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    261. Variable inhibition of histamine-induced bronchoconstriction by atropine in subjects with asthma. J Allergy Clin Immunol. 1984 Jan; 73(1 Pt 1):82-7. Sheppard D, Epstein J, Skoogh BE, Bethel RA, Nadel JA, Boushey HA. PMID: 6363488.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    262. Sulfur dioxide-induced bronchoconstriction in freely breathing, exercising, asthmatic subjects. Am Rev Respir Dis. 1983 Dec; 128(6):987-90. Bethel RA, Epstein J, Sheppard D, Nadel JA, Boushey HA. PMID: 6650990.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    263. Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1983 Oct; 128(4):592-6. Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA. PMID: 6354021.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    264. Antihistaminic versus anticholinergic effects of atropine on canine trachealis muscle. Am Rev Respir Dis. 1983 Oct; 128(4):603-6. Skoogh BE, Nadel JA, Fabbri LM, Sheppard D, Holtzman MJ. PMID: 6137986.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    265. Purification of uroporphyrinogen decarboxylase from human erythrocytes. Immunochemical evidence for a single protein with decarboxylase activity in human erythrocytes and liver. Biochem J. 1983 Oct 01; 215(1):45-55. Elder GH, Tovey JA, Sheppard DM. PMID: 6626181.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    266. Chest pain and hypoxemia from inhalation of a trichloroethane aerosol product. J Toxicol Clin Toxicol. 1983 Jun; 20(4):333-41. Woo OF, Healey KM, Sheppard D, Tong TG. PMID: 6689182.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    267. Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis. 1983 Jun; 127(6):691-4. Sheppard D, Rizk NW, Boushey HA, Bethel RA. PMID: 6407371.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    268. Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma. Environ Res. 1983 Apr; 30(2):412-9. Sheppard D, Epstein J, Bethel RA, Nadel JA, Boushey HA. PMID: 6832125.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    269. Effect of route of atropine delivery on bronchospasm from cold air and methacholine. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):130-3. Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. PMID: 6337982.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    270. Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):134-9. Holtzman MJ, McNamara MP, Sheppard D, Fabbri LM, Hahn HL, Graf PD, Nadel JA. PMID: 6826397.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    271. Occupational asthma. West J Med. 1982 Dec; 137(6):480-5. Sheppard D. PMID: 7164429.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    272. Effect of the oronasal breathing route on sulfur dioxide-induced bronchoconstriction in exercising asthmatic subjects. Am Rev Respir Dis. 1982 Jun; 125(6):627-31. Kirkpatrick MB, Sheppard D, Nadel JA, Boushey HA. PMID: 7091868.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    273. Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects. Am Rev Respir Dis. 1981 Sep; 124(3):257-9. Sheppard D, Nadel JA, Boushey HA. PMID: 6792956.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    274. Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1981 May; 123(5):486-91. Sheppard D, Saisho A, Nadel JA, Boushey HA. PMID: 7235370.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    275. Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Am Rev Respir Dis. 1980 Dec; 122(6):873-8. Sheppard D, Wong WS, Uehara CF, Nadel JA, Boushey HA. PMID: 7458061.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
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