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IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle. Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34):e2401251121.
Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB. PMID: 39136993.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis. Nature. 2024 Jul 10.
Tsukui T, Wolters PJ, Sheppard D. PMID: 38987592.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle. bioRxiv. 2024 May 01.
Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB. PMID: 38746410; PMCID: PMC11092608.
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The Puerto Rican Infant Metagenomic and Epidemiologic Study of Respiratory Outcomes (PRIMERO): Design and Baseline Characteristics for a Birth Cohort Study of Early-life Viral Respiratory Illnesses and Airway Dysfunction in Puerto Rican Children. medRxiv. 2024 Apr 16.
Witonsky JI, Elhawary JR, Eng C, Oh SS, Salazar S, Contreras MG, Medina V, Secor EA, Zhang P, Everman JL, Fairbanks-Mahnke A, Pruesse E, Sajuthi SP, Chang CH, Guerrero TR, Fuentes KC, Lopez N, Montanez-Lopez CA, Otero RA, Rivera RC, Rodriguez L, Vazquez G, Hu D, Huntsman S, Jackson ND, Li Y, Morin A, Nieves NA, Rios C, Serrano G, Williams BJM, Ziv E, Moore CM, Sheppard D, Burchard EG, Seibold MA, Rodriguez Santana JR. PMID: 38699325; PMCID: PMC11065009.
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PubMed Mentions:
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An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis. J Clin Invest. 2024 Mar 07; 134(9).
Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T. PMID: 38451724; PMCID: PMC11060735.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Mast cells help organize the Peyer's patch niche for induction of IgA responses. Sci Immunol. 2024 Mar; 9(93):eadj7363.
De Giovanni M, Vykunta VS, Biram A, Chen KY, Taglinao H, An J, Sheppard D, Paidassi H, Cyster JG. PMID: 38427721; PMCID: PMC11008922.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report. Ann Am Thorac Soc. 2024 Jan; 21(1):1-11.
Vukmirovic M, Benam KH, Rose JJ, Turner S, Magin CM, Lagares D, Cohen AH, Kaminski N, Hirota JA, Maher TM, Konigshoff M, Mallampalli RK, Sheppard D, Tarran R, Gomer RH, Kenyon NJ, Morris D, Hobbie S, Raju SV, Petrache I, Watkins T, Kumar R, Lam WA, Sherer T, Hecker L. PMID: 37903340; PMCID: PMC10867911.
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PubMed Mentions: Fields:
Translation:
Humans
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Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification. bioRxiv. 2023 Dec 23.
Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D. PMID: 38187712; PMCID: PMC10769348.
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PubMed Mentions:
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APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. Nat Immunol. 2023 Nov; 24(11):1839-1853.
Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. PMID: 37749326; PMCID: PMC10863749.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling. bioRxiv. 2023 Sep 21.
McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky O, Arnold TD. PMID: 37790363; PMCID: PMC10542141.
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TGF-β signaling in health and disease. Cell. 2023 09 14; 186(19):4007-4037.
Massagué J, Sheppard D. PMID: 37714133; PMCID: PMC10772989.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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An immune-based tool platform for in vivo cell clearance. Life Sci Alliance. 2023 08; 6(8).
Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL. PMID: 37311583; PMCID: PMC10264967.
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HumansCells
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An integrated cell atlas of the lung in health and disease. Nat Med. 2023 Jun; 29(6):1563-1577.
Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, Markov NS, Zaragosi LE, Ji Y, Ansari M, Arguel MJ, Apperloo L, Banchero M, Bécavin C, Berg M, Chichelnitskiy E, Chung MI, Collin A, Gay ACA, Gote-Schniering J, Hooshiar Kashani B, Inecik K, Jain M, Kapellos TS, Kole TM, Leroy S, Mayr CH, Oliver AJ, von Papen M, Peter L, Taylor CJ, Walzthoeni T, Xu C, Bui LT, De Donno C, Dony L, Faiz A, Guo M, Gutierrez AJ, Heumos L, Huang N, Ibarra IL, Jackson ND, Kadur Lakshminarasimha Murthy P, Lotfollahi M, Tabib T, Talavera-López C, Travaglini KJ, Wilbrey-Clark A, Worlock KB, Yoshida M, Lung Biological Network Consortium, van den Berge M, Bossé Y, Desai TJ, Eickelberg O, Kaminski N, Krasnow MA, Lafyatis R, Nikolic MZ, Powell JE, Rajagopal J, Rojas M, Rozenblatt-Rosen O, Seibold MA, Sheppard D, Shepherd DP, Sin DD, Timens W, Tsankov AM, Whitsett J, Xu Y, Banovich NE, Barbry P, Duong TE, Falk CS, Meyer KB, Kropski JA, Pe'er D, Schiller HB, Tata PR, Schultze JL, Teichmann SA, Misharin AV, Nawijn MC, Luecken MD, Theis FJ. PMID: 37291214; PMCID: PMC10287567.
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PubMed Mentions:
94 Fields:
Translation:
HumansCells
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Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis. Gastroenterology. 2023 04; 164(4):619-629.
Livanos AE, Dunn A, Fischer J, Ungaro RC, Turpin W, Lee SH, Rui S, Del Valle DM, Jougon JJ, Martinez-Delgado G, Riddle MS, Murray JA, Laird RM, Torres J, Agrawal M, Magee JS, Dervieux T, Gnjatic S, Sheppard D, Sands BE, Porter CK, Croitoru K, Petralia F, CCC-GEM Project Research Consortium, OSCCAR Consortium, Colombel JF, Mehandru S. PMID: 36634824; PMCID: PMC10284061.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins. Int J Biol Sci. 2023; 19(1):156-166.
Monieri M, Rainone P, Sacchi A, Gori A, Gasparri AM, Coliva A, Citro A, Ferrara B, Policardi M, Valtorta S, Pocaterra A, Alfano M, Sheppard D, Piemonti L, Moresco RM, Corti A, Curnis F. PMID: 36594095; PMCID: PMC9760430.
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Translation:
HumansAnimals
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Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science. 2022 10 14; 378(6616):192-201.
Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T. PMID: 36227993; PMCID: PMC10621323.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. Front Immunol. 2022; 13:880887.
Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. PMID: 35634278; PMCID: PMC9134074.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Obesity alters pathology and treatment response in inflammatory disease. Nature. 2022 04; 604(7905):337-342.
Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. PMID: 35355021; PMCID: PMC9165753.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2022 04 01; 322(4):L564-L580.
Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR. PMID: 35170357; PMCID: PMC8957349.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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αVβ8 integrin targeting to prevent posterior capsular opacification. JCI Insight. 2021 11 08; 6(21).
Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK. PMID: 34554928; PMCID: PMC8663568.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation. Nat Commun. 2021 10 28; 12(1):6228.
Lainé A, Labiad O, Hernandez-Vargas H, This S, Sanlaville A, Léon S, Dalle S, Sheppard D, Travis MA, Paidassi H, Marie JC. PMID: 34711823; PMCID: PMC8553942.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Cell Rep. 2021 07 06; 36(1):109309.
Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D. PMID: 34233193; PMCID: PMC8321414.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. J Clin Invest. 2021 06 15; 131(12).
Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB. PMID: 33956668; PMCID: PMC8203456.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis? Am J Respir Crit Care Med. 2021 03 15; 203(6):667-669.
Auyeung VC, Sheppard D. PMID: 33226835; PMCID: PMC7958518.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis. J Pathol. 2021 04; 253(4):366-373.
Nishimichi N, Tsujino K, Kanno K, Sentani K, Kobayashi T, Chayama K, Sheppard D, Yokosaki Y. PMID: 33433924; PMCID: PMC7986747.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21).
Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. PMID: 32990679; PMCID: PMC7710308.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020 11; 22(11):1295-1306.
Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T. PMID: 33046884; PMCID: PMC7642162.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 11 15; 30(22):127578.
Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. PMID: 33007395; PMCID: PMC7700746.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557).
Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. PMID: 32817366; PMCID: PMC7976849.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier. J Clin Invest. 2020 08 03; 130(8):4055-4068.
Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD. PMID: 32369453; PMCID: PMC7410045.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat Commun. 2020 04 21; 11(1):1920.
Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D. PMID: 32317643; PMCID: PMC7174390.
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PubMed Mentions:
219 Fields:
Translation:
HumansAnimalsCells
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Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Sci Adv. 2020 02; 6(7):eaay7667.
Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK. PMID: 32095531; PMCID: PMC7015688.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion. J Biol Chem. 2019 11 29; 294(48):18232-18243.
Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB. PMID: 31640988; PMCID: PMC6885615.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction. J Exp Med. 2019 04 01; 216(4):900-915.
Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D. PMID: 30846482; PMCID: PMC6446869.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma. Int J Cancer. 2019 08 01; 145(3):678-685.
Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M. PMID: 30653264.
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PubMed Mentions:
21 Fields:
Translation:
Humans
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IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility. J Immunol. 2019 03 01; 202(5):1540-1548.
Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X. PMID: 30683702; PMCID: PMC6379809.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019; 14(1):e0209824.
Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. PMID: 30625178; PMCID: PMC6326459.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration. Am J Pathol. 2019 02; 189(2):258-271.
Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC. PMID: 30448409; PMCID: PMC6360354.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 11 02; 3(21).
Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M. PMID: 30385725; PMCID: PMC6238747.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation. Am J Physiol Lung Cell Mol Physiol. 2018 09 01; 315(3):L360-L370.
Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K. PMID: 29792348; PMCID: PMC6172619.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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TGF-β1 Signaling and Tissue Fibrosis. Cold Spring Harb Perspect Biol. 2018 04 02; 10(4).
Kim KK, Sheppard D, Chapman HA. PMID: 28432134; PMCID: PMC5880172.
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PubMed Mentions:
269 Fields:
Translation:
HumansAnimalsCells
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Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):E10161-E10168.
Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S. PMID: 29109269; PMCID: PMC5703296.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L878-L888.
Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D. PMID: 28818870; PMCID: PMC6842869.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 05; 56(5):667-679.
Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES, ATS Assembly on Respiratory Cell and Molecular Biology. PMID: 28459387; PMCID: PMC5800895.
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PubMed Mentions:
147 Fields:
Translation:
HumansAnimals
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Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. J Am Soc Nephrol. 2017 Jul; 28(7):1998-2005.
Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. PMID: 28220032; PMCID: PMC5491273.
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PubMed Mentions:
29 Fields:
Translation:
Animals
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Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 01 03; 127(1):365-374.
Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. PMID: 27918306; PMCID: PMC5199700.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L22-L31.
Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D. PMID: 27864286; PMCID: PMC5283926.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Oct 13; 7(10):902-907.
Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H. PMID: 27774126; PMCID: PMC5066160.
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PubMed Mentions:
7
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An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens. PLoS Pathog. 2016 08; 12(8):e1005804.
Meliopoulos VA, Van de Velde LA, Van de Velde NC, Karlsson EA, Neale G, Vogel P, Guy C, Sharma S, Duan S, Surman SL, Jones BG, Johnson MD, Bosio C, Jolly L, Jenkins RG, Hurwitz JL, Rosch JW, Sheppard D, Thomas PG, Murray PJ, Schultz-Cherry S. PMID: 27505057; PMCID: PMC4978498.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome. J Immunol. 2016 07 01; 197(1):97-107.
McAleer JP, Nguyen NL, Chen K, Kumar P, Ricks DM, Binnie M, Armentrout RA, Pociask DA, Hein A, Yu A, Vikram A, Bibby K, Umesaki Y, Rivera A, Sheppard D, Ouyang W, Hooper LV, Kolls JK. PMID: 27217583; PMCID: PMC4912941.
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PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
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IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822.
Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. PMID: 27174992; PMCID: PMC4890166.
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PubMed Mentions:
148 Fields:
Translation:
AnimalsCells
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α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L824-36.
Sun KH, Chang Y, Reed NI, Sheppard D. PMID: 26944089; PMCID: PMC4867351.
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PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
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Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β. Nat Immunol. 2016 Apr; 17(4):414-21.
Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. PMID: 26901152; PMCID: PMC5135085.
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PubMed Mentions:
123 Fields:
Translation:
HumansAnimalsCells
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Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma. Curr Rheumatol Rep. 2016 Jan; 18(1):4.
Tsujino K, Sheppard D. PMID: 26711695.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis. Hepatology. 2016 Jan; 63(1):217-32.
Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y. PMID: 26448099; PMCID: PMC5312042.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504.
Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. PMID: 26321127; PMCID: PMC4573906.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015 Jul 01; 195(1):87-95.
Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D. PMID: 26002979; PMCID: PMC4475475.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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The αvβ1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. PMID: 25995225; PMCID: PMC4461057.
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PubMed Mentions:
125 Fields:
Translation:
AnimalsCells
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Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-β activation by epithelial cells and fibroblasts. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S21-3.
Sheppard D. PMID: 25830829; PMCID: PMC4430968.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37.
Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. PMID: 25526531; PMCID: PMC4273650.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain. Development. 2014 Dec; 141(23):4489-99.
Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. PMID: 25406396; PMCID: PMC4302931.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8.
Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. PMID: 25271629; PMCID: PMC4347230.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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The cell biology of asthma. J Cell Biol. 2014 Jun 09; 205(5):621-31.
Erle DJ, Sheppard D. PMID: 24914235; PMCID: PMC4050726.
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PubMed Mentions:
126 Fields:
Translation:
HumansAnimalsCells
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Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3080-5.
Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. PMID: 24516133; PMCID: PMC3939877.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15; 306(8):L726-35.
Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD. PMID: 24508732; PMCID: PMC3989722.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
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Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22.
Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. PMID: 24160862; PMCID: PMC3983890.
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PubMed Mentions:
130 Fields:
Translation:
HumansAnimalsCells
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TGF-β activation and function in immunity. Annu Rev Immunol. 2014; 32:51-82.
Travis MA, Sheppard D. PMID: 24313777; PMCID: PMC4010192.
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PubMed Mentions:
401 Fields:
Translation:
HumansAnimalsCells
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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24.
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. PMID: 24216753; PMCID: PMC3855865.
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PubMed Mentions:
421 Fields:
Translation:
AnimalsCells
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Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9914-9.
Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. PMID: 23716700; PMCID: PMC3683773.
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PubMed Mentions:
139 Fields:
Translation:
AnimalsCells
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The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May; 123(5):2037-48.
Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. PMID: 23543053; PMCID: PMC3635736.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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ROCKing pulmonary fibrosis. J Clin Invest. 2013 Mar; 123(3):1005-6.
Sheppard D. PMID: 23434586; PMCID: PMC3582155.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5. Crit Care Med. 2013 Feb; 41(2):546-53.
Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. PMID: 23263571.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med. 2013 Jan 09; 5(167):167sr1.
Friedman SL, Sheppard D, Duffield JS, Violette S. PMID: 23303606.
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PubMed Mentions:
326 Fields:
Translation:
HumansCells
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Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18042-7.
Freimuth J, Clermont FF, Huang X, DeSapio A, Tokuyasu TA, Sheppard D, Akhurst RJ. PMID: 23064636; PMCID: PMC3497801.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Integrin-mediated regulation of TGFβ in fibrosis. Biochim Biophys Acta. 2013 Jul; 1832(7):891-6.
Henderson NC, Sheppard D. PMID: 23046811; PMCID: PMC3573259.
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PubMed Mentions:
95 Fields:
Translation:
Humans
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Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9.
Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. PMID: 22988107; PMCID: PMC3479591.
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PubMed Mentions:
174 Fields:
Translation:
HumansAnimalsCells
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Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest. 2012 Aug; 122(8):2916-27.
Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. PMID: 22772469; PMCID: PMC3448403.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Modulation of acute lung injury by integrins. Proc Am Thorac Soc. 2012 Jul; 9(3):126-9.
Sheppard D. PMID: 22802286; PMCID: PMC5830704.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99.
Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. PMID: 22585735; PMCID: PMC3371730.
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PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 01; 303(1):L12-9.
Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. PMID: 22561460; PMCID: PMC3426434.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med. 2012 Mar 04; 18(4):547-54.
Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. PMID: 22388091; PMCID: PMC3321096.
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PubMed Mentions:
228 Fields:
Translation:
HumansAnimalsCells
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Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol. 2012 Mar 15; 188(6):2622-9.
Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH. PMID: 22327070; PMCID: PMC3294141.
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PubMed Mentions:
57 Fields:
Translation:
Animals
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Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force. Exp Cell Res. 2012 Apr 01; 318(6):716-22.
Giacomini MM, Travis MA, Kudo M, Sheppard D. PMID: 22309779; PMCID: PMC3294033.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb; 122(2):748-58.
Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. PMID: 22232213; PMCID: PMC3266785.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):58-66.
Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. PMID: 21980034; PMCID: PMC3262039.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol. 2011 Nov 01; 3(11):a005017.
Munger JS, Sheppard D. PMID: 21900405; PMCID: PMC3220354.
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PubMed Mentions:
188 Fields:
Translation:
HumansAnimalsCells
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Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma. J Immunol. 2011 Dec 01; 187(11):6094-107.
Tatler AL, John AE, Jolly L, Habgood A, Porte J, Brightling C, Knox AJ, Pang L, Sheppard D, Huang X, Jenkins G. PMID: 22025551; PMCID: PMC3242066.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. Int J Rheumatol. 2011; 2011:208219.
Katsumoto TR, Violette SM, Sheppard D. PMID: 22013449; PMCID: PMC3195527.
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PubMed Mentions:
20
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Recommendations for the classification of diseases as CFTR-related disorders. J Cyst Fibros. 2011 Jun; 10 Suppl 2:S86-102.
Bombieri C, Claustres M, De Boeck K, Derichs N, Dodge J, Girodon E, Sermet I, Schwarz M, Tzetis M, Wilschanski M, Bareil C, Bilton D, Castellani C, Cuppens H, Cutting GR, Drevínek P, Farrell P, Elborn JS, Jarvi K, Kerem B, Kerem E, Knowles M, Macek M, Munck A, Radojkovic D, Seia M, Sheppard DN, Southern KW, Stuhrmann M, Tullis E, Zielenski J, Pignatti PF, Ferec C. PMID: 21658649.
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PubMed Mentions:
120 Fields:
Translation:
Humans
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Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era. Proc Am Thorac Soc. 2011 May; 8(2):199-202.
Sheppard D. PMID: 21543802; PMCID: PMC3159072.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Short form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunit. Exp Cell Res. 2011 Jul 15; 317(12):1774-84.
Kon S, Atakilit A, Sheppard D. PMID: 21515257; PMCID: PMC3118859.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. J Biol Chem. 2011 Apr 01; 286(13):11170-8.
Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y. PMID: 21321126; PMCID: PMC3064171.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Mol Cell Biol. 2011 Feb; 31(4):766-82.
Spassov DS, Wong CH, Sergina N, Ahuja D, Fried M, Sheppard D, Moasser MM. PMID: 21189288; PMCID: PMC3028653.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. J Clin Invest. 2010 Dec; 120(12):4436-44.
Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D. PMID: 21099117; PMCID: PMC2993595.
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PubMed Mentions:
75 Fields:
Translation:
AnimalsCells
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Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest. 2009 Dec; 119(12):3713-22.
Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. PMID: 19884654; PMCID: PMC2786804.
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PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
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beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2010 Jul; 43(1):88-98.
Hogmalm A, Sheppard D, Lappalainen U, Bry K. PMID: 19717813; PMCID: PMC2911573.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009 Aug; 17(2):175-86.
Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T. PMID: 19686679; PMCID: PMC2747264.
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PubMed Mentions:
175 Fields:
Translation:
HumansAnimalsCells
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Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem. 2009 Jul 17; 284(29):19650-8.
Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. PMID: 19435888; PMCID: PMC2740590.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Blood. 2009 Jul 02; 114(1):49-59.
Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT, Sheppard D, Choong PF, Nilsson SK. PMID: 19417209.
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PubMed Mentions:
97 Fields:
Translation:
HumansAnimalsCells
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Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). Am J Pathol. 2009 Apr; 174(4):1264-79.
Xu MY, Porte J, Knox AJ, Weinreb PH, Maher TM, Violette SM, McAnulty RJ, Sheppard D, Jenkins G. PMID: 19147812; PMCID: PMC2671359.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol. 2009 Jan; 129(1):217-28.
Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L. PMID: 18633440; PMCID: PMC3681306.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A. 2008 May 20; 105(20):7188-93.
deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D. PMID: 18480266; PMCID: PMC2386075.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Dust mites' dirty dealings with dendritic cells. Nat Med. 2008 May; 14(5):487-8.
Sheppard D. PMID: 18463654.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Am J Pathol. 2008 Apr; 172(4):1127-40.
Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L. PMID: 18349127; PMCID: PMC2276431.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12.
Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. PMID: 18276918; PMCID: PMC2739091.
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PubMed Mentions:
131 Fields:
Translation:
HumansAnimalsCells
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An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med. 2008 Mar 15; 177(6):638-45.
Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES. PMID: 18096707; PMCID: PMC2267338.
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PubMed Mentions:
151 Fields:
Translation:
HumansAnimalsCells
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Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62.
Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. PMID: 17965775; PMCID: PMC2040320.
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PubMed Mentions:
121 Fields:
Translation:
HumansAnimalsCells
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Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med. 2008 Jan 01; 177(1):56-65.
Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, Simon KJ, Hahm K, Allaire NE, Rinaldi NJ, Goyal J, Feghali-Bostwick CA, Matteson EL, O'Hara C, Lafyatis R, Davis GS, Huang X, Sheppard D, Violette SM. PMID: 17916809.
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PubMed Mentions:
184 Fields:
Translation:
Animals
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Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 2007 Sep 20; 449(7160):361-5.
Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. PMID: 17694047; PMCID: PMC2670239.
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PubMed Mentions:
272 Fields:
Translation:
AnimalsCells
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Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9.
Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. PMID: 17641300; PMCID: PMC2219547.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12005-10.
Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC. PMID: 17620600; PMCID: PMC1924559.
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PubMed Mentions:
134 Fields:
Translation:
AnimalsCells
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Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51.
Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. PMID: 17468134; PMCID: PMC4212816.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem. 2007 May 18; 282(20):15187-96.
Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D. PMID: 17363377.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Roles of the innate immune system in mammary gland remodeling during involution. J Mammary Gland Biol Neoplasia. 2007 Mar; 12(1):37-45.
Atabai K, Sheppard D, Werb Z. PMID: 17286210; PMCID: PMC2574498.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Identification and molecular characterization of multiple phenotypes in integrin knockout mice. Methods Enzymol. 2007; 426:291-305.
Chen C, Sheppard D. PMID: 17697889.
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PubMed Mentions:
12 Fields:
Translation:
Animals
-
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol. 2007 Jan; 170(1):110-25.
Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, McCrann DJ, Allaire NE, Horan GS, Fogo A, Kalluri R, Shield CF, Sheppard D, Gardner HA, Violette SM. PMID: 17200187; PMCID: PMC1762706.
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PubMed Mentions:
98 Fields:
Translation:
HumansAnimalsCells
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Pulmonary emphysema: when more is less. Physiology (Bethesda). 2006 Dec; 21:396-403.
Morris DG, Sheppard D. PMID: 17119152.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Immunity. 2006 Dec; 25(6):895-906.
Chen C, Huang X, Atakilit A, Zhu QS, Corey SJ, Sheppard D. PMID: 17137800.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86.
Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. PMID: 17079779; PMCID: PMC1899321.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
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Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res. 2006 Oct; 21(10):1657-65.
Rao H, Lu G, Kajiya H, Garcia-Palacios V, Kurihara N, Anderson J, Patrene K, Sheppard D, Blair HC, Windle JJ, Choi SJ, Roodman GD. PMID: 16995821; PMCID: PMC1937336.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol. 2006 Sep; 26(18):6950-6.
Chen C, Huang X, Sheppard D. PMID: 16943435; PMCID: PMC1592855.
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PubMed Mentions:
28 Fields:
Translation:
Animals
-
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13180-5.
Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. PMID: 16924102; PMCID: PMC1551904.
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PubMed Mentions:
609 Fields:
Translation:
HumansAnimalsCells
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Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc. 2006 Jul; 3(5):413-7.
Sheppard D. PMID: 16799084; PMCID: PMC2658705.
View in:
PubMed Mentions:
146 Fields:
Translation:
HumansAnimals
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Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006 Jun; 116(6):1606-14.
Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. PMID: 16710477; PMCID: PMC1462943.
View in:
PubMed Mentions:
145 Fields:
Translation:
HumansAnimalsCells
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Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):252-9.
Neurohr C, Nishimura SL, Sheppard D. PMID: 16574941; PMCID: PMC2643260.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Population stratification confounds genetic association studies among Latinos. Hum Genet. 2006 Jan; 118(5):652-64.
Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard D, Shriver MD, Rodriguez-Cintron W, Risch N, Ziv E, Burchard EG, Genetics of Asthma in Latino Americans GALA Study. PMID: 16283388.
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PubMed Mentions:
115 Fields:
Translation:
Humans
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Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell. 2005 Dec; 16(12):5528-37.
Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. PMID: 16195353; PMCID: PMC1289399.
View in:
PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Integrin-mediated activation of latent transforming growth factor beta. Cancer Metastasis Rev. 2005 Sep; 24(3):395-402.
Sheppard D. PMID: 16258727.
View in:
PubMed Mentions:
82 Fields:
Translation:
HumansAnimalsCells
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Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol. 2005 Jul; 29(1):76-86.
Salari K, Choudhry S, Tang H, Naqvi M, Lind D, Avila PC, Coyle NE, Ung N, Nazario S, Casal J, Torres-Palacios A, Clark S, Phong A, Gomez I, Matallana H, Pérez-Stable EJ, Shriver MD, Kwok PY, Sheppard D, Rodriguez-Cintron W, Risch NJ, Burchard EG, Ziv E. PMID: 15918156.
View in:
PubMed Mentions:
92 Fields:
Translation:
Humans
-
Characterization of integrin beta6 and thrombospondin-1 double-null mice. J Cell Mol Med. 2005 Apr-Jun; 9(2):421-37.
Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J. PMID: 15963261; PMCID: PMC6740207.
View in:
PubMed Mentions:
29 Fields:
Translation:
Animals
-
ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7. Biochem J. 2005 Apr 01; 387(Pt 1):101-8.
Bridges LC, Sheppard D, Bowditch RD. PMID: 15504110; PMCID: PMC1134937.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem. 2005 May 13; 280(19):18579-89.
Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF. PMID: 15755725.
View in:
PubMed Mentions:
94 Fields:
Translation:
HumansAnimalsCells
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Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005 Feb; 115(2):339-47.
Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM. PMID: 15668738; PMCID: PMC544606.
View in:
PubMed Mentions:
159 Fields:
Translation:
HumansAnimalsCells
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Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. J Exp Med. 2004 Dec 20; 200(12):1539-45.
Nandrot EF, Kim Y, Brodie SE, Huang X, Sheppard D, Finnemann SC. PMID: 15596525; PMCID: PMC2211990.
View in:
PubMed Mentions:
165 Fields:
Translation:
AnimalsCells
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The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. J Biol Chem. 2005 Feb 11; 280(6):4544-52.
Vlahakis NE, Young BA, Atakilit A, Sheppard D. PMID: 15590642; PMCID: PMC1368959.
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PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):563-70.
Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, Lilly C, Matallana H, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Drazen JM, Rodriguez-Cintron W, Silverman EK, Burchard EG. PMID: 15557128.
View in:
PubMed Mentions:
78 Fields:
Translation:
Humans
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Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res. 2005 Jan; 20(1):58-66.
Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL. PMID: 15619670.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Fishing in the bloodstream: insights into the mechanisms of pulmonary hypertension? Am J Respir Crit Care Med. 2004 Oct 15; 170(8):827-8.
Sheppard D. PMID: 15475403.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol. 2004 Oct 11; 167(1):161-70.
Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D. PMID: 15479742; PMCID: PMC2172529.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Roles of alphav integrins in vascular biology and pulmonary pathology. Curr Opin Cell Biol. 2004 Oct; 16(5):552-7.
Sheppard D. PMID: 15363806.
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PubMed Mentions:
36 Fields:
Translation:
Animals
-
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. J Virol. 2004 Jul; 78(13):6967-73.
Williams CH, Kajander T, Hyypiä T, Jackson T, Sheppard D, Stanway G. PMID: 15194773; PMCID: PMC421648.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins. Biochemistry. 2004 Feb 17; 43(6):1639-47.
Bazan-Socha S, Kisiel DG, Young B, Theakston RD, Calvete JJ, Sheppard D, Marcinkiewicz C. PMID: 14769041.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes. J Biol Chem. 2004 Apr 23; 279(17):17875-87.
Weinreb PH, Simon KJ, Rayhorn P, Yang WJ, Leone DR, Dolinski BM, Pearse BR, Yokota Y, Kawakatsu H, Atakilit A, Sheppard D, Violette SM. PMID: 14960589.
View in:
PubMed Mentions:
83 Fields:
Translation:
HumansAnimalsCells
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Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004 Feb 01; 169(3):386-92.
Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK, Genetics of Asthma in Latino Americans (GALA) Study. PMID: 14617512.
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PubMed Mentions:
83 Fields:
Translation:
Humans
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Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Exp Cell Res. 2003 Oct 15; 290(1):68-81.
Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM. PMID: 14516789.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol. 2003 Oct; 163(4):1261-73.
Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. PMID: 14507636; PMCID: PMC1868298.
View in:
PubMed Mentions:
100 Fields:
Translation:
Animals
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Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. Am J Respir Cell Mol Biol. 2004 Apr; 30(4):540-7.
Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM. PMID: 12972402.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1312-6.
Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, Chapela R, Ford JG, Rodriguez-Cintron W, Silverman EK, Sheppard D, Kwok PY, González Burchard E. PMID: 12958057.
View in:
PubMed Mentions:
42 Fields:
Translation:
Humans
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Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50.
Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. PMID: 12930837.
View in:
PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Functions of pulmonary epithelial integrins: from development to disease. Physiol Rev. 2003 Jul; 83(3):673-86.
Sheppard D. PMID: 12843406.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003 Mar 20; 348(12):1170-5.
Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N. PMID: 12646676.
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PubMed Mentions:
295 Fields:
Translation:
Humans
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Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature. 2003 Mar 13; 422(6928):169-73.
Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. PMID: 12634787.
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PubMed Mentions:
184 Fields:
Translation:
HumansAnimalsCells
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Endothelial integrins and angiogenesis: not so simple anymore. J Clin Invest. 2002 Oct; 110(7):913-4.
Sheppard D. PMID: 12370267; PMCID: PMC151161.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1. Am J Pathol. 2002 Sep; 161(3):771-9.
Knight PA, Wright SH, Brown JK, Huang X, Sheppard D, Miller HR. PMID: 12213704; PMCID: PMC1867270.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2002 Jul 15; 166(2):236-46.
Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA. PMID: 12119236.
View in:
PubMed Mentions:
66 Fields:
Translation:
Humans
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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002 Aug; 8(8):885-9.
Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. PMID: 12091879.
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PubMed Mentions:
351 Fields:
Translation:
HumansAnimalsCells
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Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6292-7.
Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA. PMID: 11983918; PMCID: PMC122942.
View in:
PubMed Mentions:
247 Fields:
Translation:
HumansAnimalsCells
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The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002 Apr 29; 157(3):493-507.
Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL. PMID: 11970960; PMCID: PMC2173277.
View in:
PubMed Mentions:
353 Fields:
Translation:
HumansAnimalsCells
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Killed by leukocytes that don't know when to leave. Nat Immunol. 2002 Apr; 3(4):337-8.
Sheppard D. PMID: 11919573.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002 Apr 01; 157(1):149-60.
Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA. PMID: 11927607; PMCID: PMC2173263.
View in:
PubMed Mentions:
138 Fields:
Translation:
HumansAnimalsCells
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Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem. 2002 May 17; 277(20):17804-10.
Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y. PMID: 11882657.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans. Chest. 2002 Mar; 121(3 Suppl):31S-32S.
Kaminski N, Zuo F, Cojocaro G, Yakhini Z, Ben-Dor A, Morris D, Sheppard D, Pardo A, Selman M, Heller RA. PMID: 11893671.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema. Chest. 2002 Mar; 121(3 Suppl):21S-25S.
Sheppard D. PMID: 11893658.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J Biol Chem. 2002 Apr 26; 277(17):14467-74.
Liao YF, Gotwals PJ, Koteliansky VE, Sheppard D, Van De Water L. PMID: 11839764.
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PubMed Mentions:
101 Fields:
Translation:
HumansCells
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Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus. J Virol. 2002 Feb; 76(3):935-41.
Jackson T, Mould AP, Sheppard D, King AM. PMID: 11773368; PMCID: PMC135819.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med. 2002 Jan; 8(1):27-34.
Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. PMID: 11786903.
View in:
PubMed Mentions:
237 Fields:
Translation:
Animals
-
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001 Nov; 49(11):1341-50.
Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC. PMID: 11668187.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):474-85.
Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. PMID: 11694453.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansCells
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The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner. Mol Biol Cell. 2001 Oct; 12(10):3214-25.
Young BA, Taooka Y, Liu S, Askins KJ, Yokosaki Y, Thomas SM, Sheppard D. PMID: 11598204; PMCID: PMC60168.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells. J Invest Dermatol. 2001 Jul; 117(1):67-73.
Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF. PMID: 11442751.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis. Chest. 2001 Jul; 120(1 Suppl):49S-53S.
Sheppard D. PMID: 11451914.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Pulmonary fibrosis: a cellular overreaction or a failure of communication? J Clin Invest. 2001 Jun; 107(12):1501-2.
Sheppard D. PMID: 11413155; PMCID: PMC200201.
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PubMed Mentions:
19 Fields:
Translation:
Animals
-
TGF-beta is a critical mediator of acute lung injury. J Clin Invest. 2001 Jun; 107(12):1537-44.
Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D. PMID: 11413161; PMCID: PMC200192.
View in:
PubMed Mentions:
199 Fields:
Translation:
AnimalsCells
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Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus. J Virol. 2001 May; 75(9):4158-64.
Miller LC, Blakemore W, Sheppard D, Atakilit A, King AM, Jackson T. PMID: 11287565; PMCID: PMC114161.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium. J Histochem Cytochem. 2001 Jan; 49(1):41-8.
Miller LA, Barnett NL, Sheppard D, Hyde DM. PMID: 11118477.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem. 2000 Nov 10; 275(45):34922-30.
Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y. PMID: 10944520.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin. J Biol Chem. 2000 Oct 13; 275(41):31930-7.
Marcinkiewicz C, Taooka Y, Yokosaki Y, Calvete JJ, Marcinkiewicz MM, Lobb RR, Niewiarowski S, Sheppard D. PMID: 10926928.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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A primary culture model of differentiated murine tracheal epithelium. Am J Physiol Lung Cell Mol Physiol. 2000 Oct; 279(4):L766-78.
Davidson DJ, Kilanowski FM, Randell SH, Sheppard DN, Dorin JR. PMID: 11000138.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Functional genomics and expression profiling: be there or be square. Am J Respir Cell Mol Biol. 2000 Sep; 23(3):265-9.
Albelda SM, Sheppard D. PMID: 10970813.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1. J Biol Chem. 2000 Aug 04; 275(31):23589-95.
Takahashi H, Isobe T, Horibe S, Takagi J, Yokosaki Y, Sheppard D, Saito Y. PMID: 10816592.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol. 2000 Jul; 20(14):5208-15.
Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D. PMID: 10866676; PMCID: PMC85969.
View in:
PubMed Mentions:
114 Fields:
Translation:
Animals
-
In vivo functions of integrins: lessons from null mutations in mice. Matrix Biol. 2000 Jul; 19(3):203-9.
Sheppard D. PMID: 10936445.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimals
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The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus. J Virol. 2000 Jun; 74(11):4949-56.
Jackson T, Sheppard D, Denyer M, Blakemore W, King AM. PMID: 10799568; PMCID: PMC110846.
View in:
PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair. Trends Cardiovasc Med. 2000 May; 10(4):155-9.
Yokasaki Y, Sheppard D. PMID: 11239795.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line. J Physiol. 2000 Apr 15; 524 Pt 2:317-30.
Lansdell KA, Cai Z, Kidd JF, Sheppard DN. PMID: 10766914; PMCID: PMC2269882.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1778-83.
Kaminski N, Allard JD, Pittet JF, Zuo F, Griffiths MJ, Morris D, Huang X, Sheppard D, Heller RA. PMID: 10677534; PMCID: PMC26512.
View in:
PubMed Mentions:
136 Fields:
Translation:
AnimalsCells
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Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Mol Cell Biol. 2000 Feb; 20(3):755-9.
Huang X, Griffiths M, Wu J, Farese RV, Sheppard D. PMID: 10629031; PMCID: PMC85191.
View in:
PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem. 1999 Dec 17; 274(51):36328-34.
Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D. PMID: 10593924.
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PubMed Mentions:
114 Fields:
Translation:
HumansAnimalsCells
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Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration. J Cell Sci. 1999 Dec; 112 ( Pt 23):4271-9.
Milner R, Huang X, Wu J, Nishimura S, Pytela R, Sheppard D, ffrench-Constant C. PMID: 10564645.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA. Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3108-15.
Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, Brown DJ. PMID: 10586931.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Inhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents. Br J Pharmacol. 1999 Sep; 128(1):108-18.
Cai Z, Lansdell KA, Sheppard DN. PMID: 10498841; PMCID: PMC1571594.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Airway remodeling and repair. Am J Respir Crit Care Med. 1999 Sep; 160(3):1035-42.
Busse W, Elias J, Sheppard D, Banks-Schlegel S. PMID: 10471638.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimals
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Fibronectin and alpha5beta1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium. Eur Respir J. 1999 Jun; 13(6):1301-9.
Roger P, Puchelle E, Bajolet-Laudinat O, Tournier JM, Debordeaux C, Plotkowski MC, Cohen JH, Sheppard D, de Bentzmann S. PMID: 10445605.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
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The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1. J Cell Biol. 1999 Apr 19; 145(2):413-20.
Taooka Y, Chen J, Yednock T, Sheppard D. PMID: 10209034; PMCID: PMC2133104.
View in:
PubMed Mentions:
77 Fields:
Translation:
HumansAnimalsCells
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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999 Feb 05; 96(3):319-28.
Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. PMID: 10025398.
View in:
PubMed Mentions:
844 Fields:
Translation:
HumansAnimalsCells
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Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998 Dec 18; 282(5397):2261-3.
Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. PMID: 9856950; PMCID: PMC3897229.
View in:
PubMed Mentions:
567 Fields:
Translation:
HumansAnimalsCells
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Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation. J Cell Biochem. 1998 Dec 15; 71(4):536-45.
Desloges N, Basora N, Perreault N, Bouatrouss Y, Sheppard D, Beaulieu JF. PMID: 9827699.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice. Am J Respir Cell Mol Biol. 1998 Oct; 19(4):636-42.
Huang X, Wu J, Zhu W, Pytela R, Sheppard D. PMID: 9761761.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Airway epithelial integrins: why so many? Am J Respir Cell Mol Biol. 1998 Sep; 19(3):349-51.
Sheppard D. PMID: 9730861.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. J Cell Sci. 1998 Aug; 111 ( Pt 15):2189-95.
Huang X, Wu J, Spong S, Sheppard D. PMID: 9664040.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins. FEBS Lett. 1998 Jun 16; 429(3):269-73.
Schneider H, Harbottle RP, Yokosaki Y, Kunde J, Sheppard D, Coutelle C. PMID: 9662430.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C. J Biol Chem. 1998 May 08; 273(19):11423-8.
Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, Shigeto N, Chen J, Sheppard D. PMID: 9565552.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCells
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Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol Med. 1998 May; 4(5):344-55.
Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. PMID: 9642684; PMCID: PMC2230383.
View in:
PubMed Mentions:
87 Fields:
Translation:
AnimalsCells
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Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells. J Physiol. 1998 Apr 15; 508 ( Pt 2):379-92.
Lansdell KA, Delaney SJ, Lunn DP, Thomson SA, Sheppard DN, Wainwright BJ. PMID: 9508803; PMCID: PMC2230885.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Expression of the alpha9beta1 integrin in human colonic epithelial cells: resurgence of the fetal phenotype in a subset of colon cancers and adenocarcinoma cell lines. Int J Cancer. 1998 Mar 02; 75(5):738-43.
Basora N, Desloges N, Chang Q, Bouatrouss Y, Gosselin J, Poisson J, Sheppard D, Beaulieu JF. PMID: 9495242.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Epidermal integrin expression is upregulated rapidly in human fetal wound repair. J Pediatr Surg. 1998 Feb; 33(2):312-6.
Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS. PMID: 9498408.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells. Virology. 1997 Dec 08; 239(1):71-7.
Agrez MV, Shafren DR, Gu X, Cox K, Sheppard D, Barry RD. PMID: 9426447.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C. Int J Cancer. 1997 Jul 17; 72(2):369-76.
Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R. PMID: 9219848.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin. J Biol Chem. 1996 Nov 08; 271(45):28485-91.
Smith LL, Cheung HK, Ling LE, Chen J, Sheppard D, Pytela R, Giachelli CM. PMID: 8910476.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium. Am J Physiol. 1996 Nov; 271(5 Pt 1):L726-33.
Hérard AL, Pierrot D, Hinnrasky J, Kaplan H, Sheppard D, Puchelle E, Zahm JM. PMID: 8944715.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Distinct structural requirements for interaction of the integrins alpha 5 beta 1, alpha v beta 5, and alpha v beta 6 with the central cell binding domain in fibronectin. Cell Adhes Commun. 1996 Nov; 4(4-5):237-50.
Chen J, Maeda T, Sekiguchi K, Sheppard D. PMID: 9117344.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Differential regulation of airway epithelial integrins by growth factors. Am J Respir Cell Mol Biol. 1996 Nov; 15(5):664-72.
Wang A, Yokosaki Y, Ferrando R, Balmes J, Sheppard D. PMID: 8918373.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture. J Biol Chem. 1996 Oct 18; 271(42):25976-80.
Dixit RB, Chen A, Chen J, Sheppard D. PMID: 8824234.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains. J Biol Chem. 1996 Sep 27; 271(39):24144-50.
Yokosaki Y, Monis H, Chen J, Sheppard D. PMID: 8798654.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Epithelial integrins. Bioessays. 1996 Aug; 18(8):655-60.
Sheppard D. PMID: 8760339.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May; 133(4):921-8.
Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D. PMID: 8666675; PMCID: PMC2120829.
View in:
PubMed Mentions:
119 Fields:
Translation:
HumansAnimalsCells
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Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer. Br J Cancer. 1996 Apr; 73(7):887-92.
Agrez MV, Bates RC, Mitchell D, Wilson N, Ferguson N, Anseline P, Sheppard D. PMID: 8611401; PMCID: PMC2074269.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Expression of the integrin subunit alpha 9 in the murine embryo. Dev Dyn. 1995 Dec; 204(4):421-31.
Wang A, Patrone L, McDonald JA, Sheppard D. PMID: 8601035.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells. Exp Cell Res. 1995 Dec; 221(2):385-94.
Kumar NM, Sigurdson SL, Sheppard D, Lwebuga-Mukasa JS. PMID: 7493638.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5. J Clin Invest. 1995 Oct; 96(4):1987-2001.
Boylan AM, Sanan DA, Sheppard D, Broaddus VC. PMID: 7560092; PMCID: PMC185837.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J Biol Chem. 1995 Sep 29; 270(39):23196-202.
Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R. PMID: 7559467.
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PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts. Am J Respir Cell Mol Biol. 1995 Aug; 13(2):245-51.
Huang XZ, Chen A, Agrez M, Sheppard D. PMID: 7626292.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways. Am J Respir Cell Mol Biol. 1995 May; 12(5):547-56.
Weinacker A, Ferrando R, Elliott M, Hogg J, Balmes J, Sheppard D. PMID: 7537970.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Localized distribution of alpha 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation. J Histochem Cytochem. 1995 Apr; 43(4):353-62.
Stepp MA, Zhu L, Sheppard D, Cranfill RL. PMID: 7534781.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. J Cell Sci. 1995 Feb; 108 ( Pt 2):537-44.
Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R. PMID: 7768999.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Localization of the alpha v subfamily of integrins and their putative ligands in synovial lining cell layer. J Rheumatol. 1995 Jan; 22(1):16-23.
Nikkari L, Haapasalmi K, Aho H, Torvinen A, Sheppard D, Larjava H, Heino J. PMID: 7535359.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Staphylococcus aureus stimulates neutrophil recruitment by stimulating interleukin-8 production in dog trachea. Am J Physiol. 1995 Jan; 268(1 Pt 1):L85-94.
Massion PP, Hébert CA, Leong S, Chan B, Inoue H, Grattan K, Sheppard D, Nadel JA. PMID: 7840233.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. J Biol Chem. 1994 Nov 18; 269(46):28708-15.
Nishimura SL, Sheppard D, Pytela R. PMID: 7525578.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansCells
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The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. J Biol Chem. 1994 Oct 28; 269(43):26691-6.
Yokosaki Y, Palmer EL, Prieto AL, Crossin KL, Bourdon MA, Pytela R, Sheppard D. PMID: 7523411.
View in:
PubMed Mentions:
64 Fields:
Translation:
HumansAnimalsCells
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The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain. J Cell Biol. 1994 Oct; 127(2):547-56.
Agrez M, Chen A, Cone RI, Pytela R, Sheppard D. PMID: 7929593; PMCID: PMC2120218.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain. J Biol Chem. 1994 Jul 15; 269(28):18311-4.
Lukashev ME, Sheppard D, Pytela R. PMID: 7518428.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Dominant negative mutants: tools for the study of protein function in vitro and in vivo. Am J Respir Cell Mol Biol. 1994 Jul; 11(1):1-6.
Sheppard D. PMID: 8018332.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts. Cell Adhes Commun. 1994 Jun; 2(2):101-13.
Cone RI, Weinacker A, Chen A, Sheppard D. PMID: 8081887.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994 Mar 04; 269(9):6940-8.
Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D. PMID: 8120056.
View in:
PubMed Mentions:
77 Fields:
Translation:
HumansAnimalsCells
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Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules. Methods Enzymol. 1994; 245:420-51.
Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D. PMID: 7760745.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Identification and characterization of novel airway epithelial integrins. Am Rev Respir Dis. 1993 Dec; 148(6 Pt 2):S38-42.
Sheppard D. PMID: 8256923.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
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Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. J Cell Biol. 1993 Dec; 123(5):1289-97.
Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D. PMID: 8245132; PMCID: PMC2119880.
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PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. J Histochem Cytochem. 1993 Oct; 41(10):1521-7.
Breuss JM, Gillett N, Lu L, Sheppard D, Pytela R. PMID: 8245410.
View in:
PubMed Mentions:
94 Fields:
Translation:
Animals
-
Occupational asthma in a pesticides manufacturing worker. Chest. 1993 Jan; 103(1):295-6.
Royce S, Wald P, Sheppard D, Balmes J. PMID: 8417906.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells. J Biol Chem. 1992 Aug 25; 267(24):17409-14.
Sheppard D, Cohen DS, Wang A, Busk M. PMID: 1512272.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. J Biol Chem. 1992 Mar 25; 267(9):5790-6.
Busk M, Pytela R, Sheppard D. PMID: 1532572.
View in:
PubMed Mentions:
87 Fields:
Translation:
HumansCells
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Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction. Chest. 1992 Mar; 101(3 Suppl):49S.
Sheppard D, Erle D, Busk M, Pytela R. PMID: 1541204.
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PubMed Mentions: Fields:
Translation:
Animals
-
Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin. Br J Ind Med. 1991 Sep; 48(9):629-35.
Gordon T, Balmes J, Fine J, Sheppard D. PMID: 1911406; PMCID: PMC1035436.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor. J Biol Chem. 1991 Aug 25; 266(24):15598-601.
Wang A, Cohen DS, Palmer E, Sheppard D. PMID: 1874718.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):170-7.
Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R. PMID: 1892648.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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The response of guinea pig airway epithelial cells and alveolar macrophages to environmental stress. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):133-43.
Cohen DS, Palmer E, Welch WJ, Sheppard D. PMID: 1892643.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. J Biol Chem. 1991 Jun 15; 266(17):11009-16.
Erle DJ, Rüegg C, Sheppard D, Pytela R. PMID: 2040616.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Lack of bronchoconstrictor response to sulfuric acid aerosols and fogs. Am Rev Respir Dis. 1991 Apr; 143(4 Pt 1):744-50.
Aris R, Christian D, Sheppard D, Balmes JR. PMID: 2008986.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
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The effects of sequential exposure to acidic fog and ozone on pulmonary function in exercising subjects. Am Rev Respir Dis. 1991 Jan; 143(1):85-91.
Aris R, Christian D, Sheppard D, Balmes JR. PMID: 1846067.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
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Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. J Biol Chem. 1990 Jul 15; 265(20):11502-7.
Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R. PMID: 2365683.
View in:
PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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Acid fog-induced bronchoconstriction. The role of hydroxymethanesulfonic acid. Am Rev Respir Dis. 1990 Mar; 141(3):546-51.
Aris R, Christian D, Sheppard D, Balmes JR. PMID: 2155554.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansPHPublic Health
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Potential bronchoconstrictor stimuli in acid fog. Environ Health Perspect. 1989 Feb; 79:163-6.
Balmes JR, Fine JM, Gordon T, Sheppard D. PMID: 2539989; PMCID: PMC1567583.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansPHPublic Health
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Epithelium removal alters responsiveness of guinea pig trachea to substance P. J Appl Physiol (1985). 1989 Jan; 66(1):232-7.
Fine JM, Gordon T, Sheppard D. PMID: 2465289.
View in:
PubMed Mentions:
14 Fields:
Translation:
Animals
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Sulfur dioxide and asthma--a double-edged sword? J Allergy Clin Immunol. 1988 Dec; 82(6):961-4.
Sheppard D. PMID: 3060513.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. Am Rev Respir Dis. 1988 Sep; 138(3):547-51.
Sheppard D, Scypinski L. PMID: 2462379.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
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Acidity potentiates bronchoconstriction induced by hypoosmolar aerosols. Am Rev Respir Dis. 1988 Jul; 138(1):35-9.
Balmes JR, Fine JM, Christian D, Gordon T, Sheppard D. PMID: 2849338.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
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Arachidonic acid metabolites do not mediate toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. Prostaglandins. 1988 May; 35(5):699-706.
Gordon T, Thompson JE, Sheppard D. PMID: 2840688.
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PubMed Mentions: Fields:
Translation:
Animals
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Tumor necrosis factor inhibits a polymorphonuclear leukocyte-dependent airway edema in guinea pigs. J Appl Physiol (1985). 1988 Apr; 64(4):1688-92.
Gordon T, Sheppard D. PMID: 2837454.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase. J Clin Invest. 1988 Apr; 81(4):1111-5.
Sheppard D, Thompson JE, Scypinski L, Dusser D, Nadel JA, Borson DB. PMID: 2450892; PMCID: PMC329638.
View in:
PubMed Mentions:
13 Fields:
Translation:
Animals
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Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction. Chest. 1988 Mar; 93(3):476-81.
Turner JR, Corkery KJ, Eckman D, Gelb AM, Lipavsky A, Sheppard D. PMID: 3342656.
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Phosphoramidon potentiates the increase in lung resistance mediated by tachykinins in guinea pigs. Am Rev Respir Dis. 1988 Feb; 137(2):337-40.
Thompson JE, Sheppard D. PMID: 2449105.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Karyotypic analysis of the human monoblastic cell line U937. Cancer Genet Cytogenet. 1988 Feb; 30(2):277-84.
Shipley JM, Sheppard DM, Sheer D. PMID: 3422581.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Mechanisms of acute increases in airway responsiveness caused by environmental chemicals. J Allergy Clin Immunol. 1988 Jan; 81(1):128-32.
Sheppard D. PMID: 2828449.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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The roles of pH and ionic species in sulfur dioxide- and sulfite-induced bronchoconstriction. Am Rev Respir Dis. 1987 Nov; 136(5):1122-6.
Fine JM, Gordon T, Sheppard D. PMID: 3674574.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
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Symptomatic bronchoconstriction after short-term inhalation of sulfur dioxide. Am Rev Respir Dis. 1987 Nov; 136(5):1117-21.
Balmes JR, Fine JM, Sheppard D. PMID: 3674573.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
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What does exercise have to do with "exercise-induced" asthma? Am Rev Respir Dis. 1987 Sep; 136(3):547-9.
Sheppard D. PMID: 3631726.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
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Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs. Am Rev Respir Dis. 1987 Jul; 136(1):43-9.
Thompson JE, Scypinski LA, Gordon T, Sheppard D. PMID: 2440357.
View in:
PubMed Mentions:
15 Fields:
Translation:
Animals
-
Apparent effect of catalase on airway edema in guinea pigs. Role of endotoxin contamination. Am Rev Respir Dis. 1987 Apr; 135(4):854-9.
Gordon T, Milligan SA, Levin J, Thompson JE, Fine JM, Sheppard D. PMID: 3032030.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCellsPHPublic Health
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The role of titratable acidity in acid aerosol-induced bronchoconstriction. Am Rev Respir Dis. 1987 Apr; 135(4):826-30.
Fine JM, Gordon T, Thompson JE, Sheppard D. PMID: 3551704.
View in:
PubMed Mentions:
12 Fields:
Translation:
Humans
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Physiology of the parasympathetic nervous system of the lung. Postgrad Med J. 1987; 63 Suppl 1:21-7.
Sheppard D. PMID: 3321011.
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PubMed Mentions: Fields:
Translation:
Humans
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Hydroxyurea inhibits airway hyperresponsiveness in guinea pigs by a granulocyte-independent mechanism. Am Rev Respir Dis. 1986 Dec; 134(6):1213-8.
Thompson JE, Scypinski LA, Gordon T, Sheppard D. PMID: 3024538.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Mechanisms of bronchoconstriction from nonimmunologic environmental stimuli. Chest. 1986 Oct; 90(4):584-7.
Sheppard D. PMID: 3757569.
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PubMed Mentions: Fields:
Translation:
Humans
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Interaction of cromolyn and a muscarinic antagonist in inhibiting bronchial reactivity to sulfur dioxide and to eucapnic hyperpnea alone. Am Rev Respir Dis. 1986 Jun; 133(6):1154-8.
Myers DJ, Bigby BG, Calvayrac P, Sheppard D, Boushey HA. PMID: 2940953.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCTClinical Trials
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Granulocyte-mediated airway edema in guinea pigs. J Appl Physiol (1985). 1986 Apr; 60(4):1213-20.
Sheppard D, Scypinski L, Horn J, Gordon T, Thompson JE. PMID: 3009387.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Am Rev Respir Dis. 1986 Apr; 133(4):515-8.
Bigby TD, Margolskee D, Curtis JL, Michael PF, Sheppard D, Hadley WK, Hopewell PC. PMID: 3485945.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimals
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Effects of esmolol on airway function in patients with asthma. J Clin Pharmacol. 1986 Mar; 26(3):169-74.
Sheppard D, DiStefano S, Byrd RC, Eschenbacher WL, Bell V, Steck J, Laddu A. PMID: 2870080.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCTClinical Trials
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Acute effects of routine firefighting on lung function. Am J Ind Med. 1986; 9(4):333-40.
Sheppard D, Distefano S, Morse L, Becker C. PMID: 3518426.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
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Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs. Am Rev Respir Dis. 1985 Nov; 132(5):1106-12.
Gordon T, Sheppard D, McDonald DM, Distefano S, Scypinski L. PMID: 2998244.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Effect of eucapnic hypoxia on bronchomotor tone and on the bronchomotor response to dry air in asthmatic subjects. Am Rev Respir Dis. 1985 Sep; 132(3):690-3.
Tam EK, Geffroy BA, Myers DJ, Seltzer J, Sheppard D, Boushey HA. PMID: 3929659.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCTClinical Trials
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Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma. Am Rev Respir Dis. 1985 Aug; 132(2):283-6.
Siegel D, Sheppard D, Gelb A, Weinberg PF. PMID: 2862819.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCTClinical Trials
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Respiratory heat loss is not the sole stimulus for bronchoconstriction induced by isocapnic hyperpnea with dry air. Am Rev Respir Dis. 1985 Jun; 131(6):894-901.
Eschenbacher WL, Sheppard D. PMID: 3923883.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
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Pharmacotherapy of asthma. West J Med. 1985 May; 142(5):700-2.
Sheppard D. PMID: 2861694; PMCID: PMC1306164.
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PubMed Mentions: Fields:
Translation:
Humans
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Effect of 0.25 ppm sulfur dioxide on airway resistance in freely breathing, heavily exercising, asthmatic subjects. Am Rev Respir Dis. 1985 Apr; 131(4):659-61.
Bethel RA, Sheppard D, Geffroy B, Tam E, Nadel JA, Boushey HA. PMID: 3994163.
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PubMed Mentions:
1 Fields:
Translation:
HumansCTClinical Trials
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Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma. Environ Res. 1984 Oct; 35(1):133-9.
Sheppard D, Eschenbacher WL, Epstein J. PMID: 6489284.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Morphine sulfate inhibits bronchoconstriction in subjects with mild asthma whose responses are inhibited by atropine. Am Rev Respir Dis. 1984 Sep; 130(3):363-7.
Eschenbacher WL, Bethel RA, Boushey HA, Sheppard D. PMID: 6476586.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCTClinical Trials
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Interaction of sulfur dioxide and dry cold air in causing bronchoconstriction in asthmatic subjects. J Appl Physiol Respir Environ Exerc Physiol. 1984 Aug; 57(2):419-23.
Bethel RA, Sheppard D, Epstein J, Tam E, Nadel JA, Boushey HA. PMID: 6469811.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCTClinical Trials
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Magnitude of the interaction between the bronchomotor effects of sulfur dioxide and those of dry (cold) air. Am Rev Respir Dis. 1984 Jul; 130(1):52-5.
Sheppard D, Eschenbacher WL, Boushey HA, Bethel RA. PMID: 6742611.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
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Respiratory water loss as a stimulus to exercise-induced bronchoconstriction. J Allergy Clin Immunol. 1984 May; 73(5 Pt 2):640-2.
Sheppard D, Eschenbacher WL. PMID: 6715729.
View in:
PubMed Mentions:
9 Fields:
Translation:
Humans
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Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis. 1984 Feb; 129(2):211-5.
Eschenbacher WL, Boushey HA, Sheppard D. PMID: 6696320.
View in:
PubMed Mentions:
50 Fields:
Translation:
Humans
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Variable inhibition of histamine-induced bronchoconstriction by atropine in subjects with asthma. J Allergy Clin Immunol. 1984 Jan; 73(1 Pt 1):82-7.
Sheppard D, Epstein J, Skoogh BE, Bethel RA, Nadel JA, Boushey HA. PMID: 6363488.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCTClinical Trials
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Sulfur dioxide-induced bronchoconstriction in freely breathing, exercising, asthmatic subjects. Am Rev Respir Dis. 1983 Dec; 128(6):987-90.
Bethel RA, Epstein J, Sheppard D, Nadel JA, Boushey HA. PMID: 6650990.
View in:
PubMed Mentions:
8 Fields:
Translation:
Humans
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Antihistaminic versus anticholinergic effects of atropine on canine trachealis muscle. Am Rev Respir Dis. 1983 Oct; 128(4):603-6.
Skoogh BE, Nadel JA, Fabbri LM, Sheppard D, Holtzman MJ. PMID: 6137986.
View in:
PubMed Mentions: Fields:
Translation:
Animals
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Purification of uroporphyrinogen decarboxylase from human erythrocytes. Immunochemical evidence for a single protein with decarboxylase activity in human erythrocytes and liver. Biochem J. 1983 Oct 01; 215(1):45-55.
Elder GH, Tovey JA, Sheppard DM. PMID: 6626181; PMCID: PMC1152362.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1983 Oct; 128(4):592-6.
Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA. PMID: 6354021.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCTClinical Trials
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Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis. 1983 Jun; 127(6):691-4.
Sheppard D, Rizk NW, Boushey HA, Bethel RA. PMID: 6407371.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Chest pain and hypoxemia from inhalation of a trichloroethane aerosol product. J Toxicol Clin Toxicol. 1983 Jun; 20(4):333-41.
Woo OF, Healey KM, Sheppard D, Tong TG. PMID: 6689182.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma. Environ Res. 1983 Apr; 30(2):412-9.
Sheppard D, Epstein J, Bethel RA, Nadel JA, Boushey HA. PMID: 6832125.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Effect of route of atropine delivery on bronchospasm from cold air and methacholine. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):130-3.
Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. PMID: 6337982.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCTClinical Trials
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Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):134-9.
Holtzman MJ, McNamara MP, Sheppard D, Fabbri LM, Hahn HL, Graf PD, Nadel JA. PMID: 6826397.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Occupational asthma. West J Med. 1982 Dec; 137(6):480-5.
Sheppard D. PMID: 7164429; PMCID: PMC1274218.
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PubMed Mentions: Fields:
Translation:
Humans
-
Effect of the oronasal breathing route on sulfur dioxide-induced bronchoconstriction in exercising asthmatic subjects. Am Rev Respir Dis. 1982 Jun; 125(6):627-31.
Kirkpatrick MB, Sheppard D, Nadel JA, Boushey HA. PMID: 7091868.
View in:
PubMed Mentions:
10 Fields:
Translation:
Humans
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Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects. Am Rev Respir Dis. 1981 Sep; 124(3):257-9.
Sheppard D, Nadel JA, Boushey HA. PMID: 6792956.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCTClinical Trials
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Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1981 May; 123(5):486-91.
Sheppard D, Saisho A, Nadel JA, Boushey HA. PMID: 7235370.
View in:
PubMed Mentions:
25 Fields:
Translation:
Humans
-
Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Am Rev Respir Dis. 1980 Dec; 122(6):873-8.
Sheppard D, Wong WS, Uehara CF, Nadel JA, Boushey HA. PMID: 7458061.
View in:
PubMed Mentions:
49 Fields:
Translation:
Humans