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Mark Le Gros, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnatomy
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-514-0423
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    Collapse Research 
    Collapse Research Activities and Funding
    Resource for X-ray Tomography of Whole Cells
    NIH/NCRR P41RR019664May 6, 2004 - Apr 30, 2013
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Le Gros M, Clowney EJ, Magklara A, Yen A, Markenscoff-Papadimitriou E, Colquitt B, Myllys M, Kellis M, Lomvardas S, Larabell CA. Soft X-Ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis In Vivo. Cell Rep. 2016 11 15; 17(8):2125-2136. PMID: 27851973.
      View in: PubMed
    2. Ekman AA, Chen JH, Guo J, McDermott G, Le Gros M, Larabell CA. Mesoscale imaging with cryo-light and X-rays: Larger than molecular machines, smaller than a cell. Biol Cell. 2017 Jan; 109(1):24-38. PMID: 27690365.
      View in: PubMed
    3. Tjong H, Li W, Kalhor R, Dai C, Hao S, Gong K, Zhou Y, Li H, Zhou XJ, Le Gros M, Larabell CA, Chen L, Alber F. Population-based 3D genome structure analysis reveals driving forces in spatial genome organization. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):E1663-72. PMID: 26951677; PMCID: PMC4812752.
      View in: PubMed, PubMed Central
    4. Do M, Isaacson SA, McDermott G, Le Gros M, Larabell CA. Imaging and characterizing cells using tomography. Arch Biochem Biophys. 2015 Sep 01; 581:111-21. PMID: 25602704; PMCID: PMC4506273.
      View in: PubMed, PubMed Central
    5. Smith EA, McDermott G, Do M, Leung K, Panning B, Le Gros M, Larabell CA. Quantitatively imaging chromosomes by correlated cryo-fluorescence and soft x-ray tomographies. Biophys J. 2014 Oct 21; 107(8):1988-96. PMID: 25418180; PMCID: PMC4213715.
      View in: PubMed, PubMed Central
    6. Le Gros M, McDermott G, Cinquin BP, Smith EA, Do M, Chao WL, Naulleau PP, Larabell CA. Biological soft X-ray tomography on beamline 2.1 at the Advanced Light Source. J Synchrotron Radiat. 2014 Nov; 21(Pt 6):1370-7. PMID: 25343808; PMCID: PMC4211134.
      View in: PubMed, PubMed Central
    7. Cinquin BP, Do M, McDermott G, Walters AD, Myllys M, Smith EA, Cohen-Fix O, Le Gros M, Larabell CA. Putting molecules in their place. J Cell Biochem. 2014 Feb; 115(2):209-16. PMID: 23966233; PMCID: PMC3865101.
      View in: PubMed, PubMed Central
    8. Smith EA, Cinquin BP, Do M, McDermott G, Le Gros M, Larabell CA. Correlative cryogenic tomography of cells using light and soft x-rays. Ultramicroscopy. 2014 Aug; 143:33-40. PMID: 24355261; PMCID: PMC4013260.
      View in: PubMed, PubMed Central
    9. Isaacson SA, Larabell CA, Le Gros M, McQueen DM, Peskin CS. The influence of spatial variation in chromatin density determined by X-ray tomograms on the time to find DNA binding sites. Bull Math Biol. 2013 Nov; 75(11):2093-117. PMID: 23955281; PMCID: PMC3934756.
      View in: PubMed, PubMed Central
    10. Smith EA, Cinquin BP, McDermott G, Le Gros M, Parkinson DY, Kim HT, Larabell CA. Correlative microscopy methods that maximize specimen fidelity and data completeness, and improve molecular localization capabilities. J Struct Biol. 2013 Oct; 184(1):12-20. PMID: 23531637; PMCID: PMC3758393.
      View in: PubMed, PubMed Central
    11. Parkinson DY, Epperly LR, McDermott G, Le Gros M, Boudreau RM, Larabell CA. Nanoimaging cells using soft X-ray tomography. Methods Mol Biol. 2013; 950:457-81. PMID: 23086890.
      View in: PubMed
    12. Murphy SV, Lim R, Heraud P, Cholewa M, Le Gros M, de Jonge MD, Howard DL, Paterson D, McDonald C, Atala A, Jenkin G, Wallace EM. Human amnion epithelial cells induced to express functional cystic fibrosis transmembrane conductance regulator. PLoS One. 2012; 7(9):e46533. PMID: 23029546; PMCID: PMC3460882.
      View in: PubMed, PubMed Central
    13. McDermott G, Fox DM, Epperly L, Wetzler M, Barron AE, Le Gros M, Larabell CA. Visualizing and quantifying cell phenotype using soft X-ray tomography. Bioessays. 2012 Apr; 34(4):320-7. PMID: 22290620; PMCID: PMC3343367.
      View in: PubMed, PubMed Central
    14. McDermott G, Le Gros M, Larabell CA. Visualizing cell architecture and molecular location using soft x-ray tomography and correlated cryo-light microscopy. Annu Rev Phys Chem. 2012; 63:225-39. PMID: 22242730; PMCID: PMC3349341.
      View in: PubMed, PubMed Central
    15. Parkinson DY, Knoechel C, Yang C, Larabell CA, Le Gros M. Automatic alignment and reconstruction of images for soft X-ray tomography. J Struct Biol. 2012 Feb; 177(2):259-66. PMID: 22155289; PMCID: PMC3288662.
      View in: PubMed, PubMed Central
    16. Hanssen E, Knoechel C, Dearnley M, Dixon MW, Le Gros M, Larabell C, Tilley L. Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum. J Struct Biol. 2012 Feb; 177(2):224-32. PMID: 21945653; PMCID: PMC3349340.
      View in: PubMed, PubMed Central
    17. Uchida M, Sun Y, McDermott G, Knoechel C, Le Gros M, Parkinson D, Drubin DG, Larabell CA. Quantitative analysis of yeast internal architecture using soft X-ray tomography. Yeast. 2011 Mar; 28(3):227-36. PMID: 21360734; PMCID: PMC3404734.
      View in: PubMed, PubMed Central
    18. Uchida M, McDermott G, Wetzler M, Le Gros M, Myllys M, Knoechel C, Barron AE, Larabell CA. Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids in Candida albicans. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19375-80. PMID: 19880740; PMCID: PMC2780763.
      View in: PubMed, PubMed Central
    19. McDermott G, Le Gros M, Knoechel CG, Uchida M, Larabell CA. Soft X-ray tomography and cryogenic light microscopy: the cool combination in cellular imaging. Trends Cell Biol. 2009 Nov; 19(11):587-95. PMID: 19818625; PMCID: PMC3276488.
      View in: PubMed, PubMed Central
    20. Le Gros M, McDermott G, Uchida M, Knoechel CG, Larabell CA. High-aperture cryogenic light microscopy. J Microsc. 2009 Jul; 235(1):1-8. PMID: 19566622; PMCID: PMC3350647.
      View in: PubMed, PubMed Central
    21. Ashcroft JM, Gu W, Zhang T, Hughes SM, Hartman KB, Hofmann C, Kanaras AG, Kilcoyne DA, Le Gros M, Yin Y, Alivisatos AP, Larabell CA. TiO2 nanoparticles as a soft X-ray molecular probe. Chem Commun (Camb). 2008 Jun 07; (21):2471-3. PMID: 18491018; PMCID: PMC3355471.
      View in: PubMed, PubMed Central
    22. Parkinson DY, McDermott G, Etkin LD, Le Gros M, Larabell CA. Quantitative 3-D imaging of eukaryotic cells using soft X-ray tomography. J Struct Biol. 2008 Jun; 162(3):380-6. PMID: 18387313; PMCID: PMC2505111.
      View in: PubMed, PubMed Central
    23. Gu W, Etkin LD, Le Gros M, Larabell CA. X-ray tomography of Schizosaccharomyces pombe. Differentiation. 2007 Jul; 75(6):529-35. PMID: 17459084.
      View in: PubMed
    24. Fu A, Gu W, Boussert B, Koski K, Gerion D, Manna L, Le Gros M, Larabell CA, Alivisatos AP. Semiconductor quantum rods as single molecule fluorescent biological labels. Nano Lett. 2007 Jan; 7(1):179-82. PMID: 17212460; PMCID: PMC3984543.
      View in: PubMed, PubMed Central
    25. Gu W, Pellegrino T, Parak WJ, Boudreau R, Le Gros M, Alivisatos AP, Larabell CA. Measuring cell motility using quantum dot probes. Methods Mol Biol. 2007; 374:125-31. PMID: 17237535.
      View in: PubMed
    26. Le Gros M, McDermott G, Larabell CA. X-ray tomography of whole cells. Curr Opin Struct Biol. 2005 Oct; 15(5):593-600. PMID: 16153818.
      View in: PubMed
    27. Gu W, Pellegrino T, Parak WJ, Boudreau R, Le Gros M, Gerion D, Alivisatos AP, Larabell CA. Quantum-dot-based cell motility assay. Sci STKE. 2005 Jun 28; 2005(290):pl5. PMID: 15985641.
      View in: PubMed
    28. Larabell CA, Le Gros M. X-ray tomography generates 3-D reconstructions of the yeast, saccharomyces cerevisiae, at 60-nm resolution. Mol Biol Cell. 2004 Mar; 15(3):957-62. PMID: 14699066; PMCID: PMC363052.
      View in: PubMed, PubMed Central
    29. Pellegrino T, Parak WJ, Boudreau R, Le Gros M, Gerion D, Alivisatos AP, Larabell CA. Quantum dot-based cell motility assay. Differentiation. 2003 Dec; 71(9-10):542-8. PMID: 14686951.
      View in: PubMed
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