Mark Von Zastrow, MD, PhD

InstitutionUniversity of California San Francisco
Address600 16th Street
San Francisco CA 94158
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    Collapse Research 
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    Receptors and Second Messengers for Pain and Analgesia
    NIH/NINDS P01NS053709Sep 1, 2007 - Jun 30, 2013
    Role: Co-Investigator
    2007 Molecular Pharmacology Gordon Research Conference
    NIH R13DA022784Jan 15, 2007 - Dec 31, 2007
    Role: Principal Investigator
    Mechanisms Regulating Endocytosis of Opioid Receptors
    NIH R01DA012864Dec 1, 1999 - May 31, 2021
    Role: Principal Investigator
    Post-endocytic Sorting of Opioid Receptors
    NIH K02DA000439Sep 1, 1999 - Dec 30, 2010
    Role: Principal Investigator
    Membrane Trafficking of Opioid and Adrenergic Receptors
    NIH R01DA010711Jan 15, 1997 - Jan 31, 2019
    Role: Principal Investigator
    NIH R37DA010711Jan 15, 1997 - Jan 31, 2014
    Role: Principal Investigator
    NIH R29DA010711Jan 15, 1997 - Mar 31, 2004
    Role: Principal Investigator
    Presynaptic Mechanisms of Neural Plasticity
    NIH/NIDA P01DA010154Sep 30, 1995 - Apr 30, 2017
    Role: Co-Investigator
    NIH K21DA000218Sep 30, 1994 - Aug 31, 1999
    Role: Principal Investigator
    Extracellular Matrix Protein enhancement of Phagocytosis
    NIH R01GM038330Dec 1, 1986 - Nov 30, 2007
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018 Feb; 50(2):180-185. PMID: 29311635.
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    2. Kim MW, Wang W, Sanchez MI, Coukos R, von Zastrow M, Ting AY. Time-gated detection of protein-protein interactions with transcriptional readout. Elife. 2017 Nov 30; 6. PMID: 29189201.
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    3. O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS. Genetic evidence that ß-arrestins are dispensable for the initiation of ß2-adrenergic receptor signaling to ERK. Sci Signal. 2017 Jun 20; 10(484). PMID: 28634209.
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    4. Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M. Functional selectivity of GPCR-directed drug action through location bias. Nat Chem Biol. 2017 Jul; 13(7):799-806. PMID: 28553949.
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    5. Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ. An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell. 2017 Apr 06; 169(2):350-360.e12. PMID: 28388416.
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    6. Tsvetanova NG, Trester-Zedlitz M, Newton BW, Riordan DP, Sundaram AB, Johnson JR, Krogan NJ, von Zastrow M. G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. Mol Pharmacol. 2017 Feb; 91(2):145-156. PMID: 27879340.
      View in: PubMed
    7. Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M. Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling. Mol Pharmacol. 2017 Jan; 91(1):65-73. PMID: 27821547.
      View in: PubMed
    8. Gendron L, Cahill CM, von Zastrow M, Schiller PW, Pineyro G. Molecular Pharmacology of d-Opioid Receptors. Pharmacol Rev. 2016 07; 68(3):631-700. PMID: 27343248; PMCID: PMC4931872 [Available on 07/01/17].
    9. Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. The a-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor. J Biol Chem. 2016 Jul 08; 291(28):14510-25. PMID: 27226565; PMCID: PMC4938174 [Available on 07/08/17].
    10. Leaf A, Von Zastrow M. Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia. Elife. 2015 Jul 16; 4. PMID: 26182404; PMCID: PMC4547097.
    11. Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M. Effects of endocytosis on receptor-mediated signaling. Curr Opin Cell Biol. 2015 Aug; 35:137-43. PMID: 26057614; PMCID: PMC4529812.
    12. Koliwer J, Park M, Bauch C, von Zastrow M, Kreienkamp HJ. The golgi-associated PDZ domain protein PIST/GOPC stabilizes the ß1-adrenergic receptor in intracellular compartments after internalization. J Biol Chem. 2015 Mar 06; 290(10):6120-9. PMID: 25614626; PMCID: PMC4358252.
    13. Tsvetanova NG, Irannejad R, von Zastrow M. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem. 2015 Mar 13; 290(11):6689-96. PMID: 25605726; PMCID: PMC4358092.
    14. Tsvetanova NG, von Zastrow M. Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat Chem Biol. 2014 Dec; 10(12):1061-5. PMID: 25362359; PMCID: PMC4232470.
    15. Di Fiore PP, von Zastrow M. Endocytosis, signaling, and beyond. Cold Spring Harb Perspect Biol. 2014 Aug 01; 6(8). PMID: 25085911; PMCID: PMC4107983.
    16. Choy RW, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M. Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron. 2014 Apr 02; 82(1):55-62. PMID: 24698268; PMCID: PMC4029335.
    17. Benovic JL, von Zastrow M. Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors. Curr Opin Cell Biol. 2014 Apr; 27:v-vi. PMID: 24529749.
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    18. Irannejad R, Kotowski SJ, von Zastrow M. Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol. 2014; 535:403-18. PMID: 24377936; PMCID: PMC4023871.
    19. Irannejad R, von Zastrow M. GPCR signaling along the endocytic pathway. Curr Opin Cell Biol. 2014 Apr; 27:109-16. PMID: 24680436; PMCID: PMC4968408.
    20. Marley A, Choy RW, von Zastrow M. GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. PLoS One. 2013; 8(8):e70857. PMID: 23936473; PMCID: PMC3732291.
    21. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013 Mar 28; 495(7442):534-8. PMID: 23515162; PMCID: PMC3835555.
    22. Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ. Regulation of µ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev. 2013 Jan; 65(1):223-54. PMID: 23321159; PMCID: PMC3565916.
    23. Just S, Illing S, Trester-Zedlitz M, Lau EK, Kotowski SJ, Miess E, Mann A, Doll C, Trinidad JC, Burlingame AL, von Zastrow M, Schulz S. Differentiation of opioid drug effects by hierarchical multi-site phosphorylation. Mol Pharmacol. 2013 Mar; 83(3):633-9. PMID: 23239825; PMCID: PMC3583494.
    24. von Zastrow M, Williams JT. Modulating neuromodulation by receptor membrane traffic in the endocytic pathway. Neuron. 2012 Oct 04; 76(1):22-32. PMID: 23040804; PMCID: PMC3496082.
    25. Marley A, von Zastrow M. A simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary cilia. PLoS One. 2012; 7(10):e46647. PMID: 23056384; PMCID: PMC3463515.
    26. Henry AG, Hislop JN, Grove J, Thorn K, Marsh M, von Zastrow M. Regulation of endocytic clathrin dynamics by cargo ubiquitination. Dev Cell. 2012 Sep 11; 23(3):519-32. PMID: 22940114; PMCID: PMC3470869.
    27. Avasthi P, Marley A, Lin H, Gregori-Puigjane E, Shoichet BK, von Zastrow M, Marshall WF. A chemical screen identifies class a g-protein coupled receptors as regulators of cilia. ACS Chem Biol. 2012 May 18; 7(5):911-9. PMID: 22375814; PMCID: PMC3356477.
    28. Hislop JN, Henry AG, von Zastrow M. Ubiquitination in the first cytoplasmic loop of µ-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation. J Biol Chem. 2011 Nov 18; 286(46):40193-204. PMID: 21953467; PMCID: PMC3220576.
    29. Lau EK, Trester-Zedlitz M, Trinidad JC, Kotowski SJ, Krutchinsky AN, Burlingame AL, von Zastrow M. Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection. Sci Signal. 2011 Aug 09; 4(185):ra52. PMID: 21868358; PMCID: PMC3625704.
    30. Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M. Endocytosis promotes rapid dopaminergic signaling. Neuron. 2011 Jul 28; 71(2):278-90. PMID: 21791287; PMCID: PMC3417347.
    31. Temkin P, Lauffer B, Jäger S, Cimermancic P, Krogan NJ, von Zastrow M. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol. 2011 Jun; 13(6):715-21. PMID: 21602791; PMCID: PMC3113693.
    32. Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT. Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone. J Neurosci. 2011 Mar 23; 31(12):4434-43. PMID: 21430144; PMCID: PMC3092436.
    33. Yudowski GA, von Zastrow M. Investigating G protein-coupled receptor endocytosis and trafficking by TIR-FM. Methods Mol Biol. 2011; 756:325-32. PMID: 21870236; PMCID: PMC3308188.
    34. Hislop JN, von Zastrow M. Analysis of GPCR localization and trafficking. Methods Mol Biol. 2011; 746:425-40. PMID: 21607873; PMCID: PMC4960980.
    35. Romero G, von Zastrow M, Friedman PA. Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity. Adv Pharmacol. 2011; 62:279-314. PMID: 21907913; PMCID: PMC4968410.
    36. Henry AG, White IJ, Marsh M, von Zastrow M, Hislop JN. The role of ubiquitination in lysosomal trafficking of d-opioid receptors. Traffic. 2011 Feb; 12(2):170-84. PMID: 21106040; PMCID: PMC3075729.
    37. Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73. PMID: 21111236; PMCID: PMC3058345.
    38. Tzingounis AV, von Zastrow M, Yudowski GA. {Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism. Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):21028-33. PMID: 21078978; PMCID: PMC3000286.
    39. Hislop JN, von Zastrow M. Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors. Traffic. 2011 Feb; 12(2):137-48. PMID: 20854416; PMCID: PMC3625703.
    40. Yu YJ, Dhavan R, Chevalier MW, Yudowski GA, von Zastrow M. Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion. J Neurosci. 2010 Sep 01; 30(35):11703-14. PMID: 20810891; PMCID: PMC2943418.
    41. Lauffer BE, Melero C, Temkin P, Lei C, Hong W, Kortemme T, von Zastrow M. SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J Cell Biol. 2010 Aug 23; 190(4):565-74. PMID: 20733053; PMCID: PMC2928020.
    42. Marley A, von Zastrow M. DISC1 regulates primary cilia that display specific dopamine receptors. PLoS One. 2010 May 28; 5(5):e10902. PMID: 20531939; PMCID: PMC2878344.
    43. von Zastrow M. Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications. Drug Alcohol Depend. 2010 May 01; 108(3):166-71. PMID: 20338697; PMCID: PMC3417350.
    44. Garriock HA, Tanowitz M, Kraft JB, Dang VC, Peters EJ, Jenkins GD, Reinalda MS, McGrath PJ, von Zastrow M, Slager SL, Hamilton SP. Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder. Am J Psychiatry. 2010 May; 167(5):565-73. PMID: 20194481; PMCID: PMC2885766.
    45. Marley A, von Zastrow M. Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes. PLoS One. 2010 Feb 19; 5(2):e9325. PMID: 20174469; PMCID: PMC2824829.
    46. Rochdi MD, Vargas GA, Carpentier E, Oligny-Longpré G, Chen S, Kovoor A, Gitelman SE, Rosenthal SM, von Zastrow M, Bouvier M. Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments. Mol Pharmacol. 2010 May; 77(5):836-45. PMID: 20159941; PMCID: PMC2872969.
    47. Sorkin A, von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol. 2009 Sep; 10(9):609-22. PMID: 19696798; PMCID: PMC2895425.
    48. Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J Biol Chem. 2009 Oct 23; 284(43):29860-72. PMID: 19710023; PMCID: PMC2785616.
    49. Hislop JN, Henry AG, Marchese A, von Zastrow M. Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. J Biol Chem. 2009 Jul 17; 284(29):19361-70. PMID: 19433584; PMCID: PMC2740561.
    50. Yudowski GA, Puthenveedu MA, Henry AG, von Zastrow M. Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway. Mol Biol Cell. 2009 Jun; 20(11):2774-84. PMID: 19369423; PMCID: PMC2688556.
    51. Yu YJ, Arttamangkul S, Evans CJ, Williams JT, von Zastrow M. Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons. J Neurosci. 2009 Jan 07; 29(1):222-33. PMID: 19129399; PMCID: PMC2775560.
    52. Lauffer BE, Chen S, Melero C, Kortemme T, von Zastrow M, Vargas GA. Engineered protein connectivity to actin mimics PDZ-dependent recycling of G protein-coupled receptors but not its regulation by Hrs. J Biol Chem. 2009 Jan 23; 284(4):2448-58. PMID: 19001361; PMCID: PMC2629119.
    53. Tanowitz M, Hislop JN, von Zastrow M. Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors. J Biol Chem. 2008 Dec 19; 283(51):35614-21. PMID: 18936093; PMCID: PMC2602910.
    54. Arttamangkul S, Quillinan N, Low MJ, von Zastrow M, Pintar J, Williams JT. Differential activation and trafficking of micro-opioid receptors in brain slices. Mol Pharmacol. 2008 Oct; 74(4):972-9. PMID: 18612077; PMCID: PMC3125947.
    55. N'Diaye EN, Hanyaloglu AC, Kajihara KK, Puthenveedu MA, Wu P, von Zastrow M, Brown EJ. The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis. Mol Biol Cell. 2008 Mar; 19(3):1252-60. PMID: 18199683; PMCID: PMC2262968.
    56. Hanyaloglu AC, von Zastrow M. Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu Rev Pharmacol Toxicol. 2008; 48:537-68. PMID: 18184106.
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    57. Yudowski GA, Puthenveedu MA, Leonoudakis D, Panicker S, Thorn KS, Beattie EC, von Zastrow M. Real-time imaging of discrete exocytic events mediating surface delivery of AMPA receptors. J Neurosci. 2007 Oct 10; 27(41):11112-21. PMID: 17928453; PMCID: PMC3249441.
    58. Puthenveedu MA, Yudowski GA, von Zastrow M. Endocytosis of neurotransmitter receptors: location matters. Cell. 2007 Sep 21; 130(6):988-9. PMID: 17889644.
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    59. von Zastrow M, Sorkin A. Signaling on the endocytic pathway. Curr Opin Cell Biol. 2007 Aug; 19(4):436-45. PMID: 17662591; PMCID: PMC1992519.
    60. Wang Y, Lauffer B, Von Zastrow M, Kobilka BK, Xiang Y. N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. Mol Pharmacol. 2007 Aug; 72(2):429-39. PMID: 17510209.
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    61. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell. 2007 Feb 09; 128(3):547-60. PMID: 17289573; PMCID: PMC1955433.
    62. Hanyaloglu AC, von Zastrow M. A novel sorting sequence in the beta2-adrenergic receptor switches recycling from default to the Hrs-dependent mechanism. J Biol Chem. 2007 Feb 02; 282(5):3095-104. PMID: 17138565.
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    63. Puthenveedu MA, von Zastrow M. Cargo regulates clathrin-coated pit dynamics. Cell. 2006 Oct 06; 127(1):113-24. PMID: 17018281.
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    64. Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther. 2007 Jan; 320(1):1-13. PMID: 16803859.
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    65. Yudowski GA, Puthenveedu MA, von Zastrow M. Distinct modes of regulated receptor insertion to the somatodendritic plasma membrane. Nat Neurosci. 2006 May; 9(5):622-7. PMID: 16604070.
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    66. Urban JD, Vargas GA, von Zastrow M, Mailman RB. Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways. Neuropsychopharmacology. 2007 Jan; 32(1):67-77. PMID: 16554739.
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    67. Haberstock-Debic H, Kim KA, Yu YJ, von Zastrow M. Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. J Neurosci. 2005 Aug 24; 25(34):7847-57. PMID: 16120787.
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    68. Kenski DM, Zhang C, von Zastrow M, Shokat KM. Chemical genetic engineering of G protein-coupled receptor kinase 2. J Biol Chem. 2005 Oct 14; 280(41):35051-61. PMID: 16081410.
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    69. Hanyaloglu AC, McCullagh E, von Zastrow M. Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling. EMBO J. 2005 Jul 06; 24(13):2265-83. PMID: 15944737; PMCID: PMC1173141.
    70. Trester-Zedlitz M, Burlingame A, Kobilka B, von Zastrow M. Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. Biochemistry. 2005 Apr 26; 44(16):6133-43. PMID: 15835901.
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    71. Gage RM, Matveeva EA, Whiteheart SW, von Zastrow M. Type I PDZ ligands are sufficient to promote rapid recycling of G Protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor. J Biol Chem. 2005 Feb 04; 280(5):3305-13. PMID: 15548537.
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    72. Cao TT, Brelot A, von Zastrow M. The composition of the beta-2 adrenergic receptor oligomer affects its membrane trafficking after ligand-induced endocytosis. Mol Pharmacol. 2005 Jan; 67(1):288-97. PMID: 15492118.
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    73. Vargas GA, Von Zastrow M. Identification of a novel endocytic recycling signal in the D1 dopamine receptor. J Biol Chem. 2004 Sep 03; 279(36):37461-9. PMID: 15192107.
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    74. Hislop JN, Marley A, Von Zastrow M. Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes. J Biol Chem. 2004 May 21; 279(21):22522-31. PMID: 15024011.
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    75. von Zastrow M. Opioid receptor regulation. Neuromolecular Med. 2004; 5(1):51-8. PMID: 15001812.
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    76. Tanowitz M, von Zastrow M. Identification of protein interactions by yeast two-hybrid screening and coimmunoprecipitation. Methods Mol Biol. 2004; 259:353-69. PMID: 15250504.
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    77. von Zastrow M. A cell biologist's perspective on physiological adaptation to opiate drugs. Neuropharmacology. 2004; 47 Suppl 1:286-92. PMID: 15464144.
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    78. von Zastrow M. Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway. Life Sci. 2003 Dec 05; 74(2-3):217-24. PMID: 14607249.
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    79. Tanowitz M, von Zastrow M. A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors. J Biol Chem. 2003 Nov 14; 278(46):45978-86. PMID: 12939277.
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    80. Elenko E, Fischer T, Niesman I, Harding T, McQuistan T, Von Zastrow M, Farquhar MG. Spatial regulation of Galphai protein signaling in clathrin-coated membrane microdomains containing GAIP. Mol Pharmacol. 2003 Jul; 64(1):11-20. PMID: 12815156.
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    81. von Zastrow M, Svingos A, Haberstock-Debic H, Evans C. Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs. Curr Opin Neurobiol. 2003 Jun; 13(3):348-53. PMID: 12850220.
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    82. Haberstock-Debic H, Wein M, Barrot M, Colago EE, Rahman Z, Neve RL, Pickel VM, Nestler EJ, von Zastrow M, Svingos AL. Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons. J Neurosci. 2003 May 15; 23(10):4324-32. PMID: 12764121.
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    83. Kim KA, von Zastrow M. Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells. J Neurosci. 2003 Mar 15; 23(6):2075-85. PMID: 12657666.
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    84. Whistler JL, Gerber BO, Meng EC, Baranski TJ, von Zastrow M, Bourne HR. Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic. 2002 Dec; 3(12):866-77. PMID: 12453150.
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    85. Tanowitz M, Von Zastrow M. Ubiquitination-independent trafficking of G protein-coupled receptors to lysosomes. J Biol Chem. 2002 Dec 27; 277(52):50219-22. PMID: 12401797.
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    86. Xia H, von Zastrow M, Malenka RC. A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors. J Biol Chem. 2002 Dec 06; 277(49):47765-9. PMID: 12368290.
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    87. Sorkin A, Von Zastrow M. Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol. 2002 Aug; 3(8):600-14. PMID: 12154371.
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    88. Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M. Modulation of postendocytic sorting of G protein-coupled receptors. Science. 2002 Jul 26; 297(5581):615-20. PMID: 12142540.
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    89. Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, Williams JT. mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization. J Neurosci. 2002 Jul 01; 22(13):5769-76. PMID: 12097530.
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    90. Beattie EC, Stellwagen D, Morishita W, Bresnahan JC, Ha BK, Von Zastrow M, Beattie MS, Malenka RC. Control of synaptic strength by glial TNFalpha. Science. 2002 Mar 22; 295(5563):2282-5. PMID: 11910117.
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    91. He L, Fong J, von Zastrow M, Whistler JL. Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell. 2002 Jan 25; 108(2):271-82. PMID: 11832216.
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