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Mark Von Zastrow, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentPsychiatry
Address600 16th Street
San Francisco CA 94158
Phone415-476-7855
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    Collapse Research 
    Collapse Research Activities and Funding
    Receptors and Second Messengers for Pain and Analgesia
    NIH/NINDS P01NS053709Sep 1, 2007 - Jun 30, 2013
    Role: Co-Investigator
    2007 Molecular Pharmacology Gordon Research Conference
    NIH R13DA022784Jan 15, 2007 - Dec 31, 2007
    Role: Principal Investigator
    Mechanisms Regulating Endocytosis of Opioid Receptors
    NIH R01DA012864Dec 1, 1999 - May 31, 2021
    Role: Principal Investigator
    Post-endocytic Sorting of Opioid Receptors
    NIH K02DA000439Sep 1, 1999 - Dec 30, 2010
    Role: Principal Investigator
    Membrane Trafficking of Opioid and Adrenergic Receptors
    NIH R01DA010711Jan 15, 1997 - Jan 31, 2019
    Role: Principal Investigator
    MEMBRANE TRAFFICKING OF OPIOID RECEPTORS
    NIH R37DA010711Jan 15, 1997 - Jan 31, 2014
    Role: Principal Investigator
    MEMBRANE TRAFFICKING OF OPIOID RECEPTORS
    NIH R29DA010711Jan 15, 1997 - Mar 31, 2004
    Role: Principal Investigator
    Presynaptic Mechanisms of Neural Plasticity
    NIH/NIDA P01DA010154Sep 30, 1995 - Apr 30, 2017
    Role: Co-Investigator
    MECHANISMS OF RECEPTOR INTERNALIZATION IN DRUG ADDICTION
    NIH K21DA000218Sep 30, 1994 - Aug 31, 1999
    Role: Principal Investigator
    Extracellular Matrix Protein enhancement of Phagocytosis
    NIH R01GM038330Dec 1, 1986 - Nov 30, 2007
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M. Functional selectivity of GPCR-directed drug action through location bias. Nat Chem Biol. 2017 May 29. PMID: 28553949.
      View in: PubMed
    2. Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ. An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell. 2017 Apr 06; 169(2):350-360.e12. PMID: 28388416.
      View in: PubMed
    3. Tsvetanova NG, Trester-Zedlitz M, Newton BW, Riordan DP, Sundaram AB, Johnson JR, Krogan NJ, von Zastrow M. GPCR endocytosis confers uniformity in responses to chemically distinct ligands. Mol Pharmacol. 2016 Nov 22. PMID: 27879340.
      View in: PubMed
    4. Uchida Y, Rutaganira FU, Jullie D, Shokat KM, von Zastrow M. Endosomal phosphatidylinositol 3-kinase is essential for canonical GPCR signaling. Mol Pharmacol. 2016 Nov 7. PMID: 27821547.
      View in: PubMed
    5. Varandas KC, Irannejad R, von Zastrow M. Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs. Curr Biol. 2016 Nov 4. PMID: 27839977.
      View in: PubMed
    6. Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. GIV/Girdin activates Gai and inhibits Gas via the same motif. Proc Natl Acad Sci U S A. 2016 Sep 27; 113(39):E5721-30. PMID: 27621449.
      View in: PubMed
    7. Gendron L, Cahill CM, von Zastrow M, Schiller PW, Pineyro G. Molecular Pharmacology of d-Opioid Receptors. Pharmacol Rev. 2016 Jul; 68(3):631-700. PMID: 27343248.
      View in: PubMed
    8. Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. The a-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor. J Biol Chem. 2016 Jul 8; 291(28):14510-25. PMID: 27226565.
      View in: PubMed
    9. Eichel K, Jullié D, von Zastrow M. ß-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation. Nat Cell Biol. 2016 Mar; 18(3):303-10. PMID: 26829388.
      View in: PubMed
    10. Leaf A, Von Zastrow M. Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia. Elife. 2015; 4. PMID: 26182404; PMCID: PMC4547097.
      View in: PubMed, PubMed Central
    11. Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M. Effects of endocytosis on receptor-mediated signaling. Curr Opin Cell Biol. 2015 Aug; 35:137-43. PMID: 26057614; PMCID: PMC4529812 [Available on 08/01/16].
      View in: PubMed, PubMed Central
    12. Koliwer J, Park M, Bauch C, von Zastrow M, Kreienkamp HJ. The golgi-associated PDZ domain protein PIST/GOPC stabilizes the ß1-adrenergic receptor in intracellular compartments after internalization. J Biol Chem. 2015 Mar 6; 290(10):6120-9. PMID: 25614626; PMCID: PMC4358252 [Available on 03/06/16].
      View in: PubMed, PubMed Central
    13. Tsvetanova NG, Irannejad R, von Zastrow M. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem. 2015 Mar 13; 290(11):6689-96. PMID: 25605726; PMCID: PMC4358092 [Available on 03/13/16].
      View in: PubMed, PubMed Central
    14. Tsvetanova NG, von Zastrow M. Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat Chem Biol. 2014 Dec; 10(12):1061-5. PMID: 25362359; PMCID: PMC4232470.
      View in: PubMed, PubMed Central
    15. Di Fiore PP, von Zastrow M. Endocytosis, signaling, and beyond. Cold Spring Harb Perspect Biol. 2014 Aug; 6(8). PMID: 25085911.
      View in: PubMed
    16. Choy RW, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M. Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron. 2014 Apr 2; 82(1):55-62. PMID: 24698268; PMCID: PMC4029335.
      View in: PubMed, PubMed Central
    17. Benovic JL, von Zastrow M. Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors. Curr Opin Cell Biol. 2014 Apr; 27:v-vi. PMID: 24529749.
      View in: PubMed
    18. Irannejad R, Kotowski SJ, von Zastrow M. Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol. 2014; 535:403-18. PMID: 24377936; PMCID: PMC4023871.
      View in: PubMed, PubMed Central
    19. Irannejad R, von Zastrow M. GPCR signaling along the endocytic pathway. Curr Opin Cell Biol. 2014 Apr; 27:109-16. PMID: 24680436.
      View in: PubMed
    20. Marley A, Choy RW, von Zastrow M. GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. PLoS One. 2013; 8(8):e70857. PMID: 23936473; PMCID: PMC3732291.
      View in: PubMed, PubMed Central
    21. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013 Mar 28; 495(7442):534-8. PMID: 23515162; PMCID: PMC3835555.
      View in: PubMed, PubMed Central
    22. Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ. Regulation of µ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev. 2013 Jan; 65(1):223-54. PMID: 23321159; PMCID: PMC3565916.
      View in: PubMed, PubMed Central
    23. Just S, Illing S, Trester-Zedlitz M, Lau EK, Kotowski SJ, Miess E, Mann A, Doll C, Trinidad JC, Burlingame AL, von Zastrow M, Schulz S. Differentiation of opioid drug effects by hierarchical multi-site phosphorylation. Mol Pharmacol. 2013 Mar; 83(3):633-9. PMID: 23239825; PMCID: PMC3583494.
      View in: PubMed, PubMed Central
    24. von Zastrow M, Williams JT. Modulating neuromodulation by receptor membrane traffic in the endocytic pathway. Neuron. 2012 Oct 4; 76(1):22-32. PMID: 23040804; PMCID: PMC3496082.
      View in: PubMed, PubMed Central
    25. Marley A, von Zastrow M. A simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary cilia. PLoS One. 2012; 7(10):e46647. PMID: 23056384; PMCID: PMC3463515.
      View in: PubMed, PubMed Central
    26. Henry AG, Hislop JN, Grove J, Thorn K, Marsh M, von Zastrow M. Regulation of endocytic clathrin dynamics by cargo ubiquitination. Dev Cell. 2012 Sep 11; 23(3):519-32. PMID: 22940114; PMCID: PMC3470869.
      View in: PubMed, PubMed Central
    27. Avasthi P, Marley A, Lin H, Gregori-Puigjane E, Shoichet BK, von Zastrow M, Marshall WF. A chemical screen identifies class a g-protein coupled receptors as regulators of cilia. ACS Chem Biol. 2012 May 18; 7(5):911-9. PMID: 22375814; PMCID: PMC3356477.
      View in: PubMed, PubMed Central
    28. Hislop JN, Henry AG, von Zastrow M. Ubiquitination in the first cytoplasmic loop of µ-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation. J Biol Chem. 2011 Nov 18; 286(46):40193-204. PMID: 21953467; PMCID: PMC3220576.
      View in: PubMed, PubMed Central
    29. Lau EK, Trester-Zedlitz M, Trinidad JC, Kotowski SJ, Krutchinsky AN, Burlingame AL, von Zastrow M. Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection. Sci Signal. 2011 Aug 9; 4(185):ra52. PMID: 21868358; PMCID: PMC3625704.
      View in: PubMed, PubMed Central
    30. Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M. Endocytosis promotes rapid dopaminergic signaling. Neuron. 2011 Jul 28; 71(2):278-90. PMID: 21791287; PMCID: PMC3417347.
      View in: PubMed, PubMed Central
    31. Temkin P, Lauffer B, Jäger S, Cimermancic P, Krogan NJ, von Zastrow M. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol. 2011 Jun; 13(6):715-21. PMID: 21602791; PMCID: PMC3113693.
      View in: PubMed, PubMed Central
    32. Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT. Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone. J Neurosci. 2011 Mar 23; 31(12):4434-43. PMID: 21430144; PMCID: PMC3092436.
      View in: PubMed, PubMed Central
    33. Romero G, von Zastrow M, Friedman PA. Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity. Adv Pharmacol. 2011; 62:279-314. PMID: 21907913.
      View in: PubMed
    34. Hislop JN, von Zastrow M. Analysis of GPCR localization and trafficking. Methods Mol Biol. 2011; 746:425-40. PMID: 21607873.
      View in: PubMed
    35. Yudowski GA, von Zastrow M. Investigating G protein-coupled receptor endocytosis and trafficking by TIR-FM. Methods Mol Biol. 2011; 756:325-32. PMID: 21870236; PMCID: PMC3308188.
      View in: PubMed, PubMed Central
    36. Henry AG, White IJ, Marsh M, von Zastrow M, Hislop JN. The role of ubiquitination in lysosomal trafficking of d-opioid receptors. Traffic. 2011 Feb; 12(2):170-84. PMID: 21106040; PMCID: PMC3075729.
      View in: PubMed, PubMed Central
    37. Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73. PMID: 21111236; PMCID: PMC3058345.
      View in: PubMed, PubMed Central
    38. Tzingounis AV, von Zastrow M, Yudowski GA. {Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism. Proc Natl Acad Sci U S A. 2010 Dec 7; 107(49):21028-33. PMID: 21078978; PMCID: PMC3000286.
      View in: PubMed, PubMed Central
    39. Hislop JN, von Zastrow M. Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors. Traffic. 2011 Feb; 12(2):137-48. PMID: 20854416; PMCID: PMC3625703.
      View in: PubMed, PubMed Central
    40. Yu YJ, Dhavan R, Chevalier MW, Yudowski GA, von Zastrow M. Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion. J Neurosci. 2010 Sep 1; 30(35):11703-14. PMID: 20810891; PMCID: PMC2943418.
      View in: PubMed, PubMed Central
    41. Lauffer BE, Melero C, Temkin P, Lei C, Hong W, Kortemme T, von Zastrow M. SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J Cell Biol. 2010 Aug 23; 190(4):565-74. PMID: 20733053; PMCID: PMC2928020.
      View in: PubMed, PubMed Central
    42. Marley A, von Zastrow M. DISC1 regulates primary cilia that display specific dopamine receptors. PLoS One. 2010; 5(5):e10902. PMID: 20531939; PMCID: PMC2878344.
      View in: PubMed, PubMed Central
    43. von Zastrow M. Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications. Drug Alcohol Depend. 2010 May 1; 108(3):166-71. PMID: 20338697; PMCID: PMC3417350.
      View in: PubMed, PubMed Central
    44. Garriock HA, Tanowitz M, Kraft JB, Dang VC, Peters EJ, Jenkins GD, Reinalda MS, McGrath PJ, von Zastrow M, Slager SL, Hamilton SP. Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder. Am J Psychiatry. 2010 May; 167(5):565-73. PMID: 20194481; PMCID: PMC2885766.
      View in: PubMed, PubMed Central
    45. Marley A, von Zastrow M. Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes. PLoS One. 2010; 5(2):e9325. PMID: 20174469; PMCID: PMC2824829.
      View in: PubMed, PubMed Central
    46. Rochdi MD, Vargas GA, Carpentier E, Oligny-Longpré G, Chen S, Kovoor A, Gitelman SE, Rosenthal SM, von Zastrow M, Bouvier M. Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments. Mol Pharmacol. 2010 May; 77(5):836-45. PMID: 20159941; PMCID: PMC2872969.
      View in: PubMed, PubMed Central
    47. Sorkin A, von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol. 2009 Sep; 10(9):609-22. PMID: 19696798; PMCID: PMC2895425.
      View in: PubMed, PubMed Central
    48. Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J Biol Chem. 2009 Oct 23; 284(43):29860-72. PMID: 19710023; PMCID: PMC2785616.
      View in: PubMed, PubMed Central
    49. Hislop JN, Henry AG, Marchese A, von Zastrow M. Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. J Biol Chem. 2009 Jul 17; 284(29):19361-70. PMID: 19433584; PMCID: PMC2740561.
      View in: PubMed, PubMed Central
    50. Yudowski GA, Puthenveedu MA, Henry AG, von Zastrow M. Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway. Mol Biol Cell. 2009 Jun; 20(11):2774-84. PMID: 19369423; PMCID: PMC2688556.
      View in: PubMed, PubMed Central
    51. Yu YJ, Arttamangkul S, Evans CJ, Williams JT, von Zastrow M. Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons. J Neurosci. 2009 Jan 7; 29(1):222-33. PMID: 19129399; PMCID: PMC2775560.
      View in: PubMed, PubMed Central
    52. Lauffer BE, Chen S, Melero C, Kortemme T, von Zastrow M, Vargas GA. Engineered protein connectivity to actin mimics PDZ-dependent recycling of G protein-coupled receptors but not its regulation by Hrs. J Biol Chem. 2009 Jan 23; 284(4):2448-58. PMID: 19001361; PMCID: PMC2629119.
      View in: PubMed, PubMed Central
    53. Tanowitz M, Hislop JN, von Zastrow M. Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors. J Biol Chem. 2008 Dec 19; 283(51):35614-21. PMID: 18936093; PMCID: PMC2602910.
      View in: PubMed, PubMed Central
    54. Arttamangkul S, Quillinan N, Low MJ, von Zastrow M, Pintar J, Williams JT. Differential activation and trafficking of micro-opioid receptors in brain slices. Mol Pharmacol. 2008 Oct; 74(4):972-9. PMID: 18612077; PMCID: PMC3125947.
      View in: PubMed, PubMed Central
    55. N'Diaye EN, Hanyaloglu AC, Kajihara KK, Puthenveedu MA, Wu P, von Zastrow M, Brown EJ. The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis. Mol Biol Cell. 2008 Mar; 19(3):1252-60. PMID: 18199683; PMCID: PMC2262968.
      View in: PubMed, PubMed Central
    56. Hanyaloglu AC, von Zastrow M. Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu Rev Pharmacol Toxicol. 2008; 48:537-68. PMID: 18184106.
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    57. Yudowski GA, Puthenveedu MA, Leonoudakis D, Panicker S, Thorn KS, Beattie EC, von Zastrow M. Real-time imaging of discrete exocytic events mediating surface delivery of AMPA receptors. J Neurosci. 2007 Oct 10; 27(41):11112-21. PMID: 17928453; PMCID: PMC3249441.
      View in: PubMed, PubMed Central
    58. Puthenveedu MA, Yudowski GA, von Zastrow M. Endocytosis of neurotransmitter receptors: location matters. Cell. 2007 Sep 21; 130(6):988-9. PMID: 17889644.
      View in: PubMed
    59. von Zastrow M, Sorkin A. Signaling on the endocytic pathway. Curr Opin Cell Biol. 2007 Aug; 19(4):436-45. PMID: 17662591; PMCID: PMC1992519.
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    60. Wang Y, Lauffer B, Von Zastrow M, Kobilka BK, Xiang Y. N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. Mol Pharmacol. 2007 Aug; 72(2):429-39. PMID: 17510209.
      View in: PubMed
    61. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell. 2007 Feb 9; 128(3):547-60. PMID: 17289573; PMCID: PMC1955433.
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    62. Hanyaloglu AC, von Zastrow M. A novel sorting sequence in the beta2-adrenergic receptor switches recycling from default to the Hrs-dependent mechanism. J Biol Chem. 2007 Feb 2; 282(5):3095-104. PMID: 17138565.
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    63. Puthenveedu MA, von Zastrow M. Cargo regulates clathrin-coated pit dynamics. Cell. 2006 Oct 6; 127(1):113-24. PMID: 17018281.
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    64. Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther. 2007 Jan; 320(1):1-13. PMID: 16803859.
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    65. Yudowski GA, Puthenveedu MA, von Zastrow M. Distinct modes of regulated receptor insertion to the somatodendritic plasma membrane. Nat Neurosci. 2006 May; 9(5):622-7. PMID: 16604070.
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    66. Urban JD, Vargas GA, von Zastrow M, Mailman RB. Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways. Neuropsychopharmacology. 2007 Jan; 32(1):67-77. PMID: 16554739.
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    67. Haberstock-Debic H, Kim KA, Yu YJ, von Zastrow M. Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. J Neurosci. 2005 Aug 24; 25(34):7847-57. PMID: 16120787.
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    68. Kenski DM, Zhang C, von Zastrow M, Shokat KM. Chemical genetic engineering of G protein-coupled receptor kinase 2. J Biol Chem. 2005 Oct 14; 280(41):35051-61. PMID: 16081410.
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    69. Hanyaloglu AC, McCullagh E, von Zastrow M. Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling. EMBO J. 2005 Jul 6; 24(13):2265-83. PMID: 15944737; PMCID: PMC1173141.
      View in: PubMed, PubMed Central
    70. Trester-Zedlitz M, Burlingame A, Kobilka B, von Zastrow M. Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. Biochemistry. 2005 Apr 26; 44(16):6133-43. PMID: 15835901.
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    71. Gage RM, Matveeva EA, Whiteheart SW, von Zastrow M. Type I PDZ ligands are sufficient to promote rapid recycling of G Protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor. J Biol Chem. 2005 Feb 4; 280(5):3305-13. PMID: 15548537.
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    72. Cao TT, Brelot A, von Zastrow M. The composition of the beta-2 adrenergic receptor oligomer affects its membrane trafficking after ligand-induced endocytosis. Mol Pharmacol. 2005 Jan; 67(1):288-97. PMID: 15492118.
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    73. Vargas GA, Von Zastrow M. Identification of a novel endocytic recycling signal in the D1 dopamine receptor. J Biol Chem. 2004 Sep 3; 279(36):37461-9. PMID: 15192107.
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    74. Hislop JN, Marley A, Von Zastrow M. Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes. J Biol Chem. 2004 May 21; 279(21):22522-31. PMID: 15024011.
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    75. von Zastrow M. Opioid receptor regulation. Neuromolecular Med. 2004; 5(1):51-8. PMID: 15001812.
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    76. von Zastrow M. A cell biologist's perspective on physiological adaptation to opiate drugs. Neuropharmacology. 2004; 47 Suppl 1:286-92. PMID: 15464144.
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    77. Tanowitz M, von Zastrow M. Identification of protein interactions by yeast two-hybrid screening and coimmunoprecipitation. Methods Mol Biol. 2004; 259:353-69. PMID: 15250504.
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    78. von Zastrow M. Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway. Life Sci. 2003 Dec 5; 74(2-3):217-24. PMID: 14607249.
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    79. Tanowitz M, von Zastrow M. A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors. J Biol Chem. 2003 Nov 14; 278(46):45978-86. PMID: 12939277.
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    80. Elenko E, Fischer T, Niesman I, Harding T, McQuistan T, Von Zastrow M, Farquhar MG. Spatial regulation of Galphai protein signaling in clathrin-coated membrane microdomains containing GAIP. Mol Pharmacol. 2003 Jul; 64(1):11-20. PMID: 12815156.
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    81. von Zastrow M, Svingos A, Haberstock-Debic H, Evans C. Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs. Curr Opin Neurobiol. 2003 Jun; 13(3):348-53. PMID: 12850220.
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    82. Haberstock-Debic H, Wein M, Barrot M, Colago EE, Rahman Z, Neve RL, Pickel VM, Nestler EJ, von Zastrow M, Svingos AL. Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons. J Neurosci. 2003 May 15; 23(10):4324-32. PMID: 12764121.
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    83. Kim KA, von Zastrow M. Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells. J Neurosci. 2003 Mar 15; 23(6):2075-85. PMID: 12657666.
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    84. Whistler JL, Gerber BO, Meng EC, Baranski TJ, von Zastrow M, Bourne HR. Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic. 2002 Dec; 3(12):866-77. PMID: 12453150.
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    85. Tanowitz M, Von Zastrow M. Ubiquitination-independent trafficking of G protein-coupled receptors to lysosomes. J Biol Chem. 2002 Dec 27; 277(52):50219-22. PMID: 12401797.
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    86. Xia H, von Zastrow M, Malenka RC. A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors. J Biol Chem. 2002 Dec 6; 277(49):47765-9. PMID: 12368290.
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    87. Sorkin A, Von Zastrow M. Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol. 2002 Aug; 3(8):600-14. PMID: 12154371.
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    88. Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M. Modulation of postendocytic sorting of G protein-coupled receptors. Science. 2002 Jul 26; 297(5581):615-20. PMID: 12142540.
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    89. Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, Williams JT. mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization. J Neurosci. 2002 Jul 1; 22(13):5769-76. PMID: 12097530.
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    90. Beattie EC, Stellwagen D, Morishita W, Bresnahan JC, Ha BK, Von Zastrow M, Beattie MS, Malenka RC. Control of synaptic strength by glial TNFalpha. Science. 2002 Mar 22; 295(5563):2282-5. PMID: 11910117.
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    91. He L, Fong J, von Zastrow M, Whistler JL. Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell. 2002 Jan 25; 108(2):271-82. PMID: 11832216.
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    92. Kim KA, von Zastrow M. Old drugs learn new tricks: insights from mammalian trace amine receptors. Mol Pharmacol. 2001 Dec; 60(6):1165-7. PMID: 11723221.
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    93. von Zastrow M, Mostov K. Signal transduction. A new thread in an intricate web. Science. 2001 Nov 30; 294(5548):1845-7. PMID: 11729293.
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    94. Gage RM, Kim KA, Cao TT, von Zastrow M. A transplantable sorting signal that is sufficient to mediate rapid recycling of G protein-coupled receptors. J Biol Chem. 2001 Nov 30; 276(48):44712-20. PMID: 11560936.
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    95. von Zastrow M. Role of endocytosis in signalling and regulation of G-protein-coupled receptors. Biochem Soc Trans. 2001 Aug; 29(Pt 4):500-4. PMID: 11498017.
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    96. Whistler JL, Tsao P, von Zastrow M. A phosphorylation-regulated brake mechanism controls the initial endocytosis of opioid receptors but is not required for post-endocytic sorting to lysosomes. J Biol Chem. 2001 Sep 7; 276(36):34331-8. PMID: 11443128.
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    97. Klein U, Müller C, Chu P, Birnbaumer M, von Zastrow M. Heterologous inhibition of G protein-coupled receptor endocytosis mediated by receptor-specific trafficking of beta-arrestins. J Biol Chem. 2001 May 18; 276(20):17442-7. PMID: 11278476.
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    98. Tsao PI, von Zastrow M. Diversity and specificity in the regulated endocytic membrane trafficking of G-protein-coupled receptors. Pharmacol Ther. 2001 Feb; 89(2):139-47. PMID: 11316517.
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    99. Tsao P, Cao T, von Zastrow M. Role of endocytosis in mediating downregulation of G-protein-coupled receptors. Trends Pharmacol Sci. 2001 Feb; 22(2):91-6. PMID: 11166853.
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    100. Beattie EC, Carroll RC, Yu X, Morishita W, Yasuda H, von Zastrow M, Malenka RC. Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci. 2000 Dec; 3(12):1291-300. PMID: 11100150.
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    101. Whistler J, Beattie E, von Zastrow M. Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway. Sci STKE. 2000 Aug 29; 2000(47):pe1. PMID: 11752604.
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    102. Tsao P, von Zastrow M. Downregulation of G protein-coupled receptors. Curr Opin Neurobiol. 2000 Jun; 10(3):365-9. PMID: 10851176.
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    103. Tsao PI, von Zastrow M. Type-specific sorting of G protein-coupled receptors after endocytosis. J Biol Chem. 2000 Apr 14; 275(15):11130-40. PMID: 10753919.
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    104. Carroll RC, Beattie EC, Xia H, Lüscher C, Altschuler Y, Nicoll RA, Malenka RC, von Zastrow M. Dynamin-dependent endocytosis of ionotropic glutamate receptors. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):14112-7. PMID: 10570207; PMCID: PMC24199.
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    105. Lüscher C, Xia H, Beattie EC, Carroll RC, von Zastrow M, Malenka RC, Nicoll RA. Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron. 1999 Nov; 24(3):649-58. PMID: 10595516.
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    106. Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature. 1999 Sep 16; 401(6750):286-90. PMID: 10499588.
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    107. Whistler JL, von Zastrow M. Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction. J Biol Chem. 1999 Aug 27; 274(35):24575-8. PMID: 10455121.
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    108. Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M. Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron. 1999 Aug; 23(4):737-46. PMID: 10482240.
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    109. Carroll RC, Lissin DV, von Zastrow M, Nicoll RA, Malenka RC. Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures. Nat Neurosci. 1999 May; 2(5):454-60. PMID: 10321250.
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    110. Lissin DV, Malenka RC, Von Zastrow M. An immunocytochemical assay for activity-dependent redistribution of glutamate receptors from the postsynaptic plasma membrane. Ann N Y Acad Sci. 1999 Apr 30; 868:550-3. PMID: 10414334.
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    111. Lissin DV, Carroll RC, Nicoll RA, Malenka RC, von Zastrow M. Rapid, activation-induced redistribution of ionotropic glutamate receptors in cultured hippocampal neurons. J Neurosci. 1999 Feb 15; 19(4):1263-72. PMID: 9952404.
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    112. Vickery RG, von Zastrow M. Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes. J Cell Biol. 1999 Jan 11; 144(1):31-43. PMID: 9885242; PMCID: PMC2148123.
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    113. Murray SR, Evans CJ, von Zastrow M. Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor. J Biol Chem. 1998 Sep 25; 273(39):24987-91. PMID: 9737953.
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    114. Cao TT, Mays RW, von Zastrow M. Regulated endocytosis of G-protein-coupled receptors by a biochemically and functionally distinct subpopulation of clathrin-coated pits. J Biol Chem. 1998 Sep 18; 273(38):24592-602. PMID: 9733754.
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    115. Whistler JL, von Zastrow M. Morphine-activated opioid receptors elude desensitization by beta-arrestin. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9914-9. PMID: 9707575; PMCID: PMC21436.
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    116. Lissin DV, Gomperts SN, Carroll RC, Christine CW, Kalman D, Kitamura M, Hardy S, Nicoll RA, Malenka RC, von Zastrow M. Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):7097-102. PMID: 9618545; PMCID: PMC22752.
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    117. Chu P, Murray S, Lissin D, von Zastrow M. Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J Biol Chem. 1997 Oct 24; 272(43):27124-30. PMID: 9341153.
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    118. Wedegaertner PB, Bourne HR, von Zastrow M. Activation-induced subcellular redistribution of Gs alpha. Mol Biol Cell. 1996 Aug; 7(8):1225-33. PMID: 8856666; PMCID: PMC275974.
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    119. Van Gelder RN, von Zastrow ME, Yool A, Dement WC, Barchas JD, Eberwine JH. Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proc Natl Acad Sci U S A. 1990 Mar; 87(5):1663-7. PMID: 1689846; PMCID: PMC53542.
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