Loading...

Ira Mellman, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Yale University School of Medicine, New Haven, CTPhDGenetics
    The Rockefeller University, New York, NYpostdocImmunology/Cell Biology
    Oberlin College, Oberlin, OHAB

    Collapse Research 
    Collapse Research Activities and Funding
    Cell Biology of the Immune Response
    NIH/NIAID R13AI053905Jan 15, 2003 - Dec 31, 2003
    Role: Principal Investigator
    GORDON RESEARCH CONFERENCE ON MOLECULAR MEMBRANE BIOLOGY
    NIH/NIGMS R13GM049679Jul 1, 1993 - Jun 30, 1994
    Role: Principal Investigator
    DEVELOPMENTAL CELL BIOLOGY OF DENDRITIC CELLS
    NIH/NIAID R37AI034098Mar 1, 1993 - Jul 31, 2008
    Role: Principal Investigator
    CELL BIOLOGY OF FC RECEPTOR FUNCTION
    NIH/NIAID R01AI034098Mar 1, 1993 - Feb 28, 1998
    Role: Principal Investigator
    CELL BIOLOGY OF MHC CLASS II ANTIGEN PRESENTATION
    NIH/NIGMS R01GM033904Jul 1, 1984 - Mar 31, 1999
    Role: Principal Investigator
    Molecular Sorting During Intracellular Transport
    NIH/NIGMS R01GM029765Jul 1, 1981 - Dec 30, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kong Y, Rose CM, Cass AA, Williams AG, Darwish M, Lianoglou S, Haverty PM, Tong AJ, Blanchette C, Albert ML, Mellman I, Bourgon R, Greally J, Jhunjhunwala S, Chen-Harris H. Transposable element expression in tumors is associated with immune infiltration and increased antigenicity. Nat Commun. 2019 Nov 19; 10(1):5228. PMID: 31745090.
      View in: PubMed
    2. Brand A, Diener N, Zahner SP, Tripp C, Backer RA, Karram K, Jiang A, Mellman I, Stoitzner P, Clausen BE. E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis. J Invest Dermatol. 2019 Jun 28. PMID: 31260672.
      View in: PubMed
    3. Xiong H, Mittman S, Rodriguez R, Pacheco-Sanchez P, Moskalenko M, Yang Y, Elstrott J, Ritter AT, Müller S, Nickles D, Arenzana TL, Capietto AH, Delamarre L, Modrusan Z, Rutz S, Mellman I, Cubas R. Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8+ T Cells in Murine Syngeneic Tumor Models. Cancer Immunol Res. 2019 Jun; 7(6):963-976. PMID: 31064777.
      View in: PubMed
    4. Moussion C, Mellman I. The Dendritic Cell Strikes Back. Immunity. 2019 02 19; 50(2):533. PMID: 30784580.
      View in: PubMed
    5. Moussion C, Mellman I. The Dendritic Cell Strikes Back. Immunity. 2018 12 18; 49(6):997-999. PMID: 30566889.
      View in: PubMed
    6. Lim YW, Chen-Harris H, Mayba O, Lianoglou S, Wuster A, Bhangale T, Khan Z, Mariathasan S, Daemen A, Reeder J, Haverty PM, Forrest WF, Brauer M, Mellman I, Albert ML. Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration. Proc Natl Acad Sci U S A. 2018 12 11; 115(50):E11701-E11710. PMID: 30463956.
      View in: PubMed
    7. Kowanetz M, Zou W, Gettinger SN, Koeppen H, Kockx M, Schmid P, Kadel EE, Wistuba I, Chaft J, Rizvi NA, Spigel DR, Spira A, Hirsch FR, Cohen V, Smith D, Boyd Z, Miley N, Flynn S, Leveque V, Shames DS, Ballinger M, Mocci S, Shankar G, Funke R, Hampton G, Sandler A, Amler L, Mellman I, Chen DS, Hegde PS. Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1). Proc Natl Acad Sci U S A. 2018 10 23; 115(43):E10119-E10126. PMID: 30297397.
      View in: PubMed
    8. Hernandez S, Qing J, Thibodeau RH, Du X, Park S, Lee HM, Xu M, Oh S, Navarro A, Roose-Girma M, Newman RJ, Warming S, Nannini M, Sampath D, Kim JM, Grogan JL, Mellman I. The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function. Cell Rep. 2018 10 02; 25(1):80-94. PMID: 30282040.
      View in: PubMed
    9. Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Senbabaoglu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T. TGFß attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature. 2018 02 22; 554(7693):544-548. PMID: 29443960.
      View in: PubMed
    10. Viotti M, Wilson C, McCleland M, Koeppen H, Haley B, Jhunjhunwala S, Klijn C, Modrusan Z, Arnott D, Classon M, Stephan JP, Mellman I. SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer. J Cell Biol. 2018 02 05; 217(2):763-777. PMID: 29229751.
      View in: PubMed
    11. Baharom F, Thomas OS, Lepzien R, Mellman I, Chalouni C, Smed-Sörensen A. Visualization of early influenza A virus trafficking in human dendritic cells using STED microscopy. PLoS One. 2017; 12(6):e0177920. PMID: 28591131.
      View in: PubMed
    12. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017 03 31; 355(6332):1428-1433. PMID: 28280247.
      View in: PubMed
    13. Lau J, Cheung J, Navarro A, Lianoglou S, Haley B, Totpal K, Sanders L, Koeppen H, Caplazi P, McBride J, Chiu H, Hong R, Grogan J, Javinal V, Yauch R, Irving B, Belvin M, Mellman I, Kim JM, Schmidt M. Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice. Nat Commun. 2017 02 21; 8:14572. PMID: 28220772.
      View in: PubMed
    14. Vander Lugt B, Riddell J, Khan AA, Hackney JA, Lesch J, DeVoss J, Weirauch MT, Singh H, Mellman I. Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation. J Cell Biol. 2017 03 06; 216(3):779-792. PMID: 28130292.
      View in: PubMed
    15. Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017 01 18; 541(7637):321-330. PMID: 28102259.
      View in: PubMed
    16. Ritter AT, Mellman I. Natural killer cell granules converge to avoid collateral damage. J Cell Biol. 2016 Dec 19; 215(6):765-767. PMID: 27932575.
      View in: PubMed
    17. Chung I, Reichelt M, Shao L, Akita RW, Koeppen H, Rangell L, Schaefer G, Mellman I, Sliwkowski MX. High cell-surface density of HER2 deforms cell membranes. Nat Commun. 2016 09 07; 7:12742. PMID: 27599456.
      View in: PubMed
    18. Kaufman HL, Butterfield LH, Coulie PG, Demaria S, Ferris RL, Galon J, Khleif SN, Mellman I, Ohashi PS, Overwijk WW, Topalian SL, Marincola FM. Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule. J Immunother Cancer. 2016; 4:37. PMID: 27330810.
      View in: PubMed
    19. Houot R, Gaulard P, Schreiber R, Mellman I, Lambotte O, Coulie PG, Fest T, Korman A, Levy R, Shipp M, Tarte K, Kohrt H, Marabelle A, Ansell S, Watier H, van Elsas A, Balakumaran A, Arce Vargas F, Quezada SA, Salles G, Olive D. Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop. Oncoimmunology. 2016 Jul; 5(7):e1186323. PMID: 27622041.
      View in: PubMed
    20. Romero P, Banchereau J, Bhardwaj N, Cockett M, Disis ML, Dranoff G, Gilboa E, Hammond SA, Hershberg R, Korman AJ, Kvistborg P, Melief C, Mellman I, Palucka AK, Redchenko I, Robins H, Sallusto F, Schenkelberg T, Schoenberger S, Sosman J, Türeci Ö, Van den Eynde B, Koff W, Coukos G. The Human Vaccines Project: A roadmap for cancer vaccine development. Sci Transl Med. 2016 Apr 13; 8(334):334ps9. PMID: 27075624.
      View in: PubMed
    21. Mellman I, Hubbard-Lucey VM, Tontonoz MJ, Kalos MD, Chen DS, Allison JP, Drake CG, Levitsky H, Lonberg N, van der Burg SH, Fearon DT, Wherry EJ, Lowy I, Vonderheide RH, Hwu P. De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute. Cancer Immunol Res. 2016 Apr; 4(4):279-88. PMID: 27036972.
      View in: PubMed
    22. Ebert PJR, Cheung J, Yang Y, McNamara E, Hong R, Moskalenko M, Gould SE, Maecker H, Irving BA, Kim JM, Belvin M, Mellman I. MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade. Immunity. 2016 Mar 15; 44(3):609-621. PMID: 26944201.
      View in: PubMed
    23. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T. Voices of biotech. Nat Biotechnol. 2016 Mar; 34(3):270-5. PMID: 26963549.
      View in: PubMed
    24. Belvin M, Mellman I. Is all cancer therapy immunotherapy? Sci Transl Med. 2015 Nov 25; 7(315):315fs48. PMID: 26606965.
      View in: PubMed
    25. Katakam AK, Brightbill H, Franci C, Kung C, Nunez V, Jones C, Peng I, Jeet S, Wu LC, Mellman I, Delamarre L, Austin CD. Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14664-9. PMID: 26561586.
      View in: PubMed
    26. Delamarre L, Mellman I, Yadav M. Cancer immunotherapy. Neo approaches to cancer vaccines. Science. 2015 May 15; 348(6236):760-1. PMID: 25977539.
      View in: PubMed
    27. Topalian SL, Wolchok JD, Chan TA, Mellman I, Palucka K, Banchereau J, Rosenberg SA, Dane Wittrup K. Immunotherapy: The path to win the war on cancer? Cell. 2015 Apr 09; 161(2):185-6. PMID: 26042237.
      View in: PubMed
    28. Baharom F, Thomas S, Bieder A, Hellmér M, Volz J, Sandgren KJ, McInerney GM, Karlsson Hedestam GB, Mellman I, Smed-Sörensen A. Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation. J Immunol. 2015 May 01; 194(9):4422-30. PMID: 25801434.
      View in: PubMed
    29. Fu C, Liang X, Cui W, Ober-Blöbaum JL, Vazzana J, Shrikant PA, Lee KP, Clausen BE, Mellman I, Jiang A. ß-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2823-8. PMID: 25730849.
      View in: PubMed
    30. Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM. Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse. Mol Biol Cell. 2015 Apr 01; 26(7):1273-85. PMID: 25631815.
      View in: PubMed
    31. Chung I, Mellman I. Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells. Methods Mol Biol. 2015; 1233:35-44. PMID: 25319887.
      View in: PubMed
    32. Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014 Nov 27; 515(7528):563-7. PMID: 25428504.
      View in: PubMed
    33. Yadav M, Jhunjhunwala S, Phung QT, Lupardus P, Tanguay J, Bumbaca S, Franci C, Cheung TK, Fritsche J, Weinschenk T, Modrusan Z, Mellman I, Lill JR, Delamarre L. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature. 2014 Nov 27; 515(7528):572-6. PMID: 25428506.
      View in: PubMed
    34. Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I. Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature. 2014 May 08; 509(7499):240-4. PMID: 24695226.
      View in: PubMed
    35. Vander Lugt B, Khan AA, Hackney JA, Agrawal S, Lesch J, Zhou M, Lee WP, Park S, Xu M, DeVoss J, Spooner CJ, Chalouni C, Delamarre L, Mellman I, Singh H. Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation. Nat Immunol. 2014 Feb; 15(2):161-7. PMID: 24362890.
      View in: PubMed
    36. Mellman I, Yarden Y. Endocytosis and cancer. Cold Spring Harb Perspect Biol. 2013 Dec 01; 5(12):a016949. PMID: 24296170.
      View in: PubMed
    37. Mellman I, Emr SD. A Nobel Prize for membrane traffic: vesicles find their journey's end. J Cell Biol. 2013 Nov 25; 203(4):559-61. PMID: 24215073.
      View in: PubMed
    38. Sliwkowski MX, Mellman I. Antibody therapeutics in cancer. Science. 2013 Sep 13; 341(6151):1192-8. PMID: 24031011.
      View in: PubMed
    39. Liang X, Fu C, Cui W, Ober-Blöbaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, Jiang A. ß-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8? T cells. J Leukoc Biol. 2014 Jan; 95(1):179-90. PMID: 24023259.
      View in: PubMed
    40. Mellman I. Dendritic cells: master regulators of the immune response. Cancer Immunol Res. 2013 Sep; 1(3):145-9. PMID: 24777676.
      View in: PubMed
    41. Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013 Jul 25; 39(1):1-10. PMID: 23890059.
      View in: PubMed
    42. Oh J, Wu N, Baravalle G, Cohn B, Ma J, Lo B, Mellman I, Ishido S, Anderson M, Shin JS. MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med. 2013 Jun 03; 210(6):1069-77. PMID: 23712430.
      View in: PubMed
    43. Cohn L, Chatterjee B, Esselborn F, Smed-Sörensen A, Nakamura N, Chalouni C, Lee BC, Vandlen R, Keler T, Lauer P, Brockstedt D, Mellman I, Delamarre L. Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation. J Exp Med. 2013 May 06; 210(5):1049-63. PMID: 23569326.
      View in: PubMed
    44. Lo B, Strasser G, Sagolla M, Austin CD, Junttila M, Mellman I. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J Cell Biol. 2012 Dec 24; 199(7):1117-30. PMID: 23266956.
      View in: PubMed
    45. Chatterjee B, Smed-Sörensen A, Cohn L, Chalouni C, Vandlen R, Lee BC, Widger J, Keler T, Delamarre L, Mellman I. Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells. Blood. 2012 Sep 06; 120(10):2011-20. PMID: 22791285.
      View in: PubMed
    46. Mellman I. Profile of Ira Mellman. Interview by Prashant Nair. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):8790-2. PMID: 22645337.
      View in: PubMed
    47. Ma JK, Platt MY, Eastham-Anderson J, Shin JS, Mellman I. MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):8820-7. PMID: 22566640.
      View in: PubMed
    48. Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W, Fang G. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5299-304. PMID: 22431598.
      View in: PubMed
    49. Smed-Sörensen A, Chalouni C, Chatterjee B, Cohn L, Blattmann P, Nakamura N, Delamarre L, Mellman I. Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells. PLoS Pathog. 2012; 8(3):e1002572. PMID: 22412374.
      View in: PubMed
    50. Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011 Dec 21; 480(7378):480-9. PMID: 22193102.
      View in: PubMed
    51. Banchereau J, Cohn F, Inaba K, Muller B, Mellman I, Nathan C, Nussenzweig M, O'Garra A, Seder B, Schuler G, Sher A. Remembering Ralph Steinman. J Exp Med. 2011 Nov 21; 208(12):2343-7. PMID: 22216461.
      View in: PubMed
    52. Mellman I, Nussenzweig M. Retrospective. Ralph M. Steinman (1943-2011). Science. 2011 Oct 28; 334(6055):466. PMID: 22034425.
      View in: PubMed
    53. Nussenzweig MC, Mellman I. Ralph Steinman (1943-2011). Nature. 2011 Oct 26; 478(7370):460. PMID: 22031432.
      View in: PubMed
    54. Francis SS, Sfakianos J, Lo B, Mellman I. A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells. J Cell Biol. 2011 Apr 04; 193(1):219-33. PMID: 21444686.
      View in: PubMed
    55. Zhang L, Jouret F, Rinehart J, Sfakianos J, Mellman I, Lifton RP, Young LH, Caplan MJ. AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3ß (GSK-3ß) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane. J Biol Chem. 2011 May 13; 286(19):16879-90. PMID: 21383016.
      View in: PubMed
    56. Delamarre L, Mellman I. Harnessing dendritic cells for immunotherapy. Semin Immunol. 2011 Feb; 23(1):2-11. PMID: 21377379.
      View in: PubMed
    57. Mellman I. Cell biology redux. Mol Biol Cell. 2010 Nov 15; 21(22):3809-10. PMID: 21079023.
      View in: PubMed
    58. Palucka K, Banchereau J, Mellman I. Designing vaccines based on biology of human dendritic cell subsets. Immunity. 2010 Oct 29; 33(4):464-78. PMID: 21029958.
      View in: PubMed
    59. Togawa A, Sfakianos J, Ishibe S, Suzuki S, Fujigaki Y, Kitagawa M, Mellman I, Cantley LG. Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly. Biochem Biophys Res Commun. 2010 Sep 17; 400(2):271-7. PMID: 20728428.
      View in: PubMed
    60. Mellman I, Clausen BE. Immunology. Beta-catenin balances immunity. Science. 2010 Aug 13; 329(5993):767-9. PMID: 20705838.
      View in: PubMed
    61. McCurley N, Mellman I. Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations. PLoS One. 2010 Aug 02; 5(8):e11949. PMID: 20689855.
      View in: PubMed
    62. Winckler B, Mellman I. Trafficking guidance receptors. Cold Spring Harb Perspect Biol. 2010 Jul; 2(7):a001826. PMID: 20504966.
      View in: PubMed
    63. Chung I, Akita R, Vandlen R, Toomre D, Schlessinger J, Mellman I. Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature. 2010 Apr 01; 464(7289):783-7. PMID: 20208517.
      View in: PubMed
    64. Mellman I, Cresswell P. Antigen processing and presentation. Curr Opin Immunol. 2010 Feb; 22(1):78-80. PMID: 20172702.
      View in: PubMed
    65. Platt CD, Ma JK, Chalouni C, Ebersold M, Bou-Reslan H, Carano RA, Mellman I, Delamarre L. Mature dendritic cells use endocytic receptors to capture and present antigens. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4287-92. PMID: 20142498.
      View in: PubMed
    66. Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010 Jan 19; 18(1):39-51. PMID: 20152176.
      View in: PubMed
    67. Cheever MA, Allison JP, Ferris AS, Finn OJ, Hastings BM, Hecht TT, Mellman I, Prindiville SA, Viner JL, Weiner LM, Matrisian LM. The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res. 2009 Sep 01; 15(17):5323-37. PMID: 19723653.
      View in: PubMed
    68. Farr GA, Hull M, Mellman I, Caplan MJ. Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. J Cell Biol. 2009 Jul 27; 186(2):269-82. PMID: 19620635.
      View in: PubMed
    69. Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine. 2009 May 18; 27(23):3013-21. PMID: 19428913.
      View in: PubMed
    70. Becker SM, Delamarre L, Mellman I, Andrews NW. Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells. Immunobiology. 2009; 214(7):495-505. PMID: 19157638.
      View in: PubMed
    71. Mao YS, Yamaga M, Zhu X, Wei Y, Sun HQ, Wang J, Yun M, Wang Y, Di Paolo G, Bennett M, Mellman I, Abrams CS, De Camilli P, Lu CY, Yin HL. Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis. J Cell Biol. 2009 Jan 26; 184(2):281-96. PMID: 19153220.
      View in: PubMed
    72. Goldszmid RS, Coppens I, Lev A, Caspar P, Mellman I, Sher A. Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. J Exp Med. 2009 Feb 16; 206(2):399-410. PMID: 19153244.
      View in: PubMed
    73. Mellman I. By the scientists, for the scientists. J Cell Biol. 2009 Jan 12; 184(1):7-9. PMID: 19139258.
      View in: PubMed
    74. Mellman I, Nelson WJ. Coordinated protein sorting, targeting and distribution in polarized cells. Nat Rev Mol Cell Biol. 2008 Nov; 9(11):833-45. PMID: 18946473.
      View in: PubMed
    75. Maday S, Anderson E, Chang HC, Shorter J, Satoh A, Sfakianos J, Fölsch H, Anderson JM, Walther Z, Mellman I. A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells. Traffic. 2008 Nov; 9(11):1915-24. PMID: 18764819.
      View in: PubMed
    76. Ackerman ME, Chalouni C, Schmidt MM, Raman VV, Ritter G, Old LJ, Mellman I, Wittrup KD. A33 antigen displays persistent surface expression. Cancer Immunol Immunother. 2008 Jul; 57(7):1017-27. PMID: 18236042.
      View in: PubMed
    77. Fahmy TM, Demento SL, Caplan MJ, Mellman I, Saltzman WM. Design opportunities for actively targeted nanoparticle vaccines. Nanomedicine (Lond). 2008 Jun; 3(3):343-55. PMID: 18510429.
      View in: PubMed
    78. Bloom O, Unternaehrer JJ, Jiang A, Shin JS, Delamarre L, Allen P, Mellman I. Spinophilin participates in information transfer at immunological synapses. J Cell Biol. 2008 Apr 21; 181(2):203-11. PMID: 18411312.
      View in: PubMed
    79. Di Pucchio T, Chatterjee B, Smed-Sörensen A, Clayton S, Palazzo A, Montes M, Xue Y, Mellman I, Banchereau J, Connolly JE. Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol. 2008 May; 9(5):551-7. PMID: 18376401.
      View in: PubMed
    80. Reig N, Jiang A, Couture R, Sutterwala FS, Ogura Y, Flavell RA, Mellman I, van der Goot FG. Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin. Cell Microbiol. 2008 May; 10(5):1190-207. PMID: 18194483.
      View in: PubMed
    81. Sfakianos J, Togawa A, Maday S, Hull M, Pypaert M, Cantley L, Toomre D, Mellman I. Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol. 2007 Dec 17; 179(6):1133-40. PMID: 18070914.
      View in: PubMed
    82. Perera RM, Zoncu R, Johns TG, Pypaert M, Lee FT, Mellman I, Old LJ, Toomre DK, Scott AM. Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody. Neoplasia. 2007 Dec; 9(12):1099-110. PMID: 18084617.
      View in: PubMed
    83. Jiang A, Bloom O, Ono S, Cui W, Unternaehrer J, Jiang S, Whitney JA, Connolly J, Banchereau J, Mellman I. Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity. 2007 Oct; 27(4):610-24. PMID: 17936032.
      View in: PubMed
    84. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schröder JM, Liu YJ, Gilliet M. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007 Oct 04; 449(7162):564-9. PMID: 17873860.
      View in: PubMed
    85. Mellman I. Private lives: reflections and challenges in understanding the cell biology of the immune system. Science. 2007 Aug 03; 317(5838):625-7. PMID: 17673653.
      View in: PubMed
    86. Rossner M, Mellman I. How the rich get richer. J Exp Med. 2007 Jul 09; 204(7):1503. PMID: 17576780.
      View in: PubMed
    87. Rossner M, Mellman I. How the rich get richer. J Cell Biol. 2007 Jun 18; 177(6):951. PMID: 17562793.
      View in: PubMed
    88. Mellman I. Ira Mellman: from endosomes to industry. Interview by William A Wells. J Cell Biol. 2007 May 21; 177(4):570-1. PMID: 17517958.
      View in: PubMed
    89. Mellman I. Incomplete screening? Nat Immunol. 2007 May; 8(5):473. PMID: 17440454.
      View in: PubMed
    90. Unternaehrer JJ, Chow A, Pypaert M, Inaba K, Mellman I. The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):234-9. PMID: 17190803.
      View in: PubMed
    91. Mellman I. Bringing science to cancer therapy. Yale J Biol Med. 2006 Dec; 79(3-4):177-8. PMID: 17940629.
      View in: PubMed
    92. Schuck S, Gerl MJ, Ang A, Manninen A, Keller P, Mellman I, Simons K. Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic. 2007 Jan; 8(1):47-60. PMID: 17132146.
      View in: PubMed
    93. Shin JS, Ebersold M, Pypaert M, Delamarre L, Hartley A, Mellman I. Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature. 2006 Nov 02; 444(7115):115-8. PMID: 17051151.
      View in: PubMed
    94. Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA. Modulation of cell adhesion and motility in the immune system by Myo1f. Science. 2006 Oct 06; 314(5796):136-9. PMID: 17023661.
      View in: PubMed
    95. Delamarre L, Couture R, Mellman I, Trombetta ES. Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. J Exp Med. 2006 Sep 04; 203(9):2049-55. PMID: 16908625.
      View in: PubMed
    96. Hua W, Sheff D, Toomre D, Mellman I. Vectorial insertion of apical and basolateral membrane proteins in polarized epithelial cells revealed by quantitative 3D live cell imaging. J Cell Biol. 2006 Mar 27; 172(7):1035-44. PMID: 16567501.
      View in: PubMed
    97. Shim JH, Xiao C, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S. CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol. 2006 Mar 27; 172(7):1045-56. PMID: 16567502.
      View in: PubMed
    98. Zwickey HL, Unternaehrer JJ, Mellman I. Presentation of self-antigens on MHC class II molecules during dendritic cell maturation. Int Immunol. 2006 Jan; 18(1):199-209. PMID: 16361313.
      View in: PubMed
    99. Touret N, Paroutis P, Terebiznik M, Harrison RE, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, Peters PJ, de Chastellier C, Mellman I, Grinstein S. Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. Cell. 2005 Oct 07; 123(1):157-70. PMID: 16213220.
      View in: PubMed
    100. Anderson E, Maday S, Sfakianos J, Hull M, Winckler B, Sheff D, Fölsch H, Mellman I. Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways. J Cell Biol. 2005 Aug 15; 170(4):595-605. PMID: 16087710.
      View in: PubMed
    101. Yan J, Wolff MJ, Unternaehrer J, Mellman I, Mamula MJ. Targeting antigen to CD19 on B cells efficiently activates T cells. Int Immunol. 2005 Jul; 17(7):869-77. PMID: 15967786.
      View in: PubMed
    102. Johns TG, Mellman I, Cartwright GA, Ritter G, Old LJ, Burgess AW, Scott AM. The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor. FASEB J. 2005 May; 19(7):780-2. PMID: 15774576.
      View in: PubMed
    103. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science. 2005 Mar 11; 307(5715):1630-4. PMID: 15761154.
      View in: PubMed
    104. Chow AY, Mellman I. Old lysosomes, new tricks: MHC II dynamics in DCs. Trends Immunol. 2005 Feb; 26(2):72-8. PMID: 15668121.
      View in: PubMed
    105. Trombetta ES, Mellman I. Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol. 2005; 23:975-1028. PMID: 15771591.
      View in: PubMed
    106. Mellman I. Antigen processing and presentation by dendritic cells: cell biological mechanisms. Adv Exp Med Biol. 2005; 560:63-7. PMID: 15932021.
      View in: PubMed
    107. Meyer zum Bueschenfelde CO, Unternaehrer J, Mellman I, Bottomly K. Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells. J Immunol. 2004 Nov 15; 173(10):6119-24. PMID: 15528348.
      View in: PubMed
    108. Ang AL, Taguchi T, Francis S, Fölsch H, Murrells LJ, Pypaert M, Warren G, Mellman I. Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. J Cell Biol. 2004 Nov 08; 167(3):531-43. PMID: 15534004.
      View in: PubMed
    109. Matsuo M, Nagata Y, Sato E, Atanackovic D, Valmori D, Chen YT, Ritter G, Mellman I, Old LJ, Gnjatic S. IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14467-72. PMID: 15383663.
      View in: PubMed
    110. Steinman RM, Mellman I. The JEM and the JCB: a synergistic partnership. J Cell Biol. 2004 Aug 30; 166(5):611. PMID: 15337771.
      View in: PubMed
    111. Steinman RM, Mellman I. Immunotherapy: bewitched, bothered, and bewildered no more. Science. 2004 Jul 09; 305(5681):197-200. PMID: 15247468.
      View in: PubMed
    112. Duffield A, Fölsch H, Mellman I, Caplan MJ. Sorting of H,K-ATPase beta-subunit in MDCK and LLC-PK cells is independent of mu 1B adaptin expression. Traffic. 2004 Jun; 5(6):449-61. PMID: 15117319.
      View in: PubMed
    113. Chang HC, Hull M, Mellman I. The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila. J Cell Biol. 2004 Mar 29; 164(7):1055-64. PMID: 15051737.
      View in: PubMed
    114. Yeaman C, Ayala MI, Wright JR, Bard F, Bossard C, Ang A, Maeda Y, Seufferlein T, Mellman I, Nelson WJ, Malhotra V. Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol. 2004 Feb; 6(2):106-12. PMID: 14743217.
      View in: PubMed
    115. Ang AL, Fölsch H, Koivisto UM, Pypaert M, Mellman I. The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells. J Cell Biol. 2003 Oct 27; 163(2):339-50. PMID: 14581456.
      View in: PubMed
    116. Fölsch H, Pypaert M, Maday S, Pelletier L, Mellman I. The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains. J Cell Biol. 2003 Oct 27; 163(2):351-62. PMID: 14581457.
      View in: PubMed
    117. Delamarre L, Holcombe H, Mellman I. Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J Exp Med. 2003 Jul 07; 198(1):111-22. PMID: 12835477.
      View in: PubMed
    118. Mellman I, Misteli T. Computational cell biology. J Cell Biol. 2003 May 12; 161(3):463-4. PMID: 12743098.
      View in: PubMed
    119. Trombetta ES, Ebersold M, Garrett W, Pypaert M, Mellman I. Activation of lysosomal function during dendritic cell maturation. Science. 2003 Feb 28; 299(5611):1400-3. PMID: 12610307.
      View in: PubMed
    120. Chang HC, Newmyer SL, Hull MJ, Ebersold M, Schmid SL, Mellman I. Hsc70 is required for endocytosis and clathrin function in Drosophila. J Cell Biol. 2002 Nov 11; 159(3):477-87. PMID: 12427870.
      View in: PubMed
    121. Holcombe H, Mellman I, Janeway CA, Bottomly K, Dittel BN. The immunosuppressive agent 15-deoxyspergualin functions by inhibiting cell cycle progression and cytokine production following naive T cell activation. J Immunol. 2002 Nov 01; 169(9):4982-9. PMID: 12391212.
      View in: PubMed
    122. Chow A, Toomre D, Garrett W, Mellman I. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature. 2002 Aug 29; 418(6901):988-94. PMID: 12198549.
      View in: PubMed
    123. Nagata Y, Ono S, Matsuo M, Gnjatic S, Valmori D, Ritter G, Garrett W, Old LJ, Mellman I. Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10629-34. PMID: 12138174.
      View in: PubMed
    124. Mellman I, Ridley A. Regulation and functional insights in cellular polarity, Madrid, Spain June 3-5, 2002. J Cell Biol. 2002 Jul 08; 158(1):12-6. PMID: 12141270.
      View in: PubMed
    125. Sugimoto H, Sugahara M, Fölsch H, Koide Y, Nakatsu F, Tanaka N, Nishimura T, Furukawa M, Mullins C, Nakamura N, Mellman I, Ohno H. Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells. Mol Biol Cell. 2002 Jul; 13(7):2374-82. PMID: 12134076.
      View in: PubMed
    126. Sheff D, Pelletier L, O'Connell CB, Warren G, Mellman I. Transferrin receptor recycling in the absence of perinuclear recycling endosomes. J Cell Biol. 2002 Mar 04; 156(5):797-804. PMID: 11877458.
      View in: PubMed
    127. Sheff DR, Kroschewski R, Mellman I. Actin dependence of polarized receptor recycling in Madin-Darby canine kidney cell endosomes. Mol Biol Cell. 2002 Jan; 13(1):262-75. PMID: 11809838.
      View in: PubMed
    128. Horwich AL, Fenton WA, Firgaira FA, Fox JE, Kolansky D, Mellman IS, Rosenberg LE. Expression of amplified DNA sequences for ornithine transcarbamylase in HeLa cells: arginine residues may be required for mitochondrial import of enzyme precursor. J Cell Biol. 1985 May; 100(5):1515-21. PMID: 3988798.
      View in: PubMed
    129. Mellman IS, Plutner H, Steinman RM, Unkeless JC, Cohn ZA. Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis. J Cell Biol. 1983 Mar; 96(3):887-95. PMID: 6833386.
      View in: PubMed
    130. Steinman RM, Mellman IS, Muller WA, Cohn ZA. Endocytosis and the recycling of plasma membrane. J Cell Biol. 1983 Jan; 96(1):1-27. PMID: 6298247.
      View in: PubMed
    131. Yoshie O, Mellman IS, Broeze RJ, Garcia-Blanco M, Lengyel P. Interferon action: effects of mouse alpha and beta interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309Cr.1. Cell Immunol. 1982 Oct; 73(1):128-40. PMID: 6185239.
      View in: PubMed
    132. Mellman IS. Endocytosis, membrane recycling and Fc receptor function. Ciba Found Symp. 1982; (92):35-58. PMID: 6924894.
      View in: PubMed
    133. Sennett C, Rosenberg LE, Mellman IS. Transmembrane transport of cobalamin in prokaryotic and eukaryotic cells. Annu Rev Biochem. 1981; 50:1053-86. PMID: 6267986.
      View in: PubMed
    134. Unkeless JC, Fleit H, Mellman IS. Structural Aspects and Heterogeneity of Immunoglobulin Fc Receptors. Adv Immunol. 1981; 31:247-70. PMID: 7032255.
      View in: PubMed
    135. Steinman RM, Nogueira N, Witmer MD, Tydings JD, Mellman IS. Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophages. J Exp Med. 1980 Nov 01; 152(5):1248-61. PMID: 6448907.
      View in: PubMed
    136. Mellman IS, Unkeless JC. Purificaton of a functional mouse Fc receptor through the use of a monoclonal antibody. J Exp Med. 1980 Oct 01; 152(4):1048-69. PMID: 6158545.
      View in: PubMed
    137. Mellman IS, Steinman RM, Unkeless JC, Cohn ZA. Selective iodination and polypeptide composition of pinocytic vesicles. J Cell Biol. 1980 Sep; 86(3):712-22. PMID: 7410475.
      View in: PubMed
    138. Youngdahl-Turner P, Mellman IS, Allen RH, Rosenberg LE. Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts. Exp Cell Res. 1979 Jan; 118(1):127-34. PMID: 759210.
      View in: PubMed
    139. Mellman IS, Lin PF, Ruddle FH, Rosenberg LE. Genetic control of cobalamin binding in normal and mutant cells: assignment of the gene for 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase to human chromosome 1. Proc Natl Acad Sci U S A. 1979 Jan; 76(1):405-9. PMID: 284356.
      View in: PubMed
    140. Willard HF, Mellman IS, Rosenberg LE. Genetic complementation among inherited deficiencies of methylmalonyl-CoA mutase activity: evidence for a new class of human cobalamin mutant. Am J Hum Genet. 1978 Jan; 30(1):1-13. PMID: 23678.
      View in: PubMed
    141. Mellman IS, Youngdahl-Turner P, Willard HF, Rosenberg LE. Intracellular binding of radioactive hydroxocobalamin to cobalamin-dependent apoenzymes in rat liver. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):916-20. PMID: 15258.
      View in: PubMed
    142. Miller DH, Mellman IS, Lamport DT, Miller M. The chemical composition of the cell wall of Chlamydomonas gymnogama and the concept of a plant cell wall protein. J Cell Biol. 1974 Nov; 63(2 Pt 1):420-9. PMID: 4607708.
      View in: PubMed
    Ira's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (655) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (8) people
    _
    Similar People
    People who share similar concepts with this person.
    See all (60) people
    _
    Same Department
    Search Department
    ↑