Martin Kampmann, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentInstitute for Neurodegenerative Diseases
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Marburg University, Marburg, GermanyVordiplom06/2000Human Biology
    Cambridge University, Cambridge, UKBA / MA06/2003Biochemistry
    The Rockefeller University, New York, NYPhD06/2009Cell Biology, Biophysics
    UCSF, San FranciscoPostdoctoral Fellow07/2015Systems Biology
    Collapse Awards and Honors
    Chan Zuckerberg Biohub2017Investigator Award
    Stand Up 2 Cancer2016  - 2019Innovative Research Grant
    NIH2015  - 2020New Innovator Award
    Paul G. Allen Family Foundation2015  - 2018Allen Distinguished Investigator Award
    NIH/NCI2014  - 2018Pathway to Independence Award (K99/R00)
    Program for Breakthrough Biomedical Research, UCSF2012Postdoctoral Fellowship
    Jane Coffin Childs Memorial Fund2010  - 2013Postdoctoral Fellowship
    The Rockefeller University2006David Rockefeller Fellowship
    Howard Hughes Medical Institute2003  - 2008Predoctoral Fellowship
    Magdalene College, Cambridge University2003Saunders Prize for Natural Sciences
    Magdalene College, Cambridge University2002Keilin Prize for Natural Sciences
    German National Merit Foundation (Studienstiftung)1999  - 2003Undergraduate Scholarship

    Collapse Overview 
    Collapse Overview
    The Kampmann lab develops and uses innovative technologies to understand cellular and molecular mechanisms of human diseases, and to discover new therapeutic strategies.

    A major focus of our research are diseases associated with protein misfolding, such as neurodegenerative diseases. We ask how cells maintain their proteins in a functional and balanced state. In human cells, this is accomplished by a network of over 1,000 different factors called the proteostasis network. Our goal is to understand how this network functions, and how it is challenged and rewired in disease states.

    Our functional genomics technology, which integrates CRISPR/Cas9-based control of gene function and large-scale genetic interaction maps, enables us to elucidate dynamic networks and to pinpoint nodes that are potential therapeutic targets. CRISPRi and CRISPRa genetic screens in cells derived from human induced pluripotent stem cells (hiPSCs) can reveal mechanisms of disease-associated genes and of selective vulnerability of specific cell types. We use biochemistry, biophysics and cell biology to "zoom in" on individual nodes of the network and to reveal their mechanism of action.

    Collapse Research 
    Collapse Research Activities and Funding
    Linking tau proteostasis with neuronal activity in FTD
    NIH/NINDS U54NS100717Sep 30, 2016 - Aug 31, 2021
    Role: Co-Investigator
    Rewiring of the human protein homeostasis network in normal and disease contexts
    NIH DP2GM119139Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator
    Stress response networks in cancer: systematic mapping and therapeutic potential
    NIH R00CA181494Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Stress response networks in cancer: systematic mapping and therapeutic potential
    NIH K99CA181494Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS. Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Sci Rep. 2018 Apr 23; 8(1):6382. PMID: 29686391.
      View in: PubMed
    2. Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT. Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nat Biotechnol. 2018 Feb; 36(2):170-178. PMID: 29334369.
      View in: PubMed
    3. Kampmann M. CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine. ACS Chem Biol. 2018 Feb 16; 13(2):406-416. PMID: 29035510.
      View in: PubMed
    4. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2017 Oct 05; 68(1):210-223.e6. PMID: 28985505.
      View in: PubMed
    5. Nagy T, Kampmann M. CRISPulator: a discrete simulation tool for pooled genetic screens. BMC Bioinformatics. 2017 Jul 21; 18(1):347. PMID: 28732459.
      View in: PubMed
    6. Kampmann M. Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells. Chem Commun (Camb). 2017 Jun 29; 53(53):7162-7167. PMID: 28487920.
      View in: PubMed
    7. Kampmann M. A CRISPR Approach to Neurodegenerative Diseases. Trends Mol Med. 2017 06; 23(6):483-485. PMID: 28478951.
      View in: PubMed
    8. Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA. Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia. Blood. 2017 06 01; 129(22):3000-3008. PMID: 28424165.
      View in: PubMed
    9. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. PMID: 27978436.
      View in: PubMed
    10. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 09 23; 5. PMID: 27661255.
      View in: PubMed
    11. Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nat Chem Biol. 2016 May; 12(5):361-6. PMID: 27018887; PMCID: PMC4836973.
    12. Anderson DJ, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, Wang J, Yao B, Valle E, Kiss von Soly S, Madriaga A, Soriano F, Menon MK, Wu ZY, Kampmann M, Chen Y, Weissman JS, Aftab BT, Yakes FM, Shawver L, Zhou HJ, Wustrow D, Rolfe M. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 2015 Nov 09; 28(5):653-665. PMID: 26555175; PMCID: PMC4941640.
    13. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015 Sep 01; 4:e08153. PMID: 26327694; PMCID: PMC4602331.
    14. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS. Next-generation libraries for robust RNA interference-based genome-wide screens. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3384-91. PMID: 26080438; PMCID: PMC4491794.
    15. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. PMID: 25875391; PMCID: PMC4426669.
    16. Kampmann M, Bassik MC, Weissman JS. Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2015 Apr; 10(4):643. PMID: 25811902.
      View in: PubMed
    17. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PMID: 25564440; PMCID: PMC4456214.
    18. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. PMID: 25307932; PMCID: PMC4253859.
    19. Gu S, Zhang Y, Jin L, Huang Y, Zhang F, Bassik MC, Kampmann M, Kay MA. Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Nucleic Acids Res. 2014 Oct 29; 42(19):12169-76. PMID: 25270879; PMCID: PMC4231738.
    20. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. PMID: 25262416; PMCID: PMC4201873.
    21. Kampmann M, Bassik MC, Weissman JS. Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2014 Aug; 9(8):1825-47. PMID: 24992097; PMCID: PMC4144868.
    22. Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. PMID: 24183972.
      View in: PubMed
    23. Kampmann M, Bassik MC, Weissman JS. Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2317-26. PMID: 23739767; PMCID: PMC3690882.
    24. Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013 Feb 14; 152(4):909-22. PMID: 23394947; PMCID: PMC3652613.
    25. Atkinson CE, Mattheyses AL, Kampmann M, Simon SM. Conserved spatial organization of FG domains in the nuclear pore complex. Biophys J. 2013 Jan 08; 104(1):37-50. PMID: 23332057; PMCID: PMC3540264.
    26. Bassik MC, Kampmann M. Knocking out the door to tunicamycin entry. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11731-2. PMID: 21734150; PMCID: PMC3141928.
    27. Kampmann M, Atkinson CE, Mattheyses AL, Simon SM. Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy. Nat Struct Mol Biol. 2011 Jun; 18(6):643-9. PMID: 21499242; PMCID: PMC3109191.
    28. Mattheyses AL, Kampmann M, Atkinson CE, Simon SM. Fluorescence anisotropy reveals order and disorder of protein domains in the nuclear pore complex. Biophys J. 2010 Sep 22; 99(6):1706-17. PMID: 20858414; PMCID: PMC2941012.
    29. Leung AK, Kambach C, Kondo Y, Kampmann M, Jinek M, Nagai K. Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain. J Mol Biol. 2010 Sep 10; 402(1):154-64. PMID: 20643141.
      View in: PubMed
    30. Kampmann M, Blobel G. Biochemistry. Nascent proteins caught in the act. Science. 2009 Dec 04; 326(5958):1352-3. PMID: 19965743.
      View in: PubMed
    31. Nagy V, Hsia KC, Debler EW, Kampmann M, Davenport AM, Blobel G, Hoelz A. Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17693-8. PMID: 19805193; PMCID: PMC2764879.
    32. Kampmann M, Blobel G. Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex. Nat Struct Mol Biol. 2009 Jul; 16(7):782-8. PMID: 19503077; PMCID: PMC2706296.
    33. Kampmann M. Facilitated diffusion in chromatin lattices: mechanistic diversity and regulatory potential. Mol Microbiol. 2005 Aug; 57(4):889-99. PMID: 16091032.
      View in: PubMed
    34. Kampmann M, Stock D. Reverse gyrase has heat-protective DNA chaperone activity independent of supercoiling. Nucleic Acids Res. 2004; 32(12):3537-45. PMID: 15247343; PMCID: PMC484171.
    35. Kampmann M. Obstacle bypass in protein motion along DNA by two-dimensional rather than one-dimensional sliding. J Biol Chem. 2004 Sep 10; 279(37):38715-20. PMID: 15234977.
      View in: PubMed