Martin Kampmann, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #311A
San Francisco CA 94158
Phone415-514-5545
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-3819-7019 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Marburg University, Marburg, GermanyVordiplom06/2000Human Biology
    Cambridge University, Cambridge, UKBA / MA06/2003Biochemistry
    The Rockefeller University, New York, NYPhD06/2009Cell Biology, Biophysics
    UCSF, San FranciscoPostdoctoral Fellow07/2015Systems Biology
    Collapse Awards and Honors
    Rainwater Charitable Foundation2022Rainwater Prize for Innovative Early Career Scientist
    Allen Institute2020Cell Science Junior Fellow
    UCSF Biomedical Sciences Program2019Excellence in Graduate Student Mentoring Award
    Chan Zuckerberg Initiative2018Ben Barres Early Career Acceleration Award
    Chan Zuckerberg Biohub2017Investigator Award
    Stand Up 2 Cancer2016  - 2019Innovative Research Grant
    NIH2015  - 2020New Innovator Award
    Paul G. Allen Family Foundation2015  - 2018Allen Distinguished Investigator Award
    NIH/NCI2014  - 2018Pathway to Independence Award (K99/R00)
    Program for Breakthrough Biomedical Research, UCSF2012Postdoctoral Fellowship
    Jane Coffin Childs Memorial Fund2010  - 2013Postdoctoral Fellowship
    The Rockefeller University2006David Rockefeller Fellowship
    Howard Hughes Medical Institute2003  - 2008Predoctoral Fellowship
    Magdalene College, Cambridge University2003Saunders Prize for Natural Sciences
    Magdalene College, Cambridge University2002Keilin Prize for Natural Sciences
    German National Merit Foundation (Studienstiftung)1999  - 2003Undergraduate Scholarship

    Collapse Overview 
    Collapse Overview
    The Kampmann lab develops and applies innovative technologies to understand cellular and molecular mechanisms of aging-associated neurodegenerative diseases, and to discover new therapeutic strategies. A major focus of our research are Alzheimer's disease and related dementias.

    We have pioneered a CRISPR-based functional genomics platform in human iPSC-derived neurons, glia and 3D assembloids, which enables genome-wide modifier screens of disease-relevant cell biology in patient-derived cells. We have also developed cell-type specific CRISPR screening approaches for mouse models of disease.

    We use biochemistry, biophysics and cell biology to test mechanistic hypotheses generated by our functional genomics platform.

    Major research questions are:

    What controls protein aggregation in neurons, and why is it toxic? Why are some neuronal subtypes selectively vulnerable? Our main focus here is on the protein tau.

    How do non-neuronal cells such as microglia and astrocytes contribute to disease? What controls their beneficial and toxic states and functions in disease?

    Collapse Research 
    Collapse Research Activities and Funding
    Uncovering the genetic mechanisms of the Chromosome 17q21.31 Tau haplotype on neurodegeneration risk in FTD and PSP
    NIH U54NS123746Sep 1, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular Interactions
    NIH U01AG072464Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Systematic elucidation of endosomal trafficking as a therapeutic opportunity in AD using CRISPR-based functional genomics
    NIH R01AG062359Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    Uncovering mechanisms of selective vulnerability by CRISPR-based genetic screens
    NIH R56AG057528Sep 30, 2018 - Jun 30, 2020
    Role: Principal Investigator
    The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes
    NIH U01MH115747Sep 5, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Linking tau proteostasis with neuronal activity in FTD
    NIH U54NS100717Sep 30, 2016 - Aug 31, 2021
    Role: Co-Investigator
    Rewiring of the human protein homeostasis network in normal and disease contexts
    NIH DP2GM119139Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator
    Stress response networks in cancer: systematic mapping and therapeutic potential
    NIH R00CA181494Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Stress response networks in cancer: systematic mapping and therapeutic potential
    NIH K99CA181494Aug 1, 2014 - Jul 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Academic Senate

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes. Nat Biomed Eng. 2024 Dec 04. Yin JA, Frick L, Scheidmann MC, Liu T, Trevisan C, Dhingra A, Spinelli A, Wu Y, Yao L, Vena DL, Knapp B, Guo J, De Cecco E, Ging K, Armani A, Oakeley EJ, Nigsch F, Jenzer J, Haegele J, Pikusa M, Täger J, Rodriguez-Nieto S, Bouris V, Ribeiro R, Baroni F, Bedi MS, Berry S, Losa M, Hornemann S, Kampmann M, Pelkmans L, Hoepfner D, Heutink P, Aguzzi A. PMID: 39633028.
      View in: PubMed   Mentions:    Fields:    
    2. Implementation and validation of single-cell genomics experiments in neuroscience. Nat Neurosci. 2024 Dec; 27(12):2310-2325. Colonna M, Konopka G, Liddelow SA, Nowakowski T, Awatramani R, Bateup HS, Cadwell CR, Caglayan E, Chen JL, Gillis J, Kampmann M, Krienen F, Marsh SE, Monje M, O'Dea MR, Patani R, Pollen AA, Quintana FJ, Scavuzzo M, Schmitz M, Sloan SA, Tesar PJ, Tollkuhn J, Tosches MA, Urbanek ME, Werner JM, Bayraktar OA, Gokce O, Habib N. PMID: 39627589.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions. bioRxiv. 2024 Nov 24. Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Martinez D, Draeger N, Teter OM, Samelson AJ, Pierce N, Ullian EM, Kampmann M. PMID: 37163077; PMCID: PMC10168378.
      View in: PubMed   Mentions:
    4. CRISPRi-based screen of Autism Spectrum Disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning. bioRxiv. 2024 Nov 17. Teter OM, McQuade A, Hagan V, Liang W, Dräger NM, Sattler SM, Holmes BB, Castillo VC, Papakis V, Leng K, Boggess S, Nowakowski TJ, Wells J, Kampmann M. PMID: 39605704; PMCID: PMC11601228.
      View in: PubMed   Mentions:
    5. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv. 2024 Nov 04. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, Eisenberg D, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. PMID: 37398204; PMCID: PMC10312804.
      View in: PubMed   Mentions: 1  
    6. CRISPR screening by AAV episome-sequencing (CrAAVe-seq) is a highly scalable cell type-specific in vivo screening platform. bioRxiv. 2024 Oct 27. Ramani B, Rose IVL, Teyssier N, Pan A, Danner-Bocks S, Sanghal T, Yadanar L, Tian R, Ma K, Palop JJ, Kampmann M. PMID: 37398301; PMCID: PMC10312723.
      View in: PubMed   Mentions:
    7. pyPAGE: A framework for Addressing biases in gene-set enrichment analysis-A case study on Alzheimer's disease. PLoS Comput Biol. 2024 Sep; 20(9):e1012346. Bakulin A, Teyssier NB, Kampmann M, Khoroshkin M, Goodarzi H. PMID: 39236079; PMCID: PMC11421795.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation. Nat Chem Biol. 2024 Sep 02. Novy B, Dagunts A, Weishaar T, Holland EE, Adoff H, Hutchinson E, De Maria M, Kampmann M, Tsvetanova NG, Lobingier BT. PMID: 39223388.
      View in: PubMed   Mentions:    Fields:    
    9. mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes. J Neuroinflammation. 2024 Aug 08; 21(1):198. Leng K, Rooney B, McCarthy F, Xia W, Rose IVL, Bax S, Chin M, Fathi S, Herrington KA, Leonetti M, Kao A, Fancy SPJ, Elias JE, Kampmann M. PMID: 39118084; PMCID: PMC11312292.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4. bioRxiv. 2024 Jul 03. Feringa FM, Hertog SJK, Wang L, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward M, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R. PMID: 39005258; PMCID: PMC11244892.
      View in: PubMed   Mentions:
    11. Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes. bioRxiv. 2024 Jun 26. Ramadoss GN, Namaganda SJ, Hamilton JR, Sharma R, Chow KG, Macklin BL, Sun M, Liu JC, Fellmann C, Watry HL, Jin J, Perez BS, Sandoval Espinoza CR, Matia MP, Lu SH, Judge LM, Nussenzweig A, Adamson B, Murthy N, Doudna JA, Kampmann M, Conklin BR. PMID: 38979269; PMCID: PMC11230251.
      View in: PubMed   Mentions:
    12. The disease-causing tau V337M mutation induces tau hypophosphorylation and perturbs axon morphology pathways. bioRxiv. 2024 Jun 06. Mohl GA, Dixon G, Marzette E, McKetney J, Samelson AJ, Serras CP, Jin J, Li A, Boggess SC, Swaney DL, Kampmann M. PMID: 38895329; PMCID: PMC11185762.
      View in: PubMed   Mentions:
    13. Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma. . 2024 Jun 1; 100025. Choudhry CP, Kasap KC, Patiño-Escobar PB, Gugliemini GO, Geng GH, Sarin SV, Kang KA, Kishishita KA, Rampersaud RS, Sarah SL, Lin LY, Paranjape PN, Ramkumar RP, Patton PJ, Marcoulis MM, Wang WD, Phojanakong PP, Steri SV, Hann HB, Barwick BB, Kampmann KM, Wiita WA. .
      View in: Publisher Site   Mentions:
    14. Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proc Natl Acad Sci U S A. 2024 May 28; 121(22):e2315690121. Rose K, Jepson T, Shukla S, Maya-Romero A, Kampmann M, Xu K, Hurley JH. PMID: 38781206; PMCID: PMC11145263.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. B Cell-mediated Neurotoxicity in Multiple Sclerosis (P7-6.003). Neurology. 2024 Apr 9; 102(17_supplement_1). Saha SC, Zhang ZA, Leng LK, Gerungan GC, Abdelhak AA, Gomez GR, Harms HM, Tubati TA, Cooper CT, Louine LM, Sabatino SJ, Kampmann KM, Green GA, Oksenberg OJ, Cree CB, Wilson WM, Hauser HS. .
      View in: Publisher Site   Mentions:
    16. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. Cell. 2024 May 09; 187(10):2446-2464.e22. Parra Bravo C, Giani AM, Madero-Perez J, Zhao Z, Wan Y, Samelson AJ, Wong MY, Evangelisti A, Cordes E, Fan L, Ye P, Zhu D, Pozner T, Mercedes M, Patel T, Yarahmady A, Carling GK, Sterky FH, Lee VMY, Lee EB, DeTure M, Dickson DW, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L. PMID: 38582079; PMCID: PMC11365117.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases. Nat Rev Neurosci. 2024 May; 25(5):351-371. Kampmann M. PMID: 38575768.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    18. International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy. 2024 06; 20(6):1213-1246. Chen X, Tsvetkov AS, Shen HM, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon HU, Galluzzi L, Luo S, Xu D, Gu W, Peulen O, Cai Q, Rubinsztein DC, Chi JT, Zhang DD, Li C, Toyokuni S, Liu J, Roh JL, Dai E, Juhasz G, Liu W, Zhang J, Yang M, Liu J, Zhu LQ, Zou W, Piacentini M, Ding WX, Yue Z, Xie Y, Petersen M, Gewirtz DA, Mandell MA, Chu CT, Sinha D, Eftekharpour E, Zhivotovsky B, Besteiro S, Gabrilovich DI, Kim DH, Kagan VE, Bayir H, Chen GC, Ayton S, Lünemann JD, Komatsu M, Krautwald S, Loos B, Baehrecke EH, Wang J, Lane JD, Sadoshima J, Yang WS, Gao M, Münz C, Thumm M, Kampmann M, Yu D, Lipinski MM, Jones JW, Jiang X, Zeh HJ, Kang R, Klionsky DJ, Kroemer G, Tang D. PMID: 38442890; PMCID: PMC11210914.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    19. Autism genes converge on microtubule biology and RNA-binding proteins during excitatory neurogenesis. bioRxiv. 2024 Jan 02. Sun N, Teyssier N, Wang B, Drake S, Seyler M, Zaltsman Y, Everitt A, Teerikorpi N, Willsey HR, Goodarzi H, Tian R, Kampmann M, Willsey AJ. PMID: 38187634; PMCID: PMC10769323.
      View in: PubMed   Mentions:
    20. Phospholipase D3 drives microglial response to amyloid pathology in Alzheimer’s disease. Alzheimer's & Dementia. 2023 Dec 25; 19(S13). Rosene RM, Danhash DE, You YS, Iyer IA, Hsu HS, de Sa Lopes dM, Brase BL, Verbeck VA, Martinez MR, Wallace WC, Li LZ, Yan YP, Drager DN, Sattler SS, Mahan MT, Macauley MS, Holtzman HD, Benitez BB, Kampmann KM, Cruchaga CC, Harari HO, Cirrito CJ, Lee LJ, Goate GA, Karch KC. .
      View in: Publisher Site   Mentions:
    21. Multiomics of iPSC-derived ApoE3- and ApoE4 astrocytes and microglia uncovers cell type specific dysregulation of immunometabolism. Alzheimer's & Dementia. 2023 Dec 25; 19(S13). van der Kant vR, Blomberg BN, Erlebach EL, Feringa FF, Heijneman HJ, Koppes KS, Kruijff KI, McQuade MA, Miramontes MR, Olivier-Jimenez OD, Robert RA, Thompson TL, Ori OA, Kronenberg-Versteeg KD, Mohammed MY, Kampmann KM, Giera GM. .
      View in: Publisher Site   Mentions:
    22. Alzheimer’s disease risk genes modulate interferon-responsive microglia. Alzheimer's & Dementia. 2023 Dec 25; 19(S13). McQuade MA, Castillo CV, Drager DN, Kampmann KM. .
      View in: Publisher Site   Mentions:
    23. Toward a CRISPR understanding of gene function in human brain development. Cell Stem Cell. 2023 12 07; 30(12):1561-1562. Li E, Kampmann M. PMID: 38065064.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells. Cell Chem Biol. 2023 12 21; 30(12):1571-1584.e5. Perea V, Baron KR, Dolina V, Aviles G, Kim G, Rosarda JD, Guo X, Kampmann M, Wiseman RL. PMID: 37922906; PMCID: PMC10842031.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Neurodegeneration enters the era of functional genomics. Science. 2023 09 08; 381(6662):eadk5693. Aguzzi A, Kampmann M. PMID: 37676963.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. bioRxiv. 2023 Aug 28. Rose K, Jepson T, Shukla S, Maya-Romero A, Kampmann M, Xu K, Hurley JH. PMID: 37693477; PMCID: PMC10491128.
      View in: PubMed   Mentions:
    27. DELE1 oligomerization promotes integrated stress response activation. Nat Struct Mol Biol. 2023 09; 30(9):1295-1302. Yang J, Baron KR, Pride DE, Schneemann A, Guo X, Chen W, Song AS, Aviles G, Kampmann M, Wiseman RL, Lander GC. PMID: 37550454; PMCID: PMC10528447.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation. Dev Cell. 2023 09 25; 58(18):1782-1800.e10. Roberts MA, Deol KK, Mathiowetz AJ, Lange M, Leto DE, Stevenson J, Hashemi SH, Morgens DW, Easter E, Heydari K, Nalls MA, Bassik MC, Kampmann M, Kopito RR, Faghri F, Olzmann JA. PMID: 37494933; PMCID: PMC10530302.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    29. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. bioRxiv. 2023 Jun 22. Bravo CP, Giani AM, Perez JM, Zhao Z, Samelson A, Wong MY, Evangelisti A, Fan L, Pozner T, Mercedes M, Ye P, Patel T, Yarahmady A, Carling G, Lee VMY, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L. PMID: 37745431; PMCID: PMC10516028.
      View in: PubMed   Mentions:
    30. Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells. bioRxiv. 2023 May 17. Perea V, Baron KR, Dolina V, Aviles G, Rosarda JD, Guo X, Kampmann M, Wiseman RL. PMID: 36945406; PMCID: PMC10029010.
      View in: PubMed   Mentions:
    31. Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles. Nat Commun. 2023 05 10; 14(1):2698. Lan Y, van Leur SW, Fernando JA, Wong HH, Kampmann M, Siu L, Zhang J, Li M, Nicholls JM, Sanyal S. PMID: 37164963; PMCID: PMC10171163.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    32. Neurons require glucose uptake and glycolysis in vivo. Cell Rep. 2023 04 25; 42(4):112335. Li H, Guglielmetti C, Sei YJ, Zilberter M, Le Page LM, Shields L, Yang J, Nguyen K, Tiret B, Gao X, Bennett N, Lo I, Dayton TL, Kampmann M, Huang Y, Rathmell JC, Vander Heiden M, Chaumeil MM, Nakamura K. PMID: 37027294; PMCID: PMC10556202.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    33. A molecular glue approach to control the half-life of CRISPR-based technologies. bioRxiv. 2023 Mar 20. Sreekanth V, Jan M, Zhao KT, Lim D, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann M, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A. PMID: 36945568; PMCID: PMC10028966.
      View in: PubMed   Mentions:
    34. Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology. Stem Cell Reports. 2023 03 14; 18(3):706-719. de Majo M, Koontz M, Marsan E, Salinas N, Ramsey A, Kuo YM, Seo K, Li H, Dräger N, Leng K, Gonzales SL, Kurnellas M, Miyaoka Y, Klim JR, Kampmann M, Ward ME, Huang EJ, Ullian EM. PMID: 36827976; PMCID: PMC10031303.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    35. Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains. Cell Rep. 2023 02 28; 42(2):112110. Rheinberger M, Costa AL, Kampmann M, Glavas D, Shytaj IL, Sreeram S, Penzo C, Tibroni N, Garcia-Mesa Y, Leskov K, Fackler OT, Vlahovicek K, Karn J, Lucic B, Herrmann C, Lusic M. PMID: 36790927.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    36. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv. 2023 Feb 08. You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D'Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, Perrin RJ, McDade E, Dominantly Inherited Alzheimer Network, Paul SM, Cashikar AG, Benitez BA, Harari O, Karch CM. PMID: 36798226; PMCID: PMC9934804.
      View in: PubMed   Mentions:
    37. An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell. 2023 01 19; 186(2):346-362.e17. Oltion K, Carelli JD, Yang T, See SK, Wang HY, Kampmann M, Taunton J. PMID: 36638793; PMCID: PMC9994462.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    38. Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. Elife. 2022 12 28; 11. Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M. PMID: 36576240; PMCID: PMC9829409.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    39. Pathological Validation of RORB and CDH9 as Selectively Vulnerable Neurons in Alzheimer’s Disease. Alzheimer's & Dementia. 2022 Dec 20; 18(S3). Nasar NR, Pereira PF, Li LS, Miramontes MS, Kampmann KM, Leng LK, Seeley SW, Spina SS, Miller MB, Grinberg GL. .
      View in: Publisher Site   Mentions:
    40. A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 2022 12 01; 29(12):1685-1702.e22. Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Öttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, Schüle B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT. PMID: 36459969; PMCID: PMC9782786.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    41. Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics. Genome Med. 2022 11 18; 14(1):130. Leng K, Kampmann M. PMID: 36401300; PMCID: PMC9673433.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Nat Commun. 2022 11 02; 13(1):6581. Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. PMID: 36323693; PMCID: PMC9630454.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    43. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022 11; 25(11):1528-1542. Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. PMID: 36303069; PMCID: PMC9633461.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    44. Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion. Aging Cell. 2022 10; 21(10):e13713. Krause GJ, Diaz A, Jafari M, Khawaja RR, Agullo-Pascual E, Santiago-Fernández O, Richards AL, Chen KH, Dmitriev P, Sun Y, See SK, Abdelmohsen K, Mazan-Mamczarz K, Krogan NJ, Gorospe M, Swaney DL, Sidoli S, Bravo-Cordero JJ, Kampmann M, Cuervo AM. PMID: 36116133; PMCID: PMC9577956.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    45. Functional regulatory variants implicate distinct transcriptional networks in dementia. Science. 2022 08 19; 377(6608):eabi8654. Cooper YA, Teyssier N, Dräger NM, Guo Q, Davis JE, Sattler SM, Yang Z, Patel A, Wu S, Kosuri S, Coppola G, Kampmann M, Geschwind DH. PMID: 35981026.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    46. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nat Neurosci. 2022 09; 25(9):1149-1162. Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M. PMID: 35953545; PMCID: PMC9448678.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    47. Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model. ACS Chem Neurosci. 2022 05 18; 13(10):1505-1516. Chin MY, Ang KH, Davies J, Alquezar C, Garda VG, Rooney B, Leng K, Kampmann M, Arkin MR, Kao AW. PMID: 35522480; PMCID: PMC9121341.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    48. Conversations with LGBT+ scientists about visibility, leadership and climbing the career ladder. J Cell Sci. 2022 02 15; 135(4). Bristow RG, Engel J, Jayasinghe I, Kampmann M, James Sansom O, Bryant DM. PMID: 35188214.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    49. Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer. Cell Chem Biol. 2022 03 17; 29(3):490-501.e4. Shkedi A, Taylor IR, Echtenkamp F, Ramkumar P, Alshalalfa M, Rivera-Márquez GM, Moses MA, Shao H, Karnes RJ, Neckers L, Feng F, Kampmann M, Gestwicki JE. PMID: 35108506; PMCID: PMC8934263.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    50. NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Mol Cell. 2022 02 03; 82(3):555-569.e7. Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, Kampmann M, Lamb DC, Rosenzweig R, Sattler M, Buchner J. PMID: 35063133.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    51. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. Nat Cell Biol. 2022 01; 24(1):24-34. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 35027731; PMCID: PMC8820466.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    52. Evaluation of a nasopharyngeal stent in patients with obstructive sleep-related breathing disorders. J Int Med Res. 2022 Jan; 50(1):3000605211073302. Dellweg A, Kampmann M, Tschopp K. PMID: 35062854; PMCID: PMC8796092.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    53. CRISPR-Based Screening for Stress Response Factors in Mammalian Cells. Methods Mol Biol. 2022; 2428:19-40. Guo X, Kampmann M. PMID: 35171471.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    54. The Lonafarnib target, Rhes, is uniquely dysregulated in tauopathies: A human postmortem study. Alzheimer's & Dementia. 2021 Dec 31; 17(S5). Ehrenberg EA, Leng LK, Hernandez HI, Lew LC, Seeley SW, Spina SS, Miller MB, Heinsen HH, Kampmann KM, Kosik KK. .
      View in: Publisher Site   Mentions:
    55. Functional Multi-Omics Reveals Genetic and Pharmacologic Regulation of Surface CD38 in Multiple Myeloma. Blood. 2021 Nov 5; 138(Supplement 1):2648-2648. Choudhry CP, Gugliemini GO, Geng GH, Sarin SV, Sarah SL, Lin LY, Paranjape PN, Ramkumar RP, Marcoulis MM, Wang WD, Phojanakong PP, Steri SV, Hann HB, Kampmann KM, Wiita WA. .
      View in: Publisher Site   Mentions:
    56. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. bioRxiv. 2021 Sep 20. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 33501440; PMCID: PMC7836110.
      View in: PubMed   Mentions:
    57. Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells. Elife. 2021 05 26; 10. Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J. PMID: 34034859; PMCID: PMC8154037.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    58. Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. Nat Neurosci. 2021 07; 24(7):1020-1034. Tian R, Abarientos A, Hong J, Hashemi SH, Yan R, Dräger N, Leng K, Nalls MA, Singleton AB, Xu K, Faghri F, Kampmann M. PMID: 34031600; PMCID: PMC8254803.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansCells
    59. A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. The FASEB Journal. 2021 May 14; 35(S1). Semesta SK, Tian TR, Kampmann KM, Zastrow ZM, Tsvetanova TN. .
      View in: Publisher Site   Mentions:
    60. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 2021 04 29; 184(9):2503-2519.e17. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. PMID: 33838111; PMCID: PMC8376083.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansCells
    61. Patterns of neuronal Rhes as a novel hallmark of tauopathies. Acta Neuropathol. 2021 05; 141(5):651-666. Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. PMID: 33677647; PMCID: PMC8418783.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    62. Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability. Cell Stress Chaperones. 2021 03; 26(2):443-452. Abrams J, Arhar T, Mok SA, Taylor IR, Kampmann M, Gestwicki JE. PMID: 33547632; PMCID: PMC7925731.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    63. Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. J Cell Biol. 2021 02 01; 220(2). Kanfer G, Sarraf SA, Maman Y, Baldwin H, Dominguez-Martin E, Johnson KR, Ward ME, Kampmann M, Lippincott-Schwartz J, Youle RJ. PMID: 33464298; PMCID: PMC7816647.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    64. Molecular characterization of selectively vulnerable neurons in Alzheimer's disease. Nat Neurosci. 2021 02; 24(2):276-287. Leng K, Li E, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M. PMID: 33432193; PMCID: PMC7854528.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansCells
    65. A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. PLoS Genet. 2020 10; 16(10):e1009103. Semesta KM, Tian R, Kampmann M, von Zastrow M, Tsvetanova NG. PMID: 33052901; PMCID: PMC7588078.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    66. Defining the ATPome reveals cross-optimization of metabolic pathways. Nat Commun. 2020 08 28; 11(1):4319. Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. PMID: 32859923; PMCID: PMC7455733.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    67. Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. ACS Chem Biol. 2020 08 21; 15(8):2137-2153. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M. PMID: 32786289; PMCID: PMC7442712.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    68. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 07 14; 4(13):2899-2911. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729; PMCID: PMC7362346.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    69. CRISPR-based functional genomics for neurological disease. Nat Rev Neurol. 2020 09; 16(9):465-480. Kampmann M. PMID: 32641861; PMCID: PMC7484261.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    70. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2020 07 02; 79(1):191-198.e3. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. PMID: 32619469; PMCID: PMC7332992.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsPHPublic Health
    71. LRP1 is a master regulator of tau uptake and spread. Nature. 2020 04; 580(7803):381-385. Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. PMID: 32296178; PMCID: PMC7687380.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    72. A High-throughput CRISPR Interference Screen to Dissect Functional Regulators of GPCR/cAMP Signaling. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Semesta SK, Tian TR, Kampmann KM, von Zastrow vM, Tsvetanova TN. .
      View in: Publisher Site   Mentions:
    73. Deep mutational scanning reveals the structural basis for α-synuclein activity. Nat Chem Biol. 2020 06; 16(6):653-659. Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. PMID: 32152544; PMCID: PMC7339969.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    74. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020 03; 579(7799):427-432. Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M. PMID: 32132707; PMCID: PMC7147832.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansCells
    75. Gene expression and cell identity controlled by anaphase-promoting complex. Nature. 2020 03; 579(7797):136-140. Oh E, Mark KG, Mocciaro A, Watson ER, Prabu JR, Cha DD, Kampmann M, Gamarra N, Zhou CY, Rape M. PMID: 32076268; PMCID: PMC7402266.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    76. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem. 2019 12 13; 294(50):18952-18966. Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. PMID: 31578281; PMCID: PMC6916486.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    77. Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses. Mol Cell Proteomics. 2019 12; 18(12):2401-2417. Uckeley ZM, Moeller R, Kühn LI, Nilsson E, Robens C, Lasswitz L, Lindqvist R, Lenman A, Passos V, Voss Y, Sommerauer C, Kampmann M, Goffinet C, Meissner F, Överby AK, Lozach PY, Gerold G. PMID: 31570497; PMCID: PMC6885706.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    78. CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons. Neuron. 2019 10 23; 104(2):239-255.e12. Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, Ward ME, Kampmann M. PMID: 31422865; PMCID: PMC6813890.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansCells
    79. Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. PMID: 31149896; PMCID: PMC6588346.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    80. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 04 04; 74(1):32-44.e8. Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV. PMID: 30846318; PMCID: PMC7696670.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    81. Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science. 2019 02 15; 363(6428). Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. PMID: 30765536; PMCID: PMC6524780.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    82. Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3052-3061. Poulard C, Kim HN, Fang M, Kruth K, Gagnieux C, Gerke DS, Bhojwani D, Kim YM, Kampmann M, Stallcup MR, Pufall MA. PMID: 30733284; PMCID: PMC6386662.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    83. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926. Ramkumar RP, Leong LJ, Seyler SM, Georgoulis GS, Hyrenius Wittsten HA, Choudhry CP, Roybal RK, Wiita WA, Kampmann KM. .
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    84. A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 2018 08; 16(8):e2004624. Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K. PMID: 30148842; PMCID: PMC6110572.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    85. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424; PMCID: PMC6247911.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    86. Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Biol Open. 2018 Jul 23; 7(7). Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS. PMID: 30037883; PMCID: PMC6078352.
      View in: PubMed   Mentions: 14     Fields:    
    87. Mapping the Genetic Landscape of Human Cells. Cell. 2018 08 09; 174(4):953-967.e22. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA. PMID: 30033366; PMCID: PMC6426455.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    88. Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Sci Rep. 2018 04 23; 8(1):6382. Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS. PMID: 29686391; PMCID: PMC5913225.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    89. CRISPR-based genetic interaction maps inform therapeutic strategies in cancer. Transl Cancer Res. 2018 Feb; 7(Suppl 1):S61-S67. Ramkumar P, Kampmann M. PMID: 30148072; PMCID: PMC6107073.
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    90. Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nat Biotechnol. 2018 02; 36(2):170-178. Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT. PMID: 29334369; PMCID: PMC6072461.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    91. CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine. ACS Chem Biol. 2018 02 16; 13(2):406-416. Kampmann M. PMID: 29035510; PMCID: PMC5886776.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimals
    92. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2017 Oct 05; 68(1):210-223.e6. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. PMID: 28985505; PMCID: PMC5640507.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    93. Abstract A30: Identifying microenvironment-dependent vulnerabilities in multiple myeloma using CRISPRi. Finding Synthetic Lethal Interactions through Functional Genomics. 2017 Oct 1; a30-a30. Ramkumar RP, Tawney TJ, Acosta-Alvear AD, Kampmann KM. .
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    94. CRISPulator: a discrete simulation tool for pooled genetic screens. BMC Bioinformatics. 2017 Jul 21; 18(1):347. Nagy T, Kampmann M. PMID: 28732459; PMCID: PMC5521134.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    95. Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells. Chem Commun (Camb). 2017 Jun 29; 53(53):7162-7167. Kampmann M. PMID: 28487920; PMCID: PMC5507204.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    96. A CRISPR Approach to Neurodegenerative Diseases. Trends Mol Med. 2017 06; 23(6):483-485. Kampmann M. PMID: 28478951; PMCID: PMC5604856.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    97. Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia. Blood. 2017 06 01; 129(22):3000-3008. Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA. PMID: 28424165; PMCID: PMC5454339.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    98. Inhibiting pathways involved in B-cell development enhances sensitivity of B-cell acute lymphoblastic leukemia to glucocorticoids. The FASEB Journal. 2017 Apr 1; 31(S1). Pufall PM, Kruth KK, Fang FM, Shelton SD, Abu-Halawa AO, Tasian TS, Kampmann KM. .
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    99. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. PMID: 27978436; PMCID: PMC5354304.
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    100. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 Sep 23; 5. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS. PMID: 27661255; PMCID: PMC5094855.
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    101. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nat Chem Biol. 2016 May; 12(5):361-6. Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC. PMID: 27018887; PMCID: PMC4836973.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    102. Abstract A2-12: Opposing roles of the 19S regulatory and 20S core proteasomal subunits in controlling sensitivity to proteasome inhibitors. Genomics and Target Discovery. 2015 Nov 15; a2-12-a2-12. Cho CM, Acosta-Alvear AD, Kampmann KM, Wild WT, Choudhary CC, Weissman WJ, Walter WP. .
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    103. Abstract A2-56: Cancer-specific synthetic lethality and network rewiring elucidated by genetic interaction maps and CRISPR-based gain- and loss-of-function screens. Network-Based Cancer Biology. 2015 Nov 15; a2-56-a2-56. Kampmann KM, Acosta-Alvear AD, Gilbert GL, Horlbeck HM, Cho CM, Adamson AB, Villalta VJ, Chen CY, Walter WP, Weissman WJ. .
      View in: Publisher Site   Mentions:
    104. Abstract PR05: Using genome-scale CRISPR-mediated loss-of-function and gain-of-function screens to analyze gene-drug interactions in cancer. Genomics and Target Discovery. 2015 Nov 15; pr05-pr05. Gilbert GL, Tanenbaum TM, Horlbeck HM, Adamson AB, Villalta VJ, Vale VR, Kampmann KM, Weissman WJ. .
      View in: Publisher Site   Mentions:
    105. Abstract A2-57: Identification of genetic vulnerabilities within the proteostasis network of multiple myeloma. Network-Based Cancer Biology. 2015 Nov 15; a2-57-a2-57. Acosta-Alvear AD, Kampmann KM, Cho CM, Aftab AB, Li LX, Gestwicki GJ, Shuman SM, Weissman WJ, Walter WP. .
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    106. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 2015 Nov 09; 28(5):653-665. Anderson DJ, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, Wang J, Yao B, Valle E, Kiss von Soly S, Madriaga A, Soriano F, Menon MK, Wu ZY, Kampmann M, Chen Y, Weissman JS, Aftab BT, Yakes FM, Shawver L, Zhou HJ, Wustrow D, Rolfe M. PMID: 26555175; PMCID: PMC4941640.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    107. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015 Sep 01; 4:e08153. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. PMID: 26327694; PMCID: PMC4602331.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    108. Abstract A43: Opposing roles of the 19S regulatory- and 20S core-proteasomal subunits in controlling sensitivity of multiple myeloma cells to proteasome inhibition. Myeloma. 2015 Sep 1; a43-a43. Acosta-Alvear AD, Kampmann KM, Cho CM, Wild WT, Choudhary CC, Shuman SM, Weissman WJ, Walter WP. .
      View in: Publisher Site   Mentions:
    109. Next-generation libraries for robust RNA interference-based genome-wide screens. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3384-91. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS. PMID: 26080438; PMCID: PMC4491794.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    110. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. PMID: 25875391; PMCID: PMC4426669.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    111. Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2015 Apr; 10(4):643. Kampmann M, Bassik MC, Weissman JS. PMID: 25811902.
      View in: PubMed   Mentions:    Fields:    
    112. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. PMID: 25564440; PMCID: PMC4456214.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    113. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. PMID: 25307932; PMCID: PMC4253859.
      View in: PubMed   Mentions: 1311     Fields:    Translation:HumansCells
    114. Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Nucleic Acids Res. 2014 Oct 29; 42(19):12169-76. Gu S, Zhang Y, Jin L, Huang Y, Zhang F, Bassik MC, Kampmann M, Kay MA. PMID: 25270879; PMCID: PMC4231738.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    115. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. PMID: 25262416; PMCID: PMC4201873.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    116. Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2014 Aug; 9(8):1825-47. Kampmann M, Bassik MC, Weissman JS. PMID: 24992097; PMCID: PMC4144868.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    117. Unraveling the Mechanism of Cell Death Induced by Chemical and Protein Fibrils. Biophysical Journal. 2014 Jan 1; 106(2):40a. Julien JO, Kampmann KM, Bassik BM, Venditto VV, Zorn ZJ, Rheingold RA, Weissman WJ, Wells WJ. .
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    118. Next-Generation NAMPT Inhibitors For ALL Identified By Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens. Blood. 2013 Nov 15; 122(21):171-171. Wei WM, Matheny MC, Bassik BM, Donnelly DA, Kampmann KM, Iwasaki IM, Piloto PO, Solow-Cordero SD, Bouley BD, Rau RR, Brown BP, McManus MM, Weissman WJ, Cleary CM. .
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    119. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. PMID: 24183972; PMCID: PMC3881547.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    120. Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells. Interpreting the Cancer Genome. 2013 Oct 1; pr07-pr07. Kampmann KM, Acosta-Alvear AD, Cho CM, Chen CY, Li LX, Gilbert GL, Aftab AB, Gestwicki GJ, Walter WP, Weissman WJ. .
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    121. Abstract C01: Systematic blueprinting of genetic vulnerabilities using ultra-complex shRNA libraries identifies genes synergizing with proteasome inhibition or blockade of IRE1 in multiple myeloma cells. Signaling and Drug Resistance. 2013 Oct 1; c01-c01. Acosta-Alvear AD, Kampmann KM, Bassik BM, Lee LC, Cho CM, Aftab AB, Li LX, Gestwicki GJ, Shuman SM, Weissman WJ, Walter WP. .
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    122. Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2317-26. Kampmann M, Bassik MC, Weissman JS. PMID: 23739767; PMCID: PMC3690882.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    123. Abstract PR06: Systematic genetic interaction maps reveal synthetic-lethal vulnerabilities in leukemia and multiple myeloma. Systemic Functional Genomics. 2013 May 1; pr06-pr06. Kampmann KM, Acosta-Alvear AD, Bassik BM, Chen CY, Walter WP, Weissman WJ. .
      View in: Publisher Site   Mentions:
    124. Abstract A08: Systematic identification of genetic vulnerabilities synergizing with proteasome and IRE1 inhibition in multiple myeloma cells using ultra-complex shRNA libraries. Genome Scale Synthetic Lethal Screens in Model Organisms. 2013 May 1; a08-a08. Acosta-Alvear AD, Kampmann KM, Bassik BM, Lee LC, Shuman SM, Weissman WJ, Walter WP. .
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    125. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013 Feb 14; 152(4):909-22. Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS. PMID: 23394947; PMCID: PMC3652613.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansCells
    126. Conserved spatial organization of FG domains in the nuclear pore complex. Biophys J. 2013 Jan 08; 104(1):37-50. Atkinson CE, Mattheyses AL, Kampmann M, Simon SM. PMID: 23332057; PMCID: PMC3540264.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    127. Effect of FG Motifs on Ordering Proteins within the Nuclear Pore Complex. Biophysical Journal. 2012 Jan 1; 102(3):525a. Atkinson AC, Mattheyses MA, Kampmann KM, Simon SS. .
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    128. Knocking out the door to tunicamycin entry. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11731-2. Bassik MC, Kampmann M. PMID: 21734150; PMCID: PMC3141928.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    129. Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy. Nat Struct Mol Biol. 2011 Jun; 18(6):643-9. Kampmann M, Atkinson CE, Mattheyses AL, Simon SM. PMID: 21499242; PMCID: PMC3109191.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    130. Protein Domain Organization in the Nuclear Pore Complex Studied by Fluorescence Anisotropy. Biophysical Journal. 2011 Feb 1; 100(3):139a-140a. Mattheyses MA, Kampmann KM, Atkinson AC, Simon SS. .
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    131. The Structure of the Nuclear Pore Complex Studied by Fluorescence Anisotropy. Biophysical Journal. 2011 Feb 1; 100(3):140a. Atkinson AC, Kampmann KM, Mattheyses MA, Simon SS. .
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    132. Fluorescence anisotropy reveals order and disorder of protein domains in the nuclear pore complex. Biophys J. 2010 Sep 22; 99(6):1706-17. Mattheyses AL, Kampmann M, Atkinson CE, Simon SM. PMID: 20858414; PMCID: PMC2941012.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    133. Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain. J Mol Biol. 2010 Sep 10; 402(1):154-64. Leung AK, Kambach C, Kondo Y, Kampmann M, Jinek M, Nagai K. PMID: 20643141.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    134. Biochemistry. Nascent proteins caught in the act. Science. 2009 Dec 04; 326(5958):1352-3. Kampmann M, Blobel G. PMID: 19965743.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    135. Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17693-8. Nagy V, Hsia KC, Debler EW, Kampmann M, Davenport AM, Blobel G, Hoelz A. PMID: 19805193; PMCID: PMC2764879.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    136. Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex. Nat Struct Mol Biol. 2009 Jul; 16(7):782-8. Kampmann M, Blobel G. PMID: 19503077; PMCID: PMC2706296.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    137. Facilitated diffusion in chromatin lattices: mechanistic diversity and regulatory potential. Mol Microbiol. 2005 Aug; 57(4):889-99. Kampmann M. PMID: 16091032.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    138. Reverse gyrase has heat-protective DNA chaperone activity independent of supercoiling. Nucleic Acids Res. 2004; 32(12):3537-45. Kampmann M, Stock D. PMID: 15247343; PMCID: PMC484171.
      View in: PubMed   Mentions: 35     Fields:    
    139. Obstacle bypass in protein motion along DNA by two-dimensional rather than one-dimensional sliding. J Biol Chem. 2004 Sep 10; 279(37):38715-20. Kampmann M. PMID: 15234977.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
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