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Martin Kampmann, PhD

Title(s)Associate Professor, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-514-5545
ORCID ORCID Icon0000-0002-3819-7019 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Marburg University, Marburg, GermanyVordiplom06/2000Human Biology
    Cambridge University, Cambridge, UKBA / MA06/2003Biochemistry
    The Rockefeller University, New York, NYPhD06/2009Cell Biology, Biophysics
    UCSF, San FranciscoPostdoctoral Fellow07/2015Systems Biology
    Collapse Awards and Honors
    Chan Zuckerberg Initiative2018Ben Barres Early Career Acceleration Award
    Chan Zuckerberg Biohub2017Investigator Award
    Stand Up 2 Cancer2016  - 2019Innovative Research Grant
    NIH2015  - 2020New Innovator Award
    Paul G. Allen Family Foundation2015  - 2018Allen Distinguished Investigator Award
    NIH/NCI2014  - 2018Pathway to Independence Award (K99/R00)
    Program for Breakthrough Biomedical Research, UCSF2012Postdoctoral Fellowship
    Jane Coffin Childs Memorial Fund2010  - 2013Postdoctoral Fellowship
    The Rockefeller University2006David Rockefeller Fellowship
    Howard Hughes Medical Institute2003  - 2008Predoctoral Fellowship
    Magdalene College, Cambridge University2003Saunders Prize for Natural Sciences
    Magdalene College, Cambridge University2002Keilin Prize for Natural Sciences
    German National Merit Foundation (Studienstiftung)1999  - 2003Undergraduate Scholarship

    Collapse Overview 
    Collapse Overview
    The Kampmann lab develops and uses innovative technologies to understand cellular and molecular mechanisms of human diseases, and to discover new therapeutic strategies.

    A major focus of our research are diseases associated with protein misfolding, such as neurodegenerative diseases. We ask how cells maintain their proteins in a functional and balanced state. In human cells, this is accomplished by a network of over 1,000 different factors called the proteostasis network. Our goal is to understand how this network functions, and how it is challenged and rewired in disease states.

    Our functional genomics technology, which integrates CRISPR/Cas9-based control of gene function and large-scale genetic interaction maps, enables us to elucidate dynamic networks and to pinpoint nodes that are potential therapeutic targets. CRISPRi and CRISPRa genetic screens in cells derived from human induced pluripotent stem cells (hiPSCs) can reveal mechanisms of disease-associated genes and of selective vulnerability of specific cell types. We use biochemistry, biophysics and cell biology to "zoom in" on individual nodes of the network and to reveal their mechanism of action.

    Collapse Research 
    Collapse Research Activities and Funding
    Systematic elucidation of endosomal trafficking as a therapeutic opportunity in AD using CRISPR-based functional genomics
    NIH R01AG062359Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    Uncovering mechanisms of selective vulnerability by CRISPR-based genetic screens
    NIH R56AG057528Sep 30, 2018 - Jun 30, 2020
    Role: Principal Investigator
    The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes
    NIH U01MH115747Sep 5, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Linking tau proteostasis with neuronal activity in FTD
    NIH U54NS100717Sep 30, 2016 - Aug 31, 2021
    Role: Co-Investigator
    Rewiring of the human protein homeostasis network in normal and disease contexts
    NIH DP2GM119139Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator
    Stress response networks in cancer: systematic mapping and therapeutic potential
    NIH R00CA181494Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Stress response networks in cancer: systematic mapping and therapeutic potential
    NIH K99CA181494Aug 1, 2014 - Jul 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 2021 Apr 07. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. PMID: 33838111.
      View in: PubMed   Mentions:    Fields:    
    2. Patterns of neuronal Rhes as a novel hallmark of tauopathies. Acta Neuropathol. 2021 Mar 07. Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. PMID: 33677647.
      View in: PubMed   Mentions:    Fields:    
    3. Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability. Cell Stress Chaperones. 2021 Feb 05. Abrams J, Arhar T, Mok SA, Taylor IR, Kampmann M, Gestwicki JE. PMID: 33547632.
      View in: PubMed   Mentions:    Fields:    
    4. Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. J Cell Biol. 2021 Feb 01; 220(2). Kanfer G, Sarraf SA, Maman Y, Baldwin H, Dominguez-Martin E, Johnson KR, Ward ME, Kampmann M, Lippincott-Schwartz J, Youle RJ. PMID: 33464298.
      View in: PubMed   Mentions: 1     Fields:    
    5. BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2. bioRxiv. 2021 Jan 19. Tian R, Samelson AJ, Rezelj VV, Chen M, Ramadoss GN, Guo X, Kain AM, Tran QD, Lim SA, Lui I, Nunez J, Rockwood SJ, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin B, Vignuzzi M, Kampmann M. PMID: 33501440.
      View in: PubMed   Mentions:
    6. Molecular characterization of selectively vulnerable neurons in Alzheimer's disease. Nat Neurosci. 2021 Jan 11. Leng K, Li E, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M. PMID: 33432193.
      View in: PubMed   Mentions: 1     Fields:    
    7. A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. PLoS Genet. 2020 10; 16(10):e1009103. Semesta KM, Tian R, Kampmann M, von Zastrow M, Tsvetanova NG. PMID: 33052901.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Defining the ATPome reveals cross-optimization of metabolic pathways. Nat Commun. 2020 08 28; 11(1):4319. Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. PMID: 32859923.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Robust Sequence Determinants of a-Synuclein Toxicity in Yeast Implicate Membrane Binding. ACS Chem Biol. 2020 08 21; 15(8):2137-2153. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M. PMID: 32786289.
      View in: PubMed   Mentions:    Fields:    
    10. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 Jul 14; 4(13):2899-2911. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729.
      View in: PubMed   Mentions: 1     Fields:    
    11. CRISPR-based functional genomics for neurological disease. Nat Rev Neurol. 2020 Sep; 16(9):465-480. Kampmann M. PMID: 32641861.
      View in: PubMed   Mentions: 1     Fields:    
    12. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2020 07 02; 79(1):191-198.e3. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. PMID: 32619469.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    13. LRP1 is a master regulator of tau uptake and spread. Nature. 2020 04; 580(7803):381-385. Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. PMID: 32296178.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    14. A High-throughput CRISPR Interference Screen to Dissect Functional Regulators of GPCR/cAMP Signaling. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Khairunnisa Mentari Semesta, Ruilin Tian, Martin Kampmann, Mark von Zastrow, Nikoleta G. Tsvetanova. .
      View in: Publisher Site   Mentions:
    15. Deep mutational scanning reveals the structural basis for a-synuclein activity. Nat Chem Biol. 2020 06; 16(6):653-659. Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. PMID: 32152544.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020 03; 579(7799):427-432. Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M. PMID: 32132707.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    17. Gene expression and cell identity controlled by anaphase-promoting complex. Nature. 2020 03; 579(7797):136-140. Oh E, Mark KG, Mocciaro A, Watson ER, Prabu JR, Cha DD, Kampmann M, Gamarra N, Zhou CY, Rape M. PMID: 32076268.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem. 2019 12 13; 294(50):18952-18966. Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. PMID: 31578281.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses. Mol Cell Proteomics. 2019 12; 18(12):2401-2417. Uckeley ZM, Moeller R, Kühn LI, Nilsson E, Robens C, Lasswitz L, Lindqvist R, Lenman A, Passos V, Voss Y, Sommerauer C, Kampmann M, Goffinet C, Meissner F, Överby AK, Lozach PY, Gerold G. PMID: 31570497.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons. Neuron. 2019 10 23; 104(2):239-255.e12. Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, Ward ME, Kampmann M. PMID: 31422865.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    21. Ceapins block the unfolded protein response sensor ATF6a by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. PMID: 31149896.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 04 04; 74(1):32-44.e8. Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV. PMID: 30846318.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    23. Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science. 2019 02 15; 363(6428). Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. PMID: 30765536.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    24. Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3052-3061. Poulard C, Kim HN, Fang M, Kruth K, Gagnieux C, Gerke DS, Bhojwani D, Kim YM, Kampmann M, Stallcup MR, Pufall MA. PMID: 30733284.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926. Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann. .
      View in: Publisher Site   Mentions:
    26. A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 2018 08; 16(8):e2004624. Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K. PMID: 30148842.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    28. Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Biol Open. 2018 Jul 23; 7(7). Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS. PMID: 30037883.
      View in: PubMed   Mentions:
    29. Mapping the Genetic Landscape of Human Cells. Cell. 2018 08 09; 174(4):953-967.e22. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA. PMID: 30033366.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    30. Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Sci Rep. 2018 04 23; 8(1):6382. Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS. PMID: 29686391.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    31. CRISPR-based genetic interaction maps inform therapeutic strategies in cancer. Transl Cancer Res. 2018 Feb; 7(Suppl 1):S61-S67. Ramkumar P, Kampmann M. PMID: 30148072.
      View in: PubMed   Mentions:
    32. Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nat Biotechnol. 2018 02; 36(2):170-178. Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT. PMID: 29334369.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    33. CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine. ACS Chem Biol. 2018 02 16; 13(2):406-416. Kampmann M. PMID: 29035510.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    34. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2017 Oct 05; 68(1):210-223.e6. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. PMID: 28985505.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    35. CRISPulator: a discrete simulation tool for pooled genetic screens. BMC Bioinformatics. 2017 Jul 21; 18(1):347. Nagy T, Kampmann M. PMID: 28732459.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    36. Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells. Chem Commun (Camb). 2017 Jun 29; 53(53):7162-7167. Kampmann M. PMID: 28487920.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. A CRISPR Approach to Neurodegenerative Diseases. Trends Mol Med. 2017 06; 23(6):483-485. Kampmann M. PMID: 28478951.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    38. Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia. Blood. 2017 06 01; 129(22):3000-3008. Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA. PMID: 28424165.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    39. The mTOR Complex Controls HIV Latency. . 2016 Dec 14; 20(6):785-797. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. PMID: 27978436.
      View in: PubMed   Mentions:
    40. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 09 23; 5. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS. PMID: 27661255.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    41. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nat Chem Biol. 2016 May; 12(5):361-6. Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC. PMID: 27018887.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    42. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 2015 Nov 09; 28(5):653-665. Anderson DJ, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, Wang J, Yao B, Valle E, Kiss von Soly S, Madriaga A, Soriano F, Menon MK, Wu ZY, Kampmann M, Chen Y, Weissman JS, Aftab BT, Yakes FM, Shawver L, Zhou HJ, Wustrow D, Rolfe M. PMID: 26555175.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    43. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015 Sep 01; 4:e08153. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. PMID: 26327694.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    44. Next-generation libraries for robust RNA interference-based genome-wide screens. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3384-91. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS. PMID: 26080438.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    45. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. PMID: 25875391.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    46. Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2015 Apr; 10(4):643. Kampmann M, Bassik MC, Weissman JS. PMID: 25811902.
      View in: PubMed   Mentions:    Fields:    
    47. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. . 2015 Mar; 14(3):642-8. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. PMID: 25564440.
      View in: PubMed   Mentions:
    48. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. PMID: 25307932.
      View in: PubMed   Mentions: 557     Fields:    Translation:HumansCells
    49. Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Nucleic Acids Res. 2014 Oct 29; 42(19):12169-76. Gu S, Zhang Y, Jin L, Huang Y, Zhang F, Bassik MC, Kampmann M, Kay MA. PMID: 25270879.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    50. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. PMID: 25262416.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    51. Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2014 Aug; 9(8):1825-47. Kampmann M, Bassik MC, Weissman JS. PMID: 24992097.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    52. Unraveling the Mechanism of Cell Death Induced by Chemical and Protein Fibrils. Biophysical Journal. 2014 Jan 1; 106(2):40a. Olivier Julien, Martin Kampmann, Michael C. Bassik, Vincent J. Venditto, Julie A. Zorn, Arnold L. Rheingold, Jonathan S. Weissman, James A. Wells. .
      View in: Publisher Site   Mentions:
    53. Next-Generation NAMPT Inhibitors For ALL Identified By Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens. Blood. 2013 Nov 15; 122(21):171-171. Michael C. Wei, Christina J. Matheny, Michael C. Bassik, Alicia J. Donnelly, Martin Kampmann, Masayuki Iwasaki, Obdulio Piloto, David E. Solow-Cordero, Donna Bouley, Rachel E. Rau, Patrick Brown, Michael T. McManus, Jonathan S. Weissman, Michael L. Cleary. .
      View in: Publisher Site   Mentions:
    54. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. PMID: 24183972.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    55. Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2317-26. Kampmann M, Bassik MC, Weissman JS. PMID: 23739767.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    56. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013 Feb 14; 152(4):909-22. Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS. PMID: 23394947.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    57. Conserved spatial organization of FG domains in the nuclear pore complex. Biophys J. 2013 Jan 08; 104(1):37-50. Atkinson CE, Mattheyses AL, Kampmann M, Simon SM. PMID: 23332057.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    58. Effect of FG Motifs on Ordering Proteins within the Nuclear Pore Complex. Biophysical Journal. 2012 Jan 1; 102(3):525a. Claire E. Atkinson, Alexa L. Mattheyses, Martin Kampmann, Sanford M. Simon. .
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    59. Knocking out the door to tunicamycin entry. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11731-2. Bassik MC, Kampmann M. PMID: 21734150.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    60. Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy. Nat Struct Mol Biol. 2011 Jun; 18(6):643-9. Kampmann M, Atkinson CE, Mattheyses AL, Simon SM. PMID: 21499242.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    61. Protein Domain Organization in the Nuclear Pore Complex Studied by Fluorescence Anisotropy. Biophysical Journal. 2011 Feb 1; 100(3):139a-140a. Alexa L. Mattheyses, Martin Kampmann, Claire E. Atkinson, Sanford M. Simon. .
      View in: Publisher Site   Mentions:
    62. The Structure of the Nuclear Pore Complex Studied by Fluorescence Anisotropy. Biophysical Journal. 2011 Feb 1; 100(3):140a. Claire E. Atkinson, Martin Kampmann, Alexa L. Mattheyses, Sanford M. Simon. .
      View in: Publisher Site   Mentions:
    63. Fluorescence anisotropy reveals order and disorder of protein domains in the nuclear pore complex. Biophys J. 2010 Sep 22; 99(6):1706-17. Mattheyses AL, Kampmann M, Atkinson CE, Simon SM. PMID: 20858414.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    64. Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain. J Mol Biol. 2010 Sep 10; 402(1):154-64. Leung AK, Kambach C, Kondo Y, Kampmann M, Jinek M, Nagai K. PMID: 20643141.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    65. Biochemistry. Nascent proteins caught in the act. Science. 2009 Dec 04; 326(5958):1352-3. Kampmann M, Blobel G. PMID: 19965743.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    66. Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17693-8. Nagy V, Hsia KC, Debler EW, Kampmann M, Davenport AM, Blobel G, Hoelz A. PMID: 19805193.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    67. Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex. Nat Struct Mol Biol. 2009 Jul; 16(7):782-8. Kampmann M, Blobel G. PMID: 19503077.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    68. Facilitated diffusion in chromatin lattices: mechanistic diversity and regulatory potential. Mol Microbiol. 2005 Aug; 57(4):889-99. Kampmann M. PMID: 16091032.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    69. Reverse gyrase has heat-protective DNA chaperone activity independent of supercoiling. Nucleic Acids Res. 2004; 32(12):3537-45. Kampmann M, Stock D. PMID: 15247343.
      View in: PubMed   Mentions: 22     Fields:    
    70. Obstacle bypass in protein motion along DNA by two-dimensional rather than one-dimensional sliding. J Biol Chem. 2004 Sep 10; 279(37):38715-20. Kampmann M. PMID: 15234977.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
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