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Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent. Org Lett. 2021 05 21; 23(10):3823-3827.
Nguyen TH, O'Brien CJ, Tran MLN, Olson SH, Settineri NS, Prusiner SB, Paras NA, Conrad J. PMID: 33929208.
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Silver Benzoate Facilitates the Copper-Catalyzed C-N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles. ACS Omega. 2021 Apr 13; 6(14):9804-9812.
Lozano C, Ramirez C, Sin N, Viart HM, Prusiner SB, Paras NA, Conrad J. PMID: 33869960.
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Selectivity in the Addition of Electron‐Deficient Radicals to the C2 Position of Indoles. European Journal of Organic Chemistry. 2020; 2020(36):5828-5832.
Yi Li, Roy J Vaz, Steven H Olson, Mark Munson, Nick A Paras, Jay Conrad. View Publication.
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Expanding spectrum of prion diseases. Emerg Top Life Sci. 2020 09 08; 4(2):155-167.
Ayers JI, Paras NA, Prusiner SB. PMID: 32803268.
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Selectivity in the Addition of Electron Deficient Radicals to the C2 Position of Indoles. European J Org Chem. 2020 Sep 30; 2020(36):5828-5832.
Li Y, Vaz RJ, Olson SH, Munson M, Paras NA, Conrad J. PMID: 33692651.
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Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity. ACS Med Chem Lett. 2020 Feb 13; 11(2):127-132.
Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, Inoue M, Olson SH, Prusiner SB, Conrad J, Paras NA. PMID: 32071678.
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AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 12; 8(12):1582-1597.
Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE. PMID: 30254093.
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82 Fields:
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Photoredox Cyanomethylation of Indoles: Catalyst Modification and Mechanism. J Org Chem. 2018 08 17; 83(16):8926-8935.
O'Brien CJ, Droege DG, Jiu AY, Gandhi SS, Paras NA, Olson SH, Conrad J. PMID: 29940725.
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4 Fields:
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Cells
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Deutetrabenazine for Treatment of Chorea in Huntington Disease. JAMA. 2016 Jul 05; 316(1):33-5.
Geschwind MD, Paras N. PMID: 27380339.
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2 Fields:
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Humans
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Convenient route to secondary sulfinates: application to the stereospecific synthesis of a-C-chiral sulfonamides. Org Lett. 2014 Dec 05; 16(23):6248-51.
Johnson MG, Gribble MW, Houze JB, Paras NA. PMID: 25415837.
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1 Fields:
Translation:
Cells
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Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. J Med Chem. 2009 Oct 22; 52(20):6189-92.
Smith AL, DeMorin FF, Paras NA, Huang Q, Petkus JK, Doherty EM, Nixey T, Kim JL, Whittington DA, Epstein LF, Lee MR, Rose MJ, Babij C, Fernando M, Hess K, Le Q, Beltran P, Carnahan J. PMID: 19764794.
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12 Fields:
Translation:
HumansAnimalsCells
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Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing BOC-protected tetrahydroisoquinoline carboxylic acids. J Comb Chem. 2004 Jul-Aug; 6(4):487-96.
Bunin BA, Dener JM, Kelly DE, Paras NA, Tario JD, Tushup SP. PMID: 15244409.
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3 Fields:
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The enantioselective organocatalytic 1,4-addition of electron-rich benzenes to alpha,beta-unsaturated aldehydes. J Am Chem Soc. 2002 Jul 10; 124(27):7894-5.
Paras NA, MacMillan DW. PMID: 12095321.
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14 Fields:
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New strategies in organic catalysis: the first enantioselective organocatalytic Friedel-Crafts alkylation. J Am Chem Soc. 2001 May 09; 123(18):4370-1.
Paras NA, MacMillan DW. PMID: 11457218.
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21 Fields:
Translation:
Cells
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C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Carbonyl−Ene Reactions with Glyoxylate and Pyruvate Esters. Journal of the American Chemical Society. 2000; 122(33):7936-7943.
David A Evans, Steven W Tregay, Christopher S Burgey, Nick A Paras, Tomas Vojkovsky. View Publication.
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C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Enantioselective Catalysis of the Glyoxylate−Ene Reaction. Journal of the American Chemical Society. 1998; 120(23):5824-5825.
David A Evans, Christopher S Burgey, Nick A Paras, Tomas Vojkovsky, Steven W Tregay. View Publication.