Peter Sargent, PhD

Title(s)Professor Emeritus, Cell and Tissue Biology
SchoolSchool of Dentistry
Address35 Medical Center Way
San Francisco CA 94143
Phone415-476-6156
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    Collapse Biography 
    Collapse Education and Training
    Amherst CollegeAB1969
    Harvard UniversityPhD1975Neurobiology
    UC San Franciscopostdoctoral1978Physiology/School of Medicine
    Stanford Universitypostdoctoral1979Neurobiology/School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Nicotinic Synaptic Mechanisms in Chick Ciliary Ganglion
    NIH R01MH068690Apr 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    PRE &POSTSYNAPTIC NICOTINIC ACHRS--STRUCTURE &FUNCTION
    NIH R01MH054251Sep 30, 1996 - Apr 30, 2001
    Role: Principal Investigator
    NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
    NIH R01NS024207Mar 1, 1986 - Dec 31, 2001
    Role: Principal Investigator
    SYNAPSE FORMATION AND GROWTH IN AN AUTONOMIC GANGLION
    NIH R01NS024157Mar 1, 1986 - Feb 28, 1989
    Role: Principal Investigator
    NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
    NIH R01NS022491Sep 1, 1985 - Feb 28, 1986
    Role: Principal Investigator
    POSTSYNAPTIC PROTEINS AT THE NEUROMUSCULAR JUNCTION
    NIH R01NS013521Jul 1, 1977 - Jun 30, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine. J Neurosci. 2011 Oct 19; 31(42):14920-30. Stanchev D, Sargent PB. PMID: 22016525; PMCID: PMC3342687.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    2. Nicotinic receptors concentrated in the subsynaptic membrane do not contribute significantly to synaptic currents at an embryonic synapse in the chicken ciliary ganglion. J Neurosci. 2009 Mar 25; 29(12):3749-59. Sargent PB. PMID: 19321771; PMCID: PMC2696354.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    3. Evolution and revolution: the curriculum reform process at UCSF. J Dent Educ. 2008 Dec; 72(12):1516-30. Ryder MI, Sargent P, Perry D. PMID: 19056631.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse. J Neurosci. 2005 Sep 07; 25(36):8173-87. Sargent PB, Saviane C, Nielsen TA, DiGregorio DA, Silver RA. PMID: 16148225; PMCID: PMC6725539.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    5. Rapid activation of presynaptic nicotinic acetylcholine receptors by nerve-released transmitter. Eur J Neurosci. 2003 Dec; 18(11):2946-56. Rogers M, Sargent PB. PMID: 14656290.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    6. Synaptic vesicle recycling at two classes of release sites in giant nerve terminals of the embryonic chicken ciliary ganglion. J Comp Neurol. 2002 Jun 24; 448(2):128-37. Nguyen D, Sargent PB. PMID: 12012425.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. Properties of nicotinic receptors underlying Renshaw cell excitation by alpha-motor neurons in neonatal rat spinal cord. J Neurophysiol. 2002 Jun; 87(6):3117-25. Dourado M, Sargent PB. PMID: 12037212.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    8. Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6157-62. Sheets MD, Amersdorfer P, Finnern R, Sargent P, Lindquist E, Schier R, Hemingsen G, Wong C, Gerhart JC, Marks JD, Lindqvist E. PMID: 9600934; PMCID: PMC27609.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    9. Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors. J Neurosci. 1997 Oct 01; 17(19):7210-9. Ullian EM, McIntosh JM, Sargent PB. PMID: 9295367; PMCID: PMC6573447.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    10. Effects of denervation on acetylcholine receptor clusters on frog cardiac ganglion neurons as revealed by quantitative laser scanning confocal microscopy. J Neurosci. 1996 Mar 01; 16(5):1720-9. Horch HL, Sargent PB. PMID: 8774440; PMCID: PMC6578683.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Synaptic and extrasynaptic distribution of two distinct populations of nicotinic acetylcholine receptor clusters in the frog cardiac ganglion. J Neurocytol. 1996 Jan; 25(1):67-77. Wilson Horch HL, Sargent PB. PMID: 8852939.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion. J Neurosci. 1995 Dec; 15(12):7778-95. Horch HL, Sargent PB. PMID: 8613719; PMCID: PMC6577917.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    13. Pronounced cellular diversity and extrasynaptic location of nicotinic acetylcholine receptor subunit immunoreactivities in the chicken pretectum. J Neurosci. 1995 Nov; 15(11):7012-23. Ullian EM, Sargent PB. PMID: 7472457; PMCID: PMC6578067.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    14. The characterization of alpha-bungarotoxin receptors on the surface of parasympathetic neurons in the frog heart. Brain Res. 1995 May 22; 680(1-2):99-107. Sargent PB, Garrett EN. PMID: 7663990.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. Double-label immunofluorescence with the laser scanning confocal microscope using cyanine dyes. Neuroimage. 1994 Nov; 1(4):288-95. Sargent PB. PMID: 9343578.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci. 1993; 16:403-43. Sargent PB. PMID: 7681637.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    17. The role of acetylcholinesterase in denervation supersensitivity in the frog cardiac ganglion. J Physiol. 1992 Jan; 445:249-60. Streichert LC, Sargent PB. PMID: 1501134; PMCID: PMC1179980.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    18. Denervation does not alter the number of neuronal bungarotoxin binding sites on autonomic neurons in the frog cardiac ganglion. J Neurosci. 1991 Nov; 11(11):3610-23. Sargent PB, Bryan GK, Streichert LC, Garrett EN. PMID: 1941098; PMCID: PMC6575533.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Differential effects of denervation on acetylcholinesterase activity in parasympathetic and sympathetic ganglia of the frog, Rana pipiens. J Neurobiol. 1990 Sep; 21(6):938-49. Streichert LC, Sargent PB. PMID: 2077105.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    20. Acetylcholine receptor-like molecules are found in both synaptic and extrasynaptic clusters on the surface of neurons in the frog cardiac ganglion. J Neurosci. 1989 Mar; 9(3):1062-72. Sargent PB, Pang DZ. PMID: 2784494; PMCID: PMC6569971.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. Bouton ultrastructure and synaptic growth in a frog autonomic ganglion. J Comp Neurol. 1989 Mar 01; 281(1):159-68. Streichert LC, Sargent PB. PMID: 2925900.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    22. Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog. J Neurosci. 1989 Feb; 9(2):565-73. Sargent PB, Pike SH, Nadel DB, Lindstrom JM. PMID: 2645388; PMCID: PMC6569808.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. Denervation alters the size, number, and distribution of clusters of acetylcholine receptor-like molecules on frog cardiac ganglion neurons. Neuron. 1988 Nov; 1(9):877-86. Sargent PB, Pang DZ. PMID: 3272191.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    24. Growth and morphogenesis of an autonomic ganglion. I. Matching neurons with target. J Neurosci. 1987 Aug; 7(8):2493-501. Heathcote RD, Sargent PB. PMID: 3612250; PMCID: PMC6568969.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    25. Growth and morphogenesis of an autonomic ganglion. II. Establishment of neuron position. J Neurosci. 1987 Aug; 7(8):2502-9. Heathcote RD, Sargent PB. PMID: 3612251; PMCID: PMC6568982.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    26. Using monoclonal antibodies to determine the structures of acetylcholine receptors from electric organs, muscles, and neurons. Ann N Y Acad Sci. 1987; 505:208-25. Lindstrom J, Criado M, Ratnam M, Whiting P, Ralston S, Rivier J, Sarin V, Sargent P. PMID: 2446548.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Transmembrane topography of nicotinic acetylcholine receptor: immunochemical tests contradict theoretical predictions based on hydrophobicity profiles. Biochemistry. 1986 May 06; 25(9):2633-43. Ratnam M, Nguyen DL, Rivier J, Sargent PB, Lindstrom J. PMID: 3718969.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    28. Location of antigenic determinants on primary sequences of subunits of nicotinic acetylcholine receptor by peptide mapping. Biochemistry. 1986 May 06; 25(9):2621-32. Ratnam M, Sargent PB, Sarin V, Fox JL, Nguyen DL, Rivier J, Criado M, Lindstrom J. PMID: 2424498.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    29. Loss of supernumerary axons during neuronal morphogenesis. J Neurosci. 1985 Jul; 5(7):1940-6. Heathcote RD, Sargent PB. PMID: 4020426; PMCID: PMC6565111.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    30. The genesis and differentiation of neurons in a frog parasympathetic ganglion. Dev Biol. 1984 Sep; 105(1):102-14. Heathcote RD, Sargent PB. PMID: 6468754.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    31. Structure and transmembrane nature of the acetylcholine receptor in amphibian skeletal muscle as revealed by cross-reacting monoclonal antibodies. J Cell Biol. 1984 Feb; 98(2):609-18. Sargent PB, Hedges BE, Tsavaler L, Clemmons L, Tzartos S, Lindstrom JM. PMID: 6363425; PMCID: PMC2113085.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    32. The number of synaptic boutons terminating on Xenopus cardiac ganglion cells is directly correlated with cell size. J Physiol. 1983 Oct; 343:85-104. Sargent PB. PMID: 6358464; PMCID: PMC1193909.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    33. The influence of normal innervation upon abnormal synaptic connections between frog parasympathetic neurons. Dev Biol. 1981 Jan 15; 81(1):65-73. Sargent PB, Dennis MJ. PMID: 6161853.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    34. Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve. J Cell Biol. 1979 Aug; 82(2):412-25. Burden SJ, Sargent PB, McMahan UJ. PMID: 479308; PMCID: PMC2110475.
      View in: PubMed   Mentions: 79     Fields:    Translation:Animals
    35. Loss of extrasynaptic acetylcholine sensitivity upon reinnervation of parasympathetic ganglion cells. J Physiol. 1979 Apr; 289:263-75. Dennis MJ, Sargent PB. PMID: 313439; PMCID: PMC1281369.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. Multiple innervation of normal and re-innervated parasympathetic neurones in the frog cardiac ganglion. J Physiol. 1978 Aug; 281:63-75. Dennis MJ, Sargent PB. PMID: 212557; PMCID: PMC1282684.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    37. Formation of synapses between parasympathetic neurones deprived of preganglionic innervation. Nature. 1977 Aug 04; 268(5619):456-8. Sargent PB, Dennis MJ. PMID: 197420.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. Extrasynaptic receptors on cell bodies of neurons in central nervous system of the leech. J Neurophysiol. 1977 Mar; 40(2):446-52. Sargent PB, Yau KW, Nicholls JG. PMID: 15048.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    39. Synthesis of acetylcholine by excitatory motoneurons in central nervous system of the leech. J Neurophysiol. 1977 Mar; 40(2):453-60. Sargent PB. PMID: 15049.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    40. Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle (snake venom-denervated muscle-neonatal muscle-rat diaphragm-SDS-polyacrylamide gel electrophoresis). Proc Natl Acad Sci U S A. 1972 Jan; 69(1):147-51. Berg DK, Kelly RB, Sargent PB, Williamson P, Hall ZW. PMID: 4333037; PMCID: PMC427564.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
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