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Peter Sargent, PhD

Title(s)Professor Emeritus, Cell and Tissue Biology
SchoolSchool of Dentistry
Phone415-476-6156
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    Collapse Biography 
    Collapse Education and Training
    Amherst CollegeAB1969
    Harvard UniversityPhD1975Neurobiology
    UC San Franciscopostdoctoral1978Physiology/School of Medicine
    Stanford Universitypostdoctoral1979Neurobiology/School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Nicotinic Synaptic Mechanisms in Chick Ciliary Ganglion
    NIH/NIMH R01MH068690Apr 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    PRE &POSTSYNAPTIC NICOTINIC ACHRS--STRUCTURE &FUNCTION
    NIH/NIMH R01MH054251Sep 30, 1996 - Apr 30, 2001
    Role: Principal Investigator
    NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
    NIH/NINDS R01NS024207Mar 1, 1986 - Dec 31, 2001
    Role: Principal Investigator
    SYNAPSE FORMATION AND GROWTH IN AN AUTONOMIC GANGLION
    NIH/NINDS R01NS024157Mar 1, 1986 - Feb 28, 1989
    Role: Principal Investigator
    NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
    NIH/NINDS R01NS022491Sep 1, 1985 - Feb 28, 1986
    Role: Principal Investigator
    POSTSYNAPTIC PROTEINS AT THE NEUROMUSCULAR JUNCTION
    NIH/NINDS R01NS013521Jul 1, 1977 - Jun 30, 2000
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stanchev D, Sargent PB. a7-Containing and non-a7-containing nicotinic receptors respond differently to spillover of acetylcholine. J Neurosci. 2011 Oct 19; 31(42):14920-30. PMID: 22016525; PMCID: PMC3342687.
      View in: PubMed, PubMed Central
    2. Sargent PB. Nicotinic receptors concentrated in the subsynaptic membrane do not contribute significantly to synaptic currents at an embryonic synapse in the chicken ciliary ganglion. J Neurosci. 2009 Mar 25; 29(12):3749-59. PMID: 19321771; PMCID: PMC2696354.
      View in: PubMed, PubMed Central
    3. Ryder MI, Sargent P, Perry D. Evolution and revolution: the curriculum reform process at UCSF. J Dent Educ. 2008 Dec; 72(12):1516-30. PMID: 19056631.
      View in: PubMed
    4. Sargent PB, Saviane C, Nielsen TA, DiGregorio DA, Silver RA. Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse. J Neurosci. 2005 Sep 07; 25(36):8173-87. PMID: 16148225.
      View in: PubMed
    5. Rogers M, Sargent PB. Rapid activation of presynaptic nicotinic acetylcholine receptors by nerve-released transmitter. Eur J Neurosci. 2003 Dec; 18(11):2946-56. PMID: 14656290.
      View in: PubMed
    6. Nguyen D, Sargent PB. Synaptic vesicle recycling at two classes of release sites in giant nerve terminals of the embryonic chicken ciliary ganglion. J Comp Neurol. 2002 Jun 24; 448(2):128-37. PMID: 12012425.
      View in: PubMed
    7. Dourado M, Sargent PB. Properties of nicotinic receptors underlying Renshaw cell excitation by alpha-motor neurons in neonatal rat spinal cord. J Neurophysiol. 2002 Jun; 87(6):3117-25. PMID: 12037212.
      View in: PubMed
    8. Sheets MD, Amersdorfer P, Finnern R, Sargent P, Lindquist E, Schier R, Hemingsen G, Wong C, Gerhart JC, Marks JD, Lindqvist E. Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6157-62. PMID: 9600934; PMCID: PMC27609.
      View in: PubMed, PubMed Central
    9. Ullian EM, McIntosh JM, Sargent PB. Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors. J Neurosci. 1997 Oct 01; 17(19):7210-9. PMID: 9295367.
      View in: PubMed
    10. Horch HL, Sargent PB. Effects of denervation on acetylcholine receptor clusters on frog cardiac ganglion neurons as revealed by quantitative laser scanning confocal microscopy. J Neurosci. 1996 Mar 01; 16(5):1720-9. PMID: 8774440.
      View in: PubMed
    11. Wilson Horch HL, Sargent PB. Synaptic and extrasynaptic distribution of two distinct populations of nicotinic acetylcholine receptor clusters in the frog cardiac ganglion. J Neurocytol. 1996 Jan; 25(1):67-77. PMID: 8852939.
      View in: PubMed
    12. Horch HL, Sargent PB. Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion. J Neurosci. 1995 Dec; 15(12):7778-95. PMID: 8613719.
      View in: PubMed
    13. Ullian EM, Sargent PB. Pronounced cellular diversity and extrasynaptic location of nicotinic acetylcholine receptor subunit immunoreactivities in the chicken pretectum. J Neurosci. 1995 Nov; 15(11):7012-23. PMID: 7472457.
      View in: PubMed
    14. Sargent PB, Garrett EN. The characterization of alpha-bungarotoxin receptors on the surface of parasympathetic neurons in the frog heart. Brain Res. 1995 May 22; 680(1-2):99-107. PMID: 7663990.
      View in: PubMed
    15. Sargent PB. Double-label immunofluorescence with the laser scanning confocal microscope using cyanine dyes. Neuroimage. 1994 Nov; 1(4):288-95. PMID: 9343578.
      View in: PubMed
    16. Sargent PB. The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci. 1993; 16:403-43. PMID: 7681637.
      View in: PubMed
    17. Streichert LC, Sargent PB. The role of acetylcholinesterase in denervation supersensitivity in the frog cardiac ganglion. J Physiol. 1992 Jan; 445:249-60. PMID: 1501134; PMCID: PMC1179980.
      View in: PubMed, PubMed Central
    18. Sargent PB, Bryan GK, Streichert LC, Garrett EN. Denervation does not alter the number of neuronal bungarotoxin binding sites on autonomic neurons in the frog cardiac ganglion. J Neurosci. 1991 Nov; 11(11):3610-23. PMID: 1941098.
      View in: PubMed
    19. Streichert LC, Sargent PB. Differential effects of denervation on acetylcholinesterase activity in parasympathetic and sympathetic ganglia of the frog, Rana pipiens. J Neurobiol. 1990 Sep; 21(6):938-49. PMID: 2077105.
      View in: PubMed
    20. Sargent PB, Pang DZ. Acetylcholine receptor-like molecules are found in both synaptic and extrasynaptic clusters on the surface of neurons in the frog cardiac ganglion. J Neurosci. 1989 Mar; 9(3):1062-72. PMID: 2784494.
      View in: PubMed
    21. Streichert LC, Sargent PB. Bouton ultrastructure and synaptic growth in a frog autonomic ganglion. J Comp Neurol. 1989 Mar 01; 281(1):159-68. PMID: 2925900.
      View in: PubMed
    22. Sargent PB, Pike SH, Nadel DB, Lindstrom JM. Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog. J Neurosci. 1989 Feb; 9(2):565-73. PMID: 2645388.
      View in: PubMed
    23. Sargent PB, Pang DZ. Denervation alters the size, number, and distribution of clusters of acetylcholine receptor-like molecules on frog cardiac ganglion neurons. Neuron. 1988 Nov; 1(9):877-86. PMID: 3272191.
      View in: PubMed
    24. Heathcote RD, Sargent PB. Growth and morphogenesis of an autonomic ganglion. I. Matching neurons with target. J Neurosci. 1987 Aug; 7(8):2493-501. PMID: 3612250.
      View in: PubMed
    25. Heathcote RD, Sargent PB. Growth and morphogenesis of an autonomic ganglion. II. Establishment of neuron position. J Neurosci. 1987 Aug; 7(8):2502-9. PMID: 3612251.
      View in: PubMed
    26. Lindstrom J, Criado M, Ratnam M, Whiting P, Ralston S, Rivier J, Sarin V, Sargent P. Using monoclonal antibodies to determine the structures of acetylcholine receptors from electric organs, muscles, and neurons. Ann N Y Acad Sci. 1987; 505:208-25. PMID: 2446548.
      View in: PubMed
    27. Ratnam M, Sargent PB, Sarin V, Fox JL, Nguyen DL, Rivier J, Criado M, Lindstrom J. Location of antigenic determinants on primary sequences of subunits of nicotinic acetylcholine receptor by peptide mapping. Biochemistry. 1986 May 06; 25(9):2621-32. PMID: 2424498.
      View in: PubMed
    28. Ratnam M, Nguyen DL, Rivier J, Sargent PB, Lindstrom J. Transmembrane topography of nicotinic acetylcholine receptor: immunochemical tests contradict theoretical predictions based on hydrophobicity profiles. Biochemistry. 1986 May 06; 25(9):2633-43. PMID: 3718969.
      View in: PubMed
    29. Heathcote RD, Sargent PB. Loss of supernumerary axons during neuronal morphogenesis. J Neurosci. 1985 Jul; 5(7):1940-6. PMID: 4020426.
      View in: PubMed
    30. Heathcote RD, Sargent PB. The genesis and differentiation of neurons in a frog parasympathetic ganglion. Dev Biol. 1984 Sep; 105(1):102-14. PMID: 6468754.
      View in: PubMed
    31. Sargent PB, Hedges BE, Tsavaler L, Clemmons L, Tzartos S, Lindstrom JM. Structure and transmembrane nature of the acetylcholine receptor in amphibian skeletal muscle as revealed by cross-reacting monoclonal antibodies. J Cell Biol. 1984 Feb; 98(2):609-18. PMID: 6363425; PMCID: PMC2113085.
      View in: PubMed, PubMed Central
    32. Sargent PB. The number of synaptic boutons terminating on Xenopus cardiac ganglion cells is directly correlated with cell size. J Physiol. 1983 Oct; 343:85-104. PMID: 6358464; PMCID: PMC1193909.
      View in: PubMed, PubMed Central
    33. Sargent PB, Dennis MJ. The influence of normal innervation upon abnormal synaptic connections between frog parasympathetic neurons. Dev Biol. 1981 Jan 15; 81(1):65-73. PMID: 6161853.
      View in: PubMed
    34. Burden SJ, Sargent PB, McMahan UJ. Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve. J Cell Biol. 1979 Aug; 82(2):412-25. PMID: 479308; PMCID: PMC2110475.
      View in: PubMed, PubMed Central
    35. Dennis MJ, Sargent PB. Loss of extrasynaptic acetylcholine sensitivity upon reinnervation of parasympathetic ganglion cells. J Physiol. 1979 Apr; 289:263-75. PMID: 313439; PMCID: PMC1281369.
      View in: PubMed, PubMed Central
    36. Dennis MJ, Sargent PB. Multiple innervation of normal and re-innervated parasympathetic neurones in the frog cardiac ganglion. J Physiol. 1978 Aug; 281:63-75. PMID: 212557; PMCID: PMC1282684.
      View in: PubMed, PubMed Central
    37. Sargent PB, Dennis MJ. Formation of synapses between parasympathetic neurones deprived of preganglionic innervation. Nature. 1977 Aug 04; 268(5619):456-8. PMID: 197420.
      View in: PubMed
    38. Sargent PB, Yau KW, Nicholls JG. Extrasynaptic receptors on cell bodies of neurons in central nervous system of the leech. J Neurophysiol. 1977 Mar; 40(2):446-52. PMID: 15048.
      View in: PubMed
    39. Sargent PB. Synthesis of acetylcholine by excitatory motoneurons in central nervous system of the leech. J Neurophysiol. 1977 Mar; 40(2):453-60. PMID: 15049.
      View in: PubMed
    40. Berg DK, Kelly RB, Sargent PB, Williamson P, Hall ZW. Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle (snake venom-denervated muscle-neonatal muscle-rat diaphragm-SDS-polyacrylamide gel electrophoresis). Proc Natl Acad Sci U S A. 1972 Jan; 69(1):147-51. PMID: 4333037; PMCID: PMC427564.
      View in: PubMed, PubMed Central
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