Peter Sargent • UCSF Profiles

Peter Sargent, PhD

Title(s)	Professor Emeritus, Cell and Tissue Biology
School	School of Dentistry
Address	513 Parnassus Ave, MSB San Francisco CA 94117
Phone	415-476-6156
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Biography

Education and Training

Amherst College	AB	1969
Harvard University	PhD	1975	Neurobiology
UC San Francisco	postdoctoral	1978	Physiology/School of Medicine
Stanford University	postdoctoral	1979	Neurobiology/School of Medicine

Research

Research Activities and Funding

Nicotinic Synaptic Mechanisms in Chick Ciliary Ganglion
NIH R01MH068690Apr 1, 2007 - Mar 31, 2012
Role: Principal Investigator

PRE &POSTSYNAPTIC NICOTINIC ACHRS--STRUCTURE &FUNCTION
NIH R01MH054251Sep 30, 1996 - Apr 30, 2001
Role: Principal Investigator

NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
NIH R01NS024207Mar 1, 1986 - Dec 31, 2001
Role: Principal Investigator

SYNAPSE FORMATION AND GROWTH IN AN AUTONOMIC GANGLION
NIH R01NS024157Mar 1, 1986 - Feb 28, 1989
Role: Principal Investigator

NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
NIH R01NS022491Sep 1, 1985 - Feb 28, 1986
Role: Principal Investigator

POSTSYNAPTIC PROTEINS AT THE NEUROMUSCULAR JUNCTION
NIH R01NS013521Jul 1, 1977 - Jun 30, 2000
Role: Principal Investigator

ORNG Applications

Academic Senate

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine. J Neurosci. 2011 Oct 19; 31(42):14920-30. Stanchev D, Sargent PB. PMID: 22016525.

View in: PubMed Mentions: 4 Fields:
Neu Neurology
Translation:Animals Cells
Nicotinic receptors concentrated in the subsynaptic membrane do not contribute significantly to synaptic currents at an embryonic synapse in the chicken ciliary ganglion. J Neurosci. 2009 Mar 25; 29(12):3749-59. Sargent PB. PMID: 19321771.

View in: PubMed Mentions: 8 Fields:
Neu Neurology
Translation:Animals Cells
Evolution and revolution: the curriculum reform process at UCSF. J Dent Educ. 2008 Dec; 72(12):1516-30. Ryder MI, Sargent P, Perry D. PMID: 19056631.

View in: PubMed Mentions: 1 Fields:
Den Dentistry Edu Education
Translation:Humans
Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse. J Neurosci. 2005 Sep 07; 25(36):8173-87. Sargent PB, Saviane C, Nielsen TA, DiGregorio DA, Silver RA. PMID: 16148225.

View in: PubMed Mentions: 44 Fields:
Neu Neurology
Translation:Animals Cells
Rapid activation of presynaptic nicotinic acetylcholine receptors by nerve-released transmitter. Eur J Neurosci. 2003 Dec; 18(11):2946-56. Rogers M, Sargent PB. PMID: 14656290.

View in: PubMed Mentions: 4 Fields:
Neu Neurology
Translation:Animals Cells
Synaptic vesicle recycling at two classes of release sites in giant nerve terminals of the embryonic chicken ciliary ganglion. J Comp Neurol. 2002 Jun 24; 448(2):128-37. Nguyen D, Sargent PB. PMID: 12012425.

View in: PubMed Mentions: 5 Fields:
Neu Neurology
Translation:Animals Cells
Properties of nicotinic receptors underlying Renshaw cell excitation by alpha-motor neurons in neonatal rat spinal cord. J Neurophysiol. 2002 Jun; 87(6):3117-25. Dourado M, Sargent PB. PMID: 12037212.

View in: PubMed Mentions: 12 Fields:
Neu Neurology Phy Physiology
Translation:Animals Cells
Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6157-62. Sheets MD, Amersdorfer P, Finnern R, Sargent P, Lindquist E, Schier R, Hemingsen G, Wong C, Gerhart JC, Marks JD, Lindqvist E. PMID: 9600934.

View in: PubMed Mentions: 107 Fields:
Sci Science
Translation:Humans Animals Cells
Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors. J Neurosci. 1997 Oct 01; 17(19):7210-9. Ullian EM, McIntosh JM, Sargent PB. PMID: 9295367.

View in: PubMed Mentions: 26 Fields:
Neu Neurology
Translation:Animals Cells
Effects of denervation on acetylcholine receptor clusters on frog cardiac ganglion neurons as revealed by quantitative laser scanning confocal microscopy. J Neurosci. 1996 Mar 01; 16(5):1720-9. Horch HL, Sargent PB. PMID: 8774440.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals Cells
Synaptic and extrasynaptic distribution of two distinct populations of nicotinic acetylcholine receptor clusters in the frog cardiac ganglion. J Neurocytol. 1996 Jan; 25(1):67-77. Wilson Horch HL, Sargent PB. PMID: 8852939.

View in: PubMed Mentions: 4 Fields:
Cel Cell Biology Neu Neurology
Translation:Animals Cells
Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion. J Neurosci. 1995 Dec; 15(12):7778-95. Horch HL, Sargent PB. PMID: 8613719.

View in: PubMed Mentions: 23 Fields:
Neu Neurology
Translation:Animals Cells
Pronounced cellular diversity and extrasynaptic location of nicotinic acetylcholine receptor subunit immunoreactivities in the chicken pretectum. J Neurosci. 1995 Nov; 15(11):7012-23. Ullian EM, Sargent PB. PMID: 7472457.

View in: PubMed Mentions: 5 Fields:
Neu Neurology
Translation:Animals Cells
The characterization of alpha-bungarotoxin receptors on the surface of parasympathetic neurons in the frog heart. Brain Res. 1995 May 22; 680(1-2):99-107. Sargent PB, Garrett EN. PMID: 7663990.

View in: PubMed Mentions: 2 Fields:
Bra Brain
Translation:Animals Cells
Double-label immunofluorescence with the laser scanning confocal microscope using cyanine dyes. Neuroimage. 1994 Nov; 1(4):288-95. Sargent PB. PMID: 9343578.

View in: PubMed Mentions: 2 Fields:
Dia Diagnostic Imaging
Translation:Animals Cells
The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci. 1993; 16:403-43. Sargent PB. PMID: 7681637.

View in: PubMed Mentions: 158 Fields:
Neu Neurology
Translation:Animals Cells
The role of acetylcholinesterase in denervation supersensitivity in the frog cardiac ganglion. J Physiol. 1992 Jan; 445:249-60. Streichert LC, Sargent PB. PMID: 1501134.

View in: PubMed Mentions: 1 Fields:
Phy Physiology
Translation:Animals
Denervation does not alter the number of neuronal bungarotoxin binding sites on autonomic neurons in the frog cardiac ganglion. J Neurosci. 1991 Nov; 11(11):3610-23. Sargent PB, Bryan GK, Streichert LC, Garrett EN. PMID: 1941098.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Animals Cells
Differential effects of denervation on acetylcholinesterase activity in parasympathetic and sympathetic ganglia of the frog, Rana pipiens. J Neurobiol. 1990 Sep; 21(6):938-49. Streichert LC, Sargent PB. PMID: 2077105.

View in: PubMed Mentions: 1 Fields:
Bio Biology Neu Neurology
Translation:Animals
Acetylcholine receptor-like molecules are found in both synaptic and extrasynaptic clusters on the surface of neurons in the frog cardiac ganglion. J Neurosci. 1989 Mar; 9(3):1062-72. Sargent PB, Pang DZ. PMID: 2784494.

View in: PubMed Mentions: 7 Fields:
Neu Neurology
Translation:Animals Cells
Bouton ultrastructure and synaptic growth in a frog autonomic ganglion. J Comp Neurol. 1989 Mar 01; 281(1):159-68. Streichert LC, Sargent PB. PMID: 2925900.

View in: PubMed Mentions: 4 Fields:
Neu Neurology
Translation:Animals Cells
Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog. J Neurosci. 1989 Feb; 9(2):565-73. Sargent PB, Pike SH, Nadel DB, Lindstrom JM. PMID: 2645388.

View in: PubMed Mentions: 12 Fields:
Neu Neurology
Translation:Animals Cells
Denervation alters the size, number, and distribution of clusters of acetylcholine receptor-like molecules on frog cardiac ganglion neurons. Neuron. 1988 Nov; 1(9):877-86. Sargent PB, Pang DZ. PMID: 3272191.

View in: PubMed Mentions: 4 Fields:
Neu Neurology
Translation:Animals
Growth and morphogenesis of an autonomic ganglion. I. Matching neurons with target. J Neurosci. 1987 Aug; 7(8):2493-501. Heathcote RD, Sargent PB. PMID: 3612250.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Animals Cells
Growth and morphogenesis of an autonomic ganglion. II. Establishment of neuron position. J Neurosci. 1987 Aug; 7(8):2502-9. Heathcote RD, Sargent PB. PMID: 3612251.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals Cells
Using monoclonal antibodies to determine the structures of acetylcholine receptors from electric organs, muscles, and neurons. Ann N Y Acad Sci. 1987; 505:208-25. Lindstrom J, Criado M, Ratnam M, Whiting P, Ralston S, Rivier J, Sarin V, Sargent P. PMID: 2446548.

View in: PubMed Mentions: 4 Fields:
Sci Science
Translation:Animals Cells
Transmembrane topography of nicotinic acetylcholine receptor: immunochemical tests contradict theoretical predictions based on hydrophobicity profiles. Biochemistry. 1986 May 06; 25(9):2633-43. Ratnam M, Nguyen DL, Rivier J, Sargent PB, Lindstrom J. PMID: 3718969.

View in: PubMed Mentions: 30 Fields:
Bio Biochemistry
Translation:Animals Cells
Location of antigenic determinants on primary sequences of subunits of nicotinic acetylcholine receptor by peptide mapping. Biochemistry. 1986 May 06; 25(9):2621-32. Ratnam M, Sargent PB, Sarin V, Fox JL, Nguyen DL, Rivier J, Criado M, Lindstrom J. PMID: 2424498.

View in: PubMed Mentions: 23 Fields:
Bio Biochemistry
Translation:Animals Cells
Loss of supernumerary axons during neuronal morphogenesis. J Neurosci. 1985 Jul; 5(7):1940-6. Heathcote RD, Sargent PB. PMID: 4020426.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Animals Cells
The genesis and differentiation of neurons in a frog parasympathetic ganglion. Dev Biol. 1984 Sep; 105(1):102-14. Heathcote RD, Sargent PB. PMID: 6468754.

View in: PubMed Mentions: 1 Fields:
Bio Biology Emb Embryology
Translation:Animals Cells
Structure and transmembrane nature of the acetylcholine receptor in amphibian skeletal muscle as revealed by cross-reacting monoclonal antibodies. J Cell Biol. 1984 Feb; 98(2):609-18. Sargent PB, Hedges BE, Tsavaler L, Clemmons L, Tzartos S, Lindstrom JM. PMID: 6363425.

View in: PubMed Mentions: 22 Fields:
Cel Cell Biology
Translation:Animals Cells
The number of synaptic boutons terminating on Xenopus cardiac ganglion cells is directly correlated with cell size. J Physiol. 1983 Oct; 343:85-104. Sargent PB. PMID: 6358464.

View in: PubMed Mentions: 4 Fields:
Phy Physiology
Translation:Animals Cells
The influence of normal innervation upon abnormal synaptic connections between frog parasympathetic neurons. Dev Biol. 1981 Jan 15; 81(1):65-73. Sargent PB, Dennis MJ. PMID: 6161853.

View in: PubMed Mentions: 7 Fields:
Bio Biology Emb Embryology
Translation:Animals Cells
Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve. J Cell Biol. 1979 Aug; 82(2):412-25. Burden SJ, Sargent PB, McMahan UJ. PMID: 479308.

View in: PubMed Mentions: 77 Fields:
Cel Cell Biology
Translation:Animals
Loss of extrasynaptic acetylcholine sensitivity upon reinnervation of parasympathetic ganglion cells. J Physiol. 1979 Apr; 289:263-75. Dennis MJ, Sargent PB. PMID: 313439.

View in: PubMed Mentions: 8 Fields:
Phy Physiology
Translation:Animals Cells
Multiple innervation of normal and re-innervated parasympathetic neurones in the frog cardiac ganglion. J Physiol. 1978 Aug; 281:63-75. Dennis MJ, Sargent PB. PMID: 212557.

View in: PubMed Mentions: 5 Fields:
Phy Physiology
Translation:Animals Cells
Formation of synapses between parasympathetic neurones deprived of preganglionic innervation. Nature. 1977 Aug 04; 268(5619):456-8. Sargent PB, Dennis MJ. PMID: 197420.

View in: PubMed Mentions: 11 Fields:
Sci Science
Translation:Animals Cells
Extrasynaptic receptors on cell bodies of neurons in central nervous system of the leech. J Neurophysiol. 1977 Mar; 40(2):446-52. Sargent PB, Yau KW, Nicholls JG. PMID: 15048.

View in: PubMed Mentions:
Synthesis of acetylcholine by excitatory motoneurons in central nervous system of the leech. J Neurophysiol. 1977 Mar; 40(2):453-60. Sargent PB. PMID: 15049.

View in: PubMed Mentions:
Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle (snake venom-denervated muscle-neonatal muscle-rat diaphragm-SDS-polyacrylamide gel electrophoresis). Proc Natl Acad Sci U S A. 1972 Jan; 69(1):147-51. Berg DK, Kelly RB, Sargent PB, Williamson P, Hall ZW. PMID: 4333037.

View in: PubMed Mentions: 71 Fields:
Sci Science
Translation:Animals Cells