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Erik Ullian, PhD

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Phone415-476-1314
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1997 Graduate Division (Neuroscience)
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

    Collapse Research 
    Collapse Research Activities and Funding
    Developing astrocyte, neuron, and microglial 3D organoids to model key aspects of human pathology
    NIH/NIA R03AG063157Apr 1, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Investigating Astrocyte Diversity and Function in Midbrain Dopaminergic Circuits
    NIH/NIMH R01MH099595Dec 20, 2012 - Nov 30, 2015
    Role: Principal Investigator
    THE ROLE OF ASTROCYTES IN PLASTICITY AND DISEASE.
    NIH DP2OD006507Sep 30, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Role of Micro-RNAs in Neuronal Circuit Formation and Function
    NIH/NIMH R21MH083090Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    PRESYNAPTIC GLIAL ENHANCEMENT OF SYNAPTIC EFFICACY
    NIH/NINDS F32NS010784Jun 1, 1999
    Role: Principal Investigator
    P30 - Core Grant for Vision Research
    NIH/NEI P30EY002162Dec 1, 1977 - Nov 30, 1992
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA. CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. Genome Biol. 2020 Mar 31; 21(1):83. PMID: 32234056.
      View in: PubMed
    2. Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH. Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map. Nat Neurosci. 2020 Apr; 23(4):500-509. PMID: 32203496.
      View in: PubMed
    3. de Majo M, Koontz M, Rowitch D, Ullian EM. An update on human astrocytes and their role in development and disease. Glia. 2020 Apr; 68(4):685-704. PMID: 31926040.
      View in: PubMed
    4. S John Liu, Martina Malatesta, Kyounghee Seo, Brian Lien, Sung Hong, Mark Koontz, David Raleigh, Erik Ullian, Daniel Lim. GENE-39. CRISPRi-BASED RADIATION MODIFIER SCREEN IDENTIFIES LONG NON-CODING RNA THERAPEUTIC TARGETS IN GLIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi106-vi106.
      View in: Publisher Site
    5. Stephen Magill, Harish Vasudevan, Kyounghee Seo, S John Liu, Stephanie Hilz, Javier Villanueva-Meyer, Abrar Choudhury, Benjamin Demaree, Daniel Lim, Steve Braunstein, Nancy Ann Oberheim-Bush, Erik Ullian, Manish Aghi, Philip Theodosopoulos, Patricia Sneed, Adam Abate, Mitchel Berger, Mike McDermott, Joseph Costello, David Raleigh. TMOD-27. A NEURAL CREST CELL SUBPOPULATION UNDERLIES INTRATUMOR HETEROGENEITY IN MENINGIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi268-vi268.
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    6. Labelle-Dumais C, Schuitema V, Hayashi G, Hoff K, Gong W, Dao DQ, Ullian EM, Oishi P, Margeta M, Gould DB. COL4A1 Mutations Cause Neuromuscular Disease with Tissue-Specific Mechanistic Heterogeneity. Am J Hum Genet. 2019 05 02; 104(5):847-860. PMID: 31051113.
      View in: PubMed
    7. Martina Malatesta, John Liu, Leslie Pedraza, Kyounghee Seo, Elizabeth DiLullo, David Raleigh, Arnold Kriegstein, Erik Ullian, Daniel Lim. TMOD-04. TARGETING A GLIOMA SPECIFIC lncRNA IN A HUMAN BRAIN ORGANOID TUMOR MODEL. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi269-vi269.
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    8. Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F. Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. Am J Med Genet A. 2018 12; 176(12):2924-2929. PMID: 30302932.
      View in: PubMed
    9. Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018 04 18; 98(2):306-319.e7. PMID: 29606582.
      View in: PubMed
    10. Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ. Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury. Brain. 2018 01 01; 141(1):85-98. PMID: 29244098.
      View in: PubMed
    11. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 05; 21(10):2678-2687. PMID: 29212016.
      View in: PubMed
    12. Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM. Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Stem Cell Reports. 2017 12 12; 9(6):1745-1753. PMID: 29198827.
      View in: PubMed
    13. Yeh E, Dao DQ, Wu ZY, Kandalam SM, Camacho FM, Tom C, Zhang W, Krencik R, Rauen KA, Ullian EM, Weiss LA. Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. Mol Psychiatry. 2018 08; 23(8):1687-1698. PMID: 29158583.
      View in: PubMed
    14. Krejciova Z, Alibhai J, Zhao C, Krencik R, Rzechorzek NM, Ullian EM, Manson J, Ironside JW, Head MW, Chandran S. Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. J Exp Med. 2017 Dec 04; 214(12):3481-3495. PMID: 29141869.
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    15. Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein AR, DeRisi JL. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):14408-14413. PMID: 27911847.
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    16. Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L. Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension. J Neurosci. 2016 08 31; 36(35):9240-52. PMID: 27581463.
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    17. Krencik R, van Asperen JV, Ullian EM. Human astrocytes are distinct contributors to the complexity of synaptic function. Brain Res Bull. 2017 03; 129:66-73. PMID: 27570101.
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    18. Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss LA, Rauen KA, Sobie EA, Gelb BD. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2016 09 13; 7(3):355-369. PMID: 27569062.
      View in: PubMed
    19. Etxeberria A, Hokanson KC, Dao DQ, Mayoral SR, Mei F, Redmond SA, Ullian EM, Chan JR. Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity. J Neurosci. 2016 06 29; 36(26):6937-48. PMID: 27358452.
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    20. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 06; 36(1):142-52. PMID: 26740656.
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    21. Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss LA, Rowitch DH, Ullian EM. Dysregulation of astrocyte extracellular signaling in Costello syndrome. Sci Transl Med. 2015 May 06; 7(286):286ra66. PMID: 25947161.
      View in: PubMed
    22. Shen YA, Chen Y, Dao DQ, Mayoral SR, Wu L, Meijer D, Ullian EM, Chan JR, Lu QR. Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent. Nat Commun. 2014 Sep 26; 5:4991. PMID: 25255972.
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    23. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. PMID: 24776795.
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    24. Krencik R, Ullian EM. A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies. Front Cell Neurosci. 2013; 7:25. PMID: 23503583.
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    25. Hsu R, Schofield CM, Dela Cruz CG, Jones-Davis DM, Blelloch R, Ullian EM. Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex. Mol Cell Neurosci. 2012 Jul; 50(3-4):283-92. PMID: 22728723.
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    26. Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 01; 26(9):891-907. PMID: 22549954.
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    27. Beaudoin GM, Schofield CM, Nuwal T, Zang K, Ullian EM, Huang B, Reichardt LF. Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus. J Neurosci. 2012 Jan 04; 32(1):99-110. PMID: 22219273.
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    28. Koch SM, Dela Cruz CG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron. 2011 Jul 28; 71(2):235-42. PMID: 21791283.
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    29. Babiarz JE, Hsu R, Melton C, Thomas M, Ullian EM, Blelloch R. A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing. RNA. 2011 Aug; 17(8):1489-501. PMID: 21712401.
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    30. Schofield CM, Hsu R, Barker AJ, Gertz CC, Blelloch R, Ullian EM. Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex. Neural Dev. 2011 Apr 05; 6:11. PMID: 21466685.
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    31. S.M. Koch, E.M. Ullian. Chapter 39 Development of Retinogeniculate Projections. Adler\u0027s Physiology of the Eye. 2011 Jan 1; 725-731.
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    32. Koch SM, Ullian EM. Neuronal pentraxins mediate silent synapse conversion in the developing visual system. J Neurosci. 2010 Apr 14; 30(15):5404-14. PMID: 20392962.
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    33. Okerlund ND, Kivimäe S, Tong CK, Peng IF, Ullian EM, Cheyette BN. Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J Neurosci. 2010 Mar 24; 30(12):4362-8. PMID: 20335472.
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    34. Barker AJ, Ullian EM. Astrocytes and synaptic plasticity. Neuroscientist. 2010 Feb; 16(1):40-50. PMID: 20236948.
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    35. Arikkath J, Peng IF, Ng YG, Israely I, Liu X, Ullian EM, Reichardt LF. Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development. J Neurosci. 2009 Apr 29; 29(17):5435-42. PMID: 19403811.
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    36. Lee SH, Peng IF, Ng YG, Yanagisawa M, Bamji SX, Elia LP, Balsamo J, Lilien J, Anastasiadis PZ, Ullian EM, Reichardt LF. Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin. J Cell Biol. 2008 Dec 01; 183(5):893-908. PMID: 19047464.
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    37. I. Feng. Peng, S-H. Lee, L. Reichardt, E. Ullian. Functional regulations of p120 catenin at presynaptic site in neuron cultures. International Journal of Developmental Neuroscience. 2008 Dec 1; 26(8):841.
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    38. E. Ullian. Neuronal pentraxins mediate silent synapse conversion in the developing visual system. International Journal of Developmental Neuroscience. 2008 Dec 1; 26(8):839.
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    39. Huberman AD, Manu M, Koch SM, Susman MW, Lutz AB, Ullian EM, Baccus SA, Barres BA. Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells. Neuron. 2008 Aug 14; 59(3):425-38. PMID: 18701068.
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    40. Barker AJ, Koch SM, Reed J, Barres BA, Ullian EM. Developmental control of synaptic receptivity. J Neurosci. 2008 Aug 13; 28(33):8150-60. PMID: 18701677.
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    41. Davis TH, Cuellar TL, Koch SM, Barker AJ, Harfe BD, McManus MT, Ullian EM. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci. 2008 Apr 23; 28(17):4322-30. PMID: 18434510.
      View in: PubMed
    42. Cuellar TL, Davis TH, Nelson PT, Loeb GB, Harfe BD, Ullian E, McManus MT. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5614-9. PMID: 18385371.
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    43. Barker AJ, Ullian EM. New roles for astrocytes in developing synaptic circuits. Commun Integr Biol. 2008; 1(2):207-11. PMID: 19513261.
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    44. Bjartmar L, Huberman AD, Ullian EM, Rentería RC, Liu X, Xu W, Prezioso J, Susman MW, Stellwagen D, Stokes CC, Cho R, Worley P, Malenka RC, Ball S, Peachey NS, Copenhagen D, Chapman B, Nakamoto M, Barres BA, Perin MS. Neuronal pentraxins mediate synaptic refinement in the developing visual system. J Neurosci. 2006 Jun 07; 26(23):6269-81. PMID: 16763034.
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    45. Erik M. Ullian, Alexander Dityatev. Extracellular Matrix Molecules and Formation of CNS Synapses. Molecular Mechanisms of Synaptogenesis. 2006 Jan 1; 163-178.
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    46. Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell. 2005 Feb 11; 120(3):421-33. PMID: 15707899.
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    47. Ullian EM, Christopherson KS, Barres BA. Role for glia in synaptogenesis. Glia. 2004 Aug 15; 47(3):209-16. PMID: 15252809.
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    48. Ullian EM, Barkis WB, Chen S, Diamond JS, Barres BA. Invulnerability of retinal ganglion cells to NMDA excitotoxicity. Mol Cell Neurosci. 2004 Aug; 26(4):544-57. PMID: 15276156.
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    49. Ullian EM, Harris BT, Wu A, Chan JR, Barres BA. Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture. Mol Cell Neurosci. 2004 Feb; 25(2):241-51. PMID: 15019941.
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    50. Kaplan MR, Cho MH, Ullian EM, Isom LL, Levinson SR, Barres BA. Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron. 2001 Apr; 30(1):105-19. PMID: 11343648.
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    51. Ullian EM, Sapperstein SK, Christopherson KS, Barres BA. Control of synapse number by glia. Science. 2001 Jan 26; 291(5504):657-61. PMID: 11158678.
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    52. Ullian EM, Barres BA. The Schwann song of the glia-less synapse. Neuron. 1998 Oct; 21(4):651-2. PMID: 9808449.
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    53. Ullian EM, McIntosh JM, Sargent PB. Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors. J Neurosci. 1997 Oct 01; 17(19):7210-9. PMID: 9295367.
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    54. Ullian EM, Sargent PB. Pronounced cellular diversity and extrasynaptic location of nicotinic acetylcholine receptor subunit immunoreactivities in the chicken pretectum. J Neurosci. 1995 Nov; 15(11):7012-23. PMID: 7472457.
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    55. P. B. Sargent, H. L. Wilson, E. M. Ullian, Reinhard Marks, John Lindstrom, Hannsjórg Schröder, M. Piattoni-Kaplan, D. Donnelly-Roberts, J. Pauly, D. Hill, J. B. Pan, S. P. Arneric, J. P. Sullivan, I. Aubert, D. Cécyre, S. Gauthier, R. Ouirion. Receptor localization. International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II. 1994 Jan 1; 71:21-22.
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