Marcus Muench, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address3333 California Street
San Francisco CA 94118
ORCID ORCID Icon0000-0001-8946-6605 Additional info
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    Research in my laboratory is focused on the early development of human tissue-specific stem cells. Mostly my laboratory studies cells of the fetal liver to better understand hematopoietic, immune and hepatic development. Both hematopoietic and hepatic tissues share the same organ during fetal development but are considered to arise from separate embryological tissues. Our work has helped to identify hematopoietic and hepatic progenitor populations in the liver and some of the cytokines that regulate their growth. A driving force behind my basic research efforts is a desire for the research to be clinically applicable, particularly in the field of fetal therapy. Fetal cellular therapy, the transplantation of cells into a fetus, has the potential of ameliorating or curing a large number of birth defects. However, the current practice of in utero stem cell transplantation is not yet effective enough to treat most hematopoietic or hepatic birth defects. Work in my laboratory is using mouse models of in utero transplantation to study methods of improving engraftment of foreign cells by prenatal transplantation.

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    Development of iPS Cells for Treatment of Hemoglobinopathies
    NIH P01DK088760Sep 30, 2011 - Jul 31, 2017
    Role: Co-Investigator
    Ontogenic changes in erythroid gene expression
    NIH R21DK068441Sep 30, 2004 - Aug 31, 2006
    Role: Principal Investigator
    Fetal Stem Cell Gene Therapy
    NIH K01DK059301Sep 1, 2001 - Aug 31, 2004
    Role: Principal Investigator
    NIH P01HL053762Sep 30, 1994 - Aug 31, 2007
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-ß expression by cDCs and monocytes in mice. Blood Adv. 2020 Nov 10; 4(21):5547-5561. Tran JQ, Muench MO, Jackman RP. PMID: 33166410.
      View in: PubMed   Mentions:    Fields:    
    2. Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress. Transfusion. 2020 Nov 04. Hazegh K, Fang F, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, D'Alessandro A, Dumont L, Page GP, Kanias T. PMID: 33146433.
      View in: PubMed   Mentions:    Fields:    
    3. µ-Lat: A mouse model to evaluate human immunodeficiency virus eradication strategies. FASEB J. 2020 Nov; 34(11):14615-14630. Sperber HS, Togarrati PP, Raymond KA, Bouzidi MS, Gilfanova R, Gutierrez AG, Muench MO, Pillai SK. PMID: 32901981.
      View in: PubMed   Mentions:    Fields:    
    4. Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice. PLoS One. 2020; 15(7):e0237106. Blessinger SA, Tran JQ, Jackman RP, Gilfanova R, Rittenhouse J, Gutierrez AG, Heitman JW, Hazegh K, Kanias T, Muench MO. PMID: 32735605.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. A small allelic variant in donor class I MHC is sufficient to induce alloantibodies following transfusion of standard or pathogen-reduced platelets in mice. Vox Sang. 2020 Jul; 115(5):367-376. Jackman RP, Heitman JW, Muench MO. PMID: 32201962.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Pathogen reduction with riboflavin and ultraviolet light induces a quasi-apoptotic state in blood leukocytes. Transfusion. 2019 11; 59(11):3501-3510. Tran JQ, Muench MO, Heitman JW, Jackman RP. PMID: 31599981.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    7. Potential of Membranes Surrounding the Fetus as Immunoprotective Cell-Carriers for Allogeneic Transplantations. Transplant Direct. 2019 Jun; 5(6):e460. Togarrati PP, Dinglasan N, Yee E, Heitman JW, Jackman RP, Geisberg M, Norris PJ, Bárcena A, Muench MO. PMID: 31321294.
      View in: PubMed   Mentions:
    8. Allogeneic major histocompatibility complex antigens are necessary and sufficient for partial tolerance induced by transfusion of pathogen reduced platelets in mice. Vox Sang. 2019 Apr; 114(3):207-215. Tran JQ, Muench MO, Heitman JW, Jackman RP. PMID: 30734299.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage. Development. 2018 11 05; 145(21). May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM. PMID: 30305288.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    10. Minimal infectious dose and dynamics of Babesia microti parasitemia in a murine model. Transfusion. 2018 12; 58(12):2903-2910. Bakkour S, Chafets DM, Wen L, Muench MO, Telford SR, Erwin JL, Levin AE, Self D, Brès V, Linnen JM, Lee TH, Busch MP. PMID: 30264498.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope. PLoS Negl Trop Dis. 2018 07; 12(7):e0006693. Jin J, Sherman MB, Chafets D, Dinglasan N, Lu K, Lee TH, Carlson LA, Muench MO, Simmons G. PMID: 30063703.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. CD29 is highly expressed on epithelial, myoepithelial, and mesenchymal stromal cells of human salivary glands. Oral Dis. 2018 May; 24(4):561-572. Togarrati PP, Dinglasan N, Desai S, Ryan WR, Muench MO. PMID: 29197149.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2180-2185. Tan YT, Ye L, Xie F, Beyer AI, Muench MO, Wang J, Chen Z, Liu H, Chen SJ, Kan YW. PMID: 29386396.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Human fetal liver cultures support multiple cell lineages that can engraft immunodeficient mice. Open Biol. 2017 12; 7(12). Fomin ME, Beyer AI, Muench MO. PMID: 29237808.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. SOX2 regulates acinar cell development in the salivary gland. Elife. 2017 06 17; 6. Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM. PMID: 28623666.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands. Sci Rep. 2017 06 14; 7(1):3484. Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO. PMID: 28615711.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation. Development. 2017 04 15; 144(8):1399-1411. Muench MO, Kapidzic M, Gormley M, Gutierrez AG, Ponder KL, Fomin ME, Beyer AI, Stolp H, Qi Z, Fisher SJ, Bárcena A. PMID: 28255007.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. A cost-effective software solution for vivarium management. Lab Anim (NY). 2016 Dec 19; 46(1):17-20. Muench MO. PMID: 27991870.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Higher Serum Alanine Transaminase Levels in Male Urokinase-Type Plasminogen Activator-Transgenic Mice Are Associated With Improved Engraftment of Hepatocytes but not Liver Sinusoidal Endothelial Cells. Cell Med. 2017; 9(3):117-125. Fomin ME, Beyer AI, Publicover J, Lu K, Bakkour S, Simmons G, Muench MO. PMID: 28713641.
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    20. Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood. Transfusion. 2017 02; 57(2):337-348. Jackman RP, Muench MO, Inglis H, Heitman JW, Marschner S, Goodrich RP, Norris PJ. PMID: 27859333.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    21. Comparison of Human Hematopoietic Reconstitution in Different Strains of Immunodeficient Mice. Stem Cells Dev. 2017 01 15; 26(2):102-112. Beyer AI, Muench MO. PMID: 27758159.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and ß-thalassemia. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10661-5. Ye L, Wang J, Tan Y, Beyer AI, Xie F, Muench MO, Kan YW. PMID: 27601644.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    23. Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets. Transfusion. 2016 06; 56(6):1419-29. Muench MO, Heitman JW, Inglis H, Fomin ME, Marschner S, Goodrich RP, Norris PJ, Jackman RP. PMID: 27028210.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    24. The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function. Transfusion. 2016 Mar; 56 Suppl 1:S52-64. Baimukanova G, Miyazawa B, Potter DR, Gibb SL, Keating S, Danesh A, Beyer A, Dayter Y, Bruhn R, Muench MO, Cap AP, Norris PJ, Spinella P, Cohen M, Pati S. PMID: 27001362.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    25. Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets. Transfusion. 2016 Mar; 56 Suppl 1:S65-75. Baimukanova G, Miyazawa B, Potter DR, Muench MO, Bruhn R, Gibb SL, Spinella PC, Cap AP, Cohen MJ, Pati S. PMID: 27001364.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    26. TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs. Mol Ther Nucleic Acids. 2016 Jan 05; 5:e273. Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M, Porteus MH, Shuto T, Kai H, Kan YW, Gruenert DC. PMID: 26730810.
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    27. A diverse group of small circular ssDNA viral genomes in human and non-human primate stools. Virus Evol. 2015; 1(1):vev017. Ng TF, Zhang W, Sachsenröder J, Kondov NO, da Costa AC, Vega E, Holtz LR, Wu G, Wang D, Stine CO, Antonio M, Mulvaney US, Muench MO, Deng X, Ambert-Balay K, Pothier P, Vinjé J, Delwart E. PMID: 27774288.
      View in: PubMed   Mentions:
    28. Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis. Cell Rep. 2015 Dec 22; 13(11):2553-2564. Jin J, Liss NM, Chen DH, Liao M, Fox JM, Shimak RM, Fong RH, Chafets D, Bakkour S, Keating S, Fomin ME, Muench MO, Sherman MB, Doranz BJ, Diamond MS, Simmons G. PMID: 26686638.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    29. A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros. Leukemia. 2016 05; 30(5):1194-7. Wiemels JL, de Smith AJ, Xiao J, Lee ST, Muench MO, Fomin ME, Zhou M, Hansen HM, Termuhlen A, Metayer C, Walsh KM. PMID: 26437776.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal-bone marrow: a simple and rapid method for the isolation of mouse central bone marrow. BMC Hematol. 2015; 15:9. Mahajan MM, Cheng B, Beyer AI, Mulvaney US, Wilkinson MB, Fomin ME, Muench MO. PMID: 26161262.
      View in: PubMed   Mentions:
    31. Whole-genome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet. 2015 Jul; 47(7):746-56. Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Pascual M, Agirre X, Prosper F, Alignani D, Paiva B, Caron G, Fest T, Muench MO, Fomin ME, Lee ST, Wiemels JL, Valencia A, Gut M, Flicek P, Stunnenberg HG, Siebert R, Küppers R, Gut IG, Campo E, Martín-Subero JI. PMID: 26053498.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    32. Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S7-S17. Potter DR, Baimukanova G, Keating SM, Deng X, Chu JA, Gibb SL, Peng Z, Muench MO, Fomin ME, Spinella PC, Kozar R, Pati S. PMID: 26002267.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    33. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602. Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL. PMID: 25690899.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Potential role of increased oxygenation in altering perinatal adrenal steroidogenesis. Pediatr Res. 2015 Feb; 77(2):298-309. Agrawal V, Tee MK, Qiao J, Muench MO, Miller WL. PMID: 25470028.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Progress and challenges in the development of a cell-based therapy for hemophilia A. J Thromb Haemost. 2014 Dec; 12(12):1954-65. Fomin ME, Togarrati PP, Muench MO. PMID: 25297648.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    36. Exposure of epitope residues on the outer face of the chikungunya virus envelope trimer determines antibody neutralizing efficacy. J Virol. 2014 Dec; 88(24):14364-79. Fong RH, Banik SS, Mattia K, Barnes T, Tucker D, Liss N, Lu K, Selvarajah S, Srinivasan S, Mabila M, Miller A, Muench MO, Michault A, Rucker JB, Paes C, Simmons G, Kahle KM, Doranz BJ. PMID: 25275138.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    37. Seamless gene correction of ß-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac. Genome Res. 2014 Sep; 24(9):1526-33. Xie F, Ye L, Chang JC, Beyer AI, Wang J, Muench MO, Kan YW. PMID: 25096406.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    38. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5?32 mutation confers resistance to HIV infection. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9591-6. Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW. PMID: 24927590.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    39. The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny. PLoS One. 2014; 9(5):e97312. Muench MO, Beyer AI, Fomin ME, Thakker R, Mulvaney US, Nakamura M, Suemizu H, Bárcena A. PMID: 24819392.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    40. Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro. Blood. 2014 Jan 30; 123(5):687-96. Danesh A, Inglis HC, Jackman RP, Wu S, Deng X, Muench MO, Heitman JW, Norris PJ. PMID: 24335232.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    41. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS One. 2013; 8(10):e77255. Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO. PMID: 24167566.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    42. A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease. PLoS Negl Trop Dis. 2013; 7(9):e2423. Selvarajah S, Sexton NR, Kahle KM, Fong RH, Mattia KA, Gardner J, Lu K, Liss NM, Salvador B, Tucker DF, Barnes T, Mabila M, Zhou X, Rossini G, Rucker JB, Sanders DA, Suhrbier A, Sambri V, Michault A, Muench MO, Doranz BJ, Simmons G. PMID: 24069479.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    43. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. PMID: 23925290.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    44. Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors. Stem Cells Transl Med. 2013 Aug; 2(8):558-66. Ye L, Muench MO, Fusaki N, Beyer AI, Wang J, Qi Z, Yu J, Kan YW. PMID: 23847002.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    45. Identification of an astrovirus commonly infecting laboratory mice in the US and Japan. PLoS One. 2013; 8(6):e66937. Ng TF, Kondov NO, Hayashimoto N, Uchida R, Cha Y, Beyer AI, Wong W, Pesavento PA, Suemizu H, Muench MO, Delwart E. PMID: 23825590.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    46. Immune modulation and lack of alloimmunization following transfusion with pathogen-reduced platelets in mice. Transfusion. 2013 Nov; 53(11):2697-709. Jackman RP, Muench MO, Heitman JW, Inglis HC, Law JP, Marschner S, Goodrich RP, Norris PJ. PMID: 23451715.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Filoviruses utilize glycosaminoglycans for their attachment to target cells. J Virol. 2013 Mar; 87(6):3295-304. Salvador B, Sexton NR, Carrion R, Nunneley J, Patterson JL, Steffen I, Lu K, Muench MO, Lembo D, Simmons G. PMID: 23302881.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    48. A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res. 2012 Dec; 40(22):11339-51. Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, Zheng S, Dou X, de Smith A, Chokkalingam A, Buffler P, Ma X, Wiemels JL. PMID: 23074194.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    49. Distinct roles of trauma and transfusion in induction of immune modulation after injury. Transfusion. 2012 Dec; 52(12):2533-50. Jackman RP, Utter GH, Muench MO, Heitman JW, Munz MM, Jackman RW, Biswas HH, Rivers RM, Tobler LH, Busch MP, Norris PJ. PMID: 22452342.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    50. Expression of P450c17 in the human fetal nervous system. Endocrinology. 2012 May; 153(5):2494-505. Schonemann MD, Muench MO, Tee MK, Miller WL, Mellon SH. PMID: 22434081.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    51. Cellular therapies supplement: the peritoneum as an ectopic site of hematopoiesis following in utero transplantation. Transfusion. 2011 Nov; 51 Suppl 4:106S-117S. Muench MO, Chen JC, Beyer AI, Fomin ME. PMID: 22074621.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    52. Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation. Transfusion. 2011 Nov; 51 Suppl 4:94S-105S. Bárcena A, Muench MO, Kapidzic M, Gormley M, Goldfien GA, Fisher SJ. PMID: 22074633.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    53. Maternal microchimerism in pediatric inflammatory bowel disease. Chimerism. 2011 Apr; 2(2):50-4. Suskind DL, Kong D, Stevens A, Wahbeh G, Christie D, Baxter-Lowe LA, Muench MO. PMID: 21912719.
      View in: PubMed   Mentions: 4     Fields:    
    54. Coexpression of CD14 and CD326 discriminate hepatic precursors in the human fetal liver. Stem Cells Dev. 2011 Jul; 20(7):1247-57. Fomin ME, Tai LK, Bárcena A, Muench MO. PMID: 20964518.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    55. Detection of human hematopoietic stem cell engraftment in the livers of adult immunodeficient mice by an optimized flow cytometric method. Stem Cell Stud. 2010 Nov 23; 1(1). Varga NL, Bárcena A, Fomin ME, Muench MO. PMID: 21603093.
      View in: PubMed   Mentions:
    56. Characterization of tolerance induction through prenatal marrow transplantation: the requirement for a threshold level of chimerism to establish rather than maintain postnatal skin tolerance. Cell Transplant. 2010; 19(12):1609-22. Chen JC, Kuo ML, Ou LS, Chang PY, Muench MO, Shen CR, Chang HL, Yu HY, Fu RH. PMID: 20719075.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    57. Barley as a green factory for the production of functional Flt3 ligand. Biotechnol J. 2010 Feb; 5(2):163-71. Erlendsson LS, Muench MO, Hellman U, Hrafnkelsdóttir SM, Jonsson A, Balmer Y, Mäntylä E, Orvar BL. PMID: 19844912.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    58. Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J Virol. 2010 Jan; 84(2):1198-205. Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, Pöhlmann S. PMID: 19864379.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    59. Characterization of Chikungunya pseudotyped viruses: Identification of refractory cell lines and demonstration of cellular tropism differences mediated by mutations in E1 glycoprotein. Virology. 2009 Oct 10; 393(1):33-41. Salvador B, Zhou Y, Michault A, Muench MO, Simmons G. PMID: 19692105.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    60. A new role for the human placenta as a hematopoietic site throughout gestation. Reprod Sci. 2009 Feb; 16(2):178-87. Bárcena A, Muench MO, Kapidzic M, Fisher SJ. PMID: 19208786.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    61. Transplantation NK'Oed in the first trimester. Blood. 2008 Dec 15; 112(13):4790-1. Muench MO. PMID: 19064738.
      View in: PubMed   Mentions:    Fields:    
    62. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008 Dec 05; 322(5907):1562-5. Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM. PMID: 19056990.
      View in: PubMed   Mentions: 298     Fields:    Translation:HumansCells
    63. Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J Immunol. 2008 Nov 15; 181(10):6850-8. Drake PM, Nathan JK, Stock CM, Chang PV, Muench MO, Nakata D, Reader JR, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Troy FA, Bertozzi CR. PMID: 18981104.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    64. Prenatal tolerance induction: relationship between cell dose, marrow T-cells, chimerism, and tolerance. Cell Transplant. 2008; 17(5):495-506. Chen JC, Chang ML, Huang SF, Chang PY, Muench MO, Fu RH, Ou LS, Kuo ML. PMID: 18714669.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    65. Persistence of allografts in the peritoneal cavity after prenatal transplantation in mice. Transfusion. 2008 Mar; 48(3):553-60. Chen JC, Chang ML, Muench MO. PMID: 18067493.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    66. Midkine, a heparin-binding growth factor, selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland. J Clin Endocrinol Metab. 2006 Oct; 91(10):4050-6. Ishimoto H, Muench MO, Higuchi T, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB. PMID: 16895951.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    67. Maintenance of proliferative capacity and retroviral transduction efficiency of human fetal CD38(-)/CD34(++) stem cells. Stem Cells Dev. 2006 Feb; 15(1):97-108. Muench MO, Ohkubo T, Smith CA, Suskind DL, Bárcena A. PMID: 16522167.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    68. In utero transplantation: baby steps towards an effective therapy. Bone Marrow Transplant. 2005 Mar; 35(6):537-47. Muench MO. PMID: 15665844.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    69. Prevention of graft rejection by donor type II CD8(+) T cells (Tc2 cells) is not sufficient to improve engraftment in fetal transplantation. Fetal Diagn Ther. 2005 Jan-Feb; 20(1):35-43. Chen JC, Chang ML, Lee H, Muench MO. PMID: 15608458.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    70. Haploidentical donor T cells fail to facilitate engraftment but lessen the immune response of host T cells in murine fetal transplantation. Br J Haematol. 2004 Aug; 126(3):377-84. Chen JC, Chang ML, Lee H, Muench MO. PMID: 15257710.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    71. Maternal microchimerism in the livers of patients with biliary atresia. BMC Gastroenterol. 2004 Jul 31; 4:14. Suskind DL, Rosenthal P, Heyman MB, Kong D, Magrane G, Baxter-Lowe LA, Muench MO. PMID: 15285784.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    72. Megakaryocyte growth and development factor is a potent growth factor for primitive hematopoietic progenitors in the human fetus. Pediatr Res. 2004 Jun; 55(6):1050-6. Muench MO, Bárcena A. PMID: 15155872.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    73. Stem cell transplantation in the fetus. Cancer Control. 2004 Mar-Apr; 11(2):105-18. Muench MO, Bárcena A. PMID: 15024347.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    74. Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells. J Hepatol. 2004 Feb; 40(2):261-8. Suskind DL, Muench MO. PMID: 14739097.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    75. Ontogenic changes in CD95 expression on human leukocytes: prevalence of T-cells expressing activation markers and identification of CD95-CD45RO+ T-cells in the fetus. Dev Comp Immunol. 2003 Dec; 27(10):899-914. Muench MO, Pott Bärtsch EM, Chen JC, Lopoo JB, Bárcena A. PMID: 12880639.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    76. A kinetic study of the murine mixed lymphocyte reaction by 5,6-carboxyfluorescein diacetate succinimidyl ester labeling. J Immunol Methods. 2003 Aug; 279(1-2):123-33. Chen JC, Chang ML, Muench MO. PMID: 12969553.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    77. Isolation of definitive zone and chromaffin cells based upon expression of CD56 (neural cell adhesion molecule) in the human fetal adrenal gland. J Clin Endocrinol Metab. 2003 Aug; 88(8):3921-30. Muench MO, Ratcliffe JV, Nakanishi M, Ishimoto H, Jaffe RB. PMID: 12915688.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    78. Isolation, growth and identification of colony-forming cells with erythroid, myeloid, dendritic cell and NK-cell potential from human fetal liver. Biol Proced Online. 2002 Jun 11; 4:10-23. Muench MO, Suskind DL, Bárcena A. PMID: 12734573.
      View in: PubMed   Mentions:
    79. Broad distribution of colony-forming cells with erythroid, myeloid, dendritic cell, and NK cell potential among CD34(++) fetal liver cells. J Immunol. 2001 Nov 01; 167(9):4902-9. Muench MO, Bárcena A. PMID: 11673495.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    80. High-efficiency retroviral transduction of fetal liver CD38-CD34++ cells: implications for in utero and ex utero gene therapy. Fetal Diagn Ther. 2001 Sep-Oct; 16(5):299-307. Ohkubo T, Bárcena A, Smith CA, Harrison MR, Muench MO. PMID: 11509853.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    81. Disparate regulation of human fetal erythropoiesis by the microenvironments of the liver and bone marrow. Blood Cells Mol Dis. 2001 Mar-Apr; 27(2):377-90. Muench MO, Namikawa R. PMID: 11259159.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    82. Antibodies to human fetal erythroid cells from a nonimmune phage antibody library. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2682-7. Huie MA, Cheung MC, Muench MO, Becerril B, Kan YW, Marks JD. PMID: 11226299.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    83. Transplantation of a fetus with paternal Thy-1(+)CD34(+)cells for chronic granulomatous disease. Bone Marrow Transplant. 2001 Feb; 27(4):355-64. Muench MO, Rae J, Bárcena A, Leemhuis T, Farrell J, Humeau L, Maxwell-Wiggins JR, Capper J, Mychaliska GB, Albanese CT, Martin T, Tsukamoto A, Curnutte JT, Harrison MR. PMID: 11313664.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    84. Hematopoietic stem cell transplantation in utero produces sheep-goat chimeras. Blood Cells Mol Dis. 2001 Jan-Feb; 27(1):296-308. Oppenheim SM, Muench MO, Gutiérrez-Adán A, Moyer AL, BonDurant RH, Rowe JD, Anderson GB. PMID: 11358392.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    85. Differential effects of interleukin-3, interleukin-7, interleukin 15, and granulocyte-macrophage colony-stimulating factor in the generation of natural killer and B cells from primitive human fetal liver progenitors. Exp Hematol. 2000 Aug; 28(8):961-73. Muench MO, Humeau L, Paek B, Ohkubo T, Lanier LL, Albanese CT, Bárcena A. PMID: 10989197.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    86. Fetal bone marrow as a source of stem cells for in utero or postnatal transplantation. Br J Haematol. 2000 Apr; 109(1):173-81. Golfier F, Bárcena A, Harrison MR, Muench MO. PMID: 10848797.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    87. Role of CD95/Fas and its ligand in the regulation of the growth of human CD34(++)CD38(-) fetal liver cells. Exp Hematol. 1999 Sep; 27(9):1428-39. Bárcena A, Muench MO, Song KS, Ohkubo T, Harrison MR. PMID: 10480434.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    88. Mid-trimester fetal livers are a rich source of CD34+/++ cells for transplantation. Bone Marrow Transplant. 1999 Sep; 24(5):451-61. Golfier F, Bárcena A, Cruz J, Harrison M, Muench M. PMID: 10482927.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    89. Administration of Flk2/Flt3 ligand induces expansion of human high-proliferative potential colony-forming cells in the SCID-hu mouse. Exp Hematol. 1999 Jun; 27(6):1029-37. Namikawa R, Muench MO, Firpo MT, Humeau L, Xu Y, Menon S, Roncarolo MG. PMID: 10378892.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    90. Requirement of retinoids for the expression of CD38 on human hematopoietic progenitors in vitro. Cytotherapy. 1999; 1(6):455-68. Muench MO, Bárcena A, Ohkubo T, Harrison MR. PMID: 20426546.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    91. The biology and ethics of banking fetal liver hematopoietic stem cells for in utero transplantation. J Pediatr Surg. 1998 Feb; 33(2):394-9. Mychaliska GB, Muench MO, Rice HE, Leavitt AD, Cruz J, Harrison MR. PMID: 9498425.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    92. Colony-forming cells expressing high levels of CD34 are the main targets for granulocyte colony-stimulating factor and macrophage colony-stimulating factor in the human fetal liver. Exp Hematol. 1997 Apr; 25(4):277-87. Muench MO, Roncarolo MG, Rosnet O, Birnbaum D, Namikawa R. PMID: 9131001.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    93. Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver. Blood. 1997 Feb 15; 89(4):1364-75. Muench MO, Roncarolo MG, Namikawa R. PMID: 9028960.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    94. Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver. Blood. 1996 Sep 15; 88(6):2013-25. Bárcena A, Park SW, Banapour B, Muench MO, Mechetner E. PMID: 8822920.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    95. Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis. Stem Cells. 1996 Jul; 14(4):388-95. Namikawa R, Muench MO, Roncarolo MG. PMID: 8843540.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    96. The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in vitro. Blood. 1996 Mar 01; 87(5):1881-90. Namikawa R, Muench MO, de Vries JE, Roncarolo MG. PMID: 8634436.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    97. Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus. Leuk Lymphoma. 1995 Mar; 17(1-2):1-11. Bárcena A, Muench MO, Roncarolo MG, Spits H. PMID: 7539656.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    98. FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood. 1995 Feb 15; 85(4):963-72. Muench MO, Roncarolo MG, Menon S, Xu Y, Kastelein R, Zurawski S, Hannum CH, Culpepper J, Lee F, Namikawa R. PMID: 7531516.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    99. Progress in the ex vivo expansion of hematopoietic progenitors. Leuk Lymphoma. 1994 Dec; 16(1-2):1-11. Muench MO, Roncarolo MG, Namikawa R, Bárcena A, Moore MA. PMID: 7696914.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    100. Identification of a common T/natural killer cell progenitor in human fetal thymus. J Exp Med. 1994 Aug 01; 180(2):569-76. Sánchez MJ, Muench MO, Roncarolo MG, Lanier LL, Phillips JH. PMID: 7519241.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    101. Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture. J Exp Med. 1994 Jul 01; 180(1):123-32. Bárcena A, Galy AH, Punnonen J, Muench MO, Schols D, Roncarolo MG, de Vries JE, Spits H. PMID: 7516402.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    102. Expression of CD33, CD38, and HLA-DR on CD34+ human fetal liver progenitors with a high proliferative potential. Blood. 1994 Jun 01; 83(11):3170-81. Muench MO, Cupp J, Polakoff J, Roncarolo MG. PMID: 7514903.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    103. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature. 1994 Apr 14; 368(6472):643-8. Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J. PMID: 8145851.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    104. Interleukin-11 expression in donor bone marrow cells improves hematological reconstitution in lethally irradiated recipient mice. Exp Hematol. 1994 Mar; 22(3):295-301. Paul SR, Hayes LL, Palmer R, Morris GE, Neben TY, Loebelenz J, Pedneault G, Brooks J, Blue I, Moore MA. PMID: 8112427.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    105. In search of T-cell progenitors in the human foetal liver. Res Immunol. 1994 Feb; 145(2):120-3; discussion 155-8. Bárcena A, Muench MO, Roncarolo MG, Spits H. PMID: 7521535.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    106. Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development. Blood. 1993 Dec 01; 82(11):3401-14. Bárcena A, Muench MO, Galy AH, Cupp J, Roncarolo MG, Phillips JH, Spits H. PMID: 7694684.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    107. Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential. Blood. 1993 Jun 15; 81(12):3463-73. Muench MO, Firpo MT, Moore MA. PMID: 7685206.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    108. Development of a lacZ marked WEHI-3B D+ murine leukemic cell line as an in-vivo model of acute non-lymphocytic leukemia. Leukemia. 1993 Feb; 7(2):310-7. Smith C, Muench MO, Knizewski M, Gilboa E, Moore MA. PMID: 8426483.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    109. Ex vivo differentiation therapy as a method of leukemic cell purging in murine bone marrow expansion cultures. Cancer Res. 1992 Dec 01; 52(23):6576-82. Muench MO, Guy Z, Moore MA. PMID: 1384966.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    110. The in vitro growth of murine high proliferative potential-colony forming cells is not enhanced by growth in a low oxygen atmosphere. Cytokine. 1992 Nov; 4(6):488-94. Muench MO, Gasparetto C, Moore MA. PMID: 1292631.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    111. Accelerated recovery of peripheral blood cell counts in mice transplanted with in vitro cytokine-expanded hematopoietic progenitors. Exp Hematol. 1992 Jun; 20(5):611-8. Muench MO, Moore MA. PMID: 1587307.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    112. Interactions among colony-stimulating factors, IL-1 beta, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells. Exp Hematol. 1992 Mar; 20(3):339-49. Muench MO, Schneider JG, Moore MA. PMID: 1373685.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    113. Purification and partial characterization of a human hematopoietic precursor population. Blood. 1991 May 15; 77(10):2122-8. Smith C, Gasparetto C, Collins N, Gillio A, Muench MO, O'Reilly RJ, Moore MA. PMID: 1709369.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    114. Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation. Ciba Found Symp. 1990; 148:43-58; discussion 58-61. Moore MA, Muench MO, Warren DJ, Laver J. PMID: 2180648.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    115. Radioprotection by murine and human tumor-necrosis factor: dose-dependent effects on hematopoiesis in the mouse. Eur J Haematol. 1989 Nov; 43(5):428-34. Slørdal L, Muench MO, Warren DJ, Moore MA. PMID: 2612616.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
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