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Ritchie Chen, PhD, MSc

Title(s)Assistant Professor, Neurological Surgery
SchoolSchool of Medicine
Address1651 4th Street, #511B
San Francisco CA 94158
PronounsHe/Him/His
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    Other Positions
    Title(s)Kinetics Foundation Chair in Translational Research


    Collapse Biography 
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    University of California, BerkeleyB.S.2010Bioengineering, Materials Science and Engineering
    Massachusetts Institute of TechnologyPh.D.2016Materials Science and Engineering

    Collapse Overview 
    Collapse overview
    We engineer technologies to study brain-body physiology and to inform new therapeutic approaches for bioelectronic medicine. We fuse approaches in synthetic biology, nanotechnology, device engineering, and systems neuroscience to develop genetically-targeted tools to target, map, readout, and/or control neural circuits while minimizing damage to tissue.
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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling. Cell. 2025 Aug 21; 188(17):4640-4657.e30. Drexler R, Drinnenberg A, Gavish A, Yalçin B, Shamardani K, Rogers AE, Mancusi R, Trivedi V, Taylor KR, Kim YS, Woo PJ, Soni N, Su M, Ravel A, Tatlock E, Midler A, Wu SH, Ramakrishnan C, Chen R, Ayala-Sarmiento AE, Fernandez Pacheco DR, Siverts L, Daigle TL, Tasic B, Zeng H, Breunig JJ, Deisseroth K, Monje M. PMID: 40541184; PMCID: PMC12396346.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    2. Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2411724122. Crowther AJ, Kashem SW, Jewell ME, Le Chang H, Midavaine É, Rosa Casillas M, Danchine V, Rodriguez S, Kania A, Chen R, Braz JM, Basbaum AI. PMID: 40498457; PMCID: PMC12184494.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Interoceptive modulation of emotions. Curr Opin Neurobiol. 2025 Jun; 92:103049. Zsembik L, Oldroyd P, Chen R. . PMID: 40378580.
      View in: PubMed   Mentions:
    4. Integrated Bioelectronic and Optogenetic Methods to Study Brain-Body Circuits. ACS Nano. 2024 Nov 05; 18(44):30117-30122. Zhang QR, Wang SX, Chen R. . PMID: 39443299; PMCID: PMC11544702.
      View in: PubMed   Mentions:
    5. Lifelong restructuring of 3D genome architecture in cerebellar granule cells. Science. 2023 Sep 08; 381(6662):1112-1119. Tan L, Shi J, Moghadami S, Parasar B, Wright CP, Seo Y, Vallejo K, Cobos I, Duncan L, Chen R, Deisseroth K. PMID: 37676945; PMCID: PMC11059189.
      View in: PubMed   Mentions:
    6. Cardiogenic control of affective behavioural state. Nature. 2023 03; 615(7951):292-299. Hsueh B, Chen R, Jo Y, Tang D, Raffiee M, Kim YS, Inoue M, Randles S, Ramakrishnan C, Patel S, Kim DK, Liu TX, Kim SH, Tan L, Mortazavi L, Cordero A, Shi J, Zhao M, Ho TT, Crow A, Yoo AW, Raja C, Evans K, Bernstein D, Zeineh M, Goubran M, Deisseroth K. PMID: 36859543; PMCID: PMC9995271.
      View in: PubMed   Mentions: 111     Fields:    Translation:Animals
    7. Cerebellar Granule Cells Develop Non-neuronal 3D Genome Architecture over the Lifespan. bioRxiv. 2023 Feb 27. Tan L, Shi J, Moghadami S, Wright CP, Parasar B, Seo Y, Vallejo K, Cobos I, Duncan L, Chen R, Deisseroth K. PMID: 36865235; PMCID: PMC9980173.
      View in: PubMed   Mentions:
    8. Cell-type-specific population dynamics of diverse reward computations. Cell. 2022 09 15; 185(19):3568-3587.e27. Sylwestrak EL, Jo Y, Vesuna S, Wang X, Holcomb B, Tien RH, Kim DK, Fenno L, Ramakrishnan C, Allen WE, Chen R, Shenoy KV, Sussillo D, Deisseroth K. PMID: 36113428; PMCID: PMC10387374.
      View in: PubMed   Mentions: 28     Fields:    
    9. Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development. Cell. 2021 02 04; 184(3):741-758.e17. Tan L, Ma W, Wu H, Zheng Y, Xing D, Chen R, Li X, Daley N, Deisseroth K, Xie XS. PMID: 33484631.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    10. Deep brain optogenetics without intracranial surgery. Nat Biotechnol. 2021 02; 39(2):161-164. Chen R, Gore F, Nguyen QA, Ramakrishnan C, Patel S, Kim SH, Raffiee M, Kim YS, Hsueh B, Krook-Magnusson E, Soltesz I, Deisseroth K. PMID: 33020604; PMCID: PMC7878426.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    11. Multiple convergent hypothalamus-brainstem circuits drive defensive behavior. Nat Neurosci. 2020 08; 23(8):959-967. Lovett-Barron M, Chen R, Bradbury S, Andalman AS, Wagle M, Guo S, Deisseroth K. PMID: 32572237; PMCID: PMC7687349.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    12. Stretchable and Fully Degradable Semiconductors for Transient Electronics. ACS Cent Sci. 2019 Nov 27; 5(11):1884-1891. Tran H, Feig VR, Liu K, Wu HC, Chen R, Xu J, Deisseroth K, Bao Z. PMID: 31807690; PMCID: PMC6891860.
      View in: PubMed   Mentions: 24  
    13. Remotely controlled chemomagnetic modulation of targeted neural circuits. Nat Nanotechnol. 2019 10; 14(10):967-973. Rao S, Chen R, LaRocca AA, Christiansen MG, Senko AW, Shi CH, Chiang PH, Varnavides G, Xue J, Zhou Y, Park S, Ding R, Moon J, Feng G, Anikeeva P. PMID: 31427746; PMCID: PMC6778020.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    14. Neuronal Dynamics Regulating Brain and Behavioral State Transitions. Cell. 2019 05 02; 177(4):970-985.e20. Andalman AS, Burns VM, Lovett-Barron M, Broxton M, Poole B, Yang SJ, Grosenick L, Lerner TN, Chen R, Benster T, Mourrain P, Levoy M, Rajan K, Deisseroth K. PMID: 31031000; PMCID: PMC6726130.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    15. Protection of tissue physicochemical properties using polyfunctional crosslinkers. Nat Biotechnol. 2018 Dec 17. Park YG, Sohn CH, Chen R, McCue M, Yun DH, Drummond GT, Ku T, Evans NB, Oak HC, Trieu W, Choi H, Jin X, Lilascharoen V, Wang J, Truttmann MC, Qi HW, Ploegh HL, Golub TR, Chen SC, Frosch MP, Kulik HJ, Lim BK, Chung K. PMID: 30556815; PMCID: PMC6579717.
      View in: PubMed   Mentions: 190     Fields:    
    16. One-step optogenetics with multifunctional flexible polymer fibers. Nat Neurosci. 2017 Apr; 20(4):612-619. Park S, Guo Y, Jia X, Choe HK, Grena B, Kang J, Park J, Lu C, Canales A, Chen R, Yim YS, Choi GB, Fink Y, Anikeeva P. PMID: 28218915; PMCID: PMC5374019.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    17. Neural Recording and Modulation Technologies. Nat Rev Mater. 2017 Feb; 2(2). Chen R, Canales A, Anikeeva P. PMID: 31448131; PMCID: PMC6707077.
      View in: PubMed   Mentions: 198  
    18. High-Performance Ferrite Nanoparticles through Nonaqueous Redox Phase Tuning. Nano Lett. 2016 Feb 10; 16(2):1345-51. Chen R, Christiansen MG, Sourakov A, Mohr A, Matsumoto Y, Okada S, Jasanoff A, Anikeeva P. PMID: 26756463.
      View in: PubMed   Mentions: 30     Fields:    
    19. Engineering intracellular biomineralization and biosensing by a magnetic protein. Nat Commun. 2015 Nov 02; 6:8721. Matsumoto Y, Chen R, Anikeeva P, Jasanoff A. PMID: 26522873; PMCID: PMC4667635.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    20. Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates. Adv Healthc Mater. 2015 Oct; 4(14):2100-2109. Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P. PMID: 26288378.
      View in: PubMed   Mentions: 11     Fields:    
    21. Wireless magnetothermal deep brain stimulation. Science. 2015 Mar 27; 347(6229):1477-80. Chen R, Romero G, Christiansen MG, Mohr A, Anikeeva P. PMID: 25765068.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    22. Maximizing hysteretic losses in magnetic ferrite nanoparticles via model-driven synthesis and materials optimization. ACS Nano. 2013 Oct 22; 7(10):8990-9000. Chen R, Christiansen MG, Anikeeva P. PMID: 24016039.
      View in: PubMed   Mentions: 38     Fields:    
    23. Folding of a single-chain, information-rich polypeptoid sequence into a highly ordered nanosheet. Biopolymers. 2011; 96(5):586-95. Kudirka R, Tran H, Sanii B, Nam KT, Choi PH, Venkateswaran N, Chen R, Whitelam S, Zuckermann RN. PMID: 22180906.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    24. Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers. Nat Mater. 2010 May; 9(5):454-60. Nam KT, Shelby SA, Choi PH, Marciel AB, Chen R, Tan L, Chu TK, Mesch RA, Lee BC, Connolly MD, Kisielowski C, Zuckermann RN. PMID: 20383129.
      View in: PubMed   Mentions: 74     Fields:    Translation:Cells
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