Allan Basbaum, PhD

Title(s)Professor, Anatomy
SchoolSchool of Medicine
Address1550 Fourth St
San Francisco CA 94158
Phone415-476-4311
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    Other Positions
    Title(s)Chair, Anatomy


    Collapse Biography 
    Collapse Education and Training
    McGill University, Montreal, Quebec, CanadaBScNeuroscience
    University Pennsylvania, Philadelphia, pAPhD172Neuroscien
    University College London, London, UKPostdoc1975Neuroscience
    University California San Francisco, San Francisco, CAPostdoc1977

    Collapse Overview 
    Collapse Overview
    Our laboratory examines the mechanisms through which tissue and nerve injury produce changes in the peripheral and central nervous system, resulting in persistent pain. In parallel studies we are examining the circuits through which pruritogens generate itch. These studies follow upon our recent work that defined mechanisms through which opioids that act at different receptor subtypes exert their pain relieving effects. The hallmark of our work is our laboratory’s multidisciplinary approach to the problem, using molecular, neuroanatomical, pharmacological and behavioral analyses in wild type and genetically modified mice. Many of these mice, including knockouts and Cre- or reporter-expressing mice are generated in our laboratory. To expand our analyses using our transgenic mouse in which wheat germ agglutinin transneuronal labeling of complex circuits can be triggered from neurons in any region of the brain or spinal cord, we now incorporate transneuronal anterograde (herpes) and retrograde (rabies) viral tracers in our circuit analyses. By combining these studies with the functional properties of the label neurons, these studies will examine the extent to which pain and itch circuits are segregated or convergent at the level of spinal cord interneurons and projection neurons. Most recently, we turned our attention to the possibility of overcoming the neurological consequences of peripheral nerve damage, by transplanting embryonic cortical GABAergic precursor cells into the spinal cord. We have demonstrated that the cells integrate into the host and can ameliorate the persistent pain and itch associated with nerve damage.

    Collapse Research 
    Collapse Research Activities and Funding
    From the spinal cord to the brain: Neurology of the pain and itch neurons
    NIH R35NS097306Dec 1, 2016 - Nov 30, 2024
    Role: Principal Investigator
    Influence of drug abuse on neuronal nuclear and chromatin architecture
    NIH R01DA036985Jul 1, 2013 - Sep 30, 2017
    Role: Principal Investigator
    Spinal Cord Transplants of GABAergic Precursor Cells to Treat Chronic Pain
    NIH R01NS078326Sep 28, 2012 - Jun 30, 2017
    Role: Co-Principal Investigator
    Epigenetic and genetic contributors to chronic neuropathic pain
    NIH R01DE022001Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator
    Multiple Opioid Receptors and the Control of Pain
    NIH R01DA029204Jul 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Receptors and Second Messengers for Pain and Analgesia
    NIH P01NS053709Sep 1, 2007 - Jun 30, 2013
    Role: Co-Investigator
    SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    NIH R01DA008377Aug 1, 1993 - Jun 30, 2003
    Role: Principal Investigator
    Trigeminal Pain, Mechanisms and Control
    NIH P01DE008973Sep 1, 1990 - Aug 31, 2007
    Role: Co-Investigator
    MECHANISMS OF PAIN AND ANALGESIA
    NIH P50NS021445Jan 1, 1985 - Dec 31, 2005
    Role: Co-Investigator
    MECHANISMS OF PAIN AND ANALGESIA
    NIH P01NS021445Jan 1, 1985 - Dec 31, 1999
    Role: Co-Investigator
    Function and development in the synapse
    NIH P01NS016033Apr 1, 1980 - Jun 30, 2009
    Role: Co-Investigator
    Brainstem control of pain transmission
    NIH R37NS014627Jul 15, 1978 - Jun 30, 2015
    Role: Principal Investigator
    Brainstem control of pain transmission
    NIH R01NS014627Jul 1, 1978 - Mar 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proc Natl Acad Sci U S A. 2021 Jul 13; 118(28). Wercberger R, Braz JM, Weinrich JA, Basbaum AI. PMID: 34234018.
      View in: PubMed   Mentions:    Fields:    
    2. Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity. Elife. 2021 Jun 01; 10. Löken LS, Braz JM, Etlin A, Sadeghi M, Bernstein M, Jewell M, Steyert M, Kuhn J, Hamel K, Llewellyn-Smith IJ, Basbaum A. PMID: 34061020.
      View in: PubMed   Mentions:    Fields:    
    3. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures. Proc Natl Acad Sci U S A. 2021 May 18; 118(20). Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY. PMID: 33972431.
      View in: PubMed   Mentions:    Fields:    
    4. Contribution of colony-stimulating factor 1 to neuropathic pain. Pain Rep. 2021; 6(1):e883. Yu X, Basbaum A, Guan Z. PMID: 33981926.
      View in: PubMed   Mentions:
    5. Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Braz JM, Dembo T, Charruyer A, Ghadially R, Fassett MS, Basbaum AI. PMID: 33602818.
      View in: PubMed   Mentions: 1     Fields:    
    6. Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021 01 04; 4(1):e2032236. Xu A, Larsen B, Henn A, Baller EB, Scott JC, Sharma V, Adebimpe A, Basbaum AI, Corder G, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, Satterthwaite TD. PMID: 33399857.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing. PLoS One. 2020; 15(2):e0226289. Alvaro CG, Braz JM, Bernstein M, Hamel KA, Craik V, Yamanaka H, Basbaum AI. PMID: 32015563.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Convergent neural representations of experimentally-induced acute pain in healthy volunteers: A large-scale fMRI meta-analysis. Neurosci Biobehav Rev. 2020 05; 112:300-323. Xu A, Larsen B, Baller EB, Scott JC, Sharma V, Adebimpe A, Basbaum AI, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, Satterthwaite TD. PMID: 31954149.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    9. Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nat Commun. 2020 01 14; 11(1):264. Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI. PMID: 31937758.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    10. Ablation of spinal cord estrogen receptor a-expressing interneurons reduces chemically induced modalities of pain and itch. J Comp Neurol. 2020 07; 528(10):1629-1643. Tran M, Braz JM, Hamel K, Kuhn J, Todd AJ, Basbaum AI. PMID: 31872868.
      View in: PubMed   Mentions: 2     Fields:    
    11. Spinal cord projection neurons: a superficial, and also deep, analysis. Curr Opin Physiol. 2019 Oct; 11:109-115. Wercberger R, Basbaum AI. PMID: 32864531.
      View in: PubMed   Mentions:
    12. GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness. Brain. 2019 09 01; 142(9):2655-2669. Juarez-Salinas DL, Braz JM, Etlin A, Gee S, Sohal V, Basbaum AI. PMID: 31321411.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Mispositioned Neurokinin-1 Receptor-Expressing Neurons Underlie Heat Hyperalgesia in Disabled-1 Mutant Mice. eNeuro. 2019 May/Jun; 6(3). Wang X, Yvone GM, Cilluffo M, Kim AS, Basbaum AI, Phelps PE. PMID: 31122949.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion. Neuron. 2019 06 05; 102(5):944-959.e3. Meda KS, Patel T, Braz JM, Malik R, Turner ML, Seifikar H, Basbaum AI, Sohal VS. PMID: 31030955.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    15. Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn. Pain. 2019 Feb; 160(2):442-462. Dickie AC, Bell AM, Iwagaki N, Polgár E, Gutierrez-Mecinas M, Kelly R, Lyon H, Turnbull K, West SJ, Etlin A, Braz J, Watanabe M, Bennett DLH, Basbaum AI, Riddell JS, Todd AJ. PMID: 30247267.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Primary Afferent-Derived BDNF Contributes Minimally to the Processing of Pain and Itch. eNeuro. 2018 Nov-Dec; 5(6). Dembo T, Braz JM, Hamel KA, Kuhn JA, Basbaum AI. PMID: 30627644.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls. Pain Rep. 2018 Jul-Aug; 3(4):e659. Juarez-Salinas DL, Braz JM, Hamel KA, Basbaum AI. PMID: 30123855.
      View in: PubMed   Mentions:
    18. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 07; 19(7):383-384. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. PMID: 29765159.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. NaV1.1 inhibition can reduce visceral hypersensitivity. JCI Insight. 2018 06 07; 3(11). Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F. PMID: 29875317.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron. 2018 04 04; 98(1):90-108.e5. Wang D, Tawfik VL, Corder G, Low SA, François A, Basbaum AI, Scherrer G. PMID: 29576387.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    21. Long-term, dynamic synaptic reorganization after GABAergic precursor cell transplantation into adult mouse spinal cord. J Comp Neurol. 2018 Feb 15; 526(3):480-495. Llewellyn-Smith IJ, Basbaum AI, Bráz JM. PMID: 29134656.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Chemogenetic management of neuropathic pain. Brain. 2017 10 01; 140(10):2522-2525. Basbaum A. PMID: 28969393.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Neuronal aromatase expression in pain processing regions of the medullary and spinal cord dorsal horn. J Comp Neurol. 2017 Nov 01; 525(16):3414-3428. Tran M, Kuhn JA, Bráz JM, Basbaum AI. PMID: 28649695.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):E2524-E2532. Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D. PMID: 28265084.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2017 Aug; 140(2):454-464.e2. Cevikbas F, Braz JM, Wang X, Solorzano C, Sulk M, Buhl T, Steinhoff M, Basbaum AI. PMID: 28232084.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    26. Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch. Prog Brain Res. 2017; 231:87-105. Braz JM, Etlin A, Juarez-Salinas D, Llewellyn-Smith IJ, Basbaum AI. PMID: 28554402.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord. J Neurosci. 2016 11 16; 36(46):11634-11645. Etlin A, Bráz JM, Kuhn JA, Wang X, Hamel KA, Llewellyn-Smith IJ, Basbaum AI. PMID: 27852772.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    28. Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE. Exp Neurol. 2016 09; 283(Pt A):224-34. Frezel N, Sohet F, Daneman R, Basbaum AI, Braz JM. PMID: 27343802.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    29. Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 06 23; 534(7608):494-9. Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D. PMID: 27281198.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    30. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain. 2016 Apr; 157(4):901-909. Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice ASC, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G. PMID: 26683237.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    31. Cell transplants to treat the "disease" of neuropathic pain and itch. Pain. 2016 Feb; 157 Suppl 1:S42-S47. Basbaum AI, Bráz JM. PMID: 26780378.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    32. Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016 Jan; 19(1):94-101. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI. PMID: 26642091.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    33. Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli. PLoS One. 2015; 10(12):e0142906. Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH. PMID: 26630489.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury. Cell Rep. 2015 Nov 10; 13(6):1246-1257. Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R. PMID: 26527000.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    35. Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection. PLoS One. 2015; 10(10):e0140681. Bráz JM, Wang F, Basbaum AI. PMID: 26470056.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine. Sci Transl Med. 2015 Sep 16; 7(305):305ra145. Brown JD, Saeed M, Do L, Braz J, Basbaum AI, Iadarola MJ, Wilson DM, Dillon WP. PMID: 26378245.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. In Memoriam Jean-Marie Besson 1938-2014. Eur J Pain. 2015 Aug; 19(7):871-6. Villanueva L, Bouhassira D, Dickenson T, Basbaum A, Zimmermann M. PMID: 26173566.
      View in: PubMed   Mentions:    Fields:    
    38. Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Pain. 2015 Jun; 156(6):1084-1091. Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI. PMID: 25760475.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    39. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci. 2015 Jan 14; 35(2):648-57. Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI. PMID: 25589759.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    40. Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch. J Clin Invest. 2014 Aug; 124(8):3612-6. Braz JM, Juarez-Salinas D, Ross SE, Basbaum AI. PMID: 25003193.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    41. Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control. Neuron. 2014 May 07; 82(3):522-36. Braz J, Solorzano C, Wang X, Basbaum AI. PMID: 24811377.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    42. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622. Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A. PMID: 24723614.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    43. Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn. Neuron. 2014 Mar 19; 81(6):1443. Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G. PMID: 28898633.
      View in: PubMed   Mentions: 9     Fields:    
    44. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron. 2014 Mar 19; 81(6):1312-1327. Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G. PMID: 24583022.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    45. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol. 2014 Feb; 133(2):448-60. Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M. PMID: 24373353.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    46. Identification of multisegmental nociceptive afferents that modulate locomotor circuits in the neonatal mouse spinal cord. J Comp Neurol. 2013 Aug 15; 521(12):2870-87. Mandadi S, Hong P, Tran MA, Bráz JM, Colarusso P, Basbaum AI, Whelan PJ. PMID: 23436436.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    47. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013 Sep; 16(9):1284-90. Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY. PMID: 23872594.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    48. Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch. Neuron. 2013 Apr 24; 78(2):312-24. Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, Yamanaka H, Rice D, Basbaum AI. PMID: 23622066.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    49. Paradoxical surrogate markers of dental injury-induced pain in the mouse. Pain. 2013 Aug; 154(8):1358-67. Gibbs JL, Urban R, Basbaum AI. PMID: 23719574.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    50. The modality-specific contribution of peptidergic and non-peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons. J Physiol. 2013 Feb 15; 591(4):1097-110. Zhang J, Cavanaugh DJ, Nemenov MI, Basbaum AI. PMID: 23266932.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    51. Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain. Neuron. 2012 May 24; 74(4):663-75. Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI. PMID: 22632725.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    52. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16; 479(7373):410-4. Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D. PMID: 22094702.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    53. Sciatic nerve transection triggers release and intercellular transfer of a genetically expressed macromolecular tracer in dorsal root ganglia. J Comp Neurol. 2011 Sep 01; 519(13):2648-57. Bráz JM, Ackerman L, Basbaum AI. PMID: 21484801.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    54. Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci. 2011 Jul 13; 31(28):10119-27. Cavanaugh DJ, Chesler AT, Bráz JM, Shah NM, Julius D, Basbaum AI. PMID: 21752988.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    55. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci. 2011 Mar 30; 31(13):5067-77. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI. PMID: 21451044.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimalsCells
    56. Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity. Pain. 2011 May; 152(5):990-1000. Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI. PMID: 21256675.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    57. Targeting pain where it resides ... In the brain. Sci Transl Med. 2011 Jan 12; 3(65):65ps1. Sharif-Naeini R, Basbaum AI. PMID: 21228395.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    58. Introducing the Biennial review of pain. Pain. 2011 Mar; 152(3 Suppl):S1. Mogil JS, Basbaum AI. PMID: 21144660.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    59. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22296-301. Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI. PMID: 21135246.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    60. Olfactory ensheathing glia express aquaporin 1. J Comp Neurol. 2010 Nov 01; 518(21):4329-41. Shields SD, Moore KD, Phelps PE, Basbaum AI. PMID: 20853510.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    61. Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors. Pain. 2010 Nov; 151(2):422-429. Shields SD, Cavanaugh DJ, Lee H, Anderson DJ, Basbaum AI. PMID: 20832171.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    62. Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli. Pain. 2010 Aug; 150(2):290-301. Bráz JM, Basbaum AI. PMID: 20605331.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    63. Effect of topical 0.5% morphine on postoperative pain after photorefractive keratectomy. J Refract Surg. 2010 Dec; 26(12):934-41. Faktorovich EG, Basbaum AI. PMID: 20166624.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    64. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature. 2009 Dec 03; 462(7273):651-5. Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH. PMID: 19915548.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    65. Cellular and molecular mechanisms of pain. Cell. 2009 Oct 16; 139(2):267-84. Basbaum AI, Bautista DM, Scherrer G, Julius D. PMID: 19837031.
      View in: PubMed   Mentions: 1028     Fields:    Translation:HumansAnimalsCells
    66. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11330-5. Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK. PMID: 19564617.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    67. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell. 2009 Jun 12; 137(6):1148-59. Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O'Donnell D, Kieffer BL, Basbaum AI. PMID: 19524516.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    68. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):9075-80. Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ. PMID: 19451647.
      View in: PubMed   Mentions: 249     Fields:    Translation:AnimalsCells
    69. Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing. J Comp Neurol. 2009 May 10; 514(2):145-60. Braz JM, Enquist LW, Basbaum AI. PMID: 19274668.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    70. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J Neurosci. 2009 Apr 29; 29(17):5508-15. Wang X, Ratnam J, Zou B, England PM, Basbaum AI. PMID: 19403818.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    71. Change is coming! Pain. 2009 Jan; 141(1-2):1. Basbaum AI. PMID: 19100687.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    72. Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth. J Neurosci Methods. 2009 Mar 15; 177(2):322-33. Ossovskaya VS, Dolganov G, Basbaum AI. PMID: 19026687.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    73. Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31; 139(3):533-540. Nikai T, Basbaum AI, Ahn AH. PMID: 18723285.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    74. Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. J Neurosci. 2008 Aug 06; 28(32):7936-44. Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI. PMID: 18685019.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    75. Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits. J Comp Neurol. 2008 Apr 20; 507(6):1990-2003. Braz JM, Basbaum AI. PMID: 18273889.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    76. Contribution of the Reelin signaling pathways to nociceptive processing. Eur J Neurosci. 2008 Feb; 27(3):523-37. Akopians AL, Babayan AH, Beffert U, Herz J, Basbaum AI, Phelps PE. PMID: 18279306.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    77. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13519-24. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. PMID: 17684094.
      View in: PubMed   Mentions: 286     Fields:    Translation:HumansCells
    78. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007 Jul 12; 448(7150):204-8. Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. PMID: 17538622.
      View in: PubMed   Mentions: 413     Fields:    Translation:Animals
    79. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain. 2007 Sep; 131(1-2):8-20. Shields SD, Mazario J, Skinner K, Basbaum AI. PMID: 17257750.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    80. Contribution of substance P and neurokinin A to the differential injury-induced thermal and mechanical responsiveness of lamina I and V neurons. J Neurosci. 2007 Jan 24; 27(4):762-70. Mazarío J, Basbaum AI. PMID: 17251415.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    81. Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature. 2006 Nov 09; 444(7116):208-12. Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D. PMID: 17093448.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    82. Reviews: topical, systematic and once again, comprehensive. Pain. 2006 Oct; 124(3):237. Basbaum AI. PMID: 16934404.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    83. Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain. J Neurosci. 2006 Aug 09; 26(32):8332-8. Ahn AH, Basbaum AI. PMID: 16899728.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    84. Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9691-6. Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, Kieffer BL. PMID: 16766653.
      View in: PubMed   Mentions: 111     Fields:    Translation:Animals
    85. Toward better pain control. Sci Am. 2006 Jun; 294(6):60-7. Basbaum AI, Julius D. PMID: 16711361.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    86. Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. J Proteome Res. 2006 Apr; 5(4):1017-23. Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, Wang HY, Jackson SN, Zeitz P, Zeitz KP, Zolkowska D, Schepers R, Nold M, Danielson J, Gräslund A, Vukojevic V, Bakalkin G, Basbaum A, Shippenberg T. PMID: 16602711.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    87. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006 Mar 24; 124(6):1269-82. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. PMID: 16564016.
      View in: PubMed   Mentions: 693     Fields:    Translation:AnimalsCellsPHPublic Health
    88. Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16848-52. Neumann S, Skinner K, Basbaum AI. PMID: 16275900.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    89. Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron. 2005 Sep 15; 47(6):787-93. Braz JM, Nassar MA, Wood JN, Basbaum AI. PMID: 16157274.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    90. A neuropeptide courier for delta-opioid receptors? Cell. 2005 Aug 26; 122(4):496-8. Julius D, Basbaum AI. PMID: 16122418.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    91. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem. 2005 Sep 09; 280(36):31405-12. Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM. PMID: 15987694.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    92. Where do triptans act in the treatment of migraine? Pain. 2005 May; 115(1-2):1-4. Ahn AH, Basbaum AI. PMID: 15836963.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    93. A new way to lose your nerve. Sci Aging Knowledge Environ. 2004 Apr 14; 2004(15):pe15. Basbaum AI. PMID: 15084736.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    94. Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat. Eur J Neurosci. 2004 Apr; 19(7):1789-99. Sanderson Nydahl K, Skinner K, Julius D, Basbaum AI. PMID: 15078552.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    95. Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. J Comp Neurol. 2004 Mar 15; 470(4):400-8. Lewinter RD, Skinner K, Julius D, Basbaum AI. PMID: 14961565.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    96. Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo. J Neurophysiol. 2004 May; 91(5):1945-54. Martin WJ, Cao Y, Basbaum AI. PMID: 14711972.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    97. Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans. J Neurosci. 2003 Nov 26; 23(34):10988-97. Potrebic S, Ahn AH, Skinner K, Fields HL, Basbaum AI. PMID: 14645495.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    98. Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis. J Pain. 2003 Oct; 4(8):465-70. Shields SD, Eckert WA, Basbaum AI. PMID: 14622667.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    99. Systemic morphine-induced release of serotonin in the rostroventral medulla is not mimicked by morphine microinjection into the periaqueductal gray. J Neurochem. 2003 Sep; 86(5):1129-41. Taylor BK, Basbaum AI. PMID: 12911621.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    100. Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2003 May; 284(5):G830-6. Bhatia M, Slavin J, Cao Y, Basbaum AI, Neoptolemos JP. PMID: 12684214.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    101. Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T. Pain. 2003 Jan; 101(1-2):109-16. Malmberg AB, Gilbert H, McCabe RT, Basbaum AI. PMID: 12507705.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    102. Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):271-6. Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, Basbaum AI. PMID: 12496346.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    103. Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15148-53. Braz JM, Rico B, Basbaum AI. PMID: 12391304.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    104. Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network. J Neurophysiol. 2002 Jul; 88(1):206-13. Telgkamp P, Cao YQ, Basbaum AI, Ramirez JM. PMID: 12091546.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    105. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron. 2002 Jun 13; 34(6):885-93. Neumann S, Bradke F, Tessier-Lavigne M, Basbaum AI. PMID: 12086637.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    106. Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions. Brain Res. 2002 Mar 15; 930(1-2):150-62. Abbadie C, Lombard MC, Besson JM, Trafton JA, Basbaum AI. PMID: 11879805.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    107. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci. 2002 Feb 01; 22(3):1010-9. Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI. PMID: 11826129.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    108. Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice. Pain. 2001 Dec; 94(3):245-253. Zeitz KP, Malmberg AB, Gilbert H, Basbaum AI. PMID: 11731061.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    109. Second messengers, the substantia gelatinosa and injury-induced persistent pain. Pain. 1999 Aug; Suppl 6:S5-S12. Petersen-Zeitz KR, Basbaum AI. PMID: 10491967.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    110. Spinal cannabinoids are anti-allodynic in rats with persistent inflammation. Pain. 1999 Aug; 82(2):199-205. Martin WJ, Loo CM, Basbaum AI. PMID: 10467924.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    111. The development of opioid tolerance in the formalin test in the rat. Pain. 1995 Nov; 63(2):251-254. Detweiler DJ, Rohde DS, Basbaum AI. PMID: 8628591.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    112. Insights into the development of opioid tolerance. Pain. 1995 Jun; 61(3):349-352. Basbaum AI. PMID: 7478677.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    113. Do opioids evoke the release of serotonin in the spinal cord? An in vivo microdialysis study of the regulation of extracellular serotonin in the rat. Pain. 1992 Mar; 48(3):439-447. Matos FF, Rollema H, Brown JL, Basbaum AI. PMID: 1375724.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    114. Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions. Pain. 1977 Feb; 3(1):43-56. Basbaum AI, Marley NJE, O'Keefe J, Clanton CH. PMID: 876666.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
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