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Allan Basbaum, PhD

Title(s)Professor, Anatomy
SchoolSchool of Medicine
Phone415-476-5270
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    Other Positions
    Title(s)Chair, Anatomy


    Collapse Biography 
    Collapse Education and Training
    McGill University, Montreal, Quebec, CanadaBScNeuroscience
    University Pennsylvania, Philadelphia, pAPhD172Neuroscien
    University College London, London, UKPostdoc1975Neuroscience
    University California San Francisco, San Francisco, CAPostdoc1977

    Collapse Overview 
    Collapse Overview
    Our laboratory examines the mechanisms through which tissue and nerve injury produce changes in the peripheral and central nervous system, resulting in persistent pain. In parallel studies we are examining the circuits through which pruritogens generate itch. These studies follow upon our recent work that defined mechanisms through which opioids that act at different receptor subtypes exert their pain relieving effects. The hallmark of our work is our laboratory’s multidisciplinary approach to the problem, using molecular, neuroanatomical, pharmacological and behavioral analyses in wild type and genetically modified mice. Many of these mice, including knockouts and Cre- or reporter-expressing mice are generated in our laboratory. To expand our analyses using our transgenic mouse in which wheat germ agglutinin transneuronal labeling of complex circuits can be triggered from neurons in any region of the brain or spinal cord, we now incorporate transneuronal anterograde (herpes) and retrograde (rabies) viral tracers in our circuit analyses. By combining these studies with the functional properties of the label neurons, these studies will examine the extent to which pain and itch circuits are segregated or convergent at the level of spinal cord interneurons and projection neurons. Most recently, we turned our attention to the possibility of overcoming the neurological consequences of peripheral nerve damage, by transplanting embryonic cortical GABAergic precursor cells into the spinal cord. We have demonstrated that the cells integrate into the host and can ameliorate the persistent pain and itch associated with nerve damage.

    Collapse Research 
    Collapse Research Activities and Funding
    From the spinal cord to the brain: Neurology of the pain and itch neurons
    NIH/NINDS R35NS097306Dec 1, 2016 - Nov 30, 2024
    Role: Principal Investigator
    Influence of drug abuse on neuronal nuclear and chromatin architecture
    NIH/NIDA R01DA036985Jul 1, 2013 - Mar 31, 2017
    Role: Principal Investigator
    Spinal Cord Transplants of GABAergic Precursor Cells to Treat Chronic Pain
    NIH/NINDS R01NS078326Sep 28, 2012 - Jun 30, 2017
    Role: Co-Principal Investigator
    Epigenetic and genetic contributors to chronic neuropathic pain
    NIH/NIDCR R01DE022001Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator
    Multiple Opioid Receptors and the Control of Pain
    NIH/NIDA R01DA029204Jul 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Receptors and Second Messengers for Pain and Analgesia
    NIH/NINDS P01NS053709Sep 1, 2007 - Jun 30, 2013
    Role: Co-Investigator
    SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE
    NIH/NIDA R01DA008377Aug 1, 1993 - Jun 30, 2003
    Role: Principal Investigator
    Trigeminal Pain, Mechanisms and Control
    NIH/NIDCR P01DE008973Sep 1, 1990 - Aug 31, 2007
    Role: Co-Investigator
    MECHANISMS OF PAIN AND ANALGESIA
    NIH/NINDS P50NS021445Jan 1, 1985 - Dec 31, 2005
    Role: Co-Investigator
    MECHANISMS OF PAIN AND ANALGESIA
    NIH/NINDS P01NS021445Jan 1, 1985 - Dec 31, 1999
    Role: Co-Investigator
    Function and development in the synapse
    NIH P01NS016033Apr 1, 1980 - Jun 30, 2009
    Role: Co-Investigator
    Brainstem control of pain transmission
    NIH/NINDS R37NS014627Jul 15, 1978 - Jun 30, 2015
    Role: Principal Investigator
    Brainstem control of pain transmission
    NIH/NINDS R01NS014627Jul 1, 1978 - Mar 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Dembo T, Braz JM, Hamel KA, Kuhn JA, Basbaum AI. Primary Afferent-Derived BDNF Contributes Minimally to the Processing of Pain and Itch. eNeuro. 2018 Nov-Dec; 5(6). PMID: 30627644.
      View in: PubMed
    2. Dickie AC, Bell AM, Iwagaki N, Polgár E, Gutierrez-Mecinas M, Kelly R, Lyon H, Turnbull K, West SJ, Etlin A, Braz J, Watanabe M, Bennett DLH, Basbaum AI, Riddell JS, Todd AJ. Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn. Pain. 2018 Sep 20. PMID: 30247267.
      View in: PubMed
    3. Juarez-Salinas DL, Braz JM, Hamel KA, Basbaum AI. Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls. Pain Rep. 2018 Jul-Aug; 3(4):e659. PMID: 30123855.
      View in: PubMed
    4. Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F. NaV1.1 inhibition can reduce visceral hypersensitivity. JCI Insight. 2018 Jun 07; 3(11). PMID: 29875317.
      View in: PubMed
    5. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 May 15. PMID: 29765159.
      View in: PubMed
    6. Wang D, Tawfik VL, Corder G, Low SA, François A, Basbaum AI, Scherrer G. Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron. 2018 Apr 04; 98(1):90-108.e5. PMID: 29576387.
      View in: PubMed
    7. Llewellyn-Smith IJ, Basbaum AI, Bráz JM. Long-term, dynamic synaptic reorganization after GABAergic precursor cell transplantation into adult mouse spinal cord. J Comp Neurol. 2018 Feb 15; 526(3):480-495. PMID: 29134656.
      View in: PubMed
    8. Basbaum A. Chemogenetic management of neuropathic pain. Brain. 2017 Oct 01; 140(10):2522-2525. PMID: 28969393.
      View in: PubMed
    9. Tran M, Kuhn JA, Bráz JM, Basbaum AI. Neuronal aromatase expression in pain processing regions of the medullary and spinal cord dorsal horn. J Comp Neurol. 2017 Nov 01; 525(16):3414-3428. PMID: 28649695.
      View in: PubMed
    10. Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D. Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):E2524-E2532. PMID: 28265084.
      View in: PubMed
    11. Cevikbas F, Braz JM, Wang X, Solorzano C, Sulk M, Buhl T, Steinhoff M, Basbaum AI. Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2017 Aug; 140(2):454-464.e2. PMID: 28232084.
      View in: PubMed
    12. Braz JM, Etlin A, Juarez-Salinas D, Llewellyn-Smith IJ, Basbaum AI. Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch. Prog Brain Res. 2017; 231:87-105. PMID: 28554402.
      View in: PubMed
    13. Etlin A, Bráz JM, Kuhn JA, Wang X, Hamel KA, Llewellyn-Smith IJ, Basbaum AI. Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord. J Neurosci. 2016 11 16; 36(46):11634-11645. PMID: 27852772.
      View in: PubMed
    14. Frezel N, Sohet F, Daneman R, Basbaum AI, Braz JM. Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE. Exp Neurol. 2016 09; 283(Pt A):224-34. PMID: 27343802.
      View in: PubMed
    15. Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D. Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 06 23; 534(7608):494-9. PMID: 27281198.
      View in: PubMed
    16. Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain. 2016 Apr; 157(4):901-9. PMID: 26683237.
      View in: PubMed
    17. Basbaum AI, Bráz JM. Cell transplants to treat the "disease" of neuropathic pain and itch. Pain. 2016 Feb; 157 Suppl 1:S42-7. PMID: 26780378.
      View in: PubMed
    18. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI. Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016 Jan; 19(1):94-101. PMID: 26642091; PMCID: PMC4703328.
    19. Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH. Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli. PLoS One. 2015; 10(12):e0142906. PMID: 26630489; PMCID: PMC4667991.
    20. Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R. Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury. Cell Rep. 2015 Nov 10; 13(6):1246-1257. PMID: 26527000.
      View in: PubMed
    21. Bráz JM, Wang F, Basbaum AI. Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection. PLoS One. 2015; 10(10):e0140681. PMID: 26470056.
      View in: PubMed
    22. Brown JD, Saeed M, Do L, Braz J, Basbaum AI, Iadarola MJ, Wilson DM, Dillon WP. CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine. Sci Transl Med. 2015 Sep 16; 7(305):305ra145. PMID: 26378245; PMCID: PMC4854290.
    23. Villanueva L, Bouhassira D, Dickenson T, Basbaum A, Zimmermann M. In Memoriam Jean-Marie Besson 1938-2014. Eur J Pain. 2015 Aug; 19(7):871-6. PMID: 26173566.
      View in: PubMed
    24. Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI. Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Pain. 2015 Jun; 156(6):1084-91. PMID: 25760475.
      View in: PubMed
    25. Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci. 2015 Jan 14; 35(2):648-57. PMID: 25589759.
      View in: PubMed
    26. Braz JM, Juarez-Salinas D, Ross SE, Basbaum AI. Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch. J Clin Invest. 2014 Aug; 124(8):3612-6. PMID: 25003193; PMCID: PMC4109547.
    27. Braz J, Solorzano C, Wang X, Basbaum AI. Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control. Neuron. 2014 May 07; 82(3):522-36. PMID: 24811377; PMCID: PMC4492533.
    28. Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622. PMID: 24723614.
      View in: PubMed
    29. Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G. Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn. Neuron. 2014 Mar 19; 81(6):1443. PMID: 28898633.
      View in: PubMed
    30. Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron. 2014 Mar 19; 81(6):1312-1327. PMID: 24583022; PMCID: PMC4072501.
    31. Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol. 2014 Feb; 133(2):448-60. PMID: 24373353.
      View in: PubMed
    32. Mandadi S, Hong P, Tran MA, Bráz JM, Colarusso P, Basbaum AI, Whelan PJ. Identification of multisegmental nociceptive afferents that modulate locomotor circuits in the neonatal mouse spinal cord. J Comp Neurol. 2013 Aug 15; 521(12):2870-87. PMID: 23436436.
      View in: PubMed
    33. Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013 Sep; 16(9):1284-90. PMID: 23872594; PMCID: PMC4034143.
    34. Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, Yamanaka H, Rice D, Basbaum AI. Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch. Neuron. 2013 Apr 24; 78(2):312-24. PMID: 23622066; PMCID: PMC3700415.
    35. Gibbs JL, Urban R, Basbaum AI. Paradoxical surrogate markers of dental injury-induced pain in the mouse. Pain. 2013 Aug; 154(8):1358-67. PMID: 23719574; PMCID: PMC3743260.
    36. Zhang J, Cavanaugh DJ, Nemenov MI, Basbaum AI. The modality-specific contribution of peptidergic and non-peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons. J Physiol. 2013 Feb 15; 591(4):1097-110. PMID: 23266932; PMCID: PMC3591717.
    37. Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI. Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain. Neuron. 2012 May 24; 74(4):663-75. PMID: 22632725; PMCID: PMC3361692.
    38. Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16; 479(7373):410-4. PMID: 22094702; PMCID: PMC3226747.
    39. Bráz JM, Ackerman L, Basbaum AI. Sciatic nerve transection triggers release and intercellular transfer of a genetically expressed macromolecular tracer in dorsal root ganglia. J Comp Neurol. 2011 Sep 01; 519(13):2648-57. PMID: 21484801; PMCID: PMC3864657.
    40. Cavanaugh DJ, Chesler AT, Bráz JM, Shah NM, Julius D, Basbaum AI. Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci. 2011 Jul 13; 31(28):10119-27. PMID: 21752988; PMCID: PMC3147010.
    41. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci. 2011 Mar 30; 31(13):5067-77. PMID: 21451044; PMCID: PMC3087977.
    42. Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI. Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity. Pain. 2011 May; 152(5):990-1000. PMID: 21256675; PMCID: PMC3079194.
    43. Sharif-Naeini R, Basbaum AI. Targeting pain where it resides ... In the brain. Sci Transl Med. 2011 Jan 12; 3(65):65ps1. PMID: 21228395.
      View in: PubMed
    44. Mogil JS, Basbaum AI. Introducing the Biennial review of pain. Pain. 2011 Mar; 152(3 Suppl):S1. PMID: 21144660.
      View in: PubMed
    45. Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22296-301. PMID: 21135246; PMCID: PMC3009833.
    46. Shields SD, Moore KD, Phelps PE, Basbaum AI. Olfactory ensheathing glia express aquaporin 1. J Comp Neurol. 2010 Nov 01; 518(21):4329-41. PMID: 20853510; PMCID: PMC2949966.
    47. Shields SD, Cavanaugh DJ, Lee H, Anderson DJ, Basbaum AI. Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors. Pain. 2010 Nov; 151(2):422-9. PMID: 20832171; PMCID: PMC2955806.
    48. Bráz JM, Basbaum AI. Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli. Pain. 2010 Aug; 150(2):290-301. PMID: 20605331; PMCID: PMC2922479.
    49. Faktorovich EG, Basbaum AI. Effect of topical 0.5% morphine on postoperative pain after photorefractive keratectomy. J Refract Surg. 2010 Dec; 26(12):934-41. PMID: 20166624.
      View in: PubMed
    50. Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature. 2009 Dec 03; 462(7273):651-5. PMID: 19915548; PMCID: PMC2810205.
    51. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009 Oct 16; 139(2):267-84. PMID: 19837031; PMCID: PMC2852643.
    52. Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11330-5. PMID: 19564617; PMCID: PMC2708751.
    53. Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O'Donnell D, Kieffer BL, Basbaum AI. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell. 2009 Jun 12; 137(6):1148-59. PMID: 19524516; PMCID: PMC3683597.
    54. Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):9075-80. PMID: 19451647; PMCID: PMC2683885.
    55. Braz JM, Enquist LW, Basbaum AI. Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing. J Comp Neurol. 2009 May 10; 514(2):145-60. PMID: 19274668; PMCID: PMC2696271.
    56. Wang X, Ratnam J, Zou B, England PM, Basbaum AI. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J Neurosci. 2009 Apr 29; 29(17):5508-15. PMID: 19403818; PMCID: PMC2720992.
    57. Basbaum AI. Change is coming! Pain. 2009 Jan; 141(1-2):1. PMID: 19100687.
      View in: PubMed
    58. Ossovskaya VS, Dolganov G, Basbaum AI. Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth. J Neurosci Methods. 2009 Mar 15; 177(2):322-33. PMID: 19026687.
      View in: PubMed
    59. Nikai T, Basbaum AI, Ahn AH. Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31; 139(3):533-40. PMID: 18723285; PMCID: PMC2869302.
    60. Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI. Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. J Neurosci. 2008 Aug 06; 28(32):7936-44. PMID: 18685019; PMCID: PMC3844752.
    61. Braz JM, Basbaum AI. Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits. J Comp Neurol. 2008 Apr 20; 507(6):1990-2003. PMID: 18273889; PMCID: PMC4947410.
    62. Akopians AL, Babayan AH, Beffert U, Herz J, Basbaum AI, Phelps PE. Contribution of the Reelin signaling pathways to nociceptive processing. Eur J Neurosci. 2008 Feb; 27(3):523-37. PMID: 18279306.
      View in: PubMed
    63. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13519-24. PMID: 17684094; PMCID: PMC1948902.
    64. Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007 Jul 12; 448(7150):204-8. PMID: 17538622.
      View in: PubMed
    65. Shields SD, Mazario J, Skinner K, Basbaum AI. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain. 2007 Sep; 131(1-2):8-20. PMID: 17257750.
      View in: PubMed
    66. Mazarío J, Basbaum AI. Contribution of substance P and neurokinin A to the differential injury-induced thermal and mechanical responsiveness of lamina I and V neurons. J Neurosci. 2007 Jan 24; 27(4):762-70. PMID: 17251415.
      View in: PubMed
    67. Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D. Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature. 2006 Nov 09; 444(7116):208-12. PMID: 17093448.
      View in: PubMed
    68. Basbaum AI. Reviews: topical, systematic and once again, comprehensive. Pain. 2006 Oct; 124(3):237. PMID: 16934404.
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    69. Ahn AH, Basbaum AI. Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain. J Neurosci. 2006 Aug 09; 26(32):8332-8. PMID: 16899728; PMCID: PMC1851888.
    70. Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, Kieffer BL. Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9691-6. PMID: 16766653.
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    71. Basbaum AI, Julius D. Toward better pain control. Sci Am. 2006 Jun; 294(6):60-7. PMID: 16711361.
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    72. Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, Wang HY, Jackson SN, Zeitz P, Zeitz KP, Zolkowska D, Schepers R, Nold M, Danielson J, Gräslund A, Vukojevic V, Bakalkin G, Basbaum A, Shippenberg T. Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. J Proteome Res. 2006 Apr; 5(4):1017-23. PMID: 16602711.
      View in: PubMed
    73. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006 Mar 24; 124(6):1269-82. PMID: 16564016.
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    74. Neumann S, Skinner K, Basbaum AI. Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16848-52. PMID: 16275900; PMCID: PMC1283855.
    75. Braz JM, Nassar MA, Wood JN, Basbaum AI. Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron. 2005 Sep 15; 47(6):787-93. PMID: 16157274.
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    76. Julius D, Basbaum AI. A neuropeptide courier for delta-opioid receptors? Cell. 2005 Aug 26; 122(4):496-8. PMID: 16122418.
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    77. Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem. 2005 Sep 09; 280(36):31405-12. PMID: 15987694.
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    78. Ahn AH, Basbaum AI. Where do triptans act in the treatment of migraine? Pain. 2005 May; 115(1-2):1-4. PMID: 15836963; PMCID: PMC1850935.
    79. Basbaum AI. A new way to lose your nerve. Sci Aging Knowledge Environ. 2004 Apr 14; 2004(15):pe15. PMID: 15084736.
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    80. Sanderson Nydahl K, Skinner K, Julius D, Basbaum AI. Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat. Eur J Neurosci. 2004 Apr; 19(7):1789-99. PMID: 15078552.
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    81. Lewinter RD, Skinner K, Julius D, Basbaum AI. Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. J Comp Neurol. 2004 Mar 15; 470(4):400-8. PMID: 14961565.
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    82. Martin WJ, Cao Y, Basbaum AI. Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo. J Neurophysiol. 2004 May; 91(5):1945-54. PMID: 14711972.
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    83. Potrebic S, Ahn AH, Skinner K, Fields HL, Basbaum AI. Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans. J Neurosci. 2003 Nov 26; 23(34):10988-97. PMID: 14645495.
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    84. Shields SD, Eckert WA, Basbaum AI. Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis. J Pain. 2003 Oct; 4(8):465-70. PMID: 14622667.
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    85. Taylor BK, Basbaum AI. Systemic morphine-induced release of serotonin in the rostroventral medulla is not mimicked by morphine microinjection into the periaqueductal gray. J Neurochem. 2003 Sep; 86(5):1129-41. PMID: 12911621.
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    86. Bhatia M, Slavin J, Cao Y, Basbaum AI, Neoptolemos JP. Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2003 May; 284(5):G830-6. PMID: 12684214.
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    87. Malmberg AB, Gilbert H, McCabe RT, Basbaum AI. Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T. Pain. 2003 Jan; 101(1-2):109-16. PMID: 12507705.
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    88. Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, Basbaum AI. Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):271-6. PMID: 12496346; PMCID: PMC140949.
    89. Braz JM, Rico B, Basbaum AI. Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15148-53. PMID: 12391304; PMCID: PMC137558.
    90. Telgkamp P, Cao YQ, Basbaum AI, Ramirez JM. Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network. J Neurophysiol. 2002 Jul; 88(1):206-13. PMID: 12091546.
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    91. Neumann S, Bradke F, Tessier-Lavigne M, Basbaum AI. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron. 2002 Jun 13; 34(6):885-93. PMID: 12086637.
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    92. Abbadie C, Lombard MC, Besson JM, Trafton JA, Basbaum AI. Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions. Brain Res. 2002 Mar 15; 930(1-2):150-62. PMID: 11879805.
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    93. Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci. 2002 Feb 01; 22(3):1010-9. PMID: 11826129.
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