Sakeen Kashem, MD, PhD

Title(s)Assistant Professor, Dermatology
SchoolSchool of Medicine
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-2594-2884 Additional info
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    Collapse Biography 
    Collapse education and training
    New York UniversityBA2008Chemistry
    University of Minnesota PhD2016Immunology
    University of MinnesotaMD2018
    University of Texas SouthwesternInternship2019Internal Medicine
    University of California, San FranciscoResidency2022Dermatology
    University of California, San FranciscoDiversity, Equity, and Inclusion Champion Training

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2411724122. Crowther AJ, Kashem SW, Jewell ME, Le Chang H, Midavaine É, Rosa Casillas M, Danchine V, Rodriguez S, Kania A, Chen R, Braz JM, Basbaum AI. PMID: 40498457.
      View in: PubMed   Mentions:
    2. Meningeal regulatory T cells inhibit nociception in female mice. Science. 2025 Apr 04; 388(6742):96-104. Midavaine É, Moraes BC, Benitez J, Rodriguez SR, Braz JM, Kochhar NP, Eckalbar WL, Tian L, Domingos AI, Pintar JE, Basbaum AI, Kashem SW. PMID: 40179196.
      View in: PubMed   Mentions:    Fields:    
    3. Regulatory T cell-derived enkephalin gates nociception. bioRxiv. 2024 Nov 12. Midavaine É, Moraes BC, Benitez J, Rodriguez SR, Braz JM, Kochhar NP, Eckalbar WL, Domingos AI, Pintar JE, Basbaum AI, Kashem SW. PMID: 38798460; PMCID: PMC11118376.
      View in: PubMed   Mentions:
    4. Discovery of a CCR2-targeting pepducin therapy for chronic pain. Pharmacol Res. 2024 Jul; 205:107242. Midavaine É, Brouillette RL, Théberge E, Mona CE, Kashem SW, Côté J, Zeugin V, Besserer-Offroy É, Longpré JM, Marsault É, Sarret P. PMID: 38823470.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Neuropeptide substance P alters stem cell fate to aid wound healing and promote epidermal stratification through asymmetric stem cell divisions. Stem Cells. 2024 Feb 01. Khalifa A, Xiao T, Abegaze B, Weisenberger T, Charruyer A, Sanad S, AbuElnasr T, Kashem SW, Fassett M, Ghadially R. PMID: 38301639.
      View in: PubMed   Mentions:    Fields:    
    6. Can Serum Biomarkers for Prurigo Nodularis Expose Pathophysiology or Just Treatment Response? JAMA Dermatol. 2023 09 01; 159(9):915-917. Kashem SW, Fassett MS. PMID: 37556170.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch. bioRxiv. 2023; 9(7):548214. Crowther AJ, Kashem SW, Jewell ME, Chang HL, Casillas MR, Midavaine E, Rodriguez S, Braz JM, Kania A, Basbaum AI.
    8. Spontaneous resolution of intractable prurigo nodularis after subinsular cortex stroke. JAAD Case Rep. 2023 Feb; 32:84-87. Kashem SW, Motzkin JC, Leslie KS. PMID: 36687303; PMCID: PMC9851835.
      View in: PubMed   Mentions:
    9. Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells. Sci Immunol. 2022 11 18; 7(77):eabq3254. Whitley SK, Li M, Kashem SW, Hirai T, Igyártó BZ, Knizner K, Ho J, Ferris LK, Weaver CT, Cua DJ, McGeachy MJ, Kaplan DH. PMID: 36367947; PMCID: PMC9847353.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    10. A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity. Cell Rep Med. 2022 08 16; 3(8):100715. Cook CP, Taylor M, Liu Y, Schmidt R, Sedgewick A, Kim E, Hailer A, North JP, Harirchian P, Wang H, Kashem SW, Shou Y, McCalmont TC, Benz SC, Choi J, Purdom E, Marson A, Ramos SBV, Cheng JB, Cho RJ. PMID: 35977472; PMCID: PMC9418858.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Association of Facial Pustular Neutrophilic Eruption With Messenger RNA-1273 SARS-CoV-2 Vaccine. JAMA Dermatol. 2021 09 01; 157(9):1128-1130. Merrill ED, Kashem SW, Amerson EH, Pincus LB, Lang UE, Shinkai K, Chang AY. PMID: 34319363.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    12. Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation. iScience. 2020 Oct 23; 23(10):101582. Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB. PMID: 33205009; PMCID: PMC7648132.
      View in: PubMed   Mentions: 27  
    13. Isolation of Murine Skin Resident and Migratory Dendritic Cells via Enzymatic Digestion. Curr Protoc Immunol. 2018 04; 121(1):e45. Kashem SW, Kaplan DH. PMID: 30040218; PMCID: PMC6060630.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    14. Inflammatory arthritis in pediatric patients with morphea. J Am Acad Dermatol. 2018 Jul; 79(1):47-51.e2. Kashem SW, Correll CK, Vehe RK, Hobday PM, Binstadt BA, Maguiness SM. PMID: 29535035.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Antigen-Presenting Cells in the Skin. Annu Rev Immunol. 2017 04 26; 35:469-499. Kashem SW, Haniffa M, Kaplan DH. PMID: 28226228.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimalsCells
    16. Pathogenic and Protective Autoantibodies in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Antibodies (Basel). 2017 Jan 17; 6(1). Kashem SW, Binstadt BA. PMID: 31548517; PMCID: PMC6698825.
      View in: PubMed   Mentions: 5  
    17. Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection. J Immunol. 2017 02 15; 198(4):1627-1637. Wiesner DL, Smith KD, Kashem SW, Bohjanen PR, Nielsen K. PMID: 28069805; PMCID: PMC5296217.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    18. Brief Report: Arthritis in KRN T Cell Receptor-Transgenic Mice Does Not Require Interleukin-17 or Th17 Cells. Arthritis Rheumatol. 2016 08; 68(8):1849-55. Auger JL, Cowan HM, Engelson BJ, Kashem SW, Prinz I, Binstadt BA. PMID: 26882006; PMCID: PMC4963273.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Skin Immunity to Candida albicans. Trends Immunol. 2016 07; 37(7):440-450. Kashem SW, Kaplan DH. PMID: 27178391; PMCID: PMC4931795.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    20. Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β. Nat Immunol. 2016 Apr; 17(4):414-21. Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. PMID: 26901152; PMCID: PMC5135085.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    21. Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12782-7. Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK. PMID: 26417101; PMCID: PMC4611596.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    22. Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity. Immunity. 2015 Sep 15; 43(3):515-26. Kashem SW, Riedl MS, Yao C, Honda CN, Vulchanova L, Kaplan DH. PMID: 26377898; PMCID: PMC4607048.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    23. Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation. Immunity. 2015 Feb 17; 42(2):356-366. Kashem SW, Igyarto BZ, Gerami-Nejad M, Kumamoto Y, Mohammed JA, Jarrett E, Drummond RA, Zurawski SM, Zurawski G, Berman J, Iwasaki A, Brown GD, Kaplan DH. PMID: 25680275; PMCID: PMC4343045.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    24. Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol. 2015 Feb 15; 194(4):1609-20. Cabrera-Perez J, Condotta SA, James BR, Kashem SW, Brincks EL, Rai D, Kucaba TA, Badovinac VP, Griffith TS. PMID: 25595784; PMCID: PMC4412277.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    25. Langerhans cells require MyD88-dependent signals for Candida albicans response but not for contact hypersensitivity or migration. J Immunol. 2012 May 01; 188(9):4334-9. Haley K, Igyártó BZ, Ortner D, Bobr A, Kashem S, Schenten D, Kaplan DH. PMID: 22442445; PMCID: PMC3331889.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    26. G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2. Eur J Pharmacol. 2011 Oct 01; 668(1-2):299-304. Kashem SW, Subramanian H, Collington SJ, Magotti P, Lambris JD, Ali H. PMID: 21741965; PMCID: PMC3169012.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    27. PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Mol Pharmacol. 2011 Jun; 79(6):1005-13. Subramanian H, Kashem SW, Collington SJ, Qu H, Lambris JD, Ali H. PMID: 21441599; PMCID: PMC3102546.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    28. Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2959-65. Hassan S, Sainz IM, Khan MM, Bradford HN, Isordia-Salas I, Kashem SW, Sartor RB, Colman RW. PMID: 17293494.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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