Rochelle Zak, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
AddressSan Francisco CA 94158
Phone415-885-7886
PronounsShe/Her/Hers
ORCID ORCID Icon0000-0002-8176-8622 Additional info
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    New York HospitalNeurology Residence and Sleep Fellowship
    UCLA School of MedicineMD

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    Dr. Zak is a neurologist who specializes in sleep medicine. She has a particular interest in Restless Legs Syndrome but sees patients with all types of sleep disorders. She believes that her patients should understand their disease as well as she does and enjoys teaching patients about the causes of sleep disorders. Her research is in the area of mid-life women's sleep and she is actively involved in the generation of evidence-based treatment recommendations by the American Academy of Sleep Medicine.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. 0905 Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder: An AASM Clinical Practice Guideline. Sleep. 2025 May 19; 48(Supplement_1):a393-a394. Winkelman WJ, Berkowski BJ, DelRosso DL, Koo KB, Scharf SM, Sharon SD, Zak ZR, Kazmi KU, Falck-Ytter FY, Shelgikar SA, Trotti TL, Walters WA. .
      View in: Publisher Site   Mentions:
    2. Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2025 Jan 01; 21(1):137-152. Winkelman JW, Berkowski JA, DelRosso LM, Koo BB, Scharf MT, Sharon D, Zak RS, Kazmi U, Falck-Ytter Y, Shelgikar AV, Trotti LM, Walters AS. PMID: 39324694; PMCID: PMC11701286.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    3. Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment. J Clin Sleep Med. 2025 Jan 01; 21(1):153-199. Winkelman JW, Berkowski JA, DelRosso LM, Koo BB, Scharf MT, Sharon D, Zak RS, Kazmi U, Carandang G, Falck-Ytter Y, Shelgikar AV, Trotti LM, Walters AS. PMID: 39324664.
      View in: PubMed   Mentions: 2     Fields:    
    4. Dietary Factors Associated with Depressive Symptoms in Midlife Women 40-50 Years of Age Living in the United States. Womens Health Rep (New Rochelle). 2024; 5(1):997-1007. Jones HJ, Ledesma N, Gomez A, Zak R, Lee KA. PMID: 39758527; PMCID: PMC11693945.
      View in: PubMed   Mentions:
    5. Sleep symptoms signaling the menopausal transition. J Clin Sleep Med. 2023 08 01; 19(8):1513-1521. Zak R, Zitser J, Jones HJ, Gilliss CL, Lee KA. PMID: 37086049; PMCID: PMC10394374.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2023 04 01; 19(4):759-768. Howell M, Avidan AY, Foldvary-Schaefer N, Malkani RG, During EH, Roland JP, McCarter SJ, Zak RS, Carandang G, Kazmi U, Ramar K. PMID: 36515157; PMCID: PMC10071384.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    7. Management of REM sleep behavior disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment. J Clin Sleep Med. 2023 04 01; 19(4):769-810. Howell M, Avidan AY, Foldvary-Schaefer N, Malkani RG, During EH, Roland JP, McCarter SJ, Zak RS, Carandang G, Kazmi U, Ramar K. PMID: 36515150; PMCID: PMC10071381.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. Vitamin D deficiency and restless legs syndrome during pregnancy: walking in sunshine? J Clin Sleep Med. 2023 01 01; 19(1):3-4. Lee KA, Gomez A, Zak RS. PMID: 36377836; PMCID: PMC9806791.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Sleep Self-Report and Actigraphy Measures in Healthy Midlife Women: Validity of the Pittsburgh Sleep Quality Index. J Womens Health (Larchmt). 2022 07; 31(7):965-973. Zak RS, Zitser J, Jones HJ, Gilliss CL, Lee KA. PMID: 35230171; PMCID: PMC9299524.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Sleep questionnaire copyright fees can benefit research: a response to Chiang and Folz. Sleep. 2021 12 10; 44(12). Zak RS, Winkelman JW. PMID: 34726232.
      View in: PubMed   Mentions:    Fields:    
    11. The glass is half full: gender diversity in sleep medicine award recognition. J Clin Sleep Med. 2021 08 01; 17(8):1517-1518. Zak RS, Lee KA. PMID: 34047691; PMCID: PMC8656911.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Processed electroencephalography: impact of patient age and surgical position on intraoperative processed electroencephalogram monitoring of burst-suppression. J Clin Monit Comput. 2022 08; 36(4):1099-1107. Pleasants D, Zak R, Ashbrook LH, Zhang L, Tang C, Tran D, Wang M, Tabatabai S, Leung JM. PMID: 34245405; PMCID: PMC11046414.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Supporting American Academy of Neurology's new clinical practice guideline on evaluation and management of insomnia in children with autism. J Clin Sleep Med. 2020 06 15; 16(6):989-990. Rosen CL, Aurora RN, Kapur VK, Ramos AR, Rowley JA, Troester MM, Zak RS. PMID: 32125270; PMCID: PMC7849669.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Sleep disruption is not observed with brain-responsive neurostimulation for epilepsy. Epilepsia Open. 2020 Jun; 5(2):155-165. Ruoff L, Jarosiewicz B, Zak R, Tcheng TK, Neylan TC, Rao VR. PMID: 32524041; PMCID: PMC7278540.
      View in: PubMed   Mentions: 4     Fields:    
    15. Validation of the self-administered version of the international restless legs syndrome study group severity rating scale - the sIRLS. Sleep Medicine. 2019 Dec 1; 64:s346. Sharon SD, Allen AR, Martinez-Martin MP, Walters WA, Strambi SL, Hogl HB, Trotti TL, Buchfuhrer BM, Swieca SJ, Bogan BR, Zak ZR, Hensley HJ, Schaefer SL, Marelli MS, Zucconi ZM, Stefani SA, Holzknecht HE, Olvera OV, Meaklim MH, Laska LI, Becker BP, Group GI. .
      View in: Publisher Site   Mentions:
    16. 0656 Validation of the Self-administered Version of the International Restless Legs Syndrome Study Group Severity Rating Scale - the sIRLS. Sleep. 2019 Apr 13; 42(Supplement_1):a261-a262. Sharon SD, Allen AR, Martinez-Martin MP, Walters WA, Ferini-Strambi FL, Högl HB, Trotti TL, Buchfuhrer BM, Swieca SJ, Bogan BR, Zak ZR, Becker BP. .
      View in: Publisher Site   Mentions:
    17. Validation of the self-administered version of the international Restless Legs Syndrome study group severity rating scale - The sIRLS. Sleep Med. 2019 02; 54:94-100. Sharon D, Allen RP, Martinez-Martin P, Walters AS, Ferini Strambi L, Högl B, Trotti LM, Buchfuhrer M, Swieca J, Bogan RK, Zak R, Hensley JG, Schaefer LA, Marelli S, Zucconi M, Stefani A, Holzknecht E, Olvera V, Meaklim H, Laska I, Becker PM, International RLS Study Group. PMID: 30529783.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    18. Sleep Disturbances in Midlife Women at the Cusp of the Menopausal Transition. J Clin Sleep Med. 2018 07 15; 14(7):1127-1133. Jones HJ, Zak R, Lee KA. PMID: 29991421; PMCID: PMC6040789.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    19. Position Paper for the Treatment of Nightmare Disorder in Adults: An American Academy of Sleep Medicine Position Paper. J Clin Sleep Med. 2018 06 15; 14(6):1041-1055. Morgenthaler TI, Auerbach S, Casey KR, Kristo D, Maganti R, Ramar K, Zak R, Kartje R. PMID: 29852917; PMCID: PMC5991964.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    20. Burst-suppression ratio underestimates absolute duration of electroencephalogram suppression compared with visual analysis of intraoperative electroencephalogram. Br J Anaesth. 2017 May 01; 118(5):755-761. Muhlhofer WG, Zak R, Kamal T, Rizvi B, Sands LP, Yuan M, Zhang X, Leung JM. PMID: 28486575; PMCID: PMC6224027.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    21. World Association of Sleep Medicine (WASM) 2016 standards for recording and scoring leg movements in polysomnograms developed by a joint task force from the International and the European Restless Legs Syndrome Study Groups (IRLSSG and EURLSSG). Sleep Med. 2016 10; 26:86-95. Ferri R, Fulda S, Allen RP, Zucconi M, Bruni O, Chokroverty S, Ferini-Strambi L, Frauscher B, Garcia-Borreguero D, Hirshkowitz M, Högl B, Inoue Y, Jahangir A, Manconi M, Marcus CL, Picchietti DL, Plazzi G, Winkelman JW, Zak RS, International and European Restless Legs Syndrome Study Groups (IRLSSG and EURLSSG). PMID: 27890390.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    22. Keep Calm and Debate On. J Clin Sleep Med. 2016 09 15; 12(9):1315-6. Aurora RN, Bista SR, Casey KR, Chowdhuri S, Kristo DA, Mallea JM, Ramar K, Rowley JA, Zak RS, Heald JL. PMID: 27568903; PMCID: PMC4990959.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Anesth Analg. 2016 07; 123(1):206-12. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM. PMID: 27159066; PMCID: PMC5493322.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    24. Updated Adaptive Servo-Ventilation Recommendations for the 2012 AASM Guideline: "The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses". J Clin Sleep Med. 2016 05 15; 12(5):757-61. Aurora RN, Bista SR, Casey KR, Chowdhuri S, Kristo DA, Mallea JM, Ramar K, Rowley JA, Zak RS, Heald JL. PMID: 27092695; PMCID: PMC4865563.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    25. Dopaminergic Therapy for Restless Legs Syndrome/Willis-Ekbom Disease. Sleep Med Clin. 2015 Sep; 10(3):279-85, xiii. Zak RS, Walters AS. PMID: 26329437.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Quality measures for the care of adult patients with restless legs syndrome. J Clin Sleep Med. 2015 Mar 15; 11(3):293-310. Trotti LM, Goldstein CA, Harrod CG, Koo BB, Sharon D, Zak R, Chervin RD. PMID: 25700882; PMCID: PMC4346652.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. Cytokine polymorphisms and plasma levels are associated with sleep onset insomnia in adults living with HIV/AIDS. Brain Behav Immun. 2015 Jul; 47:58-65. Gay CL, Zak RS, Lerdal A, Pullinger CR, Aouizerat BE, Lee KA. PMID: 25535857; PMCID: PMC4468032.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    28. Cytokine polymorphisms are associated with poor sleep maintenance in adults living with human immunodeficiency virus/acquired immunodeficiency syndrome. Sleep. 2014 Mar 01; 37(3):453-63. Lee KA, Gay C, Pullinger CR, Hennessy MD, Zak RS, Aouizerat BE. PMID: 24587567; PMCID: PMC3920310.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    29. The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults—An Update for 2012: Practice Parameters with an Evidence-Based Systematic Review and Meta-Analyses. FOCUS The Journal of Lifelong Learning in Psychiatry. 2014 Jan 1; 12(1):99-121. Aurora AR, Kristo KD, Bista BS, Rowley RJ, Zak ZR, Casey CK, Lamm LC, Tracy TS, Rosenberg RR. .
      View in: Publisher Site   Mentions:
    30. Polymorphisms of interleukin-1 Beta and interleukin-17Alpha genes are associated with restless legs syndrome. Biol Res Nurs. 2014 Apr; 16(2):143-51. Hennessy MD, Zak RS, Gay CL, Pullinger CR, Lee KA, Aouizerat BE. PMID: 23460603; PMCID: PMC5697711.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    31. Practice parameters for the non-respiratory indications for polysomnography and multiple sleep latency testing for children. Sleep. 2012 Nov 01; 35(11):1467-73. Aurora RN, Lamm CI, Zak RS, Kristo DA, Bista SR, Rowley JA, Casey KR. PMID: 23115395; PMCID: PMC3466793.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    32. Treatment of Central Sleep Apnea Syndromes. Sleep. 2012 Sep 1; 35(9):1199-1199. Ramar RK, Aurora AR, Chowdhuri CS, Bista BS, Casey CK, Lamm LC, Kristo KD, Mallea MJ, Rowley RJ, Zak ZR, Tracy TS. .
      View in: Publisher Site   Mentions:
    33. Update to the AASM Clinical Practice Guideline: "The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses". Sleep. 2012 Aug 01; 35(8):1037. Aurora RN, Kristo DA, Bista SR, Rowley JA, Zak RS, Casey KR, Lamm CI, Tracy SL, Rosenberg RS. PMID: 22851800; PMCID: PMC3397810.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    34. The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep. 2012 Aug 01; 35(8):1039-62. Aurora RN, Kristo DA, Bista SR, Rowley JA, Zak RS, Casey KR, Lamm CI, Tracy SL, Rosenberg RS, American Academy of Sleep Medicine. PMID: 22851801; PMCID: PMC3397811.
      View in: PubMed   Mentions: 100     Fields:    Translation:Humans
    35. What can be learned from high-resolution sleep data using ECoG. BMC Neuroscience. 2012 Jul 1; 13(Suppl 1):p94. Dadok DV, Szeri SA, Kirsch KH, Sleigh SJ, Zak ZR, Lopour LB. .
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    36. The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses. Sleep. 2012 Jan 01; 35(1):17-40. Aurora RN, Chowdhuri S, Ramar K, Bista SR, Casey KR, Lamm CI, Kristo DA, Mallea JM, Rowley JA, Zak RS, Tracy SL. PMID: 22215916; PMCID: PMC3242685.
      View in: PubMed   Mentions: 116     Fields:    Translation:Humans
    37. Revisiting Evidence-Based Guidelines: Not Such a Nightmare. Journal of Clinical Sleep Medicine. 2011 Oct 15. Aurora AR, Zak ZR, Auerbach AS, Casey CK, Chowdhuri CS, Karippot KA, Maganti MR, Ramar RK, Kristo KD, Bista BS, Lamm LC, Morgenthaler MT. .
      View in: Publisher Site   Mentions:
    38. Practice parameters for the respiratory indications for polysomnography in children. Sleep. 2011 Mar 01; 34(3):379-88. Aurora RN, Zak RS, Karippot A, Lamm CI, Morgenthaler TI, Auerbach SH, Bista SR, Casey KR, Chowdhuri S, Kristo DA, Ramar K, American Academy of Sleep Medicine. PMID: 21359087; PMCID: PMC3041715.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    39. Practice parameters for the surgical modifications of the upper airway for obstructive sleep apnea in adults. Sleep. 2010 Oct; 33(10):1408-13. Aurora RN, Casey KR, Kristo D, Auerbach S, Bista SR, Chowdhuri S, Karippot A, Lamm C, Ramar K, Zak R, Morgenthaler TI, American Academy of Sleep Medicine. PMID: 21061864; PMCID: PMC2941428.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    40. Best practice guide for the treatment of nightmare disorder in adults. J Clin Sleep Med. 2010 Aug 15; 6(4):389-401. Aurora RN, Zak RS, Auerbach SH, Casey KR, Chowdhuri S, Karippot A, Maganti RK, Ramar K, Kristo DA, Bista SR, Lamm CI, Morgenthaler TI, Standards of Practice Committee, American Academy of Sleep Medicine. PMID: 20726290; PMCID: PMC2919672.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    41. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med. 2010 Feb 15; 6(1):85-95. Aurora RN, Zak RS, Maganti RK, Auerbach SH, Casey KR, Chowdhuri S, Karippot A, Ramar K, Kristo DA, Morgenthaler TI, Standards of Practice Committee, American Academy of Sleep Medicine. PMID: 20191945; PMCID: PMC2823283.
      View in: PubMed   Mentions: 129     Fields:    Translation:Humans
    42. Preliminary study of the prevalence of restless legs syndrome in adults with attention deficit hyperactivity disorder. Percept Mot Skills. 2009 Jun; 108(3):759-63. Zak R, Fisher B, Couvadelli BV, Moss NM, Walters AS. PMID: 19725311.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    43. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of Sleep Medicine report. Sleep. 2008 Jan; 31(1):141-7. Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, Chesson AL, Friedman L, Kapur V, Maganti R, Owens J, Pancer J, Swick TJ, Standards of Practice Committee of the AASM, American Academy of Sleep Medicine. PMID: 18220088; PMCID: PMC2225554.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    44. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007 Dec; 30(12):1705-11. Morgenthaler TI, Kapur VK, Brown T, Swick TJ, Alessi C, Aurora RN, Boehlecke B, Chesson AL, Friedman L, Maganti R, Owens J, Pancer J, Zak R, Standards of Practice Committee of the American Academy of Sleep Medicine. PMID: 18246980; PMCID: PMC2276123.
      View in: PubMed   Mentions: 125     Fields:    Translation:Humans
    45. Practice Parameters for the Treatment of Narcolepsy and other Hypersomnias of Central Origin. Sleep. 2007 Dec 1; 30(12):1705-s9. Morgenthaler MT, Kapur KV, Brown BT, Swick ST, Alessi AC, Aurora AR, Boehlecke BB, Chesson CA, Friedman FL, Maganti MR, Owens OJ, Pancer PJ, Zak ZR. .
      View in: Publisher Site   Mentions:
    46. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Sleep. 2007 Nov; 30(11):1445-59. Morgenthaler TI, Lee-Chiong T, Alessi C, Friedman L, Aurora RN, Boehlecke B, Brown T, Chesson AL, Kapur V, Maganti R, Owens J, Pancer J, Swick TJ, Zak R, Standards of Practice Committee of the American Academy of Sleep Medicine. PMID: 18041479; PMCID: PMC2082098.
      View in: PubMed   Mentions: 147     Fields:    Translation:Humans
    47. The Impact of Life Cycle on Sleep in Women. . 2006 Jan 1; 29-45. Moline MM, Broch BL, Zak ZR. .
      View in: Publisher Site   Mentions:
    48. Sleep in women across the life cycle from adulthood through menopause. Med Clin North Am. 2004 May; 88(3):705-36, ix. Moline ML, Broch L, Zak R. PMID: 15087212.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    49. Sleep in women across the life cycle from adulthood through menopause. Sleep Med Rev. 2003 Apr; 7(2):155-77. Moline ML, Broch L, Zak R, Gross V. PMID: 12628216.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    50. Quipazine has a biphasic effect on slow wave sleep and reduces REM sleep rebound in REM sleep deprived rats. Brain Res Bull. 1982 Mar; 8(3):329-31. Zak R, Radulovacki M. PMID: 7093740.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    51. Amphetamine abolishes REM sleep rebound in rats: effect of single injection. Brain Res. 1981 Aug 03; 217(2):420-4. Radulovacki M, Zak R. PMID: 7248800.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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