Jacqueline Leung, MD, MPH

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address521 Parnassus Avenue, #4228
San Francisco CA 94117
Phone415-476-0711
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Clinical Fellowship Cardiology
    University of California, San FranciscoResidency
    Stanford UniversityM.D.1984School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Leung is the director of the Perioperative Medicine Research Group based at UCSF Medical Center. The group conducts outcomes research in older surgical patients. Our recent work focuses on identifying the pathophysiology of postoperative delirium and cognitive decline, and also the mechanism between sleep disruption and ICU delirium.

    Collapse Research 
    Collapse Research Activities and Funding
    The role of genomics in postoperative delirium and sedation
    NIH R01NR017622Sep 24, 2019 - Jul 31, 2022
    Role: Principal Investigator
    Acute preoperative sleep disruption and postoperative delirium
    NIH R21AG053715Mar 1, 2017 - Feb 29, 2020
    Role: Principal Investigator
    The Effects of Light vs Deep Anesthesia on Postoperative Cognitive Outcomes
    NIH R21AG048456Jun 1, 2015 - May 31, 2018
    Role: Principal Investigator
    Pathophysiology of postoperative delirium in older patients
    NIH R01AG031795Sep 15, 2009 - Jul 31, 2015
    Role: Principal Investigator
    AGING AND PERIOPERATIVE OUTCOMES
    NIH K24AG000948Mar 1, 2001 - Feb 28, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Multi-level social determinants of health, inflammation, and postoperative delirium in older adults. J Am Geriatr Soc. 2024 Aug 29. Vasunilashorn SM, Wolfson E, Berger M, Leung J, Ware EB, Baccarelli A, Jones RN, Ngo LH, Marcantonio ER, Inouye SK, Kind AJH. PMID: 39206865.
      View in: PubMed   Mentions:
    2. Plasma SOMAmer proteomics of postoperative delirium. Brain Behav. 2024 02; 14(2):e3422. Leung JM, Rojas JC, Sands LP, Chan B, Rajbanshi B, Du Z, Du P, Perioperative Medicine Research group. PMID: 38346717; PMCID: PMC10861352.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals. Front Immunol. 2024; 15:1348041. Leung JM, Wu MJ, Kheradpour P, Chen C, Drake KA, Tong G, Ridaura VK, Zisser HC, Conrad WA, Hudson N, Allen J, Welberry C, Parsy-Kowalska C, Macdonald I, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Basit M, Krishnan JA, Parthasarathy S, Prabhakar BS, Salvatore M, Kim CC. PMID: 38318183; PMCID: PMC10838987.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Assessing patterns of delirium symptoms reveals a novel subtype among elective surgical patients with postoperative delirium. Int J Geriatr Psychiatry. 2024 Jan; 39(1):e6049. Yang L, Do Q, Zhu X, Leung JM, Perioperative Medicine Research Group, Sands LP. PMID: 38168022.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Multi-omic profiling reveals early immunological indicators for identifying COVID-19 Progressors. Clin Immunol. 2023 11; 256:109808. Drake KA, Talantov D, Tong GJ, Lin JT, Verheijden S, Katz S, Leung JM, Yuen B, Krishna V, Wu MJ, Sutherland AM, Short SA, Kheradpour P, Mumbach MR, Franz KM, Trifonov V, Lucas MV, Merson J, Kim CC, PRESCO Study Group. PMID: 37852344.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Distinct temporal trajectories and risk factors for Post-acute sequelae of SARS-CoV-2 infection. Front Med (Lausanne). 2023; 10:1227883. Chen C, Parthasarathy S, Leung JM, Wu MJ, Drake KA, Ridaura VK, Zisser HC, Conrad WA, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Prabhakar BS, Basit M, Salvatore M, Krishnan JA, Kim CC. PMID: 37908849; PMCID: PMC10614284.
      View in: PubMed   Mentions:
    7. Presence of Preoperative Neurodegeneration Biofluid Markers in Patients with Postoperative Delirium. Anesthesiology. 2023 10 01; 139(4):432-443. Leung JM, Rojas JC, Tang C, Chan B, Lario-Lago A, Boxer AL, Do Q, Kramer JH, Du Z, Du P, Sands LP, Perioperative Medicine Research Group. PMID: 37364279; PMCID: PMC10529495.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Fine structure and molecular characterization of two new parabasalid species that naturally colonize laboratory mice, Tritrichomonas musculus and Tritrichomonas casperi. J Eukaryot Microbiol. 2023 Nov-Dec; 70(6):e12989. Tuzlak L, Alves-Ferreira EVC, Schwartz CL, Kennard A, Leung JM, Shehata C, Grigg ME. PMID: 37300520.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19. Nat Commun. 2023 07 25; 14(1):4481. Robertson SJ, Bedard O, McNally KL, Shaia C, Clancy CS, Lewis M, Broeckel RM, Chiramel AI, Shannon JG, Sturdevant GL, Rosenke R, Anzick SL, Forte E, Preuss C, Baker CN, Harder JM, Brunton C, Munger S, Bruno DP, Lack JB, Leung JM, Shamsaddini A, Gardina P, Sturdevant DE, Sun J, Martens C, Holland SM, Rosenthal NA, Best SM. PMID: 37491352; PMCID: PMC10368652.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Multi-omic Profiling Reveals Early Immunological Indicators for Identifying COVID-19 Progressors. bioRxiv. 2023 May 26. Drake KA, Talantov D, Tong GJ, Lin JT, Verheijden S, Katz S, Leung JM, Yuen B, Krishna V, Wu MJ, Sutherland A, Short SA, Kheradpour P, Mumbach M, Franz K, Trifonov V, Lucas MV, Merson J, Kim CC, PRESCO Study Group . PMID: 37292797; PMCID: PMC10246026.
      View in: PubMed   Mentions:
    11. Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19. bioRxiv. 2023 Apr 21. Robertson S, Bedard O, McNally K, Shaia C, Clancy C, Lewis M, Broeckel R, Chiramel A, Shannon JG, Sturdevant G, Rosenke R, Anzick SL, Forte E, Preuss C, Baker C, Harder J, Brunton C, Munger SC, Bruno DP, Lack JB, Leung JM, Shamsaddini A, Gardina P, Sturdevant D, Sun J, Martens C, Holland S, Rosenthal N, Best S. PMID: 35233576; PMCID: PMC8887079.
      View in: PubMed   Mentions:
    12. Sleep Loss the night before surgery and incidence of postoperative delirium in adults 65-95 years of age. Sleep Med. 2023 05; 105:61-67. Leung JM, Tang C, Do Q, Sands LP, Tran D, Lee KA, Perioperative Medicine Research Group. PMID: 36966577; PMCID: PMC10431933.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge. EBioMedicine. 2022 Aug; 82:104188. Leventhal SS, Meade-White K, Rao D, Haddock E, Leung J, Scott D, Archer J, Randall S, Erasmus JH, Feldmann H, Hawman DW. PMID: 35907368; PMCID: PMC9335360.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    14. Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial. BMJ Open. 2022 06 06; 12(6):e059416. Buren MA, Theologis A, Zuraek A, Behrends M, Clark AJ, Leung JM. PMID: 35667730; PMCID: PMC9171272.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    15. KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients. Sci Rep. 2022 Jan 11; 12(1):556. Terrelonge M, LaHue SC, Tang C, Movsesyan I, Pullinger CR, Dubal DB, Leung J, Douglas VC. PMID: 35017578; PMCID: PMC8752781.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Postoperative delirium prediction using machine learning models and preoperative electronic health record data. BMC Anesthesiol. 2022 01 03; 22(1):8. Bishara A, Chiu C, Whitlock EL, Douglas VC, Lee S, Butte AJ, Leung JM, Donovan AL. PMID: 34979919; PMCID: PMC8722098.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    17. A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis. PLoS Pathog. 2021 12; 17(12):e1009678. Broeckel RM, Feldmann F, McNally KL, Chiramel AI, Sturdevant GL, Leung JM, Hanley PW, Lovaglio J, Rosenke R, Scott DP, Saturday G, Bouamr F, Rasmussen AL, Robertson SJ, Best SM. PMID: 34855915; PMCID: PMC8638978.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Further Insight into the Mechanism of Human PMN Lysis following Phagocytosis of Staphylococcus aureus. Microbiol Spectr. 2021 10 31; 9(2):e0088821. Rungelrath V, Porter AR, Malachowa N, Freedman BA, Leung JM, Voyich JM, Otto M, Kobayashi SD, DeLeo FR. PMID: 34704790; PMCID: PMC8549732.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons. Nat Microbiol. 2021 11; 6(11):1398-1409. Ojha D, Winkler CW, Leung JM, Woods TA, Chen CZ, Nair V, Taylor K, Yeh CD, Tawa GJ, Larson CL, Zheng W, Haigh CL, Peterson KE. PMID: 34675384.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Midazolam Premedication Immediately Before Surgery Is Not Associated With Early Postoperative Delirium. Anesth Analg. 2021 09 01; 133(3):765-771. Wang ML, Min J, Sands LP, Leung JM, the Perioperative Medicine Research Group . PMID: 33721875; PMCID: PMC8373629.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. The Impact of Surgery duration and Surgery End Time on Postoperative Sleep in Older Adults. J Sleep Disord Manag. 2021; 7(2). Tran D, Tang C, Tabatabai S, Pleasants D, Choukalas C, Min J, Do Q, Sands L, Lee K, Leung JM. PMID: 34604869; PMCID: PMC8486301.
      View in: PubMed   Mentions:
    22. Obesity and perioperative outcomes in older surgical patients undergoing elective spine and major arthroplasty surgery. J Clin Anesth. 2021 12; 75:110475. Tabatabai S, Do Q, Min J, Tang CJ, Pleasants D, Sands LP, Du P, Leung JM. PMID: 34352602; PMCID: PMC11046412.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses. Acta Neuropathol Commun. 2021 01 29; 9(1):17. Striebel JF, Race B, Leung JM, Schwartz C, Chesebro B. PMID: 33509294; PMCID: PMC7845122.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. Does postoperative delirium following elective noncardiac surgery predict long-term mortality? Age Ageing. 2020 10 23; 49(6):1020-1027. Ziman N, Sands LP, Tang C, Zhu J, Leung JM. PMID: 32232435; PMCID: PMC7583520.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. ADAPT-2: A Randomized Clinical Trial to Reduce Intraoperative EEG Suppression in Older Surgical Patients Undergoing Major Noncardiac Surgery. Anesth Analg. 2020 10; 131(4):1228-1236. Tang CJ, Jin Z, Sands LP, Pleasants D, Tabatabai S, Hong Y, Leung JM. PMID: 32925344; PMCID: PMC7599075.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    26. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Delirium Prevention. Anesth Analg. 2020 06; 130(6):1572-1590. Hughes CG, Boncyk CS, Culley DJ, Fleisher LA, Leung JM, McDonagh DL, Gan TJ, McEvoy MD, Miller TE, Perioperative Quality Initiative (POQI) 6 Workgroup. PMID: 32022748; PMCID: PMC7379173.
      View in: PubMed   Mentions: 87     Fields:    Translation:Humans
    27. ADAPT-2: A Randomized Clinical Trial to Reduce Intraoperative EEG Suppression in Older Surgical Patients Undergoing Major Noncardiac Surgery. Anesth Analg. 2020 Mar 09. Tang CJ, Jin Z, Sands LP, Pleasants D, Tabatabai S, Hong Y, Leung JM. PMID: 32167975.
      View in: PubMed   Mentions:    Fields:    
    28. Adherence to recommended practices for perioperative anesthesia care for older adults among US anesthesiologists: results from the ASA Committee on Geriatric Anesthesia-Perioperative Brain Health Initiative ASA member survey. Perioper Med (Lond). 2020; 9:6. Deiner S, Fleisher LA, Leung JM, Peden C, Miller T, Neuman MD, ASA Committee on Geriatric Anesthesia and the ASA Perioperative Brain Health Initiative. PMID: 32123562; PMCID: PMC7041201.
      View in: PubMed   Mentions: 18  
    29. Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis. Anesthesiology. 2018 09; 129(3):417-427. MacKenzie KK, Britt-Spells AM, Sands LP, Leung JM. PMID: 29912008; PMCID: PMC6092196.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    30. Volatile anaesthetics and postoperative delirium in older surgical patients-A secondary analysis of prospective cohort studies. Acta Anaesthesiol Scand. 2019 01; 63(1):18-26. Kinjo S, Lim E, Magsaysay MV, Sands LP, Leung JM, Perioperative Medicine Research Group. PMID: 30051465; PMCID: PMC6283682.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. Anesthesiology. 2017 10; 127(4):633-644. Leung JM, Sands LP, Chen N, Ames C, Berven S, Bozic K, Burch S, Chou D, Covinsky K, Deviren V, Kinjo S, Kramer JH, Ries M, Tay B, Vail T, Weinstein P, Chang S, Meckler G, Newman S, Tsai T, Voss V, Youngblom E, Perioperative Medicine Research Group. PMID: 28727581; PMCID: PMC5605447.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    32. Validation of a Nurse-Based Delirium-Screening Tool for Hospitalized Patients. Psychosomatics. 2017 Nov - Dec; 58(6):594-603. Hargrave A, Bastiaens J, Bourgeois JA, Neuhaus J, Josephson SA, Chinn J, Lee M, Leung J, Douglas V. PMID: 28750835; PMCID: PMC5798858.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansPHPublic Health
    33. Burst-suppression ratio underestimates absolute duration of electroencephalogram suppression compared with visual analysis of intraoperative electroencephalogram. Br J Anaesth. 2017 May 01; 118(5):755-761. Muhlhofer WG, Zak R, Kamal T, Rizvi B, Sands LP, Yuan M, Zhang X, Leung JM. PMID: 28486575; PMCID: PMC6224027.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    34. The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Anesth Analg. 2016 07; 123(1):206-12. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM. PMID: 27159066; PMCID: PMC5493322.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Preoperative Sleep Disruption and Postoperative Delirium. J Clin Sleep Med. 2015 Aug 15; 11(8):907-13. Leung JM, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K. PMID: 25979094; PMCID: PMC4513268.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    36. Prognostic Significance of Postoperative Subsyndromal Delirium. Psychosomatics. 2015 Nov-Dec; 56(6):644-51. Shim J, DePalma G, Sands LP, Leung JM. PMID: 26198571; PMCID: PMC4644721.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    37. Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Br J Anaesth. 2015 Sep; 115(3):418-26. Hirsch J, DePalma G, Tsai TT, Sands LP, Leung JM. PMID: 25616677; PMCID: PMC4533731.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    38. Sensitivity and specificity of the animal fluency test for predicting postoperative delirium. Can J Anaesth. 2015 Jun; 62(6):603-8. Long LS, Wolpaw JT, Leung JM. PMID: 25537737; PMCID: PMC7375858.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    39. American Geriatrics Society abstracted clinical practice guideline for postoperative delirium in older adults. J Am Geriatr Soc. 2015 Jan; 63(1):142-50. American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults. PMID: 25495432; PMCID: PMC5901697.
      View in: PubMed   Mentions: 141     Fields:    Translation:Humans
    40. Postoperative delirium in older adults: best practice statement from the American Geriatrics Society. J Am Coll Surg. 2015 Feb; 220(2):136-48.e1. American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults. PMID: 25535170.
      View in: PubMed   Mentions: 140     Fields:    Translation:Humans
    41. The temporal relationship between early postoperative delirium and postoperative cognitive dysfunction in older patients: a prospective cohort study. Can J Anaesth. 2014 Dec; 61(12):1084-92. Youngblom E, DePalma G, Sands L, Leung J. PMID: 25287962; PMCID: PMC7377300.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    42. Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium? Am J Geriatr Psychiatry. 2013 Oct; 21(10):946-56. Leung JM, Sands LP, Lim E, Tsai TL, Kinjo S. PMID: 23659900; PMCID: PMC3742555.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    43. Association between intraoperative blood transfusions and early postoperative delirium in older adults. J Am Geriatr Soc. 2013 Mar; 61(3):365-70. Behrends M, DePalma G, Sands L, Leung J. PMID: 23496244; PMCID: PMC4529289.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    44. Impact of missing data on analysis of postoperative cognitive decline (POCD). Appl Nurs Res. 2013 May; 26(2):71-5. DeCrane SK, Sands LP, Young KM, DePalma G, Leung JM. PMID: 23290047; PMCID: PMC3620895.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. An update on delirium in the postoperative setting: prevention, diagnosis and management. Best Pract Res Clin Anaesthesiol. 2012 Sep; 26(3):327-43. Shim JJ, Leung JM. PMID: 23040284.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    46. A brief review of practical preoperative cognitive screening tools. Can J Anaesth. 2012 Aug; 59(8):798-804. Long LS, Shapiro WA, Leung JM. PMID: 22638676; PMCID: PMC3711831.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    47. Does using a femoral nerve block for total knee replacement decrease postoperative delirium? BMC Anesthesiol. 2012 Mar 10; 12:4. Kinjo S, Lim E, Sands LP, Bozic KJ, Leung JM. PMID: 22405052; PMCID: PMC3364862.
      View in: PubMed   Mentions: 11     Fields:    
    48. Prediction of postoperative pain using path analysis in older patients. J Anesth. 2012 Feb; 26(1):1-8. Kinjo S, Sands LP, Lim E, Paul S, Leung JM. PMID: 22012171; PMCID: PMC3720127.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    49. Perioperative cognitive decline in the aging population. Mayo Clin Proc. 2011 Sep; 86(9):885-93. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M. PMID: 21878601; PMCID: PMC3257991.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    50. Factors associated with recovery from early postoperative delirium. J Perianesth Nurs. 2011 Aug; 26(4):231-41. DeCrane SK, Sands L, Ashland M, Lim E, Tsai TL, Paul S, Leung JM. PMID: 21803271; PMCID: PMC3148485.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    51. Brief report: preoperative frailty in older surgical patients is associated with early postoperative delirium. Anesth Analg. 2011 May; 112(5):1199-201. Leung JM, Tsai TL, Sands LP. PMID: 21372278; PMCID: PMC3081949.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    52. Postoperative delirium: are there modifiable risk factors? Eur J Anaesthesiol. 2010 May; 27(5):403-5. Leung JM. PMID: 20386385.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    53. Long-term cognitive decline: is there a link to surgery and anesthesia? Anesthesiology. 2009 Nov; 111(5):931-2. Leung JM, Sands LP. PMID: 19786857.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    54. Does postoperative delirium limit the use of patient-controlled analgesia in older surgical patients? Anesthesiology. 2009 Sep; 111(3):625-31. Leung JM, Sands LP, Paul S, Joseph T, Kinjo S, Tsai T. PMID: 19672166; PMCID: PMC2762324.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    55. Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology. 2007 Sep; 107(3):406-11. Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR. PMID: 17721242.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    56. The effects of postoperative pain and its management on postoperative cognitive dysfunction. Am J Geriatr Psychiatry. 2007 Jan; 15(1):50-9. Wang Y, Sands LP, Vaurio L, Mullen EA, Leung JM. PMID: 17194815.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    57. Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery. Cardiology. 2007; 108(2):90-6. Nakai T, Chandy J, Nakai K, Bellows WH, Flachsbart K, Lee RJ, Leung JM. PMID: 17008797.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    58. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology. 2006 Oct 10; 67(7):1251-3. Leung JM, Sands LP, Rico M, Petersen KL, Rowbotham MC, Dahl JB, Ames C, Chou D, Weinstein P. PMID: 16914695.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    59. Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients. Br J Anaesth. 2006 Jun; 96(6):754-60. Leung JM, Sands LP, Vaurio LE, Wang Y. PMID: 16670110.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    60. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006 Apr; 102(4):1267-73. Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung JM. PMID: 16551935.
      View in: PubMed   Mentions: 123     Fields:    Translation:Humans
    61. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg. 2006 Apr; 102(4):1255-66. Fong HK, Sands LP, Leung JM. PMID: 16551934.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    62. Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients? J Gerontol A Biol Sci Med Sci. 2005 Dec; 60(12):1563-8. Leung JM, Sands LP, Mullen EA, Wang Y, Vaurio L. PMID: 16424289.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    63. Post-CABG dobutamine stress echocardiography. Anesth Analg. 2005 Jun; 100(6):1861. Leung JM, Bellows WH. PMID: 15920233.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    64. Impairment of left atrial function predicts post-operative atrial fibrillation after coronary artery bypass graft surgery. Eur Heart J. 2004 Oct; 25(20):1836-44. Leung JM, Bellows WH, Schiller NB. PMID: 15474699.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    65. Does intraoperative evaluation of left ventricular contractile reserve predict myocardial viability? A clinical study using dobutamine stress echocardiography in patients undergoing coronary artery bypass graft surgery. Anesth Analg. 2004 Sep; 99(3):647-654. Leung JM, Bellows WH, Pastor D. PMID: 15333387.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    66. Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery. Anesth Analg. 2004 Feb; 98(2):303-310. Chandy J, Nakai T, Lee RJ, Bellows WH, Dzankic S, Leung JM. PMID: 14742359.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    67. The prevalence of preoperative diastolic filling abnormalities in geriatric surgical patients. Anesth Analg. 2003 Nov; 97(5):1214-1221. Phillip B, Pastor D, Bellows W, Leung JM. PMID: 14570626.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    68. Prognostic significance of postoperative in-hospital complications in elderly patients. I. Long-term survival. Anesth Analg. 2003 Feb; 96(2):583-9, table of contents. Manku K, Bacchetti P, Leung JM. PMID: 12538216.
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    69. Prognostic significance of postoperative in-hospital complications in elderly patients. II. Long-term quality of life. Anesth Analg. 2003 Feb; 96(2):590-4, table of contents. Manku K, Leung JM. PMID: 12538217.
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    70. Preoperative electrocardiogram abnormalities do not predict postoperative cardiac complications in geriatric surgical patients. J Am Geriatr Soc. 2002 Jul; 50(7):1186-91. Liu LL, Dzankic S, Leung JM. PMID: 12133011.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    71. Comparison of left atrial dimensions by transesophageal and transthoracic echocardiography. J Am Soc Echocardiogr. 2002 Feb; 15(2):143-9. Block M, Hourigan L, Bellows WH, Reeves J, Romson JL, Tran M, Pastor D, Schiller NB, Leung JM. PMID: 11836489.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    72. The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery. Am Heart J. 2002 Jan; 143(1):181-6. Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J, Romson J, Ferguson S, Leung JM. PMID: 11773931.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    73. The prevalence and predictors of the use of alternative medicine in presurgical patients in five California hospitals. Anesth Analg. 2001 Oct; 93(4):1062-8. Leung JM, Dzankic S, Manku K, Yuan S. PMID: 11574384.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    74. Relative importance of preoperative health status versus intraoperative factors in predicting postoperative adverse outcomes in geriatric surgical patients. J Am Geriatr Soc. 2001 Aug; 49(8):1080-5. Leung JM, Dzankic S. PMID: 11555070.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    75. The prevalence and predictive value of abnormal preoperative laboratory tests in elderly surgical patients. Anesth Analg. 2001 Aug; 93(2):301-8, 2nd contents page. Dzankic S, Pastor D, Gonzalez C, Leung JM. PMID: 11473849.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    76. Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans. Anesthesiology. 2000 Oct; 93(4):1004-10. Leung JM, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P. PMID: 11020755.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    77. Predicting adverse postoperative outcomes in patients aged 80 years or older. J Am Geriatr Soc. 2000 Apr; 48(4):405-12. Liu LL, Leung JM. PMID: 10798467.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    78. Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1). Anesthesiology. 2000 Feb; 92(2):407-13. Lieberman JA, Weiskopf RB, Kelley SD, Feiner J, Noorani M, Leung J, Toy P, Viele M. PMID: 10691227.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
    79. Effects of dobutamine on hemodynamics and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients. Anesthesiology. 1999 Nov; 91(5):1318-28. Romson JL, Leung JM, Bellows WH, Bronstein M, Keith F, Moores W, Flachsbart K, Richter R, Pastor D, Fisher DM. PMID: 10551583.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    80. Automated electrocardiograph ST segment trending monitors: accuracy in detecting myocardial ischemia. Anesth Analg. 1998 Jul; 87(1):4-10. Leung JM, Voskanian A, Bellows WH, Pastor D. PMID: 9661536.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    81. Dissociation between haemodynamics and sympathetic activation during anaesthetic induction with desfluranes. Can J Anaesth. 1998 Jun; 45(6):533-40. Leung JM, Pastor DA. PMID: 9669006.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    82. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA. 1998 Jan 21; 279(3):217-21. Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA. PMID: 9438742.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    83. Transesophageal echocardiography in myocardial revascularization: II. Influence on intraoperative decision making. Anesth Analg. 1996 Jun; 82(6):1139-45. Bergquist BD, Bellows WH, Leung JM. PMID: 8638781.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    84. Transesophageal echocardiography in myocardial revascularization: I. Accuracy of intraoperative real-time interpretation. Anesth Analg. 1996 Jun; 82(6):1132-8. Bergquist BD, Leung JM, Bellows WH. PMID: 8638780.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    85. Effects of acadesine on the incidence of myocardial infarction and adverse cardiac outcomes after coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Anesthesiology. 1995 Oct; 83(4):658-73. PMID: 7574044.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    86. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. 1995 Mar; 82(3):620-33. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. PMID: 7879930.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCTClinical Trials
    87. Left ventricular end-systolic cavity obliteration as an estimate of intraoperative hypovolemia. Anesthesiology. 1994 Nov; 81(5):1102-9. Leung JM, Levine EH. PMID: 7978468.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    88. Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization. J Thorac Cardiovasc Surg. 1994 Oct; 108(4):626-35. Hennein HA, Ebba H, Rodriguez JL, Merrick SH, Keith FM, Bronstein MH, Leung JM, Mangano DT, Greenfield LJ, Rankin JS. PMID: 7934095.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    89. Safety and efficacy of intravenous Carbicarb in patients undergoing surgery: comparison with sodium bicarbonate in the treatment of mild metabolic acidosis. SPI Research Group. Study of Perioperative Ischemia. Crit Care Med. 1994 Oct; 22(10):1540-9. Leung JM, Landow L, Franks M, Soja-Strzepa D, Heard SO, Arieff AI, Mangano DT. PMID: 7924363.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    90. An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group. Anesth Analg. 1994 Mar; 78(3):420-34. Leung JM, Stanley T, Mathew J, Curling P, Barash P, Salmenpera M, Reves JG, Hollenberg M, Mangano DT. PMID: 7818622.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    91. Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study. The Study of Perioperative Ischemia (SPI) Research Group. Crit Care Med. 1993 May; 21(5):659-65. Mark NH, Leung JM, Arieff AI, Mangano DT. PMID: 8386997.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    92. Clinical evidence of myocardial stunning in patients undergoing CABG surgery. J Card Surg. 1993 Mar; 8(2 Suppl):220-3. Leung JM. PMID: 8461506.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    93. Effects of steal-prone anatomy on intraoperative myocardial ischemia. The SPI Research Group. J Am Coll Cardiol. 1992 Nov 01; 20(5):1205-12. Leung JM, Hollenberg M, O'Kelly BF, Kao A, Mangano DT. PMID: 1401623.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    94. Monitoring for myocardial ischemia during noncardiac surgery. A technology assessment of transesophageal echocardiography and 12-lead electrocardiography. The Study of Perioperative Ischemia Research Group. JAMA. 1992 Jul 08; 268(2):210-6. Eisenberg MJ, London MJ, Leung JM, Browner WS, Hollenberg M, Tubau JF, Tateo IM, Schiller NB, Mangano DT. PMID: 1608139.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    95. The risk of myocardial ischemia in patients receiving desflurane versus sufentanil anesthesia for coronary artery bypass graft surgery. The S.P.I. Research Group. Anesthesiology. 1992 Jul; 77(1):47-62. Helman JD, Leung JM, Bellows WH, Pineda N, Roach GW, Reeves JD, Howse J, McEnany MT, Mangano DT. PMID: 1535185.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    96. Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. The Study of Perioperative Ischemia (SPI) Research Group. Anesthesiology. 1992 Mar; 76(3):342-53. Mangano DT, Siliciano D, Hollenberg M, Leung JM, Browner WS, Goehner P, Merrick S, Verrier E. PMID: 1531742.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCTClinical Trials
    97. Ventricular dysrhythmias in patients undergoing coronary artery bypass graft surgery: incidence, characteristics, and prognostic importance. Study of Perioperative Ischemia (SPI) Research Group. Am Heart J. 1992 Jan; 123(1):73-81. Smith RC, Leung JM, Keith FM, Merrick S, Mangano DT. PMID: 1370363.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    98. The role of hemodynamics in perioperative myocardial ischemia. Int Anesthesiol Clin. 1992; 30(1):63-79. Leung JM. PMID: 1577543.
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    99. Isoflurane anesthesia and myocardial ischemia: comparative risk versus sufentanil anesthesia in patients undergoing coronary artery bypass graft surgery. The SPI (Study of Perioperative Ischemia) Research Group. Anesthesiology. 1991 May; 74(5):838-47. Leung JM, Goehner P, O'Kelly BF, Hollenberg M, Pineda N, Cason BA, Mangano DT. PMID: 1826989.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    100. Postoperative myocardial ischemia in patients undergoing coronary artery bypass graft surgery. S.P.I. Research Group. Anesthesiology. 1991 Mar; 74(3):464-73. Smith RC, Leung JM, Mangano DT. PMID: 2001026.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    101. Relationship of regional wall motion abnormalities to hemodynamic indices of myocardial oxygen supply and demand in patients undergoing CABG surgery. Anesthesiology. 1990 Nov; 73(5):802-14. Leung JM, O'Kelly BF, Mangano DT. PMID: 2240670.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    102. Prognostic importance of postbypass regional wall-motion abnormalities in patients undergoing coronary artery bypass graft surgery. SPI Research Group. Anesthesiology. 1989 Jul; 71(1):16-25. Leung JM, O'Kelly B, Browner WS, Tubau J, Hollenberg M, Mangano DT. PMID: 2787609.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    103. Transesophageal echocardiographic assessment of left ventricular function. Int J Card Imaging. 1989; 5(1):63-70. Leung JM, Schiller NB, Mangano DT. PMID: 2693536.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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