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Jacqueline Leung, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address500 Parnassus Avenue
San Francisco CA 94117
Phone415-476-0711
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Clinical Fellowship Cardiology
    University of California, San FranciscoResidency
    Stanford UniversityM.D.1984School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Leung is the director of the Perioperative Medicine Research Group based at UCSF Medical Center. The group conducts outcomes research in older surgical patients. Our recent work focuses on identifying the pathophysiology of postoperative delirium and cognitive decline, and also the mechanism between sleep disruption and ICU delirium.


    Collapse Research 
    Collapse Research Activities and Funding
    The Effects of Light vs Deep Anesthesia on Postoperative Cognitive Outcomes
    NIH/NIA R21AG048456Jun 1, 2015 - May 31, 2017
    Role: Principal Investigator
    Pathophysiology of postoperative delirium in older patients
    NIH/NIA R01AG031795Sep 15, 2009 - Aug 31, 2014
    Role: Principal Investigator
    AGING AND PERIOPERATIVE OUTCOMES
    NIH/NIA K24AG000948Mar 1, 2001 - Feb 28, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Faculty Mentoring
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung J. Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. J Neuroinflammation. 2016; 13(1):211. PMID: 27577265.
      View in: PubMed
    2. Hirsch J, Leung J. Reply: heterogeneous population. Br J Anaesth. 2016 Aug; 117(2):262. PMID: 27440643.
      View in: PubMed
    3. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung J. The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Anesth Analg. 2016 Jul; 123(1):206-12. PMID: 27159066.
      View in: PubMed
    4. Leung J, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K. Preoperative Sleep Disruption and Postoperative Delirium. J Clin Sleep Med. 2015 Aug; 11(8):907-13. PMID: 25979094; PMCID: PMC4513268 [Available on 02/15/16].
      View in: PubMed, PubMed Central
    5. Shim J, DePalma G, Sands LP, Leung J. Prognostic Significance of Postoperative Subsyndromal Delirium. Psychosomatics. 2015 Nov-Dec; 56(6):644-51. PMID: 26198571.
      View in: PubMed
    6. Hirsch J, DePalma G, Tsai TT, Sands LP, Leung J. Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Br J Anaesth. 2015 Sep; 115(3):418-26. PMID: 25616677; PMCID: PMC4533731 [Available on 09/01/16].
      View in: PubMed, PubMed Central
    7. Long LS, Wolpaw JT, Leung J. Sensitivity and specificity of the animal fluency test for predicting postoperative delirium. Can J Anaesth. 2015 Jun; 62(6):603-8. PMID: 25537737.
      View in: PubMed
    8. Youngblom E, DePalma G, Sands L, Leung J. The temporal relationship between early postoperative delirium and postoperative cognitive dysfunction in older patients: a prospective cohort study. Can J Anaesth. 2014 Dec; 61(12):1084-92. PMID: 25287962.
      View in: PubMed
    9. Leung J, Sands LP, Lim E, Tsai TL, Kinjo S. Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium? Am J Geriatr Psychiatry. 2013 Oct; 21(10):946-56. PMID: 23659900; PMCID: PMC3742555.
      View in: PubMed, PubMed Central
    10. Behrends M, DePalma G, Sands L, Leung J. Association between intraoperative blood transfusions and early postoperative delirium in older adults. J Am Geriatr Soc. 2013 Mar; 61(3):365-70. PMID: 23496244; PMCID: PMC4529289.
      View in: PubMed, PubMed Central
    11. DeCrane SK, Sands LP, Young KM, DePalma G, Leung J. Impact of missing data on analysis of postoperative cognitive decline (POCD). Appl Nurs Res. 2013 May; 26(2):71-5. PMID: 23290047; PMCID: PMC3620895.
      View in: PubMed, PubMed Central
    12. Shim JJ, Leung J. An update on delirium in the postoperative setting: prevention, diagnosis and management. Best Pract Res Clin Anaesthesiol. 2012 Sep; 26(3):327-43. PMID: 23040284.
      View in: PubMed
    13. Long LS, Shapiro WA, Leung J. A brief review of practical preoperative cognitive screening tools. Can J Anaesth. 2012 Aug; 59(8):798-804. PMID: 22638676; PMCID: PMC3711831.
      View in: PubMed, PubMed Central
    14. Kinjo S, Lim E, Sands LP, Bozic KJ, Leung J. Does using a femoral nerve block for total knee replacement decrease postoperative delirium? BMC Anesthesiol. 2012; 12:4. PMID: 22405052; PMCID: PMC3364862.
      View in: PubMed, PubMed Central
    15. Kinjo S, Sands LP, Lim E, Paul S, Leung J. Prediction of postoperative pain using path analysis in older patients. J Anesth. 2012 Feb; 26(1):1-8. PMID: 22012171; PMCID: PMC3720127.
      View in: PubMed, PubMed Central
    16. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung J, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M. Perioperative cognitive decline in the aging population. Mayo Clin Proc. 2011 Sep; 86(9):885-93. PMID: 21878601; PMCID: PMC3257991.
      View in: PubMed, PubMed Central
    17. DeCrane SK, Sands L, Ashland M, Lim E, Tsai TL, Paul S, Leung J. Factors associated with recovery from early postoperative delirium. J Perianesth Nurs. 2011 Aug; 26(4):231-41. PMID: 21803271; PMCID: PMC3148485.
      View in: PubMed, PubMed Central
    18. Leung J, Tsai TL, Sands LP. Brief report: preoperative frailty in older surgical patients is associated with early postoperative delirium. Anesth Analg. 2011 May; 112(5):1199-201. PMID: 21372278; PMCID: PMC3081949.
      View in: PubMed, PubMed Central
    19. Leung J. Postoperative delirium: are there modifiable risk factors? Eur J Anaesthesiol. 2010 May; 27(5):403-5. PMID: 20386385.
      View in: PubMed
    20. Tsai TL, Sands LP, Leung J. An Update on Postoperative Cognitive Dysfunction. Adv Anesth. 2010; 28(1):269-284. PMID: 21151735.
      View in: PubMed
    21. Leung J, Sands LP. Long-term cognitive decline: is there a link to surgery and anesthesia? Anesthesiology. 2009 Nov; 111(5):931-2. PMID: 19786857.
      View in: PubMed
    22. Leung J, Sands LP, Paul S, Joseph T, Kinjo S, Tsai T. Does postoperative delirium limit the use of patient-controlled analgesia in older surgical patients? Anesthesiology. 2009 Sep; 111(3):625-31. PMID: 19672166; PMCID: PMC2762324.
      View in: PubMed, PubMed Central
    23. Leung J, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR. Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology. 2007 Sep; 107(3):406-11. PMID: 17721242.
      View in: PubMed
    24. Wang Y, Sands LP, Vaurio L, Mullen EA, Leung J. The effects of postoperative pain and its management on postoperative cognitive dysfunction. Am J Geriatr Psychiatry. 2007 Jan; 15(1):50-9. PMID: 17194815.
      View in: PubMed
    25. Nakai T, Chandy J, Nakai K, Bellows WH, Flachsbart K, Lee RJ, Leung J. Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery. Cardiology. 2007; 108(2):90-6. PMID: 17008797.
      View in: PubMed
    26. Leung J, Sands LP, Rico M, Petersen KL, Rowbotham MC, Dahl JB, Ames C, Chou D, Weinstein P. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology. 2006 Oct 10; 67(7):1251-3. PMID: 16914695.
      View in: PubMed
    27. Leung J, Sands LP, Vaurio LE, Wang Y. Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients. Br J Anaesth. 2006 Jun; 96(6):754-60. PMID: 16670110.
      View in: PubMed
    28. Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung J. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006 Apr; 102(4):1267-73. PMID: 16551935.
      View in: PubMed
    29. Fong HK, Sands LP, Leung J. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg. 2006 Apr; 102(4):1255-66. PMID: 16551934.
      View in: PubMed
    30. Leung J, Sands LP, Mullen EA, Wang Y, Vaurio L. Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients? J Gerontol A Biol Sci Med Sci. 2005 Dec; 60(12):1563-8. PMID: 16424289.
      View in: PubMed
    31. Leung J, Bellows WH, Schiller NB. Impairment of left atrial function predicts post-operative atrial fibrillation after coronary artery bypass graft surgery. Eur Heart J. 2004 Oct; 25(20):1836-44. PMID: 15474699.
      View in: PubMed
    32. Leung J, Bellows WH, Pastor D. Does intraoperative evaluation of left ventricular contractile reserve predict myocardial viability? A clinical study using dobutamine stress echocardiography in patients undergoing coronary artery bypass graft surgery. Anesth Analg. 2004 Sep; 99(3):647-54, table of contents. PMID: 15333387.
      View in: PubMed
    33. Chandy J, Nakai T, Lee RJ, Bellows WH, Dzankic S, Leung J. Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery. Anesth Analg. 2004 Feb; 98(2):303-10, table of contents. PMID: 14742359.
      View in: PubMed
    34. Phillip B, Pastor D, Bellows W, Leung J. The prevalence of preoperative diastolic filling abnormalities in geriatric surgical patients. Anesth Analg. 2003 Nov; 97(5):1214-21. PMID: 14570626.
      View in: PubMed
    35. Manku K, Leung J. Prognostic significance of postoperative in-hospital complications in elderly patients. II. Long-term quality of life. Anesth Analg. 2003 Feb; 96(2):590-4, table of contents. PMID: 12538217.
      View in: PubMed
    36. Manku K, Bacchetti P, Leung J. Prognostic significance of postoperative in-hospital complications in elderly patients. I. Long-term survival. Anesth Analg. 2003 Feb; 96(2):583-9, table of contents. PMID: 12538216.
      View in: PubMed
    37. Bacchetti P, Leung J. Sample size calculations in clinical research. Anesthesiology. 2002 Oct; 97(4):1028-9; author reply 1029-32. PMID: 12357184.
      View in: PubMed
    38. Liu LL, Dzankic S, Leung J. Preoperative electrocardiogram abnormalities do not predict postoperative cardiac complications in geriatric surgical patients. J Am Geriatr Soc. 2002 Jul; 50(7):1186-91. PMID: 12133011.
      View in: PubMed
    39. Block M, Hourigan L, Bellows WH, Reeves J, Romson JL, Tran M, Pastor D, Schiller NB, Leung J. Comparison of left atrial dimensions by transesophageal and transthoracic echocardiography. J Am Soc Echocardiogr. 2002 Feb; 15(2):143-9. PMID: 11836489.
      View in: PubMed
    40. Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J, Romson J, Ferguson S, Leung J. The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery. Am Heart J. 2002 Jan; 143(1):181-6. PMID: 11773931.
      View in: PubMed
    41. Leung J, Dzankic S, Manku K, Yuan S. The prevalence and predictors of the use of alternative medicine in presurgical patients in five California hospitals. Anesth Analg. 2001 Oct; 93(4):1062-8. PMID: 11574384.
      View in: PubMed
    42. Leung J, Dzankic S. Relative importance of preoperative health status versus intraoperative factors in predicting postoperative adverse outcomes in geriatric surgical patients. J Am Geriatr Soc. 2001 Aug; 49(8):1080-5. PMID: 11555070.
      View in: PubMed
    43. Dzankic S, Pastor D, Gonzalez C, Leung J. The prevalence and predictive value of abnormal preoperative laboratory tests in elderly surgical patients. Anesth Analg. 2001 Aug; 93(2):301-8, 2nd contents page. PMID: 11473849.
      View in: PubMed
    44. Leung J, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P. Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans. Anesthesiology. 2000 Oct; 93(4):1004-10. PMID: 11020755.
      View in: PubMed
    45. Liu LL, Leung J. Predicting adverse postoperative outcomes in patients aged 80 years or older. J Am Geriatr Soc. 2000 Apr; 48(4):405-12. PMID: 10798467.
      View in: PubMed
    46. Romson JL, Leung J, Bellows WH, Bronstein M, Keith F, Moores W, Flachsbart K, Richter R, Pastor D, Fisher DM. Effects of dobutamine on hemodynamics and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients. Anesthesiology. 1999 Nov; 91(5):1318-28. PMID: 10551583.
      View in: PubMed
    47. Leung J, Voskanian A, Bellows WH, Pastor D. Automated electrocardiograph ST segment trending monitors: accuracy in detecting myocardial ischemia. Anesth Analg. 1998 Jul; 87(1):4-10. PMID: 9661536.
      View in: PubMed
    48. Leung J, Pastor DA. Dissociation between haemodynamics and sympathetic activation during anaesthetic induction with desfluranes. Can J Anaesth. 1998 Jun; 45(6):533-40. PMID: 9669006.
      View in: PubMed
    49. Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung J, Fisher DM, Murray WR, Toy P, Moore MA. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA. 1998 Jan 21; 279(3):217-21. PMID: 9438742.
      View in: PubMed
    50. Bergquist BD, Leung J, Bellows WH. Transesophageal echocardiography in myocardial revascularization: I. Accuracy of intraoperative real-time interpretation. Anesth Analg. 1996 Jun; 82(6):1132-8. PMID: 8638780.
      View in: PubMed
    51. Bergquist BD, Bellows WH, Leung J. Transesophageal echocardiography in myocardial revascularization: II. Influence on intraoperative decision making. Anesth Analg. 1996 Jun; 82(6):1139-45. PMID: 8638781.
      View in: PubMed
    52. Leung J. Role of epidural anesthesia and analgesia on postoperative patient outcome. Anesthesiology. 1995 Nov; 83(5):1132. PMID: 7486171.
      View in: PubMed
    53. Leung J, Levine EH. Left ventricular end-systolic cavity obliteration as an estimate of intraoperative hypovolemia. Anesthesiology. 1994 Nov; 81(5):1102-9. PMID: 7978468.
      View in: PubMed
    54. Leung J, Stanley T, Mathew J, Curling P, Barash P, Salmenpera M, Reves JG, Hollenberg M, Mangano DT. An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group. Anesth Analg. 1994 Mar; 78(3):420-34. PMID: 7818622.
      View in: PubMed
    55. Leung J. Clinical evidence of myocardial stunning in patients undergoing CABG surgery. J Card Surg. 1993 Mar; 8(2 Suppl):220-3. PMID: 8461506.
      View in: PubMed
    56. Bergquist BD, Leung J. Perioperative monitoring of myocardial ischemia. Int Anesthesiol Clin. 1993; 31(3):23-44. PMID: 8375909.
      View in: PubMed
    57. Eisenberg MJ, London MJ, Leung J, Browner WS, Hollenberg M, Tubau JF, Tateo IM, Schiller NB, Mangano DT. Monitoring for myocardial ischemia during noncardiac surgery. A technology assessment of transesophageal echocardiography and 12-lead electrocardiography. The Study of Perioperative Ischemia Research Group. JAMA. 1992 Jul 8; 268(2):210-6. PMID: 1608139.
      View in: PubMed
    58. Helman JD, Leung J, Bellows WH, Pineda N, Roach GW, Reeves JD, Howse J, McEnany MT, Mangano DT. The risk of myocardial ischemia in patients receiving desflurane versus sufentanil anesthesia for coronary artery bypass graft surgery. The S.P.I. Research Group. Anesthesiology. 1992 Jul; 77(1):47-62. PMID: 1535185.
      View in: PubMed
    59. Mangano DT, Siliciano D, Hollenberg M, Leung J, Browner WS, Goehner P, Merrick S, Verrier E. Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. The Study of Perioperative Ischemia (SPI) Research Group. Anesthesiology. 1992 Mar; 76(3):342-53. PMID: 1531742.
      View in: PubMed
    60. Smith RC, Leung J, Keith FM, Merrick S, Mangano DT. Ventricular dysrhythmias in patients undergoing coronary artery bypass graft surgery: incidence, characteristics, and prognostic importance. Study of Perioperative Ischemia (SPI) Research Group. Am Heart J. 1992 Jan; 123(1):73-81. PMID: 1370363.
      View in: PubMed
    61. Leung J, Goehner P, O'Kelly BF, Hollenberg M, Pineda N, Cason BA, Mangano DT. Isoflurane anesthesia and myocardial ischemia: comparative risk versus sufentanil anesthesia in patients undergoing coronary artery bypass graft surgery. The SPI (Study of Perioperative Ischemia) Research Group. Anesthesiology. 1991 May; 74(5):838-47. PMID: 1826989.
      View in: PubMed
    62. Smith RC, Leung J, Mangano DT. Postoperative myocardial ischemia in patients undergoing coronary artery bypass graft surgery. S.P.I. Research Group. Anesthesiology. 1991 Mar; 74(3):464-73. PMID: 2001026.
      View in: PubMed
    63. Leung J, O'Kelly BF, Mangano DT. Relationship of regional wall motion abnormalities to hemodynamic indices of myocardial oxygen supply and demand in patients undergoing CABG surgery. Anesthesiology. 1990 Nov; 73(5):802-14. PMID: 2240670.
      View in: PubMed
    64. Leung J, O'Kelly B, Browner WS, Tubau J, Hollenberg M, Mangano DT. Prognostic importance of postbypass regional wall-motion abnormalities in patients undergoing coronary artery bypass graft surgery. SPI Research Group. Anesthesiology. 1989 Jul; 71(1):16-25. PMID: 2787609.
      View in: PubMed
    65. Leung J, Schiller NB, Mangano DT. Transesophageal echocardiographic assessment of left ventricular function. Int J Card Imaging. 1989; 5(1):63-70. PMID: 2693536.
      View in: PubMed
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