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Jacqueline Leung, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address500 Parnassus Avenue
San Francisco CA 94117
Phone415-476-0711
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Clinical Fellowship Cardiology
    University of California, San FranciscoResidency
    Stanford UniversityM.D.1984School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Leung is the director of the Perioperative Medicine Research Group based at UCSF Medical Center. The group conducts outcomes research in older surgical patients. Our recent work focuses on identifying the pathophysiology of postoperative delirium and cognitive decline, and also the mechanism between sleep disruption and ICU delirium.


    Collapse Research 
    Collapse Research Activities and Funding
    Acute preoperative sleep disruption and postoperative delirium
    NIH/NIA R21AG053715Mar 1, 2017 - Feb 28, 2019
    Role: Principal Investigator
    The Effects of Light vs Deep Anesthesia on Postoperative Cognitive Outcomes
    NIH/NIA R21AG048456Jun 1, 2015 - May 31, 2017
    Role: Principal Investigator
    Pathophysiology of postoperative delirium in older patients
    NIH/NIA R01AG031795Sep 15, 2009 - Aug 31, 2014
    Role: Principal Investigator
    AGING AND PERIOPERATIVE OUTCOMES
    NIH/NIA K24AG000948Mar 1, 2001 - Feb 28, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Faculty Mentoring
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Leung J, Budischak SA, Chung The H, Hansen C, Bowcutt R, Neill R, Shellman M, Loke P, Graham AL. Rapid environmental effects on gut nematode susceptibility in rewilded mice. PLoS Biol. 2018 Mar; 16(3):e2004108. PMID: 29518091.
      View in: PubMed
    2. Leung J, Sands LP, Chen N, Ames C, Berven S, Bozic K, Burch S, Chou D, Covinsky K, Deviren V, Kinjo S, Kramer JH, Ries M, Tay B, Vail T, Weinstein P, Chang S, Meckler G, Newman S, Tsai T, Voss V, Youngblom E. Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. Anesthesiology. 2017 10; 127(4):633-644. PMID: 28727581.
      View in: PubMed
    3. Tang MS, Bowcutt R, Leung J, Wolff MJ, Gundra UM, Hudesman D, Malter LB, Poles MA, Chen LA, Pei Z, Neto AG, Abidi WM, Ullman T, Mayer L, Bonneau RA, Cho I, Loke P. Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells. Inflamm Bowel Dis. 2017 Sep; 23(9):1544-1554. PMID: 28806280.
      View in: PubMed
    4. Hargrave A, Bastiaens J, Bourgeois JA, Neuhaus J, Josephson SA, Chinn J, Lee M, Leung J, Douglas V. Validation of a Nurse-Based Delirium-Screening Tool for Hospitalized Patients. Psychosomatics. 2017 Nov - Dec; 58(6):594-603. PMID: 28750835.
      View in: PubMed
    5. Gras S, Jackson A, Woods S, Pall G, Whitelaw J, Leung J, Ward GE, Roberts CW, Meissner M. Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo. Wellcome Open Res. 2017; 2:32. PMID: 28630943.
      View in: PubMed
    6. Muhlhofer WG, Zak R, Kamal T, Rizvi B, Sands LP, Yuan M, Zhang X, Leung J. Burst-suppression ratio underestimates absolute duration of electroencephalogram suppression compared with visual analysis of intraoperative electroencephalogram. Br J Anaesth. 2017 May 01; 118(5):755-761. PMID: 28486575.
      View in: PubMed
    7. Leung J, He Y, Zhang F, Hwang YC, Nagayasu E, Liu J, Murray JM, Hu K. Stability and function of a putative microtubule-organizing center in the human parasite Toxoplasma gondii. Mol Biol Cell. 2017 May 15; 28(10):1361-1378. PMID: 28331073.
      View in: PubMed
    8. Whitelaw JA, Latorre-Barragan F, Gras S, Pall GS, Leung J, Heaslip A, Egarter S, Andenmatten N, Nelson SR, Warshaw DM, Ward GE, Meissner M. Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion. BMC Biol. 2017 01 18; 15(1):1. PMID: 28100223.
      View in: PubMed
    9. Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung J. Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. J Neuroinflammation. 2016 08 30; 13(1):211. PMID: 27577265.
      View in: PubMed
    10. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung J. The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Anesth Analg. 2016 07; 123(1):206-12. PMID: 27159066.
      View in: PubMed
    11. Wildes TS, Winter AC, Maybrier HR, Mickle AM, Lenze EJ, Stark S, Lin N, Inouye SK, Schmitt EM, McKinnon SL, Muench MR, Murphy MR, Upadhyayula RT, Fritz BA, Escallier KE, Apakama GP, Emmert DA, Graetz TJ, Stevens TW, Palanca BJ, Hueneke R, Melby S, Torres B, Leung J, Jacobsohn E, Avidan MS. Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study: a pragmatic, randomised clinical trial. BMJ Open. 2016 06 15; 6(6):e011505. PMID: 27311914.
      View in: PubMed
    12. Leung J, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K. Preoperative Sleep Disruption and Postoperative Delirium. J Clin Sleep Med. 2015 Aug 15; 11(8):907-13. PMID: 25979094; PMCID: PMC4513268.
      View in: PubMed, PubMed Central
    13. Shim J, DePalma G, Sands LP, Leung J. Prognostic Significance of Postoperative Subsyndromal Delirium. Psychosomatics. 2015 Nov-Dec; 56(6):644-51. PMID: 26198571.
      View in: PubMed
    14. Long LS, Wolpaw JT, Leung J. Sensitivity and specificity of the animal fluency test for predicting postoperative delirium. Can J Anaesth. 2015 Jun; 62(6):603-8. PMID: 25537737.
      View in: PubMed
    15. Youngblom E, DePalma G, Sands L, Leung J. The temporal relationship between early postoperative delirium and postoperative cognitive dysfunction in older patients: a prospective cohort study. Can J Anaesth. 2014 Dec; 61(12):1084-92. PMID: 25287962.
      View in: PubMed
    16. Leung J, Sands LP, Lim E, Tsai TL, Kinjo S. Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium? Am J Geriatr Psychiatry. 2013 Oct; 21(10):946-56. PMID: 23659900; PMCID: PMC3742555.
      View in: PubMed, PubMed Central
    17. Behrends M, DePalma G, Sands L, Leung J. Association between intraoperative blood transfusions and early postoperative delirium in older adults. J Am Geriatr Soc. 2013 Mar; 61(3):365-70. PMID: 23496244; PMCID: PMC4529289.
      View in: PubMed, PubMed Central
    18. Shim JJ, Leung J. An update on delirium in the postoperative setting: prevention, diagnosis and management. Best Pract Res Clin Anaesthesiol. 2012 Sep; 26(3):327-43. PMID: 23040284.
      View in: PubMed
    19. Long LS, Shapiro WA, Leung J. A brief review of practical preoperative cognitive screening tools. Can J Anaesth. 2012 Aug; 59(8):798-804. PMID: 22638676; PMCID: PMC3711831.
      View in: PubMed, PubMed Central
    20. Kinjo S, Lim E, Sands LP, Bozic KJ, Leung J. Does using a femoral nerve block for total knee replacement decrease postoperative delirium? BMC Anesthesiol. 2012 Mar 10; 12:4. PMID: 22405052; PMCID: PMC3364862.
      View in: PubMed, PubMed Central
    21. Kinjo S, Sands LP, Lim E, Paul S, Leung J. Prediction of postoperative pain using path analysis in older patients. J Anesth. 2012 Feb; 26(1):1-8. PMID: 22012171; PMCID: PMC3720127.
      View in: PubMed, PubMed Central
    22. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung J, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M. Perioperative cognitive decline in the aging population. Mayo Clin Proc. 2011 Sep; 86(9):885-93. PMID: 21878601; PMCID: PMC3257991.
      View in: PubMed, PubMed Central
    23. DeCrane SK, Sands L, Ashland M, Lim E, Tsai TL, Paul S, Leung J. Factors associated with recovery from early postoperative delirium. J Perianesth Nurs. 2011 Aug; 26(4):231-41. PMID: 21803271; PMCID: PMC3148485.
      View in: PubMed, PubMed Central
    24. Leung J, Tsai TL, Sands LP. Brief report: preoperative frailty in older surgical patients is associated with early postoperative delirium. Anesth Analg. 2011 May; 112(5):1199-201. PMID: 21372278; PMCID: PMC3081949.
      View in: PubMed, PubMed Central
    25. Leung J. Postoperative delirium: are there modifiable risk factors? Eur J Anaesthesiol. 2010 May; 27(5):403-5. PMID: 20386385.
      View in: PubMed
    26. Tsai TL, Sands LP, Leung J. An Update on Postoperative Cognitive Dysfunction. Adv Anesth. 2010; 28(1):269-284. PMID: 21151735.
      View in: PubMed
    27. Leung J, Sands LP. Long-term cognitive decline: is there a link to surgery and anesthesia? Anesthesiology. 2009 Nov; 111(5):931-2. PMID: 19786857.
      View in: PubMed
    28. Leung J, Sands LP, Paul S, Joseph T, Kinjo S, Tsai T. Does postoperative delirium limit the use of patient-controlled analgesia in older surgical patients? Anesthesiology. 2009 Sep; 111(3):625-31. PMID: 19672166; PMCID: PMC2762324.
      View in: PubMed, PubMed Central
    29. Leung J, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR. Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology. 2007 Sep; 107(3):406-11. PMID: 17721242.
      View in: PubMed
    30. Wang Y, Sands LP, Vaurio L, Mullen EA, Leung J. The effects of postoperative pain and its management on postoperative cognitive dysfunction. Am J Geriatr Psychiatry. 2007 Jan; 15(1):50-9. PMID: 17194815.
      View in: PubMed
    31. Nakai T, Chandy J, Nakai K, Bellows WH, Flachsbart K, Lee RJ, Leung J. Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery. Cardiology. 2007; 108(2):90-6. PMID: 17008797.
      View in: PubMed
    32. Leung J, Sands LP, Rico M, Petersen KL, Rowbotham MC, Dahl JB, Ames C, Chou D, Weinstein P. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology. 2006 Oct 10; 67(7):1251-3. PMID: 16914695.
      View in: PubMed
    33. Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung J. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006 Apr; 102(4):1267-73. PMID: 16551935.
      View in: PubMed
    34. Fong HK, Sands LP, Leung J. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg. 2006 Apr; 102(4):1255-66. PMID: 16551934.
      View in: PubMed
    35. Leung J, Sands LP, Mullen EA, Wang Y, Vaurio L. Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients? J Gerontol A Biol Sci Med Sci. 2005 Dec; 60(12):1563-8. PMID: 16424289.
      View in: PubMed
    36. Leung J, Bellows WH, Schiller NB. Impairment of left atrial function predicts post-operative atrial fibrillation after coronary artery bypass graft surgery. Eur Heart J. 2004 Oct; 25(20):1836-44. PMID: 15474699.
      View in: PubMed
    37. Leung J, Bellows WH, Pastor D. Does intraoperative evaluation of left ventricular contractile reserve predict myocardial viability? A clinical study using dobutamine stress echocardiography in patients undergoing coronary artery bypass graft surgery. Anesth Analg. 2004 Sep; 99(3):647-54, table of contents. PMID: 15333387.
      View in: PubMed
    38. Chandy J, Nakai T, Lee RJ, Bellows WH, Dzankic S, Leung J. Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery. Anesth Analg. 2004 Feb; 98(2):303-10, table of contents. PMID: 14742359.
      View in: PubMed
    39. Phillip B, Pastor D, Bellows W, Leung J. The prevalence of preoperative diastolic filling abnormalities in geriatric surgical patients. Anesth Analg. 2003 Nov; 97(5):1214-21. PMID: 14570626.
      View in: PubMed
    40. Manku K, Leung J. Prognostic significance of postoperative in-hospital complications in elderly patients. II. Long-term quality of life. Anesth Analg. 2003 Feb; 96(2):590-4, table of contents. PMID: 12538217.
      View in: PubMed
    41. Manku K, Bacchetti P, Leung J. Prognostic significance of postoperative in-hospital complications in elderly patients. I. Long-term survival. Anesth Analg. 2003 Feb; 96(2):583-9, table of contents. PMID: 12538216.
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    42. Bacchetti P, Leung J. Sample size calculations in clinical research. Anesthesiology. 2002 Oct; 97(4):1028-9; author reply 1029-32. PMID: 12357184.
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    43. Liu LL, Dzankic S, Leung J. Preoperative electrocardiogram abnormalities do not predict postoperative cardiac complications in geriatric surgical patients. J Am Geriatr Soc. 2002 Jul; 50(7):1186-91. PMID: 12133011.
      View in: PubMed
    44. Block M, Hourigan L, Bellows WH, Reeves J, Romson JL, Tran M, Pastor D, Schiller NB, Leung J. Comparison of left atrial dimensions by transesophageal and transthoracic echocardiography. J Am Soc Echocardiogr. 2002 Feb; 15(2):143-9. PMID: 11836489.
      View in: PubMed
    45. Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J, Romson J, Ferguson S, Leung J. The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery. Am Heart J. 2002 Jan; 143(1):181-6. PMID: 11773931.
      View in: PubMed
    46. Leung J, Dzankic S, Manku K, Yuan S. The prevalence and predictors of the use of alternative medicine in presurgical patients in five California hospitals. Anesth Analg. 2001 Oct; 93(4):1062-8. PMID: 11574384.
      View in: PubMed
    47. Leung J, Dzankic S. Relative importance of preoperative health status versus intraoperative factors in predicting postoperative adverse outcomes in geriatric surgical patients. J Am Geriatr Soc. 2001 Aug; 49(8):1080-5. PMID: 11555070.
      View in: PubMed
    48. Dzankic S, Pastor D, Gonzalez C, Leung J. The prevalence and predictive value of abnormal preoperative laboratory tests in elderly surgical patients. Anesth Analg. 2001 Aug; 93(2):301-8, 2nd contents page. PMID: 11473849.
      View in: PubMed
    49. Leung J, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P. Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans. Anesthesiology. 2000 Oct; 93(4):1004-10. PMID: 11020755.
      View in: PubMed
    50. Liu LL, Leung J. Predicting adverse postoperative outcomes in patients aged 80 years or older. J Am Geriatr Soc. 2000 Apr; 48(4):405-12. PMID: 10798467.
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    51. Romson JL, Leung J, Bellows WH, Bronstein M, Keith F, Moores W, Flachsbart K, Richter R, Pastor D, Fisher DM. Effects of dobutamine on hemodynamics and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients. Anesthesiology. 1999 Nov; 91(5):1318-28. PMID: 10551583.
      View in: PubMed
    52. Leung J, Voskanian A, Bellows WH, Pastor D. Automated electrocardiograph ST segment trending monitors: accuracy in detecting myocardial ischemia. Anesth Analg. 1998 Jul; 87(1):4-10. PMID: 9661536.
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    53. Leung J, Pastor DA. Dissociation between haemodynamics and sympathetic activation during anaesthetic induction with desfluranes. Can J Anaesth. 1998 Jun; 45(6):533-40. PMID: 9669006.
      View in: PubMed
    54. Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung J, Fisher DM, Murray WR, Toy P, Moore MA. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA. 1998 Jan 21; 279(3):217-21. PMID: 9438742.
      View in: PubMed
    55. Bergquist BD, Leung J, Bellows WH. Transesophageal echocardiography in myocardial revascularization: I. Accuracy of intraoperative real-time interpretation. Anesth Analg. 1996 Jun; 82(6):1132-8. PMID: 8638780.
      View in: PubMed
    56. Bergquist BD, Bellows WH, Leung J. Transesophageal echocardiography in myocardial revascularization: II. Influence on intraoperative decision making. Anesth Analg. 1996 Jun; 82(6):1139-45. PMID: 8638781.
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    57. Leung J. Role of epidural anesthesia and analgesia on postoperative patient outcome. Anesthesiology. 1995 Nov; 83(5):1132. PMID: 7486171.
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    58. Leung J, Levine EH. Left ventricular end-systolic cavity obliteration as an estimate of intraoperative hypovolemia. Anesthesiology. 1994 Nov; 81(5):1102-9. PMID: 7978468.
      View in: PubMed
    59. Hennein HA, Ebba H, Rodriguez JL, Merrick SH, Keith FM, Bronstein MH, Leung J, Mangano DT, Greenfield LJ, Rankin JS. Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization. J Thorac Cardiovasc Surg. 1994 Oct; 108(4):626-35. PMID: 7934095.
      View in: PubMed
    60. Leung J, Stanley T, Mathew J, Curling P, Barash P, Salmenpera M, Reves JG, Hollenberg M, Mangano DT. An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group. Anesth Analg. 1994 Mar; 78(3):420-34. PMID: 7818622.
      View in: PubMed
    61. Mark NH, Leung J, Arieff AI, Mangano DT. Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study. The Study of Perioperative Ischemia (SPI) Research Group. Crit Care Med. 1993 May; 21(5):659-65. PMID: 8386997.
      View in: PubMed
    62. Leung J. Clinical evidence of myocardial stunning in patients undergoing CABG surgery. J Card Surg. 1993 Mar; 8(2 Suppl):220-3. PMID: 8461506.
      View in: PubMed
    63. Bergquist BD, Leung J. Perioperative monitoring of myocardial ischemia. Int Anesthesiol Clin. 1993; 31(3):23-44. PMID: 8375909.
      View in: PubMed
    64. Eisenberg MJ, London MJ, Leung J, Browner WS, Hollenberg M, Tubau JF, Tateo IM, Schiller NB, Mangano DT. Monitoring for myocardial ischemia during noncardiac surgery. A technology assessment of transesophageal echocardiography and 12-lead electrocardiography. The Study of Perioperative Ischemia Research Group. JAMA. 1992 Jul 08; 268(2):210-6. PMID: 1608139.
      View in: PubMed
    65. Helman JD, Leung J, Bellows WH, Pineda N, Roach GW, Reeves JD, Howse J, McEnany MT, Mangano DT. The risk of myocardial ischemia in patients receiving desflurane versus sufentanil anesthesia for coronary artery bypass graft surgery. The S.P.I. Research Group. Anesthesiology. 1992 Jul; 77(1):47-62. PMID: 1535185.
      View in: PubMed
    66. Mangano DT, Siliciano D, Hollenberg M, Leung J, Browner WS, Goehner P, Merrick S, Verrier E. Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. The Study of Perioperative Ischemia (SPI) Research Group. Anesthesiology. 1992 Mar; 76(3):342-53. PMID: 1531742.
      View in: PubMed
    67. Smith RC, Leung J, Keith FM, Merrick S, Mangano DT. Ventricular dysrhythmias in patients undergoing coronary artery bypass graft surgery: incidence, characteristics, and prognostic importance. Study of Perioperative Ischemia (SPI) Research Group. Am Heart J. 1992 Jan; 123(1):73-81. PMID: 1370363.
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    68. Leung J, Goehner P, O'Kelly BF, Hollenberg M, Pineda N, Cason BA, Mangano DT. Isoflurane anesthesia and myocardial ischemia: comparative risk versus sufentanil anesthesia in patients undergoing coronary artery bypass graft surgery. The SPI (Study of Perioperative Ischemia) Research Group. Anesthesiology. 1991 May; 74(5):838-47. PMID: 1826989.
      View in: PubMed
    69. Smith RC, Leung J, Mangano DT. Postoperative myocardial ischemia in patients undergoing coronary artery bypass graft surgery. S.P.I. Research Group. Anesthesiology. 1991 Mar; 74(3):464-73. PMID: 2001026.
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    70. Leung J, O'Kelly BF, Mangano DT. Relationship of regional wall motion abnormalities to hemodynamic indices of myocardial oxygen supply and demand in patients undergoing CABG surgery. Anesthesiology. 1990 Nov; 73(5):802-14. PMID: 2240670.
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    71. Leung J, O'Kelly B, Browner WS, Tubau J, Hollenberg M, Mangano DT. Prognostic importance of postbypass regional wall-motion abnormalities in patients undergoing coronary artery bypass graft surgery. SPI Research Group. Anesthesiology. 1989 Jul; 71(1):16-25. PMID: 2787609.
      View in: PubMed
    72. Leung J, Schiller NB, Mangano DT. Transesophageal echocardiographic assessment of left ventricular function. Int J Card Imaging. 1989; 5(1):63-70. PMID: 2693536.
      View in: PubMed
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