Shylaja Srinivasan, MD, MAS

Photo of Shylaja Srinivasan, MD, MAS
Title(s)Associate Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th Street, #4634
San Francisco CA 94158
PronounsShe/Her/Hers
ORCID ORCID Icon0000-0002-8049-6370 Additional info
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    Collapse Overview 
    Collapse overview
    I am a physician-scientist and Associate Professor of Pediatrics in the Division of Pediatric Endocrinology at UCSF. My clinical and scientific focus is on prediabetes and type 2 diabetes in youth. Specifically, I use pharmacologic and genetic approaches to evaluate pathophysiology and therapeutic strategies for youth with prediabetes and type 2 diabetes. I lead the Progress in Diabetes Genetics in Youth (ProDiGY) study group, a genetics consortium that studies the genetics of type 2 diabetes and related traits in youth. I am also the PI at UCSF for the national multicenter DISCOVERY of Risk Factors for Type 2 Diabetes in Youth Study in addition to other NIH and industry sponsored studies. Clinically, I direct
    the type 2 diabetes program at the UCSF Madison Clinic for Pediatric Diabetes. I am also a Co-Program Director for the pediatric endocrinology fellowship training program.

    Collapse Biography 
    Collapse education and training
    Pondicherry Institute of Medical Sciences, Pondicherry, IndiaMBBS2008
    SUNY Downstate Medical Center, Brooklyn, NYPediatric residency training 2012
    Tufts Medical Center, Boston, MAPediatric residency training 2013
    Massachusetts General Hospital, Boston, MAPediatric endocrinology fellowship training 2016
    University of California, San Francisco, CA2021Diversity, Equity, and Inclusion Champion Training
    University of California, San Francisco, CAMAS2022Clinical Research
    Collapse awards and honors
    Pediatric Endocrine Society2016  - 2017Clinical Scholar Award
    Pediatric Endocrine Society 2018  - 2019Clinical Scholar Award
    Pediatric Endocrine Society 2024Young Investigator Award

    Collapse Research 
    Collapse research activities and funding
    DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
    NIH U01DK134971Jun 15, 2026 - Jun 14, 2029
    Role: Principal-Investigator for UCSF site
    Understanding the Impact of Early Life Factors on Cardiometabolic Risk throughout the Life Course in a Large Population-based Cohort of Adolescents and Young Adults
    NIH R01HL177516Feb 1, 2025 - Nov 30, 2028
    Role: Co-Investigator
    Population-based Incidence, Time Trends, and Early Life Factors Associated with Type 2 Diabetes Among Asian American, Native Hawaiian, and Pacific Islander Adolescents and Young Adults
    NIH R01DK139116Jan 28, 2025 - Dec 31, 2028
    Role: Co-Investigator
    Pathophysiological sub-typing of pediatric type 2 diabetes based on clinical and genetic clustering methods
    NIH/NIDDK R03DK138213Dec 1, 2024 - Nov 30, 2026
    Role: Principal Investigator
    GEneration and assessment of Multi-omic informed Subtypes of Type 2 Diabetes in Diverse Populations (GEMS-T2D)
    NIH U01DK140757Sep 1, 2024 - Aug 31, 2029
    Role: Co-Investigator
    Artificial intelligence-based methods to predict disease progression in youth with type 2 diabetes: a digital twin study
    American Diabetes Association P0574975Jul 1, 2024 - Jun 30, 2027
    Role: Principal Investigator
    A comprehensive approach to understanding the determinants of metformin pharmacokinetics and pharmacodynamics in youth with type 2 diabetes
    NIH/NIDDK 1K23DK120932-01A1Jul 15, 2020 - Apr 30, 2025
    Collapse Clinical Trials

    Collapse Featured Content 

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic and Clinical Factors Associated With Metformin Plasma Concentrations Following an Acute Metformin Challenge. J Clin Endocrinol Metab. 2026 Jul 03. Kuo B, Nam S, Kaur V, Jones F, Mercader JM, Yee SW, Florez JC, Srinivasan S, Li JH. PMID: 42394225.
      View in: PubMed   Mentions:    Fields:    
    2. Beyond one-size-fits-all metformin dosing in youth. Pediatr Res. 2026 Jun 10. Yen K, Tryggestad JB, Srinivasan S. PMID: 42270812.
      View in: PubMed   Mentions:    Fields:    
    3. Novel Phenotypic Clusters of Youth-Onset Type 2 Diabetes Offer No Added Prognostic Value to Simple Clinical Measures. Diabetes Care. 2026 01 01; 49(1):137-146. Kreienkamp RJ, Smith K, Wangden TY, Deutsch AJ, Gage SD, Bellatorre A, Dabelea DM, D'Agostino RB, Dolan LM, Florez JC, Jensen ET, Pihoker C, Pollin TI, Shah AS, Szczerbinski L, Udler MS, Srinivasan S. PMID: 41237324; PMCID: PMC12719710.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Cohort prevalence of young-onset type 2 diabetes in South Asia: A systematic review. Diabetes Res Clin Pract. 2025 Mar; 221:112013. Reji S, Sankaraeswaran M, Ulagamathesan V, Wesley H, Ramesh G, Srinivasan S, Misra S, Mohan Anjana R, Unnikrishnan R, Mohan V, Amutha A. PMID: 39923964.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. MODY Calculator and Clinical Features Routinely Used to Distinguish MODY From Type 2 Diabetes in Adults Perform Poorly for Youth Clinically Diagnosed With Type 2 Diabetes. Diabetes Care. 2025 Jan 01; 48(1):e3-e5. Kreienkamp RJ, Shields BM, Pollin TI, Shah AS, Liese AD, Bellatorre A, Pihoker C, Tosur M, Florez JC, Srinivasan S, Hattersley AT, Udler MS, Redondo MJ. PMID: 39556464; PMCID: PMC11664197.
      View in: PubMed   Mentions: 3     Fields:    
    6. Type 2 Diabetes Mellitus in Youth. Pediatric Endocrinology. 2024 Dec 27; 837-858. Srinivasan SS, Levitsky LL. .
      View in: Publisher Site   Mentions:
    7. Desmopressin dosing in children using real-world data and pharmacokinetic/pharmacodynamic model simulations. Pediatr Res. 2025 Jun; 97(7):2449-2453. Yen K, Hughes E, Savic R, Srinivasan S. PMID: 39462098; PMCID: PMC12058421.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Measuring Up: Do Pediatric Endocrinology Fellows' Career Expectations Align with Workforce Reality? J Pediatr. 2024 Dec; 275:114321. Nahata L, Srinivasan S, Roche CI, Leavens KF, Kim MS, Levenson A, Topor LS, Singer K, McCormack S. PMID: 39304117.
      View in: PubMed   Mentions:    Fields:    
    9. Polygenic risk for obesity and body dissatisfaction: beyond BMI. Pediatr Res. 2024 Dec; 96(7):1545-1547. Jeter KM, Srinivasan S, Tryggestad JB. PMID: 39103630.
      View in: PubMed   Mentions:    Fields:    
    10. Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes. Diabetes. 2024 08 01; 73(8):1352-1360. Billings LK, Jablonski KA, Pan Q, Florez JC, Franks PW, Goldberg RB, Hivert MF, Kahn SE, Knowler WC, Lee CG, Merino J, Huerta-Chagoya A, Mercader JM, Raghavan S, Shi Z, Srinivasan S, Xu J, Udler MS. PMID: 38758294; PMCID: PMC11262049.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Obes Pillars. 2024 Sep; 11:100118. Seetharaman S, Allen IE, Gadgil M, Srinivasan S, Topor LS, Kanaya AM. PMID: 39139780; PMCID: PMC11321434.
      View in: PubMed   Mentions: 1  
    12. Pubertal Timing Across Asian American, Native Hawaiian, and Pacific Islander Subgroups. JAMA Netw Open. 2024 05 01; 7(5):e2410253. Kubo A, Acker J, Aghaee S, Kushi LH, Quesenberry CP, Greenspan LC, Srinivasan S, Kanaya AM, Deardorff J. PMID: 38739393; PMCID: PMC11091761.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. Res Sq. 2024 Mar 28. Seetharaman S, Allen I, Gadgil M, Srinivasan S, Topor L, Kanaya A. PMID: 38585953; PMCID: PMC10996820.
      View in: PubMed   Mentions:
    14. Genetic architecture and biology of youth-onset type 2 diabetes. Nat Metab. 2024 Feb; 6(2):226-237. Kwak SH, Srinivasan S, Chen L, Todd J, Mercader JM, Jensen ET, Divers J, Mottl AK, Pihoker C, Gandica RG, Laffel LM, Isganaitis E, Haymond MW, Levitsky LL, Pollin TI, Florez JC, Flannick J, Progress in Diabetes Genetics in Youth (ProDiGY) consortium. PMID: 38278947; PMCID: PMC10896722.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    15. Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies. Bioinformatics. 2023 12 01; 39(12). Pham DT, Westerman KE, Pan C, Chen L, Srinivasan S, Isganaitis E, Vajravelu ME, Bacha F, Chernausek S, Gubitosi-Klug R, Divers J, Pihoker C, Marcovina SM, Manning AK, Chen H. PMID: 38039147; PMCID: PMC10724851.
      View in: PubMed   Mentions: 1     Fields:    
    16. A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies. J Endocr Soc. 2023 Oct 09; 7(11):bvad123. Srinivasan S, Wu P, Mercader JM, Udler MS, Porneala BC, Bartz TM, Floyd JS, Sitlani C, Guo X, Haessler J, Kooperberg C, Liu J, Ahmad S, van Duijn C, Liu CT, Goodarzi MO, Florez JC, Meigs JB, Rotter JI, Rich SS, Dupuis J, Leong A. PMID: 37841955; PMCID: PMC10576255.
      View in: PubMed   Mentions: 1  
    17. Current insights and emerging trends in early-onset type 2 diabetes. Lancet Diabetes Endocrinol. 2023 10; 11(10):768-782. Misra S, Ke C, Srinivasan S, Goyal A, Nyriyenda MJ, Florez JC, Khunti K, Magliano DJ, Luk A. PMID: 37708901.
      View in: PubMed   Mentions: 100     Fields:    Translation:Humans
    18. Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP). Diabetes. 2023 08 01; 72(8):1161-1172. Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC, Diabetes Prevention Program Research Group:. PMID: 36525397; PMCID: PMC10382652.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    19. Greater Improvement in Obesity Among Children With Prediabetes in a Clinical Weight Management Program. Child Obes. 2024 May; 20(4):262-269. Tester JM, Xiao L, Chau CA, Tinajero-Deck L, Srinivasan S, Rosas LG. PMID: 37347933; PMCID: PMC11238840.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes. Pediatr Diabetes. 2023; 2023. Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson ER, Yee SW, Giacomini KM, Pollin T, Florez JC. PMID: 38590442; PMCID: PMC11000826.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes. Res Sq. 2023 May 18. Kwak SH, Srinivasan S, Chen L, Todd J, Mercader J, Jensen E, Divers J, Mottl A, Pihoker C, Gandica R, Laffel L, Isganaitis E, Haymond M, Levitsky L, Pollin T, Florez J, Flannick J. PMID: 37292813; PMCID: PMC10246295.
      View in: PubMed   Mentions:
    22. The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes. Diabetologia. 2023 07; 66(7):1273-1288. Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbinski L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperberg C, Raffield LM, Haiman C, Sun Q, McCormick JB, Fisher-Hoch SP, Ordoñez ML, Meigs J, Baier LJ, González-Villalpando C, González-Villalpando ME, Orozco L, García-García L, Moreno-Estrada A, Mexican Biobank, Aguilar-Salinas CA, Tusié T, Dupuis J, Ng MCY, Manning A, Highland HM, Cnop M, Hanson R, Below J, Florez JC, Leong A, Mercader JM. PMID: 37148359; PMCID: PMC10244266.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    23. Pancreatic autoantibodies in individuals with a clinical diagnosis of type 2 diabetes mellitus. Journal of Pediatric Endocrinology and Diabetes. 2023 Jan 1; 3(1):15-19. Ferrell FJ, Kohn KM, Srinivasan SS. .
      View in: Publisher Site   Mentions:
    24. Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life. J Diabetes Sci Technol. 2024 Jul; 18(4):911-919. Chesser H, Srinivasan S, Puckett C, Gitelman SE, Wong JC. PMID: 36416098; PMCID: PMC11307231.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    25. The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes. J Pediatr. 2022 12; 251:51-59.e2. Magge SN, Wolf RM, Pyle L, Brown EA, Benavides VC, Bianco ME, Chao LC, Cymbaluk A, Balikcioglu PG, Halpin K, Hsia DS, Huerta-Saenz L, Kim JJ, Kumar S, Levitt Katz LE, Marks BE, Neyman A, O'Sullivan KL, Pillai SS, Shah AS, Shoemaker AH, Siddiqui JAW, Srinivasan S, Thomas IH, Tryggestad JB, Yousif MF, Kelsey MM, COVID-19 and Type 2 Diabetes Consortium. PMID: 35985535; PMCID: PMC9383958.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansPHPublic Health
    26. Rickets in a child with prolonged acquired hypothyroidism secondary to Hashimoto's thyroiditis. Endocrinol Diabetes Metab Case Rep. 2022 Aug 01; 2022. Schulmeister C, Lee J, Perwad F, Long R, Srinivasan S. PMID: 35979838; PMCID: PMC9422259.
      View in: PubMed   Mentions:
    27. The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road Ahead. J Pediatr. 2022 08; 247:17-21. Srinivasan S, Todd J. PMID: 35660490; PMCID: PMC9833991.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes. J Endocr Soc. 2021 Nov 01; 5(11):bvab139. Santoro N, Chen L, Todd J, Divers J, Shah AS, Gidding SS, Burke B, Haymond M, Lange L, Marcovina S, Flannick J, Caprio S, Florez JC, Srinivasan S. PMID: 34568709; PMCID: PMC8459445.
      View in: PubMed   Mentions: 2  
    29. Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration. Diabetes Care. 2021 Aug 06. Todd JN, Kleinberger JW, Zhang H, Srinivasan S, Tollefsen SE, Levitsky LL, Levitt Katz LE, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, Florez JC, Pollin TI. PMID: 34362814; PMCID: PMC8929184.
      View in: PubMed   Mentions: 16     Fields:    
    30. Adjunctive Therapies to Optimize Closed-loop Glucose Control. J Diabetes Sci Technol. 2021 11; 15(6):1243-1251. Srinivasan S, Ekhlaspour L, Cengiz E. PMID: 34315267; PMCID: PMC8655279.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    31. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes. 2021 04; 70(4):996-1005. Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, Dabelea D, Florez JC, ProDiGY Consortium. PMID: 33479058; PMCID: PMC7980197.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    32. Overview and Initial Management of Type 2 Diabetes in Youth. . 2020 Sep 26; 313-321. Chesser CH, Srinivasan SS. .
      View in: Publisher Site   Mentions:
    33. A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program. J Endocr Soc. 2019 Sep 01; 3(9):1663-1677. Srinivasan S, Jablonski KA, Knowler WC, Dagogo-Jack S, E Kahn S, Boyko EJ, Bray GA, Horton ES, Hivert MF, Goldberg R, Chen L, Mercader J, Harden M, Florez JC, Diabetes Prevention Program Research Group. PMID: 31428720; PMCID: PMC6694040.
      View in: PubMed   Mentions: 8  
    34. Advances in the Genetics of Youth-Onset Type 2 Diabetes. Curr Diab Rep. 2018 06 22; 18(8):57. Todd JN, Srinivasan S, Pollin TI. PMID: 29931398; PMCID: PMC6051541.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    35. Pharmacogenetics of Antidiabetic Drugs. Adv Pharmacol. 2018; 83:361-389. Srinivasan S, Yee SW, Giacomini KM. PMID: 29801583; PMCID: PMC10999281.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    36. TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care. 2018 03; 41(3):554-561. Srinivasan S, Kaur V, Chamarthi B, Littleton KR, Chen L, Manning AK, Merino J, Thomas MK, Hudson M, Goldfine A, Florez JC. PMID: 29326107; PMCID: PMC5829963.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    37. Radovick and Misra’s Pediatric Endocrinology: A Practical Clinical Guide, Springer International. Type 2 diabetes in youth. 2018; 737-754. Srinivasan S., Levitsky L.
    38. In Advances in Pharmacology, Elsevier. The Pharmacogenetics of Anti-Diabetic Drugs. 2018; 361-381. Srinivasan S., Yee SW., Giacomini K .
    39. Type 2 Diabetes Mellitus in Youth. Pediatric Endocrinology. 2018 Jan 1; 737-753. Srinivasan SS, Levitsky LL. .
      View in: Publisher Site   Mentions:
    40. Calcium and Vitamin D Supplement Prescribing Practices among Providers Caring for Children with Autism Spectrum Disorders: Are We Addressing Bone Health? Autism Res Treat. 2016; 2016:6763205. Srinivasan S, O'Rourke J, Bersche Golas S, Neumeyer A, Misra M. PMID: 27042348; PMCID: PMC4799806.
      View in: PubMed   Mentions: 6  
    41. Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill". Clin Pharmacol Ther. 2015 Aug; 98(2):162-9. Srinivasan S, Florez JC. PMID: 25974616; PMCID: PMC4511706.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsPHPublic Health
    42. Hyperthyroidism in children. Pediatr Rev. 2015 Jun; 36(6):239-48. Srinivasan S, Misra M. PMID: 26034254.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    43. Comparison of bone age readings by pediatric endocrinologists and pediatric radiologists using two bone age atlases. Pediatr Radiol. 2011 Jun; 41(6):690-3. Kaplowitz P, Srinivasan S, He J, McCarter R, Hayeri MR, Sze R. PMID: 21161206.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
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