Shylaja Srinivasan, MD, MAS

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th. Street, #4634
San Francisco CA 94158
Phone415-353-9084
ORCID ORCID Icon0000-0002-8049-6370 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Pondicherry Institute of Medical Sciences, Pondicherry, IndiaMBBS2008
    SUNY Downstate Medical Center, Brooklyn, NYPediatric residency training 2012
    Tufts Medical Center, Boston, MAPediatric residency training 2013
    Massachusetts General Hospital, Boston, MAPediatric endocrinology fellowship training 2016
    University of California, San Francisco, CA2021Diversity, Equity, and Inclusion Champion Training
    University of California, San Francisco, CAMAS2022Clinical Research
    Collapse Awards and Honors
    Pediatric Endocrine Society2016  - 2017Clinical Scholar Award
    Pediatric Endocrine Society 2018  - 2019Clinical Scholar Award
    Pediatric Endocrine Society 2024Young Investigator Award

    Collapse Overview 
    Collapse Overview
    I am a clinican-scientist and Assistant Professor of Pediatrics in the Division of Pediatric Endocrinology at UCSF. My clinical and scientific focus is on prediabetes and type 2 diabetes in youth. Specifically, I use pharmacologic and genetic approaches to evaluate pathophysiology and therapeutic strategies for youth with prediabetes and type 2 diabetes. I lead the type 2 diabetes program at the UCSF Madison Clinic for Pediatric Diabetes. I am also an Associate Program Director for the fellowship training program.

    Collapse Research 
    Collapse Research Activities and Funding
    Pathophysiological sub-typing of pediatric type 2 diabetes based on clinical and genetic clustering methods
    NIH/NIDDK R03DK138213Dec 1, 2024 - Nov 30, 2026
    Role: Principal Investigator
    A comprehensive approach to understanding the determinants of metformin pharmacokinetics and pharmacodynamics in youth with type 2 diabetes
    NIH/NIDDK 1K23DK120932-01A1Jul 15, 2020 - Apr 30, 2025

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic architecture and biology of youth-onset type 2 diabetes. Nat Metab. 2024 Feb; 6(2):226-237. Kwak SH, Srinivasan S, Chen L, Todd J, Mercader JM, Jensen ET, Divers J, Mottl AK, Pihoker C, Gandica RG, Laffel LM, Isganaitis E, Haymond MW, Levitsky LL, Pollin TI, Florez JC, Flannick J, Progress in Diabetes Genetics in Youth (ProDiGY) consortium. PMID: 38278947; PMCID: PMC10896722.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies. Bioinformatics. 2023 12 01; 39(12). Pham DT, Westerman KE, Pan C, Chen L, Srinivasan S, Isganaitis E, Vajravelu ME, Bacha F, Chernausek S, Gubitosi-Klug R, Divers J, Pihoker C, Marcovina SM, Manning AK, Chen H. PMID: 38039147; PMCID: PMC10724851.
      View in: PubMed   Mentions:    Fields:    
    3. A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies. J Endocr Soc. 2023 Oct 09; 7(11):bvad123. Srinivasan S, Wu P, Mercader JM, Udler MS, Porneala BC, Bartz TM, Floyd JS, Sitlani C, Guo X, Haessler J, Kooperberg C, Liu J, Ahmad S, van Duijn C, Liu CT, Goodarzi MO, Florez JC, Meigs JB, Rotter JI, Rich SS, Dupuis J, Leong A. PMID: 37841955; PMCID: PMC10576255.
      View in: PubMed   Mentions: 1  
    4. Current insights and emerging trends in early-onset type 2 diabetes. Lancet Diabetes Endocrinol. 2023 10; 11(10):768-782. Misra S, Ke C, Srinivasan S, Goyal A, Nyriyenda MJ, Florez JC, Khunti K, Magliano DJ, Luk A. PMID: 37708901.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP). Diabetes. 2023 08 01; 72(8):1161-1172. Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC, Diabetes Prevention Program Research Group:. PMID: 36525397; PMCID: PMC10382652.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    6. Greater Improvement in Obesity Among Children With Prediabetes in a Clinical Weight Management Program. Child Obes. 2023 Jun 21. Tester JM, Xiao L, Chau CA, Tinajero-Deck L, Srinivasan S, Rosas LG. PMID: 37347933.
      View in: PubMed   Mentions:    Fields:    
    7. 1091-P: Genetic Ancestry Influences Metformin Treatment Response in Youth with Type 2 Diabetes. Diabetes. 2023 Jun 20; 72(Supplement_1). SRINIVASAN SS, CHEN CL, KELSEY KM, TODD TJ, ARSLANIAN AS, CHANG CN, LAFFEL LL, LEVITSKY LL, SPRAGUE SJ, POLLIN PT, MANNING MA, FLOREZ FJ. .
      View in: Publisher Site   Mentions:
    8. Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes. Pediatr Diabetes. 2023; 2023. Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson ER, Yee SW, Giacomini KM, Pollin T, Florez JC. PMID: 38590442; PMCID: PMC11000826.
      View in: PubMed   Mentions:
    9. Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes. Res Sq. 2023 May 18. Kwak SH, Srinivasan S, Chen L, Todd J, Mercader J, Jensen E, Divers J, Mottl A, Pihoker C, Gandica R, Laffel L, Isganaitis E, Haymond M, Levitsky L, Pollin T, Florez J, Flannick J. PMID: 37292813; PMCID: PMC10246295.
      View in: PubMed   Mentions:
    10. The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes. Diabetologia. 2023 07; 66(7):1273-1288. Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbinski L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperberg C, Raffield LM, Haiman C, Sun Q, McCormick JB, Fisher-Hoch SP, Ordoñez ML, Meigs J, Baier LJ, González-Villalpando C, González-Villalpando ME, Orozco L, García-García L, Moreno-Estrada A, Mexican Biobank, Aguilar-Salinas CA, Tusié T, Dupuis J, Ng MCY, Manning A, Highland HM, Cnop M, Hanson R, Below J, Florez JC, Leong A, Mercader JM. PMID: 37148359; PMCID: PMC10244266.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life. J Diabetes Sci Technol. 2022 Nov 23; 19322968221139873. Chesser H, Srinivasan S, Puckett C, Gitelman SE, Wong JC. PMID: 36416098.
      View in: PubMed   Mentions: 5     Fields:    
    12. The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes. J Pediatr. 2022 12; 251:51-59.e2. Magge SN, Wolf RM, Pyle L, Brown EA, Benavides VC, Bianco ME, Chao LC, Cymbaluk A, Balikcioglu PG, Halpin K, Hsia DS, Huerta-Saenz L, Kim JJ, Kumar S, Levitt Katz LE, Marks BE, Neyman A, O'Sullivan KL, Pillai SS, Shah AS, Shoemaker AH, Siddiqui JAW, Srinivasan S, Thomas IH, Tryggestad JB, Yousif MF, Kelsey MM, COVID-19 and Type 2 Diabetes Consortium. PMID: 35985535; PMCID: PMC9383958.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    13. Rickets in a child with prolonged acquired hypothyroidism secondary to Hashimoto's thyroiditis. Endocrinol Diabetes Metab Case Rep. 2022 Aug 01; 2022. Schulmeister C, Lee J, Perwad F, Long R, Srinivasan S. PMID: 35979838; PMCID: PMC9422259.
      View in: PubMed   Mentions:
    14. The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road Ahead. J Pediatr. 2022 08; 247:17-21. Srinivasan S, Todd J. PMID: 35660490; PMCID: PMC9833991.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes. J Endocr Soc. 2021 Nov 01; 5(11):bvab139. Santoro N, Chen L, Todd J, Divers J, Shah AS, Gidding SS, Burke B, Haymond M, Lange L, Marcovina S, Flannick J, Caprio S, Florez JC, Srinivasan S. PMID: 34568709; PMCID: PMC8459445.
      View in: PubMed   Mentions: 1  
    16. Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration. Diabetes Care. 2021 Aug 06. Todd JN, Kleinberger JW, Zhang H, Srinivasan S, Tollefsen SE, Levitsky LL, Levitt Katz LE, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, Florez JC, Pollin TI. PMID: 34362814; PMCID: PMC8929184.
      View in: PubMed   Mentions: 7     Fields:    
    17. Adjunctive Therapies to Optimize Closed-loop Glucose Control. J Diabetes Sci Technol. 2021 11; 15(6):1243-1251. Srinivasan S, Ekhlaspour L, Cengiz E. PMID: 34315267; PMCID: PMC8655279.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. 23-OR: ADA Presidents’ Select Abstract: Genetic Architecture and Novel Genes Implicated in Youth-Onset Type 2 Diabetes. Diabetes. 2021 Jun 21; 70(Supplement 1):23-or. KWAK KS, SRINIVASAN SS, CHEN CL, TODD TJ, JENSEN JE, DIVERS DJ, MOTTL MA, PIHOKER PC, GANDICA GR, LAFFEL LL, ISGANAITIS IE, HAYMOND HM, LEVITSKY LL, POLLIN PT, FLOREZ FJ, FLANNICK FJ. .
      View in: Publisher Site   Mentions:
    19. 249-OR: Type 2 Diabetes (T2D) Genetic Clusters for Association with Glycemic Responses to Intervention for Diabetes Prevention. Diabetes. 2021 Jun 21; 70(Supplement 1):249-or. BILLINGS BL, JABLONSKI JK, FRANKS FP, GOLDBERG GR, HIVERT HM, KAHN KS, KNOWLER KW, LEE LC, MERINO MJ, RAGHAVAN RS, SRINIVASAN SS, XU XJ, FLOREZ FJ, UDLER UM. .
      View in: Publisher Site   Mentions:
    20. 28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP). Diabetes. 2021 Jun 21; 70(Supplement 1):28-or. LI LJ, PERRY PJ, JABLONSKI JK, CHEN CL, SRINIVASAN SS, TODD TJ, HARDEN HM, MERCADER MJ, FRANKS FP, HANSON HR, KAHN KS, KNOWLER KW, POLLIN PT, FLOREZ FJ, GROUP GD. .
      View in: Publisher Site   Mentions:
    21. 900-P: Continuous Glucose Monitoring in Youth with Type 2 Diabetes: A Pilot and Feasibility Study. Diabetes. 2021 Jun 21; 70(Supplement 1):900-p. CHESSER CH, SRINIVASAN SS, WONG WJ. .
      View in: Publisher Site   Mentions:
    22. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes. 2021 04; 70(4):996-1005. Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, Dabelea D, Florez JC, ProDiGY Consortium. PMID: 33479058; PMCID: PMC7980197.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    23. Overview and Initial Management of Type 2 Diabetes in Youth. . 2020 Sep 26; 313-321. Chesser CH, Srinivasan SS. .
      View in: Publisher Site   Mentions:
    24. A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program. J Endocr Soc. 2019 Sep 01; 3(9):1663-1677. Srinivasan S, Jablonski KA, Knowler WC, Dagogo-Jack S, E Kahn S, Boyko EJ, Bray GA, Horton ES, Hivert MF, Goldberg R, Chen L, Mercader J, Harden M, Florez JC, Diabetes Prevention Program Research Group. PMID: 31428720; PMCID: PMC6694040.
      View in: PubMed   Mentions: 7  
    25. 177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium. Diabetes. 2019 Jun 1; 68(Supplement 1):177-or. CHEN CL, SRINIVASAN SS, SANTORO SN, TODD TJ, DIVERS DJ, SHAH SA, GIDDING GS, BURKE BB, HAYMOND HM, LANGE LL, MARCOVINA MS, CHAIT CA, FLANNICK FJ, CAPRIO CS, FLOREZ FJ. .
      View in: Publisher Site   Mentions:
    26. MON-268 A Rare Case of Primary Hypoaldosteronism in a Newborn. Journal of the Endocrine Society. 2019 Apr 15; 3(Suppl 1). Mody MA, Lee LJ, Tenney TJ, Srinivasan SS. .
      View in: Publisher Site   Mentions:
    27. A Comprehensive Type 1 Diabetes Genetic Risk Score Is Associated with Type 2 Diabetes in the Framingham Heart Study. Diabetes. 2018 Jun 22; 67(Supplement 1):1715-p. SRINIVASAN SS, LEONG LA, UDLER UM, PORNEALA PB, MEIGS MJ, RICH RS, DUPUIS DJ. .
      View in: Publisher Site   Mentions:
    28. Advances in the Genetics of Youth-Onset Type 2 Diabetes. Curr Diab Rep. 2018 06 22; 18(8):57. Todd JN, Srinivasan S, Pollin TI. PMID: 29931398; PMCID: PMC6051541.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    29. Pharmacogenetics of Antidiabetic Drugs. Adv Pharmacol. 2018; 83:361-389. Srinivasan S, Yee SW, Giacomini KM. PMID: 29801583.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    30. The First Genome-Wide Association Study (GWAS) for Type 2 Diabetes in Youth from the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration. Diabetes. 2018 May 1; 67(Supplement 1):1703-p. SRINIVASAN SS, TODD TJ, CHEN CL, DIVERS DJ, GIDDING GS, CHERNAUSEK CS, GUBITOSI-KLUG GR, KELSEY KM, SHAH SR, BLACK BM, WAGENKNECHT WL, MERCADER MJ, MANNING MA, FLANNICK FJ, DABELEA DD, FLOREZ FJ. .
      View in: Publisher Site   Mentions:
    31. Monogenic Diabetes in the Progress for Diabetes Genetics in Youth (ProDiGY) Collaboration. Diabetes. 2018 May 1; 67(Supplement 1):268-or. TODD TJ, KLEINBERGER KJ, SRINIVASAN SS, TOLLEFSEN TS, LEVITSKY LL, KATZ KL, TRYGGESTAD TJ, BACHA BF, IMPERATORE IG, LAWRENCE LJ, PIHOKER PC, DIVERS DJ, FLANNICK FJ, DABELEA DD, FLOREZ FJ, POLLIN PT. .
      View in: Publisher Site   Mentions:
    32. TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care. 2018 03; 41(3):554-561. Srinivasan S, Kaur V, Chamarthi B, Littleton KR, Chen L, Manning AK, Merino J, Thomas MK, Hudson M, Goldfine A, Florez JC. PMID: 29326107; PMCID: PMC5829963.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    33. Radovick and Misra’s Pediatric Endocrinology: A Practical Clinical Guide, Springer International. Type 2 diabetes in youth. 2018; 737-754. Srinivasan S., Levitsky L.
    34. In Advances in Pharmacology, Elsevier. The Pharmacogenetics of Anti-Diabetic Drugs. 2018; 361-381. Srinivasan S., Yee SW., Giacomini K .
    35. Type 2 Diabetes Mellitus in Youth. Pediatric Endocrinology. 2018 Jan 1; 737-753. Srinivasan SS, Levitsky LL. .
      View in: Publisher Site   Mentions:
    36. Calcium and Vitamin D Supplement Prescribing Practices among Providers Caring for Children with Autism Spectrum Disorders: Are We Addressing Bone Health? Autism Res Treat. 2016; 2016:6763205. Srinivasan S, O'Rourke J, Bersche Golas S, Neumeyer A, Misra M. PMID: 27042348; PMCID: PMC4799806.
      View in: PubMed   Mentions: 5  
    37. Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill". Clin Pharmacol Ther. 2015 Aug; 98(2):162-9. Srinivasan S, Florez JC. PMID: 25974616; PMCID: PMC4511706.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsPHPublic Health
    38. Hyperthyroidism in children. Pediatr Rev. 2015 Jun; 36(6):239-48. Srinivasan S, Misra M. PMID: 26034254.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    39. Hyperthyroidism in Children. Pediatrics in Review. 2015 Jun 1; 36(6):239-248. Srinivasan SS, Misra MM. .
      View in: Publisher Site   Mentions:
    40. Comparison of bone age readings by pediatric endocrinologists and pediatric radiologists using two bone age atlases. Pediatr Radiol. 2011 Jun; 41(6):690-3. Kaplowitz P, Srinivasan S, He J, McCarter R, Hayeri MR, Sze R. PMID: 21161206.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
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