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Kathy Giacomini, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-476-1936
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    Other Positions
    Title(s)Co-Director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation


    Collapse Biography 
    Collapse Awards and Honors
    American Association of Colleges of Pharmacy2018Volwiler Research Achievement Award
    Swedish Academy of Pharmaceutical Scientists2011Scheele Award
    Therapeutic Frontiers Lecture Award2010Therapeutic Frontiers Lecture Award
    Postdoctoral Scholars Association, University of California, San Francisco2009Outstanding Mentor Award
    American Society for Clinical Pharmacology and Therapeutics2009Rawls-Palmer Progress in Medicine Award
    Japan Society for the Promotion of Science2008Invitation Fellowship Program for Research in Japan
    Academy of Pharmaceutical Sciences and Technology, Japan2007International Woman Scientist Award
    Pharmaceutical Sciences World Congress2007Research Achievement Award
    National Academy of Medicine2006Elected Member
    American Association of Pharmaceutical Scientists2006Distinguished Scientist Award in Drug Metabolism
    American Association of Colleges of Pharmacy2005Paul Dawson Biotechnology Award
    State University of New York at Buffalo2002Distinguished Gerhard Levy Lectureship
    U.S. Food and Drug Administration2002Distinguished Bill Abram's Lectureship
    University of California, San Francisco2002Honored Celebrating Women Faculty
    University of Kentucky2000Guttman Lecturer
    International Pharmaceutical Federation (FIP)1999Scientist of the Year
    University of California, San Francisco1999Recognition Award for Distinguished Achievement of a Filipino at UCSF
    University of California, San Francisco1997Chancellor's Award for the Advancement of Women
    University of California, San Francisco1994Martin Luther King, Jr. Award for the Advancement of Minorities
    National Institutes of Health1992Fogarty International Fellowship
    American Society for Clinical Pharmacology and Therapeutics1990Leon Goldberg Young Investigator Award

    Collapse Overview 
    Collapse Overview
    The Giacomini research group focuses on expanding our understanding of membrane transporters. Membrane transporters are of great pharmacological importance, as they play a major role in drug efficacy by regulating drug disposition and distribution. Major questions addressed in the laboratory include: What is the in vivo role of membrane transporters in drug disposition and response? How does genetic variation in membrane transporters affect clinical drug response? What is the endogenous role of membrane transporters? And, what are the structural determinants of specificity?

    Dr. Kathy Giacomini is leading an effort to deorphan transporters in the Solute Carrier Superfamily, and to determine the clinical implications of specific genetic variants in membrane transporters. Research ventures, ranging from basic discovery to clinical studies, have demonstrated that common variants of membrane transporters contribute to differences in drug response in ethnically diverse populations. Ultimately, these studies will increase our knowledge of the genetic basis underlying drug response, and will contribute to advancing the era of personalized medicine. Furthermore, our studies will elucidate the genetic mechanisms of decreased drug response and, ultimately, contribute to improving drug design for safe and effective treatments of subgroups of patients who do not respond to standard treatments.

    Research in the laboratory focuses on drugs used in the treatment of diseases associated with metabolic syndrome. We are particularly interested in two key therapeutic agents, allopurinol, first-line medical therapy for gout and high uric acid levels, and the anti-diabetic drug, metformin, one of the world’s most widely prescribed drugs. In particular, our research focuses on discovering functional genetic variants that underlie variation in response to these drugs in large ethnically diverse patient populations. As a co-leader of the international MetGen consortium with over 10,000 patients from Europe and the U.S. on metformin, Giacomini and her collaborators are seeking to discover genetic factors that contribute to poor response to metformin. Importantly, her group is interested in understanding the molecular mechanisms responsible for metformin’s pharmacologic action. For allopurinol, we have discovered that genetic variants in membrane transporters contribute to variation in response to allopurinol. We are now seeking to understand the mechanisms through which the variants act on allopurinol response.

    Finally, Kathy Giacomini and her collaborator, Russ Altman of Stanford University are the Co-PIs of the UCSF–Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) funded by the Food and Drug Administration (FDA). Established in 2014, the UCSF-Stanford CERSI aims to advance the field of regulatory sciences and improve the development and evaluation of diagnostics, therapeutics and medical devices. The UCSF-Stanford CERSI is the first FDA funded CERSI on the west coast and seeks to address key challenges related to education and research that will advance the discovery and development of medical products.

    Collapse Research 
    Collapse Research Activities and Funding
    UCSF-Stanford Center of Excellence in Regulatory Science
    NIH U01FD005978Sep 15, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Discovery of Pharmacogenomic Biomarkers for Metformin Response
    NIH R01GM117163Sep 25, 2015 - Aug 31, 2019
    Role: Principal Investigator
    PGRN Administrative Coordination Hub, ACH (PGRN)
    NIH/NIGMS U24GM115370Jul 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Role of ABCG2 in the disposition and anti-hyperuricemic effects of allopurinol
    NIH R01DK103729Sep 20, 2014 - Jul 31, 2018
    Role: Principal Investigator
    UCSF-Stanford Center of Excellence in Regulatory Science and Innovation
    NIH U01FD004979Apr 15, 2014 - Mar 31, 2017
    Role: Principal Investigator
    Center for Structure of Membrane Proteins
    NIH/NIGMS U54GM094625Sep 30, 2010 - Jun 30, 2015
    Role: Co-Investigator
    A Comprehensive Platform for Transporter Mediated Drug-Drug Interaction Studies
    NIH R44GM086970Feb 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Pharmacogenomics of Membrane Transporters
    NIH U19GM061390Apr 1, 2000 - Jun 30, 2015
    Role: Principal Investigator
    Pharmacogenetics of Membrane Transporters
    NIH U01GM061390Apr 1, 2000 - Jul 14, 2010
    Role: Principal Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH/NIGMS R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF DRUG TRANSPORT
    NIH F06TW001776Jan 1, 1992
    Role: Principal Investigator
    CELLULAR MECHANISMS OF DRUG TRANSPORT IN CHOROID PLEXUS
    NIH R01GM042230Jan 1, 1991 - Dec 31, 2003
    Role: Principal Investigator
    Cellular Mechanisms of Drug Elimination
    NIH R01GM036780Apr 4, 1986 - May 31, 2012
    Role: Principal Investigator
    STEREOSELECTIVE PHARMACOKINETICS OF DRUGS IN THE KIDNEY
    NIH R01GM031254Mar 1, 1983 - Jun 30, 1989
    Role: Principal Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH/NIGMS P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Sep 29, 2006
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Sep 29, 2006
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Scientific considerations for global drug development. Sci Transl Med. 2020 Jul 29; 12(554). Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee HA, Cooke E, Peck CC, Kern SE, Hartman D, Hayashi Y, Marks PW, Altman RB, Lumpkin MM, Giacomini KM, Blaschke TF. PMID: 32727913.
      View in: PubMed   Mentions:    Fields:    
    2. The activities of drug inactive ingredients on biological targets. Science. 2020 07 24; 369(6502):403-413. Pottel J, Armstrong D, Zou L, Fekete A, Huang XP, Torosyan H, Bednarczyk D, Whitebread S, Bhhatarai B, Liang G, Jin H, Ghaemi SN, Slocum S, Lukacs KV, Irwin JJ, Berg EL, Giacomini KM, Roth BL, Shoichet BK, Urban L. PMID: 32703874.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter. Genes Dev. 2020 Jul 16. Lin L, Lemieux GA, Enogieru OJ, Giacomini KM, Ashrafi K. PMID: 32675325.
      View in: PubMed   Mentions:    Fields:    
    4. COVID-19: A Defining Moment for Clinical Pharmacology? Clin Pharmacol Ther. 2020 07; 108(1):11-15. van der Graaf PH, Giacomini KM. PMID: 32350861.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    5. Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):16009-16018. Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, Turnbaugh PJ. PMID: 32571913.
      View in: PubMed   Mentions:    Fields:    
    6. Oral Anticoagulants and Precision Medicine: Something Old, Something New. Clin Pharmacol Ther. 2020 Jun; 107(6):1273-1277. Shahin MH, Giacomini KM. PMID: 32390146.
      View in: PubMed   Mentions:    Fields:    
    7. Novel Technologies Enable Mechanistic Understanding and Modeling of Drug Exposure and Response. Clin Pharmacol Ther. 2020 May; 107(5):1045-1047. Giacomini KM. PMID: 32304600.
      View in: PubMed   Mentions:    Fields:    
    8. GenEpi: gene-based epistasis discovery using machine learning. BMC Bioinformatics. 2020 Feb 24; 21(1):68. Chang YC, Wu JT, Hong MY, Tung YA, Hsieh PH, Yee SW, Giacomini KM, Oyang YJ, Chen CY. PMID: 32093643.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP. Mol Pharm. 2020 03 02; 17(3):748-756. Zou L, Pottel J, Khuri N, Ngo HX, Ni Z, Tsakalozou E, Warren MS, Huang Y, Shoichet BK, Giacomini KM. PMID: 31990564.
      View in: PubMed   Mentions:    Fields:    
    10. Clinical Pharmacology & Therapeutics 2030. Clin Pharmacol Ther. 2020 01; 107(1):13-16. van der Graaf PH, Giacomini KM. PMID: 31863685.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). Am J Clin Nutr. 2020 01 01; 111(1):110-121. Vora B, Green EAE, Khuri N, Ballgren F, Sirota M, Giacomini KM. PMID: 31764942.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics. Clin Pharmacol Ther. 2020 01; 107(1):96-101. Yee SW, Do TP, Huang SM, Krauss RM, Kusuhara H, Sugiyama Y, Unadkat JD, Giacomini KM. PMID: 31774556.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities. Clin Pharmacol Ther. 2020 01; 107(1):57-61. Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF. PMID: 31696505.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PLoS Genet. 2019 09; 15(9):e1008208. Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM. PMID: 31553721.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. PLoS Genet. 2019 08; 15(8):e1008318. Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P. PMID: 31415568.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization. Clin Pharmacol Ther. 2019 11; 106(5):1083-1092. Cheung KWK, van Groen BD, Spaans E, van Borselen MD, de Bruijn ACJM, Simons-Oosterhuis Y, Tibboel D, Samsom JN, Verdijk RM, Smeets B, Zhang L, Huang SM, Giacomini KM, de Wildt SN. PMID: 31127606.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan. Bioorg Med Chem Lett. 2019 08 15; 29(16):2254-2258. Hall C, Wolfe H, Wells A, Chien HC, Colas C, Schlessinger A, Giacomini KM, Thomas AA. PMID: 31248771.
      View in: PubMed   Mentions:    Fields:    
    18. Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol. Clin Pharmacol Ther. 2019 09; 106(3):623-631. Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM. PMID: 30924126.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits. Hum Mutat. 2019 07; 40(7):983-995. Enogieru OJ, Ung PMU, Yee SW, Schlessinger A, Giacomini KM. PMID: 30950137.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    20. Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers. Clin Transl Sci. 2019 07; 12(4):388-399. Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM. PMID: 30982223.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation. Clin Pharmacol Ther. 2019 04; 105(4):815-818. Giacomini KM, Lin L, Altman RB. PMID: 30773618.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters. Clin Pharmacol Ther. 2019 02; 105(2):323-325. Zou L, Ni Z, Tsakalozou E, Giacomini KM. PMID: 30663035.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    23. Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. PLoS Biol. 2019 01; 17(1):e2006571. Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L. PMID: 30653498.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development. Clin Pharmacol Ther. 2018 11; 104(5):766-771. Giacomini KM, Galetin A, Huang SM. PMID: 30137696.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    25. Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium. Clin Pharmacol Ther. 2018 11; 104(5):836-864. Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L. PMID: 30347454.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    26. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018 08 23; 61(16):7358-7373. Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, Giacomini KM, Thomas AA. PMID: 30048132.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance. Clin Pharmacol Ther. 2018 11; 104(5):890-899. Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y. PMID: 30091177.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    28. Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium. Clin Pharmacol Ther. 2018 11; 104(5):803-817. Yee SW, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM. PMID: 29679469.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    29. ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision. Clin Pharmacol Ther. 2018 11; 104(5):781-784. Zamek-Gliszczynski MJ, Chu X, Cook JA, Custodio JM, Galetin A, Giacomini KM, Lee CA, Paine MF, Ray AS, Ware JA, Wittwer MB, Zhang L. PMID: 29761830.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    30. Pharmacogenetics of Antidiabetic Drugs. Adv Pharmacol. 2018; 83:361-389. Srinivasan S, Yee SW, Giacomini KM. PMID: 29801583.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity. Mol Pharmacol. 2018 07; 94(1):689-699. Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM. PMID: 29720497.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    32. Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. PLoS Biol. 2018 04; 16(4):e2002907. Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM. PMID: 29659562.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    33. Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1428-1440. Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA. PMID: 29650774.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions. Clin Pharmacol Ther. 2018 05; 103(5):758-760. Zamek-Gliszczynski MJ, Giacomini KM, Zhang L. PMID: 29193038.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response. Clin Pharmacol Ther. 2018 02; 103(2):233-242. Brackman DJ, Giacomini KM. PMID: 29023674.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    36. PharmGKB summary: very important pharmacogene information for ABCG2. Pharmacogenet Genomics. 2017 11; 27(11):420-427. Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE. PMID: 28858993.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine. Clin Pharmacol Ther. 2017 Dec; 102(6):897-902. Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM. PMID: 28795399.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. PBPK Modeling of the Effect of Reduced Kidney Function on the Pharmacokinetics of Drugs Excreted Renally by Organic Anion Transporters. Clin Pharmacol Ther. 2018 03; 103(3):485-492. Hsueh CH, Hsu V, Zhao P, Zhang L, Giacomini KM, Huang SM. PMID: 28738449.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer. Biochemistry. 2017 07 11; 56(27):3475-3483. Stecula A, Schlessinger A, Giacomini KM, Sali A. PMID: 28661652.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    40. Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1. J Chem Inf Model. 2017 06 26; 57(6):1402-1413. Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM. PMID: 28562037.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    41. Transporters Involved in Metformin Pharmacokinetics and Treatment Response. J Pharm Sci. 2017 09; 106(9):2245-2250. Liang X, Giacomini KM. PMID: 28495567.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    42. The Effect of Uremic Solutes on the Organic Cation Transporter 2. J Pharm Sci. 2017 09; 106(9):2551-2557. Cheung KWK, Hsueh CH, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. PMID: 28483424.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). J Med Chem. 2017 04 13; 60(7):2685-2696. Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM. PMID: 28230985.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    44. Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis. Clin Pharmacol Ther. 2017 Jun; 101(6):763-772. Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorský M, Goswami S, Zaharenko L, Hougaard Christensen MM, Out M, Tavendale R, Kubo M, Hedderson MM, van der Heijden AA, Klimcáková L, Pirags V, Kooy A, Brøsen K, Klovins J, Semiz S, Tkác I, Stricker BH, Palmer C, 't Hart LM, Giacomini KM, Pearson ER. PMID: 27859023.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    45. Genomic Characterization of Metformin Hepatic Response. PLoS Genet. 2016 Nov; 12(11):e1006449. Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, Ahituv N. PMID: 27902686.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    46. Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine. Nat Rev Drug Discov. 2017 Jan; 16(1):1. Giacomini KM, Yee SW, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M. PMID: 27885282.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    47. The use of drug transporters as therapeutic targets. Clin Adv Hematol Oncol. 2016 Nov; 14(11):869-871. Giacomini KM. PMID: 27930637.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    48. A Molecular Basis for Innovation in Drug Excipients. Clin Pharmacol Ther. 2017 03; 101(3):320-323. Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini KM. PMID: 27557422.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    49. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clin Pharmacol Ther. 2016 Nov; 100(5):537-547. Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. PMID: 27415606.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    50. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clin Pharmacol Ther. 2016 Nov; 100(5):524-536. Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM. PMID: 27447836.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsCTClinical Trials
    51. LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. Bioorg Med Chem Lett. 2016 10 15; 26(20):5000-5006. Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. PMID: 27624080.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    52. Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3. Mol Pharm. 2016 09 06; 13(9):3130-40. Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. PMID: 27467266.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    53. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet. 2016 09; 48(9):1055-1059. Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkác I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER. PMID: 27500523.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    54. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Clin Pharmacol Ther. 2016 Nov; 100(5):423-426. Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M. PMID: 27256705.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    55. Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Eur J Nucl Med Mol Imaging. 2016 Jul; 43(7):1396. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Parisi MT, Shulkin BL, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. PMID: 27044383.
      View in: PubMed   Mentions:    Fields:    
    56. Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans. Front Pharmacol. 2016; 7:135. Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R. PMID: 27378919.
      View in: PubMed   Mentions:
    57. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016 06; 55(6):711-21. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. PMID: 26597253.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    58. A research roadmap for next-generation sequencing informatics. Sci Transl Med. 2016 04 20; 8(335):335ps10. Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, Mansfield E, Kass-Hout T. PMID: 27099173.
      View in: PubMed   Mentions: 8     Fields:    
    59. LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. Bioorg Med Chem Lett. 2016 06 01; 26(11):2616-2621. Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. PMID: 27106710.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    60. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet. 2016 Apr; 55(4):495-506. Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. PMID: 26507723.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    61. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J. 2017 03; 17(2):137-145. Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE. PMID: 26856248.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    62. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. Drug Metab Dispos. 2016 Mar; 44(3):356-64. Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM. PMID: 26700958.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    63. Unmet needs: Research helps regulators do their jobs. Sci Transl Med. 2015 Nov 25; 7(315):315ps22. Altman RB, Khuri N, Salit M, Giacomini KM. PMID: 26606966.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    64. Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 07; 12(12):4301-10. Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM. PMID: 26528626.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    65. Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Eur J Nucl Med Mol Imaging. 2016 Mar; 43(3):474-481. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. PMID: 26338179.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    66. Prediction and validation of enzyme and transporter off-targets for metformin. J Pharmacokinet Pharmacodyn. 2015 Oct; 42(5):463-75. Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. PMID: 26335661.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    67. SLC transporters as therapeutic targets: emerging opportunities. Nat Rev Drug Discov. 2015 Aug; 14(8):543-60. Lin L, Yee SW, Kim RB, Giacomini KM. PMID: 26111766.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    68. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Mol Pharmacol. 2015 Jul; 88(1):75-83. Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM. PMID: 25920679.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    69. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther. 2015 May; 97(5):518-25. Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. PMID: 25676789.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    70. Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma. Clin Cancer Res. 2015 Jun 15; 21(12):2715-21. DuBois SG, Groshen S, Park JR, Haas-Kogan DA, Yang X, Geier E, Chen E, Giacomini K, Weiss B, Cohn SL, Granger MM, Yanik GA, Hawkins R, Courtier J, Jackson H, Goodarzian F, Shimada H, Czarnecki S, Tsao-Wei D, Villablanca JG, Marachelian A, Matthay KK. PMID: 25695691.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    71. A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome. Pharmacogenet Genomics. 2015 Feb; 25(2):82-92. Dahlin A, Wittwer M, de la Cruz M, Woo JM, Bam R, Scharen-Guivel V, Flaherty J, Ray AS, Cihlar T, Gupta SK, Giacomini KM. PMID: 25485598.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    72. OCT1 in hepatic steatosis and thiamine disposition. Cell Cycle. 2015; 14(3):283-4. Chen L, Yee SW, Giacomini KM. PMID: 25590948.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    73. Genome-wide discovery of drug-dependent human liver regulatory elements. PLoS Genet. 2014 Oct; 10(10):e1004648. Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. PMID: 25275310.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    74. Metformin pharmacogenomics: current status and future directions. Diabetes. 2014 Aug; 63(8):2590-9. Pawlyk AC, Giacomini KM, McKeon C, Shuldiner AR, Florez JC. PMID: 25060887.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    75. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9983-8. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. PMID: 24961373.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    76. PharmGKB summary: very important pharmacogene information for SLC22A1. Pharmacogenet Genomics. 2014 Jun; 24(6):324-8. Goswami S, Gong L, Giacomini K, Altman RB, Klein TE. PMID: 24681965.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    77. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2014 Sep; 96(3):370-9. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. PMID: 24853734.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    78. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype. Clin Pharmacol Ther. 2014 Jun; 95(6):592-7. Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM. PMID: 24598717.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    79. Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations. Clin Pharmacokinet. 2014 Mar; 53(3):283-293. Hsu V, de L T Vieira M, Zhao P, Zhang L, Zheng JH, Nordmark A, Berglund EG, Giacomini KM, Huang SM. PMID: 24214317.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    80. Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther. 2013 Dec; 94(6):636-9. Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM. PMID: 24013810.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    81. A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol. 2014 Feb; 133(2):370-8. Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG. PMID: 23992748.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    82. Transporters in drug development and clinical pharmacology. Clin Pharmacol Ther. 2013 Jul; 94(1):3-9. Giacomini KM, Huang SM. PMID: 23778703.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    83. SLC classification: an update. Clin Pharmacol Ther. 2013 Jul; 94(1):19-23. Schlessinger A, Yee SW, Sali A, Giacomini KM. PMID: 23778706.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    84. International Transporter Consortium commentary on clinically important transporter polymorphisms. Clin Pharmacol Ther. 2013 Jul; 94(1):23-6. Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M. PMID: 23778707.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    85. Special Section on Pharmacogenomics: recent advances and future directions. J Hum Genet. 2013 Jun; 58(6):305. Mushiroda T, Giacomini KM, Kubo M. PMID: 23797326.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    86. Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. J Hum Genet. 2013 Jun; 58(6):353-61. Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C. PMID: 23677058.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    87. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep; 102(9):3451-7. Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. PMID: 23649425.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    88. Emerging transporters of clinical importance: an update from the International Transporter Consortium. Clin Pharmacol Ther. 2013 Jul; 94(1):52-63. Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L. PMID: 23588305.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    89. Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5480-5. Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM. PMID: 23509259.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    90. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm. 2013 Feb 04; 10(2):650-63. Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. PMID: 23268600.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    91. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem. 2013 Feb 14; 56(3):781-795. Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM. PMID: 23241029.
      View in: PubMed   Mentions: 32     Fields:    
    92. Molecular modeling and ligand docking for solute carrier (SLC) transporters. Curr Top Med Chem. 2013; 13(7):843-56. Schlessinger A, Khuri N, Giacomini KM, Sali A. PMID: 23578028.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    93. Renal transporters in drug development. Annu Rev Pharmacol Toxicol. 2013; 53:503-29. Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM. PMID: 23140242.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    94. The UCSF-FDA TransPortal: a public drug transporter database. Clin Pharmacol Ther. 2012 Nov; 92(5):545-6. Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini KM. PMID: 23085876.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    95. Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012 Nov; 22(11):820-7. Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE. PMID: 22722338.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    96. Highlights from the International Transporter Consortium second workshop. Clin Pharmacol Ther. 2012 Nov; 92(5):553-6. Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM. PMID: 23085880.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    97. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2013 Feb; 93(2):186-94. Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM. PMID: 23267855.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    98. Pharmacogenomics and patient care: one size does not fit all. Sci Transl Med. 2012 Sep 26; 4(153):153ps18. Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y. PMID: 23019654.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    99. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. Int J Mol Imaging. 2012; 2012:250834. Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK. PMID: 23050139.
      View in: PubMed   Mentions:
    100. High selectivity of the ?-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach. J Biol Chem. 2012 Nov 02; 287(45):37745-56. Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A. PMID: 22932902.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    101. Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong! Pharm Res. 2012 Sep; 29(9):2345-53. Smith DE, Rowland M, Giacomini KM, Amidon GL. PMID: 22814901.
      View in: PubMed   Mentions: 1     Fields:    
    102. The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet. 2012 Mar 28; 44(4):359-60. Yee SW, Chen L, Giacomini KM. PMID: 22456732.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    103. Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. Pharmacogenomics J. 2013 Apr; 13(2):110-20. Chen L, Hong C, Chen EC, Yee SW, Xu L, Almof EU, Wen C, Fujii K, Johns SJ, Stryke D, Ferrin TE, Simko J, Chen X, Costello JF, Giacomini KM. PMID: 22231567.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    104. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012 Jan; 22(1):1-8. Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV. PMID: 22147369.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    105. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin Cancer Res. 2012 Jan 15; 18(2):577-84. Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, McLeod HL, Goldberg RM, Schilsky RL, Kindler HL, Nakamura Y, Ratain MJ. PMID: 22142827.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    106. PharmGKB summary: methotrexate pathway. Pharmacogenet Genomics. 2011 Oct; 21(10):679-86. Mikkelsen TS, Thorn CF, Yang JJ, Ulrich CM, French D, Zaza G, Dunnenberger HM, Marsh S, McLeod HL, Giacomini K, Becker ML, Gaedigk R, Leeder JS, Kager L, Relling MV, Evans W, Klein TE, Altman RB. PMID: 21317831.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    107. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther. 2011 Nov; 90(5):674-84. Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM. PMID: 21956618.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    108. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15810-5. Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A. PMID: 21885739.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    109. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem. 2011 Jul 14; 54(13):4548-58. Kido Y, Matsson P, Giacomini KM. PMID: 21599003.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    110. Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters. Xenobiotica. 2011 Sep; 41(9):752-7. Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P. PMID: 21524191.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    111. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Clin Cancer Res. 2011 Apr 15; 17(8):2339-49. More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM. PMID: 21421857.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    112. Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. Pharmacogenomics J. 2012 Jun; 12(3):214-26. Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM. PMID: 21383772.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    113. Functional characterization of liver enhancers that regulate drug-associated transporters. Clin Pharmacol Ther. 2011 Apr; 89(4):571-8. Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N. PMID: 21368754.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    114. Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins. Mol Cancer Ther. 2011 Mar; 10(3):531-9. Minematsu T, Giacomini KM. PMID: 21252289.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    115. GABAA receptor open-state conformation determines non-competitive antagonist binding. Toxicol Appl Pharmacol. 2011 Feb 01; 250(3):221-8. Chen L, Xue L, Giacomini KM, Casida JE. PMID: 21111751.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    116. Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. Pharm Res. 2011 Mar; 28(3):610-25. Li S, Chen Y, Zhang S, More SS, Huang X, Giacomini KM. PMID: 21104302.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    117. Consequences of POR mutations and polymorphisms. Mol Cell Endocrinol. 2011 Apr 10; 336(1-2):174-9. Miller WL, Agrawal V, Sandee D, Tee MK, Huang N, Choi JH, Morrissey K, Giacomini KM. PMID: 21070833.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    118. Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro. Pharmacogenet Genomics. 2010 Nov; 20(11):677-86. Sandee D, Morrissey K, Agrawal V, Tam HK, Kramer MA, Tracy TS, Giacomini KM, Miller WL. PMID: 20940534.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    119. Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Pharmacogenet Genomics. 2010 Nov; 20(11):687-99. Chen L, Pawlikowski B, Schlessinger A, More SS, Stryke D, Johns SJ, Portman MA, Chen E, Ferrin TE, Sali A, Giacomini KM. PMID: 20859243.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    120. SLC19A1 pharmacogenomics summary. Pharmacogenet Genomics. 2010 Nov; 20(11):708-15. Yee SW, Gong L, Badagnani I, Giacomini KM, Klein TE, Altman RB. PMID: 20811316.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    121. Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase. Pharmacogenet Genomics. 2010 Oct; 20(10):611-8. Agrawal V, Choi JH, Giacomini KM, Miller WL. PMID: 20697309.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    122. Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F767-75. Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM. PMID: 20668102.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    123. Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function. J Pharmacol Exp Ther. 2010 Oct; 335(1):42-50. Chen L, Takizawa M, Chen E, Schlessinger A, Segenthelar J, Choi JH, Sali A, Kubo M, Nakamura S, Iwamoto Y, Iwasaki N, Giacomini KM. PMID: 20639304.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    124. Role of the copper transporter, CTR1, in platinum-induced ototoxicity. J Neurosci. 2010 Jul 14; 30(28):9500-9. More SS, Akil O, Ianculescu AG, Geier EG, Lustig LR, Giacomini KM. PMID: 20631178.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    125. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions. Pharmacogenomics J. 2011 Dec; 11(6):400-11. Ahlin G, Chen L, Lazorova L, Chen Y, Ianculescu AG, Davis RL, Giacomini KM, Artursson P. PMID: 20567254.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    126. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther. 2010 Apr; 9(4):1058-69. More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM. PMID: 20371711.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    127. Pharmacogenomics of membrane transporters: past, present and future. Pharmacogenomics. 2010 Apr; 11(4):475-9. Yee SW, Chen L, Giacomini KM. PMID: 20350125.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    128. Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine. Mol Biosyst. 2010 Aug; 6(8):1403-10. Ianculescu AG, Friesema EC, Visser TJ, Giacomini KM, Scanlan TS. PMID: 20358049.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    129. Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar; 9(3):215-36. Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L. PMID: 20190787.
      View in: PubMed   Mentions: 594     Fields:    Translation:HumansAnimals
    130. Comparison of human solute carriers. Protein Sci. 2010 Mar; 19(3):412-28. Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A. PMID: 20052679.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    131. The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA. Clin Pharmacol Ther. 2010 Jan; 87(1):32-6. Huang SM, Zhang L, Giacomini KM. PMID: 20019700.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    132. The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology. Clin Pharmacol Ther. 2010 Jan; 87(1):109-16. Kroetz DL, Yee SW, Giacomini KM. PMID: 19940846.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    133. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol. 2009 Dec 10; 27(35):5972-8. Treviño LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, Chan D, Sparreboom A, Giacomini KM, Pui CH, Evans WE, Relling MV. PMID: 19901119.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    134. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics. Clin Pharmacol Ther. 2010 Jan; 87(1):100-8. Picard N, Yee SW, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM, Marquet P. PMID: 19890249.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCellsCTClinical Trials
    135. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 2009 Oct; 10(10):1569-76. Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. PMID: 19842929.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    136. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009 Oct; 19(10):770-80. Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM. PMID: 19745787.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    137. A survey of integral alpha-helical membrane proteins. J Struct Funct Genomics. 2009 Dec; 10(4):269-80. Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A. PMID: 19760129.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    138. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One. 2009 Sep 09; 4(9):e6942. Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM. PMID: 19742321.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    139. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics. 2009 Jul; 19(7):497-504. Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. PMID: 19483665.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCellsCTClinical Trials
    140. The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. J Cardiovasc Pharmacol. 2009 Jul; 54(1):63-71. McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM. PMID: 19528813.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    141. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Pharmacogenomics J. 2009 Apr; 9(2):127-36. Chen Y, Teranishi K, Li S, Yee SW, Hesselson S, Stryke D, Johns SJ, Ferrin TE, Kwok P, Giacomini KM. PMID: 19172157.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    142. Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5). J Pharmacol Exp Ther. 2009 Apr; 329(1):262-71. Tahara H, Yee SW, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM. PMID: 19141711.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    143. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). J Pharmacol Exp Ther. 2009 Mar; 328(3):699-707. Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. PMID: 19098160.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    144. Identification and characterization of 3-iodothyronamine intracellular transport. Endocrinology. 2009 Apr; 150(4):1991-9. Ianculescu AG, Giacomini KM, Scanlan TS. PMID: 19074582.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    145. Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening. J Mol Biol. 2009 Jan 23; 385(3):820-30. Li M, Hays FA, Roe-Zurz Z, Vuong L, Kelly L, Ho CM, Robbins RM, Pieper U, O'Connell JD, Miercke LJ, Giacomini KM, Sali A, Stroud RM. PMID: 19061901.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    146. Genetic variation in human P450 oxidoreductase. Mol Cell Endocrinol. 2009 Mar 05; 300(1-2):180-4. Miller WL, Huang N, Agrawal V, Giacomini KM. PMID: 18930113.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    147. Genetic variation in human aquaporins and effects on phenotypes of water homeostasis. Hum Mutat. 2008 Sep; 29(9):1108-17. Sorani MD, Manley GT, Giacomini KM. PMID: 18470935.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    148. Pharm. D. pathways to biomedical research: the National Institutes of Health special conference on pharmacy research. Pharmacotherapy. 2008 Jul; 28(7):821-33. Figg WD, Chau CH, Okita R, Preusch P, Tracy TS, McLeod H, Reed M, Pieper J, Knoell D, Miller K, Speedie M, Blouin R, Kroboth P, Koda-Kimble MA, Taylor P, Cohen J, Giacomini K. PMID: 18576897.
      View in: PubMed   Mentions: 6     Fields:    
    149. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8902-7. Lovejoy KS, Todd RC, Zhang S, McCormick MS, D'Aquino JA, Reardon JT, Sancar A, Giacomini KM, Lippard SJ. PMID: 18579768.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    150. Creating and evaluating genetic tests predictive of drug response. Nat Rev Drug Discov. 2008 07; 7(7):568-74. Weiss ST, McLeod HL, Flockhart DA, Dolan ME, Benowitz NL, Johnson JA, Ratain MJ, Giacomini KM. PMID: 18587383.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    151. Genetic variation in drug transporters in ethnic populations. Clin Pharmacol Ther. 2008 Sep; 84(3):412-6. Cropp CD, Yee SW, Giacomini KM. PMID: 18528433.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    152. Novel variants in human Aquaporin-4 reduce cellular water permeability. Hum Mol Genet. 2008 Aug 01; 17(15):2379-89. Sorani MD, Zador Z, Hurowitz E, Yan D, Giacomini KM, Manley GT. PMID: 18511455.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    153. Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. J Neurotrauma. 2008 Apr; 25(4):291-8. Sorani MD, Morabito D, Rosenthal G, Giacomini KM, Manley GT. PMID: 18373479.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    154. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. J Pharmacol Exp Ther. 2008 Jun; 325(3):859-68. Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL. PMID: 18364470.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    155. Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1733-8. Huang N, Agrawal V, Giacomini KM, Miller WL. PMID: 18230729.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    156. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol. 2008 Apr; 73(4):1151-8. Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM. PMID: 18216183.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    157. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat Rev Drug Discov. 2007 Nov; 6(11):904-16. Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM. PMID: 17971785.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    158. Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenet Genomics. 2007 Sep; 17(9):773-82. Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM. PMID: 17700366.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    159. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther. 2008 Feb; 83(2):273-80. Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM. PMID: 17609683.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCTClinical Trials
    160. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther. 2008 Mar; 83(3):416-21. Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM. PMID: 17609685.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    161. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. J Pharmacol Exp Ther. 2007 Aug; 322(2):695-700. Chen Y, Zhang S, Sorani M, Giacomini KM. PMID: 17495125.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    162. Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing. Pharmacogenomics. 2007 May; 8(5):519. Altman RB, Benowitz N, Gurwitz D, Lunshof J, Relling M, Lamba J, Wieben E, Mooney S, Giacomini K, Weiss S, Johnson JA, McLeod H, Flockhart D, Weinshilboum R, Shuldiner AR, Roden D, Krauss RM, Ratain M. PMID: 17465717.
      View in: PubMed   Mentions: 3     Fields:    
    163. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest. 2007 May; 117(5):1422-31. Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM. PMID: 17476361.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    164. When good drugs go bad. Nature. 2007 Apr 26; 446(7139):975-7. Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y. PMID: 17460642.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    165. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther. 2007 Mar; 81(3):328-45. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I. PMID: 17339863.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    166. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006 Nov 21; 145(10):749-57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, Krauss RM, McLeod HL, Ratain MJ, Relling MV, Ring HZ, Shuldiner AR, Weinshilboum RM, Weiss ST. PMID: 17116919.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    167. Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 01; 66(17):8847-57. Zhang S, Lovejoy KS, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Chen Y, Komori T, Gray JW, Chen X, Lippard SJ, Giacomini KM. PMID: 16951202.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    168. Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Mol Pharmacol. 2006 Nov; 70(5):1602-11. Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM. PMID: 16931768.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    169. Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. J Biol Chem. 2006 Sep 08; 281(36):26675-82. Owen RP, Badagnani I, Giacomini KM. PMID: 16840788.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    170. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug; 318(2):521-9. Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. PMID: 16702441.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    171. PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):1-2. Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL. PMID: 16507877.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    172. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Pharmacol Rev. 2006 Mar; 58(1):3-4. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PMID: 16507878.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    173. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):5-6. Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PMID: 16507879.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    174. Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. J Pharm Sci. 2006 Jan; 95(1):25-36. Fujita T, Urban TJ, Leabman MK, Fujita K, Giacomini KM. PMID: 16307453.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    175. Functional genomics of membrane transporters in human populations. Genome Res. 2006 Feb; 16(2):223-30. Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM. PMID: 16354753.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    176. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F905-12. Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM. PMID: 16291576.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    177. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. Drug Metab Dispos. 2006 Jan; 34(1):12-5. Owen RP, Lagpacan LL, Taylor TR, De La Cruz M, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. PMID: 16214850.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    178. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005 Apr; 15(4):201-9. Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM. PMID: 15864112.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    179. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenet Genomics. 2005 Feb; 15(2):83-90. Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. PMID: 15861032.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    180. Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease. Inflamm Bowel Dis. 2005 Jan; 11(1):78-9. Urban TJ, Giacomini KM, Risch N. PMID: 15674120.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    181. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005; 5(3):157-65. Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. PMID: 15738947.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    182. Enhancing data sharing in collaborative research projects with DASH. Pac Symp Biocomput. 2005; 260-71. Ferrin TE, Huang CC, Greenblatt DM, Stryke D, Giacomini KM, Morris JH. PMID: 15759632.
      View in: PubMed   Mentions:    Fields:    
    183. PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1. Pharmacol Rev. 2004 Jun; 56(2):161. Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM. PMID: 15169925.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    184. Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. Mol Pharmacol. 2004 Mar; 65(3):512-9. Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. PMID: 14978229.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    185. Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. Eur J Pharmacol. 2003 Oct 31; 479(1-3):269-81. Mangravite LM, Badagnani I, Giacomini KM. PMID: 14612157.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    186. Estimating the contribution of genes and environment to variation in renal drug clearance. Pharmacogenetics. 2003 Sep; 13(9):581-4. Leabman MK, Giacomini KM. PMID: 12972957.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    187. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics. 2003 Aug; 13(8):481-94. Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG. PMID: 12893986.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    188. PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2). Pharmacol Rev. 2003 Sep; 55(3):399. Leabman MK, Huang CC, Stryke D, Johns SJ, Kawamoto M, Ferrin TE, DeYoung J, Taylor TR, De La Cruz M, Herskowitz I, Giacomini KM. PMID: 12869664.
      View in: PubMed   Mentions: 3     Fields:    
    189. The concentrative nucleoside transporter family, SLC28. Pflugers Arch. 2004 Feb; 447(5):728-34. Gray JH, Owen RP, Giacomini KM. PMID: 12856181.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimals
    190. Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1. Pharmacogenetics. 2003 May; 13(5):297-301. Osato DH, Huang CC, Kawamoto M, Johns SJ, Stryke D, Wang J, Ferrin TE, Herskowitz I, Giacomini KM. PMID: 12724623.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    191. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5902-7. Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM. PMID: 12719534.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    192. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5896-901. Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM. PMID: 12719533.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    193. Sorting of rat SPNT in renal epithelium is independent of N-glycosylation. Pharm Res. 2003 Feb; 20(2):319-23. Mangravite LM, Giacomini KM. PMID: 12636174.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    194. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am J Physiol Renal Physiol. 2003 May; 284(5):F902-10. Mangravite LM, Xiao G, Giacomini KM. PMID: 12527552.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    195. SNP analysis and presentation in the Pharmacogenetics of Membrane Transporters Project. Pac Symp Biocomput. 2003; 535-47. Stryke D, Huang CC, Kawamoto M, Johns SJ, Carlson EJ, Deyoung JA, Leabman MK, Herskowitz I, Giacomini KM, Ferrin TE. PMID: 12603056.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    196. Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. Am J Physiol Renal Physiol. 2002 Aug; 283(2):F344-9. Gerstin KM, Dresser MJ, Giacomini KM. PMID: 12110519.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    197. Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharm Res. 2002 Aug; 19(8):1244-7. Dresser MJ, Xiao G, Leabman MK, Gray AT, Giacomini KM. PMID: 12240953.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    198. Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition. Biochemistry. 2002 Jul 16; 41(28):8941-7. Feng B, Shu Y, Giacomini KM. PMID: 12102636.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    199. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 2002 Jul; 12(5):395-405. Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Clark AG, Herskowitz I, Giacomini KM. PMID: 12142729.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    200. Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. J Pharmacol Exp Ther. 2001 Oct; 299(1):392-8. Shu Y, Bello CL, Mangravite LM, Feng B, Giacomini KM. PMID: 11561104.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    201. Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3. Biochemistry. 2001 May 08; 40(18):5511-20. Feng B, Dresser MJ, Shu Y, Johns SJ, Giacomini KM. PMID: 11331016.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    202. Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line. Am J Physiol Renal Physiol. 2001 May; 280(5):F879-85. Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM. PMID: 11292631.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    203. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J Pharm Sci. 2001 Apr; 90(4):397-421. Dresser MJ, Leabman MK, Giacomini KM. PMID: 11170032.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    204. Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. Nat Genet. 2001 Apr; 27(4):435-8. Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB. PMID: 11279528.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    205. A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans. Mol Pharmacol. 2001 Feb; 59(2):339-48. Xiao G, Wang J, Tangen T, Giacomini KM. PMID: 11160871.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    206. Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes. Drug Metab Dispos. 2000 Sep; 28(9):1135-40. Dresser MJ, Gerstin KM, Gray AT, Loo DD, Giacomini KM. PMID: 10950861.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    207. Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine. Pharm Res. 2000 Aug; 17(8):906-10. Gerstin KM, Dresser MJ, Wang J, Giacomini KM. PMID: 11028933.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    208. Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar; 28(3):329-34. Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM. PMID: 10681378.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    209. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1). J Pharmacol Exp Ther. 2000 Mar; 292(3):1146-52. Dresser MJ, Gray AT, Giacomini KM. PMID: 10688634.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    210. Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system. J Pharmacol Exp Ther. 1999 Jun; 289(3):1487-91. Schaner ME, Wang J, Zhang L, Su SF, Gerstin KM, Giacomini KM. PMID: 10336543.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    211. The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1. J Pharmacol Exp Ther. 1999 Mar; 288(3):1192-8. Zhang L, Gorset W, Dresser MJ, Giacomini KM. PMID: 10027858.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    212. Characterization of a bioengineered chimeric Na+-nucleoside transporter. Mol Pharmacol. 1999 Feb; 55(2):234-40. Wang J, Giacomini KM. PMID: 9927613.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    213. Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter. J Biol Chem. 1999 Jan 22; 274(4):2298-302. Wang J, Giacomini KM. PMID: 9890994.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    214. Molecular and functional characteristics of cloned human organic cation transporters. Pharm Biotechnol. 1999; 12:441-69. Dresser MJ, Zhang L, Giacomini KM. PMID: 10742984.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    215. Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul; 286(1):354-61. Zhang L, Schaner ME, Giacomini KM. PMID: 9655880.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    216. Nucleoside transport in isolated human and rhesus choroid plexus tissue slices. Pharm Res. 1998 Jul; 15(7):1145-7. Washington CB, Giacomini KM, Brett CM. PMID: 9688074.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    217. Nicotine transport in a human choriocarcinoma cell line (JAR). J Pharm Sci. 1998 Jun; 87(6):702-6. Zevin S, Schaner ME, Giacomini KM. PMID: 9607946.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    218. Molecular cloning and functional expression of a rabbit renal organic cation transporter. Biochim Biophys Acta. 1998 Feb 02; 1369(1):1-6. Terashita S, Dresser MJ, Zhang L, Gray AT, Yost SC, Giacomini KM. PMID: 9528667.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    219. Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol. 1998; 38:431-60. Zhang L, Brett CM, Giacomini KM. PMID: 9597162.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    220. Membrane transporters in drug disposition. J Pharmacokinet Biopharm. 1997 Dec; 25(6):731-41. Giacomini KM. PMID: 9697080.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    221. Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am J Physiol. 1997 12; 273(6):F1058-65. Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM. PMID: 9435697.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    222. Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters. J Biol Chem. 1997 Nov 14; 272(46):28845-8. Wang J, Giacomini KM. PMID: 9360950.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    223. Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Biochim Biophys Acta. 1997 Nov 13; 1330(1):94-102. Ramanathan VK, Brett CM, Giacomini KM. PMID: 9375816.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    224. Functional and molecular characteristics of Na(+)-dependent nucleoside transporters. Pharm Res. 1997 Nov; 14(11):1524-32. Wang J, Schaner ME, Thomassen S, Su SF, Piquette-Miller M, Giacomini KM. PMID: 9434270.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    225. Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa). Pharm Res. 1997 Oct; 14(10):1316-21. Schaner ME, Wang J, Zevin S, Gerstin KM, Giacomini KM. PMID: 9358542.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    226. Characterization of guanidine transport in human renal brush border membranes. Pharm Res. 1997 Jul; 14(7):936-41. Chun JK, Zhang L, Piquette-Miller M, Lau E, Tong LQ, Giacomini KM. PMID: 9244153.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    227. Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). J Biol Chem. 1997 Jun 27; 272(26):16548-54. Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM. PMID: 9195965.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    228. Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun; 51(6):913-21. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM. PMID: 9187257.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    229. Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes. J Pharm Sci. 1997 Jun; 86(6):753-5. Chun JK, Piquette-Miller M, Zhang L, Giacomini KM. PMID: 9188060.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    230. Taurine transport in cultured choroid plexus. Pharm Res. 1997 Apr; 14(4):406-9. Ramanathan VK, Chung SJ, Giacomini KM, Brett CM. PMID: 9144722.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    231. Guanidine transport in a human choriocarcinoma cell line (JAR). Pharm Res. 1997 Apr; 14(4):401-5. Zevin S, Schaner ME, Illsley NP, Giacomini KM. PMID: 9144721.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    232. Mechanisms of 5-fluorouracil (5-FU) transport in isolated rabbit choroid plexus tissue slices. Pharm Res. 1996 Aug; 13(8):1276-8. Washington CB, Giacomini KM. PMID: 8865326.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    233. Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport. Pharm Res. 1996 Jun; 13(6):952-6. Ramanathan VK, Hui AC, Brett CM, Giacomini KM. PMID: 8792439.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    234. Saturable disposition of taurine in the rat cerebrospinal fluid. J Pharmacol Exp Ther. 1996 Feb; 276(2):676-82. Chung SJ, Ramanathan VK, Brett CM, Giacomini KM. PMID: 8632336.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    235. Isolated renal brush border and basolateral membrane vesicles and cultured renal cells. Pharm Biotechnol. 1996; 8:193-210. Gutierrez MM, Brett CM, Giacomini KM. PMID: 8791811.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    236. Methods of study drug transport in isolated choroid plexus tissue and cultured cells. Pharm Biotechnol. 1996; 8:259-83. Washington CB, Giacomini KM, Brett CM. PMID: 8791814.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    237. Mechanisms of nucleobase transport in rabbit choroid plexus. Evidence for a Na(+)-dependent nucleobase transporter with broad substrate selectivity. J Biol Chem. 1995 Sep 29; 270(39):22816-9. Washington CB, Giacomini KM. PMID: 7559412.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    238. The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus. J Pharmacol Exp Ther. 1995 Jul; 274(1):110-4. Washington CB, Brett CM, Wu X, Giacomini KM. PMID: 7616386.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    239. The effects of modulation of calcium influx through the voltage-sensitive calcium channel on cardiomyocyte hypertrophy. J Mol Cell Cardiol. 1995 Mar; 27(3):917-25. Lubic SP, Giacomini KM, Giacomini JC. PMID: 7602609.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    240. Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes. Biochem Pharmacol. 1994 Dec 16; 48(12):2251-3. Gutierrez MM, Giacomini KM. PMID: 7811307.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    241. Increased 1,4-dihydropyridine binding sites in serum-stimulated cardiomyocyte hypertrophy. J Pharmacol Exp Ther. 1994 Aug; 270(2):697-701. Lubic SP, Giacomini KM, Giacomini JC. PMID: 8071861.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    242. Expression of the choroid plexus sodium-nucleoside cotransporter (N3) in Xenopus laevis oocytes. Biochem Pharmacol. 1994 Jul 19; 48(2):432-4. Wu X, Giacomini KM. PMID: 7519856.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    243. Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus. Biochim Biophys Acta. 1994 Jul 13; 1193(1):10-6. Chung SJ, Ramanathan V, Giacomini KM, Brett CM. PMID: 8038178.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    244. Expression of a renal Na(+)-nucleoside cotransport system (N2) in Xenopus laevis oocytes. Pflugers Arch. 1994 Jun; 427(3-4):381-3. Giacomini KM, Markovich D, Werner A, Biber J, Wu X, Murer H. PMID: 7521031.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    245. Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit. Biochim Biophys Acta. 1994 Apr 20; 1191(1):190-6. Wu X, Gutierrez MM, Giacomini KM. PMID: 8155674.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    246. Effect of phenylisothiocyanate on organic cation transport in opossum kidney cells. J Pharmacol Exp Ther. 1994 Apr; 269(1):204-8. Ott RJ, Chan JK, Ramanathan VK, Hui AC, Giacomini KM. PMID: 8169826.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    247. Stereoselective interactions of organic cations with the organic cation transporter in OK cells. Pharm Res. 1993 Aug; 10(8):1169-73. Ott RJ, Giacomini KM. PMID: 8415403.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    248. Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney. Biochim Biophys Acta. 1993 Jul 04; 1149(2):202-8. Gutierrez MM, Giacomini KM. PMID: 8323939.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    249. Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine. Drug Metab Dispos. 1993 Jul-Aug; 21(4):587-97. Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM. PMID: 8104117.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    250. Formycin B elimination from the cerebrospinal fluid of the rat. Pharm Res. 1993 Apr; 10(4):611-5. Wu X, Hui AC, Giacomini KM. PMID: 8483848.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    251. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Pharm Res. 1993 Mar; 10(3):423-6. Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM. PMID: 8464817.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    252. Caring for the community. Caring. 1993; 1(12):38-42. Hayes K, Morgan B, Giacomini K, Dockal S.
    253. Beta-adrenergic blockers as cardioprotective agents. Am J Cardiol. 1992 Dec 21; 70(21):2I-6I. Frishman WH. PMID: 1361718.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    254. Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction. Am J Physiol. 1992 Oct; 263(4 Pt 1):L446-53. Chang SW, Dutton D, Wang HL, He LS, Stearns R, Hui A, Giacomini KM, Ortiz de Montellano P, Voelkel NF. PMID: 1415722.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    255. Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. J Biol Chem. 1992 May 05; 267(13):8813-8. Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM. PMID: 1315741.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    256. Nucleoside transport in brush border membrane vesicles from human kidney. Biochim Biophys Acta. 1992 Mar 23; 1105(1):1-9. Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM. PMID: 1567888.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    257. Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells. J Biol Chem. 1992 Jan 05; 267(1):133-9. Ott RJ, Hui AC, Giacomini KM. PMID: 1730580.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    258. Organic cation transport in human renal brush-border membrane vesicles. Am J Physiol. 1991 Sep; 261(3 Pt 2):F443-51. Ott RJ, Hui AC, Yuan G, Giacomini KM. PMID: 1832266.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    259. Transport of organic cations by a renal epithelial cell line (OK). J Biol Chem. 1991 May 15; 266(14):8978-86. Yuan G, Ott RJ, Salgado C, Giacomini KM. PMID: 1827442.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    260. Preparation of brush border membrane vesicles from bovine choroid plexus. J Pharmacol Methods. 1991 May; 25(3):215-27. Whittico MT, Hui AC, Giacomini KM. PMID: 1647471.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    261. Effect of probenecid on the pharmacokinetics and pharmacodynamics of procainamide. J Clin Pharmacol. 1991 May; 31(5):429-32. Lam YW, Boyd RA, Chin SK, Chang D, Giacomini KM. PMID: 2050827.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    262. Interactions of quinidine and quinine and (+)- and (-)-pindolol with the organic cation/proton antiporter in renal brush border membrane vesicles. Biochem Pharmacol. 1991 Jan 01; 41(1):142-5. Ott RJ, Hui AC, Wong FM, Hsyu PH, Giacomini KM. PMID: 1824749.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    263. Cimetidine transport in isolated brush border membrane vesicles from bovine choroid plexus. J Pharmacol Exp Ther. 1990 Nov; 255(2):615-23. Whittico MT, Gang YA, Giacomini KM. PMID: 2173750.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    264. Mechanisms of interactions between organic anions and the organic cation transporter in renal brush border membrane vesicles. Biochem Pharmacol. 1990 Aug 01; 40(3):659-61. Ott RJ, Hai AC, Giacomini KM. PMID: 2143380.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    265. Computer-guided laser for neurosurgery. Ann Chir Gynaecol. 1990; 79(4):192-6. Koivukangas J, Louhisalmi Y. PMID: 2102636.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    266. The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose. Clin Pharmacol Ther. 1989 Oct; 46(4):408-19. Boyd RA, Chin SK, Don-Pedro O, Verotta D, Sheiner LB, Williams RL, Giacomini KM. PMID: 2791444.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    267. High-performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. II. Studies with atenolol. J Chromatogr. 1989 Apr 14; 489(2):438-45. Chin SK, Hui AC, Giacomini KM. PMID: 2568994.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    268. The effect of probenecid on the renal elimination of cimetidine. Clin Pharmacol Ther. 1989 Apr; 45(4):444-52. Gisclon LG, Boyd RA, Williams RL, Giacomini KM. PMID: 2702802.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    269. The pharmacokinetics of the enantiomers of atenolol. Clin Pharmacol Ther. 1989 Apr; 45(4):403-10. Boyd RA, Chin SK, Don-Pedro O, Williams RL, Giacomini KM. PMID: 2702798.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    270. Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium. J Cardiovasc Pharmacol. 1988 Dec; 12(6):650-7. Boyd RA, Giacomini JC, Giacomini KM. PMID: 2467082.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    271. Cimetidine elimination from the cerebrospinal fluid of the rat. Pharm Res. 1988 Oct; 5(10):628-33. Whittico MT, Giacomini KM. PMID: 3244614.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    272. Renal transport of drugs: an overview of methodology with application to cimetidine. Pharm Res. 1988 Aug; 5(8):465-71. Giacomini KM, Hsyu PH, Gisclon LG. PMID: 3072557.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    273. The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles. Drug Metab Dispos. 1988 May-Jun; 16(3):503-5. Hsyu PH, Wong FM, Giacomini KM. PMID: 2900748.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    274. Stereoselective binding of disopyramide to plasma proteins. Pharm Res. 1988 May; 5(5):316-8. Valdivieso L, Giacomini KM, Nelson WL, Pershe R, Blaschke TF. PMID: 3244643.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    275. Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney. Drug Metab Dispos. 1988 Mar-Apr; 16(2):331-2. Gisclon LG, Giacomini KM. PMID: 2898357.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    276. Interactions of organic anions with the organic cation transporter in renal BBMV. Am J Physiol. 1988 Jan; 254(1 Pt 2):F56-61. Hsyu PH, Gisclon LG, Hui AC, Giacomini KM. PMID: 2962517.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    277. Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium. J Pharmacol Exp Ther. 1987 Oct; 243(1):118-25. Boyd RA, Giacomini JC, Wong FM, Nelson WL, Giacomini KM. PMID: 2822893.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    278. Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney. Am J Physiol. 1987 Jul; 253(1 Pt 2):F141-50. Gisclon L, Wong FM, Giacomini KM. PMID: 3605344.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    279. Essential tyrosine residues in transport of organic cations in renal BBMV. Am J Physiol. 1987 Jun; 252(6 Pt 2):F1065-72. Hsyu PH, Giacomini KM. PMID: 2954470.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    280. The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange. J Biol Chem. 1987 Mar 25; 262(9):3964-8. Hsyu PH, Giacomini KM. PMID: 2951380.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    281. The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site. J Mol Cell Cardiol. 1986 Sep; 18(9):963-74. Zobrist RH, Giacomini KM, Nelson WL, Giacomini JC. PMID: 3783730.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    282. Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil. J Med Chem. 1986 Sep; 29(9):1789-92. Theodore LJ, Nelson WL, Zobrist RH, Giacomini KM, Giacomini JC. PMID: 2427721.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    283. Posttraumatic complications and inflammatory mediators. Arch Surg. 1986 Aug; 121(8):886-90. Nuytinck JK, Goris JA, Redl H, Schlag G, van Munster PJ. PMID: 3488050.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    284. In vivo interaction of the enantiomers of disopyramide in human subjects. J Pharmacokinet Biopharm. 1986 Aug; 14(4):335-56. Giacomini KM, Nelson WL, Pershe RA, Valdivieso L, Turner-Tamiyasu K, Blaschke TF. PMID: 3772736.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    285. High performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. I: Studies with pindolol. J Pharm Sci. 1986 Jun; 75(6):601-5. Hsyu PH, Giacomini KM. PMID: 2874209.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    286. Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel. Biochem Pharmacol. 1986 Feb 15; 35(4):716-8. Giacomini JC, Nelson WL, Wong FM, Boyd R, Zobrist RH, Giacomini KM. PMID: 2868731.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    287. Stereoselective renal clearance of pindolol in humans. J Clin Invest. 1985 Nov; 76(5):1720-6. Hsyu PH, Giacomini KM. PMID: 4056049.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    288. Electrophysiology of the enantiomers of disopyramide in dogs. J Cardiovasc Pharmacol. 1985 Sep-Oct; 7(5):884-90. Giacomini JC, Giacomini KM, Nelson WL, Harrison DC, Blaschke TF. PMID: 2413296.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    289. The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits. J Cardiovasc Pharmacol. 1985 May-Jun; 7(3):469-75. Giacomini JC, Nelson WL, Theodore L, Wong FM, Rood D, Giacomini KM. PMID: 2410676.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    290. Verapamil interacts stereoselectively with the muscarinic receptor. Pharm Res. 1985 Mar; 2(2):94-5. Giacomini JC, Zobrist RH, Dave B, Giacomini KM. PMID: 24272619.
      View in: PubMed   Mentions:    Fields:    
    291. Decreased binding of verapamil to plasma proteins in patients with liver disease. J Cardiovasc Pharmacol. 1984 Sep-Oct; 6(5):924-8. Giacomini KM, Massoud N, Wong FM, Giacomini JC. PMID: 6209501.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    292. Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration. Pharm Res. 1984 Jul; 1(4):179-81. Giacomini KM, Wong FM, Tozer TN. PMID: 24277288.
      View in: PubMed   Mentions: 5     Fields:    
    293. High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma. J Chromatogr. 1984 May 11; 307(2):410-5. Smith GA, Giacomini KM, Smith CT, Gregory PB, Robinson WS, Merigan TC, Blaschke TF. PMID: 6203924.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    294. Effect of concentration-dependent binding to plasma proteins on the pharmacokinetics and pharmacodynamics of disopyramide. Clin Pharmacokinet. 1984 Jan; 9 Suppl 1:42-8. Giacomini KM, Blaschke TF. PMID: 6705426.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    295. Amitriptyline disposition in young and elderly normal men. Clin Pharmacol Ther. 1983 Mar; 33(3):360-6. Schulz P, Turner-Tamiyasu K, Smith G, Giacomini KM, Blaschke TF. PMID: 6825390.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    296. Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man. Eur J Clin Pharmacol. 1983; 25(2):211-4. Schulz P, Giacomini KM, Luttrell S, Turner-Tamiyasu K, Blaschke TF. PMID: 6628503.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    297. Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin. Ther Drug Monit. 1983; 5(4):497-9. Schulz P, Abang A, Giacomini JC, Blaschke TF, Giacomini KM. PMID: 6659020.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    298. Calculation of drug concentration in plasma after equilibrium dialysis. Br J Clin Pharmacol. 1982 Nov; 14(5):752-4. Giacomini KM, Abang A, Blaschke TF. PMID: 7138760.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    299. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study. Circulation. 1982 Aug; 66(2):447-53. Pollick C, Giacomini KM, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, Popp RL. PMID: 7094252.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    300. High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood. J Pharm Sci. 1982 May; 71(5):581-3. Smith GA, Schulz P, Giacomini KM, Blaschke TF. PMID: 7097507.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    301. Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography. J Chromatogr. 1982 Feb 12; 227(2):510-5. Swezey SF, Giacomini KM, Abang A, Brass C, Stevens DA, Blaschke TF. PMID: 6277970.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    302. The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide. J Pharmacokinet Biopharm. 1982 Feb; 10(1):1-14. Giacomini KM, Swezey SE, Turner-Tamiyasu K, Blaschke TF. PMID: 7069575.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    303. Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide. J Med Chem. 1981 May; 24(5):614-7. Nelson WL, Sneed CK, Giacomini KM, Giacomini JC, Stauss J, Blaschke TF, Cox BM. PMID: 7241519.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    304. Evaluation of methods for producing renal dysfunction in rats. J Pharm Sci. 1981 Feb; 70(2):117-21. Giacomini KM, Roberts SM, Levy G. PMID: 7205211.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    305. Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins. Biochem Pharmacol. 1980 Dec; 29(24):3337-40. Giacomini KM, Giacomini JC, Blaschke TF. PMID: 7213407.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    306. The stereoselective disposition of disopyramide in the dog. J Cardiovasc Pharmacol. 1980 Nov-Dec; 2(6):825-32. Giacomini KM, Giacomini JC, Swezey SE, Harrison DC, Nelson WL, Burke TR, Blaschke TF. PMID: 6160331.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    307. Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum. Life Sci. 1980 Sep 29; 27(13):1191-7. Giacomini KM, Cox BM, Blaschke TF. PMID: 7421405.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    308. Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt. Clin Pharmacol Ther. 1980 Sep; 28(3):417-24. Giacomini KM, Giacomini JC, Gibson TP, Levy G. PMID: 7408401.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    309. Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma. Life Sci. 1980 Sep 01; 27(9):771-80. Giacomini KM, Swezey SE, Giacomini JC, Blaschke TF. PMID: 7412503.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    310. Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs. J Pharm Sci. 1980 Jul; 69(7):786-9. Giacomini KM, Nakeeb SM, Levy G. PMID: 7391940.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    311. Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient. Clin Pharmacol Ther. 1980 May; 27(5):665-70. Gibson TP, Giacomini KM, Briggs WA, Whitman W, Levy G. PMID: 7371364.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    312. Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients. Clin Pharmacol Ther. 1980 Apr; 27(4):508-14. Giacomini KM, Gibson TP, Levy G. PMID: 7357810.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    313. Phenylalanine metabolism in uremic and normal man. Kidney Int. 1978 Aug; 14(2):169-79. Jones MR, Kopple JD, Swendseid ME. PMID: 357810.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    314. Rational aspirin dosage regimens. Clin Pharmacol Ther. 1978 Mar; 23(3):247-52. Levy G, Giacomini KM. PMID: 627128.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    315. Plasma protein binding of d-propoxyphene in normal subjects and anephric patients. J Clin Pharmacol. 1978 Feb-Mar; 18(2-3):106-9. Giacomini KM, Gibson TP, Levy G. PMID: 624774.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    316. A Convenient Method for Repetitive Blood Sampling in the Dog. J. Pharmacol. Meth. 1978; (1):259-261. Soles C, Giacomini KM, Roberts SM, Giacomini JC. Soles C, Giacomini KM, Roberts SM, Giacomini JC.
    317. [Diagnosis of toxoplasmosis by indirect hemagglutination. II. Value of mixed total antigen fixation in the presence of glutaraldehyde in the early diagnosis of the disease]. Biomedicine. 1976 Jul; 25(6):212-4. Senet JM, Robert R, Mauras G. PMID: 822893.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
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