Kathy Giacomini, PhD

Title(s)Dean-School of Phrmcy/AssocVC, Dean's Office
SchoolSchool of Pharmacy
Address513 Parnassus Avenue, MSB, #126
San Francisco CA 94143
ORCID ORCID Icon0000-0001-8041-5430 Additional info
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    Other Positions
    Title(s)Co-Director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation

    Collapse Biography 
    Collapse Awards and Honors
    American Association of Pharmaceutical Scientists2021Distinguished Pharmaceutical Scientist Award
    American Society of Pharmacology and Experimental Therapeutics2020B.B. Brodie Award
    American Association of Colleges of Pharmacy2018Volwiler Research Achievement Award
    Swedish Academy of Pharmaceutical Scientists2011Scheele Award
    Therapeutic Frontiers Lecture Award2010Therapeutic Frontiers Lecture Award
    Postdoctoral Scholars Association, University of California, San Francisco2009Outstanding Mentor Award
    American Society for Clinical Pharmacology and Therapeutics2009Rawls-Palmer Progress in Medicine Award
    Japan Society for the Promotion of Science2008Invitation Fellowship Program for Research in Japan
    Academy of Pharmaceutical Sciences and Technology, Japan2007International Woman Scientist Award
    Pharmaceutical Sciences World Congress2007Research Achievement Award
    National Academy of Medicine2006Elected Member
    American Association of Pharmaceutical Scientists2006Distinguished Scientist Award in Drug Metabolism
    American Association of Colleges of Pharmacy2005Paul Dawson Biotechnology Award
    State University of New York at Buffalo2002Distinguished Gerhard Levy Lectureship
    U.S. Food and Drug Administration2002Distinguished Bill Abram's Lectureship
    University of California, San Francisco2002Honored Celebrating Women Faculty
    University of Kentucky2000Guttman Lecturer
    International Pharmaceutical Federation (FIP)1999Scientist of the Year
    University of California, San Francisco1999Recognition Award for Distinguished Achievement of a Filipino at UCSF
    University of California, San Francisco1997Chancellor's Award for the Advancement of Women
    University of California, San Francisco1994Martin Luther King, Jr. Award for the Advancement of Minorities
    National Institutes of Health1992Fogarty International Fellowship
    American Society for Clinical Pharmacology and Therapeutics1990Leon Goldberg Young Investigator Award

    Collapse Overview 
    Collapse Overview
    The Giacomini research group focuses on expanding our understanding of membrane transporters. Membrane transporters are of great biological and pharmacological importance, as they play a major role in human physiology and in drug disposition and response. Major questions addressed in the laboratory include: What is the function of orphan membrane transporters? What is the in vivo role of membrane transporters in the disposition of endogenous solutes as well as in drug disposition and response? How does genetic variation in membrane transporters affect solute disposition, human disease and drug response? What are the structural determinants of specificity?

    Dr. Kathy Giacomini is leading an effort to deorphan transporters in the Solute Carrier 22 Family, and to determine the clinical implications of specific genetic variants in membrane transporters. Research ventures, ranging from basic discovery to clinical studies, have demonstrated that common variants of membrane transporters contribute to differences in drug response in ethnically diverse populations. Ultimately, these studies will increase our knowledge of the genetic basis underlying drug response and will contribute to advancing the era of personalized medicine. Furthermore, our studies will elucidate the genetic mechanisms of decreased drug response and, ultimately, contribute to improving drug design for safe and effective treatments of subgroups of patients who do not respond to standard treatments.

    Research in the laboratory focuses on drugs used in the treatment of diseases associated with metabolic syndrome. We are particularly interested in identifying the genetic determinants of the anti-diabetic drugs, metformin and sulfonylureas, highly prescribed drugs. In particular, our research focuses on discovering functional genetic variants that underlie variation in response to these drugs in large ethnically diverse patient populations. Finally, Kathy Giacomini and her collaborator, Russ Altman of Stanford University are the Co-PIs of the UCSF–Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) funded by the Food and Drug Administration (FDA). Established in 2014 and renewed in 2021, the UCSF-Stanford CERSI aims to advance the field of regulatory sciences and improve the development and evaluation of diagnostics, therapeutics and medical devices. The UCSF-Stanford CERSI is the first FDA funded CERSI on the west coast and seeks to address key challenges related to education and research that will advance the discovery and development of medical products.

    DEI Statement: As a biracial woman faculty member with ancestries in the Philippines and Europe, I am deeply committed to issues of diversity, equity and inclusion. I am a strong advocate for graduate students and postdocs of diverse ancestries and particularly under-represented minorities (URM). In my career, I have been the academic advisor for students who are URMs and who now have vibrant careers in academia and industry. My mentoring style is very personal. That is, I tailor my advising of each trainee to their career goals and aspirations, helping them to achieve these goals. On the recommendation of my students, I have institute diversity presentations as part of our regularly scheduled research group meetings. We begin each research group meeting with a diversity presentation, given by an individual group member, who describes some aspect of their cultural background. These are fun and educational and build an inclusive and welcoming environment in my laboratory. As the co-PI of the UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation, CERSI, we established a CERSI Diversity Scholars Program in 2021 and have now made four awards to the scholars (students or postdocs) at UCSF from diverse ethnic backgrounds. My personal goal is to promote diversity, equity and inclusion at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Characterizing the physiological and pharmacological roles of SLC22A24
    NIH R01GM139875Apr 1, 2021 - Mar 31, 2025
    Role: Principal Investigator
    UCSF-Stanford Center of Excellence in Regulatory Science and Innovation
    NIH U01FD005978Sep 15, 2016 - Aug 31, 2023
    Role: Principal Investigator
    Discovery of Pharmacogenomic Biomarkers for OATP1B1 and OATP1B3
    NIH R01GM117163Sep 25, 2015 - Jul 31, 2024
    Role: Principal Investigator
    PGRN Administrative Coordination Hub, ACH (PGRN)
    NIH/NIGMS U24GM115370Jul 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Role of ABCG2 in the disposition and anti-hyperuricemic effects of allopurinol
    NIH R01DK103729Sep 20, 2014 - Jul 31, 2018
    Role: Principal Investigator
    UCSF-Stanford Center of Excellence in Regulatory Science and Innovation
    NIH U01FD004979Apr 15, 2014 - Mar 31, 2017
    Role: Principal Investigator
    Center for Structure of Membrane Proteins
    NIH U54GM094625Sep 30, 2010 - Jun 30, 2016
    Role: Co-Investigator
    A Comprehensive Platform for Transporter Mediated Drug-Drug Interaction Studies
    NIH R44GM086970Feb 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Pharmacogenomics of Membrane Transporters
    NIH U19GM061390Apr 1, 2000 - Jun 30, 2015
    Role: Principal Investigator
    Pharmacogenetics of Membrane Transporters
    NIH U01GM061390Apr 1, 2000 - Jul 14, 2010
    Role: Principal Investigator
    NIH R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Principal Investigator
    NIH F06TW001776Jan 1, 1992
    Role: Principal Investigator
    NIH R01GM042230Jan 1, 1991 - Dec 31, 2003
    Role: Principal Investigator
    Cellular Mechanisms of Drug Elimination
    NIH R01GM036780Apr 4, 1986 - May 31, 2012
    Role: Principal Investigator
    NIH R01GM031254Mar 1, 1983 - Jun 30, 1989
    Role: Principal Investigator
    NIH P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Report of the 2023-24 AACP Research and Graduate Affairs Committee. Am J Pharm Educ. 2024 Jun 27; 100745. Patterson ME, Ellingrod VL, Feola DJ, Kunda NK, Mei KC, Oestreich JH, Farrell DF, Giacomini KM. PMID: 38944279.
      View in: PubMed   Mentions:    Fields:    
    2. Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nat Commun. 2024 May 23; 15(1):4380. Yee SW, Ferrández-Peral L, Alentorn-Moron P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Wolfreys FD, Yang J, Gestwicki JE, Capra JA, Artursson P, Newman JW, Marquès-Bonet T, Giacomini KM. PMID: 38782905.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants. Am J Hum Genet. 2024 Jun 06; 111(6):1222-1238. Silva DB, Trinidad M, Ljungdahl A, Revalde JL, Berguig GY, Wallace W, Patrick CS, Bomba L, Arkin M, Dong S, Estrada K, Hutchinson K, LeBowitz JH, Schlessinger A, Johannesen KM, Møller RS, Giacomini KM, Froelich S, Sanders SJ, Wuster A. PMID: 38781976; PMCID: PMC11179425.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters. Pharmaceutics. 2024 May 10; 16(5). Kulkarni CP, Yang J, Koleske ML, Lara G, Alam K, Raw A, Rege B, Zhao L, Lu D, Zhang L, Yu LX, Lionberger RA, Giacomini KM, Kroetz DL, Yee SW. PMID: 38794309; PMCID: PMC11124870.
      View in: PubMed   Mentions:
    5. The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics. Mol Cell. 2024 May 16; 84(10):1932-1947.e10. Yee SW, Macdonald CB, Mitrovic D, Zhou X, Koleske ML, Yang J, Buitrago Silva D, Rockefeller Grimes P, Trinidad DD, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. PMID: 38703769.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature. 2024 May; 629(8012):704-709. Cater RJ, Mukherjee D, Gil-Iturbe E, Erramilli SK, Chen T, Koo K, Santander N, Reckers A, Kloss B, Gawda T, Choy BC, Zhang Z, Katewa A, Larpthaveesarp A, Huang EJ, Mooney SWJ, Clarke OB, Yee SW, Giacomini KM, Kossiakoff AA, Quick M, Arnold T, Mancia F. PMID: 38693257; PMCID: PMC11168207.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes. Diabetes Care. 2024 Feb 01; 47(2):208-215. Wu B, Yee SW, Xiao S, Xu F, Sridhar SB, Yang M, Hochstadt S, Cabral W, Lanfear DE, Hedderson MM, Giacomini KM, Williams LK. PMID: 37639712; PMCID: PMC10834390.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Progress in Clinical Pharmacology in China: A Randomized Controlled Study to Advance Genotype-Guided Precision Medicine. Clin Pharmacol Ther. 2024 02; 115(2):169-172. Zhao L, Giacomini KM, van der Graaf PH. PMID: 38252417.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Membrane transporters in drug development and as determinants of precision medicine. Nat Rev Drug Discov. 2024 Apr; 23(4):255-280. Galetin A, Brouwer KLR, Tweedie D, Yoshida K, Sjöstedt N, Aleksunes L, Chu X, Evers R, Hafey MJ, Lai Y, Matsson P, Riselli A, Shen H, Sparreboom A, Varma MVS, Yang J, Yang X, Yee SW, Zamek-Gliszczynski MJ, Zhang L, Giacomini KM. PMID: 38267543.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Artificial intelligence, ChatGPT, and other large language models for social determinants of health: Current state and future directions. Cell Rep Med. 2024 01 16; 5(1):101356. Ong JCL, Seng BJJ, Law JZF, Low LL, Kwa ALH, Giacomini KM, Ting DSW. PMID: 38232690; PMCID: PMC10829781.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    11. Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling. CPT Pharmacometrics Syst Pharmacol. 2024 04; 13(4):576-588. Hunt JP, Dubinsky S, McKnite AM, Cheung KWK, van Groen BD, Giacomini KM, de Wildt SN, Edginton AN, Watt KM. PMID: 38156758; PMCID: PMC11015082.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Ensuring Transparency and Quality of Clinical Trial Reporting in Clinical Pharmacology & Therapeutics: Prospective Trial Registration and Compliance with Reporting Guidelines Are Required for all Clinical Trials. Clin Pharmacol Ther. 2023 12; 114(6):1153-1157. Smith DM, Minichmayr IK, Standing JF, Giacomini KM, van der Graaf PH, Peck RW. PMID: 37971383.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates. Res Sq. 2023 Sep 14. Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. PMID: 37790518; PMCID: PMC10543398.
      View in: PubMed   Mentions:
    14. TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters. Clin Pharmacol Ther. 2023 12; 114(6):1293-1303. Michel ME, Wen CC, Yee SW, Giacomini KM, Hamdoun A, Nicklisch SCT. PMID: 37657924.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    15. Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates. bioRxiv. 2023 Aug 12. Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. PMID: 37609337; PMCID: PMC10441401.
      View in: PubMed   Mentions:
    16. Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP). Diabetes. 2023 08 01; 72(8):1161-1172. Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC, Diabetes Prevention Program Research Group:. PMID: 36525397; PMCID: PMC10382652.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse. Metabolites. 2023 Jul 26; 13(8). Wen A, Zhu Y, Yee SW, Park BI, Giacomini KM, Greenberg AS, Newman JW. PMID: 37623829; PMCID: PMC10456376.
      View in: PubMed   Mentions:
    18. Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools. Nat Chem Biol. 2024 Jan; 20(1):62-73. Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R. PMID: 37474759; PMCID: PMC10746541.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Trends in Clinical Pharmacology and Therapeutics. Clin Pharmacol Ther. 2023 07; 114(1):11-14. Minichmayr IK, Smith DM, Giacomini KM, van der Graaf PH. PMID: 37335056.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics. bioRxiv. 2023 Jun 07. Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. PMID: 37333090; PMCID: PMC10274788.
      View in: PubMed   Mentions:
    21. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther. 2023 08; 114(2):381-392. Vora B, Wen A, Yee SW, Trinh K, Azimi M, Green EAE, Sirota M, Greenberg AS, Newman JW, Giacomini KM. PMID: 37151050.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    22. Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes. Pediatr Diabetes. 2023; 2023. Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson ER, Yee SW, Giacomini KM, Pollin T, Florez JC. PMID: 38590442; PMCID: PMC11000826.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat. J Vet Pharmacol Ther. 2023 Nov; 46(6):401-412. Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM. PMID: 37198956.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Biomarkers Come of Age in Clinical Pharmacology. Clin Pharmacol Ther. 2023 05; 113(5):945-947. Giacomini KM. PMID: 37069736.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All. Clin Pharmacol Ther. 2023 03; 113(3):457-461. Venkatakrishnan K, Brown KE, Giacomini KM, van der Graaf PH. PMID: 36798016.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency. Proc Natl Acad Sci U S A. 2022 Nov 16; 119(46):e2210247119. Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM. PMID: 36343260; PMCID: PMC9674959.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. More Than Pharmacokinetics: Transporters in Clinical Pharmacology. Clin Pharmacol Ther. 2022 09; 112(3):423-426. Giacomini KM, Huang SM. PMID: 35989454.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium. Clin Pharmacol Ther. 2022 09; 112(3):540-561. Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X. PMID: 35488474; PMCID: PMC9398938.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    29. A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption. AAPS J. 2022 05 02; 24(3):60. Martinez MN, Sinko B, Wu F, Flanagan T, Borbás E, Tsakalozou E, Giacomini KM. PMID: 35501614.
      View in: PubMed   Mentions: 2     Fields:    
    30. Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682. Diabetes Care. 2022 04 01; 45(4):e82-e83. Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium. PMID: 35349657; PMCID: PMC9016729.
      View in: PubMed   Mentions:    Fields:    
    31. The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms. Clin Pharmacol Ther. 2022 05; 111(5):1007-1021. Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A, Giacomini KM, Caudle KE, Voora D. PMID: 35152405; PMCID: PMC9035072.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    32. The Pandemic as a Catalyst for Disruptive Innovation in Clinical Pharmacology. Clin Pharmacol Ther. 2022 03; 111(3):529-532. Giacomini KM, van der Graaf PH. PMID: 35134255.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    33. High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3. Pharm Res. 2022 Jul; 39(7):1599-1613. Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM. PMID: 35089508; PMCID: PMC9246766.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Emerging Roles of the Human Solute Carrier 22 Family. Drug Metab Dispos. 2021 Dec 17. Yee SW, Giacomini KM. PMID: 34921098; PMCID: PMC9488978.
      View in: PubMed   Mentions: 16     Fields:    
    35. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care. 2021 12; 44(12):2673-2682. Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium, MetGen Plus investigators:. PMID: 34607834; PMCID: PMC8669535.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    36. Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein. AAPS J. 2021 09 15; 23(5):106. Bajaj R, Chong LB, Zou L, Tsakalozou E, Ni Z, Giacomini KM, Kroetz DL. PMID: 34528148; PMCID: PMC9148196.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network. Clin Pharmacol Ther. 2021 09; 110(3):559-562. Giacomini KM, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M. PMID: 34318925; PMCID: PMC8881968.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data. Clin Pharmacol Ther. 2021 07; 110(1):108-122. Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM. PMID: 33759449; PMCID: PMC8217266.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics. Clin Transl Sci. 2021 07; 14(4):1431-1443. Vora B, Brackman DJ, Zou L, Garcia-Cremades M, Sirota M, Savic RM, Giacomini KM. PMID: 33931953; PMCID: PMC8301548.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    40. Opportunities and challenges for the computational interpretation of rare variation in clinically important genes. Am J Hum Genet. 2021 04 01; 108(4):535-548. McInnes G, Sharo AG, Koleske ML, Brown JEH, Norstad M, Adhikari AN, Wang S, Brenner SE, Halpern J, Koenig BA, Magnus DC, Gallagher RC, Giacomini KM, Altman RB. PMID: 33798442; PMCID: PMC8059338.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    41. The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2. AAPS J. 2021 03 01; 23(2):35. Enogieru OJ, Koleske ML, Vora B, Ngo H, Yee SW, Chatad D, Sirota M, Giacomini KM. PMID: 33649974; PMCID: PMC7921063.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    42. A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring. Clin Pharmacol Ther. 2021 05; 109(5):1197-1202. Lavertu A, Vora B, Giacomini KM, Altman R, Rensi S. PMID: 33492663; PMCID: PMC8058244.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    43. Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins. Br J Pharmacol. 2021 03; 178(6):1459-1474. Neul C, Hofmann U, Schaeffeler E, Winter S, Klein K, Giacomini KM, Eichelbaum M, Schwab M, Nies AT. PMID: 33434947.
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    317. Cimetidine elimination from the cerebrospinal fluid of the rat. Pharm Res. 1988 Oct; 5(10):628-33. Whittico MT, Giacomini KM. PMID: 3244614.
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    318. Renal transport of drugs: an overview of methodology with application to cimetidine. Pharm Res. 1988 Aug; 5(8):465-71. Giacomini KM, Hsyu PH, Gisclon LG. PMID: 3072557.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    319. The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles. Drug Metab Dispos. 1988 May-Jun; 16(3):503-5. Hsyu PH, Wong FM, Giacomini KM. PMID: 2900748.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    320. Stereoselective binding of disopyramide to plasma proteins. Pharm Res. 1988 May; 5(5):316-8. Valdivieso L, Giacomini KM, Nelson WL, Pershe R, Blaschke TF. PMID: 3244643.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    321. Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney. Drug Metab Dispos. 1988 Mar-Apr; 16(2):331-2. Gisclon LG, Giacomini KM. PMID: 2898357.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    322. Interactions of organic anions with the organic cation transporter in renal BBMV. Am J Physiol. 1988 Jan; 254(1 Pt 2):F56-61. Hsyu PH, Gisclon LG, Hui AC, Giacomini KM. PMID: 2962517.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    323. Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium. J Pharmacol Exp Ther. 1987 Oct; 243(1):118-25. Boyd RA, Giacomini JC, Wong FM, Nelson WL, Giacomini KM. PMID: 2822893.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    324. Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney. Am J Physiol. 1987 Jul; 253(1 Pt 2):F141-50. Gisclon L, Wong FM, Giacomini KM. PMID: 3605344.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    325. Essential tyrosine residues in transport of organic cations in renal BBMV. Am J Physiol. 1987 Jun; 252(6 Pt 2):F1065-72. Hsyu PH, Giacomini KM. PMID: 2954470.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    326. The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange. J Biol Chem. 1987 Mar 25; 262(9):3964-8. Hsyu PH, Giacomini KM. PMID: 2951380.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    327. Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil. J Med Chem. 1986 Sep; 29(9):1789-92. Theodore LJ, Nelson WL, Zobrist RH, Giacomini KM, Giacomini JC. PMID: 2427721.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    328. The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site. J Mol Cell Cardiol. 1986 Sep; 18(9):963-74. Zobrist RH, Giacomini KM, Nelson WL, Giacomini JC. PMID: 3783730.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    329. In vivo interaction of the enantiomers of disopyramide in human subjects. J Pharmacokinet Biopharm. 1986 Aug; 14(4):335-56. Giacomini KM, Nelson WL, Pershe RA, Valdivieso L, Turner-Tamiyasu K, Blaschke TF. PMID: 3772736.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    330. Posttraumatic complications and inflammatory mediators. Arch Surg. 1986 Aug; 121(8):886-90. Nuytinck JK, Goris JA, Redl H, Schlag G, van Munster PJ. PMID: 3488050.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    331. High performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. I: Studies with pindolol. J Pharm Sci. 1986 Jun; 75(6):601-5. Hsyu PH, Giacomini KM. PMID: 2874209.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    332. Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel. Biochem Pharmacol. 1986 Feb 15; 35(4):716-8. Giacomini JC, Nelson WL, Wong FM, Boyd R, Zobrist RH, Giacomini KM. PMID: 2868731.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    333. Stereoselective renal clearance of pindolol in humans. J Clin Invest. 1985 Nov; 76(5):1720-6. Hsyu PH, Giacomini KM. PMID: 4056049; PMCID: PMC424192.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    334. Electrophysiology of the enantiomers of disopyramide in dogs. J Cardiovasc Pharmacol. 1985 Sep-Oct; 7(5):884-90. Giacomini JC, Giacomini KM, Nelson WL, Harrison DC, Blaschke TF. PMID: 2413296.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    335. The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits. J Cardiovasc Pharmacol. 1985 May-Jun; 7(3):469-75. Giacomini JC, Nelson WL, Theodore L, Wong FM, Rood D, Giacomini KM. PMID: 2410676.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    336. Verapamil interacts stereoselectively with the muscarinic receptor. Pharm Res. 1985 Mar; 2(2):94-5. Giacomini JC, Zobrist RH, Dave B, Giacomini KM. PMID: 24272619.
      View in: PubMed   Mentions:    Fields:    
    337. Decreased binding of verapamil to plasma proteins in patients with liver disease. J Cardiovasc Pharmacol. 1984 Sep-Oct; 6(5):924-8. Giacomini KM, Massoud N, Wong FM, Giacomini JC. PMID: 6209501.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    338. Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration. Pharm Res. 1984 Jul; 1(4):179-81. Giacomini KM, Wong FM, Tozer TN. PMID: 24277288.
      View in: PubMed   Mentions: 5     Fields:    
    339. High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma. J Chromatogr. 1984 May 11; 307(2):410-5. Smith GA, Giacomini KM, Smith CT, Gregory PB, Robinson WS, Merigan TC, Blaschke TF. PMID: 6203924.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    340. Effect of concentration-dependent binding to plasma proteins on the pharmacokinetics and pharmacodynamics of disopyramide. Clin Pharmacokinet. 1984 Jan; 9 Suppl 1:42-8. Giacomini KM, Blaschke TF. PMID: 6705426.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    341. Amitriptyline disposition in young and elderly normal men. Clin Pharmacol Ther. 1983 Mar; 33(3):360-6. Schulz P, Turner-Tamiyasu K, Smith G, Giacomini KM, Blaschke TF. PMID: 6825390.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    342. Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man. Eur J Clin Pharmacol. 1983; 25(2):211-4. Schulz P, Giacomini KM, Luttrell S, Turner-Tamiyasu K, Blaschke TF. PMID: 6628503.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    343. Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin. Ther Drug Monit. 1983; 5(4):497-9. Schulz P, Abang A, Giacomini JC, Blaschke TF, Giacomini KM. PMID: 6659020.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    344. Calculation of drug concentration in plasma after equilibrium dialysis. Br J Clin Pharmacol. 1982 Nov; 14(5):752-4. Giacomini KM, Abang A, Blaschke TF. PMID: 7138760; PMCID: PMC1427475.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    345. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study. Circulation. 1982 Aug; 66(2):447-53. Pollick C, Giacomini KM, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, Popp RL. PMID: 7094252.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    346. High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood. J Pharm Sci. 1982 May; 71(5):581-3. Smith GA, Schulz P, Giacomini KM, Blaschke TF. PMID: 7097507.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    347. Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography. J Chromatogr. 1982 Feb 12; 227(2):510-5. Swezey SF, Giacomini KM, Abang A, Brass C, Stevens DA, Blaschke TF. PMID: 6277970.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    348. The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide. J Pharmacokinet Biopharm. 1982 Feb; 10(1):1-14. Giacomini KM, Swezey SE, Turner-Tamiyasu K, Blaschke TF. PMID: 7069575.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    349. Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide. J Med Chem. 1981 May; 24(5):614-7. Nelson WL, Sneed CK, Giacomini KM, Giacomini JC, Stauss J, Blaschke TF, Cox BM. PMID: 7241519.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    350. Evaluation of methods for producing renal dysfunction in rats. J Pharm Sci. 1981 Feb; 70(2):117-21. Giacomini KM, Roberts SM, Levy G. PMID: 7205211.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    351. Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins. Biochem Pharmacol. 1980 Dec; 29(24):3337-40. Giacomini KM, Giacomini JC, Blaschke TF. PMID: 7213407.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    352. The stereoselective disposition of disopyramide in the dog. J Cardiovasc Pharmacol. 1980 Nov-Dec; 2(6):825-32. Giacomini KM, Giacomini JC, Swezey SE, Harrison DC, Nelson WL, Burke TR, Blaschke TF. PMID: 6160331.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    353. Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum. Life Sci. 1980 Sep 29; 27(13):1191-7. Giacomini KM, Cox BM, Blaschke TF. PMID: 7421405.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    354. Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt. Clin Pharmacol Ther. 1980 Sep; 28(3):417-24. Giacomini KM, Giacomini JC, Gibson TP, Levy G. PMID: 7408401.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    355. Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma. Life Sci. 1980 Sep 01; 27(9):771-80. Giacomini KM, Swezey SE, Giacomini JC, Blaschke TF. PMID: 7412503.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    356. Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs. J Pharm Sci. 1980 Jul; 69(7):786-9. Giacomini KM, Nakeeb SM, Levy G. PMID: 7391940.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    357. Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient. Clin Pharmacol Ther. 1980 May; 27(5):665-70. Gibson TP, Giacomini KM, Briggs WA, Whitman W, Levy G. PMID: 7371364.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    358. Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients. Clin Pharmacol Ther. 1980 Apr; 27(4):508-14. Giacomini KM, Gibson TP, Levy G. PMID: 7357810.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    359. Phenylalanine metabolism in uremic and normal man. Kidney Int. 1978 Aug; 14(2):169-79. Jones MR, Kopple JD, Swendseid ME. PMID: 357810.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    360. Rational aspirin dosage regimens. Clin Pharmacol Ther. 1978 Mar; 23(3):247-52. Levy G, Giacomini KM. PMID: 627128.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    361. Plasma protein binding of d-propoxyphene in normal subjects and anephric patients. J Clin Pharmacol. 1978 Feb-Mar; 18(2-3):106-9. Giacomini KM, Gibson TP, Levy G. PMID: 624774.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    362. A Convenient Method for Repetitive Blood Sampling in the Dog. J. Pharmacol. Meth. 1978; (1):259-261. Soles C, Giacomini KM, Roberts SM, Giacomini JC. Soles C, Giacomini KM, Roberts SM, Giacomini JC.
    363. [Diagnosis of toxoplasmosis by indirect hemagglutination. II. Value of mixed total antigen fixation in the presence of glutaraldehyde in the early diagnosis of the disease]. Biomedicine. 1976 Jul; 25(6):212-4. Senet JM, Robert R, Mauras G. PMID: 822893.
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