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Farzana Perwad, MD

Title(s)Associate Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
Phone415-476-2423
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    My research focus is to understand the molecular mechanisms of regulation of phosphorus and vitamin D metabolism in the setting of chronic kidney disease.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Burosumab in X-linked hypophosphatemia and perspective for chronic kidney disease. Curr Opin Nephrol Hypertens. 2020 Sep; 29(5):531-536. Balani S, Perwad F. PMID: 32701599.
      View in: PubMed   Mentions:    Fields:    
    2. Association Between Chronic Kidney Disease-Mineral Bone Disease (CKD-MBD) and Cognition in Children: Chronic Kidney Disease in Children (CKiD) Study. Kidney Med. 2020 Jul-Aug; 2(4):398-406. Yokoyama JS, Matsuda-Abedini M, Denburg MR, Kumar J, Warady BA, Furth SL, Hooper SR, Portale AA, Perwad F. PMID: 32775979.
      View in: PubMed   Mentions:
    3. OR29-01 Long-Term Safety in Adults with X-Linked Hypophosphatemia (XLH) Treated with Burosumab, a Fully Human Monoclonal Antibody Against FGF23: Final Results of a Phase 3 Trial. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1). Farzana Perwad, Anthony A Portale, Thomas O Carpenter, Karine Briot, Erik Allen Imel, Peter Kamenicky, Thomas Joseph Weber, Pisit Pitukcheewanont, Hae Il Cheong, Suzanne Marie Jan De Beur, Yasuo Imanishi, Nobuaki Ito, Robin Lachmann, Hiroyuki Tanaka, Lin Zhang, Alison Skrinar, Linda Rees, Karl Leonard Insogna. .
      View in: Publisher Site   Mentions:
    4. Association Between Chronic Kidney Disease–Mineral Bone Disease (CKD-MBD) and Cognition in Children: Chronic Kidney Disease in Children (CKiD) Study. Kidney Medicine. 2020 May 1. Jennifer S. Yokoyama, Mina Matsuda-Abedini, Michelle R. Denburg, Juhi Kumar, Bradley A. Warady, Susan L. Furth, Stephen R. Hooper, Anthony A. Portale, Farzana Perwad. .
      View in: Publisher Site   Mentions:
    5. a-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases. Pediatrics. 2020 05; 145(5). Cil O, Perwad F. PMID: 32245805.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial. . 2019 Sep 12. Imel EA, Glorieux FH, Whyte MP, Munns CF, Ward LM, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Hogler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Mao M, Chen CY, Skrinar A, San Martin J, Portale AA. .
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    7. Fibroblast growth factor 23 and phosphate homeostasis. Curr Opin Nephrol Hypertens. 2019 09; 28(5):465-473. Balani S, Perwad F. PMID: 31335449.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. Risk Factors for Transplant-Associated Thrombotic Microangiopathy after Autologous Hematopoietic Cell Transplant in High-Risk Neuroblastoma. Biol Blood Marrow Transplant. 2019 10; 25(10):2031-2039. Tolbert VP, Dvorak CC, Golden C, Vissa M, El-Haj N, Perwad F, Matthay KK, Vo KT. PMID: 31199983.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Burosumab Therapy for X-Linked Hypophosphatemia and Therapeutic Implications for CKD. Clin J Am Soc Nephrol. 2019 07 05; 14(7):1097-1099. Perwad F, Portale AA. PMID: 31171590.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. Continued Beneficial Effects of Burosumab in Adults with X-Linked Hypophosphatemia: Results from a 24-Week Treatment Continuation Period After a 24-Week Double-Blind Placebo-Controlled Period. Calcif Tissue Int. 2019 Sep; 105(3):271-284. Portale AA, Carpenter TO, Brandi ML, Briot K, Cheong HI, Cohen-Solal M, Crowley R, Jan De Beur S, Eastell R, Imanishi Y, Imel EA, Ing S, Ito N, Javaid M, Kamenicky P, Keen R, Kubota T, Lachmann R, Perwad F, Pitukcheewanont P, Ralston SH, Takeuchi Y, Tanaka H, Weber TJ, Yoo HW, Zhang L, Theodore-Oklota C, Mealiffe M, San Martin J, Insogna K. PMID: 31165191.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    11. Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial. Lancet. 2019 06 15; 393(10189):2416-2427. Imel EA, Glorieux FH, Whyte MP, Munns CF, Ward LM, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Mao M, Chen CY, Skrinar A, San Martin J, Portale AA. PMID: 31104833.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    12. Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation. Kidney Int. 2019 10; 96(4):890-905. Egli-Spichtig D, Imenez Silva PH, Glaudemans B, Gehring N, Bettoni C, Zhang MYH, Pastor-Arroyo EM, Schönenberger D, Rajski M, Hoogewijs D, Knauf F, Misselwitz B, Frey-Wagner I, Rogler G, Ackermann D, Ponte B, Pruijm M, Leichtle A, Fiedler GM, Bochud M, Ballotta V, Hofmann S, Perwad F, Föller M, Lang F, Wenger RH, Frew I, Wagner CA. PMID: 31301888.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies. J Clin Invest. 2018 12 03; 128(12):5368-5373. Roberts MS, Burbelo PD, Egli-Spichtig D, Perwad F, Romero CJ, Ichikawa S, Farrow E, Econs MJ, Guthrie LC, Collins MT, Gafni RI. PMID: 30226830.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Fibroblast Growth Factor 23 Expression Is Increased in Multiple Organs in Mice With Folic Acid-Induced Acute Kidney Injury. Front Physiol. 2018; 9:1494. Egli-Spichtig D, Zhang MYH, Perwad F. PMID: 30405444.
      View in: PubMed   Mentions:
    15. Vitamin D and kidney disease. Bone Rep. 2018 Dec; 9:93-100. Keung L, Perwad F. PMID: 30591927.
      View in: PubMed   Mentions:
    16. A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. J Bone Miner Res. 2018 08; 33(8):1383-1393. Insogna KL, Briot K, Imel EA, Kamenický P, Ruppe MD, Portale AA, Weber T, Pitukcheewanont P, Cheong HI, Jan de Beur S, Imanishi Y, Ito N, Lachmann RH, Tanaka H, Perwad F, Zhang L, Chen CY, Theodore-Oklota C, Mealiffe M, San Martin J, Carpenter TO. PMID: 29947083.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCTClinical Trials
    17. Monogenic Causes of Proteinuria in Children. Front Med (Lausanne). 2018; 5:55. Cil O, Perwad F. PMID: 29594119.
      View in: PubMed   Mentions:
    18. Autoimmune hyperphosphatemic tumoral calcinosis. Bone Abstracts. 2017 Jul 11. Mary Scott Ramnitz, Peter Burbelo, Daniela Egli-Spichtig, Farzana Perwad, Christopher Romero, Shoji Ichikawa, Emily Farrow, Michael Econs, Lori Guthrie, Rachel I. Gafni, Michael T. Collins. .
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    19. Fibroblast Growth Factor 23 and Risk of CKD Progression in Children. Clin J Am Soc Nephrol. 2016 11 07; 11(11):1989-1998. Portale AA, Wolf MS, Messinger S, Perwad F, Jüppner H, Warady BA, Furth SL, Salusky IB. PMID: 27561289.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    20. Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule. PLoS One. 2015; 10(11):e0142924. Portale AA, Zhang MY, David V, Martin A, Jiao Y, Gu W, Perwad F. PMID: 26588476.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. Phosphate Homeostasis and Metabolic Bone Disease. The Physiological Basis of Metabolic Bone Disease. 2014 May 27; 137-166. Farzana Perwad, Anthony Portale. .
      View in: Publisher Site   Mentions:
    22. FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues. PLoS One. 2013; 8(9):e72816. Chanakul A, Zhang MY, Louw A, Armbrecht HJ, Miller WL, Portale AA, Perwad F. PMID: 24019880.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    23. Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice. Endocrinology. 2012 Apr; 153(4):1806-16. Zhang MY, Ranch D, Pereira RC, Armbrecht HJ, Portale AA, Perwad F. PMID: 22334725.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    24. Chapter 25 Rickets Due to Hereditary Abnormalities of Vitamin D Synthesis or Action. Pediatric Bone. 2012 Jan 1; 679-698. Anthony A. Portale, Farzana Perwad, Walter L. Miller. .
      View in: Publisher Site   Mentions:
    25. Vitamin D metabolism in the kidney: regulation by phosphorus and fibroblast growth factor 23. Mol Cell Endocrinol. 2011 Dec 05; 347(1-2):17-24. Perwad F, Portale AA. PMID: 21914460.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice. J Bone Miner Res. 2011 Aug; 26(8):1883-90. Ranch D, Zhang MY, Portale AA, Perwad F. PMID: 21472778.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    27. Calcium and Phosphorus. Pediatric Nephrology. 2009 Jan 1; 231-265. Anthony A. Portale, Farzana Perwad. .
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    28. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1577-83. Perwad F, Zhang MY, Tenenhouse HS, Portale AA. PMID: 17699549.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    29. Vitamin D 1alpha-hydroxylase gene mutations in patients with 1alpha-hydroxylase deficiency. J Clin Endocrinol Metab. 2007 Aug; 92(8):3177-82. Kim CJ, Kaplan LE, Perwad F, Huang N, Sharma A, Choi Y, Miller WL, Portale AA. PMID: 17488797.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    30. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology. 2005 Dec; 146(12):5358-64. Perwad F, Azam N, Zhang MY, Yamashita T, Tenenhouse HS, Portale AA. PMID: 16123154.
      View in: PubMed   Mentions: 118     Fields:    Translation:Animals
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