Thiennu Vu, MD, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address2330 Post Street
San Francisco CA 94115
Phone415-885-7755
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1996 Medicine
    University of California, San FranciscoM.D.1991 Medicine
    University of California, San FranciscoPh.D.1990 Graduate Division (Cell Biology)

    Collapse Overview 
    Collapse Overview
    Dr. Vu received her M.D. and Ph.D. from the University of California, San Francisco in 1991 after completion of the Medical Scientist Training Program. She completed a Residency in Internal Medicine at the University of California, San Diego and a Fellowship in Pulmonary and Critical Care Medicine at UCSF. She was the principal investigator of a research program focusing on the molecular mechanisms of lung development and the biology of lung progenitor and stem cells from 2000 to 2016. She currently practices pulmonary medicine at the UCSF Mt Zion Pulmonary clinic.

    Collapse Research 
    Collapse Research Activities and Funding
    Cell type-specific influences on HHT pathogenesis
    NIH R01 HL122774Jan 16, 2015 - Dec 31, 2018
    Role: Co-Investigator
    Role of VEGF in Perinatal Pulmonary Hypertension
    NIH R01 HL068702Sep 1, 2012 - Jul 31, 2016
    Role: Collaborator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH U01 HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Co-Investigator
    Extracellular Remodeling in Bone Development and Repair
    NIH R01 AR46238Apr 15, 2006 - Mar 31, 2011
    Notch Signaling in Lung Vascularization and Development
    NIH R01HL075680Sep 30, 2003 - Aug 31, 2008
    Role: Principal Investigator
    The Regulation of Pulmonary Vascular Development
    NIH K02HL073823Aug 1, 2003 - Jul 31, 2008
    Role: Principal Investigator
    The Function of VEGF Family in Lung Vascular Development
    NIH R01HL069925Apr 1, 2002 - Mar 31, 2007
    Role: Principal Investigator
    EPITHELIAL MESENCHYMAL INTERACTIONS IN LUNG DEVELOPMENT
    NIH K08HL003880Aug 1, 1998 - Jul 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity. Stroke. 2017 05; 48(5):1420-1423. Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H. PMID: 28325846; PMCID: PMC5404983.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    2. VEGF and endothelium-derived retinoic acid regulate lung vascular and alveolar development. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15; 310(4):L287-98. Yun EJ, Lorizio W, Seedorf G, Abman SH, Vu TH. PMID: 26566904; PMCID: PMC4754906.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    3. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 07; 15(2):123-38. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. PMID: 25105578; PMCID: PMC4212493.
      View in: PubMed   Mentions: 340     Fields:    Translation:HumansAnimalsCells
    4. mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development. Anat Rec (Hoboken). 2012 Jan; 295(1):167-76. Yun EJ, Vu TH. PMID: 21956870.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    5. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. Journal of Clinical Investigation. 2011 Aug 1; 121(8):3360-3360. Chapman CH, Li LX, Alexander AJ, Brumwell BA, Lorizio LW, Tan TK, Sonnenberg SA, Wei WY, Vu VT. .
      View in: Publisher Site   Mentions:
    6. Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011 Jul; 121(7):2855-62. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. PMID: 21701069; PMCID: PMC3223845.
      View in: PubMed   Mentions: 212     Fields:    Translation:AnimalsCells
    7. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Dis Model Mech. 2010 Mar-Apr; 3(3-4):224-35. Ortega N, Wang K, Ferrara N, Werb Z, Vu TH. PMID: 20142327; PMCID: PMC2869494.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    8. Ablation of lung epithelial cells deregulates FGF-10 expression and impairs lung branching morphogenesis. Anat Rec (Hoboken). 2009 Jan; 292(1):123-30. Kim N, Yamamoto H, Pauling MH, Lorizio W, Vu TH. PMID: 19115389; PMCID: PMC2913580.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    9. P311 functions in an alternative pathway of lipid accumulation that is induced by retinoic acid. J Cell Sci. 2008 Aug 15; 121(Pt 16):2751-8. Leung JK, Cases S, Vu TH. PMID: 18664493; PMCID: PMC2975553.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007 Aug 01; 308(1):44-53. Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA, Vu TH. PMID: 17583691.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    11. Parabronchial smooth muscle cells and alveolar myofibroblasts in lung development. Birth Defects Res C Embryo Today. 2006 Mar; 78(1):80-9. Kim N, Vu TH. PMID: 16622850.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    12. Identification of P311 as a potential gene regulating alveolar generation. Am J Respir Cell Mol Biol. 2006 Jul; 35(1):48-54. Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH. PMID: 16484684; PMCID: PMC2658697.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    13. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. J Invest Dermatol. 2006 Feb; 126(2):486-96. Hartenstein B, Dittrich BT, Stickens D, Heyer B, Vu TH, Teurich S, Schorpp-Kistner M, Werb Z, Angel P. PMID: 16374453; PMCID: PMC2767339.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    14. Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech Dev. 2005 Jul; 122(7-8):877-86. Zhao L, Wang K, Ferrara N, Vu TH. PMID: 15927453.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    15. Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem. 2004 Dec 17; 279(51):53848-56. Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH. PMID: 15456762; PMCID: PMC2779713.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    16. Mechanisms and regulation of lung vascular development. Curr Top Dev Biol. 2004; 64:73-99. Pauling MH, Vu TH. PMID: 15563945.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. New insights into saccular development and vascular formation in lung allografts under the renal capsule. Mech Dev. 2003 Mar; 120(3):305-13. Vu TH, Alemayehu Y, Werb Z. PMID: 12591600; PMCID: PMC2774927.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Don't mess with the matrix. Nat Genet. 2001 Jul; 28(3):202-3. Vu TH. PMID: 11431682.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    19. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol. 2000 Nov 13; 151(4):879-89. Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, Henriksen K, Lenhard T, Foged NT, Werb Z, Delaissé JM. PMID: 11076971; PMCID: PMC2169432.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    20. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol. 2000 Oct; 2(10):737-44. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D. PMID: 11025665; PMCID: PMC2852586.
      View in: PubMed   Mentions: 887     Fields:    Translation:AnimalsCells
    21. Biology and Regulation of the Matrix Metalloproteinases. Matrix Metalloproteinase Inhibitors in Cancer Therapy. 2000 Sep 17; 0:1-37. Sternlicht SM, Coussens CL, Vu VT, Werb WZ. .
      View in: Publisher Site   Mentions:
    22. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 2000 Sep 01; 14(17):2123-33. Vu TH, Werb Z. PMID: 10970876.
      View in: PubMed   Mentions: 327     Fields:    Translation:HumansAnimalsCells
    23. Proteinases in bone resorption: obvious and less obvious roles. Clin Chim Acta. 2000 Feb 15; 291(2):223-34. Delaissé JM, Engsig MT, Everts V, del Carmen Ovejero M, Ferreras M, Lund L, Vu TH, Werb Z, Winding B, Lochter A, Karsdal MA, Troen T, Kirkegaard T, Lenhard T, Heegaard AM, Neff L, Baron R, Foged NT. PMID: 10675725.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    24. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med. 1999 Jun; 5(6):623-8. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. PMID: 10371499.
      View in: PubMed   Mentions: 528     Fields:    Translation:AnimalsCells
    25. Matrix-degrading proteases and angiogenesis during development and tumor formation. APMIS. 1999 Jan; 107(1):11-8. Werb Z, Vu TH, Rinkenberger JL, Coussens LM. PMID: 10190275.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    26. Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid. J Exp Med. 1998 Aug 03; 188(3):475-82. Liu Z, Shipley JM, Vu TH, Zhou X, Diaz LA, Werb Z, Senior RM. PMID: 9687525; PMCID: PMC2212482.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    27. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 1998 May 01; 93(3):411-22. Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z. PMID: 9590175; PMCID: PMC2839071.
      View in: PubMed   Mentions: 495     Fields:    Translation:AnimalsCells
    28. Gelatinase B: Structure, Regulation, and Function. Matrix Metalloproteinases. 1998 Jan 1; 115-148. Vu VT, Werb WZ. .
      View in: Publisher Site   Mentions:
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