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Thiennu Vu, MD, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-514-4266
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1996 Medicine
    University of California, San FranciscoM.D.1991 Medicine
    University of California, San FranciscoPh.D.1990 Graduate Division (Cell Biology)

    Collapse Overview 
    Collapse Overview
    Dr. Vu received her M.D. and Ph.D. from the University of California, San Francisco in 1991 after completion of the Medical Scientist Training Program. She completed a Residency in Internal Medicine at the University of California, San Diego and a Fellowship in Pulmonary and Critical Care Medicine at UCSF. Besides engaging in basic research, she also practices clinical medicine, serving as attending physician in the San Francisco Department of Public Health Tuberculosis control clinic and in the UCSF Parnassus Chest clinic.

    Research Interests:

    1) The role of the vasculature in organogenesis: We are interested in the molecular mechanisms of tissue vascularization and the role of the vasculature in tissue formation. Our hypothesis is that there are reciprocal inductive interactions between the tissue and its vasculature during organogenesis. This is strongly suggested in the lungs by the intimate relationship between airways and lung blood vessels, which is critical for normal lung function. Our goals are to identify the molecular and cellular mechanisms that mediate the cross talk between epithelium and mesenchyme to coordinate airway and vessel development during lung formation.

    2) The development of pulmonary alveoli: Another area of interest of the lab is the development of the distal lung, namely, the formation of alveoli. These are key functional units of the lungs where gas exchange takes place, yet the regulation of alveolar morphogenesis is not well understood. Our hypothesis is that since the formation of alveoli occurs in a defined period, genes that regulate alveolar morphogenesis must be differentially expressed during periods of active and inactive alveolar formation. We are attempting to identify genes that regulate alveolar development by isolating genes differentially expressed between these stages. The role of candidate genes will then be tested using gain- and loss-of function studies both in vitro and in vivo.

    3) The development and function of lung myofibroblasts: Lung myofibroblasts are interstitial smooth muscle-like cells that are essential for alveolar development. They are also implicated in the pathogenesis of many lung diseases including pulmonary fibrosis. The regulation of myofibroblast development and function is not well understood. We are interested in identifying the molecular and cellular mechanisms that regulate myofibroblasts in development and in disease.

    4) The biology of lung progenitor and stem cells: As a rule the adult lungs do not regenerate and the response to lung injury in many cases is fibrosis. We are interested in identifying whether there are populations of progenitor or stem cells in the adult lungs that can be stimulated to repair and regenerate damaged lungs. We are also interested in identifying conditions that support the growth and differentiation of resident lung progenitor and stem cells or that induce bone marrow derived stem cells to populate and regenerate lung tissues.

    Collapse Research 
    Collapse Research Activities and Funding
    Notch Signaling in Lung Vascularization and Development
    NIH/NHLBI R01HL075680Sep 30, 2003 - Aug 31, 2008
    Role: Principal Investigator
    The Regulation of Pulmonary Vascular Development
    NIH/NHLBI K02HL073823Aug 1, 2003 - Jul 31, 2008
    Role: Principal Investigator
    The Function of VEGF Family in Lung Vascular Development
    NIH/NHLBI R01HL069925Apr 1, 2002 - Mar 31, 2007
    Role: Principal Investigator
    EPITHELIAL MESENCHYMAL INTERACTIONS IN LUNG DEVELOPMENT
    NIH/NHLBI K08HL003880Aug 1, 1998 - Jul 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity. Stroke. 2017 05; 48(5):1420-1423. Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H. PMID: 28325846.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    2. VEGF and endothelium-derived retinoic acid regulate lung vascular and alveolar development. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15; 310(4):L287-98. Yun EJ, Lorizio W, Seedorf G, Abman SH, Vu TH. PMID: 26566904.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    3. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 07; 15(2):123-38. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. PMID: 25105578.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    4. mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development. Anat Rec (Hoboken). 2012 Jan; 295(1):167-76. Yun EJ, Vu TH. PMID: 21956870.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. Journal of Clinical Investigation. 2011 Aug 1; 121(8):3360-3360. Harold A. Chapman, Xiaopeng Li, Jonathan P. Alexander, Alexis Brumwell, Walter Lorizio, Kevin Tan, Arnoud Sonnenberg, Ying Wei, Thiennu H. Vu. .
      View in: Publisher Site   Mentions:
    6. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011 Jul; 121(7):2855-62. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. PMID: 21701069.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    7. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Dis Model Mech. 2010 Mar-Apr; 3(3-4):224-35. Ortega N, Wang K, Ferrara N, Werb Z, Vu TH. PMID: 20142327.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    8. Ablation of lung epithelial cells deregulates FGF-10 expression and impairs lung branching morphogenesis. Anat Rec (Hoboken). 2009 Jan; 292(1):123-30. Kim N, Yamamoto H, Pauling MH, Lorizio W, Vu TH. PMID: 19115389.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    9. P311 functions in an alternative pathway of lipid accumulation that is induced by retinoic acid. J Cell Sci. 2008 Aug 15; 121(Pt 16):2751-8. Leung JK, Cases S, Vu TH. PMID: 18664493.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007 Aug 01; 308(1):44-53. Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA, Vu TH. PMID: 17583691.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    11. Parabronchial smooth muscle cells and alveolar myofibroblasts in lung development. Birth Defects Res C Embryo Today. 2006 Mar; 78(1):80-9. Kim N, Vu TH. PMID: 16622850.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    12. Identification of P311 as a potential gene regulating alveolar generation. Am J Respir Cell Mol Biol. 2006 Jul; 35(1):48-54. Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH. PMID: 16484684.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. J Invest Dermatol. 2006 Feb; 126(2):486-96. Hartenstein B, Dittrich BT, Stickens D, Heyer B, Vu TH, Teurich S, Schorpp-Kistner M, Werb Z, Angel P. PMID: 16374453.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    14. Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech Dev. 2005 Jul; 122(7-8):877-86. Zhao L, Wang K, Ferrara N, Vu TH. PMID: 15927453.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    15. Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem. 2004 Dec 17; 279(51):53848-56. Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH. PMID: 15456762.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    16. Mechanisms and regulation of lung vascular development. Curr Top Dev Biol. 2004; 64:73-99. Pauling MH, Vu TH. PMID: 15563945.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. New insights into saccular development and vascular formation in lung allografts under the renal capsule. Mech Dev. 2003 Mar; 120(3):305-13. Vu TH, Alemayehu Y, Werb Z. PMID: 12591600.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. Don't mess with the matrix. Nat Genet. 2001 Jul; 28(3):202-3. Vu TH. PMID: 11431682.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol. 2000 Nov 13; 151(4):879-89. Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, Henriksen K, Lenhard T, Foged NT, Werb Z, Delaissé JM. PMID: 11076971.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    20. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol. 2000 Oct; 2(10):737-44. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D. PMID: 11025665.
      View in: PubMed   Mentions: 712     Fields:    Translation:AnimalsCells
    21. Biology and Regulation of the Matrix Metalloproteinases. Matrix Metalloproteinase Inhibitors in Cancer Therapy. 2000 Sep 17; 0:1-37. Mark D. Sternlicht, Lisa M. Coussens, Thiennu H. Vu, Zena Werb. .
      View in: Publisher Site   Mentions:
    22. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 2000 Sep 01; 14(17):2123-33. Vu TH, Werb Z. PMID: 10970876.
      View in: PubMed   Mentions: 283     Fields:    Translation:HumansAnimalsCells
    23. Proteinases in bone resorption: obvious and less obvious roles. Clin Chim Acta. 2000 Feb 15; 291(2):223-34. Delaissé JM, Engsig MT, Everts V, del Carmen Ovejero M, Ferreras M, Lund L, Vu TH, Werb Z, Winding B, Lochter A, Karsdal MA, Troen T, Kirkegaard T, Lenhard T, Heegaard AM, Neff L, Baron R, Foged NT. PMID: 10675725.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    24. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med. 1999 Jun; 5(6):623-8. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. PMID: 10371499.
      View in: PubMed   Mentions: 416     Fields:    Translation:AnimalsCells
    25. Matrix-degrading proteases and angiogenesis during development and tumor formation. APMIS. 1999 Jan; 107(1):11-8. Werb Z, Vu TH, Rinkenberger JL, Coussens LM. PMID: 10190275.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    26. Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid. J Exp Med. 1998 Aug 03; 188(3):475-82. Liu Z, Shipley JM, Vu TH, Zhou X, Diaz LA, Werb Z, Senior RM. PMID: 9687525.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    27. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 1998 May 01; 93(3):411-22. Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z. PMID: 9590175.
      View in: PubMed   Mentions: 408     Fields:    Translation:AnimalsCells
    28. Gelatinase B: Structure, Regulation, and Function. Matrix Metalloproteinases. 1998 Jan 1; 115-148. Thiennu H. Vu, Zena Werb. .
      View in: Publisher Site   Mentions:
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